FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE4339, 351 aa 1>>>pF1KE4339 351 - 351 aa - 351 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.4535+/-0.000966; mu= 15.1858+/- 0.058 mean_var=64.3099+/-12.687, 0's: 0 Z-trim(104.1): 21 B-trim: 0 in 0/50 Lambda= 0.159932 statistics sampled from 7708 (7717) to 7708 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.615), E-opt: 0.2 (0.237), width: 16 Scan time: 2.610 The best scores are: opt bits E(32554) CCDS9836.1 EIF2B2 gene_id:8892|Hs108|chr14 ( 351) 2262 530.9 6.3e-151 CCDS31924.1 EIF2B1 gene_id:1967|Hs108|chr12 ( 305) 319 82.5 5e-16 CCDS46244.1 EIF2B4 gene_id:8890|Hs108|chr2 ( 522) 295 77.1 3.7e-14 CCDS33164.1 EIF2B4 gene_id:8890|Hs108|chr2 ( 523) 295 77.1 3.7e-14 CCDS46245.1 EIF2B4 gene_id:8890|Hs108|chr2 ( 543) 295 77.1 3.9e-14 CCDS82432.1 EIF2B4 gene_id:8890|Hs108|chr2 ( 544) 295 77.1 3.9e-14 >>CCDS9836.1 EIF2B2 gene_id:8892|Hs108|chr14 (351 aa) initn: 2262 init1: 2262 opt: 2262 Z-score: 2823.1 bits: 530.9 E(32554): 6.3e-151 Smith-Waterman score: 2262; 99.4% identity (100.0% similar) in 351 aa overlap (1-351:1-351) 10 20 30 40 50 60 pF1KE4 MPGSAAKGSELSERIESFVETLKRGGGPRSSEEMARETLGLLRQIITDHRWSNAGELMEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS98 MPGSAAKGSELSERIESFVETLKRGGGPRSSEEMARETLGLLRQIITDHRWSNAGELMEL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 IRREGRRMTAAQPSETTVGNMVRRVLKIIREEYGRLHGRTDESDQQESLHKLLTSGGLNE :::::::::::::::::::::::::::::::::::::::.:::::::::::::::::::: CCDS98 IRREGRRMTAAQPSETTVGNMVRRVLKIIREEYGRLHGRSDESDQQESLHKLLTSGGLNE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 DFSFHYAQLQSNIIEAINELLVELEGTMENIAAQALEHIHSNEVIMTIGFSRTVEAFLKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS98 DFSFHYAQLQSNIIEAINELLVELEGTMENIAAQALEHIHSNEVIMTIGFSRTVEAFLKE 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 AARKRKFHVIVAECAPFCQGHEMAVNLSKAGIETTVMTDAAIFAVMSRVNKVIIGTKTIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS98 AARKRKFHVIVAECAPFCQGHEMAVNLSKAGIETTVMTDAAIFAVMSRVNKVIIGTKTIL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 ANGALRAVTGTHTLALAAKHHSTPLIVCAPMFKLSPQFPNEEDSFHKFVAPEEVLPFTEG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS98 ANGALRAVTGTHTLALAAKHHSTPLIVCAPMFKLSPQFPNEEDSFHKFVAPEEVLPFTEG 250 260 270 280 290 300 310 320 330 340 350 pF1KE4 DILEKVSVHCPVFDYVPPELITLFISNIGGNSPSYIYRLMSELYHPDDHVL :::::::::::::::::::::::::::::::.::::::::::::::::::: CCDS98 DILEKVSVHCPVFDYVPPELITLFISNIGGNAPSYIYRLMSELYHPDDHVL 310 320 330 340 350 >>CCDS31924.1 EIF2B1 gene_id:1967|Hs108|chr12 (305 aa) initn: 235 init1: 166 opt: 319 Z-score: 401.2 bits: 82.5 E(32554): 5e-16 Smith-Waterman score: 327; 27.3% identity (60.7% similar) in 308 aa overlap (56-344:5-304) 30 40 50 60 70 80 pF1KE4 GGPRSSEEMARETLGLLRQIITDHRWSNAGELMELIRREGRRMTAAQPSETTVGNMVRRV ::.: .. . .. .:. ... .: . CCDS31 MDDKELIEYFKSQMKE----DPDMASAVAAIRTL 10 20 30 90 100 110 120 pF1KE4 LKIIREEYGR-LHG-RTDESDQQESLHKL-----LTSGG---------LNEDFSFHYAQL :...... :. ..: :.. .. :.: . ..::: . ..: :.. CCDS31 LEFLKRDKGETIQGLRANLTSAIETLCGVDSSVAVSSGGELFLRFISLASLEYS-DYSKC 40 50 60 70 80 130 140 150 160 170 180 pF1KE4 QSNIIEAINELLVELEGTMENIAAQALEHIHSNEVIMTIGFSRTVEAFLKEA-ARKRKFH .. .:: . .: .. . ..:: :... .:.: ..::.: :. : : :..: CCDS31 KKIMIERGELFLRRISLSRNKIADLCHTFIKDGATILTHAYSRVVLRVLEAAVAAKKRFS 90 100 110 120 130 140 190 200 210 220 230 240 pF1KE4 VIVAECAPFCQGHEMAVNLSKAGIETTVMTDAAIFAVMSRVNKVIIGTKTILANGALRAV : :.: : .:..:: : . .. .::. :::. .: ... ::.:.. .. ::.. CCDS31 VYVTESQPDLSGKKMAKALCHLNVPVTVVLDAAVGYIMEKADLVIVGAEGVVENGGIINK 150 160 170 180 190 200 250 260 270 280 290 300 pF1KE4 TGTHTLALAAKHHSTPLIVCAPMFKLSPQFP-NEEDSFHKFVAPEEVLPFTE-GDILEKV ::. .:. :: .. :. : : ::. :: :..: :: ..: .. :. :.. CCDS31 IGTNQMAVCAKAQNKPFYVVAESFKFVRLFPLNQQDVPDKFKYKADTLKVAQTGQDLKE- 210 220 230 240 250 260 310 320 330 340 350 pF1KE4 SVHCPVFDYVPPELITLFISNIGGNSPSYIYRLMSELYHPDDHVL : : ::. : ::::.....: .:: . . .:: CCDS31 -EH-PWVDYTAPSLITLLFTDLGVLTPSAVSDELIKLYL 270 280 290 300 >>CCDS46244.1 EIF2B4 gene_id:8890|Hs108|chr2 (522 aa) initn: 196 init1: 155 opt: 295 Z-score: 367.6 bits: 77.1 E(32554): 3.7e-14 Smith-Waterman score: 295; 28.4% identity (62.9% similar) in 232 aa overlap (109-329:279-504) 80 90 100 110 120 130 pF1KE4 GNMVRRVLKIIREEYGRLHGRTDESDQQESLHKLLTSGGLNEDFSFHYAQLQSNIIEAIN :.: .:: : .. ..:.. : . .. CCDS46 RDLVNKLKPYMSFLTQCRPLSASMHNAIKFLNKEITSVGSSKREEEAKSELRAAIDRYVQ 250 260 270 280 290 300 140 150 160 170 180 190 pF1KE4 ELLVELEGTMENIAAQALEHIHSNEVIMTIGFSRTVEAFLKEA-ARKRKFHVIVAECAPF : .: . . :. : ..: ...::.. : : : .:.:: .. :.:.:.:.. :. CCDS46 EKIVL---AAQAISRFAYQKISNGDVILVYGCSSLVSRILQEAWTEGRRFRVVVVDSRPW 310 320 330 340 350 360 200 210 220 230 240 250 pF1KE4 CQGHEMAVNLSKAGIETTVMTDAAIFAVMSRVNKVIIGTKTILANGALRAVTGTHTLALA .:.. .: .::. .. . : :. .:.::..:....::::.. . .:: :::. CCDS46 LEGRHTLRSLVHAGVPASYLLIPAASYVLPEVSKVLLGAHALLANGSVMSRVGTAQLALV 370 380 390 400 410 420 260 270 280 290 300 310 pF1KE4 AKHHSTPLIVCAPMFKLSPQFPNEEDSF--HKFVAPEEVLPFTEGD--ILEKVSVHCP-- :. :..:..:: .:. . . :.: ... :.. : .:. : . . : CCDS46 ARAHNVPVLVCCETYKFCERV--QTDAFVSNELDDPDD-LQCKRGEHVALANWQNHASLR 430 440 450 460 470 480 320 330 340 350 pF1KE4 ----VFDYVPPELITLFISNIGGNSPSYIYRLMSELYHPDDHVL :.: .::::. : :...: CCDS46 LLNLVYDVTPPELVDLVITELGMIPCSSVPVVLRVKSSDQ 490 500 510 520 >>CCDS33164.1 EIF2B4 gene_id:8890|Hs108|chr2 (523 aa) initn: 196 init1: 155 opt: 295 Z-score: 367.6 bits: 77.1 E(32554): 3.7e-14 Smith-Waterman score: 295; 28.4% identity (62.9% similar) in 232 aa overlap (109-329:280-505) 80 90 100 110 120 130 pF1KE4 GNMVRRVLKIIREEYGRLHGRTDESDQQESLHKLLTSGGLNEDFSFHYAQLQSNIIEAIN :.: .:: : .. ..:.. : . .. CCDS33 RDLVNKLKPYMSFLTQCRPLSASMHNAIKFLNKEITSVGSSKREEEAKSELRAAIDRYVQ 250 260 270 280 290 300 140 150 160 170 180 190 pF1KE4 ELLVELEGTMENIAAQALEHIHSNEVIMTIGFSRTVEAFLKEA-ARKRKFHVIVAECAPF : .: . . :. : ..: ...::.. : : : .:.:: .. :.:.:.:.. :. CCDS33 EKIVL---AAQAISRFAYQKISNGDVILVYGCSSLVSRILQEAWTEGRRFRVVVVDSRPW 310 320 330 340 350 360 200 210 220 230 240 250 pF1KE4 CQGHEMAVNLSKAGIETTVMTDAAIFAVMSRVNKVIIGTKTILANGALRAVTGTHTLALA .:.. .: .::. .. . : :. .:.::..:....::::.. . .:: :::. CCDS33 LEGRHTLRSLVHAGVPASYLLIPAASYVLPEVSKVLLGAHALLANGSVMSRVGTAQLALV 370 380 390 400 410 420 260 270 280 290 300 310 pF1KE4 AKHHSTPLIVCAPMFKLSPQFPNEEDSF--HKFVAPEEVLPFTEGD--ILEKVSVHCP-- :. :..:..:: .:. . . :.: ... :.. : .:. : . . : CCDS33 ARAHNVPVLVCCETYKFCERV--QTDAFVSNELDDPDD-LQCKRGEHVALANWQNHASLR 430 440 450 460 470 480 320 330 340 350 pF1KE4 ----VFDYVPPELITLFISNIGGNSPSYIYRLMSELYHPDDHVL :.: .::::. : :...: CCDS33 LLNLVYDVTPPELVDLVITELGMIPCSSVPVVLRVKSSDQ 490 500 510 520 >>CCDS46245.1 EIF2B4 gene_id:8890|Hs108|chr2 (543 aa) initn: 196 init1: 155 opt: 295 Z-score: 367.3 bits: 77.1 E(32554): 3.9e-14 Smith-Waterman score: 295; 28.4% identity (62.9% similar) in 232 aa overlap (109-329:300-525) 80 90 100 110 120 130 pF1KE4 GNMVRRVLKIIREEYGRLHGRTDESDQQESLHKLLTSGGLNEDFSFHYAQLQSNIIEAIN :.: .:: : .. ..:.. : . .. CCDS46 RDLVNKLKPYMSFLTQCRPLSASMHNAIKFLNKEITSVGSSKREEEAKSELRAAIDRYVQ 270 280 290 300 310 320 140 150 160 170 180 190 pF1KE4 ELLVELEGTMENIAAQALEHIHSNEVIMTIGFSRTVEAFLKEA-ARKRKFHVIVAECAPF : .: . . :. : ..: ...::.. : : : .:.:: .. :.:.:.:.. :. CCDS46 EKIVL---AAQAISRFAYQKISNGDVILVYGCSSLVSRILQEAWTEGRRFRVVVVDSRPW 330 340 350 360 370 380 200 210 220 230 240 250 pF1KE4 CQGHEMAVNLSKAGIETTVMTDAAIFAVMSRVNKVIIGTKTILANGALRAVTGTHTLALA .:.. .: .::. .. . : :. .:.::..:....::::.. . .:: :::. CCDS46 LEGRHTLRSLVHAGVPASYLLIPAASYVLPEVSKVLLGAHALLANGSVMSRVGTAQLALV 390 400 410 420 430 440 260 270 280 290 300 310 pF1KE4 AKHHSTPLIVCAPMFKLSPQFPNEEDSF--HKFVAPEEVLPFTEGD--ILEKVSVHCP-- :. :..:..:: .:. . . :.: ... :.. : .:. : . . : CCDS46 ARAHNVPVLVCCETYKFCERV--QTDAFVSNELDDPDD-LQCKRGEHVALANWQNHASLR 450 460 470 480 490 500 320 330 340 350 pF1KE4 ----VFDYVPPELITLFISNIGGNSPSYIYRLMSELYHPDDHVL :.: .::::. : :...: CCDS46 LLNLVYDVTPPELVDLVITELGMIPCSSVPVVLRVKSSDQ 510 520 530 540 >>CCDS82432.1 EIF2B4 gene_id:8890|Hs108|chr2 (544 aa) initn: 196 init1: 155 opt: 295 Z-score: 367.3 bits: 77.1 E(32554): 3.9e-14 Smith-Waterman score: 295; 28.4% identity (62.9% similar) in 232 aa overlap (109-329:301-526) 80 90 100 110 120 130 pF1KE4 GNMVRRVLKIIREEYGRLHGRTDESDQQESLHKLLTSGGLNEDFSFHYAQLQSNIIEAIN :.: .:: : .. ..:.. : . .. CCDS82 RDLVNKLKPYMSFLTQCRPLSASMHNAIKFLNKEITSVGSSKREEEAKSELRAAIDRYVQ 280 290 300 310 320 330 140 150 160 170 180 190 pF1KE4 ELLVELEGTMENIAAQALEHIHSNEVIMTIGFSRTVEAFLKEA-ARKRKFHVIVAECAPF : .: . . :. : ..: ...::.. : : : .:.:: .. :.:.:.:.. :. CCDS82 EKIVL---AAQAISRFAYQKISNGDVILVYGCSSLVSRILQEAWTEGRRFRVVVVDSRPW 340 350 360 370 380 200 210 220 230 240 250 pF1KE4 CQGHEMAVNLSKAGIETTVMTDAAIFAVMSRVNKVIIGTKTILANGALRAVTGTHTLALA .:.. .: .::. .. . : :. .:.::..:....::::.. . .:: :::. CCDS82 LEGRHTLRSLVHAGVPASYLLIPAASYVLPEVSKVLLGAHALLANGSVMSRVGTAQLALV 390 400 410 420 430 440 260 270 280 290 300 310 pF1KE4 AKHHSTPLIVCAPMFKLSPQFPNEEDSF--HKFVAPEEVLPFTEGD--ILEKVSVHCP-- :. :..:..:: .:. . . :.: ... :.. : .:. : . . : CCDS82 ARAHNVPVLVCCETYKFCERV--QTDAFVSNELDDPDD-LQCKRGEHVALANWQNHASLR 450 460 470 480 490 500 320 330 340 350 pF1KE4 ----VFDYVPPELITLFISNIGGNSPSYIYRLMSELYHPDDHVL :.: .::::. : :...: CCDS82 LLNLVYDVTPPELVDLVITELGMIPCSSVPVVLRVKSSDQ 510 520 530 540 351 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 02:12:00 2016 done: Sun Nov 6 02:12:01 2016 Total Scan time: 2.610 Total Display time: 0.010 Function used was FASTA [36.3.4 Apr, 2011]