Result of FASTA (omim) for
pFN21AE0915
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE0915, 263 aa
1>>>pF1KE0915 263 - 263 aa - 263 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.5099+/-0.000349; mu= 13.5579+/- 0.022
mean_var=63.4742+/-12.812, 0's: 0 Z-trim(113.6): 34 B-trim: 31 in 1/48
Lambda= 0.160981
statistics sampled from 22976 (23007) to 22976 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.647), E-opt: 0.2 (0.27), width: 16
Scan time: 5.440
The best scores are: opt bits E(85289)
NP_002788 (OMIM: 600306) proteasome subunit beta t ( 263) 1750 415.0 7.2e-116
XP_005267928 (OMIM: 600306) PREDICTED: proteasome ( 169) 1130 270.9 1.1e-72
NP_001138404 (OMIM: 600306) proteasome subunit bet ( 203) 1122 269.1 4.6e-72
NP_001124197 (OMIM: 600306) proteasome subunit bet ( 160) 1078 258.8 4.4e-69
NP_683720 (OMIM: 177046,256040) proteasome subunit ( 276) 1010 243.1 4.1e-64
NP_004150 (OMIM: 177046,256040) proteasome subunit ( 272) 1009 242.9 4.7e-64
NP_001093250 (OMIM: 611137) proteasome subunit bet ( 300) 771 187.6 2.3e-47
NP_002789 (OMIM: 600307) proteasome subunit beta t ( 239) 343 88.2 1.5e-17
NP_002791 (OMIM: 177045) proteasome subunit beta t ( 219) 313 81.2 1.8e-15
NP_001257410 (OMIM: 600307) proteasome subunit bet ( 213) 293 76.5 4.4e-14
NP_002790 (OMIM: 604030) proteasome subunit beta t ( 277) 294 76.8 4.7e-14
NP_002792 (OMIM: 176847) proteasome subunit beta t ( 273) 280 73.6 4.4e-13
NP_002787 (OMIM: 602177) proteasome subunit beta t ( 264) 187 52.0 1.4e-06
NP_002786 (OMIM: 602176) proteasome subunit beta t ( 205) 184 51.2 1.8e-06
NP_002778 (OMIM: 176842) proteasome subunit alpha ( 234) 175 49.1 8.4e-06
NP_002785 (OMIM: 602175) proteasome subunit beta t ( 201) 162 46.1 6e-05
NP_002783 (OMIM: 606607) proteasome subunit alpha ( 248) 157 45.0 0.00016
NP_002784 (OMIM: 602017) proteasome subunit beta t ( 241) 154 44.3 0.00025
NP_001186708 (OMIM: 602175) proteasome subunit bet ( 176) 146 42.4 0.0007
NP_001096137 (OMIM: 176846) proteasome subunit alp ( 261) 136 40.1 0.0049
NP_002780 (OMIM: 176846) proteasome subunit alpha ( 261) 136 40.1 0.0049
NP_001317605 (OMIM: 176846) proteasome subunit alp ( 261) 136 40.1 0.0049
>>NP_002788 (OMIM: 600306) proteasome subunit beta type- (263 aa)
initn: 1750 init1: 1750 opt: 1750 Z-score: 2201.2 bits: 415.0 E(85289): 7.2e-116
Smith-Waterman score: 1750; 100.0% identity (100.0% similar) in 263 aa overlap (1-263:1-263)
10 20 30 40 50 60
pF1KE0 MALASVLERPLPVNQRGFFGLGGRADLLDLGPGSLSDGLSLAAPGWGVPEEPGIEMLHGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 MALASVLERPLPVNQRGFFGLGGRADLLDLGPGSLSDGLSLAAPGWGVPEEPGIEMLHGT
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 TTLAFKFRHGVIVAADSRATAGAYIASQTVKKVIEINPYLLGTMAGGAADCSFWERLLAR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 TTLAFKFRHGVIVAADSRATAGAYIASQTVKKVIEINPYLLGTMAGGAADCSFWERLLAR
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE0 QCRIYELRNKERISVAAASKLLANMVYQYKGMGLSMGTMICGWDKRGPGLYYVDSEGNRI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 QCRIYELRNKERISVAAASKLLANMVYQYKGMGLSMGTMICGWDKRGPGLYYVDSEGNRI
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE0 SGATFSVGSGSVYAYGVMDRGYSYDLEVEQAYDLARRAIYQATYRDAYSGGAVNLYHVRE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 SGATFSVGSGSVYAYGVMDRGYSYDLEVEQAYDLARRAIYQATYRDAYSGGAVNLYHVRE
190 200 210 220 230 240
250 260
pF1KE0 DGWIRVSSDNVADLHEKYSGSTP
:::::::::::::::::::::::
NP_002 DGWIRVSSDNVADLHEKYSGSTP
250 260
>>XP_005267928 (OMIM: 600306) PREDICTED: proteasome subu (169 aa)
initn: 1130 init1: 1130 opt: 1130 Z-score: 1426.1 bits: 270.9 E(85289): 1.1e-72
Smith-Waterman score: 1130; 100.0% identity (100.0% similar) in 169 aa overlap (1-169:1-169)
10 20 30 40 50 60
pF1KE0 MALASVLERPLPVNQRGFFGLGGRADLLDLGPGSLSDGLSLAAPGWGVPEEPGIEMLHGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MALASVLERPLPVNQRGFFGLGGRADLLDLGPGSLSDGLSLAAPGWGVPEEPGIEMLHGT
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 TTLAFKFRHGVIVAADSRATAGAYIASQTVKKVIEINPYLLGTMAGGAADCSFWERLLAR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TTLAFKFRHGVIVAADSRATAGAYIASQTVKKVIEINPYLLGTMAGGAADCSFWERLLAR
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE0 QCRIYELRNKERISVAAASKLLANMVYQYKGMGLSMGTMICGWDKRGPGLYYVDSEGNRI
:::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QCRIYELRNKERISVAAASKLLANMVYQYKGMGLSMGTMICGWDKRGPG
130 140 150 160
190 200 210 220 230 240
pF1KE0 SGATFSVGSGSVYAYGVMDRGYSYDLEVEQAYDLARRAIYQATYRDAYSGGAVNLYHVRE
>>NP_001138404 (OMIM: 600306) proteasome subunit beta ty (203 aa)
initn: 1122 init1: 1122 opt: 1122 Z-score: 1414.7 bits: 269.1 E(85289): 4.6e-72
Smith-Waterman score: 1122; 100.0% identity (100.0% similar) in 168 aa overlap (1-168:1-168)
10 20 30 40 50 60
pF1KE0 MALASVLERPLPVNQRGFFGLGGRADLLDLGPGSLSDGLSLAAPGWGVPEEPGIEMLHGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MALASVLERPLPVNQRGFFGLGGRADLLDLGPGSLSDGLSLAAPGWGVPEEPGIEMLHGT
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 TTLAFKFRHGVIVAADSRATAGAYIASQTVKKVIEINPYLLGTMAGGAADCSFWERLLAR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TTLAFKFRHGVIVAADSRATAGAYIASQTVKKVIEINPYLLGTMAGGAADCSFWERLLAR
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE0 QCRIYELRNKERISVAAASKLLANMVYQYKGMGLSMGTMICGWDKRGPGLYYVDSEGNRI
::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QCRIYELRNKERISVAAASKLLANMVYQYKGMGLSMGTMICGWDKRGPVSEVLCLKPKSF
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE0 SGATFSVGSGSVYAYGVMDRGYSYDLEVEQAYDLARRAIYQATYRDAYSGGAVNLYHVRE
NP_001 GMYLFCGCAERIGNMARPLLRGQ
190 200
>>NP_001124197 (OMIM: 600306) proteasome subunit beta ty (160 aa)
initn: 1078 init1: 1078 opt: 1078 Z-score: 1361.2 bits: 258.8 E(85289): 4.4e-69
Smith-Waterman score: 1078; 100.0% identity (100.0% similar) in 160 aa overlap (104-263:1-160)
80 90 100 110 120 130
pF1KE0 AADSRATAGAYIASQTVKKVIEINPYLLGTMAGGAADCSFWERLLARQCRIYELRNKERI
::::::::::::::::::::::::::::::
NP_001 MAGGAADCSFWERLLARQCRIYELRNKERI
10 20 30
140 150 160 170 180 190
pF1KE0 SVAAASKLLANMVYQYKGMGLSMGTMICGWDKRGPGLYYVDSEGNRISGATFSVGSGSVY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SVAAASKLLANMVYQYKGMGLSMGTMICGWDKRGPGLYYVDSEGNRISGATFSVGSGSVY
40 50 60 70 80 90
200 210 220 230 240 250
pF1KE0 AYGVMDRGYSYDLEVEQAYDLARRAIYQATYRDAYSGGAVNLYHVREDGWIRVSSDNVAD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AYGVMDRGYSYDLEVEQAYDLARRAIYQATYRDAYSGGAVNLYHVREDGWIRVSSDNVAD
100 110 120 130 140 150
260
pF1KE0 LHEKYSGSTP
::::::::::
NP_001 LHEKYSGSTP
160
>>NP_683720 (OMIM: 177046,256040) proteasome subunit bet (276 aa)
initn: 1028 init1: 1009 opt: 1010 Z-score: 1272.0 bits: 243.1 E(85289): 4.1e-64
Smith-Waterman score: 1010; 62.0% identity (83.9% similar) in 242 aa overlap (17-258:31-271)
10 20 30 40
pF1KE0 MALASVLERPLPVNQRGFFGLGGRADLLDLGPGSLSDGLSLAAPGW
: .... :. : : : ... . . :
NP_683 MALLDVCGAPRGQRPESALPVAGSGRRSDPGHYSFSMRSPELAL-PRGMQPTEFFQSLGG
10 20 30 40 50
50 60 70 80 90 100
pF1KE0 GVPEEPGIEMLHGTTTLAFKFRHGVIVAADSRATAGAYIASQTVKKVIEINPYLLGTMAG
.. ::: ::::::::::.::::.:.::::.::.::.. :.:::::::::::::.:
NP_683 DGERNVQIEMAHGTTTLAFKFQHGVIAAVDSRASAGSYISALRVNKVIEINPYLLGTMSG
60 70 80 90 100 110
110 120 130 140 150 160
pF1KE0 GAADCSFWERLLARQCRIYELRNKERISVAAASKLLANMVYQYKGMGLSMGTMICGWDKR
::::..::::::..::.: ::: :::::.::::::.::. ::.:::::::.:::::::.
NP_683 CAADCQYWERLLAKECRLYYLRNGERISVSAASKLLSNMMCQYRGMGLSMGSMICGWDKK
120 130 140 150 160 170
170 180 190 200 210 220
pF1KE0 GPGLYYVDSEGNRISGATFSVGSGSVYAYGVMDRGYSYDLEVEQAYDLARRAIYQATYRD
:::::::: .:.:.:: ::.:::..::::::: :: .: :.::::.:::: ::.::
NP_683 GPGLYYVDEHGTRLSGNMFSTGSGNTYAYGVMDSGYRPNLSPEEAYDLGRRAIAYATHRD
180 190 200 210 220 230
230 240 250 260
pF1KE0 AYSGGAVNLYHVREDGWIRVSSDNVADLHEKYSGSTP
.::::.::.::..::::..: : .:.:: ..:
NP_683 SYSGGVVNMYHMKEDGWVKVESTDVSDLLHQYREANQ
240 250 260 270
>>NP_004150 (OMIM: 177046,256040) proteasome subunit bet (272 aa)
initn: 1028 init1: 1009 opt: 1009 Z-score: 1270.9 bits: 242.9 E(85289): 4.7e-64
Smith-Waterman score: 1009; 70.2% identity (90.2% similar) in 205 aa overlap (54-258:63-267)
30 40 50 60 70 80
pF1KE0 RADLLDLGPGSLSDGLSLAAPGWGVPEEPGIEMLHGTTTLAFKFRHGVIVAADSRATAGA
::: ::::::::::.::::.:.::::.::.
NP_004 LPTPVSSGCPGLEPTEFFQSLGGDGERNVQIEMAHGTTTLAFKFQHGVIAAVDSRASAGS
40 50 60 70 80 90
90 100 110 120 130 140
pF1KE0 YIASQTVKKVIEINPYLLGTMAGGAADCSFWERLLARQCRIYELRNKERISVAAASKLLA
::.. :.:::::::::::::.: ::::..::::::..::.: ::: :::::.::::::.
NP_004 YISALRVNKVIEINPYLLGTMSGCAADCQYWERLLAKECRLYYLRNGERISVSAASKLLS
100 110 120 130 140 150
150 160 170 180 190 200
pF1KE0 NMVYQYKGMGLSMGTMICGWDKRGPGLYYVDSEGNRISGATFSVGSGSVYAYGVMDRGYS
::. ::.:::::::.:::::::.:::::::: .:.:.:: ::.:::..::::::: ::
NP_004 NMMCQYRGMGLSMGSMICGWDKKGPGLYYVDEHGTRLSGNMFSTGSGNTYAYGVMDSGYR
160 170 180 190 200 210
210 220 230 240 250 260
pF1KE0 YDLEVEQAYDLARRAIYQATYRDAYSGGAVNLYHVREDGWIRVSSDNVADLHEKYSGSTP
.: :.::::.:::: ::.::.::::.::.::..::::..: : .:.:: ..:
NP_004 PNLSPEEAYDLGRRAIAYATHRDSYSGGVVNMYHMKEDGWVKVESTDVSDLLHQYREANQ
220 230 240 250 260 270
>>NP_001093250 (OMIM: 611137) proteasome subunit beta ty (300 aa)
initn: 790 init1: 763 opt: 771 Z-score: 971.5 bits: 187.6 E(85289): 2.3e-47
Smith-Waterman score: 786; 52.7% identity (77.9% similar) in 222 aa overlap (43-255:24-245)
20 30 40 50 60
pF1KE0 VNQRGFFGLGGRADLLDLGPGSLSDGLSLAAPGWGVPE--EP-------GIEMLHGTTTL
: ::.::. .: : .. ::::::
NP_001 MALQDVCKWQSPDTQGPSPHLPRAGGWAVPRGCDPQTFLQIHGPRLAHGTTTL
10 20 30 40 50
70 80 90 100 110 120
pF1KE0 AFKFRHGVIVAADSRATAGAYIASQTVKKVIEINPYLLGTMAGGAADCSFWERLLARQCR
::.::::::.:::.:.. :.:.: . ::: .. .:::: .: .:::. : :.: :. :
NP_001 AFRFRHGVIAAADTRSSCGSYVACPASCKVIPVHQHLLGTTSGTSADCATWYRVLQRELR
60 70 80 90 100 110
130 140 150 160 170 180
pF1KE0 IYELRNKERISVAAASKLLANMVYQYKGMGLSMGTMICGWDKRGPGLYYVDSEGNRISGA
. :::. . :::.:.:::. :. ::.:. : ..: .::::. :: :.:: :.:.:..:
NP_001 LRELREGQLPSVASAAKLLSAMMSQYRGLDLCVATALCGWDRSGPELFYVYSDGTRLQGD
120 130 140 150 160 170
190 200 210 220 230 240
pF1KE0 TFSVGSGSVYAYGVMDRGYSYDLEVEQAYDLARRAIYQATYRDAYSGGAVNLYHVREDGW
::::::: :::::.:::: ::. ...:: ::: :. .::.:::::::.:.:.::::.::
NP_001 IFSVGSGSPYAYGVLDRGYRYDMSTQEAYALARCAVAHATHRDAYSGGSVDLFHVRESGW
180 190 200 210 220 230
250 260
pF1KE0 IRVSSDNVADLHEKYSGSTP
.:: ... :.
NP_001 EHVSRSDACVLYVELQKLLEPEPEEDASHAHPEPATAHRAAEDRELSVGPGEVTPGDSRM
240 250 260 270 280 290
>>NP_002789 (OMIM: 600307) proteasome subunit beta type- (239 aa)
initn: 318 init1: 262 opt: 343 Z-score: 435.8 bits: 88.2 E(85289): 1.5e-17
Smith-Waterman score: 343; 32.2% identity (60.0% similar) in 205 aa overlap (43-242:14-217)
20 30 40 50 60
pF1KE0 VNQRGFFGLGGRADLLDLGPGSLSDGLSLAAPGWG----VPEEPGIEMLHGTTTLAFKFR
::.:: .:. . :. ::: .: .:
NP_002 MAATLLAARGAGPAPAWGPEAFTPDWESREVSTGTTIMAVQFD
10 20 30 40
70 80 90 100 110 120
pF1KE0 HGVIVAADSRATAGAYIASQTVKKVIEINPYLLGTMAGGAADCSFWERLLARQCRIYELR
::...::::.:.:.:::.... :. :. .. .:.::: . .. : .. ..
NP_002 GGVVLGADSRTTTGSYIANRVTDKLTPIHDRIFCCRSGSAADTQAVADAVTYQLGFHSIE
50 60 70 80 90 100
130 140 150 160 170 180
pF1KE0 NKERISVAAASKLLANMVYQYKGMGLSMGTMICGWDKRGPGLYYVDSEGNRISGATFSVG
.: : .:..:. .: :.:. : : .: ::: . : : :. . .:..:
NP_002 LNEPPLVHTAASLFKEMCYRYR-EDLMAGIIIAGWDPQEGGQVYSVPMGGMMVRQSFAIG
110 120 130 140 150 160
190 200 210 220 230 240
pF1KE0 -SGSVYAYGVMDRGYSYDLEVEQAYDLARRAIYQATYRDAYSGGAVNLYHVREDGWIRVS
::: : :: .: : . :. ... :. : ::. :::.. : . :.:
NP_002 GSGSSYIYGYVDATYREGMTKEECLQFTANALALAMERDGSSGGVIRLAAIAESGVERQV
170 180 190 200 210 220
250 260
pF1KE0 SDNVADLHEKYSGSTP
NP_002 LLGDQIPKFAVATLPPA
230
>>NP_002791 (OMIM: 177045) proteasome subunit beta type- (219 aa)
initn: 326 init1: 155 opt: 313 Z-score: 398.8 bits: 81.2 E(85289): 1.8e-15
Smith-Waterman score: 313; 30.2% identity (60.0% similar) in 205 aa overlap (39-242:2-202)
10 20 30 40 50 60
pF1KE0 RPLPVNQRGFFGLGGRADLLDLGPGSLSDGLSLAAPGWGVPEEPGIEMLHGTTTLAFKFR
: .:: .:. : :. ::: .: .:
NP_002 MLRAGAPTGDLPRA-G-EVHTGTTIMAVEFD
10 20
70 80 90 100 110 120
pF1KE0 HGVIVAADSRATAGAYIASQTVKKVIEINPYLLGTMAGGAADCSFWERLLARQCRIYELR
::....:::..:: ..... :. .. . ...:.::: . . : : ... ..
NP_002 GGVVMGSDSRVSAGEAVVNRVFDKLSPLHERIYCALSGSAADAQAVADMAAYQLELHGIE
30 40 50 60 70 80
130 140 150 160 170 180
pF1KE0 NKERISVAAASKLLANMVYQYKGMGLSMGTMICGWDKRGPGLYYVDSEGNRISGATFSVG
.: : ::.... :. :.:. :: :. :::.: : : . :. .. :..:
NP_002 LEEPPLVLAAANVVRNISYKYR-EDLSAHLMVAGWDQREGGQVY-GTLGGMLTRQPFAIG
90 100 110 120 130 140
190 200 210 220 230 240
pF1KE0 -SGSVYAYGVMDRGYSYDLEVEQAYDLARRAIYQATYRDAYSGGAVNLYHVREDGWIRVS
:::.. :: .: .:. . :. .. :: : ::. :::.. : . :
NP_002 GSGSTFIYGYVDAAYKPGMSPEECRRFTTDAIALAMSRDGSSGGVIYLVTITAAGVDHRV
150 160 170 180 190 200
250 260
pF1KE0 SDNVADLHEKYSGSTP
NP_002 ILGNELPKFYDE
210
>>NP_001257410 (OMIM: 600307) proteasome subunit beta ty (213 aa)
initn: 260 init1: 204 opt: 293 Z-score: 373.9 bits: 76.5 E(85289): 4.4e-14
Smith-Waterman score: 293; 31.1% identity (60.1% similar) in 183 aa overlap (43-220:14-195)
20 30 40 50 60
pF1KE0 VNQRGFFGLGGRADLLDLGPGSLSDGLSLAAPGWG----VPEEPGIEMLHGTTTLAFKFR
::.:: .:. . :. ::: .: .:
NP_001 MAATLLAARGAGPAPAWGPEAFTPDWESREVSTGTTIMAVQFD
10 20 30 40
70 80 90 100 110 120
pF1KE0 HGVIVAADSRATAGAYIASQTVKKVIEINPYLLGTMAGGAADCSFWERLLARQCRIYELR
::...::::.:.:.:::.... :. :. .. .:.::: . .. : .. ..
NP_001 GGVVLGADSRTTTGSYIANRVTDKLTPIHDRIFCCRSGSAADTQAVADAVTYQLGFHSIE
50 60 70 80 90 100
130 140 150 160 170 180
pF1KE0 NKERISVAAASKLLANMVYQYKGMGLSMGTMICGWDKRGPGLYYVDSEGNRISGATFSVG
.: : .:..:. .: :.:. : : .: ::: . : : :. . .:..:
NP_001 LNEPPLVHTAASLFKEMCYRYR-EDLMAGIIIAGWDPQEGGQVYSVPMGGMMVRQSFAIG
110 120 130 140 150 160
190 200 210 220 230 240
pF1KE0 -SGSVYAYGVMDRGYSYDLEVEQAYDLARRAIYQATYRDAYSGGAVNLYHVREDGWIRVS
::: : :: .: : . :. ... :..
NP_001 GSGSSYIYGYVDATYREGMTKEECLQFTANAFFFYPQLSLWPWSGMAPVEE
170 180 190 200 210
250 260
pF1KE0 SDNVADLHEKYSGSTP
263 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sat Nov 5 04:29:02 2016 done: Sat Nov 5 04:29:03 2016
Total Scan time: 5.440 Total Display time: -0.030
Function used was FASTA [36.3.4 Apr, 2011]