Result of FASTA (omim) for
pFN21AE1797
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE1797, 843 aa
1>>>pF1KE1797 843 - 843 aa - 843 aa
Library: /omim/omim.rfq.tfa
64092750 residues in 91774 sequences
Statistics: Expectation_n fit: rho(ln(x))= 8.5439+/-0.000297; mu= 6.3237+/- 0.019
mean_var=163.4471+/-33.783, 0's: 0 Z-trim(121.6): 158 B-trim: 0 in 0/54
Lambda= 0.100320
statistics sampled from 39706 (39892) to 39706 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.764), E-opt: 0.2 (0.435), width: 16
Scan time: 6.970
The best scores are: opt bits E(91774)
XP_011523621 (OMIM: 114500,604025,608615) axin-2 i ( 843) 5752 844.7 0
XP_011523622 (OMIM: 114500,604025,608615) axin-2 i ( 843) 5752 844.7 0
XP_016880681 (OMIM: 114500,604025,608615) axin-2 i ( 843) 5752 844.7 0
XP_011523623 (OMIM: 114500,604025,608615) axin-2 i ( 843) 5752 844.7 0
NP_004646 (OMIM: 114500,604025,608615) axin-2 isof ( 843) 5752 844.7 0
XP_016880682 (OMIM: 114500,604025,608615) axin-2 i ( 778) 3885 574.5 6.9e-163
NP_001350742 (OMIM: 114500,604025,608615) axin-2 i ( 778) 3885 574.5 6.9e-163
NP_003493 (OMIM: 114550,603816,607864) axin-1 isof ( 862) 1441 220.8 2.3e-56
XP_011520986 (OMIM: 114550,603816,607864) axin-1 i ( 867) 1072 167.4 2.7e-40
XP_011520984 (OMIM: 114550,603816,607864) axin-1 i ( 916) 1072 167.4 2.9e-40
XP_011520988 (OMIM: 114550,603816,607864) axin-1 i ( 581) 1052 164.4 1.4e-39
XP_016879237 (OMIM: 114550,603816,607864) axin-1 i ( 478) 846 134.6 1.2e-30
XP_016879236 (OMIM: 114550,603816,607864) axin-1 i ( 479) 846 134.6 1.2e-30
XP_016879235 (OMIM: 114550,603816,607864) axin-1 i ( 512) 810 129.4 4.5e-29
XP_016879234 (OMIM: 114550,603816,607864) axin-1 i ( 582) 763 122.6 5.7e-27
NP_851393 (OMIM: 114550,603816,607864) axin-1 isof ( 826) 417 72.6 9.1e-12
XP_011520985 (OMIM: 114550,603816,607864) axin-1 i ( 880) 417 72.6 9.6e-12
NP_570138 (OMIM: 607192) regulator of G-protein si ( 235) 280 52.5 2.9e-06
NP_602299 (OMIM: 602189) regulator of G-protein si ( 168) 251 48.2 4e-05
NP_001263191 (OMIM: 602189) regulator of G-protein ( 168) 251 48.2 4e-05
NP_652760 (OMIM: 602189) regulator of G-protein si ( 311) 251 48.3 6.7e-05
NP_001263189 (OMIM: 602189) regulator of G-protein ( 519) 251 48.5 0.0001
NP_001338455 (OMIM: 602189) regulator of G-protein ( 519) 251 48.5 0.0001
NP_001269851 (OMIM: 602189) regulator of G-protein ( 519) 251 48.5 0.0001
NP_001309144 (OMIM: 602189) regulator of G-protein ( 537) 251 48.5 0.00011
NP_001263190 (OMIM: 602189) regulator of G-protein ( 591) 251 48.5 0.00012
NP_570613 (OMIM: 602189) regulator of G-protein si ( 917) 251 48.6 0.00017
NP_001269852 (OMIM: 602189) regulator of G-protein (1088) 251 48.6 0.0002
NP_652759 (OMIM: 602189) regulator of G-protein si (1198) 251 48.6 0.00021
NP_001005339 (OMIM: 602856) regulator of G-protein ( 181) 232 45.5 0.00028
NP_002916 (OMIM: 602856) regulator of G-protein si ( 167) 231 45.3 0.00029
NP_001034241 (OMIM: 612407) regulator of G-protein ( 152) 229 45.0 0.00033
NP_002913 (OMIM: 600323) regulator of G-protein si ( 209) 229 45.1 0.00043
NP_002914 (OMIM: 600861) regulator of G-protein si ( 211) 228 44.9 0.00048
XP_011508393 (OMIM: 607189) regulator of G-protein ( 178) 222 44.0 0.00076
NP_001356493 (OMIM: 607189) regulator of G-protein ( 180) 222 44.0 0.00077
XP_005245612 (OMIM: 607189) regulator of G-protein ( 180) 222 44.0 0.00077
XP_011508392 (OMIM: 607189) regulator of G-protein ( 180) 222 44.0 0.00077
XP_016858126 (OMIM: 607189) regulator of G-protein ( 180) 222 44.0 0.00077
NP_001095920 (OMIM: 607189) regulator of G-protein ( 180) 222 44.0 0.00077
XP_016858124 (OMIM: 607189) regulator of G-protein ( 180) 222 44.0 0.00077
XP_016858123 (OMIM: 607189) regulator of G-protein ( 198) 222 44.1 0.00084
XP_016858120 (OMIM: 607189) regulator of G-protein ( 198) 222 44.1 0.00084
XP_011508391 (OMIM: 607189) regulator of G-protein ( 198) 222 44.1 0.00084
XP_016858122 (OMIM: 607189) regulator of G-protein ( 198) 222 44.1 0.00084
XP_016858121 (OMIM: 607189) regulator of G-protein ( 198) 222 44.1 0.00084
NP_203131 (OMIM: 607189) regulator of G-protein si ( 198) 222 44.1 0.00084
XP_011508193 (OMIM: 607192) regulator of G-protein ( 144) 216 43.1 0.0012
NP_001241678 (OMIM: 145500,603276) regulator of G- ( 185) 206 41.7 0.0039
NP_003608 (OMIM: 145500,603276) regulator of G-pro ( 181) 205 41.6 0.0043
>>XP_011523621 (OMIM: 114500,604025,608615) axin-2 isofo (843 aa)
initn: 5752 init1: 5752 opt: 5752 Z-score: 4505.7 bits: 844.7 E(91774): 0
Smith-Waterman score: 5752; 99.9% identity (99.9% similar) in 843 aa overlap (1-843:1-843)
10 20 30 40 50 60
pF1KE1 MSSAMLVTCLPDPSSSFREDAPRPPVPGEEGETPPCQPGVGKGQVTKPMSVSSNTRRNED
::::::::::::::::::::::::::::::::::::::::::::::::: ::::::::::
XP_011 MSSAMLVTCLPDPSSSFREDAPRPPVPGEEGETPPCQPGVGKGQVTKPMPVSSNTRRNED
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 GLGEPEGRASPDSPLTRWTKSLHSLLGDQDGAYLFRTFLEREKCVDTLDFWFACNGFRQM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GLGEPEGRASPDSPLTRWTKSLHSLLGDQDGAYLFRTFLEREKCVDTLDFWFACNGFRQM
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 NLKDTKTLRVAKAIYKRYIENNSIVSKQLKPATKTYIRDGIKKQQIDSIMFDQAQTEIQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NLKDTKTLRVAKAIYKRYIENNSIVSKQLKPATKTYIRDGIKKQQIDSIMFDQAQTEIQS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE1 VMEENAYQMFLTSDIYLEYVRSGGENTAYMSNGGLGSLKVVCGYLPTLNEEEEWTCADFK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VMEENAYQMFLTSDIYLEYVRSGGENTAYMSNGGLGSLKVVCGYLPTLNEEEEWTCADFK
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE1 CKLSPTVVGLSSKTLRATASVRSTETVDSGYRSFKRSDPVNPYHIGSGYVFAPATSANDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CKLSPTVVGLSSKTLRATASVRSTETVDSGYRSFKRSDPVNPYHIGSGYVFAPATSANDS
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE1 EISSDALTDDSMSMTDSSVDGIPPYRVGSKKQLQREMHRSVKANGQVSLPHFPRTHRLPK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EISSDALTDDSMSMTDSSVDGIPPYRVGSKKQLQREMHRSVKANGQVSLPHFPRTHRLPK
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE1 EMTPVEPATFAAELISRLEKLKLELESRHSLEERLQQIREDEEREGSELTLNSREGAPTQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EMTPVEPATFAAELISRLEKLKLELESRHSLEERLQQIREDEEREGSELTLNSREGAPTQ
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE1 HPLSLLPSGSYEEDPQTILDDHLSRVLKTPGCQSPGVGRYSPRSRSPDHHHHHHSQYHSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HPLSLLPSGSYEEDPQTILDDHLSRVLKTPGCQSPGVGRYSPRSRSPDHHHHHHSQYHSL
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE1 LPPGGKLPPAAASPGACPLLGGKGFVTKQTTKHVHHHYIHHHAVPKTKEEIEAEATQRVH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LPPGGKLPPAAASPGACPLLGGKGFVTKQTTKHVHHHYIHHHAVPKTKEEIEAEATQRVH
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE1 CFCPGGSEYYCYSKCKSHSKAPETMPSEQFGGSRGSTLPKRNGKGTEPGLALPAREGGAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CFCPGGSEYYCYSKCKSHSKAPETMPSEQFGGSRGSTLPKRNGKGTEPGLALPAREGGAP
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE1 GGAGALQLPREEGDRSQDVWQWMLESERQSKPKPHSAQSTKKAYPLESARSSPGERASRH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GGAGALQLPREEGDRSQDVWQWMLESERQSKPKPHSAQSTKKAYPLESARSSPGERASRH
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE1 HLWGGNSGHPRTTPRAHLFTQDPAMPPLTPPNTLAQLEEACRRLAEVSKPPKQRCCVASQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HLWGGNSGHPRTTPRAHLFTQDPAMPPLTPPNTLAQLEEACRRLAEVSKPPKQRCCVASQ
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE1 QRDRNHSATVQTGATPFSNPSLAPEDHKEPKKLAGVHALQASELVVTYFFCGEEIPYRRM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QRDRNHSATVQTGATPFSNPSLAPEDHKEPKKLAGVHALQASELVVTYFFCGEEIPYRRM
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE1 LKAQSLTLGHFKEQLSKKGNYRYYFKKASDEFACGAVFEEIWEDETVLPMYEGRILGKVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LKAQSLTLGHFKEQLSKKGNYRYYFKKASDEFACGAVFEEIWEDETVLPMYEGRILGKVE
790 800 810 820 830 840
pF1KE1 RID
:::
XP_011 RID
>>XP_011523622 (OMIM: 114500,604025,608615) axin-2 isofo (843 aa)
initn: 5752 init1: 5752 opt: 5752 Z-score: 4505.7 bits: 844.7 E(91774): 0
Smith-Waterman score: 5752; 99.9% identity (99.9% similar) in 843 aa overlap (1-843:1-843)
10 20 30 40 50 60
pF1KE1 MSSAMLVTCLPDPSSSFREDAPRPPVPGEEGETPPCQPGVGKGQVTKPMSVSSNTRRNED
::::::::::::::::::::::::::::::::::::::::::::::::: ::::::::::
XP_011 MSSAMLVTCLPDPSSSFREDAPRPPVPGEEGETPPCQPGVGKGQVTKPMPVSSNTRRNED
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 GLGEPEGRASPDSPLTRWTKSLHSLLGDQDGAYLFRTFLEREKCVDTLDFWFACNGFRQM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GLGEPEGRASPDSPLTRWTKSLHSLLGDQDGAYLFRTFLEREKCVDTLDFWFACNGFRQM
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 NLKDTKTLRVAKAIYKRYIENNSIVSKQLKPATKTYIRDGIKKQQIDSIMFDQAQTEIQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NLKDTKTLRVAKAIYKRYIENNSIVSKQLKPATKTYIRDGIKKQQIDSIMFDQAQTEIQS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE1 VMEENAYQMFLTSDIYLEYVRSGGENTAYMSNGGLGSLKVVCGYLPTLNEEEEWTCADFK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VMEENAYQMFLTSDIYLEYVRSGGENTAYMSNGGLGSLKVVCGYLPTLNEEEEWTCADFK
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE1 CKLSPTVVGLSSKTLRATASVRSTETVDSGYRSFKRSDPVNPYHIGSGYVFAPATSANDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CKLSPTVVGLSSKTLRATASVRSTETVDSGYRSFKRSDPVNPYHIGSGYVFAPATSANDS
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE1 EISSDALTDDSMSMTDSSVDGIPPYRVGSKKQLQREMHRSVKANGQVSLPHFPRTHRLPK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EISSDALTDDSMSMTDSSVDGIPPYRVGSKKQLQREMHRSVKANGQVSLPHFPRTHRLPK
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE1 EMTPVEPATFAAELISRLEKLKLELESRHSLEERLQQIREDEEREGSELTLNSREGAPTQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EMTPVEPATFAAELISRLEKLKLELESRHSLEERLQQIREDEEREGSELTLNSREGAPTQ
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE1 HPLSLLPSGSYEEDPQTILDDHLSRVLKTPGCQSPGVGRYSPRSRSPDHHHHHHSQYHSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HPLSLLPSGSYEEDPQTILDDHLSRVLKTPGCQSPGVGRYSPRSRSPDHHHHHHSQYHSL
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE1 LPPGGKLPPAAASPGACPLLGGKGFVTKQTTKHVHHHYIHHHAVPKTKEEIEAEATQRVH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LPPGGKLPPAAASPGACPLLGGKGFVTKQTTKHVHHHYIHHHAVPKTKEEIEAEATQRVH
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE1 CFCPGGSEYYCYSKCKSHSKAPETMPSEQFGGSRGSTLPKRNGKGTEPGLALPAREGGAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CFCPGGSEYYCYSKCKSHSKAPETMPSEQFGGSRGSTLPKRNGKGTEPGLALPAREGGAP
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE1 GGAGALQLPREEGDRSQDVWQWMLESERQSKPKPHSAQSTKKAYPLESARSSPGERASRH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GGAGALQLPREEGDRSQDVWQWMLESERQSKPKPHSAQSTKKAYPLESARSSPGERASRH
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE1 HLWGGNSGHPRTTPRAHLFTQDPAMPPLTPPNTLAQLEEACRRLAEVSKPPKQRCCVASQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HLWGGNSGHPRTTPRAHLFTQDPAMPPLTPPNTLAQLEEACRRLAEVSKPPKQRCCVASQ
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE1 QRDRNHSATVQTGATPFSNPSLAPEDHKEPKKLAGVHALQASELVVTYFFCGEEIPYRRM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QRDRNHSATVQTGATPFSNPSLAPEDHKEPKKLAGVHALQASELVVTYFFCGEEIPYRRM
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE1 LKAQSLTLGHFKEQLSKKGNYRYYFKKASDEFACGAVFEEIWEDETVLPMYEGRILGKVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LKAQSLTLGHFKEQLSKKGNYRYYFKKASDEFACGAVFEEIWEDETVLPMYEGRILGKVE
790 800 810 820 830 840
pF1KE1 RID
:::
XP_011 RID
>>XP_016880681 (OMIM: 114500,604025,608615) axin-2 isofo (843 aa)
initn: 5752 init1: 5752 opt: 5752 Z-score: 4505.7 bits: 844.7 E(91774): 0
Smith-Waterman score: 5752; 99.9% identity (99.9% similar) in 843 aa overlap (1-843:1-843)
10 20 30 40 50 60
pF1KE1 MSSAMLVTCLPDPSSSFREDAPRPPVPGEEGETPPCQPGVGKGQVTKPMSVSSNTRRNED
::::::::::::::::::::::::::::::::::::::::::::::::: ::::::::::
XP_016 MSSAMLVTCLPDPSSSFREDAPRPPVPGEEGETPPCQPGVGKGQVTKPMPVSSNTRRNED
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 GLGEPEGRASPDSPLTRWTKSLHSLLGDQDGAYLFRTFLEREKCVDTLDFWFACNGFRQM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GLGEPEGRASPDSPLTRWTKSLHSLLGDQDGAYLFRTFLEREKCVDTLDFWFACNGFRQM
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 NLKDTKTLRVAKAIYKRYIENNSIVSKQLKPATKTYIRDGIKKQQIDSIMFDQAQTEIQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NLKDTKTLRVAKAIYKRYIENNSIVSKQLKPATKTYIRDGIKKQQIDSIMFDQAQTEIQS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE1 VMEENAYQMFLTSDIYLEYVRSGGENTAYMSNGGLGSLKVVCGYLPTLNEEEEWTCADFK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VMEENAYQMFLTSDIYLEYVRSGGENTAYMSNGGLGSLKVVCGYLPTLNEEEEWTCADFK
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE1 CKLSPTVVGLSSKTLRATASVRSTETVDSGYRSFKRSDPVNPYHIGSGYVFAPATSANDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CKLSPTVVGLSSKTLRATASVRSTETVDSGYRSFKRSDPVNPYHIGSGYVFAPATSANDS
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE1 EISSDALTDDSMSMTDSSVDGIPPYRVGSKKQLQREMHRSVKANGQVSLPHFPRTHRLPK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EISSDALTDDSMSMTDSSVDGIPPYRVGSKKQLQREMHRSVKANGQVSLPHFPRTHRLPK
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE1 EMTPVEPATFAAELISRLEKLKLELESRHSLEERLQQIREDEEREGSELTLNSREGAPTQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EMTPVEPATFAAELISRLEKLKLELESRHSLEERLQQIREDEEREGSELTLNSREGAPTQ
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE1 HPLSLLPSGSYEEDPQTILDDHLSRVLKTPGCQSPGVGRYSPRSRSPDHHHHHHSQYHSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HPLSLLPSGSYEEDPQTILDDHLSRVLKTPGCQSPGVGRYSPRSRSPDHHHHHHSQYHSL
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE1 LPPGGKLPPAAASPGACPLLGGKGFVTKQTTKHVHHHYIHHHAVPKTKEEIEAEATQRVH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LPPGGKLPPAAASPGACPLLGGKGFVTKQTTKHVHHHYIHHHAVPKTKEEIEAEATQRVH
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE1 CFCPGGSEYYCYSKCKSHSKAPETMPSEQFGGSRGSTLPKRNGKGTEPGLALPAREGGAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CFCPGGSEYYCYSKCKSHSKAPETMPSEQFGGSRGSTLPKRNGKGTEPGLALPAREGGAP
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE1 GGAGALQLPREEGDRSQDVWQWMLESERQSKPKPHSAQSTKKAYPLESARSSPGERASRH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GGAGALQLPREEGDRSQDVWQWMLESERQSKPKPHSAQSTKKAYPLESARSSPGERASRH
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE1 HLWGGNSGHPRTTPRAHLFTQDPAMPPLTPPNTLAQLEEACRRLAEVSKPPKQRCCVASQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HLWGGNSGHPRTTPRAHLFTQDPAMPPLTPPNTLAQLEEACRRLAEVSKPPKQRCCVASQ
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE1 QRDRNHSATVQTGATPFSNPSLAPEDHKEPKKLAGVHALQASELVVTYFFCGEEIPYRRM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QRDRNHSATVQTGATPFSNPSLAPEDHKEPKKLAGVHALQASELVVTYFFCGEEIPYRRM
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE1 LKAQSLTLGHFKEQLSKKGNYRYYFKKASDEFACGAVFEEIWEDETVLPMYEGRILGKVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LKAQSLTLGHFKEQLSKKGNYRYYFKKASDEFACGAVFEEIWEDETVLPMYEGRILGKVE
790 800 810 820 830 840
pF1KE1 RID
:::
XP_016 RID
>>XP_011523623 (OMIM: 114500,604025,608615) axin-2 isofo (843 aa)
initn: 5752 init1: 5752 opt: 5752 Z-score: 4505.7 bits: 844.7 E(91774): 0
Smith-Waterman score: 5752; 99.9% identity (99.9% similar) in 843 aa overlap (1-843:1-843)
10 20 30 40 50 60
pF1KE1 MSSAMLVTCLPDPSSSFREDAPRPPVPGEEGETPPCQPGVGKGQVTKPMSVSSNTRRNED
::::::::::::::::::::::::::::::::::::::::::::::::: ::::::::::
XP_011 MSSAMLVTCLPDPSSSFREDAPRPPVPGEEGETPPCQPGVGKGQVTKPMPVSSNTRRNED
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 GLGEPEGRASPDSPLTRWTKSLHSLLGDQDGAYLFRTFLEREKCVDTLDFWFACNGFRQM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GLGEPEGRASPDSPLTRWTKSLHSLLGDQDGAYLFRTFLEREKCVDTLDFWFACNGFRQM
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 NLKDTKTLRVAKAIYKRYIENNSIVSKQLKPATKTYIRDGIKKQQIDSIMFDQAQTEIQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NLKDTKTLRVAKAIYKRYIENNSIVSKQLKPATKTYIRDGIKKQQIDSIMFDQAQTEIQS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE1 VMEENAYQMFLTSDIYLEYVRSGGENTAYMSNGGLGSLKVVCGYLPTLNEEEEWTCADFK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VMEENAYQMFLTSDIYLEYVRSGGENTAYMSNGGLGSLKVVCGYLPTLNEEEEWTCADFK
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE1 CKLSPTVVGLSSKTLRATASVRSTETVDSGYRSFKRSDPVNPYHIGSGYVFAPATSANDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CKLSPTVVGLSSKTLRATASVRSTETVDSGYRSFKRSDPVNPYHIGSGYVFAPATSANDS
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE1 EISSDALTDDSMSMTDSSVDGIPPYRVGSKKQLQREMHRSVKANGQVSLPHFPRTHRLPK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EISSDALTDDSMSMTDSSVDGIPPYRVGSKKQLQREMHRSVKANGQVSLPHFPRTHRLPK
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE1 EMTPVEPATFAAELISRLEKLKLELESRHSLEERLQQIREDEEREGSELTLNSREGAPTQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EMTPVEPATFAAELISRLEKLKLELESRHSLEERLQQIREDEEREGSELTLNSREGAPTQ
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE1 HPLSLLPSGSYEEDPQTILDDHLSRVLKTPGCQSPGVGRYSPRSRSPDHHHHHHSQYHSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HPLSLLPSGSYEEDPQTILDDHLSRVLKTPGCQSPGVGRYSPRSRSPDHHHHHHSQYHSL
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE1 LPPGGKLPPAAASPGACPLLGGKGFVTKQTTKHVHHHYIHHHAVPKTKEEIEAEATQRVH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LPPGGKLPPAAASPGACPLLGGKGFVTKQTTKHVHHHYIHHHAVPKTKEEIEAEATQRVH
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE1 CFCPGGSEYYCYSKCKSHSKAPETMPSEQFGGSRGSTLPKRNGKGTEPGLALPAREGGAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CFCPGGSEYYCYSKCKSHSKAPETMPSEQFGGSRGSTLPKRNGKGTEPGLALPAREGGAP
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE1 GGAGALQLPREEGDRSQDVWQWMLESERQSKPKPHSAQSTKKAYPLESARSSPGERASRH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GGAGALQLPREEGDRSQDVWQWMLESERQSKPKPHSAQSTKKAYPLESARSSPGERASRH
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE1 HLWGGNSGHPRTTPRAHLFTQDPAMPPLTPPNTLAQLEEACRRLAEVSKPPKQRCCVASQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HLWGGNSGHPRTTPRAHLFTQDPAMPPLTPPNTLAQLEEACRRLAEVSKPPKQRCCVASQ
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE1 QRDRNHSATVQTGATPFSNPSLAPEDHKEPKKLAGVHALQASELVVTYFFCGEEIPYRRM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QRDRNHSATVQTGATPFSNPSLAPEDHKEPKKLAGVHALQASELVVTYFFCGEEIPYRRM
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE1 LKAQSLTLGHFKEQLSKKGNYRYYFKKASDEFACGAVFEEIWEDETVLPMYEGRILGKVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LKAQSLTLGHFKEQLSKKGNYRYYFKKASDEFACGAVFEEIWEDETVLPMYEGRILGKVE
790 800 810 820 830 840
pF1KE1 RID
:::
XP_011 RID
>>NP_004646 (OMIM: 114500,604025,608615) axin-2 isoform (843 aa)
initn: 5752 init1: 5752 opt: 5752 Z-score: 4505.7 bits: 844.7 E(91774): 0
Smith-Waterman score: 5752; 99.9% identity (99.9% similar) in 843 aa overlap (1-843:1-843)
10 20 30 40 50 60
pF1KE1 MSSAMLVTCLPDPSSSFREDAPRPPVPGEEGETPPCQPGVGKGQVTKPMSVSSNTRRNED
::::::::::::::::::::::::::::::::::::::::::::::::: ::::::::::
NP_004 MSSAMLVTCLPDPSSSFREDAPRPPVPGEEGETPPCQPGVGKGQVTKPMPVSSNTRRNED
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 GLGEPEGRASPDSPLTRWTKSLHSLLGDQDGAYLFRTFLEREKCVDTLDFWFACNGFRQM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 GLGEPEGRASPDSPLTRWTKSLHSLLGDQDGAYLFRTFLEREKCVDTLDFWFACNGFRQM
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 NLKDTKTLRVAKAIYKRYIENNSIVSKQLKPATKTYIRDGIKKQQIDSIMFDQAQTEIQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 NLKDTKTLRVAKAIYKRYIENNSIVSKQLKPATKTYIRDGIKKQQIDSIMFDQAQTEIQS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE1 VMEENAYQMFLTSDIYLEYVRSGGENTAYMSNGGLGSLKVVCGYLPTLNEEEEWTCADFK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 VMEENAYQMFLTSDIYLEYVRSGGENTAYMSNGGLGSLKVVCGYLPTLNEEEEWTCADFK
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE1 CKLSPTVVGLSSKTLRATASVRSTETVDSGYRSFKRSDPVNPYHIGSGYVFAPATSANDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 CKLSPTVVGLSSKTLRATASVRSTETVDSGYRSFKRSDPVNPYHIGSGYVFAPATSANDS
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE1 EISSDALTDDSMSMTDSSVDGIPPYRVGSKKQLQREMHRSVKANGQVSLPHFPRTHRLPK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 EISSDALTDDSMSMTDSSVDGIPPYRVGSKKQLQREMHRSVKANGQVSLPHFPRTHRLPK
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE1 EMTPVEPATFAAELISRLEKLKLELESRHSLEERLQQIREDEEREGSELTLNSREGAPTQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 EMTPVEPATFAAELISRLEKLKLELESRHSLEERLQQIREDEEREGSELTLNSREGAPTQ
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE1 HPLSLLPSGSYEEDPQTILDDHLSRVLKTPGCQSPGVGRYSPRSRSPDHHHHHHSQYHSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 HPLSLLPSGSYEEDPQTILDDHLSRVLKTPGCQSPGVGRYSPRSRSPDHHHHHHSQYHSL
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE1 LPPGGKLPPAAASPGACPLLGGKGFVTKQTTKHVHHHYIHHHAVPKTKEEIEAEATQRVH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 LPPGGKLPPAAASPGACPLLGGKGFVTKQTTKHVHHHYIHHHAVPKTKEEIEAEATQRVH
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE1 CFCPGGSEYYCYSKCKSHSKAPETMPSEQFGGSRGSTLPKRNGKGTEPGLALPAREGGAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 CFCPGGSEYYCYSKCKSHSKAPETMPSEQFGGSRGSTLPKRNGKGTEPGLALPAREGGAP
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE1 GGAGALQLPREEGDRSQDVWQWMLESERQSKPKPHSAQSTKKAYPLESARSSPGERASRH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 GGAGALQLPREEGDRSQDVWQWMLESERQSKPKPHSAQSTKKAYPLESARSSPGERASRH
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE1 HLWGGNSGHPRTTPRAHLFTQDPAMPPLTPPNTLAQLEEACRRLAEVSKPPKQRCCVASQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 HLWGGNSGHPRTTPRAHLFTQDPAMPPLTPPNTLAQLEEACRRLAEVSKPPKQRCCVASQ
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE1 QRDRNHSATVQTGATPFSNPSLAPEDHKEPKKLAGVHALQASELVVTYFFCGEEIPYRRM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 QRDRNHSATVQTGATPFSNPSLAPEDHKEPKKLAGVHALQASELVVTYFFCGEEIPYRRM
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE1 LKAQSLTLGHFKEQLSKKGNYRYYFKKASDEFACGAVFEEIWEDETVLPMYEGRILGKVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 LKAQSLTLGHFKEQLSKKGNYRYYFKKASDEFACGAVFEEIWEDETVLPMYEGRILGKVE
790 800 810 820 830 840
pF1KE1 RID
:::
NP_004 RID
>>XP_016880682 (OMIM: 114500,604025,608615) axin-2 isofo (778 aa)
initn: 3879 init1: 3879 opt: 3885 Z-score: 3045.9 bits: 574.5 E(91774): 6.9e-163
Smith-Waterman score: 5154; 92.2% identity (92.2% similar) in 843 aa overlap (1-843:1-778)
10 20 30 40 50 60
pF1KE1 MSSAMLVTCLPDPSSSFREDAPRPPVPGEEGETPPCQPGVGKGQVTKPMSVSSNTRRNED
::::::::::::::::::::::::::::::::::::::::::::::::: ::::::::::
XP_016 MSSAMLVTCLPDPSSSFREDAPRPPVPGEEGETPPCQPGVGKGQVTKPMPVSSNTRRNED
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 GLGEPEGRASPDSPLTRWTKSLHSLLGDQDGAYLFRTFLEREKCVDTLDFWFACNGFRQM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GLGEPEGRASPDSPLTRWTKSLHSLLGDQDGAYLFRTFLEREKCVDTLDFWFACNGFRQM
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 NLKDTKTLRVAKAIYKRYIENNSIVSKQLKPATKTYIRDGIKKQQIDSIMFDQAQTEIQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NLKDTKTLRVAKAIYKRYIENNSIVSKQLKPATKTYIRDGIKKQQIDSIMFDQAQTEIQS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE1 VMEENAYQMFLTSDIYLEYVRSGGENTAYMSNGGLGSLKVVCGYLPTLNEEEEWTCADFK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VMEENAYQMFLTSDIYLEYVRSGGENTAYMSNGGLGSLKVVCGYLPTLNEEEEWTCADFK
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE1 CKLSPTVVGLSSKTLRATASVRSTETVDSGYRSFKRSDPVNPYHIGSGYVFAPATSANDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CKLSPTVVGLSSKTLRATASVRSTETVDSGYRSFKRSDPVNPYHIGSGYVFAPATSANDS
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE1 EISSDALTDDSMSMTDSSVDGIPPYRVGSKKQLQREMHRSVKANGQVSLPHFPRTHRLPK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EISSDALTDDSMSMTDSSVDGIPPYRVGSKKQLQREMHRSVKANGQVSLPHFPRTHRLPK
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE1 EMTPVEPATFAAELISRLEKLKLELESRHSLEERLQQIREDEEREGSELTLNSREGAPTQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EMTPVEPATFAAELISRLEKLKLELESRHSLEERLQQIREDEEREGSELTLNSREGAPTQ
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE1 HPLSLLPSGSYEEDPQTILDDHLSRVLKTPGCQSPGVGRYSPRSRSPDHHHHHHSQYHSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HPLSLLPSGSYEEDPQTILDDHLSRVLKTPGCQSPGVGRYSPRSRSPDHHHHHHSQYHSL
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE1 LPPGGKLPPAAASPGACPLLGGKGFVTKQTTKHVHHHYIHHHAVPKTKEEIEAEATQRVH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LPPGGKLPPAAASPGACPLLGGKGFVTKQTTKHVHHHYIHHHAVPKTKEEIEAEATQRVH
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE1 CFCPGGSEYYCYSKCKSHSKAPETMPSEQFGGSRGSTLPKRNGKGTEPGLALPAREGGAP
:::::::::::::::::::::::::::::::
XP_016 CFCPGGSEYYCYSKCKSHSKAPETMPSEQFG-----------------------------
550 560 570
610 620 630 640 650 660
pF1KE1 GGAGALQLPREEGDRSQDVWQWMLESERQSKPKPHSAQSTKKAYPLESARSSPGERASRH
::::::::::::::::::::::::
XP_016 ------------------------------------AQSTKKAYPLESARSSPGERASRH
580 590
670 680 690 700 710 720
pF1KE1 HLWGGNSGHPRTTPRAHLFTQDPAMPPLTPPNTLAQLEEACRRLAEVSKPPKQRCCVASQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HLWGGNSGHPRTTPRAHLFTQDPAMPPLTPPNTLAQLEEACRRLAEVSKPPKQRCCVASQ
600 610 620 630 640 650
730 740 750 760 770 780
pF1KE1 QRDRNHSATVQTGATPFSNPSLAPEDHKEPKKLAGVHALQASELVVTYFFCGEEIPYRRM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QRDRNHSATVQTGATPFSNPSLAPEDHKEPKKLAGVHALQASELVVTYFFCGEEIPYRRM
660 670 680 690 700 710
790 800 810 820 830 840
pF1KE1 LKAQSLTLGHFKEQLSKKGNYRYYFKKASDEFACGAVFEEIWEDETVLPMYEGRILGKVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LKAQSLTLGHFKEQLSKKGNYRYYFKKASDEFACGAVFEEIWEDETVLPMYEGRILGKVE
720 730 740 750 760 770
pF1KE1 RID
:::
XP_016 RID
>>NP_001350742 (OMIM: 114500,604025,608615) axin-2 isofo (778 aa)
initn: 3879 init1: 3879 opt: 3885 Z-score: 3045.9 bits: 574.5 E(91774): 6.9e-163
Smith-Waterman score: 5154; 92.2% identity (92.2% similar) in 843 aa overlap (1-843:1-778)
10 20 30 40 50 60
pF1KE1 MSSAMLVTCLPDPSSSFREDAPRPPVPGEEGETPPCQPGVGKGQVTKPMSVSSNTRRNED
::::::::::::::::::::::::::::::::::::::::::::::::: ::::::::::
NP_001 MSSAMLVTCLPDPSSSFREDAPRPPVPGEEGETPPCQPGVGKGQVTKPMPVSSNTRRNED
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 GLGEPEGRASPDSPLTRWTKSLHSLLGDQDGAYLFRTFLEREKCVDTLDFWFACNGFRQM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GLGEPEGRASPDSPLTRWTKSLHSLLGDQDGAYLFRTFLEREKCVDTLDFWFACNGFRQM
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 NLKDTKTLRVAKAIYKRYIENNSIVSKQLKPATKTYIRDGIKKQQIDSIMFDQAQTEIQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NLKDTKTLRVAKAIYKRYIENNSIVSKQLKPATKTYIRDGIKKQQIDSIMFDQAQTEIQS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE1 VMEENAYQMFLTSDIYLEYVRSGGENTAYMSNGGLGSLKVVCGYLPTLNEEEEWTCADFK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VMEENAYQMFLTSDIYLEYVRSGGENTAYMSNGGLGSLKVVCGYLPTLNEEEEWTCADFK
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE1 CKLSPTVVGLSSKTLRATASVRSTETVDSGYRSFKRSDPVNPYHIGSGYVFAPATSANDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CKLSPTVVGLSSKTLRATASVRSTETVDSGYRSFKRSDPVNPYHIGSGYVFAPATSANDS
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE1 EISSDALTDDSMSMTDSSVDGIPPYRVGSKKQLQREMHRSVKANGQVSLPHFPRTHRLPK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EISSDALTDDSMSMTDSSVDGIPPYRVGSKKQLQREMHRSVKANGQVSLPHFPRTHRLPK
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE1 EMTPVEPATFAAELISRLEKLKLELESRHSLEERLQQIREDEEREGSELTLNSREGAPTQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EMTPVEPATFAAELISRLEKLKLELESRHSLEERLQQIREDEEREGSELTLNSREGAPTQ
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE1 HPLSLLPSGSYEEDPQTILDDHLSRVLKTPGCQSPGVGRYSPRSRSPDHHHHHHSQYHSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HPLSLLPSGSYEEDPQTILDDHLSRVLKTPGCQSPGVGRYSPRSRSPDHHHHHHSQYHSL
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE1 LPPGGKLPPAAASPGACPLLGGKGFVTKQTTKHVHHHYIHHHAVPKTKEEIEAEATQRVH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LPPGGKLPPAAASPGACPLLGGKGFVTKQTTKHVHHHYIHHHAVPKTKEEIEAEATQRVH
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE1 CFCPGGSEYYCYSKCKSHSKAPETMPSEQFGGSRGSTLPKRNGKGTEPGLALPAREGGAP
:::::::::::::::::::::::::::::::
NP_001 CFCPGGSEYYCYSKCKSHSKAPETMPSEQFG-----------------------------
550 560 570
610 620 630 640 650 660
pF1KE1 GGAGALQLPREEGDRSQDVWQWMLESERQSKPKPHSAQSTKKAYPLESARSSPGERASRH
::::::::::::::::::::::::
NP_001 ------------------------------------AQSTKKAYPLESARSSPGERASRH
580 590
670 680 690 700 710 720
pF1KE1 HLWGGNSGHPRTTPRAHLFTQDPAMPPLTPPNTLAQLEEACRRLAEVSKPPKQRCCVASQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HLWGGNSGHPRTTPRAHLFTQDPAMPPLTPPNTLAQLEEACRRLAEVSKPPKQRCCVASQ
600 610 620 630 640 650
730 740 750 760 770 780
pF1KE1 QRDRNHSATVQTGATPFSNPSLAPEDHKEPKKLAGVHALQASELVVTYFFCGEEIPYRRM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QRDRNHSATVQTGATPFSNPSLAPEDHKEPKKLAGVHALQASELVVTYFFCGEEIPYRRM
660 670 680 690 700 710
790 800 810 820 830 840
pF1KE1 LKAQSLTLGHFKEQLSKKGNYRYYFKKASDEFACGAVFEEIWEDETVLPMYEGRILGKVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LKAQSLTLGHFKEQLSKKGNYRYYFKKASDEFACGAVFEEIWEDETVLPMYEGRILGKVE
720 730 740 750 760 770
pF1KE1 RID
:::
NP_001 RID
>>NP_003493 (OMIM: 114550,603816,607864) axin-1 isoform (862 aa)
initn: 1578 init1: 404 opt: 1441 Z-score: 1133.5 bits: 220.8 E(91774): 2.3e-56
Smith-Waterman score: 2112; 43.4% identity (66.6% similar) in 892 aa overlap (12-843:11-862)
10 20 30 40 50
pF1KE1 MSSAMLVTCLPDPSSSFREDAPRPPVPGEEGETPPCQPG-------VGKGQVTKPMSVSS
: ..:: :::::::::::::: .: ::: : . ..
NP_003 MNIQEQGFPLDLGASFTEDAPRPPVPGEEGELVSTDPRPASYSFCSGKGVGIKGETSTA
10 20 30 40 50
60 70 80 90 100 110
pF1KE1 NTRRNEDGLG-EPEGRASPDSPLTRWTKSLHSLLGDQDGAYLFRTFLEREKCVDTLDFWF
. ::.. :: :::: ::: : .:..:::::: :::: ::::::..: :.: :::::
NP_003 TPRRSDLDLGYEPEGSASPTPPYLKWAESLHSLLDDQDGISLFRTFLKQEGCADLLDFWF
60 70 80 90 100 110
120 130 140 150 160
pF1KE1 ACNGFRQMNLKDT---KTLRVAKAIYKRYI-ENNSIVSKQLKPATKTYIRDGIKKQQIDS
::.:::... :. : :..:.:::..:: .::.:::.: :::::..:. : :: ::
NP_003 ACTGFRKLEPCDSNEEKRLKLARAIYRKYILDNNGIVSRQTKPATKSFIKGCIMKQLIDP
120 130 140 150 160 170
170 180 190 200 210 220
pF1KE1 IMFDQAQTEIQSVMEENAYQMFLTSDIYLEYVRSGGENTAYMSN--GGLGSLKVVCGYLP
::::::::::..::::.: :: :::::::.:.:.:. :. .: :. : . ::::
NP_003 AMFDQAQTEIQATMEENTYPSFLKSDIYLEYTRTGSESPKVCSDQSSGSGTGKGISGYLP
180 190 200 210 220 230
230 240 250 260 270
pF1KE1 TLNEEEEWTC-----------ADFKCKLSPTVVGLSSKTLRATASVRSTETVDSGYRSFK
::::.::: : : .: : . : . . :...: : .: . : :..
NP_003 TLNEDEEWKCDQDMDEDDGRDAAPPGRL-PQKLLLETAAPRVSSSRRYSEGREFRYGSWR
240 250 260 270 280 290
280 290 300 310 320 330
pF1KE1 RSDPVNPYHIGSGYVFAPATSANDSEISSDALTDDSMSMTDSSVDGIPPYRVGSKKQLQR
.:::::....::..:::::::::: .: . :..:.::::::::::::. .:: .:
NP_003 --EPVNPYYVNAGYALAPATSANDSEQQSLSSDADTLSLTDSSVDGIPPYRI--RKQHRR
300 310 320 330 340 350
340 350 360 370 380 390
pF1KE1 EMHRSVKANGQVSLPHFPRTHRLPKEMTPVEPATFAAELISRLEKLKLELESRHSLEERL
::..::..::.: :::.:::.:.:::. ::: :: ::: ::: .. :....:::::
NP_003 EMQESVQVNGRVPLPHIPRTYRVPKEVR-VEPQKFAEELIHRLEAVQRTREAEEKLEERL
360 370 380 390 400 410
400 410 420 430 440
pF1KE1 QQIREDEERE------GSELTLNSREGAPTQH--PLSLLPSG------SYEEDPQTILDD
...: .:: : : .. ::. : : . : ..::.:..:::.
NP_003 KRVRMEEEGEDGDPSSGPPGPCHKLPPAPAWHHFPPRCVDMGCAGLRDAHEENPESILDE
420 430 440 450 460 470
450 460 470 480 490 500
pF1KE1 HLSRVLKTPGCQSPGVGRYSPRSRSPDHHHHHHSQYHSLLPPGGKLPPAAASPGA-CPLL
:..:::.::: :::: : :::: : . .: . : ::.. : :
NP_003 HVQRVLRTPGRQSPG-----PGHRSPDSGHV------AKMPVA--LGGAASGHGKHVPKS
480 490 500 510 520
510 520 530 540 550
pF1KE1 GGK-GFVTKQTTKHVHHHYIHHHAVPKTKEEIEAEATQRVHCFCPGGSEYYCY-SKCKSH
:.: . . .::::: ::.. . ::..:::::.:.. : : . . .. ...
NP_003 GAKLDAAGLHHHRHVHHHV--HHSTARPKEQVEAEATRRAQSSFAWGLEPHSHGARSRGY
530 540 550 560 570
560 570 580 590 600 610
pF1KE1 SKAPETMPSEQFGGSRGSTLP---KRNGKGTEPGLALPAREGGAPGGAGALQLPREEGDR
:.. . :. . : .... . :::.: .: : . .. .::.. :....
NP_003 SESVGAAPNASDGLAHSGKVGVACKRNAKKAESGKSASTE---VPGAS-------EDAEK
580 590 600 610 620
620 630 640 650 660 670
pF1KE1 SQDVWQWMLESERQ-SKPK--PHSAQSTKKAYPLESARSSPGERASRHHLWGGNSGHPRT
.: . ::..:.:.. :. . :....:.: : :..: : : .: :.: . . .
NP_003 NQKIMQWIIEGEKEISRHRRTGHGSSGTRKPQPHENSR--P---LSLEHPWAGPQLRTSV
630 640 650 660 670 680
680 690 700 710 720
pF1KE1 TPRAHLFTQDPAMPPLTPPNTLAQLEEACRRLAEVSK-----PPKQRCCVASQQRDRNHS
: .::: :::.::: :: :.::::: ::: : : : ::: ..: :
NP_003 QP-SHLFIQDPTMPPHPAPNPLTQLEEARRRLEEEEKRASRAPSKQRYVQEVMRRGR---
690 700 710 720 730
730 740 750 760 770 780
pF1KE1 ATVQTGATPF-------SNPSLAPEDHKEPKKLAGVHALQASELVVTYFFCGEEIPYRRM
: :. . .: :. :. . . .:..: : . .::.:.:::: :::: .
NP_003 ACVRPACAPVLHVVPAVSDMELSETETRSQRKVGGGSAQPCDSIVVAYYFCGEPIPYRTL
740 750 760 770 780 790
790 800 810 820 830 840
pF1KE1 LKAQSLTLGHFKEQLSKKGNYRYYFKKASDEFACGAVFEEIWEDETVLPMYEGRILGKVE
......:::.::: :.:::.:::::::.:::: ::.::::. :::.:::..: .:.::::
NP_003 VRGRAVTLGQFKELLTKKGSYRYYFKKVSDEFDCGVVFEEVREDEAVLPVFEEKIIGKVE
800 810 820 830 840 850
pF1KE1 RID
..:
NP_003 KVD
860
>>XP_011520986 (OMIM: 114550,603816,607864) axin-1 isofo (867 aa)
initn: 1821 init1: 381 opt: 1072 Z-score: 844.8 bits: 167.4 E(91774): 2.7e-40
Smith-Waterman score: 2092; 43.1% identity (66.2% similar) in 897 aa overlap (12-843:11-867)
10 20 30 40 50
pF1KE1 MSSAMLVTCLPDPSSSFREDAPRPPVPGEEGETPPCQPG-------VGKGQVTKPMSVSS
: ..:: :::::::::::::: .: ::: : . ..
XP_011 MNIQEQGFPLDLGASFTEDAPRPPVPGEEGELVSTDPRPASYSFCSGKGVGIKGETSTA
10 20 30 40 50
60 70 80 90 100 110
pF1KE1 NTRRNEDGLG-EPEGRASPDSPLTRWTKSLHSLLGDQDGAYLFRTFLEREKCVDTLDFWF
. ::.. :: :::: ::: : .:..:::::: :::: ::::::..: :.: :::::
XP_011 TPRRSDLDLGYEPEGSASPTPPYLKWAESLHSLLDDQDGISLFRTFLKQEGCADLLDFWF
60 70 80 90 100 110
120 130 140 150 160
pF1KE1 ACNGFRQMNLKDT---KTLRVAKAIYKRYI-ENNSIVSKQLKPATKTYIRDGIKKQQIDS
::.:::... :. : :..:.:::..:: .::.:::.: :::::..:. : :: ::
XP_011 ACTGFRKLEPCDSNEEKRLKLARAIYRKYILDNNGIVSRQTKPATKSFIKGCIMKQLIDP
120 130 140 150 160 170
170 180 190 200 210 220
pF1KE1 IMFDQAQTEIQSVMEENAYQMFLTSDIYLEYVRSGGENTAYMSN--GGLGSLKVVCGYLP
::::::::::..::::.: :: :::::::.:.:.:. :. .: :. : . ::::
XP_011 AMFDQAQTEIQATMEENTYPSFLKSDIYLEYTRTGSESPKVCSDQSSGSGTGKGISGYLP
180 190 200 210 220 230
230 240 250 260 270
pF1KE1 TLNEEEEWTC-----------ADFKCKLSPTVVGLSSKTLRATASVRSTETVDSGYRSFK
::::.::: : : .: : . : . . :...: : .: . : :..
XP_011 TLNEDEEWKCDQDMDEDDGRDAAPPGRL-PQKLLLETAAPRVSSSRRYSEGREFRYGSWR
240 250 260 270 280 290
280 290 300 310 320 330
pF1KE1 RSDPVNPYHIGSGYVFAPATSANDSEISSDALTDDSMSMTDSSVDGIPPYRVGSKKQLQR
.:::::....::..:::::::::: .: . :..:.::::::::::::. .:: .:
XP_011 --EPVNPYYVNAGYALAPATSANDSEQQSLSSDADTLSLTDSSVDGIPPYRI--RKQHRR
300 310 320 330 340 350
340 350 360 370 380 390
pF1KE1 EMHRSVKANGQVSLPHFP-----RTHRLPKEMTPVEPATFAAELISRLEKLKLELESRHS
::..::..::.: :::.: ::.:.:::. ::: :: ::: ::: .. :....
XP_011 EMQESVQVNGRVPLPHIPSCPSQRTYRVPKEVR-VEPQKFAEELIHRLEAVQRTREAEEK
360 370 380 390 400 410
400 410 420 430
pF1KE1 LEERLQQIREDEERE------GSELTLNSREGAPTQH--PLSLLPSG------SYEEDPQ
:::::...: .:: : : .. ::. : : . : ..::.:.
XP_011 LEERLKRVRMEEEGEDGDPSSGPPGPCHKLPPAPAWHHFPPRCVDMGCAGLRDAHEENPE
420 430 440 450 460 470
440 450 460 470 480 490
pF1KE1 TILDDHLSRVLKTPGCQSPGVGRYSPRSRSPDHHHHHHSQYHSLLPPGGKLPPAAASPGA
.:::.:..:::.::: :::: : :::: : . .: . : ::.. :
XP_011 SILDEHVQRVLRTPGRQSPG-----PGHRSPDSGHV------AKMPVA--LGGAASGHGK
480 490 500 510 520
500 510 520 530 540 550
pF1KE1 -CPLLGGK-GFVTKQTTKHVHHHYIHHHAVPKTKEEIEAEATQRVHCFCPGGSEYYCY-S
: :.: . . .::::: ::.. . ::..:::::.:.. : : . . .
XP_011 HVPKSGAKLDAAGLHHHRHVHHHV--HHSTARPKEQVEAEATRRAQSSFAWGLEPHSHGA
530 540 550 560 570
560 570 580 590 600 610
pF1KE1 KCKSHSKAPETMPSEQFGGSRGSTLP---KRNGKGTEPGLALPAREGGAPGGAGALQLPR
. ...:.. . :. . : .... . :::.: .: : . .. .::..
XP_011 RSRGYSESVGAAPNASDGLAHSGKVGVACKRNAKKAESGKSASTE---VPGAS-------
580 590 600 610 620
620 630 640 650 660
pF1KE1 EEGDRSQDVWQWMLESERQ-SKPK--PHSAQSTKKAYPLESARSSPGERASRHHLWGGNS
:.....: . ::..:.:.. :. . :....:.: : :..: : : .: :.: .
XP_011 EDAEKNQKIMQWIIEGEKEISRHRRTGHGSSGTRKPQPHENSR--P---LSLEHPWAGPQ
630 640 650 660 670 680
670 680 690 700 710 720
pF1KE1 GHPRTTPRAHLFTQDPAMPPLTPPNTLAQLEEACRRLAEVSK-----PPKQRCCVASQQR
. . : .::: :::.::: :: :.::::: ::: : : : ::: ..:
XP_011 LRTSVQP-SHLFIQDPTMPPHPAPNPLTQLEEARRRLEEEEKRASRAPSKQRYVQEVMRR
690 700 710 720 730 740
730 740 750 760 770
pF1KE1 DRNHSATVQTGATPF-------SNPSLAPEDHKEPKKLAGVHALQASELVVTYFFCGEEI
: : :. . .: :. :. . . .:..: : . .::.:.:::: :
XP_011 GR---ACVRPACAPVLHVVPAVSDMELSETETRSQRKVGGGSAQPCDSIVVAYYFCGEPI
750 760 770 780 790
780 790 800 810 820 830
pF1KE1 PYRRMLKAQSLTLGHFKEQLSKKGNYRYYFKKASDEFACGAVFEEIWEDETVLPMYEGRI
::: .......:::.::: :.:::.:::::::.:::: ::.::::. :::.:::..: .:
XP_011 PYRTLVRGRAVTLGQFKELLTKKGSYRYYFKKVSDEFDCGVVFEEVREDEAVLPVFEEKI
800 810 820 830 840 850
840
pF1KE1 LGKVERID
.::::..:
XP_011 IGKVEKVD
860
>>XP_011520984 (OMIM: 114550,603816,607864) axin-1 isofo (916 aa)
initn: 1821 init1: 381 opt: 1072 Z-score: 844.5 bits: 167.4 E(91774): 2.9e-40
Smith-Waterman score: 2092; 43.1% identity (66.2% similar) in 897 aa overlap (12-843:60-916)
10 20 30
pF1KE1 MSSAMLVTCLPDPSSSFREDAPRPPVPGEEGETPPCQPG--
: ..:: :::::::::::::: .:
XP_011 AVSTDVLGCSAHCSLTQSPKMNIQEQGFPLDLGASFTEDAPRPPVPGEEGELVSTDPRPA
30 40 50 60 70 80
40 50 60 70 80 90
pF1KE1 -----VGKGQVTKPMSVSSNTRRNEDGLG-EPEGRASPDSPLTRWTKSLHSLLGDQDGAY
::: : . ... ::.. :: :::: ::: : .:..:::::: ::::
XP_011 SYSFCSGKGVGIKGETSTATPRRSDLDLGYEPEGSASPTPPYLKWAESLHSLLDDQDGIS
90 100 110 120 130 140
100 110 120 130 140
pF1KE1 LFRTFLEREKCVDTLDFWFACNGFRQMNLKDT---KTLRVAKAIYKRYI-ENNSIVSKQL
::::::..: :.: :::::::.:::... :. : :..:.:::..:: .::.:::.:
XP_011 LFRTFLKQEGCADLLDFWFACTGFRKLEPCDSNEEKRLKLARAIYRKYILDNNGIVSRQT
150 160 170 180 190 200
150 160 170 180 190 200
pF1KE1 KPATKTYIRDGIKKQQIDSIMFDQAQTEIQSVMEENAYQMFLTSDIYLEYVRSGGENTAY
:::::..:. : :: :: ::::::::::..::::.: :: :::::::.:.:.:.
XP_011 KPATKSFIKGCIMKQLIDPAMFDQAQTEIQATMEENTYPSFLKSDIYLEYTRTGSESPKV
210 220 230 240 250 260
210 220 230 240 250
pF1KE1 MSN--GGLGSLKVVCGYLPTLNEEEEWTC-----------ADFKCKLSPTVVGLSSKTLR
:. .: :. : . ::::::::.::: : : .: : . : . . :
XP_011 CSDQSSGSGTGKGISGYLPTLNEDEEWKCDQDMDEDDGRDAAPPGRL-PQKLLLETAAPR
270 280 290 300 310 320
260 270 280 290 300 310
pF1KE1 ATASVRSTETVDSGYRSFKRSDPVNPYHIGSGYVFAPATSANDSEISSDALTDDSMSMTD
...: : .: . : :.. .:::::....::..:::::::::: .: . :..:.::
XP_011 VSSSRRYSEGREFRYGSWR--EPVNPYYVNAGYALAPATSANDSEQQSLSSDADTLSLTD
330 340 350 360 370 380
320 330 340 350 360 370
pF1KE1 SSVDGIPPYRVGSKKQLQREMHRSVKANGQVSLPHFP-----RTHRLPKEMTPVEPATFA
::::::::::. .:: .:::..::..::.: :::.: ::.:.:::. ::: ::
XP_011 SSVDGIPPYRI--RKQHRREMQESVQVNGRVPLPHIPSCPSQRTYRVPKEVR-VEPQKFA
390 400 410 420 430 440
380 390 400 410 420
pF1KE1 AELISRLEKLKLELESRHSLEERLQQIREDEERE------GSELTLNSREGAPTQH--PL
::: ::: .. :....:::::...: .:: : : .. ::. : :
XP_011 EELIHRLEAVQRTREAEEKLEERLKRVRMEEEGEDGDPSSGPPGPCHKLPPAPAWHHFPP
450 460 470 480 490 500
430 440 450 460 470
pF1KE1 SLLPSG------SYEEDPQTILDDHLSRVLKTPGCQSPGVGRYSPRSRSPDHHHHHHSQY
. : ..::.:..:::.:..:::.::: :::: : :::: :
XP_011 RCVDMGCAGLRDAHEENPESILDEHVQRVLRTPGRQSPG-----PGHRSPDSGHV-----
510 520 530 540 550
480 490 500 510 520 530
pF1KE1 HSLLPPGGKLPPAAASPGA-CPLLGGK-GFVTKQTTKHVHHHYIHHHAVPKTKEEIEAEA
. .: . : ::.. : : :.: . . .::::: ::.. . ::..::::
XP_011 -AKMPVA--LGGAASGHGKHVPKSGAKLDAAGLHHHRHVHHHV--HHSTARPKEQVEAEA
560 570 580 590 600
540 550 560 570 580 590
pF1KE1 TQRVHCFCPGGSEYYCY-SKCKSHSKAPETMPSEQFGGSRGSTLP---KRNGKGTEPGLA
:.:.. : : . . .. ...:.. . :. . : .... . :::.: .: : .
XP_011 TRRAQSSFAWGLEPHSHGARSRGYSESVGAAPNASDGLAHSGKVGVACKRNAKKAESGKS
610 620 630 640 650 660
600 610 620 630 640
pF1KE1 LPAREGGAPGGAGALQLPREEGDRSQDVWQWMLESERQ-SKPK--PHSAQSTKKAYPLES
.. .::.. :.....: . ::..:.:.. :. . :....:.: : :.
XP_011 ASTE---VPGAS-------EDAEKNQKIMQWIIEGEKEISRHRRTGHGSSGTRKPQPHEN
670 680 690 700 710
650 660 670 680 690 700
pF1KE1 ARSSPGERASRHHLWGGNSGHPRTTPRAHLFTQDPAMPPLTPPNTLAQLEEACRRLAEVS
.: : : .: :.: . . . : .::: :::.::: :: :.::::: ::: :
XP_011 SR--P---LSLEHPWAGPQLRTSVQP-SHLFIQDPTMPPHPAPNPLTQLEEARRRLEEEE
720 730 740 750 760 770
710 720 730 740 750
pF1KE1 K-----PPKQRCCVASQQRDRNHSATVQTGATPF-------SNPSLAPEDHKEPKKLAGV
: : ::: ..: : : :. . .: :. :. . . .:..:
XP_011 KRASRAPSKQRYVQEVMRRGR---ACVRPACAPVLHVVPAVSDMELSETETRSQRKVGGG
780 790 800 810 820
760 770 780 790 800 810
pF1KE1 HALQASELVVTYFFCGEEIPYRRMLKAQSLTLGHFKEQLSKKGNYRYYFKKASDEFACGA
: . .::.:.:::: :::: .......:::.::: :.:::.:::::::.:::: ::.
XP_011 SAQPCDSIVVAYYFCGEPIPYRTLVRGRAVTLGQFKELLTKKGSYRYYFKKVSDEFDCGV
830 840 850 860 870 880
820 830 840
pF1KE1 VFEEIWEDETVLPMYEGRILGKVERID
::::. :::.:::..: .:.::::..:
XP_011 VFEEVREDEAVLPVFEEKIIGKVEKVD
890 900 910
843 residues in 1 query sequences
64092750 residues in 91774 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Jul 16 15:50:42 2019 done: Tue Jul 16 15:50:43 2019
Total Scan time: 6.970 Total Display time: 0.200
Function used was FASTA [36.3.4 Apr, 2011]