FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE5722, 870 aa 1>>>pF1KE5722 870 - 870 aa - 870 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 8.2209+/-0.000584; mu= 7.3117+/- 0.036 mean_var=273.2006+/-63.015, 0's: 0 Z-trim(113.3): 446 B-trim: 1035 in 2/56 Lambda= 0.077595 statistics sampled from 21927 (22520) to 21927 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.617), E-opt: 0.2 (0.264), width: 16 Scan time: 8.570 The best scores are: opt bits E(85289) NP_001355 (OMIM: 603583) disks large homolog 2 iso ( 870) 5787 663.1 1.6e-189 XP_011543084 (OMIM: 603583) PREDICTED: disks large ( 891) 5685 651.7 4.5e-186 NP_001136171 (OMIM: 603583) disks large homolog 2 ( 975) 5685 651.7 4.7e-186 XP_011543080 (OMIM: 603583) PREDICTED: disks large (1025) 5685 651.7 4.9e-186 XP_016872763 (OMIM: 603583) PREDICTED: disks large ( 866) 5543 635.7 2.7e-181 NP_001193698 (OMIM: 603583) disks large homolog 2 ( 909) 5332 612.2 3.6e-174 XP_005273867 (OMIM: 603583) PREDICTED: disks large ( 837) 5318 610.5 1e-173 XP_016872771 (OMIM: 603583) PREDICTED: disks large ( 811) 5082 584.1 8.8e-166 XP_016872756 (OMIM: 603583) PREDICTED: disks large ( 884) 4380 505.6 4.2e-142 XP_016872757 (OMIM: 603583) PREDICTED: disks large ( 883) 4362 503.6 1.7e-141 XP_016872758 (OMIM: 603583) PREDICTED: disks large ( 880) 4299 496.5 2.3e-139 XP_016872753 (OMIM: 603583) PREDICTED: disks large ( 904) 4285 494.9 6.8e-139 XP_016872754 (OMIM: 603583) PREDICTED: disks large ( 903) 4278 494.2 1.2e-138 XP_016872752 (OMIM: 603583) PREDICTED: disks large ( 905) 4278 494.2 1.2e-138 XP_016872747 (OMIM: 603583) PREDICTED: disks large ( 985) 4278 494.2 1.2e-138 XP_016872745 (OMIM: 603583) PREDICTED: disks large (1026) 4278 494.2 1.3e-138 XP_016872744 (OMIM: 603583) PREDICTED: disks large (1026) 4278 494.2 1.3e-138 XP_016872743 (OMIM: 603583) PREDICTED: disks large (1039) 4278 494.2 1.3e-138 XP_016872746 (OMIM: 603583) PREDICTED: disks large (1025) 4272 493.6 2e-138 NP_001287912 (OMIM: 603583) disks large homolog 2 ( 852) 4158 480.7 1.3e-134 XP_016872765 (OMIM: 603583) PREDICTED: disks large ( 848) 4077 471.6 6.7e-132 XP_016872760 (OMIM: 603583) PREDICTED: disks large ( 872) 4063 470.1 2e-131 XP_016872761 (OMIM: 603583) PREDICTED: disks large ( 871) 4056 469.3 3.5e-131 XP_016872759 (OMIM: 603583) PREDICTED: disks large ( 873) 4056 469.3 3.5e-131 XP_016872748 (OMIM: 603583) PREDICTED: disks large ( 969) 4056 469.3 3.7e-131 XP_011543082 (OMIM: 603583) PREDICTED: disks large (1007) 4056 469.4 3.8e-131 XP_016872749 (OMIM: 603583) PREDICTED: disks large ( 968) 4050 468.7 5.9e-131 XP_016872751 (OMIM: 603583) PREDICTED: disks large ( 923) 3925 454.7 9.4e-127 XP_016872766 (OMIM: 603583) PREDICTED: disks large ( 842) 3916 453.6 1.8e-126 XP_016872773 (OMIM: 603583) PREDICTED: disks large ( 801) 3794 439.9 2.2e-122 XP_016872755 (OMIM: 603583) PREDICTED: disks large ( 891) 3703 429.8 2.8e-119 XP_016872772 (OMIM: 603583) PREDICTED: disks large ( 810) 3694 428.7 5.2e-119 XP_005273868 (OMIM: 603583) PREDICTED: disks large ( 819) 3689 428.2 7.8e-119 XP_016872775 (OMIM: 603583) PREDICTED: disks large ( 757) 3418 397.8 1e-109 XP_016872764 (OMIM: 603583) PREDICTED: disks large ( 857) 3183 371.6 9e-102 XP_016884811 (OMIM: 300189,300850) PREDICTED: disk ( 498) 2475 292.0 4.6e-78 XP_011529185 (OMIM: 300189,300850) PREDICTED: disk ( 835) 2475 292.3 6.4e-78 XP_016884812 (OMIM: 300189,300850) PREDICTED: disk ( 494) 2341 277.0 1.5e-73 XP_006724689 (OMIM: 300189,300850) PREDICTED: disk ( 831) 2341 277.3 2.1e-73 XP_016872774 (OMIM: 603583) PREDICTED: disks large ( 796) 2182 259.5 4.6e-68 XP_016872770 (OMIM: 603583) PREDICTED: disks large ( 820) 2168 257.9 1.4e-67 XP_016872768 (OMIM: 603583) PREDICTED: disks large ( 821) 2161 257.1 2.4e-67 XP_016872750 (OMIM: 603583) PREDICTED: disks large ( 955) 2161 257.2 2.7e-67 XP_016872769 (OMIM: 603583) PREDICTED: disks large ( 820) 2155 256.4 3.9e-67 XP_016872767 (OMIM: 603583) PREDICTED: disks large ( 839) 1808 217.6 1.9e-55 XP_016872762 (OMIM: 603583) PREDICTED: disks large ( 871) 1808 217.6 2e-55 XP_011543090 (OMIM: 603583) PREDICTED: disks large ( 767) 1794 216.0 5.4e-55 NP_001136172 (OMIM: 603583) disks large homolog 2 ( 749) 1680 203.2 3.7e-51 XP_011510811 (OMIM: 601014) PREDICTED: disks large ( 554) 1606 194.8 9.5e-49 XP_011510807 (OMIM: 601014) PREDICTED: disks large ( 871) 1606 195.0 1.3e-48 >>NP_001355 (OMIM: 603583) disks large homolog 2 isoform (870 aa) initn: 5787 init1: 5787 opt: 5787 Z-score: 3523.5 bits: 663.1 E(85289): 1.6e-189 Smith-Waterman score: 5787; 100.0% identity (100.0% similar) in 870 aa overlap (1-870:1-870) 10 20 30 40 50 60 pF1KE5 MFFACYCALRTNVKKYRYQDEDAPHDHSLPRLTHEVRGPELVHVSEKNLSQIENVHGYVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MFFACYCALRTNVKKYRYQDEDAPHDHSLPRLTHEVRGPELVHVSEKNLSQIENVHGYVL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE5 QSHISPLKASPAPIIVNTDTLDTIPYVNGTEIEYEFEEITLERGNSGLGFSIAGGTDNPH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QSHISPLKASPAPIIVNTDTLDTIPYVNGTEIEYEFEEITLERGNSGLGFSIAGGTDNPH 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE5 IGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLY 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE5 VRRRRPILETVVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VRRRRPILETVVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQ 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE5 VGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKVGKPTTIYMTDPYGPPDITHSYSPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKVGKPTTIYMTDPYGPPDITHSYSPP 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE5 MENHLLSGNNGTLEYKTSLPPISPGRYSPIPKHMLVDDDYTRPPEPVYSTVNKLCDKPAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MENHLLSGNNGTLEYKTSLPPISPGRYSPIPKHMLVDDDYTRPPEPVYSTVNKLCDKPAS 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE5 PRHYSPVECDKSFLLSAPYSHYHLGLLPDSEMTSHSQHSTATRQPSMTLQRAVSLEGEPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PRHYSPVECDKSFLLSAPYSHYHLGLLPDSEMTSHSQHSTATRQPSMTLQRAVSLEGEPR 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE5 KVVLHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KVVLHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASH 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE5 EQAAAALKGAGQTVTIIAQYQPEDYARFEAKIHDLREQMMNHSMSSGSGSLRTNQKRSLY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EQAAAALKGAGQTVTIIAQYQPEDYARFEAKIHDLREQMMNHSMSSGSGSLRTNQKRSLY 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE5 VRAMFDYDKSKDSGLPSQGLSFKYGDILHVINASDDEWWQARRVMLEGDSEEMGVIPSKR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VRAMFDYDKSKDSGLPSQGLSFKYGDILHVINASDDEWWQARRVMLEGDSEEMGVIPSKR 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE5 RVERKERARLKTVKFNAKPGVIDSKGSFNDKRKKSFIFSRKFPFYKNKEQSEQETSDPER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RVERKERARLKTVKFNAKPGVIDSKGSFNDKRKKSFIFSRKFPFYKNKEQSEQETSDPER 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE5 GQEDLILSYEPVTRQEINYTRPVIILGPMKDRINDDLISEFPDKFGSCVPHTTRPKRDYE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GQEDLILSYEPVTRQEINYTRPVIILGPMKDRINDDLISEFPDKFGSCVPHTTRPKRDYE 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE5 VDGRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYGTSVQSVRFVAERGKHCILDVSGNA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VDGRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYGTSVQSVRFVAERGKHCILDVSGNA 730 740 750 760 770 780 790 800 810 820 830 840 pF1KE5 IKRLQVAQLYPIAIFIKPRSLEPLMEMNKRLTEEQAKKTYDRAIKLEQEFGEYFTAIVQG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IKRLQVAQLYPIAIFIKPRSLEPLMEMNKRLTEEQAKKTYDRAIKLEQEFGEYFTAIVQG 790 800 810 820 830 840 850 860 870 pF1KE5 DTLEDIYNQCKLVIEEQSGPFIWIPSKEKL :::::::::::::::::::::::::::::: NP_001 DTLEDIYNQCKLVIEEQSGPFIWIPSKEKL 850 860 870 >>XP_011543084 (OMIM: 603583) PREDICTED: disks large hom (891 aa) initn: 5685 init1: 5685 opt: 5685 Z-score: 3461.6 bits: 651.7 E(85289): 4.5e-186 Smith-Waterman score: 5685; 100.0% identity (100.0% similar) in 856 aa overlap (15-870:36-891) 10 20 30 40 pF1KE5 MFFACYCALRTNVKKYRYQDEDAPHDHSLPRLTHEVRGPELVHV :::::::::::::::::::::::::::::: XP_011 IVTTKQNQGRCPAQNCSVEAPAWMPVHHCTKYRYQDEDAPHDHSLPRLTHEVRGPELVHV 10 20 30 40 50 60 50 60 70 80 90 100 pF1KE5 SEKNLSQIENVHGYVLQSHISPLKASPAPIIVNTDTLDTIPYVNGTEIEYEFEEITLERG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SEKNLSQIENVHGYVLQSHISPLKASPAPIIVNTDTLDTIPYVNGTEIEYEFEEITLERG 70 80 90 100 110 120 110 120 130 140 150 160 pF1KE5 NSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHS 130 140 150 160 170 180 170 180 190 200 210 220 pF1KE5 KAVEALKEAGSIVRLYVRRRRPILETVVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KAVEALKEAGSIVRLYVRRRRPILETVVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYV 190 200 210 220 230 240 230 240 250 260 270 280 pF1KE5 TKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKVGKPTTIYM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKVGKPTTIYM 250 260 270 280 290 300 290 300 310 320 330 340 pF1KE5 TDPYGPPDITHSYSPPMENHLLSGNNGTLEYKTSLPPISPGRYSPIPKHMLVDDDYTRPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TDPYGPPDITHSYSPPMENHLLSGNNGTLEYKTSLPPISPGRYSPIPKHMLVDDDYTRPP 310 320 330 340 350 360 350 360 370 380 390 400 pF1KE5 EPVYSTVNKLCDKPASPRHYSPVECDKSFLLSAPYSHYHLGLLPDSEMTSHSQHSTATRQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EPVYSTVNKLCDKPASPRHYSPVECDKSFLLSAPYSHYHLGLLPDSEMTSHSQHSTATRQ 370 380 390 400 410 420 410 420 430 440 450 460 pF1KE5 PSMTLQRAVSLEGEPRKVVLHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PSMTLQRAVSLEGEPRKVVLHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRG 430 440 450 460 470 480 470 480 490 500 510 520 pF1KE5 DQILSVNGIDLRGASHEQAAAALKGAGQTVTIIAQYQPEDYARFEAKIHDLREQMMNHSM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DQILSVNGIDLRGASHEQAAAALKGAGQTVTIIAQYQPEDYARFEAKIHDLREQMMNHSM 490 500 510 520 530 540 530 540 550 560 570 580 pF1KE5 SSGSGSLRTNQKRSLYVRAMFDYDKSKDSGLPSQGLSFKYGDILHVINASDDEWWQARRV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SSGSGSLRTNQKRSLYVRAMFDYDKSKDSGLPSQGLSFKYGDILHVINASDDEWWQARRV 550 560 570 580 590 600 590 600 610 620 630 640 pF1KE5 MLEGDSEEMGVIPSKRRVERKERARLKTVKFNAKPGVIDSKGSFNDKRKKSFIFSRKFPF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MLEGDSEEMGVIPSKRRVERKERARLKTVKFNAKPGVIDSKGSFNDKRKKSFIFSRKFPF 610 620 630 640 650 660 650 660 670 680 690 700 pF1KE5 YKNKEQSEQETSDPERGQEDLILSYEPVTRQEINYTRPVIILGPMKDRINDDLISEFPDK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 YKNKEQSEQETSDPERGQEDLILSYEPVTRQEINYTRPVIILGPMKDRINDDLISEFPDK 670 680 690 700 710 720 710 720 730 740 750 760 pF1KE5 FGSCVPHTTRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYGTSVQSVRF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FGSCVPHTTRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYGTSVQSVRF 730 740 750 760 770 780 770 780 790 800 810 820 pF1KE5 VAERGKHCILDVSGNAIKRLQVAQLYPIAIFIKPRSLEPLMEMNKRLTEEQAKKTYDRAI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VAERGKHCILDVSGNAIKRLQVAQLYPIAIFIKPRSLEPLMEMNKRLTEEQAKKTYDRAI 790 800 810 820 830 840 830 840 850 860 870 pF1KE5 KLEQEFGEYFTAIVQGDTLEDIYNQCKLVIEEQSGPFIWIPSKEKL :::::::::::::::::::::::::::::::::::::::::::::: XP_011 KLEQEFGEYFTAIVQGDTLEDIYNQCKLVIEEQSGPFIWIPSKEKL 850 860 870 880 890 >>NP_001136171 (OMIM: 603583) disks large homolog 2 isof (975 aa) initn: 5685 init1: 5685 opt: 5685 Z-score: 3461.2 bits: 651.7 E(85289): 4.7e-186 Smith-Waterman score: 5685; 100.0% identity (100.0% similar) in 856 aa overlap (15-870:120-975) 10 20 30 40 pF1KE5 MFFACYCALRTNVKKYRYQDEDAPHDHSLPRLTHEVRGPELVHV :::::::::::::::::::::::::::::: NP_001 DETTTQNQGRCPAQNCSVEAPAWMPVHHCTKYRYQDEDAPHDHSLPRLTHEVRGPELVHV 90 100 110 120 130 140 50 60 70 80 90 100 pF1KE5 SEKNLSQIENVHGYVLQSHISPLKASPAPIIVNTDTLDTIPYVNGTEIEYEFEEITLERG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SEKNLSQIENVHGYVLQSHISPLKASPAPIIVNTDTLDTIPYVNGTEIEYEFEEITLERG 150 160 170 180 190 200 110 120 130 140 150 160 pF1KE5 NSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHS 210 220 230 240 250 260 170 180 190 200 210 220 pF1KE5 KAVEALKEAGSIVRLYVRRRRPILETVVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KAVEALKEAGSIVRLYVRRRRPILETVVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYV 270 280 290 300 310 320 230 240 250 260 270 280 pF1KE5 TKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKVGKPTTIYM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKVGKPTTIYM 330 340 350 360 370 380 290 300 310 320 330 340 pF1KE5 TDPYGPPDITHSYSPPMENHLLSGNNGTLEYKTSLPPISPGRYSPIPKHMLVDDDYTRPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TDPYGPPDITHSYSPPMENHLLSGNNGTLEYKTSLPPISPGRYSPIPKHMLVDDDYTRPP 390 400 410 420 430 440 350 360 370 380 390 400 pF1KE5 EPVYSTVNKLCDKPASPRHYSPVECDKSFLLSAPYSHYHLGLLPDSEMTSHSQHSTATRQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EPVYSTVNKLCDKPASPRHYSPVECDKSFLLSAPYSHYHLGLLPDSEMTSHSQHSTATRQ 450 460 470 480 490 500 410 420 430 440 450 460 pF1KE5 PSMTLQRAVSLEGEPRKVVLHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PSMTLQRAVSLEGEPRKVVLHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRG 510 520 530 540 550 560 470 480 490 500 510 520 pF1KE5 DQILSVNGIDLRGASHEQAAAALKGAGQTVTIIAQYQPEDYARFEAKIHDLREQMMNHSM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DQILSVNGIDLRGASHEQAAAALKGAGQTVTIIAQYQPEDYARFEAKIHDLREQMMNHSM 570 580 590 600 610 620 530 540 550 560 570 580 pF1KE5 SSGSGSLRTNQKRSLYVRAMFDYDKSKDSGLPSQGLSFKYGDILHVINASDDEWWQARRV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SSGSGSLRTNQKRSLYVRAMFDYDKSKDSGLPSQGLSFKYGDILHVINASDDEWWQARRV 630 640 650 660 670 680 590 600 610 620 630 640 pF1KE5 MLEGDSEEMGVIPSKRRVERKERARLKTVKFNAKPGVIDSKGSFNDKRKKSFIFSRKFPF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MLEGDSEEMGVIPSKRRVERKERARLKTVKFNAKPGVIDSKGSFNDKRKKSFIFSRKFPF 690 700 710 720 730 740 650 660 670 680 690 700 pF1KE5 YKNKEQSEQETSDPERGQEDLILSYEPVTRQEINYTRPVIILGPMKDRINDDLISEFPDK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YKNKEQSEQETSDPERGQEDLILSYEPVTRQEINYTRPVIILGPMKDRINDDLISEFPDK 750 760 770 780 790 800 710 720 730 740 750 760 pF1KE5 FGSCVPHTTRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYGTSVQSVRF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FGSCVPHTTRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYGTSVQSVRF 810 820 830 840 850 860 770 780 790 800 810 820 pF1KE5 VAERGKHCILDVSGNAIKRLQVAQLYPIAIFIKPRSLEPLMEMNKRLTEEQAKKTYDRAI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VAERGKHCILDVSGNAIKRLQVAQLYPIAIFIKPRSLEPLMEMNKRLTEEQAKKTYDRAI 870 880 890 900 910 920 830 840 850 860 870 pF1KE5 KLEQEFGEYFTAIVQGDTLEDIYNQCKLVIEEQSGPFIWIPSKEKL :::::::::::::::::::::::::::::::::::::::::::::: NP_001 KLEQEFGEYFTAIVQGDTLEDIYNQCKLVIEEQSGPFIWIPSKEKL 930 940 950 960 970 >>XP_011543080 (OMIM: 603583) PREDICTED: disks large hom (1025 aa) initn: 5685 init1: 5685 opt: 5685 Z-score: 3460.9 bits: 651.7 E(85289): 4.9e-186 Smith-Waterman score: 5685; 100.0% identity (100.0% similar) in 856 aa overlap (15-870:170-1025) 10 20 30 40 pF1KE5 MFFACYCALRTNVKKYRYQDEDAPHDHSLPRLTHEVRGPELVHV :::::::::::::::::::::::::::::: XP_011 DETTTQNQGRCPAQNCSVEAPAWMPVHHCTKYRYQDEDAPHDHSLPRLTHEVRGPELVHV 140 150 160 170 180 190 50 60 70 80 90 100 pF1KE5 SEKNLSQIENVHGYVLQSHISPLKASPAPIIVNTDTLDTIPYVNGTEIEYEFEEITLERG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SEKNLSQIENVHGYVLQSHISPLKASPAPIIVNTDTLDTIPYVNGTEIEYEFEEITLERG 200 210 220 230 240 250 110 120 130 140 150 160 pF1KE5 NSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHS 260 270 280 290 300 310 170 180 190 200 210 220 pF1KE5 KAVEALKEAGSIVRLYVRRRRPILETVVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KAVEALKEAGSIVRLYVRRRRPILETVVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYV 320 330 340 350 360 370 230 240 250 260 270 280 pF1KE5 TKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKVGKPTTIYM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKVGKPTTIYM 380 390 400 410 420 430 290 300 310 320 330 340 pF1KE5 TDPYGPPDITHSYSPPMENHLLSGNNGTLEYKTSLPPISPGRYSPIPKHMLVDDDYTRPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TDPYGPPDITHSYSPPMENHLLSGNNGTLEYKTSLPPISPGRYSPIPKHMLVDDDYTRPP 440 450 460 470 480 490 350 360 370 380 390 400 pF1KE5 EPVYSTVNKLCDKPASPRHYSPVECDKSFLLSAPYSHYHLGLLPDSEMTSHSQHSTATRQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EPVYSTVNKLCDKPASPRHYSPVECDKSFLLSAPYSHYHLGLLPDSEMTSHSQHSTATRQ 500 510 520 530 540 550 410 420 430 440 450 460 pF1KE5 PSMTLQRAVSLEGEPRKVVLHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PSMTLQRAVSLEGEPRKVVLHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRG 560 570 580 590 600 610 470 480 490 500 510 520 pF1KE5 DQILSVNGIDLRGASHEQAAAALKGAGQTVTIIAQYQPEDYARFEAKIHDLREQMMNHSM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DQILSVNGIDLRGASHEQAAAALKGAGQTVTIIAQYQPEDYARFEAKIHDLREQMMNHSM 620 630 640 650 660 670 530 540 550 560 570 580 pF1KE5 SSGSGSLRTNQKRSLYVRAMFDYDKSKDSGLPSQGLSFKYGDILHVINASDDEWWQARRV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SSGSGSLRTNQKRSLYVRAMFDYDKSKDSGLPSQGLSFKYGDILHVINASDDEWWQARRV 680 690 700 710 720 730 590 600 610 620 630 640 pF1KE5 MLEGDSEEMGVIPSKRRVERKERARLKTVKFNAKPGVIDSKGSFNDKRKKSFIFSRKFPF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MLEGDSEEMGVIPSKRRVERKERARLKTVKFNAKPGVIDSKGSFNDKRKKSFIFSRKFPF 740 750 760 770 780 790 650 660 670 680 690 700 pF1KE5 YKNKEQSEQETSDPERGQEDLILSYEPVTRQEINYTRPVIILGPMKDRINDDLISEFPDK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 YKNKEQSEQETSDPERGQEDLILSYEPVTRQEINYTRPVIILGPMKDRINDDLISEFPDK 800 810 820 830 840 850 710 720 730 740 750 760 pF1KE5 FGSCVPHTTRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYGTSVQSVRF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FGSCVPHTTRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYGTSVQSVRF 860 870 880 890 900 910 770 780 790 800 810 820 pF1KE5 VAERGKHCILDVSGNAIKRLQVAQLYPIAIFIKPRSLEPLMEMNKRLTEEQAKKTYDRAI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VAERGKHCILDVSGNAIKRLQVAQLYPIAIFIKPRSLEPLMEMNKRLTEEQAKKTYDRAI 920 930 940 950 960 970 830 840 850 860 870 pF1KE5 KLEQEFGEYFTAIVQGDTLEDIYNQCKLVIEEQSGPFIWIPSKEKL :::::::::::::::::::::::::::::::::::::::::::::: XP_011 KLEQEFGEYFTAIVQGDTLEDIYNQCKLVIEEQSGPFIWIPSKEKL 980 990 1000 1010 1020 >>XP_016872763 (OMIM: 603583) PREDICTED: disks large hom (866 aa) initn: 5555 init1: 4158 opt: 5543 Z-score: 3375.9 bits: 635.7 E(85289): 2.7e-181 Smith-Waterman score: 5543; 96.7% identity (98.0% similar) in 870 aa overlap (1-870:1-866) 10 20 30 40 50 60 pF1KE5 MFFACYCALRTNVKKYRYQDEDAPHDHSLPRLTHEVRGPELVHVSEKNLSQIENVHGYVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MFFACYCALRTNVKKYRYQDEDAPHDHSLPRLTHEVRGPELVHVSEKNLSQIENVHGYVL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE5 QSHISPLKASPAPIIVNTDTLDTIPYVNGTEIEYEFEEITLERGNSGLGFSIAGGTDNPH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QSHISPLKASPAPIIVNTDTLDTIPYVNGTEIEYEFEEITLERGNSGLGFSIAGGTDNPH 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE5 IGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLY 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE5 VRRRRPILETVVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VRRRRPILETVVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQ 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE5 VGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKVGKPTTIYMTDPYGPPDITHSYSPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKVGKPTTIYMTDPYGPPDITHSYSPP 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE5 MENHLLSGNNGTLEYKTSLPPISPGRYSPIPKHMLVDDDYTRPPEPVYSTVNKLCDKPAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MENHLLSGNNGTLEYKTSLPPISPGRYSPIPKHMLVDDDYTRPPEPVYSTVNKLCDKPAS 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE5 PRHYSPVECDKSFLLSAPYSHYHLGLLPDSEMTSHSQHSTATRQPSMTLQRAVSLEGEPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PRHYSPVECDKSFLLSAPYSHYHLGLLPDSEMTSHSQHSTATRQPSMTLQRAVSLEGEPR 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE5 KVVLHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KVVLHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASH 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE5 EQAAAALKGAGQTVTIIAQYQPEDYARFEAKIHDLREQMMNHSMSSGSGSLRTNQKRSLY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EQAAAALKGAGQTVTIIAQYQPEDYARFEAKIHDLREQMMNHSMSSGSGSLRTNQKRSLY 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE5 VRAMFDYDKSKDSGLPSQGLSFKYGDILHVINASDDEWWQARRVMLEGDSEEMGVIPSKR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VRAMFDYDKSKDSGLPSQGLSFKYGDILHVINASDDEWWQARRVMLEGDSEEMGVIPSKR 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE5 RVERKERARLKTVKFNAKPGVIDSKGSFNDKRKKSFIFSRKFPFYKNKEQSEQETSDPER ::::::::::::::::::::::::::.. .. . : . ... :..:.: : XP_016 RVERKERARLKTVKFNAKPGVIDSKGDIPGLGDDGY--GTKTLKHVSSNASDSESS--YR 610 620 630 640 650 670 680 690 700 710 720 pF1KE5 GQEDLILSYEPVTRQEINYTRPVIILGPMKDRINDDLISEFPDKFGSCVPHTTRPKRDYE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GQEDLILSYEPVTRQEINYTRPVIILGPMKDRINDDLISEFPDKFGSCVPHTTRPKRDYE 660 670 680 690 700 710 730 740 750 760 770 780 pF1KE5 VDGRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYGTSVQSVRFVAERGKHCILDVSGNA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VDGRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYGTSVQSVRFVAERGKHCILDVSGNA 720 730 740 750 760 770 790 800 810 820 830 840 pF1KE5 IKRLQVAQLYPIAIFIKPRSLEPLMEMNKRLTEEQAKKTYDRAIKLEQEFGEYFTAIVQG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IKRLQVAQLYPIAIFIKPRSLEPLMEMNKRLTEEQAKKTYDRAIKLEQEFGEYFTAIVQG 780 790 800 810 820 830 850 860 870 pF1KE5 DTLEDIYNQCKLVIEEQSGPFIWIPSKEKL :::::::::::::::::::::::::::::: XP_016 DTLEDIYNQCKLVIEEQSGPFIWIPSKEKL 840 850 860 >>NP_001193698 (OMIM: 603583) disks large homolog 2 isof (909 aa) initn: 5332 init1: 5332 opt: 5332 Z-score: 3248.0 bits: 612.2 E(85289): 3.6e-174 Smith-Waterman score: 5332; 99.8% identity (99.9% similar) in 806 aa overlap (65-870:104-909) 40 50 60 70 80 90 pF1KE5 EVRGPELVHVSEKNLSQIENVHGYVLQSHISPLKASPAPIIVNTDTLDTIPYVNGTEIEY :: .:::::::::::::::::::::::::: NP_001 WDSVRKSPHKTSTKGKGTCGEHCTCPHGWFSPAQASPAPIIVNTDTLDTIPYVNGTEIEY 80 90 100 110 120 130 100 110 120 130 140 150 pF1KE5 EFEEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EFEEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVN 140 150 160 170 180 190 160 170 180 190 200 210 pF1KE5 EVDVSEVSHSKAVEALKEAGSIVRLYVRRRRPILETVVEIKLFKGPKGLGFSIAGGVGNQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EVDVSEVSHSKAVEALKEAGSIVRLYVRRRRPILETVVEIKLFKGPKGLGFSIAGGVGNQ 200 210 220 230 240 250 220 230 240 250 260 270 pF1KE5 HIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYL 260 270 280 290 300 310 280 290 300 310 320 330 pF1KE5 KVGKPTTIYMTDPYGPPDITHSYSPPMENHLLSGNNGTLEYKTSLPPISPGRYSPIPKHM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KVGKPTTIYMTDPYGPPDITHSYSPPMENHLLSGNNGTLEYKTSLPPISPGRYSPIPKHM 320 330 340 350 360 370 340 350 360 370 380 390 pF1KE5 LVDDDYTRPPEPVYSTVNKLCDKPASPRHYSPVECDKSFLLSAPYSHYHLGLLPDSEMTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LVDDDYTRPPEPVYSTVNKLCDKPASPRHYSPVECDKSFLLSAPYSHYHLGLLPDSEMTS 380 390 400 410 420 430 400 410 420 430 440 450 pF1KE5 HSQHSTATRQPSMTLQRAVSLEGEPRKVVLHKGSTGLGFNIVGGEDGEGIFVSFILAGGP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HSQHSTATRQPSMTLQRAVSLEGEPRKVVLHKGSTGLGFNIVGGEDGEGIFVSFILAGGP 440 450 460 470 480 490 460 470 480 490 500 510 pF1KE5 ADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVTIIAQYQPEDYARFEAKIHD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVTIIAQYQPEDYARFEAKIHD 500 510 520 530 540 550 520 530 540 550 560 570 pF1KE5 LREQMMNHSMSSGSGSLRTNQKRSLYVRAMFDYDKSKDSGLPSQGLSFKYGDILHVINAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LREQMMNHSMSSGSGSLRTNQKRSLYVRAMFDYDKSKDSGLPSQGLSFKYGDILHVINAS 560 570 580 590 600 610 580 590 600 610 620 630 pF1KE5 DDEWWQARRVMLEGDSEEMGVIPSKRRVERKERARLKTVKFNAKPGVIDSKGSFNDKRKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DDEWWQARRVMLEGDSEEMGVIPSKRRVERKERARLKTVKFNAKPGVIDSKGSFNDKRKK 620 630 640 650 660 670 640 650 660 670 680 690 pF1KE5 SFIFSRKFPFYKNKEQSEQETSDPERGQEDLILSYEPVTRQEINYTRPVIILGPMKDRIN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SFIFSRKFPFYKNKEQSEQETSDPERGQEDLILSYEPVTRQEINYTRPVIILGPMKDRIN 680 690 700 710 720 730 700 710 720 730 740 750 pF1KE5 DDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIEAGQYNDNL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIEAGQYNDNL 740 750 760 770 780 790 760 770 780 790 800 810 pF1KE5 YGTSVQSVRFVAERGKHCILDVSGNAIKRLQVAQLYPIAIFIKPRSLEPLMEMNKRLTEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YGTSVQSVRFVAERGKHCILDVSGNAIKRLQVAQLYPIAIFIKPRSLEPLMEMNKRLTEE 800 810 820 830 840 850 820 830 840 850 860 870 pF1KE5 QAKKTYDRAIKLEQEFGEYFTAIVQGDTLEDIYNQCKLVIEEQSGPFIWIPSKEKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QAKKTYDRAIKLEQEFGEYFTAIVQGDTLEDIYNQCKLVIEEQSGPFIWIPSKEKL 860 870 880 890 900 >>XP_005273867 (OMIM: 603583) PREDICTED: disks large hom (837 aa) initn: 5318 init1: 5318 opt: 5318 Z-score: 3239.9 bits: 610.5 E(85289): 1e-173 Smith-Waterman score: 5318; 99.8% identity (99.9% similar) in 804 aa overlap (67-870:34-837) 40 50 60 70 80 90 pF1KE5 RGPELVHVSEKNLSQIENVHGYVLQSHISPLKASPAPIIVNTDTLDTIPYVNGTEIEYEF . :::::::::::::::::::::::::::: XP_005 PSVSRAENYQLLWDTIASLKQCEQAMQHAFIPASPAPIIVNTDTLDTIPYVNGTEIEYEF 10 20 30 40 50 60 100 110 120 130 140 150 pF1KE5 EEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEV 70 80 90 100 110 120 160 170 180 190 200 210 pF1KE5 DVSEVSHSKAVEALKEAGSIVRLYVRRRRPILETVVEIKLFKGPKGLGFSIAGGVGNQHI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DVSEVSHSKAVEALKEAGSIVRLYVRRRRPILETVVEIKLFKGPKGLGFSIAGGVGNQHI 130 140 150 160 170 180 220 230 240 250 260 270 pF1KE5 PGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKV 190 200 210 220 230 240 280 290 300 310 320 330 pF1KE5 GKPTTIYMTDPYGPPDITHSYSPPMENHLLSGNNGTLEYKTSLPPISPGRYSPIPKHMLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GKPTTIYMTDPYGPPDITHSYSPPMENHLLSGNNGTLEYKTSLPPISPGRYSPIPKHMLV 250 260 270 280 290 300 340 350 360 370 380 390 pF1KE5 DDDYTRPPEPVYSTVNKLCDKPASPRHYSPVECDKSFLLSAPYSHYHLGLLPDSEMTSHS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DDDYTRPPEPVYSTVNKLCDKPASPRHYSPVECDKSFLLSAPYSHYHLGLLPDSEMTSHS 310 320 330 340 350 360 400 410 420 430 440 450 pF1KE5 QHSTATRQPSMTLQRAVSLEGEPRKVVLHKGSTGLGFNIVGGEDGEGIFVSFILAGGPAD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QHSTATRQPSMTLQRAVSLEGEPRKVVLHKGSTGLGFNIVGGEDGEGIFVSFILAGGPAD 370 380 390 400 410 420 460 470 480 490 500 510 pF1KE5 LSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVTIIAQYQPEDYARFEAKIHDLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVTIIAQYQPEDYARFEAKIHDLR 430 440 450 460 470 480 520 530 540 550 560 570 pF1KE5 EQMMNHSMSSGSGSLRTNQKRSLYVRAMFDYDKSKDSGLPSQGLSFKYGDILHVINASDD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EQMMNHSMSSGSGSLRTNQKRSLYVRAMFDYDKSKDSGLPSQGLSFKYGDILHVINASDD 490 500 510 520 530 540 580 590 600 610 620 630 pF1KE5 EWWQARRVMLEGDSEEMGVIPSKRRVERKERARLKTVKFNAKPGVIDSKGSFNDKRKKSF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EWWQARRVMLEGDSEEMGVIPSKRRVERKERARLKTVKFNAKPGVIDSKGSFNDKRKKSF 550 560 570 580 590 600 640 650 660 670 680 690 pF1KE5 IFSRKFPFYKNKEQSEQETSDPERGQEDLILSYEPVTRQEINYTRPVIILGPMKDRINDD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 IFSRKFPFYKNKEQSEQETSDPERGQEDLILSYEPVTRQEINYTRPVIILGPMKDRINDD 610 620 630 640 650 660 700 710 720 730 740 750 pF1KE5 LISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYG 670 680 690 700 710 720 760 770 780 790 800 810 pF1KE5 TSVQSVRFVAERGKHCILDVSGNAIKRLQVAQLYPIAIFIKPRSLEPLMEMNKRLTEEQA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TSVQSVRFVAERGKHCILDVSGNAIKRLQVAQLYPIAIFIKPRSLEPLMEMNKRLTEEQA 730 740 750 760 770 780 820 830 840 850 860 870 pF1KE5 KKTYDRAIKLEQEFGEYFTAIVQGDTLEDIYNQCKLVIEEQSGPFIWIPSKEKL :::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KKTYDRAIKLEQEFGEYFTAIVQGDTLEDIYNQCKLVIEEQSGPFIWIPSKEKL 790 800 810 820 830 >>XP_016872771 (OMIM: 603583) PREDICTED: disks large hom (811 aa) initn: 5082 init1: 5082 opt: 5082 Z-score: 3097.3 bits: 584.1 E(85289): 8.8e-166 Smith-Waterman score: 5082; 99.7% identity (99.9% similar) in 769 aa overlap (67-835:34-802) 40 50 60 70 80 90 pF1KE5 RGPELVHVSEKNLSQIENVHGYVLQSHISPLKASPAPIIVNTDTLDTIPYVNGTEIEYEF . :::::::::::::::::::::::::::: XP_016 PSVSRAENYQLLWDTIASLKQCEQAMQHAFIPASPAPIIVNTDTLDTIPYVNGTEIEYEF 10 20 30 40 50 60 100 110 120 130 140 150 pF1KE5 EEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEV 70 80 90 100 110 120 160 170 180 190 200 210 pF1KE5 DVSEVSHSKAVEALKEAGSIVRLYVRRRRPILETVVEIKLFKGPKGLGFSIAGGVGNQHI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DVSEVSHSKAVEALKEAGSIVRLYVRRRRPILETVVEIKLFKGPKGLGFSIAGGVGNQHI 130 140 150 160 170 180 220 230 240 250 260 270 pF1KE5 PGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKV 190 200 210 220 230 240 280 290 300 310 320 330 pF1KE5 GKPTTIYMTDPYGPPDITHSYSPPMENHLLSGNNGTLEYKTSLPPISPGRYSPIPKHMLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GKPTTIYMTDPYGPPDITHSYSPPMENHLLSGNNGTLEYKTSLPPISPGRYSPIPKHMLV 250 260 270 280 290 300 340 350 360 370 380 390 pF1KE5 DDDYTRPPEPVYSTVNKLCDKPASPRHYSPVECDKSFLLSAPYSHYHLGLLPDSEMTSHS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DDDYTRPPEPVYSTVNKLCDKPASPRHYSPVECDKSFLLSAPYSHYHLGLLPDSEMTSHS 310 320 330 340 350 360 400 410 420 430 440 450 pF1KE5 QHSTATRQPSMTLQRAVSLEGEPRKVVLHKGSTGLGFNIVGGEDGEGIFVSFILAGGPAD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QHSTATRQPSMTLQRAVSLEGEPRKVVLHKGSTGLGFNIVGGEDGEGIFVSFILAGGPAD 370 380 390 400 410 420 460 470 480 490 500 510 pF1KE5 LSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVTIIAQYQPEDYARFEAKIHDLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVTIIAQYQPEDYARFEAKIHDLR 430 440 450 460 470 480 520 530 540 550 560 570 pF1KE5 EQMMNHSMSSGSGSLRTNQKRSLYVRAMFDYDKSKDSGLPSQGLSFKYGDILHVINASDD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EQMMNHSMSSGSGSLRTNQKRSLYVRAMFDYDKSKDSGLPSQGLSFKYGDILHVINASDD 490 500 510 520 530 540 580 590 600 610 620 630 pF1KE5 EWWQARRVMLEGDSEEMGVIPSKRRVERKERARLKTVKFNAKPGVIDSKGSFNDKRKKSF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EWWQARRVMLEGDSEEMGVIPSKRRVERKERARLKTVKFNAKPGVIDSKGSFNDKRKKSF 550 560 570 580 590 600 640 650 660 670 680 690 pF1KE5 IFSRKFPFYKNKEQSEQETSDPERGQEDLILSYEPVTRQEINYTRPVIILGPMKDRINDD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IFSRKFPFYKNKEQSEQETSDPERGQEDLILSYEPVTRQEINYTRPVIILGPMKDRINDD 610 620 630 640 650 660 700 710 720 730 740 750 pF1KE5 LISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYG 670 680 690 700 710 720 760 770 780 790 800 810 pF1KE5 TSVQSVRFVAERGKHCILDVSGNAIKRLQVAQLYPIAIFIKPRSLEPLMEMNKRLTEEQA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TSVQSVRFVAERGKHCILDVSGNAIKRLQVAQLYPIAIFIKPRSLEPLMEMNKRLTEEQA 730 740 750 760 770 780 820 830 840 850 860 870 pF1KE5 KKTYDRAIKLEQEFGEYFTAIVQGDTLEDIYNQCKLVIEEQSGPFIWIPSKEKL ::::::::::::::::::: XP_016 KKTYDRAIKLEQEFGEYFTGKFTFTLVV 790 800 810 >>XP_016872756 (OMIM: 603583) PREDICTED: disks large hom (884 aa) initn: 6188 init1: 4380 opt: 4380 Z-score: 2672.1 bits: 505.6 E(85289): 4.2e-142 Smith-Waterman score: 5749; 98.4% identity (98.4% similar) in 884 aa overlap (1-870:1-884) 10 20 30 40 50 60 pF1KE5 MFFACYCALRTNVKKYRYQDEDAPHDHSLPRLTHEVRGPELVHVSEKNLSQIENVHGYVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MFFACYCALRTNVKKYRYQDEDAPHDHSLPRLTHEVRGPELVHVSEKNLSQIENVHGYVL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE5 QSHISPLKASPAPIIVNTDTLDTIPYVNGTEIEYEFEEITLERGNSGLGFSIAGGTDNPH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QSHISPLKASPAPIIVNTDTLDTIPYVNGTEIEYEFEEITLERGNSGLGFSIAGGTDNPH 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE5 IGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLY 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE5 VRRRRPILETVVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VRRRRPILETVVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQ 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE5 VGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKVGKPTTIYMTDPYGPPDITHSYSPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKVGKPTTIYMTDPYGPPDITHSYSPP 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE5 MENHLLSGNNGTLEYKTSLPPISPGRYSPIPKHMLVDDDYTRPPEPVYSTVNKLCDKPAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MENHLLSGNNGTLEYKTSLPPISPGRYSPIPKHMLVDDDYTRPPEPVYSTVNKLCDKPAS 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE5 PRHYSPVECDKSFLLSAPYSHYHLGLLPDSEMTSHSQHSTATRQPSMTLQRAVSLEGEPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PRHYSPVECDKSFLLSAPYSHYHLGLLPDSEMTSHSQHSTATRQPSMTLQRAVSLEGEPR 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE5 KVVLHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KVVLHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASH 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE5 EQAAAALKGAGQTVTIIAQYQPEDYARFEAKIHDLREQMMNHSMSSGSGSLRTNQKRSLY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EQAAAALKGAGQTVTIIAQYQPEDYARFEAKIHDLREQMMNHSMSSGSGSLRTNQKRSLY 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE5 VRAMFDYDKSKDSGLPSQGLSFKYGDILHVINASDDEWWQARRVMLEGDSEEMGVIPSKR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VRAMFDYDKSKDSGLPSQGLSFKYGDILHVINASDDEWWQARRVMLEGDSEEMGVIPSKR 550 560 570 580 590 600 610 620 630 640 650 pF1KE5 RVERKERARLKTVKFNAKPGVIDSKGSFNDKRKKSFIFSRKFPFYKNKEQSEQETSDPE- ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RVERKERARLKTVKFNAKPGVIDSKGSFNDKRKKSFIFSRKFPFYKNKEQSEQETSDPEQ 610 620 630 640 650 660 660 670 680 690 700 pF1KE5 -------------RGQEDLILSYEPVTRQEINYTRPVIILGPMKDRINDDLISEFPDKFG ::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HVSSNASDSESSYRGQEDLILSYEPVTRQEINYTRPVIILGPMKDRINDDLISEFPDKFG 670 680 690 700 710 720 710 720 730 740 750 760 pF1KE5 SCVPHTTRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYGTSVQSVRFVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SCVPHTTRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYGTSVQSVRFVA 730 740 750 760 770 780 770 780 790 800 810 820 pF1KE5 ERGKHCILDVSGNAIKRLQVAQLYPIAIFIKPRSLEPLMEMNKRLTEEQAKKTYDRAIKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ERGKHCILDVSGNAIKRLQVAQLYPIAIFIKPRSLEPLMEMNKRLTEEQAKKTYDRAIKL 790 800 810 820 830 840 830 840 850 860 870 pF1KE5 EQEFGEYFTAIVQGDTLEDIYNQCKLVIEEQSGPFIWIPSKEKL :::::::::::::::::::::::::::::::::::::::::::: XP_016 EQEFGEYFTAIVQGDTLEDIYNQCKLVIEEQSGPFIWIPSKEKL 850 860 870 880 >>XP_016872757 (OMIM: 603583) PREDICTED: disks large hom (883 aa) initn: 6174 init1: 4278 opt: 4362 Z-score: 2661.3 bits: 503.6 E(85289): 1.7e-141 Smith-Waterman score: 5731; 98.3% identity (98.3% similar) in 884 aa overlap (1-870:1-883) 10 20 30 40 50 60 pF1KE5 MFFACYCALRTNVKKYRYQDEDAPHDHSLPRLTHEVRGPELVHVSEKNLSQIENVHGYVL :::::::::::::: ::::::::::::::::::::::::::::::::::::::::::::: XP_016 MFFACYCALRTNVK-YRYQDEDAPHDHSLPRLTHEVRGPELVHVSEKNLSQIENVHGYVL 10 20 30 40 50 70 80 90 100 110 120 pF1KE5 QSHISPLKASPAPIIVNTDTLDTIPYVNGTEIEYEFEEITLERGNSGLGFSIAGGTDNPH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QSHISPLKASPAPIIVNTDTLDTIPYVNGTEIEYEFEEITLERGNSGLGFSIAGGTDNPH 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE5 IGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLY 120 130 140 150 160 170 190 200 210 220 230 240 pF1KE5 VRRRRPILETVVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VRRRRPILETVVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQ 180 190 200 210 220 230 250 260 270 280 290 300 pF1KE5 VGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKVGKPTTIYMTDPYGPPDITHSYSPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKVGKPTTIYMTDPYGPPDITHSYSPP 240 250 260 270 280 290 310 320 330 340 350 360 pF1KE5 MENHLLSGNNGTLEYKTSLPPISPGRYSPIPKHMLVDDDYTRPPEPVYSTVNKLCDKPAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MENHLLSGNNGTLEYKTSLPPISPGRYSPIPKHMLVDDDYTRPPEPVYSTVNKLCDKPAS 300 310 320 330 340 350 370 380 390 400 410 420 pF1KE5 PRHYSPVECDKSFLLSAPYSHYHLGLLPDSEMTSHSQHSTATRQPSMTLQRAVSLEGEPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PRHYSPVECDKSFLLSAPYSHYHLGLLPDSEMTSHSQHSTATRQPSMTLQRAVSLEGEPR 360 370 380 390 400 410 430 440 450 460 470 480 pF1KE5 KVVLHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KVVLHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASH 420 430 440 450 460 470 490 500 510 520 530 540 pF1KE5 EQAAAALKGAGQTVTIIAQYQPEDYARFEAKIHDLREQMMNHSMSSGSGSLRTNQKRSLY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EQAAAALKGAGQTVTIIAQYQPEDYARFEAKIHDLREQMMNHSMSSGSGSLRTNQKRSLY 480 490 500 510 520 530 550 560 570 580 590 600 pF1KE5 VRAMFDYDKSKDSGLPSQGLSFKYGDILHVINASDDEWWQARRVMLEGDSEEMGVIPSKR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VRAMFDYDKSKDSGLPSQGLSFKYGDILHVINASDDEWWQARRVMLEGDSEEMGVIPSKR 540 550 560 570 580 590 610 620 630 640 650 pF1KE5 RVERKERARLKTVKFNAKPGVIDSKGSFNDKRKKSFIFSRKFPFYKNKEQSEQETSDPE- ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RVERKERARLKTVKFNAKPGVIDSKGSFNDKRKKSFIFSRKFPFYKNKEQSEQETSDPEQ 600 610 620 630 640 650 660 670 680 690 700 pF1KE5 -------------RGQEDLILSYEPVTRQEINYTRPVIILGPMKDRINDDLISEFPDKFG ::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HVSSNASDSESSYRGQEDLILSYEPVTRQEINYTRPVIILGPMKDRINDDLISEFPDKFG 660 670 680 690 700 710 710 720 730 740 750 760 pF1KE5 SCVPHTTRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYGTSVQSVRFVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SCVPHTTRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYGTSVQSVRFVA 720 730 740 750 760 770 770 780 790 800 810 820 pF1KE5 ERGKHCILDVSGNAIKRLQVAQLYPIAIFIKPRSLEPLMEMNKRLTEEQAKKTYDRAIKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ERGKHCILDVSGNAIKRLQVAQLYPIAIFIKPRSLEPLMEMNKRLTEEQAKKTYDRAIKL 780 790 800 810 820 830 830 840 850 860 870 pF1KE5 EQEFGEYFTAIVQGDTLEDIYNQCKLVIEEQSGPFIWIPSKEKL :::::::::::::::::::::::::::::::::::::::::::: XP_016 EQEFGEYFTAIVQGDTLEDIYNQCKLVIEEQSGPFIWIPSKEKL 840 850 860 870 880 870 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Nov 8 06:05:13 2016 done: Tue Nov 8 06:05:15 2016 Total Scan time: 8.570 Total Display time: 0.190 Function used was FASTA [36.3.4 Apr, 2011]