Result of FASTA (omim) for
pFN21AB4983
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB4983, 509 aa
1>>>pF1KB4983 509 - 509 aa - 509 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.2604+/-0.000509; mu= 18.1644+/- 0.031
mean_var=65.2055+/-13.274, 0's: 0 Z-trim(108.1): 47 B-trim: 629 in 2/48
Lambda= 0.158830
statistics sampled from 16179 (16213) to 16179 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.543), E-opt: 0.2 (0.19), width: 16
Scan time: 8.680
The best scores are: opt bits E(85289)
NP_000099 (OMIM: 238331,246900) dihydrolipoyl dehy ( 509) 3324 771.2 0
NP_001276680 (OMIM: 238331,246900) dihydrolipoyl d ( 486) 2725 633.9 3.1e-181
NP_001276679 (OMIM: 238331,246900) dihydrolipoyl d ( 410) 2649 616.5 4.7e-176
NP_001276681 (OMIM: 238331,246900) dihydrolipoyl d ( 461) 2052 479.7 7.8e-135
NP_000628 (OMIM: 138300) glutathione reductase, mi ( 522) 644 157.1 1.1e-37
NP_001248375 (OMIM: 601112) thioredoxin reductase ( 461) 601 147.2 9.6e-35
NP_877393 (OMIM: 601112) thioredoxin reductase 1, ( 499) 601 147.2 1e-34
NP_877420 (OMIM: 601112) thioredoxin reductase 1, ( 499) 601 147.2 1e-34
NP_877419 (OMIM: 601112) thioredoxin reductase 1, ( 499) 601 147.2 1e-34
NP_001248374 (OMIM: 601112) thioredoxin reductase ( 549) 601 147.3 1.1e-34
NP_003321 (OMIM: 601112) thioredoxin reductase 1, ( 551) 601 147.3 1.1e-34
NP_001087240 (OMIM: 601112) thioredoxin reductase ( 649) 601 147.3 1.3e-34
NP_006431 (OMIM: 606448) thioredoxin reductase 2, ( 524) 569 139.9 1.7e-32
NP_443115 (OMIM: 606235) thioredoxin reductase 3 i ( 643) 563 138.6 5.3e-32
NP_001182031 (OMIM: 138300) glutathione reductase, ( 493) 356 91.1 8e-18
NP_001269441 (OMIM: 606448) thioredoxin reductase ( 338) 326 84.1 6.9e-16
NP_001182033 (OMIM: 138300) glutathione reductase, ( 440) 311 80.8 9.3e-15
NP_001182032 (OMIM: 138300) glutathione reductase, ( 469) 307 79.9 1.9e-14
NP_001185625 (OMIM: 605159) apoptosis-inducing fac ( 373) 147 43.1 0.0017
NP_116186 (OMIM: 605159) apoptosis-inducing factor ( 373) 147 43.1 0.0017
>>NP_000099 (OMIM: 238331,246900) dihydrolipoyl dehydrog (509 aa)
initn: 3324 init1: 3324 opt: 3324 Z-score: 4116.3 bits: 771.2 E(85289): 0
Smith-Waterman score: 3324; 99.8% identity (100.0% similar) in 509 aa overlap (1-509:1-509)
10 20 30 40 50 60
pF1KB4 MQSWSRVYCSLAKRGHFNRISHGLQGLSAVPLRTYADQPIDADVTVIGSGPGGYVAAIKA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 MQSWSRVYCSLAKRGHFNRISHGLQGLSAVPLRTYADQPIDADVTVIGSGPGGYVAAIKA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB4 AQLGFKTVCIEKNETLGGTCLNVGCIPSKALLNNSHYYHMAHGKDFASRGIEMSEVRLNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 AQLGFKTVCIEKNETLGGTCLNVGCIPSKALLNNSHYYHMAHGKDFASRGIEMSEVRLNL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB4 DKMMEQKSTAVKALTGGIAHLFKQNKVVHVNGYGKITGKNQVTATKADGGTQVIDTKNIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 DKMMEQKSTAVKALTGGIAHLFKQNKVVHVNGYGKITGKNQVTATKADGGTQVIDTKNIL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB4 IATGSEVTPFPGITIDEDTIVSSTGALSFKKVPEKMVVIGAGVIGVELGSVWQRLGADVT
::::::::::::::::::::::::::::.:::::::::::::::::::::::::::::::
NP_000 IATGSEVTPFPGITIDEDTIVSSTGALSLKKVPEKMVVIGAGVIGVELGSVWQRLGADVT
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB4 AVEFLGHVGGVGIDMEISKNFQRILQKQGFKFKLNTKVTGATKKSDGKIDVSIEAASGGK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 AVEFLGHVGGVGIDMEISKNFQRILQKQGFKFKLNTKVTGATKKSDGKIDVSIEAASGGK
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB4 AEVITCDVLLVCIGRRPFTKNLGLEELGIELDPRGRIPVNTRFQTKIPNIYAIGDVVAGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 AEVITCDVLLVCIGRRPFTKNLGLEELGIELDPRGRIPVNTRFQTKIPNIYAIGDVVAGP
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB4 MLAHKAEDEGIICVEGMAGGAVHIDYNCVPSVIYTHPEVAWVGKSEEQLKEEGIEYKVGK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 MLAHKAEDEGIICVEGMAGGAVHIDYNCVPSVIYTHPEVAWVGKSEEQLKEEGIEYKVGK
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB4 FPFAANSRAKTNADTDGMVKILGQKSTDRVLGAHILGPGAGEMVNEAALALEYGASCEDI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 FPFAANSRAKTNADTDGMVKILGQKSTDRVLGAHILGPGAGEMVNEAALALEYGASCEDI
430 440 450 460 470 480
490 500
pF1KB4 ARVCHAHPTLSEAFREANLAASFGKSINF
:::::::::::::::::::::::::::::
NP_000 ARVCHAHPTLSEAFREANLAASFGKSINF
490 500
>>NP_001276680 (OMIM: 238331,246900) dihydrolipoyl dehyd (486 aa)
initn: 2725 init1: 2725 opt: 2725 Z-score: 3374.8 bits: 633.9 E(85289): 3.1e-181
Smith-Waterman score: 3107; 95.3% identity (95.5% similar) in 509 aa overlap (1-509:1-486)
10 20 30 40 50 60
pF1KB4 MQSWSRVYCSLAKRGHFNRISHGLQGLSAVPLRTYADQPIDADVTVIGSGPGGYVAAIKA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MQSWSRVYCSLAKRGHFNRISHGLQGLSAVPLRTYADQPIDADVTVIGSGPGGYVAAIKA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB4 AQLGFKTVCIEKNETLGGTCLNVGCIPSKALLNNSHYYHMAHGKDFASRGIEMSEVRLNL
:::::: :::::::::::::::::::::::::::::::
NP_001 AQLGFK-----------------------ALLNNSHYYHMAHGKDFASRGIEMSEVRLNL
70 80 90
130 140 150 160 170 180
pF1KB4 DKMMEQKSTAVKALTGGIAHLFKQNKVVHVNGYGKITGKNQVTATKADGGTQVIDTKNIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DKMMEQKSTAVKALTGGIAHLFKQNKVVHVNGYGKITGKNQVTATKADGGTQVIDTKNIL
100 110 120 130 140 150
190 200 210 220 230 240
pF1KB4 IATGSEVTPFPGITIDEDTIVSSTGALSFKKVPEKMVVIGAGVIGVELGSVWQRLGADVT
::::::::::::::::::::::::::::.:::::::::::::::::::::::::::::::
NP_001 IATGSEVTPFPGITIDEDTIVSSTGALSLKKVPEKMVVIGAGVIGVELGSVWQRLGADVT
160 170 180 190 200 210
250 260 270 280 290 300
pF1KB4 AVEFLGHVGGVGIDMEISKNFQRILQKQGFKFKLNTKVTGATKKSDGKIDVSIEAASGGK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AVEFLGHVGGVGIDMEISKNFQRILQKQGFKFKLNTKVTGATKKSDGKIDVSIEAASGGK
220 230 240 250 260 270
310 320 330 340 350 360
pF1KB4 AEVITCDVLLVCIGRRPFTKNLGLEELGIELDPRGRIPVNTRFQTKIPNIYAIGDVVAGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AEVITCDVLLVCIGRRPFTKNLGLEELGIELDPRGRIPVNTRFQTKIPNIYAIGDVVAGP
280 290 300 310 320 330
370 380 390 400 410 420
pF1KB4 MLAHKAEDEGIICVEGMAGGAVHIDYNCVPSVIYTHPEVAWVGKSEEQLKEEGIEYKVGK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MLAHKAEDEGIICVEGMAGGAVHIDYNCVPSVIYTHPEVAWVGKSEEQLKEEGIEYKVGK
340 350 360 370 380 390
430 440 450 460 470 480
pF1KB4 FPFAANSRAKTNADTDGMVKILGQKSTDRVLGAHILGPGAGEMVNEAALALEYGASCEDI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FPFAANSRAKTNADTDGMVKILGQKSTDRVLGAHILGPGAGEMVNEAALALEYGASCEDI
400 410 420 430 440 450
490 500
pF1KB4 ARVCHAHPTLSEAFREANLAASFGKSINF
:::::::::::::::::::::::::::::
NP_001 ARVCHAHPTLSEAFREANLAASFGKSINF
460 470 480
>>NP_001276679 (OMIM: 238331,246900) dihydrolipoyl dehyd (410 aa)
initn: 2649 init1: 2649 opt: 2649 Z-score: 3281.8 bits: 616.5 E(85289): 4.7e-176
Smith-Waterman score: 2649; 99.8% identity (100.0% similar) in 410 aa overlap (100-509:1-410)
70 80 90 100 110 120
pF1KB4 IEKNETLGGTCLNVGCIPSKALLNNSHYYHMAHGKDFASRGIEMSEVRLNLDKMMEQKST
::::::::::::::::::::::::::::::
NP_001 MAHGKDFASRGIEMSEVRLNLDKMMEQKST
10 20 30
130 140 150 160 170 180
pF1KB4 AVKALTGGIAHLFKQNKVVHVNGYGKITGKNQVTATKADGGTQVIDTKNILIATGSEVTP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AVKALTGGIAHLFKQNKVVHVNGYGKITGKNQVTATKADGGTQVIDTKNILIATGSEVTP
40 50 60 70 80 90
190 200 210 220 230 240
pF1KB4 FPGITIDEDTIVSSTGALSFKKVPEKMVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVG
:::::::::::::::::::.::::::::::::::::::::::::::::::::::::::::
NP_001 FPGITIDEDTIVSSTGALSLKKVPEKMVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVG
100 110 120 130 140 150
250 260 270 280 290 300
pF1KB4 GVGIDMEISKNFQRILQKQGFKFKLNTKVTGATKKSDGKIDVSIEAASGGKAEVITCDVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GVGIDMEISKNFQRILQKQGFKFKLNTKVTGATKKSDGKIDVSIEAASGGKAEVITCDVL
160 170 180 190 200 210
310 320 330 340 350 360
pF1KB4 LVCIGRRPFTKNLGLEELGIELDPRGRIPVNTRFQTKIPNIYAIGDVVAGPMLAHKAEDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LVCIGRRPFTKNLGLEELGIELDPRGRIPVNTRFQTKIPNIYAIGDVVAGPMLAHKAEDE
220 230 240 250 260 270
370 380 390 400 410 420
pF1KB4 GIICVEGMAGGAVHIDYNCVPSVIYTHPEVAWVGKSEEQLKEEGIEYKVGKFPFAANSRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GIICVEGMAGGAVHIDYNCVPSVIYTHPEVAWVGKSEEQLKEEGIEYKVGKFPFAANSRA
280 290 300 310 320 330
430 440 450 460 470 480
pF1KB4 KTNADTDGMVKILGQKSTDRVLGAHILGPGAGEMVNEAALALEYGASCEDIARVCHAHPT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KTNADTDGMVKILGQKSTDRVLGAHILGPGAGEMVNEAALALEYGASCEDIARVCHAHPT
340 350 360 370 380 390
490 500
pF1KB4 LSEAFREANLAASFGKSINF
::::::::::::::::::::
NP_001 LSEAFREANLAASFGKSINF
400 410
>>NP_001276681 (OMIM: 238331,246900) dihydrolipoyl dehyd (461 aa)
initn: 2052 init1: 2052 opt: 2052 Z-score: 2541.7 bits: 479.7 E(85289): 7.8e-135
Smith-Waterman score: 2915; 90.4% identity (90.6% similar) in 509 aa overlap (1-509:1-461)
10 20 30 40 50 60
pF1KB4 MQSWSRVYCSLAKRGHFNRISHGLQGLSAVPLRTYADQPIDADVTVIGSGPGGYVAAIKA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MQSWSRVYCSLAKRGHFNRISHGLQGLSAVPLRTYADQPIDADVTVIGSGPGGYVAAIKA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB4 AQLGFKTVCIEKNETLGGTCLNVGCIPSKALLNNSHYYHMAHGKDFASRGIEMSEVRLNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AQLGFKTVCIEKNETLGGTCLNVGCIPSKALLNNSHYYHMAHGKDFASRGIEMSEVRLNL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB4 DKMMEQKSTAVKALTGGIAHLFKQNKVVHVNGYGKITGKNQVTATKADGGTQVIDTKNIL
::::::::::::::::::::::::::
NP_001 DKMMEQKSTAVKALTGGIAHLFKQNK----------------------------------
130 140
190 200 210 220 230 240
pF1KB4 IATGSEVTPFPGITIDEDTIVSSTGALSFKKVPEKMVVIGAGVIGVELGSVWQRLGADVT
::::::::::::::.:::::::::::::::::::::::::::::::
NP_001 --------------IDEDTIVSSTGALSLKKVPEKMVVIGAGVIGVELGSVWQRLGADVT
150 160 170 180 190
250 260 270 280 290 300
pF1KB4 AVEFLGHVGGVGIDMEISKNFQRILQKQGFKFKLNTKVTGATKKSDGKIDVSIEAASGGK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AVEFLGHVGGVGIDMEISKNFQRILQKQGFKFKLNTKVTGATKKSDGKIDVSIEAASGGK
200 210 220 230 240 250
310 320 330 340 350 360
pF1KB4 AEVITCDVLLVCIGRRPFTKNLGLEELGIELDPRGRIPVNTRFQTKIPNIYAIGDVVAGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AEVITCDVLLVCIGRRPFTKNLGLEELGIELDPRGRIPVNTRFQTKIPNIYAIGDVVAGP
260 270 280 290 300 310
370 380 390 400 410 420
pF1KB4 MLAHKAEDEGIICVEGMAGGAVHIDYNCVPSVIYTHPEVAWVGKSEEQLKEEGIEYKVGK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MLAHKAEDEGIICVEGMAGGAVHIDYNCVPSVIYTHPEVAWVGKSEEQLKEEGIEYKVGK
320 330 340 350 360 370
430 440 450 460 470 480
pF1KB4 FPFAANSRAKTNADTDGMVKILGQKSTDRVLGAHILGPGAGEMVNEAALALEYGASCEDI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FPFAANSRAKTNADTDGMVKILGQKSTDRVLGAHILGPGAGEMVNEAALALEYGASCEDI
380 390 400 410 420 430
490 500
pF1KB4 ARVCHAHPTLSEAFREANLAASFGKSINF
:::::::::::::::::::::::::::::
NP_001 ARVCHAHPTLSEAFREANLAASFGKSINF
440 450 460
>>NP_000628 (OMIM: 138300) glutathione reductase, mitoch (522 aa)
initn: 519 init1: 146 opt: 644 Z-score: 797.2 bits: 157.1 E(85289): 1.1e-37
Smith-Waterman score: 644; 30.5% identity (63.3% similar) in 463 aa overlap (43-492:66-516)
20 30 40 50 60 70
pF1KB4 KRGHFNRISHGLQGLSAVPLRTYADQPIDADVTVIGSGPGGYVAAIKAAQLGFKTVCIEK
: :::.: :: ..: .::.:: ... .:.
NP_000 LTRALSRAMACRQEPQPQGPPPAAGAVASYDYLVIGGGSGGLASARRAAELGARAAVVES
40 50 60 70 80 90
80 90 100 110 120 130
pF1KB4 NETLGGTCLNVGCIPSKALLNNSHYYHMAHGKDFASRGIEMSEVRLNLDKMMEQKSTAVK
.. :::::.::::.:.:.. :.. . .. : : :. :. : ..: . :.... :.
NP_000 HK-LGGTCVNVGCVPKKVMWNTAVHSEFMH--DHADYGFPSCEGKFNWRVIKEKRDAYVS
100 110 120 130 140 150
140 150 160 170 180
pF1KB4 ALTGGIAHLFKQNKVVHVNGYGKITGKNQVTATKADGGTQVIDTKNILIATGS-EVTP--
:.. . . .... . :.. .:. . : ...: . . .::::::. ::
NP_000 RLNAIYQNNLTKSHIEIIRGHAAFTSDPKPTI-EVSG--KKYTAPHILIATGGMPSTPHE
160 170 180 190 200
190 200 210 220 230 240
pF1KB4 --FPGITIDEDTIVSSTGALSFKKVPEKMVVIGAGVIGVELGSVWQRLGADVTAVEFLGH
.:: .. ..: : ......: . :..::: :.::.... . ::. .. . .
NP_000 SQIPGASLG----ITSDGFFQLEELPGRSVIVGAGYIAVEMAGILSALGSKTSLMIRHDK
210 220 230 240 250 260
250 260 270 280 290 300
pF1KB4 VGGVGIDMEISKNFQRILQKQGFKFKLNTKVTGATKKSDGKIDVSIEAASGGKAEVIT--
: ..: :: : . :.. : . :. . . .::. . ..::. .: :. :.:
NP_000 VLR-SFDSMISTNCTEELENAGVEV-LKFSQVKEVKKTLSGLEVSMVTAVPGRLPVMTMI
270 280 290 300 310 320
310 320 330 340 350 360
pF1KB4 --CDVLLVCIGRRPFTKNLGLEELGIELDPRGRIPVNTRFQTKIPNIYAIGDVVAGPMLA
: :: ::: : ::.:.:..:::. : .:.: :. .:.. .:::.::: . .:.
NP_000 PDVDCLLWAIGRVPNTKDLSLNKLGIQTDDKGHIIVDEFQNTNVKGIYAVGDVCGKALLT
330 340 350 360 370 380
370 380 390 400 410
pF1KB4 HKAEDEGIICVEGM--AGGAVHIDYNCVPSVIYTHPEVAWVGKSE-EQLKEEGIE-YKVG
: : .. . ..::: .:.:...:: .. :: .: : ... ::: :.
NP_000 PVAIAAGRKLAHRLFEYKEDSKLDYNNIPTVVFSHPPIGTVGLTEDEAIHKYGIENVKTY
390 400 410 420 430 440
420 430 440 450 460 470
pF1KB4 KFPFAANSRAKTNADTDGMVKILGQKSTDRVLGAHILGPGAGEMVNEAALALEYGASCED
. :. .: :. : ..:.. .. ..:.: :. : : ::.. :.:...::. :
NP_000 STSFTPMYHAVTKRKTKCVMKMVCANKEEKVVGIHMQGLGCDEMLQGFAVAVKMGATKAD
450 460 470 480 490 500
480 490 500
pF1KB4 IARVCHAHPTLSEAFREANLAASFGKSINF
. . ::: ::
NP_000 FDNTVAIHPTSSEELVTLR
510 520
>>NP_001248375 (OMIM: 601112) thioredoxin reductase 1, c (461 aa)
initn: 515 init1: 133 opt: 601 Z-score: 744.8 bits: 147.2 E(85289): 9.6e-35
Smith-Waterman score: 628; 30.3% identity (63.5% similar) in 446 aa overlap (76-507:17-454)
50 60 70 80 90 100
pF1KB4 VIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGGTCLNVGCIPSKALLNNSHYYHMAHGKD
:::::.::::::.: :.... .: .:
NP_001 MVLDFVTPTPLGTRWGLGGTCVNVGCIPKK-LMHQAALLGQAL-QD
10 20 30 40
110 120 130 140 150 160
pF1KB4 FASRGIEMSE-VRLNLDKMMEQKSTAVKALTGGIAHLFKQNKVVHVNGYGKITGKNQVTA
. : .. : :. . :.:.: .. . .:. : ....:::. :.::.. : ... :
NP_001 SRNYGWKVEETVKHDWDRMIEAVQNHIGSLNWGYRVALREKKVVYENAYGQFIGPHRIKA
50 60 70 80 90 100
170 180 190 200 210 220
pF1KB4 TKADGGTQVIDTKNILIATGSEVTPFPGITIDEDTIVSSTGALSFKKVPEKMVVIGAGVI
:. : .. ... .::::: : . :: :.. .:: .:. : : .:.::. .
NP_001 TNNKGKEKIYSAERFLIATG-ERPRYLGIPGDKEYCISSDDLFSLPYCPGKTLVVGASYV
110 120 130 140 150 160
230 240 250 260 270 280
pF1KB4 GVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGFKFK---LNTKVTGA
..: .. .: :::.. . . :.:....... . ....:.:: . ::
NP_001 ALECAGFLAGIGLDVTVM--VRSILLRGFDQDMANKIGEHMEEHGIKFIRQFVPIKVEQI
170 180 190 200 210 220
290 300 310 320 330
pF1KB4 TKKSDGKIDVSIEAASGGKAEVITCD--VLLVCIGRRPFTKNLGLEELGIELDPR-GRIP
. :.. : : : .. :.: . .... ::: :...::: .:.... . :.::
NP_001 EAGTPGRLRVV--AQSTNSEEIIEGEYNTVMLAIGRDACTRKIGLETVGVKINEKTGKIP
230 240 250 260 270
340 350 360 370 380 390
pF1KB4 VNTRFQTKIPNIYAIGDVVAGPM-LAHKAEDEGIICVEGM-AGGAVHIDYNCVPSVIYTH
:. . ::..: ::::::.. . :. : . : . .. . ::..:. ::. ::....:
NP_001 VTDEEQTNVPYIYAIGDILEDKVELTPVAIQAGRLLAQRLYAGSTVKCDYENVPTTVFTP
280 290 300 310 320 330
400 410 420 430 440 450
pF1KB4 PEVAWVGKSEEQ----LKEEGIE-YKVGKFPFAANSRAKTNADTDGMVKILGQKSTDRVL
: . : :::. . ::.:: :. .:. . .. : . . : . :...::.
NP_001 LEYGACGLSEEKAVEKFGEENIEVYHSYFWPLEWTIPSRDNNKCYAKI-ICNTKDNERVV
340 350 360 370 380 390
460 470 480 490 500
pF1KB4 GAHILGPGAGEMVNEAALALEYGASCEDIARVCHAHPTLSEAFREANLAASFGKSINF
: :.:::.:::... : ::. : . ... . ::. .:.: ... : ::
NP_001 GFHVLGPNAGEVTQGFAAALKCGLTKKQLDSTIGIHPVCAEVFTTLSVTKRSGASILQAG
400 410 420 430 440 450
NP_001 CCG
460
>>NP_877393 (OMIM: 601112) thioredoxin reductase 1, cyto (499 aa)
initn: 574 init1: 133 opt: 601 Z-score: 744.3 bits: 147.2 E(85289): 1e-34
Smith-Waterman score: 687; 30.5% identity (62.2% similar) in 495 aa overlap (37-507:6-492)
10 20 30 40 50 60
pF1KB4 VYCSLAKRGHFNRISHGLQGLSAVPLRTYADQP--IDADVTVIGSGPGGYVAAIKAAQLG
: : : :. .::.: :: .:: .::: :
NP_877 MNGPEDLPKSYDYDLIIIGGGSGGLAAAKEAAQYG
10 20 30
70 80 90 100 110
pF1KB4 FKTVCIE--------KNETLGGTCLNVGCIPSKALLNNSHYYHMAHGKDFASRGIEMSE-
:.. .. :::::.::::::.: :.... .: .: . : .. :
NP_877 KKVMVLDFVTPTPLGTRWGLGGTCVNVGCIPKK-LMHQAALLGQAL-QDSRNYGWKVEET
40 50 60 70 80 90
120 130 140 150 160 170
pF1KB4 VRLNLDKMMEQKSTAVKALTGGIAHLFKQNKVVHVNGYGKITGKNQVTATKADGGTQVID
:. . :.:.: .. . .:. : ....:::. :.::.. : ... ::. : .. .
NP_877 VKHDWDRMIEAVQNHIGSLNWGYRVALREKKVVYENAYGQFIGPHRIKATNNKGKEKIYS
100 110 120 130 140 150
180 190 200 210 220 230
pF1KB4 TKNILIATGSEVTPFPGITIDEDTIVSSTGALSFKKVPEKMVVIGAGVIGVELGSVWQRL
.. .::::: : . :: :.. .:: .:. : : .:.::. ...: .. .
NP_877 AERFLIATG-ERPRYLGIPGDKEYCISSDDLFSLPYCPGKTLVVGASYVALECAGFLAGI
160 170 180 190 200 210
240 250 260 270 280 290
pF1KB4 GADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGFKFK---LNTKVTGATKKSDGKIDVS
: :::.. . . :.:....... . ....:.:: . :: . :.. :
NP_877 GLDVTVM--VRSILLRGFDQDMANKIGEHMEEHGIKFIRQFVPIKVEQIEAGTPGRLRVV
220 230 240 250 260 270
300 310 320 330 340
pF1KB4 IEAASGGKAEVITCD--VLLVCIGRRPFTKNLGLEELGIELDPR-GRIPVNTRFQTKIPN
: : .. :.: . .... ::: :...::: .:.... . :.:::. . ::..:
NP_877 --AQSTNSEEIIEGEYNTVMLAIGRDACTRKIGLETVGVKINEKTGKIPVTDEEQTNVPY
280 290 300 310 320
350 360 370 380 390 400
pF1KB4 IYAIGDVVAGPM-LAHKAEDEGIICVEGM-AGGAVHIDYNCVPSVIYTHPEVAWVGKSEE
::::::.. . :. : . : . .. . ::..:. ::. ::....: : . : :::
NP_877 IYAIGDILEDKVELTPVAIQAGRLLAQRLYAGSTVKCDYENVPTTVFTPLEYGACGLSEE
330 340 350 360 370 380
410 420 430 440 450 460
pF1KB4 Q----LKEEGIE-YKVGKFPFAANSRAKTNADTDGMVKILGQKSTDRVLGAHILGPGAGE
. . ::.:: :. .:. . .. : . . : . :...::.: :.:::.:::
NP_877 KAVEKFGEENIEVYHSYFWPLEWTIPSRDNNKCYAKI-ICNTKDNERVVGFHVLGPNAGE
390 400 410 420 430 440
470 480 490 500
pF1KB4 MVNEAALALEYGASCEDIARVCHAHPTLSEAFREANLAASFGKSINF
... : ::. : . ... . ::. .:.: ... : ::
NP_877 VTQGFAAALKCGLTKKQLDSTIGIHPVCAEVFTTLSVTKRSGASILQAGCCG
450 460 470 480 490
>>NP_877420 (OMIM: 601112) thioredoxin reductase 1, cyto (499 aa)
initn: 574 init1: 133 opt: 601 Z-score: 744.3 bits: 147.2 E(85289): 1e-34
Smith-Waterman score: 687; 30.5% identity (62.2% similar) in 495 aa overlap (37-507:6-492)
10 20 30 40 50 60
pF1KB4 VYCSLAKRGHFNRISHGLQGLSAVPLRTYADQP--IDADVTVIGSGPGGYVAAIKAAQLG
: : : :. .::.: :: .:: .::: :
NP_877 MNGPEDLPKSYDYDLIIIGGGSGGLAAAKEAAQYG
10 20 30
70 80 90 100 110
pF1KB4 FKTVCIE--------KNETLGGTCLNVGCIPSKALLNNSHYYHMAHGKDFASRGIEMSE-
:.. .. :::::.::::::.: :.... .: .: . : .. :
NP_877 KKVMVLDFVTPTPLGTRWGLGGTCVNVGCIPKK-LMHQAALLGQAL-QDSRNYGWKVEET
40 50 60 70 80 90
120 130 140 150 160 170
pF1KB4 VRLNLDKMMEQKSTAVKALTGGIAHLFKQNKVVHVNGYGKITGKNQVTATKADGGTQVID
:. . :.:.: .. . .:. : ....:::. :.::.. : ... ::. : .. .
NP_877 VKHDWDRMIEAVQNHIGSLNWGYRVALREKKVVYENAYGQFIGPHRIKATNNKGKEKIYS
100 110 120 130 140 150
180 190 200 210 220 230
pF1KB4 TKNILIATGSEVTPFPGITIDEDTIVSSTGALSFKKVPEKMVVIGAGVIGVELGSVWQRL
.. .::::: : . :: :.. .:: .:. : : .:.::. ...: .. .
NP_877 AERFLIATG-ERPRYLGIPGDKEYCISSDDLFSLPYCPGKTLVVGASYVALECAGFLAGI
160 170 180 190 200 210
240 250 260 270 280 290
pF1KB4 GADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGFKFK---LNTKVTGATKKSDGKIDVS
: :::.. . . :.:....... . ....:.:: . :: . :.. :
NP_877 GLDVTVM--VRSILLRGFDQDMANKIGEHMEEHGIKFIRQFVPIKVEQIEAGTPGRLRVV
220 230 240 250 260 270
300 310 320 330 340
pF1KB4 IEAASGGKAEVITCD--VLLVCIGRRPFTKNLGLEELGIELDPR-GRIPVNTRFQTKIPN
: : .. :.: . .... ::: :...::: .:.... . :.:::. . ::..:
NP_877 --AQSTNSEEIIEGEYNTVMLAIGRDACTRKIGLETVGVKINEKTGKIPVTDEEQTNVPY
280 290 300 310 320
350 360 370 380 390 400
pF1KB4 IYAIGDVVAGPM-LAHKAEDEGIICVEGM-AGGAVHIDYNCVPSVIYTHPEVAWVGKSEE
::::::.. . :. : . : . .. . ::..:. ::. ::....: : . : :::
NP_877 IYAIGDILEDKVELTPVAIQAGRLLAQRLYAGSTVKCDYENVPTTVFTPLEYGACGLSEE
330 340 350 360 370 380
410 420 430 440 450 460
pF1KB4 Q----LKEEGIE-YKVGKFPFAANSRAKTNADTDGMVKILGQKSTDRVLGAHILGPGAGE
. . ::.:: :. .:. . .. : . . : . :...::.: :.:::.:::
NP_877 KAVEKFGEENIEVYHSYFWPLEWTIPSRDNNKCYAKI-ICNTKDNERVVGFHVLGPNAGE
390 400 410 420 430 440
470 480 490 500
pF1KB4 MVNEAALALEYGASCEDIARVCHAHPTLSEAFREANLAASFGKSINF
... : ::. : . ... . ::. .:.: ... : ::
NP_877 VTQGFAAALKCGLTKKQLDSTIGIHPVCAEVFTTLSVTKRSGASILQAGCCG
450 460 470 480 490
>>NP_877419 (OMIM: 601112) thioredoxin reductase 1, cyto (499 aa)
initn: 574 init1: 133 opt: 601 Z-score: 744.3 bits: 147.2 E(85289): 1e-34
Smith-Waterman score: 687; 30.5% identity (62.2% similar) in 495 aa overlap (37-507:6-492)
10 20 30 40 50 60
pF1KB4 VYCSLAKRGHFNRISHGLQGLSAVPLRTYADQP--IDADVTVIGSGPGGYVAAIKAAQLG
: : : :. .::.: :: .:: .::: :
NP_877 MNGPEDLPKSYDYDLIIIGGGSGGLAAAKEAAQYG
10 20 30
70 80 90 100 110
pF1KB4 FKTVCIE--------KNETLGGTCLNVGCIPSKALLNNSHYYHMAHGKDFASRGIEMSE-
:.. .. :::::.::::::.: :.... .: .: . : .. :
NP_877 KKVMVLDFVTPTPLGTRWGLGGTCVNVGCIPKK-LMHQAALLGQAL-QDSRNYGWKVEET
40 50 60 70 80 90
120 130 140 150 160 170
pF1KB4 VRLNLDKMMEQKSTAVKALTGGIAHLFKQNKVVHVNGYGKITGKNQVTATKADGGTQVID
:. . :.:.: .. . .:. : ....:::. :.::.. : ... ::. : .. .
NP_877 VKHDWDRMIEAVQNHIGSLNWGYRVALREKKVVYENAYGQFIGPHRIKATNNKGKEKIYS
100 110 120 130 140 150
180 190 200 210 220 230
pF1KB4 TKNILIATGSEVTPFPGITIDEDTIVSSTGALSFKKVPEKMVVIGAGVIGVELGSVWQRL
.. .::::: : . :: :.. .:: .:. : : .:.::. ...: .. .
NP_877 AERFLIATG-ERPRYLGIPGDKEYCISSDDLFSLPYCPGKTLVVGASYVALECAGFLAGI
160 170 180 190 200 210
240 250 260 270 280 290
pF1KB4 GADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGFKFK---LNTKVTGATKKSDGKIDVS
: :::.. . . :.:....... . ....:.:: . :: . :.. :
NP_877 GLDVTVM--VRSILLRGFDQDMANKIGEHMEEHGIKFIRQFVPIKVEQIEAGTPGRLRVV
220 230 240 250 260 270
300 310 320 330 340
pF1KB4 IEAASGGKAEVITCD--VLLVCIGRRPFTKNLGLEELGIELDPR-GRIPVNTRFQTKIPN
: : .. :.: . .... ::: :...::: .:.... . :.:::. . ::..:
NP_877 --AQSTNSEEIIEGEYNTVMLAIGRDACTRKIGLETVGVKINEKTGKIPVTDEEQTNVPY
280 290 300 310 320
350 360 370 380 390 400
pF1KB4 IYAIGDVVAGPM-LAHKAEDEGIICVEGM-AGGAVHIDYNCVPSVIYTHPEVAWVGKSEE
::::::.. . :. : . : . .. . ::..:. ::. ::....: : . : :::
NP_877 IYAIGDILEDKVELTPVAIQAGRLLAQRLYAGSTVKCDYENVPTTVFTPLEYGACGLSEE
330 340 350 360 370 380
410 420 430 440 450 460
pF1KB4 Q----LKEEGIE-YKVGKFPFAANSRAKTNADTDGMVKILGQKSTDRVLGAHILGPGAGE
. . ::.:: :. .:. . .. : . . : . :...::.: :.:::.:::
NP_877 KAVEKFGEENIEVYHSYFWPLEWTIPSRDNNKCYAKI-ICNTKDNERVVGFHVLGPNAGE
390 400 410 420 430 440
470 480 490 500
pF1KB4 MVNEAALALEYGASCEDIARVCHAHPTLSEAFREANLAASFGKSINF
... : ::. : . ... . ::. .:.: ... : ::
NP_877 VTQGFAAALKCGLTKKQLDSTIGIHPVCAEVFTTLSVTKRSGASILQAGCCG
450 460 470 480 490
>>NP_001248374 (OMIM: 601112) thioredoxin reductase 1, c (549 aa)
initn: 592 init1: 133 opt: 601 Z-score: 743.6 bits: 147.3 E(85289): 1.1e-34
Smith-Waterman score: 687; 30.5% identity (62.2% similar) in 495 aa overlap (37-507:56-542)
10 20 30 40 50 60
pF1KB4 VYCSLAKRGHFNRISHGLQGLSAVPLRTYADQP--IDADVTVIGSGPGGYVAAIKAAQLG
: : : :. .::.: :: .:: .::: :
NP_001 KQRKIGGHGPTLKAYQEGRLQKLLKMNGPEDLPKSYDYDLIIIGGGSGGLAAAKEAAQYG
30 40 50 60 70 80
70 80 90 100 110
pF1KB4 FKTVCIE--------KNETLGGTCLNVGCIPSKALLNNSHYYHMAHGKDFASRGIEMSE-
:.. .. :::::.::::::.: :.... .: .: . : .. :
NP_001 KKVMVLDFVTPTPLGTRWGLGGTCVNVGCIPKK-LMHQAALLGQAL-QDSRNYGWKVEET
90 100 110 120 130 140
120 130 140 150 160 170
pF1KB4 VRLNLDKMMEQKSTAVKALTGGIAHLFKQNKVVHVNGYGKITGKNQVTATKADGGTQVID
:. . :.:.: .. . .:. : ....:::. :.::.. : ... ::. : .. .
NP_001 VKHDWDRMIEAVQNHIGSLNWGYRVALREKKVVYENAYGQFIGPHRIKATNNKGKEKIYS
150 160 170 180 190 200
180 190 200 210 220 230
pF1KB4 TKNILIATGSEVTPFPGITIDEDTIVSSTGALSFKKVPEKMVVIGAGVIGVELGSVWQRL
.. .::::: : . :: :.. .:: .:. : : .:.::. ...: .. .
NP_001 AERFLIATG-ERPRYLGIPGDKEYCISSDDLFSLPYCPGKTLVVGASYVALECAGFLAGI
210 220 230 240 250 260
240 250 260 270 280 290
pF1KB4 GADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGFKFK---LNTKVTGATKKSDGKIDVS
: :::.. . . :.:....... . ....:.:: . :: . :.. :
NP_001 GLDVTVM--VRSILLRGFDQDMANKIGEHMEEHGIKFIRQFVPIKVEQIEAGTPGRLRVV
270 280 290 300 310 320
300 310 320 330 340
pF1KB4 IEAASGGKAEVITCD--VLLVCIGRRPFTKNLGLEELGIELDPR-GRIPVNTRFQTKIPN
: : .. :.: . .... ::: :...::: .:.... . :.:::. . ::..:
NP_001 --AQSTNSEEIIEGEYNTVMLAIGRDACTRKIGLETVGVKINEKTGKIPVTDEEQTNVPY
330 340 350 360 370
350 360 370 380 390 400
pF1KB4 IYAIGDVVAGPM-LAHKAEDEGIICVEGM-AGGAVHIDYNCVPSVIYTHPEVAWVGKSEE
::::::.. . :. : . : . .. . ::..:. ::. ::....: : . : :::
NP_001 IYAIGDILEDKVELTPVAIQAGRLLAQRLYAGSTVKCDYENVPTTVFTPLEYGACGLSEE
380 390 400 410 420 430
410 420 430 440 450 460
pF1KB4 Q----LKEEGIE-YKVGKFPFAANSRAKTNADTDGMVKILGQKSTDRVLGAHILGPGAGE
. . ::.:: :. .:. . .. : . . : . :...::.: :.:::.:::
NP_001 KAVEKFGEENIEVYHSYFWPLEWTIPSRDNNKCYAKI-ICNTKDNERVVGFHVLGPNAGE
440 450 460 470 480 490
470 480 490 500
pF1KB4 MVNEAALALEYGASCEDIARVCHAHPTLSEAFREANLAASFGKSINF
... : ::. : . ... . ::. .:.: ... : ::
NP_001 VTQGFAAALKCGLTKKQLDSTIGIHPVCAEVFTTLSVTKRSGASILQAGCCG
500 510 520 530 540
509 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sat Nov 5 06:10:03 2016 done: Sat Nov 5 06:10:04 2016
Total Scan time: 8.680 Total Display time: 0.070
Function used was FASTA [36.3.4 Apr, 2011]