FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE1535, 777 aa 1>>>pF1KE1535 777 - 777 aa - 777 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 14.5014+/-0.00045; mu= -20.4362+/- 0.028 mean_var=569.8987+/-120.033, 0's: 0 Z-trim(123.5): 34 B-trim: 601 in 1/59 Lambda= 0.053725 statistics sampled from 43356 (43412) to 43356 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.785), E-opt: 0.2 (0.509), width: 16 Scan time: 12.970 The best scores are: opt bits E(85289) NP_004703 (OMIM: 604375) hepatocyte growth factor- ( 777) 5205 418.5 5.2e-116 XP_016880786 (OMIM: 604375) PREDICTED: hepatocyte ( 768) 5128 412.6 3.2e-114 XP_011523765 (OMIM: 604375) PREDICTED: hepatocyte ( 777) 4947 398.5 5.5e-110 XP_016880787 (OMIM: 604375) PREDICTED: hepatocyte ( 602) 4039 328.1 6.9e-89 >>NP_004703 (OMIM: 604375) hepatocyte growth factor-regu (777 aa) initn: 5205 init1: 5205 opt: 5205 Z-score: 2203.7 bits: 418.5 E(85289): 5.2e-116 Smith-Waterman score: 5205; 100.0% identity (100.0% similar) in 777 aa overlap (1-777:1-777) 10 20 30 40 50 60 pF1KE1 MGRGSGTFERLLDKATSQLLLETDWESILQICDLIRQGDTQAKYAVNSIKKKVNDKNPHV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 MGRGSGTFERLLDKATSQLLLETDWESILQICDLIRQGDTQAKYAVNSIKKKVNDKNPHV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 ALYALEVMESVVKNCGQTVHDEVANKQTMEELKDLLKRQVEVNVRNKILYLIQAWAHAFR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 ALYALEVMESVVKNCGQTVHDEVANKQTMEELKDLLKRQVEVNVRNKILYLIQAWAHAFR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 NEPKYKVVQDTYQIMKVEGHVFPEFKESDAMFAAERAPDWVDAEECHRCRVQFGVMTRKH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 NEPKYKVVQDTYQIMKVEGHVFPEFKESDAMFAAERAPDWVDAEECHRCRVQFGVMTRKH 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 HCRACGQIFCGKCSSKYSTIPKFGIEKEVRVCEPCYEQLNRKAEGKATSTTELPPEYLTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 HCRACGQIFCGKCSSKYSTIPKFGIEKEVRVCEPCYEQLNRKAEGKATSTTELPPEYLTS 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE1 PLSQQSQLPPKRDETALQEEEELQLALALSQSEAEEKERLRQKSTYTSYPKAEPMPSASS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 PLSQQSQLPPKRDETALQEEEELQLALALSQSEAEEKERLRQKSTYTSYPKAEPMPSASS 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE1 APPASSLYSSPVNSSAPLAEDIDPELARYLNRNYWEKKQEEARKSPTPSAPVPLTEPAAQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 APPASSLYSSPVNSSAPLAEDIDPELARYLNRNYWEKKQEEARKSPTPSAPVPLTEPAAQ 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE1 PGEGHAAPTNVVENPLPETDSQPIPPSGGPFSEPQFHNGESEESHEQFLKALQNAVTTFV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 PGEGHAAPTNVVENPLPETDSQPIPPSGGPFSEPQFHNGESEESHEQFLKALQNAVTTFV 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE1 NRMKSNHMRGRSITNDSAVLSLFQSINGMHPQLLELLNQLDERRLYYEGLQDKLAQIRDA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 NRMKSNHMRGRSITNDSAVLSLFQSINGMHPQLLELLNQLDERRLYYEGLQDKLAQIRDA 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE1 RGALSALREEHREKLRRAAEEAERQRQIQLAQKLEIMRQKKQEYLEVQRQLAIQRLQEQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 RGALSALREEHREKLRRAAEEAERQRQIQLAQKLEIMRQKKQEYLEVQRQLAIQRLQEQE 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE1 KERQMRLEQQKQTVQMRAQMPAFPLPYAQLQAMPAAGGVLYQPSGPASFPSTFSPAGSVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 KERQMRLEQQKQTVQMRAQMPAFPLPYAQLQAMPAAGGVLYQPSGPASFPSTFSPAGSVE 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE1 GSPMHGVYMSQPAPAAGPYPSMPSTAADPSMVSAYMYPAGATGAQAAPQAQAGPTASPAY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 GSPMHGVYMSQPAPAAGPYPSMPSTAADPSMVSAYMYPAGATGAQAAPQAQAGPTASPAY 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE1 SSYQPTPTAGYQNVASQAPQSLPAISQPPQSSTMGYMGSQSVSMGYQPYNMQNLMTTLPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 SSYQPTPTAGYQNVASQAPQSLPAISQPPQSSTMGYMGSQSVSMGYQPYNMQNLMTTLPS 670 680 690 700 710 720 730 740 750 760 770 pF1KE1 QDASLPPQQPYIAGQQPMYQQMAPSGGPPQQQPPVAQQPQAQGPPAQGSEAQLISFD ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 QDASLPPQQPYIAGQQPMYQQMAPSGGPPQQQPPVAQQPQAQGPPAQGSEAQLISFD 730 740 750 760 770 >>XP_016880786 (OMIM: 604375) PREDICTED: hepatocyte grow (768 aa) initn: 5128 init1: 5128 opt: 5128 Z-score: 2171.5 bits: 412.6 E(85289): 3.2e-114 Smith-Waterman score: 5128; 99.7% identity (99.9% similar) in 767 aa overlap (11-777:2-768) 10 20 30 40 50 60 pF1KE1 MGRGSGTFERLLDKATSQLLLETDWESILQICDLIRQGDTQAKYAVNSIKKKVNDKNPHV . :::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MMTDKATSQLLLETDWESILQICDLIRQGDTQAKYAVNSIKKKVNDKNPHV 10 20 30 40 50 70 80 90 100 110 120 pF1KE1 ALYALEVMESVVKNCGQTVHDEVANKQTMEELKDLLKRQVEVNVRNKILYLIQAWAHAFR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ALYALEVMESVVKNCGQTVHDEVANKQTMEELKDLLKRQVEVNVRNKILYLIQAWAHAFR 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE1 NEPKYKVVQDTYQIMKVEGHVFPEFKESDAMFAAERAPDWVDAEECHRCRVQFGVMTRKH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NEPKYKVVQDTYQIMKVEGHVFPEFKESDAMFAAERAPDWVDAEECHRCRVQFGVMTRKH 120 130 140 150 160 170 190 200 210 220 230 240 pF1KE1 HCRACGQIFCGKCSSKYSTIPKFGIEKEVRVCEPCYEQLNRKAEGKATSTTELPPEYLTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HCRACGQIFCGKCSSKYSTIPKFGIEKEVRVCEPCYEQLNRKAEGKATSTTELPPEYLTS 180 190 200 210 220 230 250 260 270 280 290 300 pF1KE1 PLSQQSQLPPKRDETALQEEEELQLALALSQSEAEEKERLRQKSTYTSYPKAEPMPSASS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PLSQQSQLPPKRDETALQEEEELQLALALSQSEAEEKERLRQKSTYTSYPKAEPMPSASS 240 250 260 270 280 290 310 320 330 340 350 360 pF1KE1 APPASSLYSSPVNSSAPLAEDIDPELARYLNRNYWEKKQEEARKSPTPSAPVPLTEPAAQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 APPASSLYSSPVNSSAPLAEDIDPELARYLNRNYWEKKQEEARKSPTPSAPVPLTEPAAQ 300 310 320 330 340 350 370 380 390 400 410 420 pF1KE1 PGEGHAAPTNVVENPLPETDSQPIPPSGGPFSEPQFHNGESEESHEQFLKALQNAVTTFV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PGEGHAAPTNVVENPLPETDSQPIPPSGGPFSEPQFHNGESEESHEQFLKALQNAVTTFV 360 370 380 390 400 410 430 440 450 460 470 480 pF1KE1 NRMKSNHMRGRSITNDSAVLSLFQSINGMHPQLLELLNQLDERRLYYEGLQDKLAQIRDA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NRMKSNHMRGRSITNDSAVLSLFQSINGMHPQLLELLNQLDERRLYYEGLQDKLAQIRDA 420 430 440 450 460 470 490 500 510 520 530 540 pF1KE1 RGALSALREEHREKLRRAAEEAERQRQIQLAQKLEIMRQKKQEYLEVQRQLAIQRLQEQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RGALSALREEHREKLRRAAEEAERQRQIQLAQKLEIMRQKKQEYLEVQRQLAIQRLQEQE 480 490 500 510 520 530 550 560 570 580 590 600 pF1KE1 KERQMRLEQQKQTVQMRAQMPAFPLPYAQLQAMPAAGGVLYQPSGPASFPSTFSPAGSVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KERQMRLEQQKQTVQMRAQMPAFPLPYAQLQAMPAAGGVLYQPSGPASFPSTFSPAGSVE 540 550 560 570 580 590 610 620 630 640 650 660 pF1KE1 GSPMHGVYMSQPAPAAGPYPSMPSTAADPSMVSAYMYPAGATGAQAAPQAQAGPTASPAY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GSPMHGVYMSQPAPAAGPYPSMPSTAADPSMVSAYMYPAGATGAQAAPQAQAGPTASPAY 600 610 620 630 640 650 670 680 690 700 710 720 pF1KE1 SSYQPTPTAGYQNVASQAPQSLPAISQPPQSSTMGYMGSQSVSMGYQPYNMQNLMTTLPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SSYQPTPTAGYQNVASQAPQSLPAISQPPQSSTMGYMGSQSVSMGYQPYNMQNLMTTLPS 660 670 680 690 700 710 730 740 750 760 770 pF1KE1 QDASLPPQQPYIAGQQPMYQQMAPSGGPPQQQPPVAQQPQAQGPPAQGSEAQLISFD ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QDASLPPQQPYIAGQQPMYQQMAPSGGPPQQQPPVAQQPQAQGPPAQGSEAQLISFD 720 730 740 750 760 >>XP_011523765 (OMIM: 604375) PREDICTED: hepatocyte grow (777 aa) initn: 4946 init1: 4946 opt: 4947 Z-score: 2095.7 bits: 398.5 E(85289): 5.5e-110 Smith-Waterman score: 4947; 99.2% identity (99.5% similar) in 749 aa overlap (1-748:1-749) 10 20 30 40 50 60 pF1KE1 MGRGSGTFERLLDKATSQLLLETDWESILQICDLIRQGDTQAKYAVNSIKKKVNDKNPHV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MGRGSGTFERLLDKATSQLLLETDWESILQICDLIRQGDTQAKYAVNSIKKKVNDKNPHV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 ALYALEVMESVVKNCGQTVHDEVANKQTMEELKDLLKRQVEVNVRNKILYLIQAWAHAFR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ALYALEVMESVVKNCGQTVHDEVANKQTMEELKDLLKRQVEVNVRNKILYLIQAWAHAFR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 NEPKYKVVQDTYQIMKVEGHVFPEFKESDAMFAAERAPDWVDAEECHRCRVQFGVMTRKH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NEPKYKVVQDTYQIMKVEGHVFPEFKESDAMFAAERAPDWVDAEECHRCRVQFGVMTRKH 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 HCRACGQIFCGKCSSKYSTIPKFGIEKEVRVCEPCYEQLNRKAEGKATSTTELPPEYLTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 HCRACGQIFCGKCSSKYSTIPKFGIEKEVRVCEPCYEQLNRKAEGKATSTTELPPEYLTS 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE1 PLSQQSQLPPKRDETALQEEEELQLALALSQSEAEEKERLRQKSTYTSYPKAEPMPSASS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PLSQQSQLPPKRDETALQEEEELQLALALSQSEAEEKERLRQKSTYTSYPKAEPMPSASS 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE1 APPASSLYSSPVNSSAPLAEDIDPELARYLNRNYWEKKQEEARKSPTPSAPVPLTEPAAQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 APPASSLYSSPVNSSAPLAEDIDPELARYLNRNYWEKKQEEARKSPTPSAPVPLTEPAAQ 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE1 PGEGHAAPTNVVENPLPETDSQPIPPSGGPFSEPQFHNGESEESHEQFLKALQNAVTTFV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PGEGHAAPTNVVENPLPETDSQPIPPSGGPFSEPQFHNGESEESHEQFLKALQNAVTTFV 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE1 NRMKSNHMRGRSITNDSAVLSLFQSINGMHPQLLELLNQLDERRLYYEGLQDKLAQIRDA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NRMKSNHMRGRSITNDSAVLSLFQSINGMHPQLLELLNQLDERRLYYEGLQDKLAQIRDA 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE1 RGALSALREEHREKLRRAAEEAERQRQIQLAQKLEIMRQKKQEYLEVQRQLAIQRLQEQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RGALSALREEHREKLRRAAEEAERQRQIQLAQKLEIMRQKKQEYLEVQRQLAIQRLQEQE 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE1 KERQMRLEQQKQTVQMRAQMPAFPLPYAQLQAMPAAGGVLYQPSGPASFPSTFSPAGSVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KERQMRLEQQKQTVQMRAQMPAFPLPYAQLQAMPAAGGVLYQPSGPASFPSTFSPAGSVE 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE1 GSPMHGVYMSQPAPAAGPYPSMPSTAADPSMVSAYMYPAGATGAQAAPQAQAGPTASPAY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GSPMHGVYMSQPAPAAGPYPSMPSTAADPSMVSAYMYPAGATGAQAAPQAQAGPTASPAY 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE1 SSYQPTPTAGYQNVASQAPQSLPAISQPPQSSTMGYMGSQSVSMGYQPYNMQNLMTTLPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SSYQPTPTAGYQNVASQAPQSLPAISQPPQSSTMGYMGSQSVSMGYQPYNMQNLMTTLPS 670 680 690 700 710 720 730 740 750 760 770 pF1KE1 QDASLPPQQPYIAGQQPMYQQ-MAPSGGPPQQQPPVAQQPQAQGPPAQGSEAQLISFD ::::::::::::::::::::: . . :: XP_011 QDASLPPQQPYIAGQQPMYQQGETHTRGPFSADRTRTQVSGQIRASASVDRKNREFT 730 740 750 760 770 >>XP_016880787 (OMIM: 604375) PREDICTED: hepatocyte grow (602 aa) initn: 4039 init1: 4039 opt: 4039 Z-score: 1716.8 bits: 328.1 E(85289): 6.9e-89 Smith-Waterman score: 4039; 100.0% identity (100.0% similar) in 602 aa overlap (176-777:1-602) 150 160 170 180 190 200 pF1KE1 KESDAMFAAERAPDWVDAEECHRCRVQFGVMTRKHHCRACGQIFCGKCSSKYSTIPKFGI :::::::::::::::::::::::::::::: XP_016 MTRKHHCRACGQIFCGKCSSKYSTIPKFGI 10 20 30 210 220 230 240 250 260 pF1KE1 EKEVRVCEPCYEQLNRKAEGKATSTTELPPEYLTSPLSQQSQLPPKRDETALQEEEELQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EKEVRVCEPCYEQLNRKAEGKATSTTELPPEYLTSPLSQQSQLPPKRDETALQEEEELQL 40 50 60 70 80 90 270 280 290 300 310 320 pF1KE1 ALALSQSEAEEKERLRQKSTYTSYPKAEPMPSASSAPPASSLYSSPVNSSAPLAEDIDPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ALALSQSEAEEKERLRQKSTYTSYPKAEPMPSASSAPPASSLYSSPVNSSAPLAEDIDPE 100 110 120 130 140 150 330 340 350 360 370 380 pF1KE1 LARYLNRNYWEKKQEEARKSPTPSAPVPLTEPAAQPGEGHAAPTNVVENPLPETDSQPIP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LARYLNRNYWEKKQEEARKSPTPSAPVPLTEPAAQPGEGHAAPTNVVENPLPETDSQPIP 160 170 180 190 200 210 390 400 410 420 430 440 pF1KE1 PSGGPFSEPQFHNGESEESHEQFLKALQNAVTTFVNRMKSNHMRGRSITNDSAVLSLFQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PSGGPFSEPQFHNGESEESHEQFLKALQNAVTTFVNRMKSNHMRGRSITNDSAVLSLFQS 220 230 240 250 260 270 450 460 470 480 490 500 pF1KE1 INGMHPQLLELLNQLDERRLYYEGLQDKLAQIRDARGALSALREEHREKLRRAAEEAERQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 INGMHPQLLELLNQLDERRLYYEGLQDKLAQIRDARGALSALREEHREKLRRAAEEAERQ 280 290 300 310 320 330 510 520 530 540 550 560 pF1KE1 RQIQLAQKLEIMRQKKQEYLEVQRQLAIQRLQEQEKERQMRLEQQKQTVQMRAQMPAFPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RQIQLAQKLEIMRQKKQEYLEVQRQLAIQRLQEQEKERQMRLEQQKQTVQMRAQMPAFPL 340 350 360 370 380 390 570 580 590 600 610 620 pF1KE1 PYAQLQAMPAAGGVLYQPSGPASFPSTFSPAGSVEGSPMHGVYMSQPAPAAGPYPSMPST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PYAQLQAMPAAGGVLYQPSGPASFPSTFSPAGSVEGSPMHGVYMSQPAPAAGPYPSMPST 400 410 420 430 440 450 630 640 650 660 670 680 pF1KE1 AADPSMVSAYMYPAGATGAQAAPQAQAGPTASPAYSSYQPTPTAGYQNVASQAPQSLPAI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AADPSMVSAYMYPAGATGAQAAPQAQAGPTASPAYSSYQPTPTAGYQNVASQAPQSLPAI 460 470 480 490 500 510 690 700 710 720 730 740 pF1KE1 SQPPQSSTMGYMGSQSVSMGYQPYNMQNLMTTLPSQDASLPPQQPYIAGQQPMYQQMAPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SQPPQSSTMGYMGSQSVSMGYQPYNMQNLMTTLPSQDASLPPQQPYIAGQQPMYQQMAPS 520 530 540 550 560 570 750 760 770 pF1KE1 GGPPQQQPPVAQQPQAQGPPAQGSEAQLISFD :::::::::::::::::::::::::::::::: XP_016 GGPPQQQPPVAQQPQAQGPPAQGSEAQLISFD 580 590 600 777 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 20:14:30 2016 done: Sun Nov 6 20:14:32 2016 Total Scan time: 12.970 Total Display time: 0.050 Function used was FASTA [36.3.4 Apr, 2011]