FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE3957, 341 aa 1>>>pF1KE3957 341 - 341 aa - 341 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 7.7270+/-0.000398; mu= 3.8750+/- 0.025 mean_var=128.0869+/-25.532, 0's: 0 Z-trim(115.2): 196 B-trim: 357 in 1/56 Lambda= 0.113324 statistics sampled from 25345 (25542) to 25345 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.676), E-opt: 0.2 (0.299), width: 16 Scan time: 7.170 The best scores are: opt bits E(85289) NP_542783 (OMIM: 616017) E3 ubiquitin-protein liga ( 341) 2267 382.0 9.8e-106 NP_892030 (OMIM: 616017) E3 ubiquitin-protein liga ( 500) 2254 380.0 6e-105 NP_001288073 (OMIM: 616017) E3 ubiquitin-protein l ( 296) 1989 336.6 4.2e-92 NP_001288075 (OMIM: 616017) E3 ubiquitin-protein l ( 263) 1583 270.2 3.6e-72 NP_001288074 (OMIM: 616017) E3 ubiquitin-protein l ( 279) 1577 269.2 7.5e-72 NP_742013 (OMIM: 605700) E3 ubiquitin-protein liga ( 488) 663 119.9 1.2e-26 NP_060677 (OMIM: 616755) E3 ubiquitin-protein liga ( 475) 635 115.3 2.7e-25 XP_016857118 (OMIM: 616755) PREDICTED: E3 ubiquiti ( 555) 635 115.3 3.1e-25 NP_001317412 (OMIM: 616755) E3 ubiquitin-protein l ( 354) 630 114.4 3.7e-25 XP_016857119 (OMIM: 616755) PREDICTED: E3 ubiquiti ( 544) 607 110.7 7.4e-24 NP_001017922 (OMIM: 111620,111750,609017) erythroi ( 475) 586 107.3 7.1e-23 XP_006710376 (OMIM: 111620,111750,609017) PREDICTE ( 475) 586 107.3 7.1e-23 NP_061008 (OMIM: 111620,111750,609017) erythroid m ( 475) 586 107.3 7.1e-23 XP_011538872 (OMIM: 111620,111750,609017) PREDICTE ( 475) 586 107.3 7.1e-23 XP_011538873 (OMIM: 111620,111750,609017) PREDICTE ( 468) 573 105.1 3.1e-22 NP_067076 (OMIM: 605700) E3 ubiquitin-protein liga ( 518) 568 104.3 5.9e-22 NP_835226 (OMIM: 612548) E3 ubiquitin-protein liga ( 487) 538 99.4 1.7e-20 NP_001268380 (OMIM: 612548) E3 ubiquitin-protein l ( 487) 538 99.4 1.7e-20 NP_001268379 (OMIM: 612548) E3 ubiquitin-protein l ( 486) 537 99.3 1.9e-20 XP_011514091 (OMIM: 612548) PREDICTED: E3 ubiquiti ( 486) 537 99.3 1.9e-20 NP_976038 (OMIM: 609315) tripartite motif-containi ( 511) 536 99.1 2.2e-20 NP_976041 (OMIM: 609315) tripartite motif-containi ( 303) 527 97.5 3.8e-20 NP_976040 (OMIM: 609315) tripartite motif-containi ( 303) 527 97.5 3.8e-20 NP_976039 (OMIM: 609315) tripartite motif-containi ( 303) 527 97.5 3.8e-20 XP_016865392 (OMIM: 609315) PREDICTED: tripartite ( 303) 527 97.5 3.8e-20 NP_976042 (OMIM: 609315) tripartite motif-containi ( 329) 527 97.6 4.1e-20 XP_011514090 (OMIM: 612548) PREDICTED: E3 ubiquiti ( 278) 509 94.6 2.7e-19 XP_016878725 (OMIM: 134610,249100,608107) PREDICTE ( 780) 504 93.9 1.2e-18 NP_000234 (OMIM: 134610,249100,608107) pyrin isofo ( 781) 504 93.9 1.2e-18 NP_006501 (OMIM: 602165) zinc finger protein RFP [ ( 513) 499 93.1 1.5e-18 NP_003132 (OMIM: 109092) E3 ubiquitin-protein liga ( 475) 498 92.9 1.5e-18 NP_001723 (OMIM: 601610) butyrophilin subfamily 1 ( 526) 480 90.0 1.3e-17 XP_005249397 (OMIM: 601610) PREDICTED: butyrophili ( 626) 480 90.0 1.5e-17 XP_006715046 (OMIM: 613593) PREDICTED: butyrophili ( 419) 475 89.1 1.8e-17 NP_001138480 (OMIM: 613593) butyrophilin subfamily ( 461) 475 89.1 2e-17 NP_008979 (OMIM: 613593) butyrophilin subfamily 3 ( 513) 475 89.1 2.2e-17 NP_001184168 (OMIM: 613591) butyrophilin subfamily ( 313) 471 88.4 2.2e-17 XP_011512533 (OMIM: 613591) PREDICTED: butyrophili ( 313) 471 88.4 2.2e-17 NP_853509 (OMIM: 613591) butyrophilin subfamily 2 ( 407) 471 88.4 2.8e-17 XP_016865656 (OMIM: 613591) PREDICTED: butyrophili ( 407) 471 88.4 2.8e-17 XP_005248855 (OMIM: 613591) PREDICTED: butyrophili ( 407) 471 88.4 2.8e-17 XP_011512531 (OMIM: 613591) PREDICTED: butyrophili ( 461) 471 88.5 3.2e-17 XP_016865655 (OMIM: 613591) PREDICTED: butyrophili ( 461) 471 88.5 3.2e-17 NP_001184162 (OMIM: 613590) butyrophilin subfamily ( 466) 471 88.5 3.2e-17 XP_005248854 (OMIM: 613591) PREDICTED: butyrophili ( 523) 471 88.5 3.5e-17 XP_006715016 (OMIM: 613591) PREDICTED: butyrophili ( 523) 471 88.5 3.5e-17 XP_011512530 (OMIM: 613591) PREDICTED: butyrophili ( 523) 471 88.5 3.5e-17 NP_008926 (OMIM: 613591) butyrophilin subfamily 2 ( 523) 471 88.5 3.5e-17 NP_001184166 (OMIM: 613591) butyrophilin subfamily ( 523) 471 88.5 3.5e-17 NP_008980 (OMIM: 613590) butyrophilin subfamily 2 ( 527) 471 88.5 3.5e-17 >>NP_542783 (OMIM: 616017) E3 ubiquitin-protein ligase T (341 aa) initn: 2267 init1: 2267 opt: 2267 Z-score: 2019.2 bits: 382.0 E(85289): 9.8e-106 Smith-Waterman score: 2267; 100.0% identity (100.0% similar) in 341 aa overlap (1-341:1-341) 10 20 30 40 50 60 pF1KE3 MEEELAIQQGQLETTLKELQTLRNMQKEAIAAHKENKLHLQQHVSMEFLKLHQFLHSKEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_542 MEEELAIQQGQLETTLKELQTLRNMQKEAIAAHKENKLHLQQHVSMEFLKLHQFLHSKEK 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 DILTELREEGKALNEEMELNLSQLQEQCLLAKDMLVSIQAKTEQQNSFDFLKDITTLLHS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_542 DILTELREEGKALNEEMELNLSQLQEQCLLAKDMLVSIQAKTEQQNSFDFLKDITTLLHS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 LEQGMKVLATRELISRKLNLGQYKGPIQYMVWREMQDTLCPGLSPLTLDPKTAHPNLVLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_542 LEQGMKVLATRELISRKLNLGQYKGPIQYMVWREMQDTLCPGLSPLTLDPKTAHPNLVLS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 KSQTSVWHGDIKKIMPDDPERFDSSVAVLGSRGFTSGKWYWEVEVAKKTKWTVGVVRESI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_542 KSQTSVWHGDIKKIMPDDPERFDSSVAVLGSRGFTSGKWYWEVEVAKKTKWTVGVVRESI 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 IRKGSCPLTPEQGFWLLRLRNQTDLKALDLPSFSLTLTNNLDKVGIYLDYEGGQLSFYNA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_542 IRKGSCPLTPEQGFWLLRLRNQTDLKALDLPSFSLTLTNNLDKVGIYLDYEGGQLSFYNA 250 260 270 280 290 300 310 320 330 340 pF1KE3 KTMTHIYTFSNTFMEKLYPYFCPCLNDGGENKEPLHILHPQ ::::::::::::::::::::::::::::::::::::::::: NP_542 KTMTHIYTFSNTFMEKLYPYFCPCLNDGGENKEPLHILHPQ 310 320 330 340 >>NP_892030 (OMIM: 616017) E3 ubiquitin-protein ligase T (500 aa) initn: 2254 init1: 2254 opt: 2254 Z-score: 2005.1 bits: 380.0 E(85289): 6e-105 Smith-Waterman score: 2254; 100.0% identity (100.0% similar) in 339 aa overlap (3-341:162-500) 10 20 30 pF1KE3 MEEELAIQQGQLETTLKELQTLRNMQKEAIAA :::::::::::::::::::::::::::::: NP_892 LICFQCKDARLSVGQSKEFLQISDAVHFFTEELAIQQGQLETTLKELQTLRNMQKEAIAA 140 150 160 170 180 190 40 50 60 70 80 90 pF1KE3 HKENKLHLQQHVSMEFLKLHQFLHSKEKDILTELREEGKALNEEMELNLSQLQEQCLLAK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_892 HKENKLHLQQHVSMEFLKLHQFLHSKEKDILTELREEGKALNEEMELNLSQLQEQCLLAK 200 210 220 230 240 250 100 110 120 130 140 150 pF1KE3 DMLVSIQAKTEQQNSFDFLKDITTLLHSLEQGMKVLATRELISRKLNLGQYKGPIQYMVW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_892 DMLVSIQAKTEQQNSFDFLKDITTLLHSLEQGMKVLATRELISRKLNLGQYKGPIQYMVW 260 270 280 290 300 310 160 170 180 190 200 210 pF1KE3 REMQDTLCPGLSPLTLDPKTAHPNLVLSKSQTSVWHGDIKKIMPDDPERFDSSVAVLGSR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_892 REMQDTLCPGLSPLTLDPKTAHPNLVLSKSQTSVWHGDIKKIMPDDPERFDSSVAVLGSR 320 330 340 350 360 370 220 230 240 250 260 270 pF1KE3 GFTSGKWYWEVEVAKKTKWTVGVVRESIIRKGSCPLTPEQGFWLLRLRNQTDLKALDLPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_892 GFTSGKWYWEVEVAKKTKWTVGVVRESIIRKGSCPLTPEQGFWLLRLRNQTDLKALDLPS 380 390 400 410 420 430 280 290 300 310 320 330 pF1KE3 FSLTLTNNLDKVGIYLDYEGGQLSFYNAKTMTHIYTFSNTFMEKLYPYFCPCLNDGGENK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_892 FSLTLTNNLDKVGIYLDYEGGQLSFYNAKTMTHIYTFSNTFMEKLYPYFCPCLNDGGENK 440 450 460 470 480 490 340 pF1KE3 EPLHILHPQ ::::::::: NP_892 EPLHILHPQ 500 >>NP_001288073 (OMIM: 616017) E3 ubiquitin-protein ligas (296 aa) initn: 1989 init1: 1989 opt: 1989 Z-score: 1774.6 bits: 336.6 E(85289): 4.2e-92 Smith-Waterman score: 1989; 100.0% identity (100.0% similar) in 296 aa overlap (46-341:1-296) 20 30 40 50 60 70 pF1KE3 LKELQTLRNMQKEAIAAHKENKLHLQQHVSMEFLKLHQFLHSKEKDILTELREEGKALNE :::::::::::::::::::::::::::::: NP_001 MEFLKLHQFLHSKEKDILTELREEGKALNE 10 20 30 80 90 100 110 120 130 pF1KE3 EMELNLSQLQEQCLLAKDMLVSIQAKTEQQNSFDFLKDITTLLHSLEQGMKVLATRELIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EMELNLSQLQEQCLLAKDMLVSIQAKTEQQNSFDFLKDITTLLHSLEQGMKVLATRELIS 40 50 60 70 80 90 140 150 160 170 180 190 pF1KE3 RKLNLGQYKGPIQYMVWREMQDTLCPGLSPLTLDPKTAHPNLVLSKSQTSVWHGDIKKIM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RKLNLGQYKGPIQYMVWREMQDTLCPGLSPLTLDPKTAHPNLVLSKSQTSVWHGDIKKIM 100 110 120 130 140 150 200 210 220 230 240 250 pF1KE3 PDDPERFDSSVAVLGSRGFTSGKWYWEVEVAKKTKWTVGVVRESIIRKGSCPLTPEQGFW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PDDPERFDSSVAVLGSRGFTSGKWYWEVEVAKKTKWTVGVVRESIIRKGSCPLTPEQGFW 160 170 180 190 200 210 260 270 280 290 300 310 pF1KE3 LLRLRNQTDLKALDLPSFSLTLTNNLDKVGIYLDYEGGQLSFYNAKTMTHIYTFSNTFME :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LLRLRNQTDLKALDLPSFSLTLTNNLDKVGIYLDYEGGQLSFYNAKTMTHIYTFSNTFME 220 230 240 250 260 270 320 330 340 pF1KE3 KLYPYFCPCLNDGGENKEPLHILHPQ :::::::::::::::::::::::::: NP_001 KLYPYFCPCLNDGGENKEPLHILHPQ 280 290 >>NP_001288075 (OMIM: 616017) E3 ubiquitin-protein ligas (263 aa) initn: 1573 init1: 1573 opt: 1583 Z-score: 1416.6 bits: 270.2 E(85289): 3.6e-72 Smith-Waterman score: 1606; 77.1% identity (77.1% similar) in 341 aa overlap (1-341:1-263) 10 20 30 40 50 60 pF1KE3 MEEELAIQQGQLETTLKELQTLRNMQKEAIAAHKENKLHLQQHVSMEFLKLHQFLHSKEK :::::::::::::::::::::::::::::::::: NP_001 MEEELAIQQGQLETTLKELQTLRNMQKEAIAAHK-------------------------- 10 20 30 70 80 90 100 110 120 pF1KE3 DILTELREEGKALNEEMELNLSQLQEQCLLAKDMLVSIQAKTEQQNSFDFLKDITTLLHS :::::::: NP_001 ----------------------------------------------------DITTLLHS 40 130 140 150 160 170 180 pF1KE3 LEQGMKVLATRELISRKLNLGQYKGPIQYMVWREMQDTLCPGLSPLTLDPKTAHPNLVLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LEQGMKVLATRELISRKLNLGQYKGPIQYMVWREMQDTLCPGLSPLTLDPKTAHPNLVLS 50 60 70 80 90 100 190 200 210 220 230 240 pF1KE3 KSQTSVWHGDIKKIMPDDPERFDSSVAVLGSRGFTSGKWYWEVEVAKKTKWTVGVVRESI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KSQTSVWHGDIKKIMPDDPERFDSSVAVLGSRGFTSGKWYWEVEVAKKTKWTVGVVRESI 110 120 130 140 150 160 250 260 270 280 290 300 pF1KE3 IRKGSCPLTPEQGFWLLRLRNQTDLKALDLPSFSLTLTNNLDKVGIYLDYEGGQLSFYNA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IRKGSCPLTPEQGFWLLRLRNQTDLKALDLPSFSLTLTNNLDKVGIYLDYEGGQLSFYNA 170 180 190 200 210 220 310 320 330 340 pF1KE3 KTMTHIYTFSNTFMEKLYPYFCPCLNDGGENKEPLHILHPQ ::::::::::::::::::::::::::::::::::::::::: NP_001 KTMTHIYTFSNTFMEKLYPYFCPCLNDGGENKEPLHILHPQ 230 240 250 260 >>NP_001288074 (OMIM: 616017) E3 ubiquitin-protein ligas (279 aa) initn: 1567 init1: 1567 opt: 1577 Z-score: 1410.9 bits: 269.2 E(85289): 7.5e-72 Smith-Waterman score: 1840; 94.3% identity (94.3% similar) in 296 aa overlap (46-341:1-279) 20 30 40 50 60 70 pF1KE3 LKELQTLRNMQKEAIAAHKENKLHLQQHVSMEFLKLHQFLHSKEKDILTELREEGKALNE :::::::::::::::::::::::::::::: NP_001 MEFLKLHQFLHSKEKDILTELREEGKALNE 10 20 30 80 90 100 110 120 130 pF1KE3 EMELNLSQLQEQCLLAKDMLVSIQAKTEQQNSFDFLKDITTLLHSLEQGMKVLATRELIS :::::::::::::::::::: ::::::::::::::::::::::: NP_001 EMELNLSQLQEQCLLAKDML-----------------DITTLLHSLEQGMKVLATRELIS 40 50 60 70 140 150 160 170 180 190 pF1KE3 RKLNLGQYKGPIQYMVWREMQDTLCPGLSPLTLDPKTAHPNLVLSKSQTSVWHGDIKKIM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RKLNLGQYKGPIQYMVWREMQDTLCPGLSPLTLDPKTAHPNLVLSKSQTSVWHGDIKKIM 80 90 100 110 120 130 200 210 220 230 240 250 pF1KE3 PDDPERFDSSVAVLGSRGFTSGKWYWEVEVAKKTKWTVGVVRESIIRKGSCPLTPEQGFW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PDDPERFDSSVAVLGSRGFTSGKWYWEVEVAKKTKWTVGVVRESIIRKGSCPLTPEQGFW 140 150 160 170 180 190 260 270 280 290 300 310 pF1KE3 LLRLRNQTDLKALDLPSFSLTLTNNLDKVGIYLDYEGGQLSFYNAKTMTHIYTFSNTFME :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LLRLRNQTDLKALDLPSFSLTLTNNLDKVGIYLDYEGGQLSFYNAKTMTHIYTFSNTFME 200 210 220 230 240 250 320 330 340 pF1KE3 KLYPYFCPCLNDGGENKEPLHILHPQ :::::::::::::::::::::::::: NP_001 KLYPYFCPCLNDGGENKEPLHILHPQ 260 270 >>NP_742013 (OMIM: 605700) E3 ubiquitin-protein ligase T (488 aa) initn: 607 init1: 454 opt: 663 Z-score: 599.5 bits: 119.9 E(85289): 1.2e-26 Smith-Waterman score: 663; 36.1% identity (63.6% similar) in 330 aa overlap (12-340:161-484) 10 20 30 40 pF1KE3 MEEELAIQQGQLETTLKELQTLRNMQKEAIAAHKENKLHLQ :: :.:. .. ... . :. . NP_742 ISHTHRAHTVVPLDDATQEYKEKLQKCLEPLEQKLQEITRCKSSEEKKPGELKRLVESRR 140 150 160 170 180 190 50 60 70 80 90 100 pF1KE3 QHVSMEFLKLHQFLHSKEKDILTELREEGKALNEEMELNLSQLQEQCLLAKDMLVSIQAK :.. :: .::. : ... .:..:.:: . . .... : ..: .. . . ...: NP_742 QQILREFEELHRRLDEEQQVLLSRLEEEEQDILQRLRENAAHLGDKRRDLAHLAAEVEGK 200 210 220 230 240 250 110 120 130 140 150 160 pF1KE3 TEQQNSFDFLKDITTLLHSLEQGMKVLATRELISRKLNLGQYKGPIQYMVWREMQDTLCP :..:..:::. . :.. :. . .: : . :.... : ::.. :.. : NP_742 C-LQSGFEMLKDVKSTLEKCEKVKTMEVTSVSIELEKNFSNF--PRQYFALRKILKQL-- 260 270 280 290 300 170 180 190 200 210 220 pF1KE3 GLSPLTLDPKTAHPNLVLSKSQTSVWHGDIK-KIMPDDPERFDSSVAVLGSRGFTSGKWY .. .::::.:::::::::... :: . . . .:: :.:: ::...:::::. : NP_742 -IADVTLDPETAHPNLVLSEDRKSVKFVETRLRDLPDTPRRFTFYPCVLATEGFTSGRHY 310 320 330 340 350 360 230 240 250 260 270 280 pF1KE3 WEVEVAKKTKWTVGVVRESIIRKGSCPLTPEQGFWLLRLRNQTDLKALDLPSFSLTLTNN :::::. ::.:.::: :.:. ::: :: :.: .:: : : : : . . NP_742 WEVEVGDKTHWAVGVCRDSVSRKGELTPLPETGYWRVRLWNGDKYAATTTPFTPLHIKVK 370 380 390 400 410 420 290 300 310 320 330 340 pF1KE3 LDKVGIYLDYEGGQLSFYNAKTMTHIYTFSNTFMEKLYPYFCPCLNDGGENKEPLHILHP .:::.::::.: :::::. .:::::..:: :::.: : : . : .: :: : : NP_742 PKRVGIFLDYEAGTLSFYNVTDRSHIYTFTDTFTEKLWPLFYPGIRAGRKNAAPLTIRPP 430 440 450 460 470 480 pF1KE3 Q NP_742 TDWE >>NP_060677 (OMIM: 616755) E3 ubiquitin-protein ligase T (475 aa) initn: 524 init1: 368 opt: 635 Z-score: 575.0 bits: 115.3 E(85289): 2.7e-25 Smith-Waterman score: 635; 33.0% identity (63.4% similar) in 339 aa overlap (1-337:135-470) 10 20 30 pF1KE3 MEEELAIQQGQLETTLKELQTLRNMQKEAI ...:: : :. . .: .. :. . NP_060 TDRALLCFFCDEPALHEQHQVTGIDDAFDELQRELKDQLQALQDSEREHTEALQLLKRQL 110 120 130 140 150 160 40 50 60 70 80 90 pF1KE3 AAHKENKLHLQQHVSMEFLKLHQFLHSKEKDILTELREEGKALNEEMELNLSQLQEQCLL : : . :. .. : .::..:. ..: .: ::. . ..: .... ..: NP_060 AETKSSTKSLRTTIGEAFERLHRLLRERQKAMLEELEADTARTLTDIEQKVQRYSQQLRK 170 180 190 200 210 220 100 110 120 130 140 150 pF1KE3 AKDMLVSIQAKTEQQNSFDFLKDITTLLHSLEQGMKVLATRELISRKLNLGQYKGPIQYM ... .: . . . :: ...: . : .: :. : .: . . ..: ::.:: NP_060 VQEGAQILQERLAETDRHTFLAGVASLSERL-KG-KIHET-NLTYEDFPTSKYTGPLQYT 230 240 250 260 270 280 160 170 180 190 200 pF1KE3 VWREMQDTLCPGLSPLTLDPKTAHPNLVLSKSQTSVWHGDIK-KIMPDDPERFDSSVAVL .:. . . . : . ::::: ::: :.:: . : : .:... . . :.:.::: :.:: NP_060 IWKSLFQDIHPVPAALTLDPGTAHQRLILSDDCTIVAYGNLHPQPLQDSPKRFDVEVSVL 290 300 310 320 330 340 210 220 230 240 250 260 pF1KE3 GSRGFTSGKWYWEVEVAKKTKWTVGVVRESIIRKGSCPLTPEQGFWLLRLRNQTDLKALD ::..:.:: :::: ::.::.:..:...:. :::: . : .::. . ... .. .: NP_060 GSEAFSSGVHYWEVVVAEKTQWVIGLAHEAASRKGSIQIQPSRGFYCIVMHDGNQYSACT 350 360 370 380 390 400 270 280 290 300 310 320 pF1KE3 LPSFSLTLTNNLDKVGIYLDYEGGQLSFYNAKTMTHIYTFSNTFMEKLYPYFCPCLNDG- : :.. ..:::::..:::. : : :::: :. .::: . : :: :: : . . NP_060 EPWTRLNVRDKLDKVGVFLDYDQGLLIFYNADDMSWLYTFREKFPGKLCSYFSPGQSHAN 410 420 430 440 450 460 330 340 pF1KE3 GENKEPLHILHPQ :.: .::.: NP_060 GKNVQPLRINTVRI 470 >>XP_016857118 (OMIM: 616755) PREDICTED: E3 ubiquitin-pr (555 aa) initn: 524 init1: 368 opt: 635 Z-score: 573.9 bits: 115.3 E(85289): 3.1e-25 Smith-Waterman score: 635; 33.0% identity (63.4% similar) in 339 aa overlap (1-337:215-550) 10 20 30 pF1KE3 MEEELAIQQGQLETTLKELQTLRNMQKEAI ...:: : :. . .: .. :. . XP_016 TDRALLCFFCDEPALHEQHQVTGIDDAFDELQRELKDQLQALQDSEREHTEALQLLKRQL 190 200 210 220 230 240 40 50 60 70 80 90 pF1KE3 AAHKENKLHLQQHVSMEFLKLHQFLHSKEKDILTELREEGKALNEEMELNLSQLQEQCLL : : . :. .. : .::..:. ..: .: ::. . ..: .... ..: XP_016 AETKSSTKSLRTTIGEAFERLHRLLRERQKAMLEELEADTARTLTDIEQKVQRYSQQLRK 250 260 270 280 290 300 100 110 120 130 140 150 pF1KE3 AKDMLVSIQAKTEQQNSFDFLKDITTLLHSLEQGMKVLATRELISRKLNLGQYKGPIQYM ... .: . . . :: ...: . : .: :. : .: . . ..: ::.:: XP_016 VQEGAQILQERLAETDRHTFLAGVASLSERL-KG-KIHET-NLTYEDFPTSKYTGPLQYT 310 320 330 340 350 360 160 170 180 190 200 pF1KE3 VWREMQDTLCPGLSPLTLDPKTAHPNLVLSKSQTSVWHGDIK-KIMPDDPERFDSSVAVL .:. . . . : . ::::: ::: :.:: . : : .:... . . :.:.::: :.:: XP_016 IWKSLFQDIHPVPAALTLDPGTAHQRLILSDDCTIVAYGNLHPQPLQDSPKRFDVEVSVL 370 380 390 400 410 420 210 220 230 240 250 260 pF1KE3 GSRGFTSGKWYWEVEVAKKTKWTVGVVRESIIRKGSCPLTPEQGFWLLRLRNQTDLKALD ::..:.:: :::: ::.::.:..:...:. :::: . : .::. . ... .. .: XP_016 GSEAFSSGVHYWEVVVAEKTQWVIGLAHEAASRKGSIQIQPSRGFYCIVMHDGNQYSACT 430 440 450 460 470 480 270 280 290 300 310 320 pF1KE3 LPSFSLTLTNNLDKVGIYLDYEGGQLSFYNAKTMTHIYTFSNTFMEKLYPYFCPCLNDG- : :.. ..:::::..:::. : : :::: :. .::: . : :: :: : . . XP_016 EPWTRLNVRDKLDKVGVFLDYDQGLLIFYNADDMSWLYTFREKFPGKLCSYFSPGQSHAN 490 500 510 520 530 540 330 340 pF1KE3 GENKEPLHILHPQ :.: .::.: XP_016 GKNVQPLRINTVRI 550 >>NP_001317412 (OMIM: 616755) E3 ubiquitin-protein ligas (354 aa) initn: 571 init1: 368 opt: 630 Z-score: 572.6 bits: 114.4 E(85289): 3.7e-25 Smith-Waterman score: 630; 33.3% identity (63.1% similar) in 336 aa overlap (4-337:17-349) 10 20 30 40 pF1KE3 MEEELAIQQGQLETTLKELQTLRNMQKEAIAAHKENKLHLQQHVSME :: : :. . .: .. :. .: : . :. .. NP_001 MPEKTAVDQPWTQALRELKDQLQALQDSEREHTEALQLLKRQLAETKSSTKSLRTTIGEA 10 20 30 40 50 60 50 60 70 80 90 100 pF1KE3 FLKLHQFLHSKEKDILTELREEGKALNEEMELNLSQLQEQCLLAKDMLVSIQAKTEQQNS : .::..:. ..: .: ::. . ..: .... ..: ... .: . . . NP_001 FERLHRLLRERQKAMLEELEADTARTLTDIEQKVQRYSQQLRKVQEGAQILQERLAETDR 70 80 90 100 110 120 110 120 130 140 150 160 pF1KE3 FDFLKDITTLLHSLEQGMKVLATRELISRKLNLGQYKGPIQYMVWREMQDTLCPGLSPLT :: ...: . : .: :. : .: . . ..: ::.:: .:. . . . : . :: NP_001 HTFLAGVASLSERL-KG-KIHET-NLTYEDFPTSKYTGPLQYTIWKSLFQDIHPVPAALT 130 140 150 160 170 170 180 190 200 210 220 pF1KE3 LDPKTAHPNLVLSKSQTSVWHGDIK-KIMPDDPERFDSSVAVLGSRGFTSGKWYWEVEVA ::: ::: :.:: . : : .:... . . :.:.::: :.::::..:.:: :::: :: NP_001 LDPGTAHQRLILSDDCTIVAYGNLHPQPLQDSPKRFDVEVSVLGSEAFSSGVHYWEVVVA 180 190 200 210 220 230 230 240 250 260 270 280 pF1KE3 KKTKWTVGVVRESIIRKGSCPLTPEQGFWLLRLRNQTDLKALDLPSFSLTLTNNLDKVGI .::.:..:...:. :::: . : .::. . ... .. .: : :.. ..:::::. NP_001 EKTQWVIGLAHEAASRKGSIQIQPSRGFYCIVMHDGNQYSACTEPWTRLNVRDKLDKVGV 240 250 260 270 280 290 290 300 310 320 330 340 pF1KE3 YLDYEGGQLSFYNAKTMTHIYTFSNTFMEKLYPYFCPCLNDG-GENKEPLHILHPQ .:::. : : :::: :. .::: . : :: :: : . . :.: .::.: NP_001 FLDYDQGLLIFYNADDMSWLYTFREKFPGKLCSYFSPGQSHANGKNVQPLRINTVRI 300 310 320 330 340 350 >>XP_016857119 (OMIM: 616755) PREDICTED: E3 ubiquitin-pr (544 aa) initn: 546 init1: 368 opt: 607 Z-score: 549.3 bits: 110.7 E(85289): 7.4e-24 Smith-Waterman score: 607; 34.7% identity (65.3% similar) in 300 aa overlap (40-337:243-539) 10 20 30 40 50 60 pF1KE3 GQLETTLKELQTLRNMQKEAIAAHKENKLHLQQHVSMEFLKLHQFLHSKEKDILTELREE :. .. : .::..:. ..: .: ::. . XP_016 HRSAAAAQATTGGDQAITPDDCPPQSSTKSLRTTIGEAFERLHRLLRERQKAMLEELEAD 220 230 240 250 260 270 70 80 90 100 110 120 pF1KE3 GKALNEEMELNLSQLQEQCLLAKDMLVSIQAKTEQQNSFDFLKDITTLLHSLEQGMKVLA ..: .... ..: ... .: . . . :: ...: . : .: :. XP_016 TARTLTDIEQKVQRYSQQLRKVQEGAQILQERLAETDRHTFLAGVASLSERL-KG-KIHE 280 290 300 310 320 330 130 140 150 160 170 180 pF1KE3 TRELISRKLNLGQYKGPIQYMVWREMQDTLCPGLSPLTLDPKTAHPNLVLSKSQTSVWHG : .: . . ..: ::.:: .:. . . . : . ::::: ::: :.:: . : : .: XP_016 T-NLTYEDFPTSKYTGPLQYTIWKSLFQDIHPVPAALTLDPGTAHQRLILSDDCTIVAYG 340 350 360 370 380 190 200 210 220 230 240 pF1KE3 DIK-KIMPDDPERFDSSVAVLGSRGFTSGKWYWEVEVAKKTKWTVGVVRESIIRKGSCPL ... . . :.:.::: :.::::..:.:: :::: ::.::.:..:...:. :::: . XP_016 NLHPQPLQDSPKRFDVEVSVLGSEAFSSGVHYWEVVVAEKTQWVIGLAHEAASRKGSIQI 390 400 410 420 430 440 250 260 270 280 290 300 pF1KE3 TPEQGFWLLRLRNQTDLKALDLPSFSLTLTNNLDKVGIYLDYEGGQLSFYNAKTMTHIYT : .::. . ... .. .: : :.. ..:::::..:::. : : :::: :. .:: XP_016 QPSRGFYCIVMHDGNQYSACTEPWTRLNVRDKLDKVGVFLDYDQGLLIFYNADDMSWLYT 450 460 470 480 490 500 310 320 330 340 pF1KE3 FSNTFMEKLYPYFCPCLNDG-GENKEPLHILHPQ : . : :: :: : . . :.: .::.: XP_016 FREKFPGKLCSYFSPGQSHANGKNVQPLRINTVRI 510 520 530 540 341 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 08:35:21 2016 done: Sun Nov 6 08:35:22 2016 Total Scan time: 7.170 Total Display time: 0.020 Function used was FASTA [36.3.4 Apr, 2011]