FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE2079, 752 aa 1>>>pF1KE2079 752 - 752 aa - 752 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.7427+/-0.000446; mu= 18.7150+/- 0.028 mean_var=117.5188+/-23.008, 0's: 0 Z-trim(113.4): 329 B-trim: 0 in 0/53 Lambda= 0.118310 statistics sampled from 22354 (22765) to 22354 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.64), E-opt: 0.2 (0.267), width: 16 Scan time: 8.790 The best scores are: opt bits E(85289) NP_000054 (OMIM: 217000,613927,615489) complement ( 752) 5174 895.3 0 NP_001269387 (OMIM: 217000,613927,615489) compleme ( 723) 4561 790.6 0 NP_001139375 (OMIM: 217000,613927,615489) compleme ( 620) 4104 712.6 1.2e-204 NP_001269386 (OMIM: 217000,613927,615489) compleme ( 506) 3171 553.2 9.4e-157 NP_001171534 (OMIM: 217000,613927,615489) compleme ( 538) 2902 507.3 6.5e-143 NP_001269388 (OMIM: 217000,613927,615489) compleme ( 328) 2007 354.3 4.5e-97 NP_001701 (OMIM: 138470,612924,615489,615561) comp ( 764) 1849 327.8 1.1e-88 XP_011533056 (OMIM: 608397) PREDICTED: CUB and sus (2238) 360 74.1 7e-12 XP_011533055 (OMIM: 608397) PREDICTED: CUB and sus (2595) 360 74.2 7.8e-12 XP_016869220 (OMIM: 608397) PREDICTED: CUB and sus (3327) 360 74.3 9.2e-12 XP_011533054 (OMIM: 608397) PREDICTED: CUB and sus (3549) 360 74.3 9.6e-12 NP_150094 (OMIM: 608397) CUB and sushi domain-cont (3564) 360 74.3 9.6e-12 XP_016855679 (OMIM: 608398) PREDICTED: CUB and sus (3362) 341 71.1 8.8e-11 XP_016855678 (OMIM: 608398) PREDICTED: CUB and sus (3506) 341 71.1 9e-11 XP_016855683 (OMIM: 608398) PREDICTED: CUB and sus (3566) 341 71.1 9.1e-11 XP_016855677 (OMIM: 608398) PREDICTED: CUB and sus (3567) 341 71.1 9.1e-11 XP_016855676 (OMIM: 608398) PREDICTED: CUB and sus (3606) 341 71.1 9.2e-11 XP_016855675 (OMIM: 608398) PREDICTED: CUB and sus (3607) 341 71.1 9.2e-11 XP_016855674 (OMIM: 608398) PREDICTED: CUB and sus (3607) 341 71.1 9.2e-11 NP_001268885 (OMIM: 608398) CUB and sushi domain-c (3631) 341 71.1 9.2e-11 XP_011515117 (OMIM: 608399) PREDICTED: CUB and sus (2173) 323 67.8 5.5e-10 XP_016868501 (OMIM: 608399) PREDICTED: CUB and sus (3463) 323 68.0 7.5e-10 XP_016868500 (OMIM: 608399) PREDICTED: CUB and sus (3507) 323 68.0 7.6e-10 NP_443132 (OMIM: 608399) CUB and sushi domain-cont (3538) 323 68.0 7.6e-10 XP_016868499 (OMIM: 608399) PREDICTED: CUB and sus (3577) 323 68.0 7.7e-10 XP_011515118 (OMIM: 608399) PREDICTED: CUB and sus (3603) 323 68.0 7.7e-10 XP_016868498 (OMIM: 608399) PREDICTED: CUB and sus (3637) 323 68.0 7.8e-10 NP_937757 (OMIM: 608399) CUB and sushi domain-cont (3667) 323 68.0 7.8e-10 XP_016868497 (OMIM: 608399) PREDICTED: CUB and sus (3681) 323 68.0 7.8e-10 NP_937756 (OMIM: 608399) CUB and sushi domain-cont (3707) 323 68.0 7.9e-10 NP_443128 (OMIM: 608398) CUB and sushi domain-cont (3487) 313 66.3 2.5e-09 NP_000441 (OMIM: 131210,145500) E-selectin precurs ( 610) 298 62.9 4.5e-09 XP_011528291 (OMIM: 206200,609862) PREDICTED: tran ( 680) 293 62.1 8.7e-09 NP_001275929 (OMIM: 206200,609862) transmembrane p ( 824) 293 62.2 9.9e-09 XP_005245493 (OMIM: 147050,173610) PREDICTED: P-se ( 830) 273 58.8 1.1e-07 XP_005245492 (OMIM: 147050,173610) PREDICTED: P-se ( 830) 273 58.8 1.1e-07 NP_002996 (OMIM: 147050,173610) P-selectin precurs ( 830) 273 58.8 1.1e-07 XP_011507508 (OMIM: 120650,240500,610927,614699) P ( 969) 260 56.7 5.5e-07 NP_000033 (OMIM: 138700) beta-2-glycoprotein 1 pre ( 345) 254 55.2 5.5e-07 NP_001868 (OMIM: 120650,240500,610927,614699) comp (1033) 260 56.7 5.7e-07 NP_001006659 (OMIM: 120650,240500,610927,614699) c (1092) 260 56.7 5.9e-07 XP_005245497 (OMIM: 147050,173610) PREDICTED: P-se ( 768) 246 54.2 2.4e-06 NP_000564 (OMIM: 120620,607486,611162) complement (2039) 247 54.8 4.2e-06 XP_006711229 (OMIM: 120620,607486,611162) PREDICTE (2459) 247 54.9 4.8e-06 NP_000642 (OMIM: 120620,607486,611162) complement (2489) 247 54.9 4.8e-06 XP_011507507 (OMIM: 120620,607486,611162) PREDICTE (2554) 247 54.9 4.9e-06 NP_699197 (OMIM: 611691) sushi, von Willebrand fac (3571) 246 54.9 7e-06 XP_016882221 (OMIM: 142440) PREDICTED: serine prot ( 393) 232 51.5 8.1e-06 XP_005258895 (OMIM: 142440) PREDICTED: serine prot ( 417) 232 51.5 8.5e-06 NP_002142 (OMIM: 142440) serine protease hepsin pr ( 417) 232 51.5 8.5e-06 >>NP_000054 (OMIM: 217000,613927,615489) complement C2 i (752 aa) initn: 5174 init1: 5174 opt: 5174 Z-score: 4780.7 bits: 895.3 E(85289): 0 Smith-Waterman score: 5174; 100.0% identity (100.0% similar) in 752 aa overlap (1-752:1-752) 10 20 30 40 50 60 pF1KE2 MGPLMVLFCLLFLYPGLADSAPSCPQNVNISGGTFTLSHGWAPGSLLTYSCPQGLYPSPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 MGPLMVLFCLLFLYPGLADSAPSCPQNVNISGGTFTLSHGWAPGSLLTYSCPQGLYPSPA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 SRLCKSSGQWQTPGATRSLSKAVCKPVRCPAPVSFENGIYTPRLGSYPVGGNVSFECEDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 SRLCKSSGQWQTPGATRSLSKAVCKPVRCPAPVSFENGIYTPRLGSYPVGGNVSFECEDG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 FILRGSPVRQCRPNGMWDGETAVCDNGAGHCPNPGISLGAVRTGFRFGHGDKVRYRCSSN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 FILRGSPVRQCRPNGMWDGETAVCDNGAGHCPNPGISLGAVRTGFRFGHGDKVRYRCSSN 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 LVLTGSSERECQGNGVWSGTEPICRQPYSYDFPEDVAPALGTSFSHMLGATNPTQKTKES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 LVLTGSSERECQGNGVWSGTEPICRQPYSYDFPEDVAPALGTSFSHMLGATNPTQKTKES 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 LGRKIQIQRSGHLNLYLLLDCSQSVSENDFLIFKESASLMVDRIFSFEINVSVAIITFAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 LGRKIQIQRSGHLNLYLLLDCSQSVSENDFLIFKESASLMVDRIFSFEINVSVAIITFAS 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 EPKVLMSVLNDNSRDMTEVISSLENANYKDHENGTGTNTYAALNSVYLMMNNQMRLLGME :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 EPKVLMSVLNDNSRDMTEVISSLENANYKDHENGTGTNTYAALNSVYLMMNNQMRLLGME 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 TMAWQEIRHAIILLTDGKSNMGGSPKTAVDHIREILNINQKRNDYLDIYAIGVGKLDVDW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 TMAWQEIRHAIILLTDGKSNMGGSPKTAVDHIREILNINQKRNDYLDIYAIGVGKLDVDW 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE2 RELNELGSKKDGERHAFILQDTKALHQVFEHMLDVSKLTDTICGVGNMSANASDQERTPW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 RELNELGSKKDGERHAFILQDTKALHQVFEHMLDVSKLTDTICGVGNMSANASDQERTPW 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE2 HVTIKPKSQETCRGALISDQWVLTAAHCFRDGNDHSLWRVNVGDPKSQWGKEFLIEKAVI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 HVTIKPKSQETCRGALISDQWVLTAAHCFRDGNDHSLWRVNVGDPKSQWGKEFLIEKAVI 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE2 SPGFDVFAKKNQGILEFYGDDIALLKLAQKVKMSTHARPICLPCTMEANLALRRPQGSTC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 SPGFDVFAKKNQGILEFYGDDIALLKLAQKVKMSTHARPICLPCTMEANLALRRPQGSTC 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE2 RDHENELLNKQSVPAHFVALNGSKLNINLKMGVEWTSCAEVVSQEKTMFPNLTDVREVVT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 RDHENELLNKQSVPAHFVALNGSKLNINLKMGVEWTSCAEVVSQEKTMFPNLTDVREVVT 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE2 DQFLCSGTQEDESPCKGESGGAVFLERRFRFFQVGLVSWGLYNPCLGSADKNSRKRAPRS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 DQFLCSGTQEDESPCKGESGGAVFLERRFRFFQVGLVSWGLYNPCLGSADKNSRKRAPRS 670 680 690 700 710 720 730 740 750 pF1KE2 KVPPPRDFHINLFRMQPWLRQHLGDVLNFLPL :::::::::::::::::::::::::::::::: NP_000 KVPPPRDFHINLFRMQPWLRQHLGDVLNFLPL 730 740 750 >>NP_001269387 (OMIM: 217000,613927,615489) complement C (723 aa) initn: 4559 init1: 4559 opt: 4561 Z-score: 4215.5 bits: 790.6 E(85289): 0 Smith-Waterman score: 4572; 94.8% identity (95.8% similar) in 714 aa overlap (57-752:10-723) 30 40 50 60 70 pF1KE2 NVNISGGTFTLSHGWAPGSLLTYSCPQGLYPSPASRLCK-----------SSGQWQTP-- :.:: : : .::. : : NP_001 MAGLLGAFSPTPAPRACTHPQHHGCARAADSGRPQEPPG 10 20 30 80 90 100 110 120 pF1KE2 -----GATRSLSKAVCKPVRCPAPVSFENGIYTPRLGSYPVGGNVSFECEDGFILRGSPV .:. : . . :::::::::::::::::::::::::::::::::::::::::: NP_001 LCLRRSANVRLPVGFAQAVRCPAPVSFENGIYTPRLGSYPVGGNVSFECEDGFILRGSPV 40 50 60 70 80 90 130 140 150 160 170 180 pF1KE2 RQCRPNGMWDGETAVCDNGAGHCPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLTGSSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RQCRPNGMWDGETAVCDNGAGHCPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLTGSSE 100 110 120 130 140 150 190 200 210 220 230 240 pF1KE2 RECQGNGVWSGTEPICRQPYSYDFPEDVAPALGTSFSHMLGATNPTQKTKESLGRKIQIQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RECQGNGVWSGTEPICRQPYSYDFPEDVAPALGTSFSHMLGATNPTQKTKESLGRKIQIQ 160 170 180 190 200 210 250 260 270 280 290 300 pF1KE2 RSGHLNLYLLLDCSQSVSENDFLIFKESASLMVDRIFSFEINVSVAIITFASEPKVLMSV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RSGHLNLYLLLDCSQSVSENDFLIFKESASLMVDRIFSFEINVSVAIITFASEPKVLMSV 220 230 240 250 260 270 310 320 330 340 350 360 pF1KE2 LNDNSRDMTEVISSLENANYKDHENGTGTNTYAALNSVYLMMNNQMRLLGMETMAWQEIR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LNDNSRDMTEVISSLENANYKDHENGTGTNTYAALNSVYLMMNNQMRLLGMETMAWQEIR 280 290 300 310 320 330 370 380 390 400 410 420 pF1KE2 HAIILLTDGKSNMGGSPKTAVDHIREILNINQKRNDYLDIYAIGVGKLDVDWRELNELGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HAIILLTDGKSNMGGSPKTAVDHIREILNINQKRNDYLDIYAIGVGKLDVDWRELNELGS 340 350 360 370 380 390 430 440 450 460 470 480 pF1KE2 KKDGERHAFILQDTKALHQVFEHMLDVSKLTDTICGVGNMSANASDQERTPWHVTIKPKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KKDGERHAFILQDTKALHQVFEHMLDVSKLTDTICGVGNMSANASDQERTPWHVTIKPKS 400 410 420 430 440 450 490 500 510 520 530 540 pF1KE2 QETCRGALISDQWVLTAAHCFRDGNDHSLWRVNVGDPKSQWGKEFLIEKAVISPGFDVFA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QETCRGALISDQWVLTAAHCFRDGNDHSLWRVNVGDPKSQWGKEFLIEKAVISPGFDVFA 460 470 480 490 500 510 550 560 570 580 590 600 pF1KE2 KKNQGILEFYGDDIALLKLAQKVKMSTHARPICLPCTMEANLALRRPQGSTCRDHENELL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KKNQGILEFYGDDIALLKLAQKVKMSTHARPICLPCTMEANLALRRPQGSTCRDHENELL 520 530 540 550 560 570 610 620 630 640 650 660 pF1KE2 NKQSVPAHFVALNGSKLNINLKMGVEWTSCAEVVSQEKTMFPNLTDVREVVTDQFLCSGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NKQSVPAHFVALNGSKLNINLKMGVEWTSCAEVVSQEKTMFPNLTDVREVVTDQFLCSGT 580 590 600 610 620 630 670 680 690 700 710 720 pF1KE2 QEDESPCKGESGGAVFLERRFRFFQVGLVSWGLYNPCLGSADKNSRKRAPRSKVPPPRDF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QEDESPCKGESGGAVFLERRFRFFQVGLVSWGLYNPCLGSADKNSRKRAPRSKVPPPRDF 640 650 660 670 680 690 730 740 750 pF1KE2 HINLFRMQPWLRQHLGDVLNFLPL :::::::::::::::::::::::: NP_001 HINLFRMQPWLRQHLGDVLNFLPL 700 710 720 >>NP_001139375 (OMIM: 217000,613927,615489) complement C (620 aa) initn: 4199 init1: 4104 opt: 4104 Z-score: 3794.7 bits: 712.6 E(85289): 1.2e-204 Smith-Waterman score: 4104; 100.0% identity (100.0% similar) in 605 aa overlap (148-752:16-620) 120 130 140 150 160 170 pF1KE2 EDGFILRGSPVRQCRPNGMWDGETAVCDNGAGHCPNPGISLGAVRTGFRFGHGDKVRYRC :::::::::::::::::::::::::::::: NP_001 MGPLMVLFCLLFLYPAGHCPNPGISLGAVRTGFRFGHGDKVRYRC 10 20 30 40 180 190 200 210 220 230 pF1KE2 SSNLVLTGSSERECQGNGVWSGTEPICRQPYSYDFPEDVAPALGTSFSHMLGATNPTQKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SSNLVLTGSSERECQGNGVWSGTEPICRQPYSYDFPEDVAPALGTSFSHMLGATNPTQKT 50 60 70 80 90 100 240 250 260 270 280 290 pF1KE2 KESLGRKIQIQRSGHLNLYLLLDCSQSVSENDFLIFKESASLMVDRIFSFEINVSVAIIT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KESLGRKIQIQRSGHLNLYLLLDCSQSVSENDFLIFKESASLMVDRIFSFEINVSVAIIT 110 120 130 140 150 160 300 310 320 330 340 350 pF1KE2 FASEPKVLMSVLNDNSRDMTEVISSLENANYKDHENGTGTNTYAALNSVYLMMNNQMRLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FASEPKVLMSVLNDNSRDMTEVISSLENANYKDHENGTGTNTYAALNSVYLMMNNQMRLL 170 180 190 200 210 220 360 370 380 390 400 410 pF1KE2 GMETMAWQEIRHAIILLTDGKSNMGGSPKTAVDHIREILNINQKRNDYLDIYAIGVGKLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GMETMAWQEIRHAIILLTDGKSNMGGSPKTAVDHIREILNINQKRNDYLDIYAIGVGKLD 230 240 250 260 270 280 420 430 440 450 460 470 pF1KE2 VDWRELNELGSKKDGERHAFILQDTKALHQVFEHMLDVSKLTDTICGVGNMSANASDQER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VDWRELNELGSKKDGERHAFILQDTKALHQVFEHMLDVSKLTDTICGVGNMSANASDQER 290 300 310 320 330 340 480 490 500 510 520 530 pF1KE2 TPWHVTIKPKSQETCRGALISDQWVLTAAHCFRDGNDHSLWRVNVGDPKSQWGKEFLIEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TPWHVTIKPKSQETCRGALISDQWVLTAAHCFRDGNDHSLWRVNVGDPKSQWGKEFLIEK 350 360 370 380 390 400 540 550 560 570 580 590 pF1KE2 AVISPGFDVFAKKNQGILEFYGDDIALLKLAQKVKMSTHARPICLPCTMEANLALRRPQG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AVISPGFDVFAKKNQGILEFYGDDIALLKLAQKVKMSTHARPICLPCTMEANLALRRPQG 410 420 430 440 450 460 600 610 620 630 640 650 pF1KE2 STCRDHENELLNKQSVPAHFVALNGSKLNINLKMGVEWTSCAEVVSQEKTMFPNLTDVRE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 STCRDHENELLNKQSVPAHFVALNGSKLNINLKMGVEWTSCAEVVSQEKTMFPNLTDVRE 470 480 490 500 510 520 660 670 680 690 700 710 pF1KE2 VVTDQFLCSGTQEDESPCKGESGGAVFLERRFRFFQVGLVSWGLYNPCLGSADKNSRKRA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VVTDQFLCSGTQEDESPCKGESGGAVFLERRFRFFQVGLVSWGLYNPCLGSADKNSRKRA 530 540 550 560 570 580 720 730 740 750 pF1KE2 PRSKVPPPRDFHINLFRMQPWLRQHLGDVLNFLPL ::::::::::::::::::::::::::::::::::: NP_001 PRSKVPPPRDFHINLFRMQPWLRQHLGDVLNFLPL 590 600 610 620 >>NP_001269386 (OMIM: 217000,613927,615489) complement C (506 aa) initn: 3171 init1: 3171 opt: 3171 Z-score: 2935.2 bits: 553.2 E(85289): 9.4e-157 Smith-Waterman score: 3171; 100.0% identity (100.0% similar) in 469 aa overlap (284-752:38-506) 260 270 280 290 300 310 pF1KE2 NLYLLLDCSQSVSENDFLIFKESASLMVDRIFSFEINVSVAIITFASEPKVLMSVLNDNS :::::::::::::::::::::::::::::: NP_001 AAPRILCSRGLRSGSARATGSGVERSPSAAIFSFEINVSVAIITFASEPKVLMSVLNDNS 10 20 30 40 50 60 320 330 340 350 360 370 pF1KE2 RDMTEVISSLENANYKDHENGTGTNTYAALNSVYLMMNNQMRLLGMETMAWQEIRHAIIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RDMTEVISSLENANYKDHENGTGTNTYAALNSVYLMMNNQMRLLGMETMAWQEIRHAIIL 70 80 90 100 110 120 380 390 400 410 420 430 pF1KE2 LTDGKSNMGGSPKTAVDHIREILNINQKRNDYLDIYAIGVGKLDVDWRELNELGSKKDGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LTDGKSNMGGSPKTAVDHIREILNINQKRNDYLDIYAIGVGKLDVDWRELNELGSKKDGE 130 140 150 160 170 180 440 450 460 470 480 490 pF1KE2 RHAFILQDTKALHQVFEHMLDVSKLTDTICGVGNMSANASDQERTPWHVTIKPKSQETCR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RHAFILQDTKALHQVFEHMLDVSKLTDTICGVGNMSANASDQERTPWHVTIKPKSQETCR 190 200 210 220 230 240 500 510 520 530 540 550 pF1KE2 GALISDQWVLTAAHCFRDGNDHSLWRVNVGDPKSQWGKEFLIEKAVISPGFDVFAKKNQG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GALISDQWVLTAAHCFRDGNDHSLWRVNVGDPKSQWGKEFLIEKAVISPGFDVFAKKNQG 250 260 270 280 290 300 560 570 580 590 600 610 pF1KE2 ILEFYGDDIALLKLAQKVKMSTHARPICLPCTMEANLALRRPQGSTCRDHENELLNKQSV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ILEFYGDDIALLKLAQKVKMSTHARPICLPCTMEANLALRRPQGSTCRDHENELLNKQSV 310 320 330 340 350 360 620 630 640 650 660 670 pF1KE2 PAHFVALNGSKLNINLKMGVEWTSCAEVVSQEKTMFPNLTDVREVVTDQFLCSGTQEDES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PAHFVALNGSKLNINLKMGVEWTSCAEVVSQEKTMFPNLTDVREVVTDQFLCSGTQEDES 370 380 390 400 410 420 680 690 700 710 720 730 pF1KE2 PCKGESGGAVFLERRFRFFQVGLVSWGLYNPCLGSADKNSRKRAPRSKVPPPRDFHINLF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PCKGESGGAVFLERRFRFFQVGLVSWGLYNPCLGSADKNSRKRAPRSKVPPPRDFHINLF 430 440 450 460 470 480 740 750 pF1KE2 RMQPWLRQHLGDVLNFLPL ::::::::::::::::::: NP_001 RMQPWLRQHLGDVLNFLPL 490 500 >>NP_001171534 (OMIM: 217000,613927,615489) complement C (538 aa) initn: 2902 init1: 2902 opt: 2902 Z-score: 2686.7 bits: 507.3 E(85289): 6.5e-143 Smith-Waterman score: 3352; 85.0% identity (85.0% similar) in 605 aa overlap (148-752:25-538) 120 130 140 150 160 170 pF1KE2 EDGFILRGSPVRQCRPNGMWDGETAVCDNGAGHCPNPGISLGAVRTGFRFGHGDKVRYRC :::::::::::::::::::::::::::::: NP_001 MRALCIRETCSSELGFSRNWSRRKAGHCPNPGISLGAVRTGFRFGHGDKVRYRC 10 20 30 40 50 180 190 200 210 220 230 pF1KE2 SSNLVLTGSSERECQGNGVWSGTEPICRQPYSYDFPEDVAPALGTSFSHMLGATNPTQKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SSNLVLTGSSERECQGNGVWSGTEPICRQPYSYDFPEDVAPALGTSFSHMLGATNPTQKT 60 70 80 90 100 110 240 250 260 270 280 290 pF1KE2 KESLGRKIQIQRSGHLNLYLLLDCSQSVSENDFLIFKESASLMVDRIFSFEINVSVAIIT : NP_001 K----------------------------------------------------------- 300 310 320 330 340 350 pF1KE2 FASEPKVLMSVLNDNSRDMTEVISSLENANYKDHENGTGTNTYAALNSVYLMMNNQMRLL :::::::::::::::::::::::::::: NP_001 --------------------------------DHENGTGTNTYAALNSVYLMMNNQMRLL 120 130 140 360 370 380 390 400 410 pF1KE2 GMETMAWQEIRHAIILLTDGKSNMGGSPKTAVDHIREILNINQKRNDYLDIYAIGVGKLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GMETMAWQEIRHAIILLTDGKSNMGGSPKTAVDHIREILNINQKRNDYLDIYAIGVGKLD 150 160 170 180 190 200 420 430 440 450 460 470 pF1KE2 VDWRELNELGSKKDGERHAFILQDTKALHQVFEHMLDVSKLTDTICGVGNMSANASDQER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VDWRELNELGSKKDGERHAFILQDTKALHQVFEHMLDVSKLTDTICGVGNMSANASDQER 210 220 230 240 250 260 480 490 500 510 520 530 pF1KE2 TPWHVTIKPKSQETCRGALISDQWVLTAAHCFRDGNDHSLWRVNVGDPKSQWGKEFLIEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TPWHVTIKPKSQETCRGALISDQWVLTAAHCFRDGNDHSLWRVNVGDPKSQWGKEFLIEK 270 280 290 300 310 320 540 550 560 570 580 590 pF1KE2 AVISPGFDVFAKKNQGILEFYGDDIALLKLAQKVKMSTHARPICLPCTMEANLALRRPQG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AVISPGFDVFAKKNQGILEFYGDDIALLKLAQKVKMSTHARPICLPCTMEANLALRRPQG 330 340 350 360 370 380 600 610 620 630 640 650 pF1KE2 STCRDHENELLNKQSVPAHFVALNGSKLNINLKMGVEWTSCAEVVSQEKTMFPNLTDVRE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 STCRDHENELLNKQSVPAHFVALNGSKLNINLKMGVEWTSCAEVVSQEKTMFPNLTDVRE 390 400 410 420 430 440 660 670 680 690 700 710 pF1KE2 VVTDQFLCSGTQEDESPCKGESGGAVFLERRFRFFQVGLVSWGLYNPCLGSADKNSRKRA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VVTDQFLCSGTQEDESPCKGESGGAVFLERRFRFFQVGLVSWGLYNPCLGSADKNSRKRA 450 460 470 480 490 500 720 730 740 750 pF1KE2 PRSKVPPPRDFHINLFRMQPWLRQHLGDVLNFLPL ::::::::::::::::::::::::::::::::::: NP_001 PRSKVPPPRDFHINLFRMQPWLRQHLGDVLNFLPL 510 520 530 >>NP_001269388 (OMIM: 217000,613927,615489) complement C (328 aa) initn: 2007 init1: 2007 opt: 2007 Z-score: 1863.7 bits: 354.3 E(85289): 4.5e-97 Smith-Waterman score: 2009; 88.4% identity (93.3% similar) in 328 aa overlap (1-316:1-328) 10 20 30 40 50 60 pF1KE2 MGPLMVLFCLLFLYPGLADSAPSCPQNVNISGGTFTLSHGWAPGSLLTYSCPQGLYPSPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MGPLMVLFCLLFLYPGLADSAPSCPQNVNISGGTFTLSHGWAPGSLLTYSCPQGLYPSPA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 SRLCKSSGQWQTPGATRSLSKAVCKPVRCPAPVSFENGIYTPRLGSYPVGGNVSFECEDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SRLCKSSGQWQTPGATRSLSKAVCKPVRCPAPVSFENGIYTPRLGSYPVGGNVSFECEDG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 FILRGSPVRQCRPNGMWDGETAVCDNGAGHCPNPGISLGAVRTGFRFGHGDKVRYRCSSN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FILRGSPVRQCRPNGMWDGETAVCDNGAGHCPNPGISLGAVRTGFRFGHGDKVRYRCSSN 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 LVLTGSSERECQGNGVWSGTEPICRQPYSYDFPEDVAPALGTSFSHMLGATNPTQKTKES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LVLTGSSERECQGNGVWSGTEPICRQPYSYDFPEDVAPALGTSFSHMLGATNPTQKTKES 190 200 210 220 230 240 250 260 270 280 290 pF1KE2 LGRKIQIQRSGHLNLYLLLDCSQSVSENDFLIFKESASLMVDRIFSFE---------INV :::::::::::::::::::::::::::::::::::::::::::. . : ... NP_001 LGRKIQIQRSGHLNLYLLLDCSQSVSENDFLIFKESASLMVDRVRNQESACSRGLPVLTI 250 260 270 280 290 300 300 310 320 330 340 pF1KE2 SVAIITFASEP---KVLMSVLNDNSRDMTEVISSLENANYKDHENGTGTNTYAALNSVYL :. .. . : ..:. :..: .. : NP_001 SLCLLPLLRTPLTAHLLQEVFSDYTHAM 310 320 >>NP_001701 (OMIM: 138470,612924,615489,615561) compleme (764 aa) initn: 1524 init1: 548 opt: 1849 Z-score: 1713.5 bits: 327.8 E(85289): 1.1e-88 Smith-Waterman score: 1849; 39.8% identity (69.6% similar) in 757 aa overlap (17-750:30-764) 10 20 30 40 pF1KE2 MGPLMVLFCLLFLYPGLADSAPSCP-QNVNISGGTFTLSHGWAPGSL :: :: ..:.:.::.: : . :. NP_001 MGSNLSPQLCLMPFILGLLSGGVTTTPWSLARPQGSCSLEGVEIKGGSFRLLQ---EGQA 10 20 30 40 50 50 60 70 80 90 100 pF1KE2 LTYSCPQGLYPSPA-SRLCKSSGQWQT--PGATRSLSKAVCKPVRCPAPVSFENGIYTPR : : ::.:.:: :. .: :.:.:.:.: ... :: :. ..:: : .:::: : :: NP_001 LEYVCPSGFYPYPVQTRTCRSTGSWSTLKTQDQKTVRKAECRAIHCPRPHDFENGEYWPR 60 70 80 90 100 110 110 120 130 140 150 160 pF1KE2 LGSYPVGGNVSFECEDGFILRGSPVRQCRPNGMWDGETAVCDNGAGHCPNPGISLGAVRT : :. ..::.: ::. :::: : :. :: :.:.::.::::::.: :::: .:. .. NP_001 SPYYNVSDEISFHCYDGYTLRGSANRTCQVNGRWSGQTAICDNGAGYCSNPGIPIGTRKV 120 130 140 150 160 170 170 180 190 200 210 220 pF1KE2 GFRFGHGDKVRYRCSSNLVLTGSSERECQGNGVWSGTEPICRQPYSYDFPEDVAPALGTS : .. :.: :.:: .:.: ::..: :: .: :::::: :.. . :: :..:: :. .: NP_001 GSQYRLEDSVTYHCSRGLTLRGSQRRTCQEGGSWSGTEPSCQDSFMYDTPQEVAEAFLSS 180 190 200 210 220 230 230 240 250 260 270 280 pF1KE2 FSHMLGATNPT--QKTKESLGRKIQIQRSGHLNLYLLLDCSQSVSENDFLIFKESASLMV ... . ... . :. ::: .. :: .:.::.:: :.:.. ..: :. .. NP_001 LTETIEGVDAEDGHGPGEQQKRKIVLDPSGSMNIYLVLDGSDSIGASNFTGAKKCLVNLI 240 250 260 270 280 290 290 300 310 320 330 340 pF1KE2 DRIFSFEINVSVAIITFASEPKVLMSVLNDNSRDMTEVISSLENANYKDHENGTGTNTYA ... :. .. ...:.:. ::. ..: . .: . : ..:.. ::.::. .:::: NP_001 EKVASYGVKPRYGLVTYATYPKIWVKVSEADSSNADWVTKQLNEINYEDHKLKSGTNTKK 300 310 320 330 340 350 350 360 370 380 390 400 pF1KE2 ALNSVYLMMNNQMRLLGMETMAWQEIRHAIILLTDGKSNMGGSPKTAVDHIREILNINQK ::..:: ::. . .:.. ::.:::.::: ::::.: :..:.::..: :.. NP_001 ALQAVYSMMSWPD---DVPPEGWNRTRHVIILMTDGLHNMGGDPITVIDEIRDLLYIGKD 360 370 380 390 400 410 410 420 430 440 450 pF1KE2 RN----DYLDIYAIGVGKLDVDWRELNELGSKKDGERHAFILQDTKALHQVFEHMLDVSK :. ::::.:..::: : :. ..: :.::::.:.:.: ..: . :..:: .:.: :. NP_001 RKNPREDYLDVYVFGVGPL-VNQVNINALASKKDNEQHVFKVKDMENLEDVFYQMIDESQ 420 430 440 450 460 470 460 470 480 490 500 510 pF1KE2 LTDTICGVGNMSANASDQERTPWHV---TIKP-KSQETCRGALISDQWVLTAAHCFR-DG . ..::. ...: .. ::.. .:.: :..:.: ::..:. .:::::::: : NP_001 -SLSLCGMVWEHRKGTDYHKQPWQAKISVIRPSKGHESCMGAVVSEYFVLTAAHCFTVDD 480 490 500 510 520 530 520 530 540 550 560 570 pF1KE2 NDHSLWRVNVGDPKSQWGKEFLIEKAVISPGFDVFAKKNQGILEFYGDDIALLKLAQKVK ..::. .:.:: : ... :: ... :.... .::. :: ::: :.::.:: .:.: NP_001 KEHSI-KVSVGGEK----RDLEIEVVLFHPNYNINGKKEAGIPEFYDYDVALIKLKNKLK 540 550 560 570 580 580 590 600 610 620 pF1KE2 MSTHARPICLPCTMEANLALRRPQGSTCRDHENELLNKQSVPAHFVALNGSKLN---INL .. :::::::: .. ::: : .::.....::: :.. : ::. . .::. . . NP_001 YGQTIRPICLPCTEGTTRALRLPPTTTCQQQKEELLPAQDIKALFVSEEEKKLTRKEVYI 590 600 610 620 630 640 630 640 650 660 670 680 pF1KE2 KMGVEWTSCAEVVSQEKTMFPNLTDVREVVTDQFLCSG---TQEDESPCKGESGGAVFLE : : . :: : .: . .. :. :::: .:::.: : . :.:.::: .... NP_001 KNGDKKGSC-ERDAQYAPGYDKVKDISEVVTPRFLCTGGVSPYADPNTCRGDSGGPLIVH 650 660 670 680 690 700 690 700 710 720 730 740 pF1KE2 RRFRFFQVGLVSWGLYNPCLGSADKNSRKRAPRSKVPP-PRDFHINLFRMQPWLRQHLGD .: ::.:::..:::. . : ::... ...:: ::::::::.. :::...: : NP_001 KRSRFIQVGVISWGVVDVC-----KNQKR---QKQVPAHARDFHINLFQVLPWLKEKLQD 710 720 730 740 750 750 pF1KE2 V-LNFLPL :.:: NP_001 EDLGFL 760 >>XP_011533056 (OMIM: 608397) PREDICTED: CUB and sushi d (2238 aa) initn: 352 init1: 194 opt: 360 Z-score: 334.3 bits: 74.1 E(85289): 7e-12 Smith-Waterman score: 380; 31.7% identity (56.2% similar) in 224 aa overlap (20-231:1702-1912) 10 20 30 40 pF1KE2 MGPLMVLFCLLFLYPGLADSAPSCPQNVNISGGTFTLSHGWAPGSLLT- .::.: .. : ::..: :. .: XP_011 SSSVIYACWEGYKTSGLMTRHCTANGTWTGTAPDC--TIISCGDPGTLANGIQFGTDFTF 1680 1690 1700 1710 1720 50 60 70 80 90 100 pF1KE2 -----YSCPQGLYP---SPASRLCKSSGQWQTPGATRSLSKAVCKPVRCPAPVSFENGIY :.: : . :. : ..:.:. : :: ::: : :: : .:: XP_011 NKTVSYQCNPGYVMEAVTSATIRCTKDGRWN-P------SKPVCKAVLCPQPPPVQNG-- 1730 1740 1750 1760 1770 1780 110 120 130 140 150 160 pF1KE2 TPRLGSYPVGGNVSFECEDGFILRGSPVRQCRPNGMWDGETAVCDNGAGHCPNPGISLGA : . ... :...:. : ::. : : . .:. :.: :: : : .::: . XP_011 TVEGSDFRWGSSISYSCMDGYQLSHSAILSCEGRGVWKGEIPQCL--PVFCGDPGIPAEG 1790 1800 1810 1820 1830 170 180 190 200 210 220 pF1KE2 VRTGFRFGHGDKVRYRCSSNLVLTGSSERECQGNGVWSGTEPICRQPYSYDFPEDVAPAL .: : . ..: ..:.: ..:.:::.: ::..:.::: .: : .: :. .: . XP_011 RLSGKSFTYKSEVFFQCKSPFILVGSSRRVCQADGTWSGIQPTCIDPAHNTCPDPGTPHF 1840 1850 1860 1870 1880 1890 230 240 250 260 270 pF1KE2 G---TSFSHMLGATNPTQKTKESLGRKIQIQRSGHLNLYLLLDCSQSVSENDFLIFKESA : .: .. .:.: XP_011 GIQNSSRGYEVGSTVFFRCRKGYHIQGSTTRTCLANLTWSGIQTECIPHACRQPETPAHA 1900 1910 1920 1930 1940 1950 >-- initn: 341 init1: 151 opt: 335 Z-score: 311.2 bits: 69.8 E(85289): 1.4e-10 Smith-Waterman score: 335; 32.5% identity (53.6% similar) in 194 aa overlap (22-204:1405-1586) 10 20 30 40 pF1KE2 MGPLMVLFCLLFLYPGLADSAPSC-PQNVNISGGTFTLSHGWAPGS----- : : : . . :. .::.. :: XP_011 TVVYQCNPGFRLVGTSVRICLQDHKWSGQTPVCVPITCGHPGNP---AHGFTNGSEFNLN 1380 1390 1400 1410 1420 1430 50 60 70 80 90 100 pF1KE2 -LLTYSCPQGLYPSPASRL-CKSSGQWQTPGATRSLSKAVCKPVRCPAPVSFENGIYTPR .....: : . .:: :.:.:::..: : :. : : : ::.: . XP_011 DVVNFTCNTGYLLQGVSRAQCRSNGQWSSPLPT-------CRVVNCSDPGFVENAIRHGQ 1440 1450 1460 1470 1480 110 120 130 140 150 160 pF1KE2 LG---SYPVGGNVSFECEDGFILRGSPVRQCRPNGMWDGETAVCDNGAGHCPNPGISLGA . :. : .. ..:. :: : :: . : ::.:: : : : .::. .: XP_011 QNFPESFEYGMSILYHCKKGFYLLGSSALTCMANGLWDRSLPKC--LAISCGHPGVPANA 1490 1500 1510 1520 1530 1540 170 180 190 200 210 220 pF1KE2 VRTGFRFGHGDKVRYRCSSNLVLTGSSERECQGNGVWSGTEPICRQPYSYDFPEDVAPAL : :: : .: :.: : .. : :.. : :: .. :::. : : XP_011 VLTGELFTYGAVVHYSCRGSESLIGNDTRVCQEDSHWSGALPHCTGNNPGFCGDPGTPAH 1550 1560 1570 1580 1590 1600 230 240 250 260 270 280 pF1KE2 GTSFSHMLGATNPTQKTKESLGRKIQIQRSGHLNLYLLLDCSQSVSENDFLIFKESASLM XP_011 GSRLGDDFKTKSLLRFSCEMGHQLRGSPERTCLLNGSWSGLQPVCEAVSCGNPGTPTNGM 1610 1620 1630 1640 1650 1660 >-- initn: 220 init1: 144 opt: 278 Z-score: 258.6 bits: 60.1 E(85289): 1.1e-07 Smith-Waterman score: 278; 33.3% identity (55.3% similar) in 159 aa overlap (44-199:1255-1402) 20 30 40 50 60 70 pF1KE2 YPGLADSAPSCPQNVNISGGTFTLSHGWAPGSLLTYSCPQGLYPSPASRL-CKSSGQWQT :. . :: : : : :...: :. XP_011 TCKPVACPSIEAQLSEHVIWRLVSGSLNEYGAQVLLSCSPGYYLEGWRLLRCQANGTWNI 1230 1240 1250 1260 1270 1280 80 90 100 110 120 130 pF1KE2 PGATRSLSKAVCKPVRCPAPVSFE-NGIYTPRLGSYPVGGNVS-FECEDGFILRGSPVRQ : : :. . : . .:: :: ..:. : : .. : :. :. : :: ::. XP_011 -GDERP----SCRVISCGS-LSFPPNG---NKIGTLTVYGATAIFTCNTGYTLVGSHVRE 1290 1300 1310 1320 1330 140 150 160 170 180 190 pF1KE2 CRPNGMWDGETAVCDNGAGHCPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLTGSSERE : ::.:.: . : :::: .: ... .: :.. : : :.:. .. :.:.: : XP_011 CLANGLWSGSETRCL--AGHCGSPDPIVNGHISGDGFSYRDTVVYQCNPGFRLVGTSVRI 1340 1350 1360 1370 1380 1390 200 210 220 230 240 250 pF1KE2 CQGNGVWSGTEPICRQPYSYDFPEDVAPALGTSFSHMLGATNPTQKTKESLGRKIQIQRS : . ::: XP_011 CLQDHKWSGQTPVCVPITCGHPGNPAHGFTNGSEFNLNDVVNFTCNTGYLLQGVSRAQCR 1400 1410 1420 1430 1440 1450 >>XP_011533055 (OMIM: 608397) PREDICTED: CUB and sushi d (2595 aa) initn: 439 init1: 165 opt: 360 Z-score: 333.5 bits: 74.2 E(85289): 7.8e-12 Smith-Waterman score: 380; 31.7% identity (56.2% similar) in 224 aa overlap (20-231:2059-2269) 10 20 30 40 pF1KE2 MGPLMVLFCLLFLYPGLADSAPSCPQNVNISGGTFTLSHGWAPGSLLT- .::.: .. : ::..: :. .: XP_011 SSSVIYACWEGYKTSGLMTRHCTANGTWTGTAPDC--TIISCGDPGTLANGIQFGTDFTF 2030 2040 2050 2060 2070 2080 50 60 70 80 90 100 pF1KE2 -----YSCPQGLYP---SPASRLCKSSGQWQTPGATRSLSKAVCKPVRCPAPVSFENGIY :.: : . :. : ..:.:. : :: ::: : :: : .:: XP_011 NKTVSYQCNPGYVMEAVTSATIRCTKDGRWN-P------SKPVCKAVLCPQPPPVQNG-- 2090 2100 2110 2120 2130 110 120 130 140 150 160 pF1KE2 TPRLGSYPVGGNVSFECEDGFILRGSPVRQCRPNGMWDGETAVCDNGAGHCPNPGISLGA : . ... :...:. : ::. : : . .:. :.: :: : : .::: . XP_011 TVEGSDFRWGSSISYSCMDGYQLSHSAILSCEGRGVWKGEIPQCL--PVFCGDPGIPAEG 2140 2150 2160 2170 2180 2190 170 180 190 200 210 220 pF1KE2 VRTGFRFGHGDKVRYRCSSNLVLTGSSERECQGNGVWSGTEPICRQPYSYDFPEDVAPAL .: : . ..: ..:.: ..:.:::.: ::..:.::: .: : .: :. .: . XP_011 RLSGKSFTYKSEVFFQCKSPFILVGSSRRVCQADGTWSGIQPTCIDPAHNTCPDPGTPHF 2200 2210 2220 2230 2240 2250 230 240 250 260 270 pF1KE2 G---TSFSHMLGATNPTQKTKESLGRKIQIQRSGHLNLYLLLDCSQSVSENDFLIFKESA : .: .. .:.: XP_011 GIQNSSRGYEVGSTVFFRCRKGYHIQGSTTRTCLANLTWSGIQTECIPHACRQPETPAHA 2260 2270 2280 2290 2300 2310 >-- initn: 288 init1: 151 opt: 335 Z-score: 310.4 bits: 69.9 E(85289): 1.5e-10 Smith-Waterman score: 335; 32.5% identity (53.6% similar) in 194 aa overlap (22-204:1762-1943) 10 20 30 40 pF1KE2 MGPLMVLFCLLFLYPGLADSAPSC-PQNVNISGGTFTLSHGWAPGS----- : : : . . :. .::.. :: XP_011 TVVYQCNPGFRLVGTSVRICLQDHKWSGQTPVCVPITCGHPGNP---AHGFTNGSEFNLN 1740 1750 1760 1770 1780 50 60 70 80 90 100 pF1KE2 -LLTYSCPQGLYPSPASRL-CKSSGQWQTPGATRSLSKAVCKPVRCPAPVSFENGIYTPR .....: : . .:: :.:.:::..: : :. : : : ::.: . XP_011 DVVNFTCNTGYLLQGVSRAQCRSNGQWSSPLPT-------CRVVNCSDPGFVENAIRHGQ 1790 1800 1810 1820 1830 1840 110 120 130 140 150 160 pF1KE2 LG---SYPVGGNVSFECEDGFILRGSPVRQCRPNGMWDGETAVCDNGAGHCPNPGISLGA . :. : .. ..:. :: : :: . : ::.:: : : : .::. .: XP_011 QNFPESFEYGMSILYHCKKGFYLLGSSALTCMANGLWDRSLPKC--LAISCGHPGVPANA 1850 1860 1870 1880 1890 170 180 190 200 210 220 pF1KE2 VRTGFRFGHGDKVRYRCSSNLVLTGSSERECQGNGVWSGTEPICRQPYSYDFPEDVAPAL : :: : .: :.: : .. : :.. : :: .. :::. : : XP_011 VLTGELFTYGAVVHYSCRGSESLIGNDTRVCQEDSHWSGALPHCTGNNPGFCGDPGTPAH 1900 1910 1920 1930 1940 1950 230 240 250 260 270 280 pF1KE2 GTSFSHMLGATNPTQKTKESLGRKIQIQRSGHLNLYLLLDCSQSVSENDFLIFKESASLM XP_011 GSRLGDDFKTKSLLRFSCEMGHQLRGSPERTCLLNGSWSGLQPVCEAVSCGNPGTPTNGM 1960 1970 1980 1990 2000 2010 >-- initn: 220 init1: 144 opt: 278 Z-score: 257.8 bits: 60.2 E(85289): 1.3e-07 Smith-Waterman score: 278; 33.3% identity (55.3% similar) in 159 aa overlap (44-199:1612-1759) 20 30 40 50 60 70 pF1KE2 YPGLADSAPSCPQNVNISGGTFTLSHGWAPGSLLTYSCPQGLYPSPASRL-CKSSGQWQT :. . :: : : : :...: :. XP_011 TCKPVACPSIEAQLSEHVIWRLVSGSLNEYGAQVLLSCSPGYYLEGWRLLRCQANGTWNI 1590 1600 1610 1620 1630 1640 80 90 100 110 120 130 pF1KE2 PGATRSLSKAVCKPVRCPAPVSFE-NGIYTPRLGSYPVGGNVS-FECEDGFILRGSPVRQ : : :. . : . .:: :: ..:. : : .. : :. :. : :: ::. XP_011 -GDERP----SCRVISCGS-LSFPPNG---NKIGTLTVYGATAIFTCNTGYTLVGSHVRE 1650 1660 1670 1680 1690 140 150 160 170 180 190 pF1KE2 CRPNGMWDGETAVCDNGAGHCPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLTGSSERE : ::.:.: . : :::: .: ... .: :.. : : :.:. .. :.:.: : XP_011 CLANGLWSGSETRCL--AGHCGSPDPIVNGHISGDGFSYRDTVVYQCNPGFRLVGTSVRI 1700 1710 1720 1730 1740 1750 200 210 220 230 240 250 pF1KE2 CQGNGVWSGTEPICRQPYSYDFPEDVAPALGTSFSHMLGATNPTQKTKESLGRKIQIQRS : . ::: XP_011 CLQDHKWSGQTPVCVPITCGHPGNPAHGFTNGSEFNLNDVVNFTCNTGYLLQGVSRAQCR 1760 1770 1780 1790 1800 1810 >>XP_016869220 (OMIM: 608397) PREDICTED: CUB and sushi d (3327 aa) initn: 597 init1: 165 opt: 360 Z-score: 332.2 bits: 74.3 E(85289): 9.2e-12 Smith-Waterman score: 380; 31.7% identity (56.2% similar) in 224 aa overlap (20-231:3028-3238) 10 20 30 40 pF1KE2 MGPLMVLFCLLFLYPGLADSAPSCPQNVNISGGTFTLSHGWAPGSLLT- .::.: .. : ::..: :. .: XP_016 SSSVIYACWEGYKTSGLMTRHCTANGTWTGTAPDC--TIISCGDPGTLANGIQFGTDFTF 3000 3010 3020 3030 3040 3050 50 60 70 80 90 100 pF1KE2 -----YSCPQGLYP---SPASRLCKSSGQWQTPGATRSLSKAVCKPVRCPAPVSFENGIY :.: : . :. : ..:.:. : :: ::: : :: : .:: XP_016 NKTVSYQCNPGYVMEAVTSATIRCTKDGRWN-P------SKPVCKAVLCPQPPPVQNG-- 3060 3070 3080 3090 3100 110 120 130 140 150 160 pF1KE2 TPRLGSYPVGGNVSFECEDGFILRGSPVRQCRPNGMWDGETAVCDNGAGHCPNPGISLGA : . ... :...:. : ::. : : . .:. :.: :: : : .::: . XP_016 TVEGSDFRWGSSISYSCMDGYQLSHSAILSCEGRGVWKGEIPQCL--PVFCGDPGIPAEG 3110 3120 3130 3140 3150 3160 170 180 190 200 210 220 pF1KE2 VRTGFRFGHGDKVRYRCSSNLVLTGSSERECQGNGVWSGTEPICRQPYSYDFPEDVAPAL .: : . ..: ..:.: ..:.:::.: ::..:.::: .: : .: :. .: . XP_016 RLSGKSFTYKSEVFFQCKSPFILVGSSRRVCQADGTWSGIQPTCIDPAHNTCPDPGTPHF 3170 3180 3190 3200 3210 3220 230 240 250 260 270 pF1KE2 G---TSFSHMLGATNPTQKTKESLGRKIQIQRSGHLNLYLLLDCSQSVSENDFLIFKESA : .: .. .:.: XP_016 GIQNSSRGYEVGSTVFFRCRKGYHIQGSTTRTCLANLTWSGIQTECILWFPRTGSITIGW 3230 3240 3250 3260 3270 3280 >-- initn: 446 init1: 151 opt: 335 Z-score: 309.1 bits: 70.0 E(85289): 1.8e-10 Smith-Waterman score: 335; 32.5% identity (53.6% similar) in 194 aa overlap (22-204:2731-2912) 10 20 30 40 pF1KE2 MGPLMVLFCLLFLYPGLADSAPSC-PQNVNISGGTFTLSHGWAPGS----- : : : . . :. .::.. :: XP_016 TVVYQCNPGFRLVGTSVRICLQDHKWSGQTPVCVPITCGHPGNP---AHGFTNGSEFNLN 2710 2720 2730 2740 2750 50 60 70 80 90 100 pF1KE2 -LLTYSCPQGLYPSPASRL-CKSSGQWQTPGATRSLSKAVCKPVRCPAPVSFENGIYTPR .....: : . .:: :.:.:::..: : :. : : : ::.: . XP_016 DVVNFTCNTGYLLQGVSRAQCRSNGQWSSPLPT-------CRVVNCSDPGFVENAIRHGQ 2760 2770 2780 2790 2800 2810 110 120 130 140 150 160 pF1KE2 LG---SYPVGGNVSFECEDGFILRGSPVRQCRPNGMWDGETAVCDNGAGHCPNPGISLGA . :. : .. ..:. :: : :: . : ::.:: : : : .::. .: XP_016 QNFPESFEYGMSILYHCKKGFYLLGSSALTCMANGLWDRSLPKC--LAISCGHPGVPANA 2820 2830 2840 2850 2860 170 180 190 200 210 220 pF1KE2 VRTGFRFGHGDKVRYRCSSNLVLTGSSERECQGNGVWSGTEPICRQPYSYDFPEDVAPAL : :: : .: :.: : .. : :.. : :: .. :::. : : XP_016 VLTGELFTYGAVVHYSCRGSESLIGNDTRVCQEDSHWSGALPHCTGNNPGFCGDPGTPAH 2870 2880 2890 2900 2910 2920 230 240 250 260 270 280 pF1KE2 GTSFSHMLGATNPTQKTKESLGRKIQIQRSGHLNLYLLLDCSQSVSENDFLIFKESASLM XP_016 GSRLGDDFKTKSLLRFSCEMGHQLRGSPERTCLLNGSWSGLQPVCEAVSCGNPGTPTNGM 2930 2940 2950 2960 2970 2980 752 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 20:30:55 2016 done: Sun Nov 6 20:30:56 2016 Total Scan time: 8.790 Total Display time: 0.120 Function used was FASTA [36.3.4 Apr, 2011]