FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE2149, 607 aa 1>>>pF1KE2149 607 - 607 aa - 607 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 14.5230+/-0.000438; mu= -23.5361+/- 0.027 mean_var=569.6749+/-118.454, 0's: 0 Z-trim(124.7): 106 B-trim: 1501 in 1/60 Lambda= 0.053735 statistics sampled from 46870 (47002) to 46870 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.812), E-opt: 0.2 (0.551), width: 16 Scan time: 13.290 The best scores are: opt bits E(85289) NP_004747 (OMIM: 604018) numb-like protein isoform ( 609) 4203 340.6 9.1e-93 NP_001276908 (OMIM: 604018) numb-like protein isof ( 568) 3896 316.8 1.3e-85 NP_001276909 (OMIM: 604018) numb-like protein isof ( 568) 3896 316.8 1.3e-85 NP_001005745 (OMIM: 603728) protein numb homolog i ( 592) 1820 155.9 3.7e-37 NP_003735 (OMIM: 603728) protein numb homolog isof ( 640) 1660 143.5 2.1e-33 NP_001005744 (OMIM: 603728) protein numb homolog i ( 603) 1423 125.1 6.8e-28 NP_001307043 (OMIM: 603728) protein numb homolog i ( 603) 1423 125.1 6.8e-28 NP_001005743 (OMIM: 603728) protein numb homolog i ( 651) 1263 112.7 3.9e-24 >>NP_004747 (OMIM: 604018) numb-like protein isoform a [ (609 aa) initn: 3057 init1: 3057 opt: 4203 Z-score: 1786.4 bits: 340.6 E(85289): 9.1e-93 Smith-Waterman score: 4203; 99.7% identity (99.7% similar) in 609 aa overlap (1-607:1-609) 10 20 30 40 50 60 pF1KE2 MSRSAAASGGPRRPERHLPPAPCGAPGPPETCRTEPDGAGTMNKLRQSLRRRKPAYVPEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 MSRSAAASGGPRRPERHLPPAPCGAPGPPETCRTEPDGAGTMNKLRQSLRRRKPAYVPEA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 SRPHQWQADEDAVRKGTCSFPVRYLGHVEVEESRGMHVCEDAVKKLKAMGRKSVKSVLWV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 SRPHQWQADEDAVRKGTCSFPVRYLGHVEVEESRGMHVCEDAVKKLKAMGRKSVKSVLWV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 SADGLRVVDDKTKDLLVDQTIEKVSFCAPDRNLDKAFSYICRDGTTRRWICHCFLALKDS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 SADGLRVVDDKTKDLLVDQTIEKVSFCAPDRNLDKAFSYICRDGTTRRWICHCFLALKDS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 GERLSHAVGCAFAACLERKQRREKECGVTAAFDASRTSFAREGSFRLSGGGRPAEREAPD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 GERLSHAVGCAFAACLERKQRREKECGVTAAFDASRTSFAREGSFRLSGGGRPAEREAPD 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 KKKAEAAAAPTVAPGPAQPGHVSPTPATTSPGEKGEAGTPVAAGTTAAAIPRRHAPLEQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 KKKAEAAAAPTVAPGPAQPGHVSPTPATTSPGEKGEAGTPVAAGTTAAAIPRRHAPLEQL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 VRQGSFRGFPALSQKNSPFKRQLSLRLNELPSTLQRRTDFQVKGTVPEMEPPGAGDSDSI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 VRQGSFRGFPALSQKNSPFKRQLSLRLNELPSTLQRRTDFQVKGTVPEMEPPGAGDSDSI 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 NALCTQISSSFASAGAPAPGPPPATTGTSAWGEPSVPPAAAFQPGHKRTPSEAERWLEEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 NALCTQISSSFASAGAPAPGPPPATTGTSAWGEPSVPPAAAFQPGHKRTPSEAERWLEEV 370 380 390 400 410 420 430 440 450 460 470 pF1KE2 SQVAKAQQQQQQQQQQQQQQQQQQ--AASVAPVPTMPPALQPFPAPVGPFDAAPAQVAVF :::::::::::::::::::::::: :::::::::::::::::::::::::::::::::: NP_004 SQVAKAQQQQQQQQQQQQQQQQQQQQAASVAPVPTMPPALQPFPAPVGPFDAAPAQVAVF 430 440 450 460 470 480 480 490 500 510 520 530 pF1KE2 LPPPHMQPPFVPAYPGLGYPPMPRVPVVGITPSQMVANAFCSAAQLQPQPATLLGKAGAF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 LPPPHMQPPFVPAYPGLGYPPMPRVPVVGITPSQMVANAFCSAAQLQPQPATLLGKAGAF 490 500 510 520 530 540 540 550 560 570 580 590 pF1KE2 PPPAIPSAPGSQARPRPNGAPWPPEPAPAPAPELDPFEAQWAALEGKATVEKPSNPFSGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 PPPAIPSAPGSQARPRPNGAPWPPEPAPAPAPELDPFEAQWAALEGKATVEKPSNPFSGD 550 560 570 580 590 600 600 pF1KE2 LQKTFEIEL ::::::::: NP_004 LQKTFEIEL >>NP_001276908 (OMIM: 604018) numb-like protein isoform (568 aa) initn: 2750 init1: 2750 opt: 3896 Z-score: 1658.2 bits: 316.8 E(85289): 1.3e-85 Smith-Waterman score: 3896; 99.6% identity (99.6% similar) in 568 aa overlap (42-607:1-568) 20 30 40 50 60 70 pF1KE2 RRPERHLPPAPCGAPGPPETCRTEPDGAGTMNKLRQSLRRRKPAYVPEASRPHQWQADED :::::::::::::::::::::::::::::: NP_001 MNKLRQSLRRRKPAYVPEASRPHQWQADED 10 20 30 80 90 100 110 120 130 pF1KE2 AVRKGTCSFPVRYLGHVEVEESRGMHVCEDAVKKLKAMGRKSVKSVLWVSADGLRVVDDK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AVRKGTCSFPVRYLGHVEVEESRGMHVCEDAVKKLKAMGRKSVKSVLWVSADGLRVVDDK 40 50 60 70 80 90 140 150 160 170 180 190 pF1KE2 TKDLLVDQTIEKVSFCAPDRNLDKAFSYICRDGTTRRWICHCFLALKDSGERLSHAVGCA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TKDLLVDQTIEKVSFCAPDRNLDKAFSYICRDGTTRRWICHCFLALKDSGERLSHAVGCA 100 110 120 130 140 150 200 210 220 230 240 250 pF1KE2 FAACLERKQRREKECGVTAAFDASRTSFAREGSFRLSGGGRPAEREAPDKKKAEAAAAPT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FAACLERKQRREKECGVTAAFDASRTSFAREGSFRLSGGGRPAEREAPDKKKAEAAAAPT 160 170 180 190 200 210 260 270 280 290 300 310 pF1KE2 VAPGPAQPGHVSPTPATTSPGEKGEAGTPVAAGTTAAAIPRRHAPLEQLVRQGSFRGFPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VAPGPAQPGHVSPTPATTSPGEKGEAGTPVAAGTTAAAIPRRHAPLEQLVRQGSFRGFPA 220 230 240 250 260 270 320 330 340 350 360 370 pF1KE2 LSQKNSPFKRQLSLRLNELPSTLQRRTDFQVKGTVPEMEPPGAGDSDSINALCTQISSSF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LSQKNSPFKRQLSLRLNELPSTLQRRTDFQVKGTVPEMEPPGAGDSDSINALCTQISSSF 280 290 300 310 320 330 380 390 400 410 420 430 pF1KE2 ASAGAPAPGPPPATTGTSAWGEPSVPPAAAFQPGHKRTPSEAERWLEEVSQVAKAQQQQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ASAGAPAPGPPPATTGTSAWGEPSVPPAAAFQPGHKRTPSEAERWLEEVSQVAKAQQQQQ 340 350 360 370 380 390 440 450 460 470 480 pF1KE2 QQQQQQQQQQQQQ--AASVAPVPTMPPALQPFPAPVGPFDAAPAQVAVFLPPPHMQPPFV ::::::::::::: ::::::::::::::::::::::::::::::::::::::::::::: NP_001 QQQQQQQQQQQQQQQAASVAPVPTMPPALQPFPAPVGPFDAAPAQVAVFLPPPHMQPPFV 400 410 420 430 440 450 490 500 510 520 530 540 pF1KE2 PAYPGLGYPPMPRVPVVGITPSQMVANAFCSAAQLQPQPATLLGKAGAFPPPAIPSAPGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PAYPGLGYPPMPRVPVVGITPSQMVANAFCSAAQLQPQPATLLGKAGAFPPPAIPSAPGS 460 470 480 490 500 510 550 560 570 580 590 600 pF1KE2 QARPRPNGAPWPPEPAPAPAPELDPFEAQWAALEGKATVEKPSNPFSGDLQKTFEIEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QARPRPNGAPWPPEPAPAPAPELDPFEAQWAALEGKATVEKPSNPFSGDLQKTFEIEL 520 530 540 550 560 >>NP_001276909 (OMIM: 604018) numb-like protein isoform (568 aa) initn: 2750 init1: 2750 opt: 3896 Z-score: 1658.2 bits: 316.8 E(85289): 1.3e-85 Smith-Waterman score: 3896; 99.6% identity (99.6% similar) in 568 aa overlap (42-607:1-568) 20 30 40 50 60 70 pF1KE2 RRPERHLPPAPCGAPGPPETCRTEPDGAGTMNKLRQSLRRRKPAYVPEASRPHQWQADED :::::::::::::::::::::::::::::: NP_001 MNKLRQSLRRRKPAYVPEASRPHQWQADED 10 20 30 80 90 100 110 120 130 pF1KE2 AVRKGTCSFPVRYLGHVEVEESRGMHVCEDAVKKLKAMGRKSVKSVLWVSADGLRVVDDK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AVRKGTCSFPVRYLGHVEVEESRGMHVCEDAVKKLKAMGRKSVKSVLWVSADGLRVVDDK 40 50 60 70 80 90 140 150 160 170 180 190 pF1KE2 TKDLLVDQTIEKVSFCAPDRNLDKAFSYICRDGTTRRWICHCFLALKDSGERLSHAVGCA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TKDLLVDQTIEKVSFCAPDRNLDKAFSYICRDGTTRRWICHCFLALKDSGERLSHAVGCA 100 110 120 130 140 150 200 210 220 230 240 250 pF1KE2 FAACLERKQRREKECGVTAAFDASRTSFAREGSFRLSGGGRPAEREAPDKKKAEAAAAPT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FAACLERKQRREKECGVTAAFDASRTSFAREGSFRLSGGGRPAEREAPDKKKAEAAAAPT 160 170 180 190 200 210 260 270 280 290 300 310 pF1KE2 VAPGPAQPGHVSPTPATTSPGEKGEAGTPVAAGTTAAAIPRRHAPLEQLVRQGSFRGFPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VAPGPAQPGHVSPTPATTSPGEKGEAGTPVAAGTTAAAIPRRHAPLEQLVRQGSFRGFPA 220 230 240 250 260 270 320 330 340 350 360 370 pF1KE2 LSQKNSPFKRQLSLRLNELPSTLQRRTDFQVKGTVPEMEPPGAGDSDSINALCTQISSSF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LSQKNSPFKRQLSLRLNELPSTLQRRTDFQVKGTVPEMEPPGAGDSDSINALCTQISSSF 280 290 300 310 320 330 380 390 400 410 420 430 pF1KE2 ASAGAPAPGPPPATTGTSAWGEPSVPPAAAFQPGHKRTPSEAERWLEEVSQVAKAQQQQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ASAGAPAPGPPPATTGTSAWGEPSVPPAAAFQPGHKRTPSEAERWLEEVSQVAKAQQQQQ 340 350 360 370 380 390 440 450 460 470 480 pF1KE2 QQQQQQQQQQQQQ--AASVAPVPTMPPALQPFPAPVGPFDAAPAQVAVFLPPPHMQPPFV ::::::::::::: ::::::::::::::::::::::::::::::::::::::::::::: NP_001 QQQQQQQQQQQQQQQAASVAPVPTMPPALQPFPAPVGPFDAAPAQVAVFLPPPHMQPPFV 400 410 420 430 440 450 490 500 510 520 530 540 pF1KE2 PAYPGLGYPPMPRVPVVGITPSQMVANAFCSAAQLQPQPATLLGKAGAFPPPAIPSAPGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PAYPGLGYPPMPRVPVVGITPSQMVANAFCSAAQLQPQPATLLGKAGAFPPPAIPSAPGS 460 470 480 490 500 510 550 560 570 580 590 600 pF1KE2 QARPRPNGAPWPPEPAPAPAPELDPFEAQWAALEGKATVEKPSNPFSGDLQKTFEIEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QARPRPNGAPWPPEPAPAPAPELDPFEAQWAALEGKATVEKPSNPFSGDLQKTFEIEL 520 530 540 550 560 >>NP_001005745 (OMIM: 603728) protein numb homolog isofo (592 aa) initn: 1943 init1: 1174 opt: 1820 Z-score: 788.2 bits: 155.9 E(85289): 3.7e-37 Smith-Waterman score: 2068; 56.9% identity (72.4% similar) in 624 aa overlap (42-607:1-592) 20 30 40 50 60 70 pF1KE2 RRPERHLPPAPCGAPGPPETCRTEPDGAGTMNKLRQSLRRRKPAYVPEASRPHQWQADED :::::::.::.: .::::::::::::.::. NP_001 MNKLRQSFRRKKDVYVPEASRPHQWQTDEE 10 20 30 80 90 100 110 120 130 pF1KE2 AVRKGTCSFPVRYLGHVEVEESRGMHVCEDAVKKLKAMGRKSVKSVLWVSADGLRVVDDK .:: : :::::.:::::::.::::::.::::::.::: :.:.::.:::::::::::::.: NP_001 GVRTGKCSFPVKYLGHVEVDESRGMHICEDAVKRLKATGKKAVKAVLWVSADGLRVVDEK 40 50 60 70 80 90 140 150 160 170 180 190 pF1KE2 TKDLLVDQTIEKVSFCAPDRNLDKAFSYICRDGTTRRWICHCFLALKDSGERLSHAVGCA ::::.::::::::::::::::.:.:::::::::::::::::::.:.::.::::::::::: NP_001 TKDLIVDQTIEKVSFCAPDRNFDRAFSYICRDGTTRRWICHCFMAVKDTGERLSHAVGCA 100 110 120 130 140 150 200 210 220 230 240 pF1KE2 FAACLERKQRREKECGVTAAFDASRTSFAREGSFRLSGGGRPAEREA-----PDKKKAEA :::::::::.:::::::::.::::::.:.::::::.. . . :::: : ::::. NP_001 FAACLERKQKREKECGVTATFDASRTTFTREGSFRVTTATEQAEREEIMKQMQDAKKAET 160 170 180 190 200 210 250 260 270 280 290 300 pF1KE2 ---AAAPTVAPGPAQPGHVSPTPATTSPGEKGEAGTPVAAGTTAAAIPRRHAPLEQLVRQ ... .:::: . :. ::: :.. . : ..: ::::::::.:::.:: NP_001 DKIVVGSSVAPGNTAPSPSSPTSPTSDATTSLEMNNP-------HAIPRRHAPIEQLARQ 220 230 240 250 260 310 320 330 340 350 360 pF1KE2 GSFRGFPALSQKNSPFKRQLSLRLNELPSTLQRRTDFQVKGTVPEMEPPGAGDSDSINAL :::::::::::: ::::::::::.::::::.::.::: .:..:::.: :...::..: NP_001 GSFRGFPALSQKMSPFKRQLSLRINELPSTMQRKTDFPIKNAVPEVE----GEAESISSL 270 280 290 300 310 370 380 390 400 410 pF1KE2 CTQISSSFASAGAP---APGPPPATT---------GTSAWGEPS-VPPAAAFQPGHKRTP :.::...:.. : :: :.:. :: ::. : . . :: ::.::: NP_001 CSQITNAFSTPEDPFSSAPMTKPVTVVAPQSPTFQGTE-WGQSSGAASPGLFQAGHRRTP 320 330 340 350 360 370 420 430 440 450 460 470 pF1KE2 SEAERWLEEVSQVAKAQQQQQQQQQQQQQQQQQQAASVAPVPTMPPALQPFPAPVGPFDA :::.:::::::. ..::: : ::.:: . :.::: : . : NP_001 SEADRWLEEVSKSVRAQQPQ---------------ASAAP---LQPVLQPPPPTAISQPA 380 390 400 410 420 480 490 500 510 pF1KE2 APAQVAVFL---P-P----PHMQPPFVPA--YP-GLGYP-PMPRVPVVGITPSQMVANAF .: : .:: : : : .:: :::: :: . :.: : : ::::::::::::::.: NP_001 SPFQGNAFLTSQPVPVGVVPALQPAFVPAQSYPVANGMPYPAPNVPVVGITPSQMVANVF 430 440 450 460 470 480 520 530 540 550 pF1KE2 CSAAQLQ---PQPATLLGKAGAFP--------------PPAIPSAPGSQA-----RPRPN .:.. : :. . : . .:: ::: :: : : NP_001 GTAGHPQAAHPHQSPSLVRQQTFPHYEASSATTSPFFKPPA-QHLNGSAAFNGVDDGRLA 490 500 510 520 530 560 570 580 590 600 pF1KE2 GAPWPPEPAPAPAPELDPFEAQWAALEGKA---TVEKPSNPFSGDLQKTFEIEL .: : .:. . .:::::::::::.:. : .:.::::.:::::::::: NP_001 SADRHTE-VPTGTCPVDPFEAQWAALENKSKQRTNPSPTNPFSSDLQKTFEIEL 540 550 560 570 580 590 >>NP_003735 (OMIM: 603728) protein numb homolog isoform (640 aa) initn: 1943 init1: 1174 opt: 1660 Z-score: 720.7 bits: 143.5 E(85289): 2.1e-33 Smith-Waterman score: 1850; 54.3% identity (69.4% similar) in 591 aa overlap (42-549:1-562) 20 30 40 50 60 70 pF1KE2 RRPERHLPPAPCGAPGPPETCRTEPDGAGTMNKLRQSLRRRKPAYVPEASRPHQWQADED :::::::.::.: .::::::::::::.::. NP_003 MNKLRQSFRRKKDVYVPEASRPHQWQTDEE 10 20 30 80 90 100 110 120 130 pF1KE2 AVRKGTCSFPVRYLGHVEVEESRGMHVCEDAVKKLKAMGRKSVKSVLWVSADGLRVVDDK .:: : :::::.:::::::.::::::.::::::.::: :.:.::.:::::::::::::.: NP_003 GVRTGKCSFPVKYLGHVEVDESRGMHICEDAVKRLKATGKKAVKAVLWVSADGLRVVDEK 40 50 60 70 80 90 140 150 160 170 180 190 pF1KE2 TKDLLVDQTIEKVSFCAPDRNLDKAFSYICRDGTTRRWICHCFLALKDSGERLSHAVGCA ::::.::::::::::::::::.:.:::::::::::::::::::.:.::.::::::::::: NP_003 TKDLIVDQTIEKVSFCAPDRNFDRAFSYICRDGTTRRWICHCFMAVKDTGERLSHAVGCA 100 110 120 130 140 150 200 210 220 230 240 pF1KE2 FAACLERKQRREKECGVTAAFDASRTSFAREGSFRLSGGGRPAEREA-----PDKKKAEA :::::::::.:::::::::.::::::.:.::::::.. . . :::: : ::::. NP_003 FAACLERKQKREKECGVTATFDASRTTFTREGSFRVTTATEQAEREEIMKQMQDAKKAET 160 170 180 190 200 210 250 260 270 280 290 300 pF1KE2 ---AAAPTVAPGPAQPGHVSPTPATTSPGEKGEAGTPVAAGTTAAAIPRRHAPLEQLVRQ ... .:::: . :. ::: :.. . : ..: ::::::::.:::.:: NP_003 DKIVVGSSVAPGNTAPSPSSPTSPTSDATTSLEMNNP-------HAIPRRHAPIEQLARQ 220 230 240 250 260 310 320 330 340 350 360 pF1KE2 GSFRGFPALSQKNSPFKRQLSLRLNELPSTLQRRTDFQVKGTVPEMEPPGAGDSDSINAL :::::::::::: ::::::::::.::::::.::.::: .:..:::.: :...::..: NP_003 GSFRGFPALSQKMSPFKRQLSLRINELPSTMQRKTDFPIKNAVPEVE----GEAESISSL 270 280 290 300 310 370 380 pF1KE2 CTQISSSFAS-----AGAP--------APGPP----------------PATTGT------ :.::...:.. ..:: :: : :: :. NP_003 CSQITNAFSTPEDPFSSAPMTKPVTVVAPQSPTFQANGTDSAFHVLAKPAHTALAPVAMP 320 330 340 350 360 370 390 400 410 420 pF1KE2 ------------------------SAWGEPS-VPPAAAFQPGHKRTPSEAERWLEEVSQV . ::. : . . :: ::.::::::.:::::::. NP_003 VRETNPWAHAPDAANKEIAATCSGTEWGQSSGAASPGLFQAGHRRTPSEADRWLEEVSKS 380 390 400 410 420 430 430 440 450 460 470 480 pF1KE2 AKAQQQQQQQQQQQQQQQQQQAASVAPVPTMPPALQPFPAPVGPFDAAPAQVAVFL---P ..::: : ::.:: . :.::: : . :.: : .:: : NP_003 VRAQQPQ---------------ASAAP---LQPVLQPPPPTAISQPASPFQGNAFLTSQP 440 450 460 470 480 490 500 510 520 pF1KE2 -P----PHMQPPFVPA--YP-GLGYP-PMPRVPVVGITPSQMVANAFCSAAQLQ---PQP : : .:: :::: :: . :.: : : ::::::::::::::.: .:.. : :. NP_003 VPVGVVPALQPAFVPAQSYPVANGMPYPAPNVPVVGITPSQMVANVFGTAGHPQAAHPHQ 490 500 510 520 530 540 530 540 550 560 570 580 pF1KE2 ATLLGKAGAFPPPAIPSAPGSQARPRPNGAPWPPEPAPAPAPELDPFEAQWAALEGKATV . : . .:: :: : NP_003 SPSLVRQQTFPHYEASSATTSPFFKPPAQHLNGSAAFNGVDDGRLASADRHTEVPTGTCP 550 560 570 580 590 600 >>NP_001005744 (OMIM: 603728) protein numb homolog isofo (603 aa) initn: 1930 init1: 777 opt: 1423 Z-score: 621.8 bits: 125.1 E(85289): 6.8e-28 Smith-Waterman score: 2036; 55.9% identity (71.2% similar) in 635 aa overlap (42-607:1-603) 20 30 40 50 60 70 pF1KE2 RRPERHLPPAPCGAPGPPETCRTEPDGAGTMNKLRQSLRRRKPAYVPEASRPHQWQADED :::::::.::.: .::::::::::::.::. NP_001 MNKLRQSFRRKKDVYVPEASRPHQWQTDEE 10 20 30 80 90 100 110 120 pF1KE2 AVRKGTCSFPVRYLGHVEVEESRGMHVCEDAVKKLKA-----------MGRKSVKSVLWV .:: : :::::.:::::::.::::::.::::::.::: :.:.::.:::: NP_001 GVRTGKCSFPVKYLGHVEVDESRGMHICEDAVKRLKAERKFFKGFFGKTGKKAVKAVLWV 40 50 60 70 80 90 130 140 150 160 170 180 pF1KE2 SADGLRVVDDKTKDLLVDQTIEKVSFCAPDRNLDKAFSYICRDGTTRRWICHCFLALKDS :::::::::.:::::.::::::::::::::::.:.:::::::::::::::::::.:.::. NP_001 SADGLRVVDEKTKDLIVDQTIEKVSFCAPDRNFDRAFSYICRDGTTRRWICHCFMAVKDT 100 110 120 130 140 150 190 200 210 220 230 pF1KE2 GERLSHAVGCAFAACLERKQRREKECGVTAAFDASRTSFAREGSFRLSGGGRPAEREA-- ::::::::::::::::::::.:::::::::.::::::.:.::::::.. . . :::: NP_001 GERLSHAVGCAFAACLERKQKREKECGVTATFDASRTTFTREGSFRVTTATEQAEREEIM 160 170 180 190 200 210 240 250 260 270 280 290 pF1KE2 ---PDKKKAEA---AAAPTVAPGPAQPGHVSPTPATTSPGEKGEAGTPVAAGTTAAAIPR : ::::. ... .:::: . :. ::: :.. . : ..: :::: NP_001 KQMQDAKKAETDKIVVGSSVAPGNTAPSPSSPTSPTSDATTSLEMNNP-------HAIPR 220 230 240 250 260 300 310 320 330 340 350 pF1KE2 RHAPLEQLVRQGSFRGFPALSQKNSPFKRQLSLRLNELPSTLQRRTDFQVKGTVPEMEPP ::::.:::.:::::::::::::: ::::::::::.::::::.::.::: .:..:::.: NP_001 RHAPIEQLARQGSFRGFPALSQKMSPFKRQLSLRINELPSTMQRKTDFPIKNAVPEVE-- 270 280 290 300 310 320 360 370 380 390 pF1KE2 GAGDSDSINALCTQISSSFASAGAP---APGPPPATT---------GTSAWGEPS-VPPA :...::..::.::...:.. : :: :.:. :: ::. : . NP_001 --GEAESISSLCSQITNAFSTPEDPFSSAPMTKPVTVVAPQSPTFQGTE-WGQSSGAASP 330 340 350 360 370 400 410 420 430 440 450 pF1KE2 AAFQPGHKRTPSEAERWLEEVSQVAKAQQQQQQQQQQQQQQQQQQAASVAPVPTMPPALQ . :: ::.::::::.:::::::. ..::: : ::.:: . :.:: NP_001 GLFQAGHRRTPSEADRWLEEVSKSVRAQQPQ---------------ASAAP---LQPVLQ 380 390 400 410 420 460 470 480 490 500 pF1KE2 PFPAPVGPFDAAPAQVAVFL---P-P----PHMQPPFVPA--YP-GLGYP-PMPRVPVVG : : . :.: : .:: : : : .:: :::: :: . :.: : : ::::: NP_001 PPPPTAISQPASPFQGNAFLTSQPVPVGVVPALQPAFVPAQSYPVANGMPYPAPNVPVVG 430 440 450 460 470 480 510 520 530 540 550 pF1KE2 ITPSQMVANAFCSAAQLQ---PQPATLLGKAGAFP--------------PPAIPSAPGSQ :::::::::.: .:.. : :. . : . .:: ::: :: NP_001 ITPSQMVANVFGTAGHPQAAHPHQSPSLVRQQTFPHYEASSATTSPFFKPPA-QHLNGSA 490 500 510 520 530 560 570 580 590 600 pF1KE2 A-----RPRPNGAPWPPEPAPAPAPELDPFEAQWAALEGKA---TVEKPSNPFSGDLQKT : : .: : .:. . .:::::::::::.:. : .:.::::.::::: NP_001 AFNGVDDGRLASADRHTE-VPTGTCPVDPFEAQWAALENKSKQRTNPSPTNPFSSDLQKT 540 550 560 570 580 590 pF1KE2 FEIEL ::::: NP_001 FEIEL 600 >>NP_001307043 (OMIM: 603728) protein numb homolog isofo (603 aa) initn: 1930 init1: 777 opt: 1423 Z-score: 621.8 bits: 125.1 E(85289): 6.8e-28 Smith-Waterman score: 2036; 55.9% identity (71.2% similar) in 635 aa overlap (42-607:1-603) 20 30 40 50 60 70 pF1KE2 RRPERHLPPAPCGAPGPPETCRTEPDGAGTMNKLRQSLRRRKPAYVPEASRPHQWQADED :::::::.::.: .::::::::::::.::. NP_001 MNKLRQSFRRKKDVYVPEASRPHQWQTDEE 10 20 30 80 90 100 110 120 pF1KE2 AVRKGTCSFPVRYLGHVEVEESRGMHVCEDAVKKLKA-----------MGRKSVKSVLWV .:: : :::::.:::::::.::::::.::::::.::: :.:.::.:::: NP_001 GVRTGKCSFPVKYLGHVEVDESRGMHICEDAVKRLKAERKFFKGFFGKTGKKAVKAVLWV 40 50 60 70 80 90 130 140 150 160 170 180 pF1KE2 SADGLRVVDDKTKDLLVDQTIEKVSFCAPDRNLDKAFSYICRDGTTRRWICHCFLALKDS :::::::::.:::::.::::::::::::::::.:.:::::::::::::::::::.:.::. NP_001 SADGLRVVDEKTKDLIVDQTIEKVSFCAPDRNFDRAFSYICRDGTTRRWICHCFMAVKDT 100 110 120 130 140 150 190 200 210 220 230 pF1KE2 GERLSHAVGCAFAACLERKQRREKECGVTAAFDASRTSFAREGSFRLSGGGRPAEREA-- ::::::::::::::::::::.:::::::::.::::::.:.::::::.. . . :::: NP_001 GERLSHAVGCAFAACLERKQKREKECGVTATFDASRTTFTREGSFRVTTATEQAEREEIM 160 170 180 190 200 210 240 250 260 270 280 290 pF1KE2 ---PDKKKAEA---AAAPTVAPGPAQPGHVSPTPATTSPGEKGEAGTPVAAGTTAAAIPR : ::::. ... .:::: . :. ::: :.. . : ..: :::: NP_001 KQMQDAKKAETDKIVVGSSVAPGNTAPSPSSPTSPTSDATTSLEMNNP-------HAIPR 220 230 240 250 260 300 310 320 330 340 350 pF1KE2 RHAPLEQLVRQGSFRGFPALSQKNSPFKRQLSLRLNELPSTLQRRTDFQVKGTVPEMEPP ::::.:::.:::::::::::::: ::::::::::.::::::.::.::: .:..:::.: NP_001 RHAPIEQLARQGSFRGFPALSQKMSPFKRQLSLRINELPSTMQRKTDFPIKNAVPEVE-- 270 280 290 300 310 320 360 370 380 390 pF1KE2 GAGDSDSINALCTQISSSFASAGAP---APGPPPATT---------GTSAWGEPS-VPPA :...::..::.::...:.. : :: :.:. :: ::. : . NP_001 --GEAESISSLCSQITNAFSTPEDPFSSAPMTKPVTVVAPQSPTFQGTE-WGQSSGAASP 330 340 350 360 370 400 410 420 430 440 450 pF1KE2 AAFQPGHKRTPSEAERWLEEVSQVAKAQQQQQQQQQQQQQQQQQQAASVAPVPTMPPALQ . :: ::.::::::.:::::::. ..::: : ::.:: . :.:: NP_001 GLFQAGHRRTPSEADRWLEEVSKSVRAQQPQ---------------ASAAP---LQPVLQ 380 390 400 410 420 460 470 480 490 500 pF1KE2 PFPAPVGPFDAAPAQVAVFL---P-P----PHMQPPFVPA--YP-GLGYP-PMPRVPVVG : : . :.: : .:: : : : .:: :::: :: . :.: : : ::::: NP_001 PPPPTAISQPASPFQGNAFLTSQPVPVGVVPALQPAFVPAQSYPVANGMPYPAPNVPVVG 430 440 450 460 470 480 510 520 530 540 550 pF1KE2 ITPSQMVANAFCSAAQLQ---PQPATLLGKAGAFP--------------PPAIPSAPGSQ :::::::::.: .:.. : :. . : . .:: ::: :: NP_001 ITPSQMVANVFGTAGHPQAAHPHQSPSLVRQQTFPHYEASSATTSPFFKPPA-QHLNGSA 490 500 510 520 530 560 570 580 590 600 pF1KE2 A-----RPRPNGAPWPPEPAPAPAPELDPFEAQWAALEGKA---TVEKPSNPFSGDLQKT : : .: : .:. . .:::::::::::.:. : .:.::::.::::: NP_001 AFNGVDDGRLASADRHTE-VPTGTCPVDPFEAQWAALENKSKQRTNPSPTNPFSSDLQKT 540 550 560 570 580 590 pF1KE2 FEIEL ::::: NP_001 FEIEL 600 >>NP_001005743 (OMIM: 603728) protein numb homolog isofo (651 aa) initn: 1930 init1: 777 opt: 1263 Z-score: 554.3 bits: 112.7 E(85289): 3.9e-24 Smith-Waterman score: 1818; 53.3% identity (68.1% similar) in 602 aa overlap (42-549:1-573) 20 30 40 50 60 70 pF1KE2 RRPERHLPPAPCGAPGPPETCRTEPDGAGTMNKLRQSLRRRKPAYVPEASRPHQWQADED :::::::.::.: .::::::::::::.::. NP_001 MNKLRQSFRRKKDVYVPEASRPHQWQTDEE 10 20 30 80 90 100 110 120 pF1KE2 AVRKGTCSFPVRYLGHVEVEESRGMHVCEDAVKKLKA-----------MGRKSVKSVLWV .:: : :::::.:::::::.::::::.::::::.::: :.:.::.:::: NP_001 GVRTGKCSFPVKYLGHVEVDESRGMHICEDAVKRLKAERKFFKGFFGKTGKKAVKAVLWV 40 50 60 70 80 90 130 140 150 160 170 180 pF1KE2 SADGLRVVDDKTKDLLVDQTIEKVSFCAPDRNLDKAFSYICRDGTTRRWICHCFLALKDS :::::::::.:::::.::::::::::::::::.:.:::::::::::::::::::.:.::. NP_001 SADGLRVVDEKTKDLIVDQTIEKVSFCAPDRNFDRAFSYICRDGTTRRWICHCFMAVKDT 100 110 120 130 140 150 190 200 210 220 230 pF1KE2 GERLSHAVGCAFAACLERKQRREKECGVTAAFDASRTSFAREGSFRLSGGGRPAEREA-- ::::::::::::::::::::.:::::::::.::::::.:.::::::.. . . :::: NP_001 GERLSHAVGCAFAACLERKQKREKECGVTATFDASRTTFTREGSFRVTTATEQAEREEIM 160 170 180 190 200 210 240 250 260 270 280 290 pF1KE2 ---PDKKKAEA---AAAPTVAPGPAQPGHVSPTPATTSPGEKGEAGTPVAAGTTAAAIPR : ::::. ... .:::: . :. ::: :.. . : ..: :::: NP_001 KQMQDAKKAETDKIVVGSSVAPGNTAPSPSSPTSPTSDATTSLEMNNP-------HAIPR 220 230 240 250 260 300 310 320 330 340 350 pF1KE2 RHAPLEQLVRQGSFRGFPALSQKNSPFKRQLSLRLNELPSTLQRRTDFQVKGTVPEMEPP ::::.:::.:::::::::::::: ::::::::::.::::::.::.::: .:..:::.: NP_001 RHAPIEQLARQGSFRGFPALSQKMSPFKRQLSLRINELPSTMQRKTDFPIKNAVPEVE-- 270 280 290 300 310 320 360 370 380 pF1KE2 GAGDSDSINALCTQISSSFAS-----AGAP--------APGPP----------------P :...::..::.::...:.. ..:: :: : : NP_001 --GEAESISSLCSQITNAFSTPEDPFSSAPMTKPVTVVAPQSPTFQANGTDSAFHVLAKP 330 340 350 360 370 390 400 410 pF1KE2 ATTGT------------------------------SAWGEPS-VPPAAAFQPGHKRTPSE : :. . ::. : . . :: ::.::::: NP_001 AHTALAPVAMPVRETNPWAHAPDAANKEIAATCSGTEWGQSSGAASPGLFQAGHRRTPSE 380 390 400 410 420 430 420 430 440 450 460 470 pF1KE2 AERWLEEVSQVAKAQQQQQQQQQQQQQQQQQQAASVAPVPTMPPALQPFPAPVGPFDAAP :.:::::::. ..::: : ::.:: . :.::: : . :.: NP_001 ADRWLEEVSKSVRAQQPQ---------------ASAAP---LQPVLQPPPPTAISQPASP 440 450 460 470 480 480 490 500 510 520 pF1KE2 AQVAVFL---P-P----PHMQPPFVPA--YP-GLGYP-PMPRVPVVGITPSQMVANAFCS : .:: : : : .:: :::: :: . :.: : : ::::::::::::::.: . NP_001 FQGNAFLTSQPVPVGVVPALQPAFVPAQSYPVANGMPYPAPNVPVVGITPSQMVANVFGT 490 500 510 520 530 540 530 540 550 560 570 pF1KE2 AAQLQ---PQPATLLGKAGAFPPPAIPSAPGSQARPRPNGAPWPPEPAPAPAPELDPFEA :.. : :. . : . .:: :: : NP_001 AGHPQAAHPHQSPSLVRQQTFPHYEASSATTSPFFKPPAQHLNGSAAFNGVDDGRLASAD 550 560 570 580 590 600 580 590 600 pF1KE2 QWAALEGKATVEKPSNPFSGDLQKTFEIEL NP_001 RHTEVPTGTCPVDPFEAQWAALENKSKQRTNPSPTNPFSSDLQKTFEIEL 610 620 630 640 650 607 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 05:01:16 2016 done: Sun Nov 6 05:01:18 2016 Total Scan time: 13.290 Total Display time: 0.090 Function used was FASTA [36.3.4 Apr, 2011]