FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE3521, 455 aa 1>>>pF1KE3521 455 - 455 aa - 455 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 10.4459+/-0.000976; mu= -4.9142+/- 0.059 mean_var=306.4852+/-61.441, 0's: 0 Z-trim(115.5): 53 B-trim: 0 in 0/50 Lambda= 0.073260 statistics sampled from 16022 (16072) to 16022 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.794), E-opt: 0.2 (0.494), width: 16 Scan time: 3.670 The best scores are: opt bits E(32554) CCDS81504.1 TCF7L2 gene_id:6934|Hs108|chr10 ( 455) 2977 327.9 1.3e-89 CCDS55729.1 TCF7L2 gene_id:6934|Hs108|chr10 ( 459) 2959 326.0 4.9e-89 CCDS7576.1 TCF7L2 gene_id:6934|Hs108|chr10 ( 596) 2959 326.1 6e-89 CCDS73197.1 TCF7L2 gene_id:6934|Hs108|chr10 ( 579) 2835 313.0 5.2e-85 CCDS53577.1 TCF7L2 gene_id:6934|Hs108|chr10 ( 602) 1992 223.9 3.5e-58 CCDS73196.1 TCF7L2 gene_id:6934|Hs108|chr10 ( 476) 1881 212.1 1e-54 CCDS73198.1 TCF7L2 gene_id:6934|Hs108|chr10 ( 408) 1780 201.4 1.5e-51 CCDS53578.1 TCF7L2 gene_id:6934|Hs108|chr10 ( 489) 1767 200.1 4.3e-51 CCDS1971.1 TCF7L1 gene_id:83439|Hs108|chr2 ( 588) 1521 174.1 3.4e-43 CCDS3679.1 LEF1 gene_id:51176|Hs108|chr4 ( 399) 1291 149.7 5.2e-36 CCDS54791.1 LEF1 gene_id:51176|Hs108|chr4 ( 303) 788 96.4 4.2e-20 CCDS47123.1 LEF1 gene_id:51176|Hs108|chr4 ( 371) 788 96.5 4.9e-20 CCDS47122.1 LEF1 gene_id:51176|Hs108|chr4 ( 386) 788 96.5 5.1e-20 CCDS47263.2 TCF7 gene_id:6932|Hs108|chr5 ( 269) 705 87.6 1.7e-17 CCDS43362.1 TCF7 gene_id:6932|Hs108|chr5 ( 268) 701 87.2 2.3e-17 CCDS4170.1 TCF7 gene_id:6932|Hs108|chr5 ( 269) 699 87.0 2.6e-17 CCDS4169.1 TCF7 gene_id:6932|Hs108|chr5 ( 384) 699 87.1 3.4e-17 >>CCDS81504.1 TCF7L2 gene_id:6934|Hs108|chr10 (455 aa) initn: 2977 init1: 2977 opt: 2977 Z-score: 1722.3 bits: 327.9 E(32554): 1.3e-89 Smith-Waterman score: 2977; 100.0% identity (100.0% similar) in 429 aa overlap (1-429:1-429) 10 20 30 40 50 60 pF1KE3 MPQLNGGGGDDLGANDELISFKDEGEQEEKSSENSSAERDLADVKSSLVNESETNQNSSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS81 MPQLNGGGGDDLGANDELISFKDEGEQEEKSSENSSAERDLADVKSSLVNESETNQNSSS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 DSEAERRPPPRSESFRDKSRESLEEAAKRQDGGLFKGPPYPGYPFIMIPDLTSPYLPNGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS81 DSEAERRPPPRSESFRDKSRESLEEAAKRQDGGLFKGPPYPGYPFIMIPDLTSPYLPNGS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 LSPTARTYLQMKWPLLDVQAGSLQSRQALKDARSPSPAHIVSNKVPVVQHPHHVHPLTPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS81 LSPTARTYLQMKWPLLDVQAGSLQSRQALKDARSPSPAHIVSNKVPVVQHPHHVHPLTPL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 ITYSNEHFTPGNPPPHLPADVDPKTGIPRPPHPPDISPYYPLSPGTVGQIPHPLGWQGQP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS81 ITYSNEHFTPGNPPPHLPADVDPKTGIPRPPHPPDISPYYPLSPGTVGQIPHPLGWQGQP 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 VYPITTGGFRHPYPTALTVNASMSRFPPHMVPPHHTLHTTGIPHPAIVTPTVKQESSQSD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS81 VYPITTGGFRHPYPTALTVNASMSRFPPHMVPPHHTLHTTGIPHPAIVTPTVKQESSQSD 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE3 VGSLHSSKHQDSKKEEEKKKPHIKKPLNAFMLYMKEMRAKVVAECTLKESAAINQILGRR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS81 VGSLHSSKHQDSKKEEEKKKPHIKKPLNAFMLYMKEMRAKVVAECTLKESAAINQILGRR 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE3 WHALSREEQAKYYELARKERQLHMQLYPGWSARDNYGKKKKRKRDKQPGETNEHSECFLN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS81 WHALSREEQAKYYELARKERQLHMQLYPGWSARDNYGKKKKRKRDKQPGETNEHSECFLN 370 380 390 400 410 420 430 440 450 pF1KE3 PCLSLPPITGEKKSAFATYKVKAAASAHPLQMEAY ::::::::: CCDS81 PCLSLPPITDLSAPKKCRARFGLDQQNNWCGPCSL 430 440 450 >>CCDS55729.1 TCF7L2 gene_id:6934|Hs108|chr10 (459 aa) initn: 2963 init1: 1646 opt: 2959 Z-score: 1711.9 bits: 326.0 E(32554): 4.9e-89 Smith-Waterman score: 2959; 99.1% identity (99.1% similar) in 433 aa overlap (1-429:1-433) 10 20 30 40 50 60 pF1KE3 MPQLNGGGGDDLGANDELISFKDEGEQEEKSSENSSAERDLADVKSSLVNESETNQNSSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS55 MPQLNGGGGDDLGANDELISFKDEGEQEEKSSENSSAERDLADVKSSLVNESETNQNSSS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 DSEAERRPPPRSESFRDKSRESLEEAAKRQDGGLFKGPPYPGYPFIMIPDLTSPYLPNGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS55 DSEAERRPPPRSESFRDKSRESLEEAAKRQDGGLFKGPPYPGYPFIMIPDLTSPYLPNGS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 LSPTARTYLQMKWPLLDVQAGSLQSRQALKDARSPSPAHIVSNKVPVVQHPHHVHPLTPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS55 LSPTARTYLQMKWPLLDVQAGSLQSRQALKDARSPSPAHIVSNKVPVVQHPHHVHPLTPL 130 140 150 160 170 180 190 200 210 220 230 pF1KE3 ITYSNEHFTPGNPPPHLPADVDPKTGIPRPPHPPDISPYYPLSPGTVGQIPHPLGW---- :::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS55 ITYSNEHFTPGNPPPHLPADVDPKTGIPRPPHPPDISPYYPLSPGTVGQIPHPLGWLVPQ 190 200 210 220 230 240 240 250 260 270 280 290 pF1KE3 QGQPVYPITTGGFRHPYPTALTVNASMSRFPPHMVPPHHTLHTTGIPHPAIVTPTVKQES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS55 QGQPVYPITTGGFRHPYPTALTVNASMSRFPPHMVPPHHTLHTTGIPHPAIVTPTVKQES 250 260 270 280 290 300 300 310 320 330 340 350 pF1KE3 SQSDVGSLHSSKHQDSKKEEEKKKPHIKKPLNAFMLYMKEMRAKVVAECTLKESAAINQI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS55 SQSDVGSLHSSKHQDSKKEEEKKKPHIKKPLNAFMLYMKEMRAKVVAECTLKESAAINQI 310 320 330 340 350 360 360 370 380 390 400 410 pF1KE3 LGRRWHALSREEQAKYYELARKERQLHMQLYPGWSARDNYGKKKKRKRDKQPGETNEHSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS55 LGRRWHALSREEQAKYYELARKERQLHMQLYPGWSARDNYGKKKKRKRDKQPGETNEHSE 370 380 390 400 410 420 420 430 440 450 pF1KE3 CFLNPCLSLPPITGEKKSAFATYKVKAAASAHPLQMEAY ::::::::::::: CCDS55 CFLNPCLSLPPITDLSAPKKCRARFGLDQQNNWCGPCSL 430 440 450 >>CCDS7576.1 TCF7L2 gene_id:6934|Hs108|chr10 (596 aa) initn: 2963 init1: 1646 opt: 2959 Z-score: 1710.4 bits: 326.1 E(32554): 6e-89 Smith-Waterman score: 2959; 99.1% identity (99.1% similar) in 433 aa overlap (1-429:1-433) 10 20 30 40 50 60 pF1KE3 MPQLNGGGGDDLGANDELISFKDEGEQEEKSSENSSAERDLADVKSSLVNESETNQNSSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS75 MPQLNGGGGDDLGANDELISFKDEGEQEEKSSENSSAERDLADVKSSLVNESETNQNSSS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 DSEAERRPPPRSESFRDKSRESLEEAAKRQDGGLFKGPPYPGYPFIMIPDLTSPYLPNGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS75 DSEAERRPPPRSESFRDKSRESLEEAAKRQDGGLFKGPPYPGYPFIMIPDLTSPYLPNGS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 LSPTARTYLQMKWPLLDVQAGSLQSRQALKDARSPSPAHIVSNKVPVVQHPHHVHPLTPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS75 LSPTARTYLQMKWPLLDVQAGSLQSRQALKDARSPSPAHIVSNKVPVVQHPHHVHPLTPL 130 140 150 160 170 180 190 200 210 220 230 pF1KE3 ITYSNEHFTPGNPPPHLPADVDPKTGIPRPPHPPDISPYYPLSPGTVGQIPHPLGW---- :::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS75 ITYSNEHFTPGNPPPHLPADVDPKTGIPRPPHPPDISPYYPLSPGTVGQIPHPLGWLVPQ 190 200 210 220 230 240 240 250 260 270 280 290 pF1KE3 QGQPVYPITTGGFRHPYPTALTVNASMSRFPPHMVPPHHTLHTTGIPHPAIVTPTVKQES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS75 QGQPVYPITTGGFRHPYPTALTVNASMSRFPPHMVPPHHTLHTTGIPHPAIVTPTVKQES 250 260 270 280 290 300 300 310 320 330 340 350 pF1KE3 SQSDVGSLHSSKHQDSKKEEEKKKPHIKKPLNAFMLYMKEMRAKVVAECTLKESAAINQI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS75 SQSDVGSLHSSKHQDSKKEEEKKKPHIKKPLNAFMLYMKEMRAKVVAECTLKESAAINQI 310 320 330 340 350 360 360 370 380 390 400 410 pF1KE3 LGRRWHALSREEQAKYYELARKERQLHMQLYPGWSARDNYGKKKKRKRDKQPGETNEHSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS75 LGRRWHALSREEQAKYYELARKERQLHMQLYPGWSARDNYGKKKKRKRDKQPGETNEHSE 370 380 390 400 410 420 420 430 440 450 pF1KE3 CFLNPCLSLPPITGEKKSAFATYKVKAAASAHPLQMEAY ::::::::::::: CCDS75 CFLNPCLSLPPITDLSAPKKCRARFGLDQQNNWCGPCRRKKKCVRYIQGEGSCLSPPSSD 430 440 450 460 470 480 >>CCDS73197.1 TCF7L2 gene_id:6934|Hs108|chr10 (579 aa) initn: 2887 init1: 1646 opt: 2835 Z-score: 1639.7 bits: 313.0 E(32554): 5.2e-85 Smith-Waterman score: 2835; 98.6% identity (98.8% similar) in 419 aa overlap (1-415:1-419) 10 20 30 40 50 60 pF1KE3 MPQLNGGGGDDLGANDELISFKDEGEQEEKSSENSSAERDLADVKSSLVNESETNQNSSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS73 MPQLNGGGGDDLGANDELISFKDEGEQEEKSSENSSAERDLADVKSSLVNESETNQNSSS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 DSEAERRPPPRSESFRDKSRESLEEAAKRQDGGLFKGPPYPGYPFIMIPDLTSPYLPNGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS73 DSEAERRPPPRSESFRDKSRESLEEAAKRQDGGLFKGPPYPGYPFIMIPDLTSPYLPNGS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 LSPTARTYLQMKWPLLDVQAGSLQSRQALKDARSPSPAHIVSNKVPVVQHPHHVHPLTPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS73 LSPTARTYLQMKWPLLDVQAGSLQSRQALKDARSPSPAHIVSNKVPVVQHPHHVHPLTPL 130 140 150 160 170 180 190 200 210 220 230 pF1KE3 ITYSNEHFTPGNPPPHLPADVDPKTGIPRPPHPPDISPYYPLSPGTVGQIPHPLGW---- :::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS73 ITYSNEHFTPGNPPPHLPADVDPKTGIPRPPHPPDISPYYPLSPGTVGQIPHPLGWLVPQ 190 200 210 220 230 240 240 250 260 270 280 290 pF1KE3 QGQPVYPITTGGFRHPYPTALTVNASMSRFPPHMVPPHHTLHTTGIPHPAIVTPTVKQES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS73 QGQPVYPITTGGFRHPYPTALTVNASMSRFPPHMVPPHHTLHTTGIPHPAIVTPTVKQES 250 260 270 280 290 300 300 310 320 330 340 350 pF1KE3 SQSDVGSLHSSKHQDSKKEEEKKKPHIKKPLNAFMLYMKEMRAKVVAECTLKESAAINQI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS73 SQSDVGSLHSSKHQDSKKEEEKKKPHIKKPLNAFMLYMKEMRAKVVAECTLKESAAINQI 310 320 330 340 350 360 360 370 380 390 400 410 pF1KE3 LGRRWHALSREEQAKYYELARKERQLHMQLYPGWSARDNYGKKKKRKRDKQPGETNEHSE ::::::::::::::::::::::::::::::::::::::::::::::::::::::::. : CCDS73 LGRRWHALSREEQAKYYELARKERQLHMQLYPGWSARDNYGKKKKRKRDKQPGETNDLSA 370 380 390 400 410 420 420 430 440 450 pF1KE3 CFLNPCLSLPPITGEKKSAFATYKVKAAASAHPLQMEAY CCDS73 PKKCRARFGLDQQNNWCGPCRRKKKCVRYIQGEGSCLSPPSSDGSLLDSPPPSPNLLGSP 430 440 450 460 470 480 >>CCDS53577.1 TCF7L2 gene_id:6934|Hs108|chr10 (602 aa) initn: 2110 init1: 1205 opt: 1992 Z-score: 1158.0 bits: 223.9 E(32554): 3.5e-58 Smith-Waterman score: 2777; 93.6% identity (93.9% similar) in 440 aa overlap (1-413:1-440) 10 20 30 40 50 60 pF1KE3 MPQLNGGGGDDLGANDELISFKDEGEQEEKSSENSSAERDLADVKSSLVNESETNQNSSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS53 MPQLNGGGGDDLGANDELISFKDEGEQEEKSSENSSAERDLADVKSSLVNESETNQNSSS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 DSEAERRPPPRSESFRDKSRESLEEAAKRQDGGLFKGPPYPGYPFIMIPDLTSPYLPNGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS53 DSEAERRPPPRSESFRDKSRESLEEAAKRQDGGLFKGPPYPGYPFIMIPDLTSPYLPNGS 70 80 90 100 110 120 130 140 150 pF1KE3 LSPTART-----------------------YLQMKWPLLDVQAGSLQSRQALKDARSPSP ::::::: :::::::::::::::::::::::::::::: CCDS53 LSPTARTLHFQSGSTHYSAYKTIEHQIAVQYLQMKWPLLDVQAGSLQSRQALKDARSPSP 130 140 150 160 170 180 160 170 180 190 200 210 pF1KE3 AHIVSNKVPVVQHPHHVHPLTPLITYSNEHFTPGNPPPHLPADVDPKTGIPRPPHPPDIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS53 AHIVSNKVPVVQHPHHVHPLTPLITYSNEHFTPGNPPPHLPADVDPKTGIPRPPHPPDIS 190 200 210 220 230 240 220 230 240 250 260 270 pF1KE3 PYYPLSPGTVGQIPHPLGW----QGQPVYPITTGGFRHPYPTALTVNASMSRFPPHMVPP ::::::::::::::::::: ::::::::::::::::::::::::::::::::::::: CCDS53 PYYPLSPGTVGQIPHPLGWLVPQQGQPVYPITTGGFRHPYPTALTVNASMSRFPPHMVPP 250 260 270 280 290 300 280 290 300 310 320 330 pF1KE3 HHTLHTTGIPHPAIVTPTVKQESSQSDVGSLHSSKHQDSKKEEEKKKPHIKKPLNAFMLY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS53 HHTLHTTGIPHPAIVTPTVKQESSQSDVGSLHSSKHQDSKKEEEKKKPHIKKPLNAFMLY 310 320 330 340 350 360 340 350 360 370 380 390 pF1KE3 MKEMRAKVVAECTLKESAAINQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS53 MKEMRAKVVAECTLKESAAINQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSAR 370 380 390 400 410 420 400 410 420 430 440 450 pF1KE3 DNYGKKKKRKRDKQPGETNEHSECFLNPCLSLPPITGEKKSAFATYKVKAAASAHPLQME :::::::::::::::::::. CCDS53 DNYGKKKKRKRDKQPGETNDANTPKKCRALFGLDRQTLWCKPCRRKKKCVRYIQGEGSCL 430 440 450 460 470 480 >>CCDS73196.1 TCF7L2 gene_id:6934|Hs108|chr10 (476 aa) initn: 2775 init1: 1646 opt: 1881 Z-score: 1096.0 bits: 212.1 E(32554): 1e-54 Smith-Waterman score: 2939; 97.9% identity (97.9% similar) in 438 aa overlap (1-429:1-438) 10 20 30 40 50 60 pF1KE3 MPQLNGGGGDDLGANDELISFKDEGEQEEKSSENSSAERDLADVKSSLVNESETNQNSSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS73 MPQLNGGGGDDLGANDELISFKDEGEQEEKSSENSSAERDLADVKSSLVNESETNQNSSS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 DSEAERRPPPRSESFRDKSRESLEEAAKRQDGGLFKGPPYPGYPFIMIPDLTSPYLPNGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS73 DSEAERRPPPRSESFRDKSRESLEEAAKRQDGGLFKGPPYPGYPFIMIPDLTSPYLPNGS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 LSPTARTYLQMKWPLLDVQAGSLQSRQALKDARSPSPAHIVSNKVPVVQHPHHVHPLTPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS73 LSPTARTYLQMKWPLLDVQAGSLQSRQALKDARSPSPAHIVSNKVPVVQHPHHVHPLTPL 130 140 150 160 170 180 190 200 210 220 230 pF1KE3 ITYSNEHFTPGNPPPHLPADVDPKTGIPRPPHPPDISPYYPLSPGTVGQIPHPLGW---- :::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS73 ITYSNEHFTPGNPPPHLPADVDPKTGIPRPPHPPDISPYYPLSPGTVGQIPHPLGWLVPQ 190 200 210 220 230 240 240 250 260 270 280 290 pF1KE3 QGQPVYPITTGGFRHPYPTALTVNASMS-----RFPPHMVPPHHTLHTTGIPHPAIVTPT :::::::::::::::::::::::::::: ::::::::::::::::::::::::::: CCDS73 QGQPVYPITTGGFRHPYPTALTVNASMSSFLSSRFPPHMVPPHHTLHTTGIPHPAIVTPT 250 260 270 280 290 300 300 310 320 330 340 350 pF1KE3 VKQESSQSDVGSLHSSKHQDSKKEEEKKKPHIKKPLNAFMLYMKEMRAKVVAECTLKESA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS73 VKQESSQSDVGSLHSSKHQDSKKEEEKKKPHIKKPLNAFMLYMKEMRAKVVAECTLKESA 310 320 330 340 350 360 360 370 380 390 400 410 pF1KE3 AINQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSARDNYGKKKKRKRDKQPGET :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS73 AINQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSARDNYGKKKKRKRDKQPGET 370 380 390 400 410 420 420 430 440 450 pF1KE3 NEHSECFLNPCLSLPPITGEKKSAFATYKVKAAASAHPLQMEAY :::::::::::::::::: CCDS73 NEHSECFLNPCLSLPPITDLSAPKKCRARFGLDQQNNWCGPCRCKYSKEVSGTVRA 430 440 450 460 470 >>CCDS73198.1 TCF7L2 gene_id:6934|Hs108|chr10 (408 aa) initn: 2208 init1: 1203 opt: 1780 Z-score: 1039.2 bits: 201.4 E(32554): 1.5e-51 Smith-Waterman score: 2643; 88.0% identity (88.0% similar) in 459 aa overlap (1-455:1-408) 10 20 30 40 50 60 pF1KE3 MPQLNGGGGDDLGANDELISFKDEGEQEEKSSENSSAERDLADVKSSLVNESETNQNSSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS73 MPQLNGGGGDDLGANDELISFKDEGEQEEKSSENSSAERDLADVKSSLVNESETNQNSSS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 DSEAERRPPPRSESFRDKSRESLEEAAKRQDGGLFKGPPYPGYPFIMIPDLTSPYLPNGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS73 DSEAERRPPPRSESFRDKSRESLEEAAKRQDGGLFKGPPYPGYPFIMIPDLTSPYLPNGS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 LSPTARTYLQMKWPLLDVQAGSLQSRQALKDARSPSPAHIVSNKVPVVQHPHHVHPLTPL ::::::: ::::::::::::::::::: CCDS73 LSPTART----------------------------------SNKVPVVQHPHHVHPLTPL 130 140 190 200 210 220 230 pF1KE3 ITYSNEHFTPGNPPPHLPADVDPKTGIPRPPHPPDISPYYPLSPGTVGQIPHPLGW---- :::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS73 ITYSNEHFTPGNPPPHLPADVDPKTGIPRPPHPPDISPYYPLSPGTVGQIPHPLGWLVPQ 150 160 170 180 190 200 240 250 260 270 280 290 pF1KE3 QGQPVYPITTGGFRHPYPTALTVNASMSRFPPHMVPPHHTLHTTGIPHPAIVTPTVKQES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS73 QGQPVYPITTGGFRHPYPTALTVNASMSRFPPHMVPPHHTLHTTGIPHPAIVTPTVKQES 210 220 230 240 250 260 300 310 320 330 340 350 pF1KE3 SQSDVGSLHSSKHQDSKKEEEKKKPHIKKPLNAFMLYMKEMRAKVVAECTLKESAAINQI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS73 SQSDVGSLHSSKHQDSKKEEEKKKPHIKKPLNAFMLYMKEMRAKVVAECTLKESAAINQI 270 280 290 300 310 320 360 370 380 390 400 410 pF1KE3 LGRRWHALSREEQAKYYELARKERQLHMQLYPGWSARDNYGKKKKRKRDKQPGETNEHSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS73 LGRRWHALSREEQAKYYELARKERQLHMQLYPGWSARDNYGKKKKRKRDKQPGETN---- 330 340 350 360 370 380 420 430 440 450 pF1KE3 CFLNPCLSLPPITGEKKSAFATYKVKAAASAHPLQMEAY :::::::::::::::::::::::::: CCDS73 -------------GEKKSAFATYKVKAAASAHPLQMEAY 390 400 >>CCDS53578.1 TCF7L2 gene_id:6934|Hs108|chr10 (489 aa) initn: 2441 init1: 1203 opt: 1767 Z-score: 1030.7 bits: 200.1 E(32554): 4.3e-51 Smith-Waterman score: 2712; 86.0% identity (86.0% similar) in 487 aa overlap (20-455:20-489) 10 20 30 40 50 60 pF1KE3 MPQLNGGGGDDLGANDELISFKDEGEQEEKSSENSSAERDLADVKSSLVNESETNQNSSS ::::::::::::::::::::::::::::::::::::::::: CCDS53 MPQLNGGGGDDLGANDELISFKDEGEQEEKSSENSSAERDLADVKSSLVNESETNQNSSS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 DSEAERRPPPRSESFRDKSRESLEEAAKRQDGGLFKGPPYPGYPFIMIPDLTSPYLPNGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS53 DSEAERRPPPRSESFRDKSRESLEEAAKRQDGGLFKGPPYPGYPFIMIPDLTSPYLPNGS 70 80 90 100 110 120 130 140 150 160 pF1KE3 LSPTARTYLQMKWPLLDVQAGSLQSRQALKDARSPSPAHIVS------------------ :::::::::::::::::::::::::::::::::::::::::: CCDS53 LSPTARTYLQMKWPLLDVQAGSLQSRQALKDARSPSPAHIVSPLPCCTQGHDCQHFYPPS 130 140 150 160 170 180 170 180 190 pF1KE3 -----------------------------NKVPVVQHPHHVHPLTPLITYSNEHFTPGNP ::::::::::::::::::::::::::::::: CCDS53 DFTVSTQVFRDMKRSHSLQKVGEPWCIESNKVPVVQHPHHVHPLTPLITYSNEHFTPGNP 190 200 210 220 230 240 200 210 220 230 240 pF1KE3 PPHLPADVDPKTGIPRPPHPPDISPYYPLSPGTVGQIPHPLGW----QGQPVYPITTGGF ::::::::::::::::::::::::::::::::::::::::::: ::::::::::::: CCDS53 PPHLPADVDPKTGIPRPPHPPDISPYYPLSPGTVGQIPHPLGWLVPQQGQPVYPITTGGF 250 260 270 280 290 300 250 260 270 280 290 300 pF1KE3 RHPYPTALTVNASMSRFPPHMVPPHHTLHTTGIPHPAIVTPTVKQESSQSDVGSLHSSKH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS53 RHPYPTALTVNASMSRFPPHMVPPHHTLHTTGIPHPAIVTPTVKQESSQSDVGSLHSSKH 310 320 330 340 350 360 310 320 330 340 350 360 pF1KE3 QDSKKEEEKKKPHIKKPLNAFMLYMKEMRAKVVAECTLKESAAINQILGRRWHALSREEQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS53 QDSKKEEEKKKPHIKKPLNAFMLYMKEMRAKVVAECTLKESAAINQILGRRWHALSREEQ 370 380 390 400 410 420 370 380 390 400 410 420 pF1KE3 AKYYELARKERQLHMQLYPGWSARDNYGKKKKRKRDKQPGETNEHSECFLNPCLSLPPIT ::::::::::::::::::::::::::::::::::::::::::: CCDS53 AKYYELARKERQLHMQLYPGWSARDNYGKKKKRKRDKQPGETN----------------- 430 440 450 460 430 440 450 pF1KE3 GEKKSAFATYKVKAAASAHPLQMEAY :::::::::::::::::::::::::: CCDS53 GEKKSAFATYKVKAAASAHPLQMEAY 470 480 >>CCDS1971.1 TCF7L1 gene_id:83439|Hs108|chr2 (588 aa) initn: 1611 init1: 676 opt: 1521 Z-score: 889.1 bits: 174.1 E(32554): 3.4e-43 Smith-Waterman score: 1988; 68.9% identity (82.2% similar) in 444 aa overlap (7-427:27-461) 10 20 30 pF1KE3 MPQLNGGGGDDLGANDELISFKDEG-EQEEKSSENSSAER ::::::::::::: :.::: :..: ::...::.: CCDS19 MPQLGGGGGGGGGGSGGGGGSSAGAAGGGDDLGANDELIPFQDEGGEEQEPSSDSASAQR 10 20 30 40 50 60 40 50 60 70 80 90 pF1KE3 DLADVKSSLVNESETNQNSSSDSEAERRPPPRSESFRDKSRESLEEAAKRQDGGLFKGPP :: .:::::::::: ::.::::::::::: : ..:. : :. . :. . ::...::::: CCDS19 DLDEVKSSLVNESE-NQSSSSDSEAERRPQPVRDTFQ-KPRDYFAEVRRPQDSAFFKGPP 70 80 90 100 110 100 110 120 130 140 150 pF1KE3 YPGYPFIMIPDLTSPYLPNGSLSPT-ARTYLQMKWPLLDVQAGSLQSRQALKDARSPSPA ::::::.:::::.:::: :: ::: :::::::::::::: : ..::.:::::: CCDS19 YPGYPFLMIPDLSSPYLSNGPLSPGGARTYLQMKWPLLDV-----PSSATVKDTRSPSPA 120 130 140 150 160 170 160 170 180 190 200 210 pF1KE3 HIVSNKVPVVQHPHHVHPLTPLITYSNEHFTPGNPPPHLPADVDPKTGIPRPPHPPDISP :. ::::::::::::.:::::::::::.::.::.:: :: ..:::::::::::: ..:: CCDS19 HL-SNKVPVVQHPHHMHPLTPLITYSNDHFSPGSPPTHLSPEIDPKTGIPRPPHPSELSP 180 190 200 210 220 230 220 230 240 250 260 pF1KE3 YYPLSPGTVGQIPHPLGW----QGQPVYPITTGGFRHPYPTALTVNASMS-----RFPPH :::::::.:::::::::: ::::.: . :::::::: ::..::::: :: :: CCDS19 YYPLSPGAVGQIPHPLGWLVPQQGQPMYSLPPGGFRHPYP-ALAMNASMSSLVSSRFSPH 240 250 260 270 280 290 270 280 290 300 310 320 pF1KE3 MVPPHHT-LHTTGIPHPAIVTPTVKQESSQSDVGSLHSSKHQDSKKEEEKKKPHIKKPLN :: : : : :.::::::::.: :::: . ... : : . :.::.::::.::::: CCDS19 MVAPAHPGLPTSGIPHPAIVSPIVKQEPAPPSLSPAVSVKSPVTVKKEEEKKPHVKKPLN 300 310 320 330 340 350 330 340 350 360 370 380 pF1KE3 AFMLYMKEMRAKVVAECTLKESAAINQILGRRWHALSREEQAKYYELARKERQLHMQLYP :::::::::::::::::::::::::::::::.:: :::::::::::::::::::: :::: CCDS19 AFMLYMKEMRAKVVAECTLKESAAINQILGRKWHNLSREEQAKYYELARKERQLHSQLYP 360 370 380 390 400 410 390 400 410 420 430 pF1KE3 GWSARDNYGKKKKRKRDKQPGETN-----EHSECFL-----NPCLS-LPPITGEKKSAFA :::::::::::::::.:: ..:. ...: : .::.. ::: CCDS19 TWSARDNYGKKKKRKREKQLSQTQSQQQVQEAEGALASKSKKPCVQYLPPEKPCDSPASS 420 430 440 450 460 470 440 450 pF1KE3 TYKVKAAASAHPLQMEAY CCDS19 HGSMLDSPATPSAALASPAAPAATHSEQAQPLSLTTKPETRAQLALHSAAFLSAKAAASS 480 490 500 510 520 530 >>CCDS3679.1 LEF1 gene_id:51176|Hs108|chr4 (399 aa) initn: 1582 init1: 863 opt: 1291 Z-score: 760.0 bits: 149.7 E(32554): 5.2e-36 Smith-Waterman score: 1549; 60.3% identity (74.4% similar) in 418 aa overlap (1-406:1-382) 10 20 30 40 50 pF1KE3 MPQLNGGGGD-----DLGANDELISFKDEGE-QEEKS-SENSSAER--DLADVKSSLVNE ::::.:::: .: :.::.: :::::. :.:: .: : :. ::::.::::::: CCDS36 MPQLSGGGGGGGGDPELCATDEMIPFKDEGDPQKEKIFAEISHPEEEGDLADIKSSLVNE 10 20 30 40 50 60 60 70 80 90 100 pF1KE3 SETNQNSSSDSEAERRPPPRSESFRDKSRESLEEAAKRQDGGLF-KGPPYPGYP-FIMIP :: .:. :. :. .: ..::.:: ... :. ::::. ::: : .: .::.: CCDS36 SEIIP-ASNGHEVARQAQTSQEPYHDKAREHPDDG-KHPDGGLYNKGPSYSSYSGYIMMP 70 80 90 100 110 110 120 130 140 150 160 pF1KE3 DLTS-PYLPNGSLSPTARTYLQMKWPLLDVQAGSLQSRQALKDARSPSPAHIVSNKVPVV .... ::. :::::: : : .::::::: CCDS36 NMNNDPYMSNGSLSP-------------------------------PIPR--TSNKVPVV 120 130 140 170 180 190 200 210 220 pF1KE3 QHPHHVHPLTPLITYSNEHFTPGNPPPHLPADVDPKTGIPRPPHPPDISPYYPLSPGTVG : : :::::::::::.:::.::. : :.:.::. : :. : : ::: .:::::: :: CCDS36 QPSHAVHPLTPLITYSDEHFSPGSHPSHIPSDVNSKQGMSRHPPAPDIPTFYPLSPGGVG 150 160 170 180 190 200 230 240 250 260 270 280 pF1KE3 QIPHPLGWQGQPVYPITTGGFRHPYPTALTVNASMSRFPPHMVPPHHTLHTTGIPHPAIV :: ::::::::::::: ::::.:::..:.:..::::: ::.: ::::::::::: CCDS36 QITPPLGWQGQPVYPIT-GGFRQPYPSSLSVDTSMSRFSHHMIPGPPGPHTTGIPHPAIV 210 220 230 240 250 260 290 300 310 320 330 340 pF1KE3 TPTVKQESSQSDVGSLHSSKHQDSKKEEEKKKPHIKKPLNAFMLYMKEMRAKVVAECTLK :: :::: ..: .: . .....::.: :.:::::::::::::::::::.:::::::: CCDS36 TPQVKQEHPHTDSDLMHVKPQHEQRKEQEPKRPHIKKPLNAFMLYMKEMRANVVAECTLK 270 280 290 300 310 320 350 360 370 380 390 400 pF1KE3 ESAAINQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSARDNYGKKKKRKRDKQP ::::::::::::::::::::::::::::::::::::::::::::::::::::::::.: CCDS36 ESAAINQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSARDNYGKKKKRKREKLQ 330 340 350 360 370 380 410 420 430 440 450 pF1KE3 GETNEHSECFLNPCLSLPPITGEKKSAFATYKVKAAASAHPLQMEAY CCDS36 ESASGTGPRMTAAYI 390 455 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 01:57:53 2016 done: Sat Nov 5 01:57:53 2016 Total Scan time: 3.670 Total Display time: 0.080 Function used was FASTA [36.3.4 Apr, 2011]