FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE0966, 512 aa 1>>>pF1KE0966 512 - 512 aa - 512 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 8.1853+/-0.000438; mu= 7.6765+/- 0.027 mean_var=614.8484+/-143.546, 0's: 0 Z-trim(120.3): 77 B-trim: 0 in 0/59 Lambda= 0.051724 statistics sampled from 35222 (35301) to 35222 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.745), E-opt: 0.2 (0.414), width: 16 Scan time: 10.730 The best scores are: opt bits E(85289) NP_001097 (OMIM: 602730,613751) activin receptor t ( 512) 3588 283.5 1e-75 XP_016863003 (OMIM: 602730,613751) PREDICTED: acti ( 526) 3473 274.9 4e-73 XP_016863005 (OMIM: 602730,613751) PREDICTED: acti ( 511) 3465 274.3 6e-73 XP_005265640 (OMIM: 602730,613751) PREDICTED: acti ( 533) 3465 274.3 6.1e-73 XP_016863004 (OMIM: 602730,613751) PREDICTED: acti ( 518) 3461 274.0 7.5e-73 NP_001265508 (OMIM: 102581) activin receptor type- ( 513) 2533 204.7 5.2e-52 NP_001607 (OMIM: 102581) activin receptor type-2A ( 513) 2533 204.7 5.2e-52 NP_001265509 (OMIM: 102581) activin receptor type- ( 405) 2038 167.6 6.2e-41 XP_011532347 (OMIM: 133239,190182,610168,614331) P ( 532) 919 84.3 9.5e-16 XP_016862595 (OMIM: 133239,190182,610168,614331) P ( 532) 919 84.3 9.5e-16 NP_003233 (OMIM: 133239,190182,610168,614331) TGF- ( 567) 919 84.4 9.8e-16 XP_011532345 (OMIM: 133239,190182,610168,614331) P ( 576) 919 84.4 9.9e-16 NP_001020018 (OMIM: 133239,190182,610168,614331) T ( 592) 919 84.4 1e-15 XP_011509989 (OMIM: 178600,265450,600799) PREDICTE (1037) 819 77.4 2.2e-13 NP_001195 (OMIM: 178600,265450,600799) bone morpho (1038) 819 77.4 2.2e-13 NP_001104502 (OMIM: 608981) activin receptor type- ( 413) 764 72.6 2.6e-12 NP_001104501 (OMIM: 608981) activin receptor type- ( 443) 759 72.2 3.5e-12 NP_660302 (OMIM: 608981) activin receptor type-1C ( 493) 759 72.3 3.6e-12 XP_011517252 (OMIM: 132800,190181) PREDICTED: TGF- ( 357) 756 71.8 3.7e-12 NP_001124388 (OMIM: 132800,190181) TGF-beta recept ( 426) 756 72.0 4e-12 XP_011517251 (OMIM: 132800,190181) PREDICTED: TGF- ( 434) 756 72.0 4e-12 XP_011517250 (OMIM: 132800,190181) PREDICTED: TGF- ( 438) 756 72.0 4e-12 XP_016870552 (OMIM: 132800,190181) PREDICTED: TGF- ( 438) 756 72.0 4e-12 NP_004603 (OMIM: 132800,190181) TGF-beta receptor ( 503) 756 72.1 4.3e-12 NP_001293139 (OMIM: 132800,190181) TGF-beta recept ( 507) 756 72.1 4.3e-12 XP_016864048 (OMIM: 112600,603248,609441,616849) P ( 502) 743 71.1 8.4e-12 XP_016864050 (OMIM: 112600,603248,609441,616849) P ( 502) 743 71.1 8.4e-12 XP_016864049 (OMIM: 112600,603248,609441,616849) P ( 502) 743 71.1 8.4e-12 NP_001243721 (OMIM: 112600,603248,609441,616849) b ( 502) 743 71.1 8.4e-12 XP_011530503 (OMIM: 112600,603248,609441,616849) P ( 502) 743 71.1 8.4e-12 NP_001243723 (OMIM: 112600,603248,609441,616849) b ( 502) 743 71.1 8.4e-12 XP_016864047 (OMIM: 112600,603248,609441,616849) P ( 502) 743 71.1 8.4e-12 NP_001194 (OMIM: 112600,603248,609441,616849) bone ( 502) 743 71.1 8.4e-12 NP_001243722 (OMIM: 112600,603248,609441,616849) b ( 532) 743 71.2 8.6e-12 NP_064732 (OMIM: 601300) activin receptor type-1B ( 453) 740 70.8 9.4e-12 NP_004293 (OMIM: 601300) activin receptor type-1B ( 505) 740 70.9 9.8e-12 XP_005246996 (OMIM: 102576,135100) PREDICTED: acti ( 509) 731 70.3 1.6e-11 NP_001104537 (OMIM: 102576,135100) activin recepto ( 509) 731 70.3 1.6e-11 NP_001096 (OMIM: 102576,135100) activin receptor t ( 509) 731 70.3 1.6e-11 XP_005246997 (OMIM: 102576,135100) PREDICTED: acti ( 509) 731 70.3 1.6e-11 XP_011510408 (OMIM: 102576,135100) PREDICTED: acti ( 509) 731 70.3 1.6e-11 XP_006712888 (OMIM: 102576,135100) PREDICTED: acti ( 509) 731 70.3 1.6e-11 XP_011510410 (OMIM: 102576,135100) PREDICTED: acti ( 509) 731 70.3 1.6e-11 XP_011510409 (OMIM: 102576,135100) PREDICTED: acti ( 509) 731 70.3 1.6e-11 NP_004320 (OMIM: 174900,601299,610069) bone morpho ( 532) 717 69.3 3.3e-11 XP_011538406 (OMIM: 174900,601299,610069) PREDICTE ( 532) 717 69.3 3.3e-11 XP_011538405 (OMIM: 174900,601299,610069) PREDICTE ( 532) 717 69.3 3.3e-11 NP_001070869 (OMIM: 600376,601284) serine/threonin ( 503) 678 66.3 2.4e-10 NP_000011 (OMIM: 600376,601284) serine/threonine-p ( 503) 678 66.3 2.4e-10 XP_005269292 (OMIM: 600376,601284) PREDICTED: seri ( 503) 678 66.3 2.4e-10 >>NP_001097 (OMIM: 602730,613751) activin receptor type- (512 aa) initn: 3588 init1: 3588 opt: 3588 Z-score: 1480.2 bits: 283.5 E(85289): 1e-75 Smith-Waterman score: 3588; 100.0% identity (100.0% similar) in 512 aa overlap (1-512:1-512) 10 20 30 40 50 60 pF1KE0 MTAPWVALALLWGSLCAGSGRGEAETRECIYYNANWELERTNQSGLERCEGEQDKRLHCY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MTAPWVALALLWGSLCAGSGRGEAETRECIYYNANWELERTNQSGLERCEGEQDKRLHCY 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 ASWRNSSGTIELVKKGCWLDDFNCYDRQECVATEENPQVYFCCCEGNFCNERFTHLPEAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ASWRNSSGTIELVKKGCWLDDFNCYDRQECVATEENPQVYFCCCEGNFCNERFTHLPEAG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 GPEVTYEPPPTAPTLLTVLAYSLLPIGGLSLIVLLAFWMYRHRKPPYGHVDIHEDPGPPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GPEVTYEPPPTAPTLLTVLAYSLLPIGGLSLIVLLAFWMYRHRKPPYGHVDIHEDPGPPP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 PSPLVGLKPLQLLEIKARGRFGCVWKAQLMNDFVAVKIFPLQDKQSWQSEREIFSTPGMK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PSPLVGLKPLQLLEIKARGRFGCVWKAQLMNDFVAVKIFPLQDKQSWQSEREIFSTPGMK 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE0 HENLLQFIAAEKRGSNLEVELWLITAFHDKGSLTDYLKGNIITWNELCHVAETMSRGLSY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HENLLQFIAAEKRGSNLEVELWLITAFHDKGSLTDYLKGNIITWNELCHVAETMSRGLSY 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE0 LHEDVPWCRGEGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRFEPGKPPGDTHGQVG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LHEDVPWCRGEGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRFEPGKPPGDTHGQVG 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE0 TRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELVSRCKAADGPVDEYMLPFEEEIGQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELVSRCKAADGPVDEYMLPFEEEIGQ 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE0 HPSLEELQEVVVHKKMRPTIKDHWLKHPGLAQLCVTIEECWDHDAEARLSAGCVEERVSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HPSLEELQEVVVHKKMRPTIKDHWLKHPGLAQLCVTIEECWDHDAEARLSAGCVEERVSL 430 440 450 460 470 480 490 500 510 pF1KE0 IRRSVNGTTSDCLVSLVTSVTNVDLPPKESSI :::::::::::::::::::::::::::::::: NP_001 IRRSVNGTTSDCLVSLVTSVTNVDLPPKESSI 490 500 510 >>XP_016863003 (OMIM: 602730,613751) PREDICTED: activin (526 aa) initn: 3470 init1: 3470 opt: 3473 Z-score: 1433.7 bits: 274.9 E(85289): 4e-73 Smith-Waterman score: 3473; 99.4% identity (99.6% similar) in 500 aa overlap (13-512:27-526) 10 20 30 40 pF1KE0 MTAPWVALALLWGSLCAGSGRGEAETRECIYYNANWELERTNQSGL :. :::::::::::::::::::::::::::::: XP_016 MPLPLSGPAMWRSGEPQRLWAWSPQAGDTRAGSGRGEAETRECIYYNANWELERTNQSGL 10 20 30 40 50 60 50 60 70 80 90 100 pF1KE0 ERCEGEQDKRLHCYASWRNSSGTIELVKKGCWLDDFNCYDRQECVATEENPQVYFCCCEG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ERCEGEQDKRLHCYASWRNSSGTIELVKKGCWLDDFNCYDRQECVATEENPQVYFCCCEG 70 80 90 100 110 120 110 120 130 140 150 160 pF1KE0 NFCNERFTHLPEAGGPEVTYEPPPTAPTLLTVLAYSLLPIGGLSLIVLLAFWMYRHRKPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NFCNERFTHLPEAGGPEVTYEPPPTAPTLLTVLAYSLLPIGGLSLIVLLAFWMYRHRKPP 130 140 150 160 170 180 170 180 190 200 210 220 pF1KE0 YGHVDIHEDPGPPPPSPLVGLKPLQLLEIKARGRFGCVWKAQLMNDFVAVKIFPLQDKQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YGHVDIHEDPGPPPPSPLVGLKPLQLLEIKARGRFGCVWKAQLMNDFVAVKIFPLQDKQS 190 200 210 220 230 240 230 240 250 260 270 280 pF1KE0 WQSEREIFSTPGMKHENLLQFIAAEKRGSNLEVELWLITAFHDKGSLTDYLKGNIITWNE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 WQSEREIFSTPGMKHENLLQFIAAEKRGSNLEVELWLITAFHDKGSLTDYLKGNIITWNE 250 260 270 280 290 300 290 300 310 320 330 340 pF1KE0 LCHVAETMSRGLSYLHEDVPWCRGEGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LCHVAETMSRGLSYLHEDVPWCRGEGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRF 310 320 330 340 350 360 350 360 370 380 390 400 pF1KE0 EPGKPPGDTHGQVGTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELVSRCKAADGP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EPGKPPGDTHGQVGTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELVSRCKAADGP 370 380 390 400 410 420 410 420 430 440 450 460 pF1KE0 VDEYMLPFEEEIGQHPSLEELQEVVVHKKMRPTIKDHWLKHPGLAQLCVTIEECWDHDAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VDEYMLPFEEEIGQHPSLEELQEVVVHKKMRPTIKDHWLKHPGLAQLCVTIEECWDHDAE 430 440 450 460 470 480 470 480 490 500 510 pF1KE0 ARLSAGCVEERVSLIRRSVNGTTSDCLVSLVTSVTNVDLPPKESSI :::::::::::::::::::::::::::::::::::::::::::::: XP_016 ARLSAGCVEERVSLIRRSVNGTTSDCLVSLVTSVTNVDLPPKESSI 490 500 510 520 >>XP_016863005 (OMIM: 602730,613751) PREDICTED: activin (511 aa) initn: 3465 init1: 3465 opt: 3465 Z-score: 1430.6 bits: 274.3 E(85289): 6e-73 Smith-Waterman score: 3465; 100.0% identity (100.0% similar) in 495 aa overlap (18-512:17-511) 10 20 30 40 50 60 pF1KE0 MTAPWVALALLWGSLCAGSGRGEAETRECIYYNANWELERTNQSGLERCEGEQDKRLHCY ::::::::::::::::::::::::::::::::::::::::::: XP_016 MMALLRSTNINNLSPVGSGRGEAETRECIYYNANWELERTNQSGLERCEGEQDKRLHCY 10 20 30 40 50 70 80 90 100 110 120 pF1KE0 ASWRNSSGTIELVKKGCWLDDFNCYDRQECVATEENPQVYFCCCEGNFCNERFTHLPEAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ASWRNSSGTIELVKKGCWLDDFNCYDRQECVATEENPQVYFCCCEGNFCNERFTHLPEAG 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE0 GPEVTYEPPPTAPTLLTVLAYSLLPIGGLSLIVLLAFWMYRHRKPPYGHVDIHEDPGPPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GPEVTYEPPPTAPTLLTVLAYSLLPIGGLSLIVLLAFWMYRHRKPPYGHVDIHEDPGPPP 120 130 140 150 160 170 190 200 210 220 230 240 pF1KE0 PSPLVGLKPLQLLEIKARGRFGCVWKAQLMNDFVAVKIFPLQDKQSWQSEREIFSTPGMK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PSPLVGLKPLQLLEIKARGRFGCVWKAQLMNDFVAVKIFPLQDKQSWQSEREIFSTPGMK 180 190 200 210 220 230 250 260 270 280 290 300 pF1KE0 HENLLQFIAAEKRGSNLEVELWLITAFHDKGSLTDYLKGNIITWNELCHVAETMSRGLSY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HENLLQFIAAEKRGSNLEVELWLITAFHDKGSLTDYLKGNIITWNELCHVAETMSRGLSY 240 250 260 270 280 290 310 320 330 340 350 360 pF1KE0 LHEDVPWCRGEGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRFEPGKPPGDTHGQVG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LHEDVPWCRGEGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRFEPGKPPGDTHGQVG 300 310 320 330 340 350 370 380 390 400 410 420 pF1KE0 TRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELVSRCKAADGPVDEYMLPFEEEIGQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELVSRCKAADGPVDEYMLPFEEEIGQ 360 370 380 390 400 410 430 440 450 460 470 480 pF1KE0 HPSLEELQEVVVHKKMRPTIKDHWLKHPGLAQLCVTIEECWDHDAEARLSAGCVEERVSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HPSLEELQEVVVHKKMRPTIKDHWLKHPGLAQLCVTIEECWDHDAEARLSAGCVEERVSL 420 430 440 450 460 470 490 500 510 pF1KE0 IRRSVNGTTSDCLVSLVTSVTNVDLPPKESSI :::::::::::::::::::::::::::::::: XP_016 IRRSVNGTTSDCLVSLVTSVTNVDLPPKESSI 480 490 500 510 >>XP_005265640 (OMIM: 602730,613751) PREDICTED: activin (533 aa) initn: 3465 init1: 3465 opt: 3465 Z-score: 1430.5 bits: 274.3 E(85289): 6.1e-73 Smith-Waterman score: 3465; 100.0% identity (100.0% similar) in 495 aa overlap (18-512:39-533) 10 20 30 40 pF1KE0 MTAPWVALALLWGSLCAGSGRGEAETRECIYYNANWELERTNQSGLE :::::::::::::::::::::::::::::: XP_005 AMWRSGEPQRLWAWSPQAGDTRAGGQPLPKGSGRGEAETRECIYYNANWELERTNQSGLE 10 20 30 40 50 60 50 60 70 80 90 100 pF1KE0 RCEGEQDKRLHCYASWRNSSGTIELVKKGCWLDDFNCYDRQECVATEENPQVYFCCCEGN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 RCEGEQDKRLHCYASWRNSSGTIELVKKGCWLDDFNCYDRQECVATEENPQVYFCCCEGN 70 80 90 100 110 120 110 120 130 140 150 160 pF1KE0 FCNERFTHLPEAGGPEVTYEPPPTAPTLLTVLAYSLLPIGGLSLIVLLAFWMYRHRKPPY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 FCNERFTHLPEAGGPEVTYEPPPTAPTLLTVLAYSLLPIGGLSLIVLLAFWMYRHRKPPY 130 140 150 160 170 180 170 180 190 200 210 220 pF1KE0 GHVDIHEDPGPPPPSPLVGLKPLQLLEIKARGRFGCVWKAQLMNDFVAVKIFPLQDKQSW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GHVDIHEDPGPPPPSPLVGLKPLQLLEIKARGRFGCVWKAQLMNDFVAVKIFPLQDKQSW 190 200 210 220 230 240 230 240 250 260 270 280 pF1KE0 QSEREIFSTPGMKHENLLQFIAAEKRGSNLEVELWLITAFHDKGSLTDYLKGNIITWNEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QSEREIFSTPGMKHENLLQFIAAEKRGSNLEVELWLITAFHDKGSLTDYLKGNIITWNEL 250 260 270 280 290 300 290 300 310 320 330 340 pF1KE0 CHVAETMSRGLSYLHEDVPWCRGEGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRFE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 CHVAETMSRGLSYLHEDVPWCRGEGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRFE 310 320 330 340 350 360 350 360 370 380 390 400 pF1KE0 PGKPPGDTHGQVGTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELVSRCKAADGPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PGKPPGDTHGQVGTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELVSRCKAADGPV 370 380 390 400 410 420 410 420 430 440 450 460 pF1KE0 DEYMLPFEEEIGQHPSLEELQEVVVHKKMRPTIKDHWLKHPGLAQLCVTIEECWDHDAEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DEYMLPFEEEIGQHPSLEELQEVVVHKKMRPTIKDHWLKHPGLAQLCVTIEECWDHDAEA 430 440 450 460 470 480 470 480 490 500 510 pF1KE0 RLSAGCVEERVSLIRRSVNGTTSDCLVSLVTSVTNVDLPPKESSI ::::::::::::::::::::::::::::::::::::::::::::: XP_005 RLSAGCVEERVSLIRRSVNGTTSDCLVSLVTSVTNVDLPPKESSI 490 500 510 520 530 >>XP_016863004 (OMIM: 602730,613751) PREDICTED: activin (518 aa) initn: 3457 init1: 3457 opt: 3461 Z-score: 1428.9 bits: 274.0 E(85289): 7.5e-73 Smith-Waterman score: 3461; 99.0% identity (99.4% similar) in 500 aa overlap (13-512:19-518) 10 20 30 40 50 pF1KE0 MTAPWVALALLWGSLCAGSGRGEAETRECIYYNANWELERTNQSGLERCEGEQD :. .:::::::::::::::::::::::::::::::::::: XP_016 MGAGTRSLRVGVRATRARGTQGKSSGRGEAETRECIYYNANWELERTNQSGLERCEGEQD 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE0 KRLHCYASWRNSSGTIELVKKGCWLDDFNCYDRQECVATEENPQVYFCCCEGNFCNERFT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KRLHCYASWRNSSGTIELVKKGCWLDDFNCYDRQECVATEENPQVYFCCCEGNFCNERFT 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE0 HLPEAGGPEVTYEPPPTAPTLLTVLAYSLLPIGGLSLIVLLAFWMYRHRKPPYGHVDIHE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HLPEAGGPEVTYEPPPTAPTLLTVLAYSLLPIGGLSLIVLLAFWMYRHRKPPYGHVDIHE 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE0 DPGPPPPSPLVGLKPLQLLEIKARGRFGCVWKAQLMNDFVAVKIFPLQDKQSWQSEREIF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DPGPPPPSPLVGLKPLQLLEIKARGRFGCVWKAQLMNDFVAVKIFPLQDKQSWQSEREIF 190 200 210 220 230 240 240 250 260 270 280 290 pF1KE0 STPGMKHENLLQFIAAEKRGSNLEVELWLITAFHDKGSLTDYLKGNIITWNELCHVAETM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 STPGMKHENLLQFIAAEKRGSNLEVELWLITAFHDKGSLTDYLKGNIITWNELCHVAETM 250 260 270 280 290 300 300 310 320 330 340 350 pF1KE0 SRGLSYLHEDVPWCRGEGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRFEPGKPPGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SRGLSYLHEDVPWCRGEGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRFEPGKPPGD 310 320 330 340 350 360 360 370 380 390 400 410 pF1KE0 THGQVGTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELVSRCKAADGPVDEYMLPF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 THGQVGTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELVSRCKAADGPVDEYMLPF 370 380 390 400 410 420 420 430 440 450 460 470 pF1KE0 EEEIGQHPSLEELQEVVVHKKMRPTIKDHWLKHPGLAQLCVTIEECWDHDAEARLSAGCV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EEEIGQHPSLEELQEVVVHKKMRPTIKDHWLKHPGLAQLCVTIEECWDHDAEARLSAGCV 430 440 450 460 470 480 480 490 500 510 pF1KE0 EERVSLIRRSVNGTTSDCLVSLVTSVTNVDLPPKESSI :::::::::::::::::::::::::::::::::::::: XP_016 EERVSLIRRSVNGTTSDCLVSLVTSVTNVDLPPKESSI 490 500 510 >>NP_001265508 (OMIM: 102581) activin receptor type-2A i (513 aa) initn: 2337 init1: 1547 opt: 2533 Z-score: 1054.7 bits: 204.7 E(85289): 5.2e-52 Smith-Waterman score: 2533; 67.3% identity (87.9% similar) in 511 aa overlap (3-512:4-513) 10 20 30 40 50 pF1KE0 MTAPWVALALLWGSLCAGSGRGEAETRECIYYNANWELERTNQSGLERCEGEQDKRLHC : .:.:.. : .:. :..::.::...::::: .::::.:.: : :..::: :: NP_001 MGAAAKLAFAVFLISCSSGAILGRSETQECLFFNANWEKDRTNQTGVEPCYGDKDKRRHC 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE0 YASWRNSSGTIELVKKGCWLDDFNCYDRQECVATEENPQVYFCCCEGNFCNERFTHLPEA .:.:.: ::.::.::.::::::.::::: .:: ...:.:::::::::.:::.:...:: NP_001 FATWKNISGSIEIVKQGCWLDDINCYDRTDCVEKKDSPEVYFCCCEGNMCNEKFSYFPEM 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE0 GGPEVTYEPPPTAPTLLTVLAYSLLPIGGLSLIVLLAFWMYRHRKPPYGHVDIH-EDPGP . : .: : ..: :::.:. .. ::. :::.:::.: : : . .:::: NP_001 EVTQPTSNPVTPKPPYYNILLYSLVPLMLIAGIVICAFWVYRHHKMAYPPVLVPTQDPGP 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE0 PPPSPLVGLKPLQLLEIKARGRFGCVWKAQLMNDFVAVKIFPLQDKQSWQSEREIFSTPG ::::::.:::::::::.::::::::::::::.:..:::::::.:::::::.: :..: :: NP_001 PPPSPLLGLKPLQLLEVKARGRFGCVWKAQLLNEYVAVKIFPIQDKQSWQNEYEVYSLPG 190 200 210 220 230 240 240 250 260 270 280 290 pF1KE0 MKHENLLQFIAAEKRGSNLEVELWLITAFHDKGSLTDYLKGNIITWNELCHVAETMSRGL :::::.::::.:::::....:.::::::::.::::.:.::.:...::::::.::::.::: NP_001 MKHENILQFIGAEKRGTSVDVDLWLITAFHEKGSLSDFLKANVVSWNELCHIAETMARGL 250 260 270 280 290 300 300 310 320 330 340 350 pF1KE0 SYLHEDVPWCRGEGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRFEPGKPPGDTHGQ .:::::.: . .::::.:.:::.::::::::..::: .::::::..:: :: :::::: NP_001 AYLHEDIPGLK-DGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGDTHGQ 310 320 330 340 350 360 370 380 390 400 410 pF1KE0 VGTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELVSRCKAADGPVDEYMLPFEEEI ::::::::::::::::::::::::::::::::::::::.::: ::::::::::::::::: NP_001 VGTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELASRCTAADGPVDEYMLPFEEEI 360 370 380 390 400 410 420 430 440 450 460 470 pF1KE0 GQHPSLEELQEVVVHKKMRPTIKDHWLKHPGLAQLCVTIEECWDHDAEARLSAGCVEERV :::::::..:::::::: ::...:.: :: :.:.:: ::::::::::::::::::: ::. NP_001 GQHPSLEDMQEVVVHKKKRPVLRDYWQKHAGMAMLCETIEECWDHDAEARLSAGCVGERI 420 430 440 450 460 470 480 490 500 510 pF1KE0 SLIRRSVNGTTSDCLVSLVTSVTNVDLPPKESSI . ..: .: :.. .:..:: :::::.::::::. NP_001 TQMQRLTNIITTEDIVTVVTMVTNVDFPPKESSL 480 490 500 510 >>NP_001607 (OMIM: 102581) activin receptor type-2A isof (513 aa) initn: 2337 init1: 1547 opt: 2533 Z-score: 1054.7 bits: 204.7 E(85289): 5.2e-52 Smith-Waterman score: 2533; 67.3% identity (87.9% similar) in 511 aa overlap (3-512:4-513) 10 20 30 40 50 pF1KE0 MTAPWVALALLWGSLCAGSGRGEAETRECIYYNANWELERTNQSGLERCEGEQDKRLHC : .:.:.. : .:. :..::.::...::::: .::::.:.: : :..::: :: NP_001 MGAAAKLAFAVFLISCSSGAILGRSETQECLFFNANWEKDRTNQTGVEPCYGDKDKRRHC 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE0 YASWRNSSGTIELVKKGCWLDDFNCYDRQECVATEENPQVYFCCCEGNFCNERFTHLPEA .:.:.: ::.::.::.::::::.::::: .:: ...:.:::::::::.:::.:...:: NP_001 FATWKNISGSIEIVKQGCWLDDINCYDRTDCVEKKDSPEVYFCCCEGNMCNEKFSYFPEM 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE0 GGPEVTYEPPPTAPTLLTVLAYSLLPIGGLSLIVLLAFWMYRHRKPPYGHVDIH-EDPGP . : .: : ..: :::.:. .. ::. :::.:::.: : : . .:::: NP_001 EVTQPTSNPVTPKPPYYNILLYSLVPLMLIAGIVICAFWVYRHHKMAYPPVLVPTQDPGP 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE0 PPPSPLVGLKPLQLLEIKARGRFGCVWKAQLMNDFVAVKIFPLQDKQSWQSEREIFSTPG ::::::.:::::::::.::::::::::::::.:..:::::::.:::::::.: :..: :: NP_001 PPPSPLLGLKPLQLLEVKARGRFGCVWKAQLLNEYVAVKIFPIQDKQSWQNEYEVYSLPG 190 200 210 220 230 240 240 250 260 270 280 290 pF1KE0 MKHENLLQFIAAEKRGSNLEVELWLITAFHDKGSLTDYLKGNIITWNELCHVAETMSRGL :::::.::::.:::::....:.::::::::.::::.:.::.:...::::::.::::.::: NP_001 MKHENILQFIGAEKRGTSVDVDLWLITAFHEKGSLSDFLKANVVSWNELCHIAETMARGL 250 260 270 280 290 300 300 310 320 330 340 350 pF1KE0 SYLHEDVPWCRGEGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRFEPGKPPGDTHGQ .:::::.: . .::::.:.:::.::::::::..::: .::::::..:: :: :::::: NP_001 AYLHEDIPGLK-DGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGDTHGQ 310 320 330 340 350 360 370 380 390 400 410 pF1KE0 VGTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELVSRCKAADGPVDEYMLPFEEEI ::::::::::::::::::::::::::::::::::::::.::: ::::::::::::::::: NP_001 VGTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELASRCTAADGPVDEYMLPFEEEI 360 370 380 390 400 410 420 430 440 450 460 470 pF1KE0 GQHPSLEELQEVVVHKKMRPTIKDHWLKHPGLAQLCVTIEECWDHDAEARLSAGCVEERV :::::::..:::::::: ::...:.: :: :.:.:: ::::::::::::::::::: ::. NP_001 GQHPSLEDMQEVVVHKKKRPVLRDYWQKHAGMAMLCETIEECWDHDAEARLSAGCVGERI 420 430 440 450 460 470 480 490 500 510 pF1KE0 SLIRRSVNGTTSDCLVSLVTSVTNVDLPPKESSI . ..: .: :.. .:..:: :::::.::::::. NP_001 TQMQRLTNIITTEDIVTVVTMVTNVDFPPKESSL 480 490 500 510 >>NP_001265509 (OMIM: 102581) activin receptor type-2A i (405 aa) initn: 1885 init1: 1095 opt: 2038 Z-score: 855.9 bits: 167.6 E(85289): 6.2e-41 Smith-Waterman score: 2038; 70.1% identity (88.6% similar) in 405 aa overlap (109-512:2-405) 80 90 100 110 120 130 pF1KE0 LDDFNCYDRQECVATEENPQVYFCCCEGNFCNERFTHLPEAGGPEVTYEPPPTAPTLLTV :::.:...:: . : .: : .. NP_001 MCNEKFSYFPEMEVTQPTSNPVTPKPPYYNI 10 20 30 140 150 160 170 180 190 pF1KE0 LAYSLLPIGGLSLIVLLAFWMYRHRKPPYGHVDIH-EDPGPPPPSPLVGLKPLQLLEIKA : :::.:. .. ::. :::.:::.: : : . .::::::::::.:::::::::.:: NP_001 LLYSLVPLMLIAGIVICAFWVYRHHKMAYPPVLVPTQDPGPPPPSPLLGLKPLQLLEVKA 40 50 60 70 80 90 200 210 220 230 240 250 pF1KE0 RGRFGCVWKAQLMNDFVAVKIFPLQDKQSWQSEREIFSTPGMKHENLLQFIAAEKRGSNL ::::::::::::.:..:::::::.:::::::.: :..: :::::::.::::.:::::... NP_001 RGRFGCVWKAQLLNEYVAVKIFPIQDKQSWQNEYEVYSLPGMKHENILQFIGAEKRGTSV 100 110 120 130 140 150 260 270 280 290 300 310 pF1KE0 EVELWLITAFHDKGSLTDYLKGNIITWNELCHVAETMSRGLSYLHEDVPWCRGEGHKPSI .:.::::::::.::::.:.::.:...::::::.::::.:::.:::::.: . .::::.: NP_001 DVDLWLITAFHEKGSLSDFLKANVVSWNELCHIAETMARGLAYLHEDIPGLK-DGHKPAI 160 170 180 190 200 210 320 330 340 350 360 370 pF1KE0 AHRDFKSKNVLLKSDLTAVLADFGLAVRFEPGKPPGDTHGQVGTRRYMAPEVLEGAINFQ .:::.::::::::..::: .::::::..:: :: ::::::::::::::::::::::::: NP_001 SHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGDTHGQVGTRRYMAPEVLEGAINFQ 220 230 240 250 260 270 380 390 400 410 420 430 pF1KE0 RDAFLRIDMYAMGLVLWELVSRCKAADGPVDEYMLPFEEEIGQHPSLEELQEVVVHKKMR :::::::::::::::::::.::: ::::::::::::::::::::::::..:::::::: : NP_001 RDAFLRIDMYAMGLVLWELASRCTAADGPVDEYMLPFEEEIGQHPSLEDMQEVVVHKKKR 280 290 300 310 320 330 440 450 460 470 480 490 pF1KE0 PTIKDHWLKHPGLAQLCVTIEECWDHDAEARLSAGCVEERVSLIRRSVNGTTSDCLVSLV :...:.: :: :.:.:: ::::::::::::::::::: ::.. ..: .: :.. .:..: NP_001 PVLRDYWQKHAGMAMLCETIEECWDHDAEARLSAGCVGERITQMQRLTNIITTEDIVTVV 340 350 360 370 380 390 500 510 pF1KE0 TSVTNVDLPPKESSI : :::::.::::::. NP_001 TMVTNVDFPPKESSL 400 >>XP_011532347 (OMIM: 133239,190182,610168,614331) PREDI (532 aa) initn: 837 init1: 584 opt: 919 Z-score: 403.7 bits: 84.3 E(85289): 9.5e-16 Smith-Waterman score: 973; 37.6% identity (62.7% similar) in 482 aa overlap (41-479:34-504) 20 30 40 50 60 pF1KE0 LWGSLCAGSGRGEAETRECIYYNANWELERTNQSGLERCEGEQDKRLHCYASWRNSSG-- .: : :: :. : : ::... XP_011 TDNNGAVKFPQLCKFCDVRFSTCDNQKSCMSNCSITSICEKPQEV---CVAVWRKNDENI 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 TIELVKKGCWLD--DFNCYD--RQECVATEEN-P-QVYF-CCCEGNFCNERFTHLPEAGG :.: : . : :: : .:. :.. : ...: : : .. ::. . . XP_011 TLETVCHDPKLPYHDFILEDAASPKCIMKEKKKPGETFFMCSCSSDECNDNIIF-----S 70 80 90 100 110 130 140 150 160 pF1KE0 PEVTYEPPPTAPTLLTVLAYSLLPIGGLSLIVLLAFWMYR-HRKPPYG------------ : . : ... : . :::: :... :.. :. :: .:. . XP_011 EEYNTSNPDLLLVIFQVTGISLLPPLGVAISVIIIFYCYRVNRQQKLSSTWETGKTRKLM 120 130 140 150 160 170 170 180 190 200 210 pF1KE0 ----HVDI-HEDPGPPPPSPLVG-------LKPLQLLEIKARGRFGCVWKAQLMNDF--- : : :: : .. : :..: . ..:::. :.::.: .. XP_011 EFSEHCAIILEDDRSDISSTCANNINHNTELLPIELDTLVGKGRFAEVYKAKLKQNTSEQ 180 190 200 210 220 230 220 230 240 250 260 270 pF1KE0 ---VAVKIFPLQDKQSWQSEREIFSTPGMKHENLLQFIAAEKRGSNLEVELWLITAFHDK ::::::: .. ::..:..::: ..::::.:::..::.: ..: . ::::::: : XP_011 FETVAVKIFPYEEYASWKTEKDIFSDINLKHENILQFLTAEERKTELGKQYWLITAFHAK 240 250 260 270 280 290 280 290 300 310 320 330 pF1KE0 GSLTDYLKGNIITWNELCHVAETMSRGLSYLHEDVPWCRGEGHKPSIAHRDFKSKNVLLK :.: .:: ..:.:..: ... ...::...:: : : :. . : :.:::.::.:.:.: XP_011 GNLQEYLTRHVISWEDLRKLGSSLARGIAHLHSDHTPC-GRPKMP-IVHRDLKSSNILVK 300 310 320 330 340 350 340 350 360 370 380 pF1KE0 SDLTAVLADFGLAVRFEPGKPPGD--THGQVGTRRYMAPEVLEGAINFQR-DAFLRIDMY .::: : ::::..:..: : . ::::: :::::::::. .:.. ..: . :.: XP_011 NDLTCCLCDFGLSLRLDPTLSVDDLANSGQVGTARYMAPEVLESRMNLENVESFKQTDVY 360 370 380 390 400 410 390 400 410 420 430 440 pF1KE0 AMGLVLWELVSRCKAADGPVDEYMLPFEEEIGQHPSLEELQEVVVHKKMRPTIKDHWLKH .:.:::::..:::.:. : : .: :: .. .:: .: ... :.. . :: : . ::.: XP_011 SMALVLWEMTSRCNAV-GEVKDYEPPFGSKVREHPCVESMKDNVLRDRGRPEIPSFWLNH 420 430 440 450 460 470 450 460 470 480 490 500 pF1KE0 PGLAQLCVTIEECWDHDAEARLSAGCVEERVSLIRRSVNGTTSDCLVSLVTSVTNVDLPP :. ..: :. :::::: ::::.: :: :: : XP_011 QGIQMVCETLTECWDHDPEARLTAQCVAERFSELEHLDRLSGRSCSEEKIPEDGSLNTTK 480 490 500 510 520 530 510 pF1KE0 KESSI >>XP_016862595 (OMIM: 133239,190182,610168,614331) PREDI (532 aa) initn: 837 init1: 584 opt: 919 Z-score: 403.7 bits: 84.3 E(85289): 9.5e-16 Smith-Waterman score: 973; 37.6% identity (62.7% similar) in 482 aa overlap (41-479:34-504) 20 30 40 50 60 pF1KE0 LWGSLCAGSGRGEAETRECIYYNANWELERTNQSGLERCEGEQDKRLHCYASWRNSSG-- .: : :: :. : : ::... XP_016 TDNNGAVKFPQLCKFCDVRFSTCDNQKSCMSNCSITSICEKPQEV---CVAVWRKNDENI 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 TIELVKKGCWLD--DFNCYD--RQECVATEEN-P-QVYF-CCCEGNFCNERFTHLPEAGG :.: : . : :: : .:. :.. : ...: : : .. ::. . . XP_016 TLETVCHDPKLPYHDFILEDAASPKCIMKEKKKPGETFFMCSCSSDECNDNIIF-----S 70 80 90 100 110 130 140 150 160 pF1KE0 PEVTYEPPPTAPTLLTVLAYSLLPIGGLSLIVLLAFWMYR-HRKPPYG------------ : . : ... : . :::: :... :.. :. :: .:. . XP_016 EEYNTSNPDLLLVIFQVTGISLLPPLGVAISVIIIFYCYRVNRQQKLSSTWETGKTRKLM 120 130 140 150 160 170 170 180 190 200 210 pF1KE0 ----HVDI-HEDPGPPPPSPLVG-------LKPLQLLEIKARGRFGCVWKAQLMNDF--- : : :: : .. : :..: . ..:::. :.::.: .. XP_016 EFSEHCAIILEDDRSDISSTCANNINHNTELLPIELDTLVGKGRFAEVYKAKLKQNTSEQ 180 190 200 210 220 230 220 230 240 250 260 270 pF1KE0 ---VAVKIFPLQDKQSWQSEREIFSTPGMKHENLLQFIAAEKRGSNLEVELWLITAFHDK ::::::: .. ::..:..::: ..::::.:::..::.: ..: . ::::::: : XP_016 FETVAVKIFPYEEYASWKTEKDIFSDINLKHENILQFLTAEERKTELGKQYWLITAFHAK 240 250 260 270 280 290 280 290 300 310 320 330 pF1KE0 GSLTDYLKGNIITWNELCHVAETMSRGLSYLHEDVPWCRGEGHKPSIAHRDFKSKNVLLK :.: .:: ..:.:..: ... ...::...:: : : :. . : :.:::.::.:.:.: XP_016 GNLQEYLTRHVISWEDLRKLGSSLARGIAHLHSDHTPC-GRPKMP-IVHRDLKSSNILVK 300 310 320 330 340 350 340 350 360 370 380 pF1KE0 SDLTAVLADFGLAVRFEPGKPPGD--THGQVGTRRYMAPEVLEGAINFQR-DAFLRIDMY .::: : ::::..:..: : . ::::: :::::::::. .:.. ..: . :.: XP_016 NDLTCCLCDFGLSLRLDPTLSVDDLANSGQVGTARYMAPEVLESRMNLENVESFKQTDVY 360 370 380 390 400 410 390 400 410 420 430 440 pF1KE0 AMGLVLWELVSRCKAADGPVDEYMLPFEEEIGQHPSLEELQEVVVHKKMRPTIKDHWLKH .:.:::::..:::.:. : : .: :: .. .:: .: ... :.. . :: : . ::.: XP_016 SMALVLWEMTSRCNAV-GEVKDYEPPFGSKVREHPCVESMKDNVLRDRGRPEIPSFWLNH 420 430 440 450 460 470 450 460 470 480 490 500 pF1KE0 PGLAQLCVTIEECWDHDAEARLSAGCVEERVSLIRRSVNGTTSDCLVSLVTSVTNVDLPP :. ..: :. :::::: ::::.: :: :: : XP_016 QGIQMVCETLTECWDHDPEARLTAQCVAERFSELEHLDRLSGRSCSEEKIPEDGSLNTTK 480 490 500 510 520 530 510 pF1KE0 KESSI 512 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Mon Nov 7 15:19:00 2016 done: Mon Nov 7 15:19:02 2016 Total Scan time: 10.730 Total Display time: 0.090 Function used was FASTA [36.3.4 Apr, 2011]