Result of FASTA (omim) for
pFN21AE1029
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE1029, 1273 aa
1>>>pF1KE1029 1273 - 1273 aa - 1273 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 15.0543+/-0.00053; mu= -22.0364+/- 0.033
mean_var=577.1628+/-120.126, 0's: 0 Z-trim(121.0): 14 B-trim: 735 in 1/58
Lambda= 0.053386
statistics sampled from 36926 (36940) to 36926 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.718), E-opt: 0.2 (0.433), width: 16
Scan time: 17.790
The best scores are: opt bits E(85289)
NP_056292 (OMIM: 607776,613406) paired amphipathic (1273) 8502 670.9 1.5e-191
NP_001138830 (OMIM: 607776,613406) paired amphipat (1273) 8502 670.9 1.5e-191
XP_006720529 (OMIM: 607776,613406) PREDICTED: pair (1273) 8502 670.9 1.5e-191
XP_006720528 (OMIM: 607776,613406) PREDICTED: pair (1273) 8502 670.9 1.5e-191
NP_001138829 (OMIM: 607776,613406) paired amphipat (1273) 8502 670.9 1.5e-191
XP_006720530 (OMIM: 607776,613406) PREDICTED: pair (1273) 8502 670.9 1.5e-191
NP_001284524 (OMIM: 607777) paired amphipathic hel (1130) 1885 161.2 3.6e-38
XP_006722767 (OMIM: 607777) PREDICTED: paired amph ( 645) 1377 121.9 1.4e-26
NP_001284526 (OMIM: 607777) paired amphipathic hel ( 720) 1377 122.0 1.5e-26
NP_056075 (OMIM: 607777) paired amphipathic helix (1162) 1377 122.1 2.2e-26
>>NP_056292 (OMIM: 607776,613406) paired amphipathic hel (1273 aa)
initn: 8502 init1: 8502 opt: 8502 Z-score: 3559.8 bits: 670.9 E(85289): 1.5e-191
Smith-Waterman score: 8502; 99.9% identity (100.0% similar) in 1273 aa overlap (1-1273:1-1273)
10 20 30 40 50 60
pF1KE1 MKRRLDDQESPVYAAQQRRIPGSTEAFPHQHRVLAPAPPVYEAVSETMQSATGIQYSVTP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 MKRRLDDQESPVYAAQQRRIPGSTEAFPHQHRVLAPAPPVYEAVSETMQSATGIQYSVTP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 SYQVSAMPQSSGSHGPAIAAVHSSHHHPTAVQPHGGQVVQSHAHPAPPAAPVQGQQQFQR
::::::::::::::::::::::::::::::::::::::::::::::::.:::::::::::
NP_056 SYQVSAMPQSSGSHGPAIAAVHSSHHHPTAVQPHGGQVVQSHAHPAPPVAPVQGQQQFQR
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 LKVEDALSYLDQVKLQFGSQPQVYNDFLDIMKEFKSQSIDTPGVISRVSQLFKGHPDLIM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 LKVEDALSYLDQVKLQFGSQPQVYNDFLDIMKEFKSQSIDTPGVISRVSQLFKGHPDLIM
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE1 GFNTFLPPGYKIEVQTNDMVNVTTPGQVHQIPTHGIQPQPQPPPQHPSQPSAQSAPAPAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 GFNTFLPPGYKIEVQTNDMVNVTTPGQVHQIPTHGIQPQPQPPPQHPSQPSAQSAPAPAQ
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE1 PAPQPPPAKVSKPSQLQAHTPASQQTPPLPPYASPRSPPVQPHTPVTISLGTAPSLQNNQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 PAPQPPPAKVSKPSQLQAHTPASQQTPPLPPYASPRSPPVQPHTPVTISLGTAPSLQNNQ
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE1 PVEFNHAINYVNKIKNRFQGQPDIYKAFLEILHTYQKEQRNAKEAGGNYTPALTEQEVYA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 PVEFNHAINYVNKIKNRFQGQPDIYKAFLEILHTYQKEQRNAKEAGGNYTPALTEQEVYA
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE1 QVARLFKNQEDLLSEFGQFLPDANSSVLLSKTTAEKVDSVRNDHGGTVKKPQLNNKPQRP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 QVARLFKNQEDLLSEFGQFLPDANSSVLLSKTTAEKVDSVRNDHGGTVKKPQLNNKPQRP
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE1 SQNGCQIRRHPTGTTPPVKKKPKLLNLKDSSMADASKHGGGTESLFFDKVRKALRSAEAY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 SQNGCQIRRHPTGTTPPVKKKPKLLNLKDSSMADASKHGGGTESLFFDKVRKALRSAEAY
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE1 ENFLRCLVIFNQEVISRAELVQLVSPFLGKFPELFNWFKNFLGYKESVHLETYPKERATE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 ENFLRCLVIFNQEVISRAELVQLVSPFLGKFPELFNWFKNFLGYKESVHLETYPKERATE
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE1 GIAMEIDYASCKRLGSSYRALPKSYQQPKCTGRTPLCKEVLNDTWVSFPSWSEDSTFVSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 GIAMEIDYASCKRLGSSYRALPKSYQQPKCTGRTPLCKEVLNDTWVSFPSWSEDSTFVSS
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE1 KKTQYEEHIYRCEDERFELDVVLETNLATIRVLEAIQKKLSRLSAEEQAKFRLDNTLGGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 KKTQYEEHIYRCEDERFELDVVLETNLATIRVLEAIQKKLSRLSAEEQAKFRLDNTLGGT
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE1 SEVIHRKALQRIYADKAADIIDGLRKNPSIAVPIVLKRLKMKEEEWREAQRGFNKVWREQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 SEVIHRKALQRIYADKAADIIDGLRKNPSIAVPIVLKRLKMKEEEWREAQRGFNKVWREQ
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE1 NEKYYLKSLDHQGINFKQNDTKVLRSKSLLNEIESIYDERQEQATEENAGVPVGPHLSLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 NEKYYLKSLDHQGINFKQNDTKVLRSKSLLNEIESIYDERQEQATEENAGVPVGPHLSLA
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE1 YEDKQILEDAAALIIHHVKRQTGIQKEDKYKIKQIMHHFIPDLLFAQRGDLSDVEEEEEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 YEDKQILEDAAALIIHHVKRQTGIQKEDKYKIKQIMHHFIPDLLFAQRGDLSDVEEEEEE
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE1 EMDVDEATGAVKKHNGVGGSPPKSKLLFSNTAAQKLRGMDEVYNLFYVNNNWYIFMRLHQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 EMDVDEATGAVKKHNGVGGSPPKSKLLFSNTAAQKLRGMDEVYNLFYVNNNWYIFMRLHQ
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE1 ILCLRLLRICSQAERQIEEENREREWEREVLGIKRDKSDSPAIQLRLKEPMDVDVEDYYP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 ILCLRLLRICSQAERQIEEENREREWEREVLGIKRDKSDSPAIQLRLKEPMDVDVEDYYP
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE1 AFLDMVRSLLDGNIDSSQYEDSLREMFTIHAYIAFTMDKLIQSIVRQLQHIVSDEICVQV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 AFLDMVRSLLDGNIDSSQYEDSLREMFTIHAYIAFTMDKLIQSIVRQLQHIVSDEICVQV
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KE1 TDLYLAENNNGATGGQLNTQNSRSLLESTYQRKAEQLMSDENCFKLMFIQSQGQVQLTIE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 TDLYLAENNNGATGGQLNTQNSRSLLESTYQRKAEQLMSDENCFKLMFIQSQGQVQLTIE
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KE1 LLDTEEENSDDPVEAERWSDYVERYMNSDTTSPELREHLAQKPVFLPRNLRRIRKCQRGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 LLDTEEENSDDPVEAERWSDYVERYMNSDTTSPELREHLAQKPVFLPRNLRRIRKCQRGR
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KE1 EQQEKEGKEGNSKKTMENVDSLDKLECRFKLNSYKMVYVIKSEDYMYRRTALLRAHQSHE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 EQQEKEGKEGNSKKTMENVDSLDKLECRFKLNSYKMVYVIKSEDYMYRRTALLRAHQSHE
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KE1 RVSKRLHQRFQAWVDKWTKEHVPREMAAETSKWLMGEGLEGLVPCTTTCDTETLHFVSIN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 RVSKRLHQRFQAWVDKWTKEHVPREMAAETSKWLMGEGLEGLVPCTTTCDTETLHFVSIN
1210 1220 1230 1240 1250 1260
1270
pF1KE1 KYRVKYGTVFKAP
:::::::::::::
NP_056 KYRVKYGTVFKAP
1270
>>NP_001138830 (OMIM: 607776,613406) paired amphipathic (1273 aa)
initn: 8502 init1: 8502 opt: 8502 Z-score: 3559.8 bits: 670.9 E(85289): 1.5e-191
Smith-Waterman score: 8502; 99.9% identity (100.0% similar) in 1273 aa overlap (1-1273:1-1273)
10 20 30 40 50 60
pF1KE1 MKRRLDDQESPVYAAQQRRIPGSTEAFPHQHRVLAPAPPVYEAVSETMQSATGIQYSVTP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MKRRLDDQESPVYAAQQRRIPGSTEAFPHQHRVLAPAPPVYEAVSETMQSATGIQYSVTP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 SYQVSAMPQSSGSHGPAIAAVHSSHHHPTAVQPHGGQVVQSHAHPAPPAAPVQGQQQFQR
::::::::::::::::::::::::::::::::::::::::::::::::.:::::::::::
NP_001 SYQVSAMPQSSGSHGPAIAAVHSSHHHPTAVQPHGGQVVQSHAHPAPPVAPVQGQQQFQR
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 LKVEDALSYLDQVKLQFGSQPQVYNDFLDIMKEFKSQSIDTPGVISRVSQLFKGHPDLIM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LKVEDALSYLDQVKLQFGSQPQVYNDFLDIMKEFKSQSIDTPGVISRVSQLFKGHPDLIM
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE1 GFNTFLPPGYKIEVQTNDMVNVTTPGQVHQIPTHGIQPQPQPPPQHPSQPSAQSAPAPAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GFNTFLPPGYKIEVQTNDMVNVTTPGQVHQIPTHGIQPQPQPPPQHPSQPSAQSAPAPAQ
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE1 PAPQPPPAKVSKPSQLQAHTPASQQTPPLPPYASPRSPPVQPHTPVTISLGTAPSLQNNQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PAPQPPPAKVSKPSQLQAHTPASQQTPPLPPYASPRSPPVQPHTPVTISLGTAPSLQNNQ
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE1 PVEFNHAINYVNKIKNRFQGQPDIYKAFLEILHTYQKEQRNAKEAGGNYTPALTEQEVYA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PVEFNHAINYVNKIKNRFQGQPDIYKAFLEILHTYQKEQRNAKEAGGNYTPALTEQEVYA
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE1 QVARLFKNQEDLLSEFGQFLPDANSSVLLSKTTAEKVDSVRNDHGGTVKKPQLNNKPQRP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QVARLFKNQEDLLSEFGQFLPDANSSVLLSKTTAEKVDSVRNDHGGTVKKPQLNNKPQRP
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE1 SQNGCQIRRHPTGTTPPVKKKPKLLNLKDSSMADASKHGGGTESLFFDKVRKALRSAEAY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SQNGCQIRRHPTGTTPPVKKKPKLLNLKDSSMADASKHGGGTESLFFDKVRKALRSAEAY
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE1 ENFLRCLVIFNQEVISRAELVQLVSPFLGKFPELFNWFKNFLGYKESVHLETYPKERATE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ENFLRCLVIFNQEVISRAELVQLVSPFLGKFPELFNWFKNFLGYKESVHLETYPKERATE
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE1 GIAMEIDYASCKRLGSSYRALPKSYQQPKCTGRTPLCKEVLNDTWVSFPSWSEDSTFVSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GIAMEIDYASCKRLGSSYRALPKSYQQPKCTGRTPLCKEVLNDTWVSFPSWSEDSTFVSS
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE1 KKTQYEEHIYRCEDERFELDVVLETNLATIRVLEAIQKKLSRLSAEEQAKFRLDNTLGGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KKTQYEEHIYRCEDERFELDVVLETNLATIRVLEAIQKKLSRLSAEEQAKFRLDNTLGGT
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE1 SEVIHRKALQRIYADKAADIIDGLRKNPSIAVPIVLKRLKMKEEEWREAQRGFNKVWREQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SEVIHRKALQRIYADKAADIIDGLRKNPSIAVPIVLKRLKMKEEEWREAQRGFNKVWREQ
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE1 NEKYYLKSLDHQGINFKQNDTKVLRSKSLLNEIESIYDERQEQATEENAGVPVGPHLSLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NEKYYLKSLDHQGINFKQNDTKVLRSKSLLNEIESIYDERQEQATEENAGVPVGPHLSLA
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE1 YEDKQILEDAAALIIHHVKRQTGIQKEDKYKIKQIMHHFIPDLLFAQRGDLSDVEEEEEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YEDKQILEDAAALIIHHVKRQTGIQKEDKYKIKQIMHHFIPDLLFAQRGDLSDVEEEEEE
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE1 EMDVDEATGAVKKHNGVGGSPPKSKLLFSNTAAQKLRGMDEVYNLFYVNNNWYIFMRLHQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EMDVDEATGAVKKHNGVGGSPPKSKLLFSNTAAQKLRGMDEVYNLFYVNNNWYIFMRLHQ
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE1 ILCLRLLRICSQAERQIEEENREREWEREVLGIKRDKSDSPAIQLRLKEPMDVDVEDYYP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ILCLRLLRICSQAERQIEEENREREWEREVLGIKRDKSDSPAIQLRLKEPMDVDVEDYYP
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE1 AFLDMVRSLLDGNIDSSQYEDSLREMFTIHAYIAFTMDKLIQSIVRQLQHIVSDEICVQV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AFLDMVRSLLDGNIDSSQYEDSLREMFTIHAYIAFTMDKLIQSIVRQLQHIVSDEICVQV
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KE1 TDLYLAENNNGATGGQLNTQNSRSLLESTYQRKAEQLMSDENCFKLMFIQSQGQVQLTIE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TDLYLAENNNGATGGQLNTQNSRSLLESTYQRKAEQLMSDENCFKLMFIQSQGQVQLTIE
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KE1 LLDTEEENSDDPVEAERWSDYVERYMNSDTTSPELREHLAQKPVFLPRNLRRIRKCQRGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LLDTEEENSDDPVEAERWSDYVERYMNSDTTSPELREHLAQKPVFLPRNLRRIRKCQRGR
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KE1 EQQEKEGKEGNSKKTMENVDSLDKLECRFKLNSYKMVYVIKSEDYMYRRTALLRAHQSHE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EQQEKEGKEGNSKKTMENVDSLDKLECRFKLNSYKMVYVIKSEDYMYRRTALLRAHQSHE
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KE1 RVSKRLHQRFQAWVDKWTKEHVPREMAAETSKWLMGEGLEGLVPCTTTCDTETLHFVSIN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RVSKRLHQRFQAWVDKWTKEHVPREMAAETSKWLMGEGLEGLVPCTTTCDTETLHFVSIN
1210 1220 1230 1240 1250 1260
1270
pF1KE1 KYRVKYGTVFKAP
:::::::::::::
NP_001 KYRVKYGTVFKAP
1270
>>XP_006720529 (OMIM: 607776,613406) PREDICTED: paired a (1273 aa)
initn: 8502 init1: 8502 opt: 8502 Z-score: 3559.8 bits: 670.9 E(85289): 1.5e-191
Smith-Waterman score: 8502; 99.9% identity (100.0% similar) in 1273 aa overlap (1-1273:1-1273)
10 20 30 40 50 60
pF1KE1 MKRRLDDQESPVYAAQQRRIPGSTEAFPHQHRVLAPAPPVYEAVSETMQSATGIQYSVTP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 MKRRLDDQESPVYAAQQRRIPGSTEAFPHQHRVLAPAPPVYEAVSETMQSATGIQYSVTP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 SYQVSAMPQSSGSHGPAIAAVHSSHHHPTAVQPHGGQVVQSHAHPAPPAAPVQGQQQFQR
::::::::::::::::::::::::::::::::::::::::::::::::.:::::::::::
XP_006 SYQVSAMPQSSGSHGPAIAAVHSSHHHPTAVQPHGGQVVQSHAHPAPPVAPVQGQQQFQR
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 LKVEDALSYLDQVKLQFGSQPQVYNDFLDIMKEFKSQSIDTPGVISRVSQLFKGHPDLIM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LKVEDALSYLDQVKLQFGSQPQVYNDFLDIMKEFKSQSIDTPGVISRVSQLFKGHPDLIM
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE1 GFNTFLPPGYKIEVQTNDMVNVTTPGQVHQIPTHGIQPQPQPPPQHPSQPSAQSAPAPAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GFNTFLPPGYKIEVQTNDMVNVTTPGQVHQIPTHGIQPQPQPPPQHPSQPSAQSAPAPAQ
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE1 PAPQPPPAKVSKPSQLQAHTPASQQTPPLPPYASPRSPPVQPHTPVTISLGTAPSLQNNQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PAPQPPPAKVSKPSQLQAHTPASQQTPPLPPYASPRSPPVQPHTPVTISLGTAPSLQNNQ
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE1 PVEFNHAINYVNKIKNRFQGQPDIYKAFLEILHTYQKEQRNAKEAGGNYTPALTEQEVYA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PVEFNHAINYVNKIKNRFQGQPDIYKAFLEILHTYQKEQRNAKEAGGNYTPALTEQEVYA
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE1 QVARLFKNQEDLLSEFGQFLPDANSSVLLSKTTAEKVDSVRNDHGGTVKKPQLNNKPQRP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 QVARLFKNQEDLLSEFGQFLPDANSSVLLSKTTAEKVDSVRNDHGGTVKKPQLNNKPQRP
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE1 SQNGCQIRRHPTGTTPPVKKKPKLLNLKDSSMADASKHGGGTESLFFDKVRKALRSAEAY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SQNGCQIRRHPTGTTPPVKKKPKLLNLKDSSMADASKHGGGTESLFFDKVRKALRSAEAY
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE1 ENFLRCLVIFNQEVISRAELVQLVSPFLGKFPELFNWFKNFLGYKESVHLETYPKERATE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ENFLRCLVIFNQEVISRAELVQLVSPFLGKFPELFNWFKNFLGYKESVHLETYPKERATE
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE1 GIAMEIDYASCKRLGSSYRALPKSYQQPKCTGRTPLCKEVLNDTWVSFPSWSEDSTFVSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GIAMEIDYASCKRLGSSYRALPKSYQQPKCTGRTPLCKEVLNDTWVSFPSWSEDSTFVSS
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE1 KKTQYEEHIYRCEDERFELDVVLETNLATIRVLEAIQKKLSRLSAEEQAKFRLDNTLGGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 KKTQYEEHIYRCEDERFELDVVLETNLATIRVLEAIQKKLSRLSAEEQAKFRLDNTLGGT
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE1 SEVIHRKALQRIYADKAADIIDGLRKNPSIAVPIVLKRLKMKEEEWREAQRGFNKVWREQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SEVIHRKALQRIYADKAADIIDGLRKNPSIAVPIVLKRLKMKEEEWREAQRGFNKVWREQ
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE1 NEKYYLKSLDHQGINFKQNDTKVLRSKSLLNEIESIYDERQEQATEENAGVPVGPHLSLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 NEKYYLKSLDHQGINFKQNDTKVLRSKSLLNEIESIYDERQEQATEENAGVPVGPHLSLA
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE1 YEDKQILEDAAALIIHHVKRQTGIQKEDKYKIKQIMHHFIPDLLFAQRGDLSDVEEEEEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 YEDKQILEDAAALIIHHVKRQTGIQKEDKYKIKQIMHHFIPDLLFAQRGDLSDVEEEEEE
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE1 EMDVDEATGAVKKHNGVGGSPPKSKLLFSNTAAQKLRGMDEVYNLFYVNNNWYIFMRLHQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EMDVDEATGAVKKHNGVGGSPPKSKLLFSNTAAQKLRGMDEVYNLFYVNNNWYIFMRLHQ
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE1 ILCLRLLRICSQAERQIEEENREREWEREVLGIKRDKSDSPAIQLRLKEPMDVDVEDYYP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ILCLRLLRICSQAERQIEEENREREWEREVLGIKRDKSDSPAIQLRLKEPMDVDVEDYYP
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE1 AFLDMVRSLLDGNIDSSQYEDSLREMFTIHAYIAFTMDKLIQSIVRQLQHIVSDEICVQV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 AFLDMVRSLLDGNIDSSQYEDSLREMFTIHAYIAFTMDKLIQSIVRQLQHIVSDEICVQV
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KE1 TDLYLAENNNGATGGQLNTQNSRSLLESTYQRKAEQLMSDENCFKLMFIQSQGQVQLTIE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 TDLYLAENNNGATGGQLNTQNSRSLLESTYQRKAEQLMSDENCFKLMFIQSQGQVQLTIE
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KE1 LLDTEEENSDDPVEAERWSDYVERYMNSDTTSPELREHLAQKPVFLPRNLRRIRKCQRGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LLDTEEENSDDPVEAERWSDYVERYMNSDTTSPELREHLAQKPVFLPRNLRRIRKCQRGR
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KE1 EQQEKEGKEGNSKKTMENVDSLDKLECRFKLNSYKMVYVIKSEDYMYRRTALLRAHQSHE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EQQEKEGKEGNSKKTMENVDSLDKLECRFKLNSYKMVYVIKSEDYMYRRTALLRAHQSHE
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KE1 RVSKRLHQRFQAWVDKWTKEHVPREMAAETSKWLMGEGLEGLVPCTTTCDTETLHFVSIN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 RVSKRLHQRFQAWVDKWTKEHVPREMAAETSKWLMGEGLEGLVPCTTTCDTETLHFVSIN
1210 1220 1230 1240 1250 1260
1270
pF1KE1 KYRVKYGTVFKAP
:::::::::::::
XP_006 KYRVKYGTVFKAP
1270
>>XP_006720528 (OMIM: 607776,613406) PREDICTED: paired a (1273 aa)
initn: 8502 init1: 8502 opt: 8502 Z-score: 3559.8 bits: 670.9 E(85289): 1.5e-191
Smith-Waterman score: 8502; 99.9% identity (100.0% similar) in 1273 aa overlap (1-1273:1-1273)
10 20 30 40 50 60
pF1KE1 MKRRLDDQESPVYAAQQRRIPGSTEAFPHQHRVLAPAPPVYEAVSETMQSATGIQYSVTP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 MKRRLDDQESPVYAAQQRRIPGSTEAFPHQHRVLAPAPPVYEAVSETMQSATGIQYSVTP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 SYQVSAMPQSSGSHGPAIAAVHSSHHHPTAVQPHGGQVVQSHAHPAPPAAPVQGQQQFQR
::::::::::::::::::::::::::::::::::::::::::::::::.:::::::::::
XP_006 SYQVSAMPQSSGSHGPAIAAVHSSHHHPTAVQPHGGQVVQSHAHPAPPVAPVQGQQQFQR
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 LKVEDALSYLDQVKLQFGSQPQVYNDFLDIMKEFKSQSIDTPGVISRVSQLFKGHPDLIM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LKVEDALSYLDQVKLQFGSQPQVYNDFLDIMKEFKSQSIDTPGVISRVSQLFKGHPDLIM
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE1 GFNTFLPPGYKIEVQTNDMVNVTTPGQVHQIPTHGIQPQPQPPPQHPSQPSAQSAPAPAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GFNTFLPPGYKIEVQTNDMVNVTTPGQVHQIPTHGIQPQPQPPPQHPSQPSAQSAPAPAQ
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE1 PAPQPPPAKVSKPSQLQAHTPASQQTPPLPPYASPRSPPVQPHTPVTISLGTAPSLQNNQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PAPQPPPAKVSKPSQLQAHTPASQQTPPLPPYASPRSPPVQPHTPVTISLGTAPSLQNNQ
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE1 PVEFNHAINYVNKIKNRFQGQPDIYKAFLEILHTYQKEQRNAKEAGGNYTPALTEQEVYA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PVEFNHAINYVNKIKNRFQGQPDIYKAFLEILHTYQKEQRNAKEAGGNYTPALTEQEVYA
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE1 QVARLFKNQEDLLSEFGQFLPDANSSVLLSKTTAEKVDSVRNDHGGTVKKPQLNNKPQRP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 QVARLFKNQEDLLSEFGQFLPDANSSVLLSKTTAEKVDSVRNDHGGTVKKPQLNNKPQRP
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE1 SQNGCQIRRHPTGTTPPVKKKPKLLNLKDSSMADASKHGGGTESLFFDKVRKALRSAEAY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SQNGCQIRRHPTGTTPPVKKKPKLLNLKDSSMADASKHGGGTESLFFDKVRKALRSAEAY
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE1 ENFLRCLVIFNQEVISRAELVQLVSPFLGKFPELFNWFKNFLGYKESVHLETYPKERATE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ENFLRCLVIFNQEVISRAELVQLVSPFLGKFPELFNWFKNFLGYKESVHLETYPKERATE
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE1 GIAMEIDYASCKRLGSSYRALPKSYQQPKCTGRTPLCKEVLNDTWVSFPSWSEDSTFVSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GIAMEIDYASCKRLGSSYRALPKSYQQPKCTGRTPLCKEVLNDTWVSFPSWSEDSTFVSS
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE1 KKTQYEEHIYRCEDERFELDVVLETNLATIRVLEAIQKKLSRLSAEEQAKFRLDNTLGGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 KKTQYEEHIYRCEDERFELDVVLETNLATIRVLEAIQKKLSRLSAEEQAKFRLDNTLGGT
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE1 SEVIHRKALQRIYADKAADIIDGLRKNPSIAVPIVLKRLKMKEEEWREAQRGFNKVWREQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SEVIHRKALQRIYADKAADIIDGLRKNPSIAVPIVLKRLKMKEEEWREAQRGFNKVWREQ
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE1 NEKYYLKSLDHQGINFKQNDTKVLRSKSLLNEIESIYDERQEQATEENAGVPVGPHLSLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 NEKYYLKSLDHQGINFKQNDTKVLRSKSLLNEIESIYDERQEQATEENAGVPVGPHLSLA
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE1 YEDKQILEDAAALIIHHVKRQTGIQKEDKYKIKQIMHHFIPDLLFAQRGDLSDVEEEEEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 YEDKQILEDAAALIIHHVKRQTGIQKEDKYKIKQIMHHFIPDLLFAQRGDLSDVEEEEEE
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE1 EMDVDEATGAVKKHNGVGGSPPKSKLLFSNTAAQKLRGMDEVYNLFYVNNNWYIFMRLHQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EMDVDEATGAVKKHNGVGGSPPKSKLLFSNTAAQKLRGMDEVYNLFYVNNNWYIFMRLHQ
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE1 ILCLRLLRICSQAERQIEEENREREWEREVLGIKRDKSDSPAIQLRLKEPMDVDVEDYYP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ILCLRLLRICSQAERQIEEENREREWEREVLGIKRDKSDSPAIQLRLKEPMDVDVEDYYP
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE1 AFLDMVRSLLDGNIDSSQYEDSLREMFTIHAYIAFTMDKLIQSIVRQLQHIVSDEICVQV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 AFLDMVRSLLDGNIDSSQYEDSLREMFTIHAYIAFTMDKLIQSIVRQLQHIVSDEICVQV
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KE1 TDLYLAENNNGATGGQLNTQNSRSLLESTYQRKAEQLMSDENCFKLMFIQSQGQVQLTIE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 TDLYLAENNNGATGGQLNTQNSRSLLESTYQRKAEQLMSDENCFKLMFIQSQGQVQLTIE
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KE1 LLDTEEENSDDPVEAERWSDYVERYMNSDTTSPELREHLAQKPVFLPRNLRRIRKCQRGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LLDTEEENSDDPVEAERWSDYVERYMNSDTTSPELREHLAQKPVFLPRNLRRIRKCQRGR
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KE1 EQQEKEGKEGNSKKTMENVDSLDKLECRFKLNSYKMVYVIKSEDYMYRRTALLRAHQSHE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EQQEKEGKEGNSKKTMENVDSLDKLECRFKLNSYKMVYVIKSEDYMYRRTALLRAHQSHE
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KE1 RVSKRLHQRFQAWVDKWTKEHVPREMAAETSKWLMGEGLEGLVPCTTTCDTETLHFVSIN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 RVSKRLHQRFQAWVDKWTKEHVPREMAAETSKWLMGEGLEGLVPCTTTCDTETLHFVSIN
1210 1220 1230 1240 1250 1260
1270
pF1KE1 KYRVKYGTVFKAP
:::::::::::::
XP_006 KYRVKYGTVFKAP
1270
>>NP_001138829 (OMIM: 607776,613406) paired amphipathic (1273 aa)
initn: 8502 init1: 8502 opt: 8502 Z-score: 3559.8 bits: 670.9 E(85289): 1.5e-191
Smith-Waterman score: 8502; 99.9% identity (100.0% similar) in 1273 aa overlap (1-1273:1-1273)
10 20 30 40 50 60
pF1KE1 MKRRLDDQESPVYAAQQRRIPGSTEAFPHQHRVLAPAPPVYEAVSETMQSATGIQYSVTP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MKRRLDDQESPVYAAQQRRIPGSTEAFPHQHRVLAPAPPVYEAVSETMQSATGIQYSVTP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 SYQVSAMPQSSGSHGPAIAAVHSSHHHPTAVQPHGGQVVQSHAHPAPPAAPVQGQQQFQR
::::::::::::::::::::::::::::::::::::::::::::::::.:::::::::::
NP_001 SYQVSAMPQSSGSHGPAIAAVHSSHHHPTAVQPHGGQVVQSHAHPAPPVAPVQGQQQFQR
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 LKVEDALSYLDQVKLQFGSQPQVYNDFLDIMKEFKSQSIDTPGVISRVSQLFKGHPDLIM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LKVEDALSYLDQVKLQFGSQPQVYNDFLDIMKEFKSQSIDTPGVISRVSQLFKGHPDLIM
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE1 GFNTFLPPGYKIEVQTNDMVNVTTPGQVHQIPTHGIQPQPQPPPQHPSQPSAQSAPAPAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GFNTFLPPGYKIEVQTNDMVNVTTPGQVHQIPTHGIQPQPQPPPQHPSQPSAQSAPAPAQ
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE1 PAPQPPPAKVSKPSQLQAHTPASQQTPPLPPYASPRSPPVQPHTPVTISLGTAPSLQNNQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PAPQPPPAKVSKPSQLQAHTPASQQTPPLPPYASPRSPPVQPHTPVTISLGTAPSLQNNQ
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE1 PVEFNHAINYVNKIKNRFQGQPDIYKAFLEILHTYQKEQRNAKEAGGNYTPALTEQEVYA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PVEFNHAINYVNKIKNRFQGQPDIYKAFLEILHTYQKEQRNAKEAGGNYTPALTEQEVYA
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE1 QVARLFKNQEDLLSEFGQFLPDANSSVLLSKTTAEKVDSVRNDHGGTVKKPQLNNKPQRP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QVARLFKNQEDLLSEFGQFLPDANSSVLLSKTTAEKVDSVRNDHGGTVKKPQLNNKPQRP
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE1 SQNGCQIRRHPTGTTPPVKKKPKLLNLKDSSMADASKHGGGTESLFFDKVRKALRSAEAY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SQNGCQIRRHPTGTTPPVKKKPKLLNLKDSSMADASKHGGGTESLFFDKVRKALRSAEAY
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE1 ENFLRCLVIFNQEVISRAELVQLVSPFLGKFPELFNWFKNFLGYKESVHLETYPKERATE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ENFLRCLVIFNQEVISRAELVQLVSPFLGKFPELFNWFKNFLGYKESVHLETYPKERATE
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE1 GIAMEIDYASCKRLGSSYRALPKSYQQPKCTGRTPLCKEVLNDTWVSFPSWSEDSTFVSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GIAMEIDYASCKRLGSSYRALPKSYQQPKCTGRTPLCKEVLNDTWVSFPSWSEDSTFVSS
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE1 KKTQYEEHIYRCEDERFELDVVLETNLATIRVLEAIQKKLSRLSAEEQAKFRLDNTLGGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KKTQYEEHIYRCEDERFELDVVLETNLATIRVLEAIQKKLSRLSAEEQAKFRLDNTLGGT
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE1 SEVIHRKALQRIYADKAADIIDGLRKNPSIAVPIVLKRLKMKEEEWREAQRGFNKVWREQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SEVIHRKALQRIYADKAADIIDGLRKNPSIAVPIVLKRLKMKEEEWREAQRGFNKVWREQ
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE1 NEKYYLKSLDHQGINFKQNDTKVLRSKSLLNEIESIYDERQEQATEENAGVPVGPHLSLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NEKYYLKSLDHQGINFKQNDTKVLRSKSLLNEIESIYDERQEQATEENAGVPVGPHLSLA
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE1 YEDKQILEDAAALIIHHVKRQTGIQKEDKYKIKQIMHHFIPDLLFAQRGDLSDVEEEEEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YEDKQILEDAAALIIHHVKRQTGIQKEDKYKIKQIMHHFIPDLLFAQRGDLSDVEEEEEE
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE1 EMDVDEATGAVKKHNGVGGSPPKSKLLFSNTAAQKLRGMDEVYNLFYVNNNWYIFMRLHQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EMDVDEATGAVKKHNGVGGSPPKSKLLFSNTAAQKLRGMDEVYNLFYVNNNWYIFMRLHQ
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE1 ILCLRLLRICSQAERQIEEENREREWEREVLGIKRDKSDSPAIQLRLKEPMDVDVEDYYP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ILCLRLLRICSQAERQIEEENREREWEREVLGIKRDKSDSPAIQLRLKEPMDVDVEDYYP
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE1 AFLDMVRSLLDGNIDSSQYEDSLREMFTIHAYIAFTMDKLIQSIVRQLQHIVSDEICVQV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AFLDMVRSLLDGNIDSSQYEDSLREMFTIHAYIAFTMDKLIQSIVRQLQHIVSDEICVQV
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KE1 TDLYLAENNNGATGGQLNTQNSRSLLESTYQRKAEQLMSDENCFKLMFIQSQGQVQLTIE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TDLYLAENNNGATGGQLNTQNSRSLLESTYQRKAEQLMSDENCFKLMFIQSQGQVQLTIE
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KE1 LLDTEEENSDDPVEAERWSDYVERYMNSDTTSPELREHLAQKPVFLPRNLRRIRKCQRGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LLDTEEENSDDPVEAERWSDYVERYMNSDTTSPELREHLAQKPVFLPRNLRRIRKCQRGR
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KE1 EQQEKEGKEGNSKKTMENVDSLDKLECRFKLNSYKMVYVIKSEDYMYRRTALLRAHQSHE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EQQEKEGKEGNSKKTMENVDSLDKLECRFKLNSYKMVYVIKSEDYMYRRTALLRAHQSHE
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KE1 RVSKRLHQRFQAWVDKWTKEHVPREMAAETSKWLMGEGLEGLVPCTTTCDTETLHFVSIN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RVSKRLHQRFQAWVDKWTKEHVPREMAAETSKWLMGEGLEGLVPCTTTCDTETLHFVSIN
1210 1220 1230 1240 1250 1260
1270
pF1KE1 KYRVKYGTVFKAP
:::::::::::::
NP_001 KYRVKYGTVFKAP
1270
>>XP_006720530 (OMIM: 607776,613406) PREDICTED: paired a (1273 aa)
initn: 8502 init1: 8502 opt: 8502 Z-score: 3559.8 bits: 670.9 E(85289): 1.5e-191
Smith-Waterman score: 8502; 99.9% identity (100.0% similar) in 1273 aa overlap (1-1273:1-1273)
10 20 30 40 50 60
pF1KE1 MKRRLDDQESPVYAAQQRRIPGSTEAFPHQHRVLAPAPPVYEAVSETMQSATGIQYSVTP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 MKRRLDDQESPVYAAQQRRIPGSTEAFPHQHRVLAPAPPVYEAVSETMQSATGIQYSVTP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 SYQVSAMPQSSGSHGPAIAAVHSSHHHPTAVQPHGGQVVQSHAHPAPPAAPVQGQQQFQR
::::::::::::::::::::::::::::::::::::::::::::::::.:::::::::::
XP_006 SYQVSAMPQSSGSHGPAIAAVHSSHHHPTAVQPHGGQVVQSHAHPAPPVAPVQGQQQFQR
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 LKVEDALSYLDQVKLQFGSQPQVYNDFLDIMKEFKSQSIDTPGVISRVSQLFKGHPDLIM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LKVEDALSYLDQVKLQFGSQPQVYNDFLDIMKEFKSQSIDTPGVISRVSQLFKGHPDLIM
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE1 GFNTFLPPGYKIEVQTNDMVNVTTPGQVHQIPTHGIQPQPQPPPQHPSQPSAQSAPAPAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GFNTFLPPGYKIEVQTNDMVNVTTPGQVHQIPTHGIQPQPQPPPQHPSQPSAQSAPAPAQ
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE1 PAPQPPPAKVSKPSQLQAHTPASQQTPPLPPYASPRSPPVQPHTPVTISLGTAPSLQNNQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PAPQPPPAKVSKPSQLQAHTPASQQTPPLPPYASPRSPPVQPHTPVTISLGTAPSLQNNQ
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE1 PVEFNHAINYVNKIKNRFQGQPDIYKAFLEILHTYQKEQRNAKEAGGNYTPALTEQEVYA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PVEFNHAINYVNKIKNRFQGQPDIYKAFLEILHTYQKEQRNAKEAGGNYTPALTEQEVYA
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE1 QVARLFKNQEDLLSEFGQFLPDANSSVLLSKTTAEKVDSVRNDHGGTVKKPQLNNKPQRP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 QVARLFKNQEDLLSEFGQFLPDANSSVLLSKTTAEKVDSVRNDHGGTVKKPQLNNKPQRP
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE1 SQNGCQIRRHPTGTTPPVKKKPKLLNLKDSSMADASKHGGGTESLFFDKVRKALRSAEAY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SQNGCQIRRHPTGTTPPVKKKPKLLNLKDSSMADASKHGGGTESLFFDKVRKALRSAEAY
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE1 ENFLRCLVIFNQEVISRAELVQLVSPFLGKFPELFNWFKNFLGYKESVHLETYPKERATE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ENFLRCLVIFNQEVISRAELVQLVSPFLGKFPELFNWFKNFLGYKESVHLETYPKERATE
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE1 GIAMEIDYASCKRLGSSYRALPKSYQQPKCTGRTPLCKEVLNDTWVSFPSWSEDSTFVSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GIAMEIDYASCKRLGSSYRALPKSYQQPKCTGRTPLCKEVLNDTWVSFPSWSEDSTFVSS
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE1 KKTQYEEHIYRCEDERFELDVVLETNLATIRVLEAIQKKLSRLSAEEQAKFRLDNTLGGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 KKTQYEEHIYRCEDERFELDVVLETNLATIRVLEAIQKKLSRLSAEEQAKFRLDNTLGGT
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE1 SEVIHRKALQRIYADKAADIIDGLRKNPSIAVPIVLKRLKMKEEEWREAQRGFNKVWREQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SEVIHRKALQRIYADKAADIIDGLRKNPSIAVPIVLKRLKMKEEEWREAQRGFNKVWREQ
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE1 NEKYYLKSLDHQGINFKQNDTKVLRSKSLLNEIESIYDERQEQATEENAGVPVGPHLSLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 NEKYYLKSLDHQGINFKQNDTKVLRSKSLLNEIESIYDERQEQATEENAGVPVGPHLSLA
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE1 YEDKQILEDAAALIIHHVKRQTGIQKEDKYKIKQIMHHFIPDLLFAQRGDLSDVEEEEEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 YEDKQILEDAAALIIHHVKRQTGIQKEDKYKIKQIMHHFIPDLLFAQRGDLSDVEEEEEE
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE1 EMDVDEATGAVKKHNGVGGSPPKSKLLFSNTAAQKLRGMDEVYNLFYVNNNWYIFMRLHQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EMDVDEATGAVKKHNGVGGSPPKSKLLFSNTAAQKLRGMDEVYNLFYVNNNWYIFMRLHQ
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE1 ILCLRLLRICSQAERQIEEENREREWEREVLGIKRDKSDSPAIQLRLKEPMDVDVEDYYP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ILCLRLLRICSQAERQIEEENREREWEREVLGIKRDKSDSPAIQLRLKEPMDVDVEDYYP
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE1 AFLDMVRSLLDGNIDSSQYEDSLREMFTIHAYIAFTMDKLIQSIVRQLQHIVSDEICVQV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 AFLDMVRSLLDGNIDSSQYEDSLREMFTIHAYIAFTMDKLIQSIVRQLQHIVSDEICVQV
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KE1 TDLYLAENNNGATGGQLNTQNSRSLLESTYQRKAEQLMSDENCFKLMFIQSQGQVQLTIE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 TDLYLAENNNGATGGQLNTQNSRSLLESTYQRKAEQLMSDENCFKLMFIQSQGQVQLTIE
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KE1 LLDTEEENSDDPVEAERWSDYVERYMNSDTTSPELREHLAQKPVFLPRNLRRIRKCQRGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LLDTEEENSDDPVEAERWSDYVERYMNSDTTSPELREHLAQKPVFLPRNLRRIRKCQRGR
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KE1 EQQEKEGKEGNSKKTMENVDSLDKLECRFKLNSYKMVYVIKSEDYMYRRTALLRAHQSHE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EQQEKEGKEGNSKKTMENVDSLDKLECRFKLNSYKMVYVIKSEDYMYRRTALLRAHQSHE
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KE1 RVSKRLHQRFQAWVDKWTKEHVPREMAAETSKWLMGEGLEGLVPCTTTCDTETLHFVSIN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 RVSKRLHQRFQAWVDKWTKEHVPREMAAETSKWLMGEGLEGLVPCTTTCDTETLHFVSIN
1210 1220 1230 1240 1250 1260
1270
pF1KE1 KYRVKYGTVFKAP
:::::::::::::
XP_006 KYRVKYGTVFKAP
1270
>>NP_001284524 (OMIM: 607777) paired amphipathic helix p (1130 aa)
initn: 3914 init1: 1503 opt: 1885 Z-score: 806.3 bits: 161.2 E(85289): 3.6e-38
Smith-Waterman score: 3872; 52.5% identity (75.9% similar) in 1174 aa overlap (114-1273:33-1130)
90 100 110 120 130 140
pF1KE1 SHHHPTAVQPHGGQVVQSHAHPAPPAAPVQGQQQFQRLKVEDALSYLDQVKLQFGSQPQV
:.... ..:::::.::::::..:::.: .
NP_001 HAGGGSGGSGAGGPAGRGLSGARWGRSGSAGHEKLP-VHVEDALTYLDQVKIRFGSDPAT
10 20 30 40 50 60
150 160 170 180 190 200
pF1KE1 YNDFLDIMKEFKSQSIDTPGVISRVSQLFKGHPDLIMGFNTFLPPGYKIEVQTNDMVNVT
:: ::.:::::::::::::::: ::::::. :::::.:::.::: ::.:.. : .:.
NP_001 YNGFLEIMKEFKSQSIDTPGVIRRVSQLFHEHPDLIVGFNAFLPLGYRIDIPKNGKLNIQ
70 80 90 100 110 120
210 220 230 240 250 260
pF1KE1 TPGQVHQIPTHGIQPQPQPPPQHPSQPSAQSAPAPAQPAPQPPPAKVSKPSQLQAHTPAS
.: :: .... :. : : : .::
NP_001 SP--------------------LTSQENSHNHGDGAEDFKQQVPYKEDKP----------
130 140 150
270 280 290 300 310 320
pF1KE1 QQTPPLPPYASPRSPPVQPHTPVTISLGTAPSLQNNQPVEFNHAINYVNKIKNRFQGQPD
:.: :.... ::::.::.::::::.:: .:.
NP_001 -QVP----------------------------LESDS-VEFNNAISYVNKIKTRFLDHPE
160 170 180
330 340 350 360 370 380
pF1KE1 IYKAFLEILHTYQKEQRNAKEAGGNYTPALTEQEVYAQVARLFKNQEDLLSEFGQFLPDA
::..:::::::::::: :.. : ...:.::...:: ::..:::::::::::::.:
NP_001 IYRSFLEILHTYQKEQLNTR---GRPFRGMSEEEVFTEVANLFRGQEDLLSEFGQFLPEA
190 200 210 220 230
390 400 410 420 430 440
pF1KE1 NSSVLLSKTTAEKVDSVRNDHGGTVKKPQLNNKPQRPSQNGCQIRRHPTGTTPPVKKKPK
. :.. .. : . .:.: : :. . : .::: .: :. . :.::: :
NP_001 KRSLFTGNGPCEMHSVQKNEHD---KTPEHSRKRSRPS----LLR--PV--SAPAKKKMK
240 250 260 270 280
450 460 470 480 490 500
pF1KE1 LLNLKDSSMADASKHGGGTESLFFDKVRKALRSAEAYENFLRCLVIFNQEVISRAELVQL
: . :: :.: ..:.: : ::::::..:.: :.:::::::...::::..: .::.::
NP_001 LRGTKDLSIAAVGKYGTLQEFSFFDKVRRVLKSQEVYENFLRCIALFNQELVSGSELLQL
290 300 310 320 330 340
510 520 530 540 550 560
pF1KE1 VSPFLGKFPELFNWFKNFLGYKESVHLETYPKERATEGIAMEIDYASCKRLGSSYRALPK
:::::::::::: ::.::: :: . . ..:. .::. :::::::::.:::::::::
NP_001 VSPFLGKFPELFAQFKSFLGVKE-LSFAPPMSDRSGDGISREIDYASCKRIGSSYRALPK
350 360 370 380 390 400
570 580 590 600 610 620
pF1KE1 SYQQPKCTGRTPLCKEVLNDTWVSFPSWSEDSTFVSSKKTQYEEHIYRCEDERFELDVVL
.::::::.::: .::::::::::::::::::::::::::: :::...:::::::::::::
NP_001 TYQQPKCSGRTAICKEVLNDTWVSFPSWSEDSTFVSSKKTPYEEQLHRCEDERFELDVVL
410 420 430 440 450 460
630 640 650 660 670 680
pF1KE1 ETNLATIRVLEAIQKKLSRLSAEEQAKFRLDNTLGGTSEVIHRKALQRIYADKAADIIDG
:::::::::::..::::::.. :.: :::::..::::::::.:.:. :::.::: .::..
NP_001 ETNLATIRVLESVQKKLSRMAPEDQEKFRLDDSLGGTSEVIQRRAIYRIYGDKAPEIIES
470 480 490 500 510 520
690 700 710 720 730 740
pF1KE1 LRKNPSIAVPIVLKRLKMKEEEWREAQRGFNKVWREQNEKYYLKSLDHQGINFKQNDTKV
:.::: :::.:::::: :::::::::.::::.:::: :: ::::::::..::::::::.
NP_001 LKKNPVTAVPVVLKRLKAKEEEWREAQQGFNKIWREQYEKAYLKSLDHQAVNFKQNDTKA
530 540 550 560 570 580
750 760 770 780 790 800
pF1KE1 LRSKSLLNEIESIYDERQEQATEENAGVPVGPHLSLAYEDKQILEDAAALIIHHVKRQTG
::::::::::::.:::.::: .: .. ::: ..:::.:::::::::: ..:::: .
NP_001 LRSKSLLNEIESVYDEHQEQHSEGRSAPSSEPHLIFVYEDRQILEDAAALISYYVKRQPA
590 600 610 620 630 640
810 820 830 840 850
pF1KE1 IQKEDKYKIKQIMHHFIPDLLFAQRGDLSDVEEEEEEEMDVDEA--TGAVKKHNGVGG--
:::::. :.:..:.:.:.:.:.:. ::. :: .:. : .. : .... . :
NP_001 IQKEDQGTIHQLLHQFVPSLFFSQQLDLGASEESADEDRDSPQGQTTDPSERKKPAPGPH
650 660 670 680 690 700
860 870 880 890 900
pF1KE1 -SPPKSKLLFSNTAAQKL---------RGMDEVYNLFYVNNNWYIFMRLHQILCLRLLRI
:::. : :... : . . .:.::.::..:::::.:.:::: :: :::.:
NP_001 SSPPEEKGAFGDAPATEQPPLPPPAPHKPLDDVYSLFFANNNWYFFLRLHQTLCSRLLKI
710 720 730 740 750 760
910 920 930 940 950 960
pF1KE1 CSQAERQIEEENREREWEREVLGIKRDKSDSPAIQLRLKEPMDVDVEDYYPAFLDMVRSL
::..:. : :.: :. . .:.:...::..::::.: .:..:.::::::::::::
NP_001 YRQAQKQLLEYRTEKEREKLLCEGRREKGSDPAMELRLKQPSEVELEEYYPAFLDMVRSL
770 780 790 800 810 820
970 980 990 1000 1010 1020
pF1KE1 LDGNIDSSQYEDSLREMFTIHAYIAFTMDKLIQSIVRQLQHIVSDEICVQVTDLYLAENN
:.:.:: .::::.::::::::::..::::::.:.:.:::.:.:::..:..:..::: :..
NP_001 LEGSIDPTQYEDTLREMFTIHAYVGFTMDKLVQNIARQLHHLVSDDVCLKVVELYLNEKK
830 840 850 860 870 880
1030 1040 1050 1060 1070 1080
pF1KE1 NGATGGQLNTQNSRSLLESTYQRKAEQLMSDENCFKLMFIQSQGQVQLTIELLDTEEENS
::.::.:... :. :..:: :::. :.::::::.::.: .::: .::::::::: ..
NP_001 RGAAGGNLSSRCVRAARETSYQWKAERCMADENCFKVMFLQRKGQVIMTIELLDTEEAQT
890 900 910 920 930 940
1090 1100 1110 1120 1130 1140
pF1KE1 DDPVEAERWSDYVERYMNSDTTSPELREHLAQKPVFLPRNLRRIRKCQRGREQQEKEGKE
.::::... . :::.:.... .: : . ::::: :::...:. .... . .:.
NP_001 EDPVEVQHLARYVEQYVGTEGASSSPTEGFLLKPVFLQRNLKKFRRRWQSEQARALRGEA
950 960 970 980 990 1000
1150 1160 1170 1180 1190 1200
pF1KE1 GNSKKTMENVDSLDKLECRFKLNSYKMVYVIKSEDYMYRRTALLRAHQSHERVSKRLHQR
.: : . .:.: ..:::::...:::....:::::::: .: ::.: . : : ::.
NP_001 RSSWKRLVGVESACDVDCRFKLSTHKMVFIVNSEDYMYRRGTLCRAKQVQPLVLLRHHQH
1010 1020 1030 1040 1050 1060
1210 1220 1230 1240 1250 1260
pF1KE1 FQAWVDKWTKEHVPREMAAETSKWLMGEGLEGLVPCTTTCDTETLHFVSINKYRVKYGTV
:. : ..: ...: : :. .. ::::: : .::: : :.: .: . ...:::.:.
NP_001 FEEWHSRWLEDNVTVEAASLVQDWLMGEEDEDMVPCKTLCETVHVHGLPVTRYRVQYSRR
1070 1080 1090 1100 1110 1120
1270
pF1KE1 FKAP
.:
NP_001 PASP
1130
>>XP_006722767 (OMIM: 607777) PREDICTED: paired amphipat (645 aa)
initn: 2225 init1: 1360 opt: 1377 Z-score: 598.3 bits: 121.9 E(85289): 1.4e-26
Smith-Waterman score: 2242; 51.9% identity (79.2% similar) in 645 aa overlap (643-1273:1-645)
620 630 640 650 660 670
pF1KE1 EDERFELDVVLETNLATIRVLEAIQKKLSRLSAEEQAKFRLDNTLGGTSEVIHRKALQRI
.. :.: :::::..::::::::.:.:. ::
XP_006 MAPEDQEKFRLDDSLGGTSEVIQRRAIYRI
10 20 30
680 690 700 710 720 730
pF1KE1 YADKAADIIDGLRKNPSIAVPIVLKRLKMKEEEWREAQRGFNKVWREQNEKYYLKSLDHQ
:.::: .::..:.::: :::.:::::: :::::::::.::::.:::: :: ::::::::
XP_006 YGDKAPEIIESLKKNPVTAVPVVLKRLKAKEEEWREAQQGFNKIWREQYEKAYLKSLDHQ
40 50 60 70 80 90
740 750 760 770 780 790
pF1KE1 GINFKQNDTKVLRSKSLLNEIESIYDERQEQATEENAGVPVGPHLSLAYEDKQILEDAAA
..::::::::.::::::::::::.:::.::: .: .. ::: ..:::.::::::::
XP_006 AVNFKQNDTKALRSKSLLNEIESVYDEHQEQHSEGRSAPSSEPHLIFVYEDRQILEDAAA
100 110 120 130 140 150
800 810 820 830 840 850
pF1KE1 LIIHHVKRQTGIQKEDKYKIKQIMHHFIPDLLFAQRGDLSDVEEEEEEEMDVDEA--TGA
:: ..:::: .:::::. :.:..:.:.:.:.:.:. ::. :: .:. : .. :
XP_006 LISYYVKRQPAIQKEDQGTIHQLLHQFVPSLFFSQQLDLGASEESADEDRDSPQGQTTDP
160 170 180 190 200 210
860 870 880 890
pF1KE1 VKKHNGVGG---SPPKSKLLFSNTAAQKL---------RGMDEVYNLFYVNNNWYIFMRL
.... . : :::. : :... : . . .:.::.::..:::::.:.::
XP_006 SERKKPAPGPHSSPPEEKGAFGDAPATEQPPLPPPAPHKPLDDVYSLFFANNNWYFFLRL
220 230 240 250 260 270
900 910 920 930 940 950
pF1KE1 HQILCLRLLRICSQAERQIEEENREREWEREVLGIKRDKSDSPAIQLRLKEPMDVDVEDY
:: :: :::.: ::..:. : :.: :. . .:.:...::..::::.: .:..:.:
XP_006 HQTLCSRLLKIYRQAQKQLLEYRTEKEREKLLCEGRREKGSDPAMELRLKQPSEVELEEY
280 290 300 310 320 330
960 970 980 990 1000 1010
pF1KE1 YPAFLDMVRSLLDGNIDSSQYEDSLREMFTIHAYIAFTMDKLIQSIVRQLQHIVSDEICV
::::::::::::.:.:: .::::.::::::::::..::::::.:.:.:::.:.:::..:.
XP_006 YPAFLDMVRSLLEGSIDPTQYEDTLREMFTIHAYVGFTMDKLVQNIARQLHHLVSDDVCL
340 350 360 370 380 390
1020 1030 1040 1050 1060 1070
pF1KE1 QVTDLYLAENNNGATGGQLNTQNSRSLLESTYQRKAEQLMSDENCFKLMFIQSQGQVQLT
.:..::: :.. ::.::.:... :. :..:: :::. :.::::::.::.: .::: .:
XP_006 KVVELYLNEKKRGAAGGNLSSRCVRAARETSYQWKAERCMADENCFKVMFLQRKGQVIMT
400 410 420 430 440 450
1080 1090 1100 1110 1120 1130
pF1KE1 IELLDTEEENSDDPVEAERWSDYVERYMNSDTTSPELREHLAQKPVFLPRNLRRIRKCQR
:::::::: ...::::... . :::.:.... .: : . ::::: :::...:. .
XP_006 IELLDTEEAQTEDPVEVQHLARYVEQYVGTEGASSSPTEGFLLKPVFLQRNLKKFRRRWQ
460 470 480 490 500 510
1140 1150 1160 1170 1180 1190
pF1KE1 GREQQEKEGKEGNSKKTMENVDSLDKLECRFKLNSYKMVYVIKSEDYMYRRTALLRAHQS
... . .:. .: : . .:.: ..:::::...:::....:::::::: .: ::.:
XP_006 SEQARALRGEARSSWKRLVGVESACDVDCRFKLSTHKMVFIVNSEDYMYRRGTLCRAKQV
520 530 540 550 560 570
1200 1210 1220 1230 1240 1250
pF1KE1 HERVSKRLHQRFQAWVDKWTKEHVPREMAAETSKWLMGEGLEGLVPCTTTCDTETLHFVS
. : : ::.:. : ..: ...: : :. .. ::::: : .::: : :.: .: .
XP_006 QPLVLLRHHQHFEEWHSRWLEDNVTVEAASLVQDWLMGEEDEDMVPCKTLCETVHVHGLP
580 590 600 610 620 630
1260 1270
pF1KE1 INKYRVKYGTVFKAP
...:::.:. .:
XP_006 VTRYRVQYSRRPASP
640
>>NP_001284526 (OMIM: 607777) paired amphipathic helix p (720 aa)
initn: 2604 init1: 1360 opt: 1377 Z-score: 597.6 bits: 122.0 E(85289): 1.5e-26
Smith-Waterman score: 2622; 55.1% identity (80.6% similar) in 715 aa overlap (573-1273:6-720)
550 560 570 580 590 600
pF1KE1 AMEIDYASCKRLGSSYRALPKSYQQPKCTGRTPLCKEVLNDTWVSFPSWSEDSTFVSSKK
: : .:::::::::::::::::::::::
NP_001 MQRHSRHFLLVQVLNDTWVSFPSWSEDSTFVSSKK
10 20 30
610 620 630 640 650 660
pF1KE1 TQYEEHIYRCEDERFELDVVLETNLATIRVLEAIQKKLSRLSAEEQAKFRLDNTLGGTSE
: :::...::::::::::::::::::::::::..::::::.. :.: :::::..::::::
NP_001 TPYEEQLHRCEDERFELDVVLETNLATIRVLESVQKKLSRMAPEDQEKFRLDDSLGGTSE
40 50 60 70 80 90
670 680 690 700 710 720
pF1KE1 VIHRKALQRIYADKAADIIDGLRKNPSIAVPIVLKRLKMKEEEWREAQRGFNKVWREQNE
::.:.:. :::.::: .::..:.::: :::.:::::: :::::::::.::::.:::: :
NP_001 VIQRRAIYRIYGDKAPEIIESLKKNPVTAVPVVLKRLKAKEEEWREAQQGFNKIWREQYE
100 110 120 130 140 150
730 740 750 760 770 780
pF1KE1 KYYLKSLDHQGINFKQNDTKVLRSKSLLNEIESIYDERQEQATEENAGVPVGPHLSLAYE
: ::::::::..::::::::.::::::::::::.:::.::: .: .. ::: ..::
NP_001 KAYLKSLDHQAVNFKQNDTKALRSKSLLNEIESVYDEHQEQHSEGRSAPSSEPHLIFVYE
160 170 180 190 200 210
790 800 810 820 830 840
pF1KE1 DKQILEDAAALIIHHVKRQTGIQKEDKYKIKQIMHHFIPDLLFAQRGDLSDVEEEEEEEM
:.:::::::::: ..:::: .:::::. :.:..:.:.:.:.:.:. ::. :: .:.
NP_001 DRQILEDAAALISYYVKRQPAIQKEDQGTIHQLLHQFVPSLFFSQQLDLGASEESADEDR
220 230 240 250 260 270
850 860 870 880
pF1KE1 DVDEA--TGAVKKHNGVGG---SPPKSKLLFSNTAAQKL---------RGMDEVYNLFYV
: .. : .... . : :::. : :... : . . .:.::.::..
NP_001 DSPQGQTTDPSERKKPAPGPHSSPPEEKGAFGDAPATEQPPLPPPAPHKPLDDVYSLFFA
280 290 300 310 320 330
890 900 910 920 930 940
pF1KE1 NNNWYIFMRLHQILCLRLLRICSQAERQIEEENREREWEREVLGIKRDKSDSPAIQLRLK
:::::.:.:::: :: :::.: ::..:. : :.: :. . .:.:...::..::::
NP_001 NNNWYFFLRLHQTLCSRLLKIYRQAQKQLLEYRTEKEREKLLCEGRREKGSDPAMELRLK
340 350 360 370 380 390
950 960 970 980 990 1000
pF1KE1 EPMDVDVEDYYPAFLDMVRSLLDGNIDSSQYEDSLREMFTIHAYIAFTMDKLIQSIVRQL
.: .:..:.:::::::::::::.:.:: .::::.::::::::::..::::::.:.:.:::
NP_001 QPSEVELEEYYPAFLDMVRSLLEGSIDPTQYEDTLREMFTIHAYVGFTMDKLVQNIARQL
400 410 420 430 440 450
1010 1020 1030 1040 1050 1060
pF1KE1 QHIVSDEICVQVTDLYLAENNNGATGGQLNTQNSRSLLESTYQRKAEQLMSDENCFKLMF
.:.:::..:..:..::: :.. ::.::.:... :. :..:: :::. :.::::::.::
NP_001 HHLVSDDVCLKVVELYLNEKKRGAAGGNLSSRCVRAARETSYQWKAERCMADENCFKVMF
460 470 480 490 500 510
1070 1080 1090 1100 1110 1120
pF1KE1 IQSQGQVQLTIELLDTEEENSDDPVEAERWSDYVERYMNSDTTSPELREHLAQKPVFLPR
.: .::: .::::::::: ...::::... . :::.:.... .: : . ::::: :
NP_001 LQRKGQVIMTIELLDTEEAQTEDPVEVQHLARYVEQYVGTEGASSSPTEGFLLKPVFLQR
520 530 540 550 560 570
1130 1140 1150 1160 1170 1180
pF1KE1 NLRRIRKCQRGREQQEKEGKEGNSKKTMENVDSLDKLECRFKLNSYKMVYVIKSEDYMYR
::...:. .... . .:. .: : . .:.: ..:::::...:::....:::::::
NP_001 NLKKFRRRWQSEQARALRGEARSSWKRLVGVESACDVDCRFKLSTHKMVFIVNSEDYMYR
580 590 600 610 620 630
1190 1200 1210 1220 1230 1240
pF1KE1 RTALLRAHQSHERVSKRLHQRFQAWVDKWTKEHVPREMAAETSKWLMGEGLEGLVPCTTT
: .: ::.: . : : ::.:. : ..: ...: : :. .. ::::: : .::: :
NP_001 RGTLCRAKQVQPLVLLRHHQHFEEWHSRWLEDNVTVEAASLVQDWLMGEEDEDMVPCKTL
640 650 660 670 680 690
1250 1260 1270
pF1KE1 CDTETLHFVSINKYRVKYGTVFKAP
:.: .: . ...:::.:. .:
NP_001 CETVHVHGLPVTRYRVQYSRRPASP
700 710 720
>>NP_056075 (OMIM: 607777) paired amphipathic helix prot (1162 aa)
initn: 3891 init1: 1360 opt: 1377 Z-score: 594.6 bits: 122.1 E(85289): 2.2e-26
Smith-Waterman score: 3798; 51.1% identity (73.9% similar) in 1206 aa overlap (114-1273:33-1162)
90 100 110 120 130 140
pF1KE1 SHHHPTAVQPHGGQVVQSHAHPAPPAAPVQGQQQFQRLKVEDALSYLDQVKLQFGSQPQV
:.... ..:::::.::::::..:::.: .
NP_056 HAGGGSGGSGAGGPAGRGLSGARWGRSGSAGHEKLP-VHVEDALTYLDQVKIRFGSDPAT
10 20 30 40 50 60
150 160 170 180 190 200
pF1KE1 YNDFLDIMKEFKSQSIDTPGVISRVSQLFKGHPDLIMGFNTFLPPGYKIEVQTNDMVNVT
:: ::.:::::::::::::::: ::::::. :::::.:::.::: ::.:.. : .:.
NP_056 YNGFLEIMKEFKSQSIDTPGVIRRVSQLFHEHPDLIVGFNAFLPLGYRIDIPKNGKLNIQ
70 80 90 100 110 120
210 220 230 240 250 260
pF1KE1 TPGQVHQIPTHGIQPQPQPPPQHPSQPSAQSAPAPAQPAPQPPPAKVSKPSQLQAHTPAS
.: :: .... :. : : : .::
NP_056 SP--------------------LTSQENSHNHGDGAEDFKQQVPYKEDKP----------
130 140 150
270 280 290 300 310 320
pF1KE1 QQTPPLPPYASPRSPPVQPHTPVTISLGTAPSLQNNQPVEFNHAINYVNKIKNRFQGQPD
:.: :.... ::::.::.::::::.:: .:.
NP_056 -QVP----------------------------LESDS-VEFNNAISYVNKIKTRFLDHPE
160 170 180
330 340 350 360 370 380
pF1KE1 IYKAFLEILHTYQKEQRNAKEAGGNYTPALTEQEVYAQVARLFKNQEDLLSEFGQFLPDA
::..:::::::::::: :.. : ...:.::...:: ::..:::::::::::::.:
NP_056 IYRSFLEILHTYQKEQLNTR---GRPFRGMSEEEVFTEVANLFRGQEDLLSEFGQFLPEA
190 200 210 220 230
390 400 410 420 430 440
pF1KE1 NSSVLLSKTTAEKVDSVRNDHGGTVKKPQLNNKPQRPSQNGCQIRRHPTGTTPPVKKKPK
. :.. .. : . .:.: : :. . : .::: .: :. . :.::: :
NP_056 KRSLFTGNGPCEMHSVQKNEHD---KTPEHSRKRSRPS----LLR--PV--SAPAKKKMK
240 250 260 270 280
450 460 470 480 490 500
pF1KE1 LLNLKDSSMADASKHGGGTESLFFDKVRKALRSAEAYENFLRCLVIFNQEVISRAELVQL
: . :: :.: ..:.: : ::::::..:.: :.:::::::...::::..: .::.::
NP_056 LRGTKDLSIAAVGKYGTLQEFSFFDKVRRVLKSQEVYENFLRCIALFNQELVSGSELLQL
290 300 310 320 330 340
510 520 530 540 550 560
pF1KE1 VSPFLGKFPELFNWFKNFLGYKESVHLETYPKERATEGIAMEIDYASCKRLGSSYRALPK
:::::::::::: ::.::: :: . . ..:. .::. :::::::::.:::::::::
NP_056 VSPFLGKFPELFAQFKSFLGVKE-LSFAPPMSDRSGDGISREIDYASCKRIGSSYRALPK
350 360 370 380 390 400
570 580 590
pF1KE1 SYQQPKCTGRTPLCKE--------------------------------VLNDTWVSFPSW
.::::::.::: .::: ::::::::::::
NP_056 TYQQPKCSGRTAICKELDHWTLLQGSWTDDYCMSKFKNTCWIPGYSAGVLNDTWVSFPSW
410 420 430 440 450 460
600 610 620 630 640 650
pF1KE1 SEDSTFVSSKKTQYEEHIYRCEDERFELDVVLETNLATIRVLEAIQKKLSRLSAEEQAKF
:::::::::::: :::...::::::::::::::::::::::::..::::::.. :.: ::
NP_056 SEDSTFVSSKKTPYEEQLHRCEDERFELDVVLETNLATIRVLESVQKKLSRMAPEDQEKF
470 480 490 500 510 520
660 670 680 690 700 710
pF1KE1 RLDNTLGGTSEVIHRKALQRIYADKAADIIDGLRKNPSIAVPIVLKRLKMKEEEWREAQR
:::..::::::::.:.:. :::.::: .::..:.::: :::.:::::: :::::::::.
NP_056 RLDDSLGGTSEVIQRRAIYRIYGDKAPEIIESLKKNPVTAVPVVLKRLKAKEEEWREAQQ
530 540 550 560 570 580
720 730 740 750 760 770
pF1KE1 GFNKVWREQNEKYYLKSLDHQGINFKQNDTKVLRSKSLLNEIESIYDERQEQATEENAGV
::::.:::: :: ::::::::..::::::::.::::::::::::.:::.::: .: ..
NP_056 GFNKIWREQYEKAYLKSLDHQAVNFKQNDTKALRSKSLLNEIESVYDEHQEQHSEGRSAP
590 600 610 620 630 640
780 790 800 810 820 830
pF1KE1 PVGPHLSLAYEDKQILEDAAALIIHHVKRQTGIQKEDKYKIKQIMHHFIPDLLFAQRGDL
::: ..:::.:::::::::: ..:::: .:::::. :.:..:.:.:.:.:.:. ::
NP_056 SSEPHLIFVYEDRQILEDAAALISYYVKRQPAIQKEDQGTIHQLLHQFVPSLFFSQQLDL
650 660 670 680 690 700
840 850 860 870
pF1KE1 SDVEEEEEEEMDVDEA--TGAVKKHNGVGG---SPPKSKLLFSNTAAQKL---------R
. :: .:. : .. : .... . : :::. : :... : . .
NP_056 GASEESADEDRDSPQGQTTDPSERKKPAPGPHSSPPEEKGAFGDAPATEQPPLPPPAPHK
710 720 730 740 750 760
880 890 900 910 920 930
pF1KE1 GMDEVYNLFYVNNNWYIFMRLHQILCLRLLRICSQAERQIEEENREREWEREVLGIKRDK
.:.::.::..:::::.:.:::: :: :::.: ::..:. : :.: :. . .:.:
NP_056 PLDDVYSLFFANNNWYFFLRLHQTLCSRLLKIYRQAQKQLLEYRTEKEREKLLCEGRREK
770 780 790 800 810 820
940 950 960 970 980 990
pF1KE1 SDSPAIQLRLKEPMDVDVEDYYPAFLDMVRSLLDGNIDSSQYEDSLREMFTIHAYIAFTM
...::..::::.: .:..:.:::::::::::::.:.:: .::::.::::::::::..:::
NP_056 GSDPAMELRLKQPSEVELEEYYPAFLDMVRSLLEGSIDPTQYEDTLREMFTIHAYVGFTM
830 840 850 860 870 880
1000 1010 1020 1030 1040 1050
pF1KE1 DKLIQSIVRQLQHIVSDEICVQVTDLYLAENNNGATGGQLNTQNSRSLLESTYQRKAEQL
:::.:.:.:::.:.:::..:..:..::: :.. ::.::.:... :. :..:: :::.
NP_056 DKLVQNIARQLHHLVSDDVCLKVVELYLNEKKRGAAGGNLSSRCVRAARETSYQWKAERC
890 900 910 920 930 940
1060 1070 1080 1090 1100 1110
pF1KE1 MSDENCFKLMFIQSQGQVQLTIELLDTEEENSDDPVEAERWSDYVERYMNSDTTSPELRE
:.::::::.::.: .::: .::::::::: ...::::... . :::.:.... .: :
NP_056 MADENCFKVMFLQRKGQVIMTIELLDTEEAQTEDPVEVQHLARYVEQYVGTEGASSSPTE
950 960 970 980 990 1000
1120 1130 1140 1150 1160 1170
pF1KE1 HLAQKPVFLPRNLRRIRKCQRGREQQEKEGKEGNSKKTMENVDSLDKLECRFKLNSYKMV
. ::::: :::...:. .... . .:. .: : . .:.: ..:::::...:::
NP_056 GFLLKPVFLQRNLKKFRRRWQSEQARALRGEARSSWKRLVGVESACDVDCRFKLSTHKMV
1010 1020 1030 1040 1050 1060
1180 1190 1200 1210 1220 1230
pF1KE1 YVIKSEDYMYRRTALLRAHQSHERVSKRLHQRFQAWVDKWTKEHVPREMAAETSKWLMGE
....:::::::: .: ::.: . : : ::.:. : ..: ...: : :. .. :::::
NP_056 FIVNSEDYMYRRGTLCRAKQVQPLVLLRHHQHFEEWHSRWLEDNVTVEAASLVQDWLMGE
1070 1080 1090 1100 1110 1120
1240 1250 1260 1270
pF1KE1 GLEGLVPCTTTCDTETLHFVSINKYRVKYGTVFKAP
: .::: : :.: .: . ...:::.:. .:
NP_056 EDEDMVPCKTLCETVHVHGLPVTRYRVQYSRRPASP
1130 1140 1150 1160
1273 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sat Nov 5 07:29:36 2016 done: Sat Nov 5 07:29:39 2016
Total Scan time: 17.790 Total Display time: 0.690
Function used was FASTA [36.3.4 Apr, 2011]