Result of FASTA (omim) for
pFN21AE1043
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE1043, 470 aa
1>>>pF1KE1043 470 - 470 aa - 470 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 7.2198+/-0.000452; mu= 11.5886+/- 0.028
mean_var=372.2829+/-95.573, 0's: 0 Z-trim(118.1): 138 B-trim: 0 in 0/50
Lambda= 0.066472
statistics sampled from 30575 (30724) to 30575 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.706), E-opt: 0.2 (0.36), width: 16
Scan time: 10.070
The best scores are: opt bits E(85289)
NP_004286 (OMIM: 602464) TNF receptor-associated f ( 470) 3397 340.5 6.1e-93
XP_011523806 (OMIM: 602464) PREDICTED: TNF recepto ( 477) 3373 338.2 3e-92
XP_011523808 (OMIM: 602464) PREDICTED: TNF recepto ( 454) 3039 306.1 1.3e-82
XP_011523807 (OMIM: 602464) PREDICTED: TNF recepto ( 461) 3015 303.8 6.5e-82
XP_011523809 (OMIM: 602464) PREDICTED: TNF recepto ( 352) 2502 254.4 3.7e-67
XP_011523810 (OMIM: 602464) PREDICTED: TNF recepto ( 352) 2502 254.4 3.7e-67
NP_004611 (OMIM: 602355) TNF receptor-associated f ( 522) 641 76.2 2.3e-13
NP_665802 (OMIM: 602355) TNF receptor-associated f ( 522) 641 76.2 2.3e-13
XP_011517280 (OMIM: 601895) PREDICTED: TNF recepto ( 501) 416 54.6 7.2e-07
NP_066961 (OMIM: 601895) TNF receptor-associated f ( 501) 416 54.6 7.2e-07
XP_011517278 (OMIM: 601895) PREDICTED: TNF recepto ( 501) 416 54.6 7.2e-07
XP_016870584 (OMIM: 601895) PREDICTED: TNF recepto ( 501) 416 54.6 7.2e-07
XP_011517276 (OMIM: 601895) PREDICTED: TNF recepto ( 501) 416 54.6 7.2e-07
XP_011517279 (OMIM: 601895) PREDICTED: TNF recepto ( 501) 416 54.6 7.2e-07
XP_011517277 (OMIM: 601895) PREDICTED: TNF recepto ( 501) 416 54.6 7.2e-07
XP_016870583 (OMIM: 601895) PREDICTED: TNF recepto ( 533) 416 54.7 7.4e-07
XP_011517275 (OMIM: 601895) PREDICTED: TNF recepto ( 556) 416 54.7 7.6e-07
XP_016877109 (OMIM: 601896,614849) PREDICTED: TNF ( 292) 388 51.5 3.6e-06
NP_663778 (OMIM: 601896,614849) TNF receptor-assoc ( 543) 382 51.4 7.2e-06
XP_016877108 (OMIM: 601896,614849) PREDICTED: TNF ( 543) 382 51.4 7.2e-06
NP_001177876 (OMIM: 601711) TNF receptor-associate ( 294) 374 50.2 9.1e-06
NP_005649 (OMIM: 601711) TNF receptor-associated f ( 416) 374 50.5 1.1e-05
NP_001177874 (OMIM: 601711) TNF receptor-associate ( 416) 374 50.5 1.1e-05
XP_011535420 (OMIM: 601896,614849) PREDICTED: TNF ( 485) 373 50.5 1.2e-05
NP_001186356 (OMIM: 601896,614849) TNF receptor-as ( 485) 373 50.5 1.2e-05
XP_011535419 (OMIM: 601896,614849) PREDICTED: TNF ( 512) 373 50.5 1.3e-05
XP_011535418 (OMIM: 601896,614849) PREDICTED: TNF ( 516) 373 50.5 1.3e-05
XP_016873709 (OMIM: 602355) PREDICTED: TNF recepto ( 324) 369 49.8 1.3e-05
XP_016877107 (OMIM: 601896,614849) PREDICTED: TNF ( 568) 373 50.6 1.3e-05
XP_016877106 (OMIM: 601896,614849) PREDICTED: TNF ( 568) 373 50.6 1.3e-05
NP_003291 (OMIM: 601896,614849) TNF receptor-assoc ( 568) 373 50.6 1.3e-05
NP_663777 (OMIM: 601896,614849) TNF receptor-assoc ( 568) 373 50.6 1.3e-05
NP_665702 (OMIM: 602356) TNF receptor-associated f ( 557) 370 50.3 1.6e-05
NP_004610 (OMIM: 602356) TNF receptor-associated f ( 557) 370 50.3 1.6e-05
NP_001029082 (OMIM: 602356) TNF receptor-associate ( 557) 370 50.3 1.6e-05
XP_016857710 (OMIM: 602356) PREDICTED: TNF recepto ( 557) 370 50.3 1.6e-05
NP_001306136 (OMIM: 602356) TNF receptor-associate ( 568) 370 50.3 1.6e-05
XP_011508261 (OMIM: 602356) PREDICTED: TNF recepto ( 568) 370 50.3 1.6e-05
XP_011508262 (OMIM: 602356) PREDICTED: TNF recepto ( 568) 370 50.3 1.6e-05
XP_011508259 (OMIM: 602356) PREDICTED: TNF recepto ( 631) 370 50.4 1.7e-05
>>NP_004286 (OMIM: 602464) TNF receptor-associated facto (470 aa)
initn: 3397 init1: 3397 opt: 3397 Z-score: 1789.5 bits: 340.5 E(85289): 6.1e-93
Smith-Waterman score: 3397; 100.0% identity (100.0% similar) in 470 aa overlap (1-470:1-470)
10 20 30 40 50 60
pF1KE1 MPGFDYKFLEKPKRRLLCPLCGKPMREPVQVSTCGHRFCDTCLQEFLSEGVFKCPEDQLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 MPGFDYKFLEKPKRRLLCPLCGKPMREPVQVSTCGHRFCDTCLQEFLSEGVFKCPEDQLP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 LDYAKIYPDPELEVQVLGLPIRCIHSEEGCRWSGPLRHLQGHLNTCSFNVIPCPNRCPMK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 LDYAKIYPDPELEVQVLGLPIRCIHSEEGCRWSGPLRHLQGHLNTCSFNVIPCPNRCPMK
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 LSRRDLPAHLQHDCPKRRLKCEFCGCDFSGEAYESHEGMCPQESVYCENKCGARMMRRLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 LSRRDLPAHLQHDCPKRRLKCEFCGCDFSGEAYESHEGMCPQESVYCENKCGARMMRRLL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE1 AQHATSECPKRTQPCTYCTKEFVFDTIQSHQYQCPRLPVACPNQCGVGTVAREDLPGHLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 AQHATSECPKRTQPCTYCTKEFVFDTIQSHQYQCPRLPVACPNQCGVGTVAREDLPGHLK
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE1 DSCNTALVLCPFKDSGCKHRCPKLAMARHVEESVKPHLAMMCALVSRQRQELQELRRELE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 DSCNTALVLCPFKDSGCKHRCPKLAMARHVEESVKPHLAMMCALVSRQRQELQELRRELE
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE1 ELSVGSDGVLIWKIGSYGRRLQEAKAKPNLECFSPAFYTHKYGYKLQVSAFLNGNGSGEG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 ELSVGSDGVLIWKIGSYGRRLQEAKAKPNLECFSPAFYTHKYGYKLQVSAFLNGNGSGEG
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE1 THLSLYIRVLPGAFDNLLEWPFARRVTFSLLDQSDPGLAKPQHVTETFHPDPNWKNFQKP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 THLSLYIRVLPGAFDNLLEWPFARRVTFSLLDQSDPGLAKPQHVTETFHPDPNWKNFQKP
370 380 390 400 410 420
430 440 450 460 470
pF1KE1 GTWRGSLDESSLGFGYPKFISHQDIRKRNYVRDDAVFIRAAVELPRKILS
::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 GTWRGSLDESSLGFGYPKFISHQDIRKRNYVRDDAVFIRAAVELPRKILS
430 440 450 460 470
>>XP_011523806 (OMIM: 602464) PREDICTED: TNF receptor-as (477 aa)
initn: 2928 init1: 2928 opt: 3373 Z-score: 1777.0 bits: 338.2 E(85289): 3e-92
Smith-Waterman score: 3373; 98.5% identity (98.5% similar) in 477 aa overlap (1-470:1-477)
10 20 30 40 50 60
pF1KE1 MPGFDYKFLEKPKRRLLCPLCGKPMREPVQVSTCGHRFCDTCLQEFLSEGVFKCPEDQLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MPGFDYKFLEKPKRRLLCPLCGKPMREPVQVSTCGHRFCDTCLQEFLSEGVFKCPEDQLP
10 20 30 40 50 60
70 80 90 100 110
pF1KE1 LDYAK-------IYPDPELEVQVLGLPIRCIHSEEGCRWSGPLRHLQGHLNTCSFNVIPC
::::: ::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LDYAKFPHPYPQIYPDPELEVQVLGLPIRCIHSEEGCRWSGPLRHLQGHLNTCSFNVIPC
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE1 PNRCPMKLSRRDLPAHLQHDCPKRRLKCEFCGCDFSGEAYESHEGMCPQESVYCENKCGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PNRCPMKLSRRDLPAHLQHDCPKRRLKCEFCGCDFSGEAYESHEGMCPQESVYCENKCGA
130 140 150 160 170 180
180 190 200 210 220 230
pF1KE1 RMMRRLLAQHATSECPKRTQPCTYCTKEFVFDTIQSHQYQCPRLPVACPNQCGVGTVARE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RMMRRLLAQHATSECPKRTQPCTYCTKEFVFDTIQSHQYQCPRLPVACPNQCGVGTVARE
190 200 210 220 230 240
240 250 260 270 280 290
pF1KE1 DLPGHLKDSCNTALVLCPFKDSGCKHRCPKLAMARHVEESVKPHLAMMCALVSRQRQELQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DLPGHLKDSCNTALVLCPFKDSGCKHRCPKLAMARHVEESVKPHLAMMCALVSRQRQELQ
250 260 270 280 290 300
300 310 320 330 340 350
pF1KE1 ELRRELEELSVGSDGVLIWKIGSYGRRLQEAKAKPNLECFSPAFYTHKYGYKLQVSAFLN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ELRRELEELSVGSDGVLIWKIGSYGRRLQEAKAKPNLECFSPAFYTHKYGYKLQVSAFLN
310 320 330 340 350 360
360 370 380 390 400 410
pF1KE1 GNGSGEGTHLSLYIRVLPGAFDNLLEWPFARRVTFSLLDQSDPGLAKPQHVTETFHPDPN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GNGSGEGTHLSLYIRVLPGAFDNLLEWPFARRVTFSLLDQSDPGLAKPQHVTETFHPDPN
370 380 390 400 410 420
420 430 440 450 460 470
pF1KE1 WKNFQKPGTWRGSLDESSLGFGYPKFISHQDIRKRNYVRDDAVFIRAAVELPRKILS
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 WKNFQKPGTWRGSLDESSLGFGYPKFISHQDIRKRNYVRDDAVFIRAAVELPRKILS
430 440 450 460 470
>>XP_011523808 (OMIM: 602464) PREDICTED: TNF receptor-as (454 aa)
initn: 3039 init1: 3039 opt: 3039 Z-score: 1604.1 bits: 306.1 E(85289): 1.3e-82
Smith-Waterman score: 3039; 100.0% identity (100.0% similar) in 423 aa overlap (48-470:32-454)
20 30 40 50 60 70
pF1KE1 CPLCGKPMREPVQVSTCGHRFCDTCLQEFLSEGVFKCPEDQLPLDYAKIYPDPELEVQVL
::::::::::::::::::::::::::::::
XP_011 PGMCDWPWLGSARACRQKEACQQAPWVLTASEGVFKCPEDQLPLDYAKIYPDPELEVQVL
10 20 30 40 50 60
80 90 100 110 120 130
pF1KE1 GLPIRCIHSEEGCRWSGPLRHLQGHLNTCSFNVIPCPNRCPMKLSRRDLPAHLQHDCPKR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GLPIRCIHSEEGCRWSGPLRHLQGHLNTCSFNVIPCPNRCPMKLSRRDLPAHLQHDCPKR
70 80 90 100 110 120
140 150 160 170 180 190
pF1KE1 RLKCEFCGCDFSGEAYESHEGMCPQESVYCENKCGARMMRRLLAQHATSECPKRTQPCTY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RLKCEFCGCDFSGEAYESHEGMCPQESVYCENKCGARMMRRLLAQHATSECPKRTQPCTY
130 140 150 160 170 180
200 210 220 230 240 250
pF1KE1 CTKEFVFDTIQSHQYQCPRLPVACPNQCGVGTVAREDLPGHLKDSCNTALVLCPFKDSGC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CTKEFVFDTIQSHQYQCPRLPVACPNQCGVGTVAREDLPGHLKDSCNTALVLCPFKDSGC
190 200 210 220 230 240
260 270 280 290 300 310
pF1KE1 KHRCPKLAMARHVEESVKPHLAMMCALVSRQRQELQELRRELEELSVGSDGVLIWKIGSY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KHRCPKLAMARHVEESVKPHLAMMCALVSRQRQELQELRRELEELSVGSDGVLIWKIGSY
250 260 270 280 290 300
320 330 340 350 360 370
pF1KE1 GRRLQEAKAKPNLECFSPAFYTHKYGYKLQVSAFLNGNGSGEGTHLSLYIRVLPGAFDNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GRRLQEAKAKPNLECFSPAFYTHKYGYKLQVSAFLNGNGSGEGTHLSLYIRVLPGAFDNL
310 320 330 340 350 360
380 390 400 410 420 430
pF1KE1 LEWPFARRVTFSLLDQSDPGLAKPQHVTETFHPDPNWKNFQKPGTWRGSLDESSLGFGYP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LEWPFARRVTFSLLDQSDPGLAKPQHVTETFHPDPNWKNFQKPGTWRGSLDESSLGFGYP
370 380 390 400 410 420
440 450 460 470
pF1KE1 KFISHQDIRKRNYVRDDAVFIRAAVELPRKILS
:::::::::::::::::::::::::::::::::
XP_011 KFISHQDIRKRNYVRDDAVFIRAAVELPRKILS
430 440 450
>>XP_011523807 (OMIM: 602464) PREDICTED: TNF receptor-as (461 aa)
initn: 2928 init1: 2928 opt: 3015 Z-score: 1591.6 bits: 303.8 E(85289): 6.5e-82
Smith-Waterman score: 3015; 98.4% identity (98.4% similar) in 430 aa overlap (48-470:32-461)
20 30 40 50 60 70
pF1KE1 CPLCGKPMREPVQVSTCGHRFCDTCLQEFLSEGVFKCPEDQLPLDYAK-------IYPDP
:::::::::::::::::: :::::
XP_011 PGMCDWPWLGSARACRQKEACQQAPWVLTASEGVFKCPEDQLPLDYAKFPHPYPQIYPDP
10 20 30 40 50 60
80 90 100 110 120 130
pF1KE1 ELEVQVLGLPIRCIHSEEGCRWSGPLRHLQGHLNTCSFNVIPCPNRCPMKLSRRDLPAHL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ELEVQVLGLPIRCIHSEEGCRWSGPLRHLQGHLNTCSFNVIPCPNRCPMKLSRRDLPAHL
70 80 90 100 110 120
140 150 160 170 180 190
pF1KE1 QHDCPKRRLKCEFCGCDFSGEAYESHEGMCPQESVYCENKCGARMMRRLLAQHATSECPK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QHDCPKRRLKCEFCGCDFSGEAYESHEGMCPQESVYCENKCGARMMRRLLAQHATSECPK
130 140 150 160 170 180
200 210 220 230 240 250
pF1KE1 RTQPCTYCTKEFVFDTIQSHQYQCPRLPVACPNQCGVGTVAREDLPGHLKDSCNTALVLC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RTQPCTYCTKEFVFDTIQSHQYQCPRLPVACPNQCGVGTVAREDLPGHLKDSCNTALVLC
190 200 210 220 230 240
260 270 280 290 300 310
pF1KE1 PFKDSGCKHRCPKLAMARHVEESVKPHLAMMCALVSRQRQELQELRRELEELSVGSDGVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PFKDSGCKHRCPKLAMARHVEESVKPHLAMMCALVSRQRQELQELRRELEELSVGSDGVL
250 260 270 280 290 300
320 330 340 350 360 370
pF1KE1 IWKIGSYGRRLQEAKAKPNLECFSPAFYTHKYGYKLQVSAFLNGNGSGEGTHLSLYIRVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IWKIGSYGRRLQEAKAKPNLECFSPAFYTHKYGYKLQVSAFLNGNGSGEGTHLSLYIRVL
310 320 330 340 350 360
380 390 400 410 420 430
pF1KE1 PGAFDNLLEWPFARRVTFSLLDQSDPGLAKPQHVTETFHPDPNWKNFQKPGTWRGSLDES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PGAFDNLLEWPFARRVTFSLLDQSDPGLAKPQHVTETFHPDPNWKNFQKPGTWRGSLDES
370 380 390 400 410 420
440 450 460 470
pF1KE1 SLGFGYPKFISHQDIRKRNYVRDDAVFIRAAVELPRKILS
::::::::::::::::::::::::::::::::::::::::
XP_011 SLGFGYPKFISHQDIRKRNYVRDDAVFIRAAVELPRKILS
430 440 450 460
>>XP_011523809 (OMIM: 602464) PREDICTED: TNF receptor-as (352 aa)
initn: 2502 init1: 2502 opt: 2502 Z-score: 1326.7 bits: 254.4 E(85289): 3.7e-67
Smith-Waterman score: 2502; 100.0% identity (100.0% similar) in 352 aa overlap (119-470:1-352)
90 100 110 120 130 140
pF1KE1 GCRWSGPLRHLQGHLNTCSFNVIPCPNRCPMKLSRRDLPAHLQHDCPKRRLKCEFCGCDF
::::::::::::::::::::::::::::::
XP_011 MKLSRRDLPAHLQHDCPKRRLKCEFCGCDF
10 20 30
150 160 170 180 190 200
pF1KE1 SGEAYESHEGMCPQESVYCENKCGARMMRRLLAQHATSECPKRTQPCTYCTKEFVFDTIQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SGEAYESHEGMCPQESVYCENKCGARMMRRLLAQHATSECPKRTQPCTYCTKEFVFDTIQ
40 50 60 70 80 90
210 220 230 240 250 260
pF1KE1 SHQYQCPRLPVACPNQCGVGTVAREDLPGHLKDSCNTALVLCPFKDSGCKHRCPKLAMAR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SHQYQCPRLPVACPNQCGVGTVAREDLPGHLKDSCNTALVLCPFKDSGCKHRCPKLAMAR
100 110 120 130 140 150
270 280 290 300 310 320
pF1KE1 HVEESVKPHLAMMCALVSRQRQELQELRRELEELSVGSDGVLIWKIGSYGRRLQEAKAKP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HVEESVKPHLAMMCALVSRQRQELQELRRELEELSVGSDGVLIWKIGSYGRRLQEAKAKP
160 170 180 190 200 210
330 340 350 360 370 380
pF1KE1 NLECFSPAFYTHKYGYKLQVSAFLNGNGSGEGTHLSLYIRVLPGAFDNLLEWPFARRVTF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NLECFSPAFYTHKYGYKLQVSAFLNGNGSGEGTHLSLYIRVLPGAFDNLLEWPFARRVTF
220 230 240 250 260 270
390 400 410 420 430 440
pF1KE1 SLLDQSDPGLAKPQHVTETFHPDPNWKNFQKPGTWRGSLDESSLGFGYPKFISHQDIRKR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SLLDQSDPGLAKPQHVTETFHPDPNWKNFQKPGTWRGSLDESSLGFGYPKFISHQDIRKR
280 290 300 310 320 330
450 460 470
pF1KE1 NYVRDDAVFIRAAVELPRKILS
::::::::::::::::::::::
XP_011 NYVRDDAVFIRAAVELPRKILS
340 350
>>XP_011523810 (OMIM: 602464) PREDICTED: TNF receptor-as (352 aa)
initn: 2502 init1: 2502 opt: 2502 Z-score: 1326.7 bits: 254.4 E(85289): 3.7e-67
Smith-Waterman score: 2502; 100.0% identity (100.0% similar) in 352 aa overlap (119-470:1-352)
90 100 110 120 130 140
pF1KE1 GCRWSGPLRHLQGHLNTCSFNVIPCPNRCPMKLSRRDLPAHLQHDCPKRRLKCEFCGCDF
::::::::::::::::::::::::::::::
XP_011 MKLSRRDLPAHLQHDCPKRRLKCEFCGCDF
10 20 30
150 160 170 180 190 200
pF1KE1 SGEAYESHEGMCPQESVYCENKCGARMMRRLLAQHATSECPKRTQPCTYCTKEFVFDTIQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SGEAYESHEGMCPQESVYCENKCGARMMRRLLAQHATSECPKRTQPCTYCTKEFVFDTIQ
40 50 60 70 80 90
210 220 230 240 250 260
pF1KE1 SHQYQCPRLPVACPNQCGVGTVAREDLPGHLKDSCNTALVLCPFKDSGCKHRCPKLAMAR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SHQYQCPRLPVACPNQCGVGTVAREDLPGHLKDSCNTALVLCPFKDSGCKHRCPKLAMAR
100 110 120 130 140 150
270 280 290 300 310 320
pF1KE1 HVEESVKPHLAMMCALVSRQRQELQELRRELEELSVGSDGVLIWKIGSYGRRLQEAKAKP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HVEESVKPHLAMMCALVSRQRQELQELRRELEELSVGSDGVLIWKIGSYGRRLQEAKAKP
160 170 180 190 200 210
330 340 350 360 370 380
pF1KE1 NLECFSPAFYTHKYGYKLQVSAFLNGNGSGEGTHLSLYIRVLPGAFDNLLEWPFARRVTF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NLECFSPAFYTHKYGYKLQVSAFLNGNGSGEGTHLSLYIRVLPGAFDNLLEWPFARRVTF
220 230 240 250 260 270
390 400 410 420 430 440
pF1KE1 SLLDQSDPGLAKPQHVTETFHPDPNWKNFQKPGTWRGSLDESSLGFGYPKFISHQDIRKR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SLLDQSDPGLAKPQHVTETFHPDPNWKNFQKPGTWRGSLDESSLGFGYPKFISHQDIRKR
280 290 300 310 320 330
450 460 470
pF1KE1 NYVRDDAVFIRAAVELPRKILS
::::::::::::::::::::::
XP_011 NYVRDDAVFIRAAVELPRKILS
340 350
>>NP_004611 (OMIM: 602355) TNF receptor-associated facto (522 aa)
initn: 711 init1: 143 opt: 641 Z-score: 360.8 bits: 76.2 E(85289): 2.3e-13
Smith-Waterman score: 746; 26.7% identity (58.0% similar) in 469 aa overlap (1-462:53-499)
10 20 30
pF1KE1 MPGFDYKFLEKPKRRLLCPLCGKPMREPVQ
. :.: .: . . ::.: .:: ::
NP_004 MASSCSAVTKDDSVGGTASTGNLSSSFMEEIQGYDVEFDPPLESKYECPICLMALREAVQ
30 40 50 60 70 80
40 50 60 70 80 90
pF1KE1 VSTCGHRFCDTCLQEFLSEGVFKCPEDQLPLDYAKIYPDPELEVQVLGLPIRCIHSEEGC
. :::::: .:. . . .. ::: :. : ...:: . ..:.: ..: .:::
NP_004 -TPCGHRFCKACIIKSIRDAGHKCPVDNEILLENQLFPDNFAKREILSLMVKC--PNEGC
90 100 110 120 130
100 110 120 130 140 150
pF1KE1 RWSGPLRHLQGHLNTCSFNVIPCPNRCPMKLSRRDLPAHLQHDCPKRRLKCEFCGCDFSG
. ::::. : : : .. :: .: ... . :. .:::.:...:. :. ...
NP_004 LHKMELRHLEDHQAHCEFALMDCP-QCQRPFQKFHINIHILKDCPRRQVSCDNCAASMAF
140 150 160 170 180 190
160 170 180 190 200
pF1KE1 EAYESHEGMCPQESVYCENKCGARMMRRLLAQHATSECPKRTQPCTY----CTKEFVFDT
: : :. :: .: :: :.. ..:. . .: .:: :::. : ... .
NP_004 EDKEIHDQNCPLANVICEY-CNTILIREQMPNHYDLDCPTAPIPCTFSTFGCHEKMQRNH
200 210 220 230 240 250
210 220 230 240 250 260
pF1KE1 IQSHQYQCPRLPVACPNQCGVGTVAREDLPGHLKDSCNTALVLCPFKDSGCKHRCP-KLA
. : . . . : .: ... :.... : :... :. .:.
NP_004 LARHLQENTQSHMRMLAQ-AVHSLSVIPDSGYISEVRN-------FQET--IHQLEGRLV
260 270 280 290 300
270 280 290 300 310 320
pF1KE1 MARHVEESVKPHLAMMCALVSRQRQELQELRRELEELSVGS-DGVLIWKIGSYGRRLQEA
: . . .. . ::. .. .. :. .. :. . . .:. :::::..: .:.
NP_004 RQDHQIRELTAKMETQSMYVSELKRTIRTLEDKVAEIEAQQCNGIYIWKIGNFGMHLKCQ
310 320 330 340 350 360
330 340 350 360 370 380
pF1KE1 KAKPNLECFSPAFYTHKYGYKLQVSAFLN-GNGSGEGTHLSLYIRVLPGAFDNLLEWPFA
. . . ::.::: : :::: . :. ... ....::..... : .:. : :::
NP_004 EEEKPVVIHSPGFYTGKPGYKLCMRLHLQLPTAQRCANYISLFVHTMQGEYDSHLPWPFQ
370 380 390 400 410 420
390 400 410 420 430 440
pF1KE1 RRVTFSLLDQSDPGLAKPQHVTETFHPDPNWKNFQKPGTWRGSLDESSLGFGYPKFISHQ
. ...::::. . . .: : . :. ::.: .. .. :::: :. .
NP_004 GTIRLTILDQSEAPV-RQNH-EEIMDAKPELLAFQRP-----TIPRNPKGFGYVTFMHLE
430 440 450 460 470 480
450 460 470
pF1KE1 DIRKRNYVRDDAVFIRAAVELPRKILS
.:.:....::....: :
NP_004 ALRQRTFIKDDTLLVRCEVSTRFDMGSLRREGFQPRSTDAGV
490 500 510 520
>>NP_665802 (OMIM: 602355) TNF receptor-associated facto (522 aa)
initn: 711 init1: 143 opt: 641 Z-score: 360.8 bits: 76.2 E(85289): 2.3e-13
Smith-Waterman score: 746; 26.7% identity (58.0% similar) in 469 aa overlap (1-462:53-499)
10 20 30
pF1KE1 MPGFDYKFLEKPKRRLLCPLCGKPMREPVQ
. :.: .: . . ::.: .:: ::
NP_665 MASSCSAVTKDDSVGGTASTGNLSSSFMEEIQGYDVEFDPPLESKYECPICLMALREAVQ
30 40 50 60 70 80
40 50 60 70 80 90
pF1KE1 VSTCGHRFCDTCLQEFLSEGVFKCPEDQLPLDYAKIYPDPELEVQVLGLPIRCIHSEEGC
. :::::: .:. . . .. ::: :. : ...:: . ..:.: ..: .:::
NP_665 -TPCGHRFCKACIIKSIRDAGHKCPVDNEILLENQLFPDNFAKREILSLMVKC--PNEGC
90 100 110 120 130
100 110 120 130 140 150
pF1KE1 RWSGPLRHLQGHLNTCSFNVIPCPNRCPMKLSRRDLPAHLQHDCPKRRLKCEFCGCDFSG
. ::::. : : : .. :: .: ... . :. .:::.:...:. :. ...
NP_665 LHKMELRHLEDHQAHCEFALMDCP-QCQRPFQKFHINIHILKDCPRRQVSCDNCAASMAF
140 150 160 170 180 190
160 170 180 190 200
pF1KE1 EAYESHEGMCPQESVYCENKCGARMMRRLLAQHATSECPKRTQPCTY----CTKEFVFDT
: : :. :: .: :: :.. ..:. . .: .:: :::. : ... .
NP_665 EDKEIHDQNCPLANVICEY-CNTILIREQMPNHYDLDCPTAPIPCTFSTFGCHEKMQRNH
200 210 220 230 240 250
210 220 230 240 250 260
pF1KE1 IQSHQYQCPRLPVACPNQCGVGTVAREDLPGHLKDSCNTALVLCPFKDSGCKHRCP-KLA
. : . . . : .: ... :.... : :... :. .:.
NP_665 LARHLQENTQSHMRMLAQ-AVHSLSVIPDSGYISEVRN-------FQET--IHQLEGRLV
260 270 280 290 300
270 280 290 300 310 320
pF1KE1 MARHVEESVKPHLAMMCALVSRQRQELQELRRELEELSVGS-DGVLIWKIGSYGRRLQEA
: . . .. . ::. .. .. :. .. :. . . .:. :::::..: .:.
NP_665 RQDHQIRELTAKMETQSMYVSELKRTIRTLEDKVAEIEAQQCNGIYIWKIGNFGMHLKCQ
310 320 330 340 350 360
330 340 350 360 370 380
pF1KE1 KAKPNLECFSPAFYTHKYGYKLQVSAFLN-GNGSGEGTHLSLYIRVLPGAFDNLLEWPFA
. . . ::.::: : :::: . :. ... ....::..... : .:. : :::
NP_665 EEEKPVVIHSPGFYTGKPGYKLCMRLHLQLPTAQRCANYISLFVHTMQGEYDSHLPWPFQ
370 380 390 400 410 420
390 400 410 420 430 440
pF1KE1 RRVTFSLLDQSDPGLAKPQHVTETFHPDPNWKNFQKPGTWRGSLDESSLGFGYPKFISHQ
. ...::::. . . .: : . :. ::.: .. .. :::: :. .
NP_665 GTIRLTILDQSEAPV-RQNH-EEIMDAKPELLAFQRP-----TIPRNPKGFGYVTFMHLE
430 440 450 460 470 480
450 460 470
pF1KE1 DIRKRNYVRDDAVFIRAAVELPRKILS
.:.:....::....: :
NP_665 ALRQRTFIKDDTLLVRCEVSTRFDMGSLRREGFQPRSTDAGV
490 500 510 520
>>XP_011517280 (OMIM: 601895) PREDICTED: TNF receptor-as (501 aa)
initn: 729 init1: 333 opt: 416 Z-score: 244.3 bits: 54.6 E(85289): 7.2e-07
Smith-Waterman score: 785; 30.8% identity (56.5% similar) in 503 aa overlap (2-464:17-498)
10 20 30 40
pF1KE1 MPGFDYKFL-EKPKRRLLCPLCGKPMREPVQVSTCGHRFCDTCLQ
:::. .: : . . :: : . .:.: :.. ::::.:. ::
XP_011 MAAASVTPPGSLELLQPGFSKTLLGTKLEAKYLCSACRNVLRRPFQAQ-CGHRYCSFCLA
10 20 30 40 50
50 60 70 80 90
pF1KE1 EFLSEGVFKCP--------EDQLP-LDYAKIYPDPELEVQVLGLPIRCIHSEEGCRWSGP
.:: : .: :. . :. .. .:: . .: .:: : .:: :.:
XP_011 SILSSGPQNCAACVHEGIYEEGISILESSSAFPDNAARREVESLPAVC--PSDGCTWKGT
60 70 80 90 100 110
100 110 120 130 140 150
pF1KE1 LRHLQG-HLNTCSFNVIPCPNRCPMKLSRRDLPAHLQHDCPKRRLKCEFCGCDFSGEAYE
:.. .. : . : . . :: : . . ::.:.::.: :.:. : : .
XP_011 LKEYESCHEGRCPLMLTECPA-CKGLVRLGEKERHLEHECPERSLSCRHCRAPCCGADVK
120 130 140 150 160 170
160 170 180 190 200 210
pF1KE1 SHEGMCPQESVYCENKCGARMMRRLLAQHATSECPKRTQPCTY----CTKEFVFDTIQSH
.:. .::. . :.. :: . . : : .. : : :: . : . . : :
XP_011 AHHEVCPKFPLTCDG-CGKKKIPREKFQDHVKTCGKCRVPCRFHAIGCLETVEGEKQQEH
180 190 200 210 220 230
220 230 240 250 260
pF1KE1 QYQCPRLPVACPNQCGVGTVAREDLPGHLKDSCNTALVLCP--------FKDSGC--KHR
. : : .: . ... . : : . . . : : :.. : ...
XP_011 EVQWLREHLA---MLLSSVLEAKPLLGDQSHAGSELLQRCESLEKKTATFENIVCVLNRE
240 250 260 270 280 290
270 280 290 300
pF1KE1 CPKLAMARHVEESVKPH---LAMMCALVSRQRQ----------ELQELRRELEELSVGS-
..::. .: . : . :: :. .: . .:.... :. ...
XP_011 VERVAMT--AEACSRQHRLDQDKIEALSSKVQQLERSIGLKDLAMADLEQKVLEMEASTY
300 310 320 330 340 350
310 320 330 340 350 360
pF1KE1 DGVLIWKIGSYGRRLQEAKAKPNLECFSPAFYTHKYGYKLQVSAFLNGNGSGEGTHLSLY
:::.::::....:. ::: : ::::::: .::::. . .:::.:.:.::::::.
XP_011 DGVFIWKISDFARKRQEAVAGRIPAIFSPAFYTSRYGYKMCLRIYLNGDGTGRGTHLSLF
360 370 380 390 400 410
370 380 390 400 410 420
pF1KE1 IRVLPGAFDNLLEWPFARRVTFSLLDQSDPGLAKPQHVTETFHPDPNWKNFQKPGTWRGS
. :. : : ::.::: ..::. ::::.. .:: ..:.:: . ..::.:
XP_011 FVVMKGPNDALLRWPFNQKVTLMLLDQNNR-----EHVIDAFRPDVTSSSFQRP------
420 430 440 450
430 440 450 460 470
pF1KE1 LDESSLGFGYPKFISHQDIRKRN-YVRDDAVFIRAAVELPRKILS
... ... : : : . .. .: ::::::.::.: :.:
XP_011 VNDMNIASGCPLFCPVSKMEAKNSYVRDDAIFIKAIVDLTGL
460 470 480 490 500
>>NP_066961 (OMIM: 601895) TNF receptor-associated facto (501 aa)
initn: 729 init1: 333 opt: 416 Z-score: 244.3 bits: 54.6 E(85289): 7.2e-07
Smith-Waterman score: 785; 30.8% identity (56.5% similar) in 503 aa overlap (2-464:17-498)
10 20 30 40
pF1KE1 MPGFDYKFL-EKPKRRLLCPLCGKPMREPVQVSTCGHRFCDTCLQ
:::. .: : . . :: : . .:.: :.. ::::.:. ::
NP_066 MAAASVTPPGSLELLQPGFSKTLLGTKLEAKYLCSACRNVLRRPFQAQ-CGHRYCSFCLA
10 20 30 40 50
50 60 70 80 90
pF1KE1 EFLSEGVFKCP--------EDQLP-LDYAKIYPDPELEVQVLGLPIRCIHSEEGCRWSGP
.:: : .: :. . :. .. .:: . .: .:: : .:: :.:
NP_066 SILSSGPQNCAACVHEGIYEEGISILESSSAFPDNAARREVESLPAVC--PSDGCTWKGT
60 70 80 90 100 110
100 110 120 130 140 150
pF1KE1 LRHLQG-HLNTCSFNVIPCPNRCPMKLSRRDLPAHLQHDCPKRRLKCEFCGCDFSGEAYE
:.. .. : . : . . :: : . . ::.:.::.: :.:. : : .
NP_066 LKEYESCHEGRCPLMLTECPA-CKGLVRLGEKERHLEHECPERSLSCRHCRAPCCGADVK
120 130 140 150 160 170
160 170 180 190 200 210
pF1KE1 SHEGMCPQESVYCENKCGARMMRRLLAQHATSECPKRTQPCTY----CTKEFVFDTIQSH
.:. .::. . :.. :: . . : : .. : : :: . : . . : :
NP_066 AHHEVCPKFPLTCDG-CGKKKIPREKFQDHVKTCGKCRVPCRFHAIGCLETVEGEKQQEH
180 190 200 210 220 230
220 230 240 250 260
pF1KE1 QYQCPRLPVACPNQCGVGTVAREDLPGHLKDSCNTALVLCP--------FKDSGC--KHR
. : : .: . ... . : : . . . : : :.. : ...
NP_066 EVQWLREHLA---MLLSSVLEAKPLLGDQSHAGSELLQRCESLEKKTATFENIVCVLNRE
240 250 260 270 280 290
270 280 290 300
pF1KE1 CPKLAMARHVEESVKPH---LAMMCALVSRQRQ----------ELQELRRELEELSVGS-
..::. .: . : . :: :. .: . .:.... :. ...
NP_066 VERVAMT--AEACSRQHRLDQDKIEALSSKVQQLERSIGLKDLAMADLEQKVLEMEASTY
300 310 320 330 340 350
310 320 330 340 350 360
pF1KE1 DGVLIWKIGSYGRRLQEAKAKPNLECFSPAFYTHKYGYKLQVSAFLNGNGSGEGTHLSLY
:::.::::....:. ::: : ::::::: .::::. . .:::.:.:.::::::.
NP_066 DGVFIWKISDFARKRQEAVAGRIPAIFSPAFYTSRYGYKMCLRIYLNGDGTGRGTHLSLF
360 370 380 390 400 410
370 380 390 400 410 420
pF1KE1 IRVLPGAFDNLLEWPFARRVTFSLLDQSDPGLAKPQHVTETFHPDPNWKNFQKPGTWRGS
. :. : : ::.::: ..::. ::::.. .:: ..:.:: . ..::.:
NP_066 FVVMKGPNDALLRWPFNQKVTLMLLDQNNR-----EHVIDAFRPDVTSSSFQRP------
420 430 440 450
430 440 450 460 470
pF1KE1 LDESSLGFGYPKFISHQDIRKRN-YVRDDAVFIRAAVELPRKILS
... ... : : : . .. .: ::::::.::.: :.:
NP_066 VNDMNIASGCPLFCPVSKMEAKNSYVRDDAIFIKAIVDLTGL
460 470 480 490 500
470 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sat Nov 5 07:44:55 2016 done: Sat Nov 5 07:44:56 2016
Total Scan time: 10.070 Total Display time: 0.100
Function used was FASTA [36.3.4 Apr, 2011]