Result of FASTA (omim) for
pFN21AE0665
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE0665, 240 aa
1>>>pF1KE0665 240 - 240 aa - 240 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 6.4875+/-0.000388; mu= 11.3487+/- 0.024
mean_var=193.3228+/-38.335, 0's: 0 Z-trim(119.0): 29 B-trim: 0 in 0/53
Lambda= 0.092243
statistics sampled from 32576 (32605) to 32576 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.726), E-opt: 0.2 (0.382), width: 16
Scan time: 6.120
The best scores are: opt bits E(85289)
NP_006749 (OMIM: 191317) splicing factor U2AF 35 k ( 240) 1677 235.0 9.1e-62
NP_001020374 (OMIM: 191317) splicing factor U2AF 3 ( 240) 1638 229.8 3.3e-60
NP_001020375 (OMIM: 191317) splicing factor U2AF 3 ( 167) 1180 168.6 6e-42
XP_016883957 (OMIM: 191317) PREDICTED: splicing fa ( 207) 889 130.0 3.1e-30
XP_011528045 (OMIM: 191317) PREDICTED: splicing fa ( 207) 889 130.0 3.1e-30
NP_001035515 (OMIM: 601080) splicing factor U2AF 2 ( 181) 680 102.1 6.7e-22
XP_005274654 (OMIM: 300028) PREDICTED: U2 small nu ( 348) 444 71.1 2.8e-12
XP_011543892 (OMIM: 300028) PREDICTED: U2 small nu ( 348) 444 71.1 2.8e-12
XP_016885372 (OMIM: 300028) PREDICTED: U2 small nu ( 348) 444 71.1 2.8e-12
XP_016885371 (OMIM: 300028) PREDICTED: U2 small nu ( 348) 444 71.1 2.8e-12
XP_011543891 (OMIM: 300028) PREDICTED: U2 small nu ( 460) 444 71.3 3.3e-12
NP_005080 (OMIM: 300028) U2 small nuclear ribonucl ( 482) 444 71.3 3.4e-12
XP_016885370 (OMIM: 300028) PREDICTED: U2 small nu ( 486) 444 71.3 3.5e-12
NP_659424 (OMIM: 601080) splicing factor U2AF 26 k ( 202) 369 60.8 2.1e-09
>>NP_006749 (OMIM: 191317) splicing factor U2AF 35 kDa s (240 aa)
initn: 1677 init1: 1677 opt: 1677 Z-score: 1229.9 bits: 235.0 E(85289): 9.1e-62
Smith-Waterman score: 1677; 100.0% identity (100.0% similar) in 240 aa overlap (1-240:1-240)
10 20 30 40 50 60
pF1KE0 MAEYLASIFGTEKDKVNCSFYFKIGACRHGDRCSRLHNKPTFSQTIALLNIYRNPQNSSQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 MAEYLASIFGTEKDKVNCSFYFKIGACRHGDRCSRLHNKPTFSQTIALLNIYRNPQNSSQ
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 SADGLRCAVSDVEMQEHYDEFFEEVFTEMEEKYGEVEEMNVCDNLGDHLVGNVYVKFRRE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 SADGLRCAVSDVEMQEHYDEFFEEVFTEMEEKYGEVEEMNVCDNLGDHLVGNVYVKFRRE
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE0 EDAEKAVIDLNNRWFNGQPIHAELSPVTDFREACCRQYEMGECTRGGFCNFMHLKPISRE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 EDAEKAVIDLNNRWFNGQPIHAELSPVTDFREACCRQYEMGECTRGGFCNFMHLKPISRE
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE0 LRRELYGRRRKKHRSRSRSRERRSRSRDRGRGGGGGGGGGGGGRERDRRRSRDRERSGRF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 LRRELYGRRRKKHRSRSRSRERRSRSRDRGRGGGGGGGGGGGGRERDRRRSRDRERSGRF
190 200 210 220 230 240
>>NP_001020374 (OMIM: 191317) splicing factor U2AF 35 kD (240 aa)
initn: 1638 init1: 1638 opt: 1638 Z-score: 1201.8 bits: 229.8 E(85289): 3.3e-60
Smith-Waterman score: 1638; 97.1% identity (98.8% similar) in 240 aa overlap (1-240:1-240)
10 20 30 40 50 60
pF1KE0 MAEYLASIFGTEKDKVNCSFYFKIGACRHGDRCSRLHNKPTFSQTIALLNIYRNPQNSSQ
:::::::::::::::::::::::::::::::::::::::::::::: . :::::::::.:
NP_001 MAEYLASIFGTEKDKVNCSFYFKIGACRHGDRCSRLHNKPTFSQTILIQNIYRNPQNSAQ
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 SADGLRCAVSDVEMQEHYDEFFEEVFTEMEEKYGEVEEMNVCDNLGDHLVGNVYVKFRRE
.::: .::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TADGSHCAVSDVEMQEHYDEFFEEVFTEMEEKYGEVEEMNVCDNLGDHLVGNVYVKFRRE
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE0 EDAEKAVIDLNNRWFNGQPIHAELSPVTDFREACCRQYEMGECTRGGFCNFMHLKPISRE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EDAEKAVIDLNNRWFNGQPIHAELSPVTDFREACCRQYEMGECTRGGFCNFMHLKPISRE
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE0 LRRELYGRRRKKHRSRSRSRERRSRSRDRGRGGGGGGGGGGGGRERDRRRSRDRERSGRF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LRRELYGRRRKKHRSRSRSRERRSRSRDRGRGGGGGGGGGGGGRERDRRRSRDRERSGRF
190 200 210 220 230 240
>>NP_001020375 (OMIM: 191317) splicing factor U2AF 35 kD (167 aa)
initn: 1180 init1: 1180 opt: 1180 Z-score: 874.1 bits: 168.6 E(85289): 6e-42
Smith-Waterman score: 1180; 100.0% identity (100.0% similar) in 167 aa overlap (74-240:1-167)
50 60 70 80 90 100
pF1KE0 QTIALLNIYRNPQNSSQSADGLRCAVSDVEMQEHYDEFFEEVFTEMEEKYGEVEEMNVCD
::::::::::::::::::::::::::::::
NP_001 MQEHYDEFFEEVFTEMEEKYGEVEEMNVCD
10 20 30
110 120 130 140 150 160
pF1KE0 NLGDHLVGNVYVKFRREEDAEKAVIDLNNRWFNGQPIHAELSPVTDFREACCRQYEMGEC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NLGDHLVGNVYVKFRREEDAEKAVIDLNNRWFNGQPIHAELSPVTDFREACCRQYEMGEC
40 50 60 70 80 90
170 180 190 200 210 220
pF1KE0 TRGGFCNFMHLKPISRELRRELYGRRRKKHRSRSRSRERRSRSRDRGRGGGGGGGGGGGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TRGGFCNFMHLKPISRELRRELYGRRRKKHRSRSRSRERRSRSRDRGRGGGGGGGGGGGG
100 110 120 130 140 150
230 240
pF1KE0 RERDRRRSRDRERSGRF
:::::::::::::::::
NP_001 RERDRRRSRDRERSGRF
160
>>XP_016883957 (OMIM: 191317) PREDICTED: splicing factor (207 aa)
initn: 889 init1: 889 opt: 889 Z-score: 663.8 bits: 130.0 E(85289): 3.1e-30
Smith-Waterman score: 1341; 83.3% identity (85.0% similar) in 240 aa overlap (1-240:1-207)
10 20 30 40 50 60
pF1KE0 MAEYLASIFGTEKDKVNCSFYFKIGACRHGDRCSRLHNKPTFSQTIALLNIYRNPQNSSQ
:::::::::::::::::::::::::::::::::::::::::::::: . :::::::::.:
XP_016 MAEYLASIFGTEKDKVNCSFYFKIGACRHGDRCSRLHNKPTFSQTILIQNIYRNPQNSAQ
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 SADGLRCAVSDVEMQEHYDEFFEEVFTEMEEKYGEVEEMNVCDNLGDHLVGNVYVKFRRE
.::: .::::::::::::::::: ::::
XP_016 TADGSHCAVSDVEMQEHYDEFFE---------------------------------FRRE
70 80
130 140 150 160 170 180
pF1KE0 EDAEKAVIDLNNRWFNGQPIHAELSPVTDFREACCRQYEMGECTRGGFCNFMHLKPISRE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EDAEKAVIDLNNRWFNGQPIHAELSPVTDFREACCRQYEMGECTRGGFCNFMHLKPISRE
90 100 110 120 130 140
190 200 210 220 230 240
pF1KE0 LRRELYGRRRKKHRSRSRSRERRSRSRDRGRGGGGGGGGGGGGRERDRRRSRDRERSGRF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LRRELYGRRRKKHRSRSRSRERRSRSRDRGRGGGGGGGGGGGGRERDRRRSRDRERSGRF
150 160 170 180 190 200
>>XP_011528045 (OMIM: 191317) PREDICTED: splicing factor (207 aa)
initn: 889 init1: 889 opt: 889 Z-score: 663.8 bits: 130.0 E(85289): 3.1e-30
Smith-Waterman score: 1380; 86.2% identity (86.2% similar) in 240 aa overlap (1-240:1-207)
10 20 30 40 50 60
pF1KE0 MAEYLASIFGTEKDKVNCSFYFKIGACRHGDRCSRLHNKPTFSQTIALLNIYRNPQNSSQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MAEYLASIFGTEKDKVNCSFYFKIGACRHGDRCSRLHNKPTFSQTIALLNIYRNPQNSSQ
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 SADGLRCAVSDVEMQEHYDEFFEEVFTEMEEKYGEVEEMNVCDNLGDHLVGNVYVKFRRE
::::::::::::::::::::::: ::::
XP_011 SADGLRCAVSDVEMQEHYDEFFE---------------------------------FRRE
70 80
130 140 150 160 170 180
pF1KE0 EDAEKAVIDLNNRWFNGQPIHAELSPVTDFREACCRQYEMGECTRGGFCNFMHLKPISRE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EDAEKAVIDLNNRWFNGQPIHAELSPVTDFREACCRQYEMGECTRGGFCNFMHLKPISRE
90 100 110 120 130 140
190 200 210 220 230 240
pF1KE0 LRRELYGRRRKKHRSRSRSRERRSRSRDRGRGGGGGGGGGGGGRERDRRRSRDRERSGRF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LRRELYGRRRKKHRSRSRSRERRSRSRDRGRGGGGGGGGGGGGRERDRRRSRDRERSGRF
150 160 170 180 190 200
>>NP_001035515 (OMIM: 601080) splicing factor U2AF 26 kD (181 aa)
initn: 688 init1: 666 opt: 680 Z-score: 514.1 bits: 102.1 E(85289): 6.7e-22
Smith-Waterman score: 892; 64.2% identity (74.8% similar) in 218 aa overlap (1-212:1-179)
10 20 30 40 50 60
pF1KE0 MAEYLASIFGTEKDKVNCSFYFKIGACRHGDRCSRLHNKPTFSQTIALLNIYRNPQNSSQ
:::::::::::::::::::::::::.::::::::::::::::::
NP_001 MAEYLASIFGTEKDKVNCSFYFKIGVCRHGDRCSRLHNKPTFSQ----------------
10 20 30 40
70 80 90 100 110 120
pF1KE0 SADGLRCAVSDVEMQEHYDEFFEEVFTEMEEKYGEVEEMNVCDNLGDHLVGNVYVKFRRE
:::::..:::::.::::::::::::::::::::::::
NP_001 -----------------------EVFTELQEKYGEIEEMNVCDNLGDHLVGNVYVKFRRE
50 60 70 80
130 140 150 160 170 180
pF1KE0 EDAEKAVIDLNNRWFNGQPIHAELSPVTDFREACCRQYEMGECTRGGFCNFMHLKPISRE
::.:.:: .:.::::::: .:.::::::::::.:::::::::::::::::::::.:::..
NP_001 EDGERAVAELSNRWFNGQAVHGELSPVTDFRESCCRQYEMGECTRGGFCNFMHLRPISQN
90 100 110 120 130 140
190 200 210 220 230
pF1KE0 LRRELYGR--RRK---KHRSRSRSRERRSR-SRDRGRGGGGGGGGGGGGRERDRRRSRDR
:.:.:::: ::. . .. . ::: : : :. .:
NP_001 LQRQLYGRGPRRRSPPRFHTGHHPRERNHRCSPDHWHGRF
150 160 170 180
240
pF1KE0 ERSGRF
>>XP_005274654 (OMIM: 300028) PREDICTED: U2 small nuclea (348 aa)
initn: 475 init1: 230 opt: 444 Z-score: 341.4 bits: 71.1 E(85289): 2.8e-12
Smith-Waterman score: 461; 35.1% identity (60.3% similar) in 239 aa overlap (12-234:28-265)
10 20 30 40
pF1KE0 MAEYLASIFGTEKDKVNCSFYFKIGACRHGDRCSRLHNKPTFSQ
:::..:: :: : :::: :::::: :: :: :
XP_005 MLDQAENELENGTTWQNPEPPVDFRVMEKDRANCPFYSKTGACRFGDRCSRKHNFPTSSP
10 20 30 40 50 60
50 60 70 80 90 100
pF1KE0 TIALLNIYRN---PQNSSQSAD-GLRCAVSDVEMQEHYDEFFEEVFTEMEEKYGEVEEMN
:. . ... . : .. : :. : ... .:.:.:. :... :.: ...
XP_005 TLLIKSMFTTFGMEQCRRDDYDPDASLEYSEEETYQQFLDFYEDVLPEFKN-VGKVIQFK
70 80 90 100 110
110 120 130 140 150 160
pF1KE0 VCDNLGDHLVGNVYVKFRREEDAEKAVIDLNNRWFNGQPIHAELSPVTDFREACCRQYEM
: :: :: :::::... ::. . :. .:.::. :. .. :. ::: .. : : .:.
XP_005 VSCNLEPHLRGNVYVQYQSEEECQAALSLFNGRWYAGRQLQCEFCPVTRWKMAICGLFEI
120 130 140 150 160 170
170 180 190 200
pF1KE0 GECTRGGFCNFMHL--KPISR--ELRRELYGRRRKKHRSRSRSRERRSR--------SRD
.: :: :::.:. .: .. : :..: . : ... ::: : ::
XP_005 QQCPRGKHCNFLHVFRNPNNEFWEANRDIYLSPDRTGSSFGKNSERRERMGHHDDYYSRL
180 190 200 210 220 230
210 220 230 240
pF1KE0 RGRGGGGGGGGGGGGRERDRRRSRDRERSGRF
::: . . . . : .:. :: :
XP_005 RGRRNPSPDHSYKRNGESERKSSRHRGKKSHKRTSKSRERHNSRSRGRNRDRSRDRSRGR
240 250 260 270 280 290
>>XP_011543892 (OMIM: 300028) PREDICTED: U2 small nuclea (348 aa)
initn: 475 init1: 230 opt: 444 Z-score: 341.4 bits: 71.1 E(85289): 2.8e-12
Smith-Waterman score: 461; 35.1% identity (60.3% similar) in 239 aa overlap (12-234:28-265)
10 20 30 40
pF1KE0 MAEYLASIFGTEKDKVNCSFYFKIGACRHGDRCSRLHNKPTFSQ
:::..:: :: : :::: :::::: :: :: :
XP_011 MLDQAENELENGTTWQNPEPPVDFRVMEKDRANCPFYSKTGACRFGDRCSRKHNFPTSSP
10 20 30 40 50 60
50 60 70 80 90 100
pF1KE0 TIALLNIYRN---PQNSSQSAD-GLRCAVSDVEMQEHYDEFFEEVFTEMEEKYGEVEEMN
:. . ... . : .. : :. : ... .:.:.:. :... :.: ...
XP_011 TLLIKSMFTTFGMEQCRRDDYDPDASLEYSEEETYQQFLDFYEDVLPEFKN-VGKVIQFK
70 80 90 100 110
110 120 130 140 150 160
pF1KE0 VCDNLGDHLVGNVYVKFRREEDAEKAVIDLNNRWFNGQPIHAELSPVTDFREACCRQYEM
: :: :: :::::... ::. . :. .:.::. :. .. :. ::: .. : : .:.
XP_011 VSCNLEPHLRGNVYVQYQSEEECQAALSLFNGRWYAGRQLQCEFCPVTRWKMAICGLFEI
120 130 140 150 160 170
170 180 190 200
pF1KE0 GECTRGGFCNFMHL--KPISR--ELRRELYGRRRKKHRSRSRSRERRSR--------SRD
.: :: :::.:. .: .. : :..: . : ... ::: : ::
XP_011 QQCPRGKHCNFLHVFRNPNNEFWEANRDIYLSPDRTGSSFGKNSERRERMGHHDDYYSRL
180 190 200 210 220 230
210 220 230 240
pF1KE0 RGRGGGGGGGGGGGGRERDRRRSRDRERSGRF
::: . . . . : .:. :: :
XP_011 RGRRNPSPDHSYKRNGESERKSSRHRGKKSHKRTSKSRERHNSRSRGRNRDRSRDRSRGR
240 250 260 270 280 290
>>XP_016885372 (OMIM: 300028) PREDICTED: U2 small nuclea (348 aa)
initn: 475 init1: 230 opt: 444 Z-score: 341.4 bits: 71.1 E(85289): 2.8e-12
Smith-Waterman score: 461; 35.1% identity (60.3% similar) in 239 aa overlap (12-234:28-265)
10 20 30 40
pF1KE0 MAEYLASIFGTEKDKVNCSFYFKIGACRHGDRCSRLHNKPTFSQ
:::..:: :: : :::: :::::: :: :: :
XP_016 MLDQAENELENGTTWQNPEPPVDFRVMEKDRANCPFYSKTGACRFGDRCSRKHNFPTSSP
10 20 30 40 50 60
50 60 70 80 90 100
pF1KE0 TIALLNIYRN---PQNSSQSAD-GLRCAVSDVEMQEHYDEFFEEVFTEMEEKYGEVEEMN
:. . ... . : .. : :. : ... .:.:.:. :... :.: ...
XP_016 TLLIKSMFTTFGMEQCRRDDYDPDASLEYSEEETYQQFLDFYEDVLPEFKN-VGKVIQFK
70 80 90 100 110
110 120 130 140 150 160
pF1KE0 VCDNLGDHLVGNVYVKFRREEDAEKAVIDLNNRWFNGQPIHAELSPVTDFREACCRQYEM
: :: :: :::::... ::. . :. .:.::. :. .. :. ::: .. : : .:.
XP_016 VSCNLEPHLRGNVYVQYQSEEECQAALSLFNGRWYAGRQLQCEFCPVTRWKMAICGLFEI
120 130 140 150 160 170
170 180 190 200
pF1KE0 GECTRGGFCNFMHL--KPISR--ELRRELYGRRRKKHRSRSRSRERRSR--------SRD
.: :: :::.:. .: .. : :..: . : ... ::: : ::
XP_016 QQCPRGKHCNFLHVFRNPNNEFWEANRDIYLSPDRTGSSFGKNSERRERMGHHDDYYSRL
180 190 200 210 220 230
210 220 230 240
pF1KE0 RGRGGGGGGGGGGGGRERDRRRSRDRERSGRF
::: . . . . : .:. :: :
XP_016 RGRRNPSPDHSYKRNGESERKSSRHRGKKSHKRTSKSRERHNSRSRGRNRDRSRDRSRGR
240 250 260 270 280 290
>>XP_016885371 (OMIM: 300028) PREDICTED: U2 small nuclea (348 aa)
initn: 475 init1: 230 opt: 444 Z-score: 341.4 bits: 71.1 E(85289): 2.8e-12
Smith-Waterman score: 461; 35.1% identity (60.3% similar) in 239 aa overlap (12-234:28-265)
10 20 30 40
pF1KE0 MAEYLASIFGTEKDKVNCSFYFKIGACRHGDRCSRLHNKPTFSQ
:::..:: :: : :::: :::::: :: :: :
XP_016 MLDQAENELENGTTWQNPEPPVDFRVMEKDRANCPFYSKTGACRFGDRCSRKHNFPTSSP
10 20 30 40 50 60
50 60 70 80 90 100
pF1KE0 TIALLNIYRN---PQNSSQSAD-GLRCAVSDVEMQEHYDEFFEEVFTEMEEKYGEVEEMN
:. . ... . : .. : :. : ... .:.:.:. :... :.: ...
XP_016 TLLIKSMFTTFGMEQCRRDDYDPDASLEYSEEETYQQFLDFYEDVLPEFKN-VGKVIQFK
70 80 90 100 110
110 120 130 140 150 160
pF1KE0 VCDNLGDHLVGNVYVKFRREEDAEKAVIDLNNRWFNGQPIHAELSPVTDFREACCRQYEM
: :: :: :::::... ::. . :. .:.::. :. .. :. ::: .. : : .:.
XP_016 VSCNLEPHLRGNVYVQYQSEEECQAALSLFNGRWYAGRQLQCEFCPVTRWKMAICGLFEI
120 130 140 150 160 170
170 180 190 200
pF1KE0 GECTRGGFCNFMHL--KPISR--ELRRELYGRRRKKHRSRSRSRERRSR--------SRD
.: :: :::.:. .: .. : :..: . : ... ::: : ::
XP_016 QQCPRGKHCNFLHVFRNPNNEFWEANRDIYLSPDRTGSSFGKNSERRERMGHHDDYYSRL
180 190 200 210 220 230
210 220 230 240
pF1KE0 RGRGGGGGGGGGGGGRERDRRRSRDRERSGRF
::: . . . . : .:. :: :
XP_016 RGRRNPSPDHSYKRNGESERKSSRHRGKKSHKRTSKSRERHNSRSRGRNRDRSRDRSRGR
240 250 260 270 280 290
240 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Wed Nov 2 18:19:17 2016 done: Wed Nov 2 18:19:18 2016
Total Scan time: 6.120 Total Display time: -0.010
Function used was FASTA [36.3.4 Apr, 2011]