FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE2101, 862 aa 1>>>pF1KE2101 862 - 862 aa - 862 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 11.6785+/-0.000426; mu= -8.4469+/- 0.027 mean_var=308.3795+/-62.817, 0's: 0 Z-trim(120.8): 296 B-trim: 0 in 0/58 Lambda= 0.073035 statistics sampled from 36149 (36449) to 36149 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.724), E-opt: 0.2 (0.427), width: 16 Scan time: 14.990 The best scores are: opt bits E(85289) NP_113671 (OMIM: 606409,613385) E3 ubiquitin-prote ( 862) 5943 640.3 1.1e-182 NP_001311127 (OMIM: 606409,613385) E3 ubiquitin-pr ( 862) 5943 640.3 1.1e-182 XP_016883579 (OMIM: 606409,613385) PREDICTED: E3 u ( 900) 5798 625.1 4.5e-178 NP_001244067 (OMIM: 606409,613385) E3 ubiquitin-pr ( 752) 5227 564.9 5e-160 XP_016883580 (OMIM: 606409,613385) PREDICTED: E3 u ( 752) 5227 564.9 5e-160 XP_016883578 (OMIM: 606409,613385) PREDICTED: E3 u ( 903) 4932 533.8 1.3e-150 NP_001311126 (OMIM: 606409,613385) E3 ubiquitin-pr ( 903) 4932 533.8 1.3e-150 NP_001244066 (OMIM: 606409,613385) E3 ubiquitin-pr ( 903) 4932 533.8 1.3e-150 XP_011527381 (OMIM: 606409,613385) PREDICTED: E3 u ( 692) 4825 522.5 2.6e-147 XP_005260627 (OMIM: 606409,613385) PREDICTED: E3 u ( 692) 4825 522.5 2.6e-147 XP_016878369 (OMIM: 602308) PREDICTED: NEDD4-like ( 870) 3296 361.4 1e-98 XP_011521125 (OMIM: 602308) PREDICTED: NEDD4-like ( 870) 3296 361.4 1e-98 NP_008945 (OMIM: 602308) NEDD4-like E3 ubiquitin-p ( 870) 3296 361.4 1e-98 XP_016878370 (OMIM: 602308) PREDICTED: NEDD4-like ( 870) 3296 361.4 1e-98 XP_011521127 (OMIM: 602308) PREDICTED: NEDD4-like ( 870) 3296 361.4 1e-98 XP_016878368 (OMIM: 602308) PREDICTED: NEDD4-like ( 870) 3296 361.4 1e-98 NP_001257383 (OMIM: 602308) NEDD4-like E3 ubiquiti ( 870) 3296 361.4 1e-98 XP_016868484 (OMIM: 602307) PREDICTED: NEDD4-like ( 743) 3247 356.2 3.2e-97 XP_016868485 (OMIM: 602307) PREDICTED: NEDD4-like ( 743) 3247 356.2 3.2e-97 XP_016868482 (OMIM: 602307) PREDICTED: NEDD4-like ( 921) 3247 356.3 3.8e-97 XP_005250818 (OMIM: 602307) PREDICTED: NEDD4-like ( 921) 3247 356.3 3.8e-97 XP_005250817 (OMIM: 602307) PREDICTED: NEDD4-like ( 922) 3247 356.3 3.8e-97 NP_008944 (OMIM: 602307) NEDD4-like E3 ubiquitin-p ( 922) 3247 356.3 3.8e-97 XP_011521128 (OMIM: 602308) PREDICTED: NEDD4-like ( 754) 3131 344.0 1.5e-93 NP_001257382 (OMIM: 602308) NEDD4-like E3 ubiquiti ( 754) 3131 344.0 1.5e-93 XP_016883581 (OMIM: 606409,613385) PREDICTED: E3 u ( 442) 2600 287.9 6.8e-77 NP_955456 (OMIM: 602308) NEDD4-like E3 ubiquitin-p ( 431) 2284 254.6 7e-67 XP_016868486 (OMIM: 602307) PREDICTED: NEDD4-like ( 719) 2107 236.1 4.4e-61 XP_011515104 (OMIM: 602307) PREDICTED: NEDD4-like ( 898) 2107 236.2 5.4e-61 XP_016868483 (OMIM: 602307) PREDICTED: NEDD4-like ( 898) 2107 236.2 5.4e-61 NP_001316141 (OMIM: 602278) E3 ubiquitin-protein l ( 753) 1678 190.9 1.9e-47 XP_011519929 (OMIM: 602278) PREDICTED: E3 ubiquiti ( 827) 1678 190.9 2e-47 XP_011519928 (OMIM: 602278) PREDICTED: E3 ubiquiti ( 849) 1678 190.9 2.1e-47 XP_011519927 (OMIM: 602278) PREDICTED: E3 ubiquiti ( 849) 1678 190.9 2.1e-47 XP_011519926 (OMIM: 602278) PREDICTED: E3 ubiquiti ( 875) 1678 190.9 2.1e-47 NP_006145 (OMIM: 602278) E3 ubiquitin-protein liga ( 900) 1678 191.0 2.2e-47 NP_940682 (OMIM: 602278) E3 ubiquitin-protein liga (1247) 1678 191.0 2.9e-47 NP_001271269 (OMIM: 602278) E3 ubiquitin-protein l (1302) 1678 191.0 3e-47 NP_001271268 (OMIM: 602278) E3 ubiquitin-protein l (1303) 1678 191.0 3e-47 NP_001271267 (OMIM: 602278) E3 ubiquitin-protein l (1319) 1678 191.0 3e-47 XP_016881170 (OMIM: 606384) PREDICTED: E3 ubiquiti ( 684) 1555 177.9 1.4e-43 XP_016881169 (OMIM: 606384) PREDICTED: E3 ubiquiti ( 750) 1555 178.0 1.5e-43 XP_006722488 (OMIM: 606384) PREDICTED: E3 ubiquiti ( 772) 1555 178.0 1.5e-43 NP_001138443 (OMIM: 606384) E3 ubiquitin-protein l ( 834) 1555 178.0 1.6e-43 NP_001138442 (OMIM: 606384) E3 ubiquitin-protein l ( 834) 1555 178.0 1.6e-43 XP_016881166 (OMIM: 606384) PREDICTED: E3 ubiquiti ( 838) 1555 178.0 1.6e-43 XP_016881168 (OMIM: 606384) PREDICTED: E3 ubiquiti ( 854) 1555 178.0 1.7e-43 NP_001138436 (OMIM: 606384) E3 ubiquitin-protein l ( 854) 1555 178.0 1.7e-43 NP_001138437 (OMIM: 606384) E3 ubiquitin-protein l ( 854) 1555 178.0 1.7e-43 NP_001138438 (OMIM: 606384) E3 ubiquitin-protein l ( 854) 1555 178.0 1.7e-43 >>NP_113671 (OMIM: 606409,613385) E3 ubiquitin-protein l (862 aa) initn: 5943 init1: 5943 opt: 5943 Z-score: 3400.7 bits: 640.3 E(85289): 1.1e-182 Smith-Waterman score: 5943; 100.0% identity (100.0% similar) in 862 aa overlap (1-862:1-862) 10 20 30 40 50 60 pF1KE2 MSDSGSQLGSMGSLTMKSQLQITVISAKLKENKKNWFGPSPYVEVTVDGQSKKTEKCNNT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_113 MSDSGSQLGSMGSLTMKSQLQITVISAKLKENKKNWFGPSPYVEVTVDGQSKKTEKCNNT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 NSPKWKQPLTVIVTPVSKLHFRVWSHQTLKSDVLLGTAALDIYETLKSNNMKLEEVVVTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_113 NSPKWKQPLTVIVTPVSKLHFRVWSHQTLKSDVLLGTAALDIYETLKSNNMKLEEVVVTL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 QLGGDKEPTETIGDLSICLDGLQLESEVVTNGETTCSESASQNDDGSRSKDETRVSTNGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_113 QLGGDKEPTETIGDLSICLDGLQLESEVVTNGETTCSESASQNDDGSRSKDETRVSTNGS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 DDPEDAGAGENRRVSGNNSPSLSNGGFKPSRPPRPSRPPPPTPRRPASVNGSPSATSESD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_113 DDPEDAGAGENRRVSGNNSPSLSNGGFKPSRPPRPSRPPPPTPRRPASVNGSPSATSESD 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 GSSTGSLPPTNTNTNTSEGATSGLIIPLTISGGSGPRPLNPVTQAPLPPGWEQRVDQHGR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_113 GSSTGSLPPTNTNTNTSEGATSGLIIPLTISGGSGPRPLNPVTQAPLPPGWEQRVDQHGR 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 VYYVDHVEKRTTWDRPEPLPPGWERRVDNMGRIYYVDHFTRTTTWQRPTLESVRNYEQWQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_113 VYYVDHVEKRTTWDRPEPLPPGWERRVDNMGRIYYVDHFTRTTTWQRPTLESVRNYEQWQ 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 LQRSQLQGAMQQFNQRFIYGNQDLFATSQSKEFDPLGPLPPGWEKRTDSNGRVYFVNHNT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_113 LQRSQLQGAMQQFNQRFIYGNQDLFATSQSKEFDPLGPLPPGWEKRTDSNGRVYFVNHNT 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE2 RITQWEDPRSQGQLNEKPLPEGWEMRFTVDGIPYFVDHNRRTTTYIDPRTGKSALDNGPQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_113 RITQWEDPRSQGQLNEKPLPEGWEMRFTVDGIPYFVDHNRRTTTYIDPRTGKSALDNGPQ 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE2 IAYVRDFKAKVQYFRFWCQQLAMPQHIKITVTRKTLFEDSFQQIMSFSPQDLRRRLWVIF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_113 IAYVRDFKAKVQYFRFWCQQLAMPQHIKITVTRKTLFEDSFQQIMSFSPQDLRRRLWVIF 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE2 PGEEGLDYGGVAREWFFLLSHEVLNPMYCLFEYAGKDNYCLQINPASYINPDHLKYFRFI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_113 PGEEGLDYGGVAREWFFLLSHEVLNPMYCLFEYAGKDNYCLQINPASYINPDHLKYFRFI 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE2 GRFIAMALFHGKFIDTGFSLPFYKRILNKPVGLKDLESIDPEFYNSLIWVKENNIEECDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_113 GRFIAMALFHGKFIDTGFSLPFYKRILNKPVGLKDLESIDPEFYNSLIWVKENNIEECDL 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE2 EMYFSVDKEILGEIKSHDLKPNGGNILVTEENKEEYIRMVAEWRLSRGVEEQTQAFFEGF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_113 EMYFSVDKEILGEIKSHDLKPNGGNILVTEENKEEYIRMVAEWRLSRGVEEQTQAFFEGF 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE2 NEILPQQYLQYFDAKELEVLLCGMQEIDLNDWQRHAIYRHYARTSKQIMWFWQFVKEIDN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_113 NEILPQQYLQYFDAKELEVLLCGMQEIDLNDWQRHAIYRHYARTSKQIMWFWQFVKEIDN 730 740 750 760 770 780 790 800 810 820 830 840 pF1KE2 EKRMRLLQFVTGTCRLPVGGFADLMGSNGPQKFCIEKVGKENWLPRSHTCFNRLDLPPYK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_113 EKRMRLLQFVTGTCRLPVGGFADLMGSNGPQKFCIEKVGKENWLPRSHTCFNRLDLPPYK 790 800 810 820 830 840 850 860 pF1KE2 SYEQLKEKLLFAIEETEGFGQE :::::::::::::::::::::: NP_113 SYEQLKEKLLFAIEETEGFGQE 850 860 >>NP_001311127 (OMIM: 606409,613385) E3 ubiquitin-protei (862 aa) initn: 5943 init1: 5943 opt: 5943 Z-score: 3400.7 bits: 640.3 E(85289): 1.1e-182 Smith-Waterman score: 5943; 100.0% identity (100.0% similar) in 862 aa overlap (1-862:1-862) 10 20 30 40 50 60 pF1KE2 MSDSGSQLGSMGSLTMKSQLQITVISAKLKENKKNWFGPSPYVEVTVDGQSKKTEKCNNT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MSDSGSQLGSMGSLTMKSQLQITVISAKLKENKKNWFGPSPYVEVTVDGQSKKTEKCNNT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 NSPKWKQPLTVIVTPVSKLHFRVWSHQTLKSDVLLGTAALDIYETLKSNNMKLEEVVVTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NSPKWKQPLTVIVTPVSKLHFRVWSHQTLKSDVLLGTAALDIYETLKSNNMKLEEVVVTL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 QLGGDKEPTETIGDLSICLDGLQLESEVVTNGETTCSESASQNDDGSRSKDETRVSTNGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QLGGDKEPTETIGDLSICLDGLQLESEVVTNGETTCSESASQNDDGSRSKDETRVSTNGS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 DDPEDAGAGENRRVSGNNSPSLSNGGFKPSRPPRPSRPPPPTPRRPASVNGSPSATSESD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DDPEDAGAGENRRVSGNNSPSLSNGGFKPSRPPRPSRPPPPTPRRPASVNGSPSATSESD 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 GSSTGSLPPTNTNTNTSEGATSGLIIPLTISGGSGPRPLNPVTQAPLPPGWEQRVDQHGR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GSSTGSLPPTNTNTNTSEGATSGLIIPLTISGGSGPRPLNPVTQAPLPPGWEQRVDQHGR 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 VYYVDHVEKRTTWDRPEPLPPGWERRVDNMGRIYYVDHFTRTTTWQRPTLESVRNYEQWQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VYYVDHVEKRTTWDRPEPLPPGWERRVDNMGRIYYVDHFTRTTTWQRPTLESVRNYEQWQ 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 LQRSQLQGAMQQFNQRFIYGNQDLFATSQSKEFDPLGPLPPGWEKRTDSNGRVYFVNHNT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LQRSQLQGAMQQFNQRFIYGNQDLFATSQSKEFDPLGPLPPGWEKRTDSNGRVYFVNHNT 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE2 RITQWEDPRSQGQLNEKPLPEGWEMRFTVDGIPYFVDHNRRTTTYIDPRTGKSALDNGPQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RITQWEDPRSQGQLNEKPLPEGWEMRFTVDGIPYFVDHNRRTTTYIDPRTGKSALDNGPQ 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE2 IAYVRDFKAKVQYFRFWCQQLAMPQHIKITVTRKTLFEDSFQQIMSFSPQDLRRRLWVIF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IAYVRDFKAKVQYFRFWCQQLAMPQHIKITVTRKTLFEDSFQQIMSFSPQDLRRRLWVIF 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE2 PGEEGLDYGGVAREWFFLLSHEVLNPMYCLFEYAGKDNYCLQINPASYINPDHLKYFRFI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PGEEGLDYGGVAREWFFLLSHEVLNPMYCLFEYAGKDNYCLQINPASYINPDHLKYFRFI 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE2 GRFIAMALFHGKFIDTGFSLPFYKRILNKPVGLKDLESIDPEFYNSLIWVKENNIEECDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GRFIAMALFHGKFIDTGFSLPFYKRILNKPVGLKDLESIDPEFYNSLIWVKENNIEECDL 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE2 EMYFSVDKEILGEIKSHDLKPNGGNILVTEENKEEYIRMVAEWRLSRGVEEQTQAFFEGF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EMYFSVDKEILGEIKSHDLKPNGGNILVTEENKEEYIRMVAEWRLSRGVEEQTQAFFEGF 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE2 NEILPQQYLQYFDAKELEVLLCGMQEIDLNDWQRHAIYRHYARTSKQIMWFWQFVKEIDN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NEILPQQYLQYFDAKELEVLLCGMQEIDLNDWQRHAIYRHYARTSKQIMWFWQFVKEIDN 730 740 750 760 770 780 790 800 810 820 830 840 pF1KE2 EKRMRLLQFVTGTCRLPVGGFADLMGSNGPQKFCIEKVGKENWLPRSHTCFNRLDLPPYK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EKRMRLLQFVTGTCRLPVGGFADLMGSNGPQKFCIEKVGKENWLPRSHTCFNRLDLPPYK 790 800 810 820 830 840 850 860 pF1KE2 SYEQLKEKLLFAIEETEGFGQE :::::::::::::::::::::: NP_001 SYEQLKEKLLFAIEETEGFGQE 850 860 >>XP_016883579 (OMIM: 606409,613385) PREDICTED: E3 ubiqu (900 aa) initn: 5924 init1: 5798 opt: 5798 Z-score: 3317.9 bits: 625.1 E(85289): 4.5e-178 Smith-Waterman score: 5813; 95.6% identity (95.6% similar) in 894 aa overlap (7-862:7-900) 10 20 pF1KE2 MSDSGSQLGSMGSLTMKSQLQIT------------------------------------- ::::::::::::::::: XP_016 MSDSGSQLGSMGSLTMKSQLQITETRFHHLDQAGLELLTSGSTHLGLPKYRDYRREPPRP 10 20 30 40 50 60 30 40 50 60 70 80 pF1KE2 -VISAKLKENKKNWFGPSPYVEVTVDGQSKKTEKCNNTNSPKWKQPLTVIVTPVSKLHFR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AFISAKLKENKKNWFGPSPYVEVTVDGQSKKTEKCNNTNSPKWKQPLTVIVTPVSKLHFR 70 80 90 100 110 120 90 100 110 120 130 140 pF1KE2 VWSHQTLKSDVLLGTAALDIYETLKSNNMKLEEVVVTLQLGGDKEPTETIGDLSICLDGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VWSHQTLKSDVLLGTAALDIYETLKSNNMKLEEVVVTLQLGGDKEPTETIGDLSICLDGL 130 140 150 160 170 180 150 160 170 180 190 200 pF1KE2 QLESEVVTNGETTCSESASQNDDGSRSKDETRVSTNGSDDPEDAGAGENRRVSGNNSPSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QLESEVVTNGETTCSESASQNDDGSRSKDETRVSTNGSDDPEDAGAGENRRVSGNNSPSL 190 200 210 220 230 240 210 220 230 240 250 260 pF1KE2 SNGGFKPSRPPRPSRPPPPTPRRPASVNGSPSATSESDGSSTGSLPPTNTNTNTSEGATS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SNGGFKPSRPPRPSRPPPPTPRRPASVNGSPSATSESDGSSTGSLPPTNTNTNTSEGATS 250 260 270 280 290 300 270 280 290 300 310 320 pF1KE2 GLIIPLTISGGSGPRPLNPVTQAPLPPGWEQRVDQHGRVYYVDHVEKRTTWDRPEPLPPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GLIIPLTISGGSGPRPLNPVTQAPLPPGWEQRVDQHGRVYYVDHVEKRTTWDRPEPLPPG 310 320 330 340 350 360 330 340 350 360 370 380 pF1KE2 WERRVDNMGRIYYVDHFTRTTTWQRPTLESVRNYEQWQLQRSQLQGAMQQFNQRFIYGNQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 WERRVDNMGRIYYVDHFTRTTTWQRPTLESVRNYEQWQLQRSQLQGAMQQFNQRFIYGNQ 370 380 390 400 410 420 390 400 410 420 430 440 pF1KE2 DLFATSQSKEFDPLGPLPPGWEKRTDSNGRVYFVNHNTRITQWEDPRSQGQLNEKPLPEG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DLFATSQSKEFDPLGPLPPGWEKRTDSNGRVYFVNHNTRITQWEDPRSQGQLNEKPLPEG 430 440 450 460 470 480 450 460 470 480 490 500 pF1KE2 WEMRFTVDGIPYFVDHNRRTTTYIDPRTGKSALDNGPQIAYVRDFKAKVQYFRFWCQQLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 WEMRFTVDGIPYFVDHNRRTTTYIDPRTGKSALDNGPQIAYVRDFKAKVQYFRFWCQQLA 490 500 510 520 530 540 510 520 530 540 550 560 pF1KE2 MPQHIKITVTRKTLFEDSFQQIMSFSPQDLRRRLWVIFPGEEGLDYGGVAREWFFLLSHE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MPQHIKITVTRKTLFEDSFQQIMSFSPQDLRRRLWVIFPGEEGLDYGGVAREWFFLLSHE 550 560 570 580 590 600 570 580 590 600 610 620 pF1KE2 VLNPMYCLFEYAGKDNYCLQINPASYINPDHLKYFRFIGRFIAMALFHGKFIDTGFSLPF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VLNPMYCLFEYAGKDNYCLQINPASYINPDHLKYFRFIGRFIAMALFHGKFIDTGFSLPF 610 620 630 640 650 660 630 640 650 660 670 680 pF1KE2 YKRILNKPVGLKDLESIDPEFYNSLIWVKENNIEECDLEMYFSVDKEILGEIKSHDLKPN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YKRILNKPVGLKDLESIDPEFYNSLIWVKENNIEECDLEMYFSVDKEILGEIKSHDLKPN 670 680 690 700 710 720 690 700 710 720 730 740 pF1KE2 GGNILVTEENKEEYIRMVAEWRLSRGVEEQTQAFFEGFNEILPQQYLQYFDAKELEVLLC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GGNILVTEENKEEYIRMVAEWRLSRGVEEQTQAFFEGFNEILPQQYLQYFDAKELEVLLC 730 740 750 760 770 780 750 760 770 780 790 800 pF1KE2 GMQEIDLNDWQRHAIYRHYARTSKQIMWFWQFVKEIDNEKRMRLLQFVTGTCRLPVGGFA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GMQEIDLNDWQRHAIYRHYARTSKQIMWFWQFVKEIDNEKRMRLLQFVTGTCRLPVGGFA 790 800 810 820 830 840 810 820 830 840 850 860 pF1KE2 DLMGSNGPQKFCIEKVGKENWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGFGQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DLMGSNGPQKFCIEKVGKENWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGFGQE 850 860 870 880 890 900 >>NP_001244067 (OMIM: 606409,613385) E3 ubiquitin-protei (752 aa) initn: 5227 init1: 5227 opt: 5227 Z-score: 2993.9 bits: 564.9 E(85289): 5e-160 Smith-Waterman score: 5227; 100.0% identity (100.0% similar) in 752 aa overlap (111-862:1-752) 90 100 110 120 130 140 pF1KE2 FRVWSHQTLKSDVLLGTAALDIYETLKSNNMKLEEVVVTLQLGGDKEPTETIGDLSICLD :::::::::::::::::::::::::::::: NP_001 MKLEEVVVTLQLGGDKEPTETIGDLSICLD 10 20 30 150 160 170 180 190 200 pF1KE2 GLQLESEVVTNGETTCSESASQNDDGSRSKDETRVSTNGSDDPEDAGAGENRRVSGNNSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GLQLESEVVTNGETTCSESASQNDDGSRSKDETRVSTNGSDDPEDAGAGENRRVSGNNSP 40 50 60 70 80 90 210 220 230 240 250 260 pF1KE2 SLSNGGFKPSRPPRPSRPPPPTPRRPASVNGSPSATSESDGSSTGSLPPTNTNTNTSEGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SLSNGGFKPSRPPRPSRPPPPTPRRPASVNGSPSATSESDGSSTGSLPPTNTNTNTSEGA 100 110 120 130 140 150 270 280 290 300 310 320 pF1KE2 TSGLIIPLTISGGSGPRPLNPVTQAPLPPGWEQRVDQHGRVYYVDHVEKRTTWDRPEPLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TSGLIIPLTISGGSGPRPLNPVTQAPLPPGWEQRVDQHGRVYYVDHVEKRTTWDRPEPLP 160 170 180 190 200 210 330 340 350 360 370 380 pF1KE2 PGWERRVDNMGRIYYVDHFTRTTTWQRPTLESVRNYEQWQLQRSQLQGAMQQFNQRFIYG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PGWERRVDNMGRIYYVDHFTRTTTWQRPTLESVRNYEQWQLQRSQLQGAMQQFNQRFIYG 220 230 240 250 260 270 390 400 410 420 430 440 pF1KE2 NQDLFATSQSKEFDPLGPLPPGWEKRTDSNGRVYFVNHNTRITQWEDPRSQGQLNEKPLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NQDLFATSQSKEFDPLGPLPPGWEKRTDSNGRVYFVNHNTRITQWEDPRSQGQLNEKPLP 280 290 300 310 320 330 450 460 470 480 490 500 pF1KE2 EGWEMRFTVDGIPYFVDHNRRTTTYIDPRTGKSALDNGPQIAYVRDFKAKVQYFRFWCQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EGWEMRFTVDGIPYFVDHNRRTTTYIDPRTGKSALDNGPQIAYVRDFKAKVQYFRFWCQQ 340 350 360 370 380 390 510 520 530 540 550 560 pF1KE2 LAMPQHIKITVTRKTLFEDSFQQIMSFSPQDLRRRLWVIFPGEEGLDYGGVAREWFFLLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LAMPQHIKITVTRKTLFEDSFQQIMSFSPQDLRRRLWVIFPGEEGLDYGGVAREWFFLLS 400 410 420 430 440 450 570 580 590 600 610 620 pF1KE2 HEVLNPMYCLFEYAGKDNYCLQINPASYINPDHLKYFRFIGRFIAMALFHGKFIDTGFSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HEVLNPMYCLFEYAGKDNYCLQINPASYINPDHLKYFRFIGRFIAMALFHGKFIDTGFSL 460 470 480 490 500 510 630 640 650 660 670 680 pF1KE2 PFYKRILNKPVGLKDLESIDPEFYNSLIWVKENNIEECDLEMYFSVDKEILGEIKSHDLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PFYKRILNKPVGLKDLESIDPEFYNSLIWVKENNIEECDLEMYFSVDKEILGEIKSHDLK 520 530 540 550 560 570 690 700 710 720 730 740 pF1KE2 PNGGNILVTEENKEEYIRMVAEWRLSRGVEEQTQAFFEGFNEILPQQYLQYFDAKELEVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PNGGNILVTEENKEEYIRMVAEWRLSRGVEEQTQAFFEGFNEILPQQYLQYFDAKELEVL 580 590 600 610 620 630 750 760 770 780 790 800 pF1KE2 LCGMQEIDLNDWQRHAIYRHYARTSKQIMWFWQFVKEIDNEKRMRLLQFVTGTCRLPVGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LCGMQEIDLNDWQRHAIYRHYARTSKQIMWFWQFVKEIDNEKRMRLLQFVTGTCRLPVGG 640 650 660 670 680 690 810 820 830 840 850 860 pF1KE2 FADLMGSNGPQKFCIEKVGKENWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGFG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FADLMGSNGPQKFCIEKVGKENWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGFG 700 710 720 730 740 750 pF1KE2 QE :: NP_001 QE >>XP_016883580 (OMIM: 606409,613385) PREDICTED: E3 ubiqu (752 aa) initn: 5227 init1: 5227 opt: 5227 Z-score: 2993.9 bits: 564.9 E(85289): 5e-160 Smith-Waterman score: 5227; 100.0% identity (100.0% similar) in 752 aa overlap (111-862:1-752) 90 100 110 120 130 140 pF1KE2 FRVWSHQTLKSDVLLGTAALDIYETLKSNNMKLEEVVVTLQLGGDKEPTETIGDLSICLD :::::::::::::::::::::::::::::: XP_016 MKLEEVVVTLQLGGDKEPTETIGDLSICLD 10 20 30 150 160 170 180 190 200 pF1KE2 GLQLESEVVTNGETTCSESASQNDDGSRSKDETRVSTNGSDDPEDAGAGENRRVSGNNSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GLQLESEVVTNGETTCSESASQNDDGSRSKDETRVSTNGSDDPEDAGAGENRRVSGNNSP 40 50 60 70 80 90 210 220 230 240 250 260 pF1KE2 SLSNGGFKPSRPPRPSRPPPPTPRRPASVNGSPSATSESDGSSTGSLPPTNTNTNTSEGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SLSNGGFKPSRPPRPSRPPPPTPRRPASVNGSPSATSESDGSSTGSLPPTNTNTNTSEGA 100 110 120 130 140 150 270 280 290 300 310 320 pF1KE2 TSGLIIPLTISGGSGPRPLNPVTQAPLPPGWEQRVDQHGRVYYVDHVEKRTTWDRPEPLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TSGLIIPLTISGGSGPRPLNPVTQAPLPPGWEQRVDQHGRVYYVDHVEKRTTWDRPEPLP 160 170 180 190 200 210 330 340 350 360 370 380 pF1KE2 PGWERRVDNMGRIYYVDHFTRTTTWQRPTLESVRNYEQWQLQRSQLQGAMQQFNQRFIYG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PGWERRVDNMGRIYYVDHFTRTTTWQRPTLESVRNYEQWQLQRSQLQGAMQQFNQRFIYG 220 230 240 250 260 270 390 400 410 420 430 440 pF1KE2 NQDLFATSQSKEFDPLGPLPPGWEKRTDSNGRVYFVNHNTRITQWEDPRSQGQLNEKPLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NQDLFATSQSKEFDPLGPLPPGWEKRTDSNGRVYFVNHNTRITQWEDPRSQGQLNEKPLP 280 290 300 310 320 330 450 460 470 480 490 500 pF1KE2 EGWEMRFTVDGIPYFVDHNRRTTTYIDPRTGKSALDNGPQIAYVRDFKAKVQYFRFWCQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EGWEMRFTVDGIPYFVDHNRRTTTYIDPRTGKSALDNGPQIAYVRDFKAKVQYFRFWCQQ 340 350 360 370 380 390 510 520 530 540 550 560 pF1KE2 LAMPQHIKITVTRKTLFEDSFQQIMSFSPQDLRRRLWVIFPGEEGLDYGGVAREWFFLLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LAMPQHIKITVTRKTLFEDSFQQIMSFSPQDLRRRLWVIFPGEEGLDYGGVAREWFFLLS 400 410 420 430 440 450 570 580 590 600 610 620 pF1KE2 HEVLNPMYCLFEYAGKDNYCLQINPASYINPDHLKYFRFIGRFIAMALFHGKFIDTGFSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HEVLNPMYCLFEYAGKDNYCLQINPASYINPDHLKYFRFIGRFIAMALFHGKFIDTGFSL 460 470 480 490 500 510 630 640 650 660 670 680 pF1KE2 PFYKRILNKPVGLKDLESIDPEFYNSLIWVKENNIEECDLEMYFSVDKEILGEIKSHDLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PFYKRILNKPVGLKDLESIDPEFYNSLIWVKENNIEECDLEMYFSVDKEILGEIKSHDLK 520 530 540 550 560 570 690 700 710 720 730 740 pF1KE2 PNGGNILVTEENKEEYIRMVAEWRLSRGVEEQTQAFFEGFNEILPQQYLQYFDAKELEVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PNGGNILVTEENKEEYIRMVAEWRLSRGVEEQTQAFFEGFNEILPQQYLQYFDAKELEVL 580 590 600 610 620 630 750 760 770 780 790 800 pF1KE2 LCGMQEIDLNDWQRHAIYRHYARTSKQIMWFWQFVKEIDNEKRMRLLQFVTGTCRLPVGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LCGMQEIDLNDWQRHAIYRHYARTSKQIMWFWQFVKEIDNEKRMRLLQFVTGTCRLPVGG 640 650 660 670 680 690 810 820 830 840 850 860 pF1KE2 FADLMGSNGPQKFCIEKVGKENWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGFG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FADLMGSNGPQKFCIEKVGKENWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGFG 700 710 720 730 740 750 pF1KE2 QE :: XP_016 QE >>XP_016883578 (OMIM: 606409,613385) PREDICTED: E3 ubiqu (903 aa) initn: 5925 init1: 4919 opt: 4932 Z-score: 2824.7 bits: 533.8 E(85289): 1.3e-150 Smith-Waterman score: 5789; 95.3% identity (95.4% similar) in 894 aa overlap (10-862:10-903) 10 20 30 40 50 60 pF1KE2 MSDSGSQLGSMGSLTMKSQLQITVISAKLKENKKNWFGPSPYVEVTVDGQSKKTEKCNNT ::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MSDSGSQLGSMGSLTMKSQLQITVISAKLKENKKNWFGPSPYVEVTVDGQSKKTEKCNNT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 NSPKWKQPLTVIVTPVSKLHFRVWSHQTLKSDVLLGTAALDIYETLKSNNMKLEEVVVTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NSPKWKQPLTVIVTPVSKLHFRVWSHQTLKSDVLLGTAALDIYETLKSNNMKLEEVVVTL 70 80 90 100 110 120 130 140 150 pF1KE2 QLGGDKEPTETIGDLSICLDGLQLESEVVTNGETTCSES--------------------- ::::::::::::::::::::::::::::::::::::::. XP_016 QLGGDKEPTETIGDLSICLDGLQLESEVVTNGETTCSENGVSLCLPRLECNSAISAHCNL 130 140 150 160 170 180 160 170 180 190 pF1KE2 --------------------ASQNDDGSRSKDETRVSTNGSDDPEDAGAGENRRVSGNNS :::::::::::::::::::::::::::::::::::::::: XP_016 CLPGLSDSPISASRVAGFTGASQNDDGSRSKDETRVSTNGSDDPEDAGAGENRRVSGNNS 190 200 210 220 230 240 200 210 220 230 240 250 pF1KE2 PSLSNGGFKPSRPPRPSRPPPPTPRRPASVNGSPSATSESDGSSTGSLPPTNTNTNTSEG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PSLSNGGFKPSRPPRPSRPPPPTPRRPASVNGSPSATSESDGSSTGSLPPTNTNTNTSEG 250 260 270 280 290 300 260 270 280 290 300 310 pF1KE2 ATSGLIIPLTISGGSGPRPLNPVTQAPLPPGWEQRVDQHGRVYYVDHVEKRTTWDRPEPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ATSGLIIPLTISGGSGPRPLNPVTQAPLPPGWEQRVDQHGRVYYVDHVEKRTTWDRPEPL 310 320 330 340 350 360 320 330 340 350 360 370 pF1KE2 PPGWERRVDNMGRIYYVDHFTRTTTWQRPTLESVRNYEQWQLQRSQLQGAMQQFNQRFIY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PPGWERRVDNMGRIYYVDHFTRTTTWQRPTLESVRNYEQWQLQRSQLQGAMQQFNQRFIY 370 380 390 400 410 420 380 390 400 410 420 430 pF1KE2 GNQDLFATSQSKEFDPLGPLPPGWEKRTDSNGRVYFVNHNTRITQWEDPRSQGQLNEKPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GNQDLFATSQSKEFDPLGPLPPGWEKRTDSNGRVYFVNHNTRITQWEDPRSQGQLNEKPL 430 440 450 460 470 480 440 450 460 470 480 490 pF1KE2 PEGWEMRFTVDGIPYFVDHNRRTTTYIDPRTGKSALDNGPQIAYVRDFKAKVQYFRFWCQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PEGWEMRFTVDGIPYFVDHNRRTTTYIDPRTGKSALDNGPQIAYVRDFKAKVQYFRFWCQ 490 500 510 520 530 540 500 510 520 530 540 550 pF1KE2 QLAMPQHIKITVTRKTLFEDSFQQIMSFSPQDLRRRLWVIFPGEEGLDYGGVAREWFFLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QLAMPQHIKITVTRKTLFEDSFQQIMSFSPQDLRRRLWVIFPGEEGLDYGGVAREWFFLL 550 560 570 580 590 600 560 570 580 590 600 610 pF1KE2 SHEVLNPMYCLFEYAGKDNYCLQINPASYINPDHLKYFRFIGRFIAMALFHGKFIDTGFS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SHEVLNPMYCLFEYAGKDNYCLQINPASYINPDHLKYFRFIGRFIAMALFHGKFIDTGFS 610 620 630 640 650 660 620 630 640 650 660 670 pF1KE2 LPFYKRILNKPVGLKDLESIDPEFYNSLIWVKENNIEECDLEMYFSVDKEILGEIKSHDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LPFYKRILNKPVGLKDLESIDPEFYNSLIWVKENNIEECDLEMYFSVDKEILGEIKSHDL 670 680 690 700 710 720 680 690 700 710 720 730 pF1KE2 KPNGGNILVTEENKEEYIRMVAEWRLSRGVEEQTQAFFEGFNEILPQQYLQYFDAKELEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KPNGGNILVTEENKEEYIRMVAEWRLSRGVEEQTQAFFEGFNEILPQQYLQYFDAKELEV 730 740 750 760 770 780 740 750 760 770 780 790 pF1KE2 LLCGMQEIDLNDWQRHAIYRHYARTSKQIMWFWQFVKEIDNEKRMRLLQFVTGTCRLPVG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LLCGMQEIDLNDWQRHAIYRHYARTSKQIMWFWQFVKEIDNEKRMRLLQFVTGTCRLPVG 790 800 810 820 830 840 800 810 820 830 840 850 pF1KE2 GFADLMGSNGPQKFCIEKVGKENWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GFADLMGSNGPQKFCIEKVGKENWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGF 850 860 870 880 890 900 860 pF1KE2 GQE ::: XP_016 GQE >>NP_001311126 (OMIM: 606409,613385) E3 ubiquitin-protei (903 aa) initn: 5925 init1: 4919 opt: 4932 Z-score: 2824.7 bits: 533.8 E(85289): 1.3e-150 Smith-Waterman score: 5789; 95.3% identity (95.4% similar) in 894 aa overlap (10-862:10-903) 10 20 30 40 50 60 pF1KE2 MSDSGSQLGSMGSLTMKSQLQITVISAKLKENKKNWFGPSPYVEVTVDGQSKKTEKCNNT ::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MSDSGSQLGSMGSLTMKSQLQITVISAKLKENKKNWFGPSPYVEVTVDGQSKKTEKCNNT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 NSPKWKQPLTVIVTPVSKLHFRVWSHQTLKSDVLLGTAALDIYETLKSNNMKLEEVVVTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NSPKWKQPLTVIVTPVSKLHFRVWSHQTLKSDVLLGTAALDIYETLKSNNMKLEEVVVTL 70 80 90 100 110 120 130 140 150 pF1KE2 QLGGDKEPTETIGDLSICLDGLQLESEVVTNGETTCSES--------------------- ::::::::::::::::::::::::::::::::::::::. NP_001 QLGGDKEPTETIGDLSICLDGLQLESEVVTNGETTCSENGVSLCLPRLECNSAISAHCNL 130 140 150 160 170 180 160 170 180 190 pF1KE2 --------------------ASQNDDGSRSKDETRVSTNGSDDPEDAGAGENRRVSGNNS :::::::::::::::::::::::::::::::::::::::: NP_001 CLPGLSDSPISASRVAGFTGASQNDDGSRSKDETRVSTNGSDDPEDAGAGENRRVSGNNS 190 200 210 220 230 240 200 210 220 230 240 250 pF1KE2 PSLSNGGFKPSRPPRPSRPPPPTPRRPASVNGSPSATSESDGSSTGSLPPTNTNTNTSEG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PSLSNGGFKPSRPPRPSRPPPPTPRRPASVNGSPSATSESDGSSTGSLPPTNTNTNTSEG 250 260 270 280 290 300 260 270 280 290 300 310 pF1KE2 ATSGLIIPLTISGGSGPRPLNPVTQAPLPPGWEQRVDQHGRVYYVDHVEKRTTWDRPEPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ATSGLIIPLTISGGSGPRPLNPVTQAPLPPGWEQRVDQHGRVYYVDHVEKRTTWDRPEPL 310 320 330 340 350 360 320 330 340 350 360 370 pF1KE2 PPGWERRVDNMGRIYYVDHFTRTTTWQRPTLESVRNYEQWQLQRSQLQGAMQQFNQRFIY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PPGWERRVDNMGRIYYVDHFTRTTTWQRPTLESVRNYEQWQLQRSQLQGAMQQFNQRFIY 370 380 390 400 410 420 380 390 400 410 420 430 pF1KE2 GNQDLFATSQSKEFDPLGPLPPGWEKRTDSNGRVYFVNHNTRITQWEDPRSQGQLNEKPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GNQDLFATSQSKEFDPLGPLPPGWEKRTDSNGRVYFVNHNTRITQWEDPRSQGQLNEKPL 430 440 450 460 470 480 440 450 460 470 480 490 pF1KE2 PEGWEMRFTVDGIPYFVDHNRRTTTYIDPRTGKSALDNGPQIAYVRDFKAKVQYFRFWCQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PEGWEMRFTVDGIPYFVDHNRRTTTYIDPRTGKSALDNGPQIAYVRDFKAKVQYFRFWCQ 490 500 510 520 530 540 500 510 520 530 540 550 pF1KE2 QLAMPQHIKITVTRKTLFEDSFQQIMSFSPQDLRRRLWVIFPGEEGLDYGGVAREWFFLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QLAMPQHIKITVTRKTLFEDSFQQIMSFSPQDLRRRLWVIFPGEEGLDYGGVAREWFFLL 550 560 570 580 590 600 560 570 580 590 600 610 pF1KE2 SHEVLNPMYCLFEYAGKDNYCLQINPASYINPDHLKYFRFIGRFIAMALFHGKFIDTGFS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SHEVLNPMYCLFEYAGKDNYCLQINPASYINPDHLKYFRFIGRFIAMALFHGKFIDTGFS 610 620 630 640 650 660 620 630 640 650 660 670 pF1KE2 LPFYKRILNKPVGLKDLESIDPEFYNSLIWVKENNIEECDLEMYFSVDKEILGEIKSHDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LPFYKRILNKPVGLKDLESIDPEFYNSLIWVKENNIEECDLEMYFSVDKEILGEIKSHDL 670 680 690 700 710 720 680 690 700 710 720 730 pF1KE2 KPNGGNILVTEENKEEYIRMVAEWRLSRGVEEQTQAFFEGFNEILPQQYLQYFDAKELEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KPNGGNILVTEENKEEYIRMVAEWRLSRGVEEQTQAFFEGFNEILPQQYLQYFDAKELEV 730 740 750 760 770 780 740 750 760 770 780 790 pF1KE2 LLCGMQEIDLNDWQRHAIYRHYARTSKQIMWFWQFVKEIDNEKRMRLLQFVTGTCRLPVG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LLCGMQEIDLNDWQRHAIYRHYARTSKQIMWFWQFVKEIDNEKRMRLLQFVTGTCRLPVG 790 800 810 820 830 840 800 810 820 830 840 850 pF1KE2 GFADLMGSNGPQKFCIEKVGKENWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GFADLMGSNGPQKFCIEKVGKENWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGF 850 860 870 880 890 900 860 pF1KE2 GQE ::: NP_001 GQE >>NP_001244066 (OMIM: 606409,613385) E3 ubiquitin-protei (903 aa) initn: 5925 init1: 4919 opt: 4932 Z-score: 2824.7 bits: 533.8 E(85289): 1.3e-150 Smith-Waterman score: 5789; 95.3% identity (95.4% similar) in 894 aa overlap (10-862:10-903) 10 20 30 40 50 60 pF1KE2 MSDSGSQLGSMGSLTMKSQLQITVISAKLKENKKNWFGPSPYVEVTVDGQSKKTEKCNNT ::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MSDSGSQLGSMGSLTMKSQLQITVISAKLKENKKNWFGPSPYVEVTVDGQSKKTEKCNNT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 NSPKWKQPLTVIVTPVSKLHFRVWSHQTLKSDVLLGTAALDIYETLKSNNMKLEEVVVTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NSPKWKQPLTVIVTPVSKLHFRVWSHQTLKSDVLLGTAALDIYETLKSNNMKLEEVVVTL 70 80 90 100 110 120 130 140 150 pF1KE2 QLGGDKEPTETIGDLSICLDGLQLESEVVTNGETTCSES--------------------- ::::::::::::::::::::::::::::::::::::::. NP_001 QLGGDKEPTETIGDLSICLDGLQLESEVVTNGETTCSENGVSLCLPRLECNSAISAHCNL 130 140 150 160 170 180 160 170 180 190 pF1KE2 --------------------ASQNDDGSRSKDETRVSTNGSDDPEDAGAGENRRVSGNNS :::::::::::::::::::::::::::::::::::::::: NP_001 CLPGLSDSPISASRVAGFTGASQNDDGSRSKDETRVSTNGSDDPEDAGAGENRRVSGNNS 190 200 210 220 230 240 200 210 220 230 240 250 pF1KE2 PSLSNGGFKPSRPPRPSRPPPPTPRRPASVNGSPSATSESDGSSTGSLPPTNTNTNTSEG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PSLSNGGFKPSRPPRPSRPPPPTPRRPASVNGSPSATSESDGSSTGSLPPTNTNTNTSEG 250 260 270 280 290 300 260 270 280 290 300 310 pF1KE2 ATSGLIIPLTISGGSGPRPLNPVTQAPLPPGWEQRVDQHGRVYYVDHVEKRTTWDRPEPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ATSGLIIPLTISGGSGPRPLNPVTQAPLPPGWEQRVDQHGRVYYVDHVEKRTTWDRPEPL 310 320 330 340 350 360 320 330 340 350 360 370 pF1KE2 PPGWERRVDNMGRIYYVDHFTRTTTWQRPTLESVRNYEQWQLQRSQLQGAMQQFNQRFIY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PPGWERRVDNMGRIYYVDHFTRTTTWQRPTLESVRNYEQWQLQRSQLQGAMQQFNQRFIY 370 380 390 400 410 420 380 390 400 410 420 430 pF1KE2 GNQDLFATSQSKEFDPLGPLPPGWEKRTDSNGRVYFVNHNTRITQWEDPRSQGQLNEKPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GNQDLFATSQSKEFDPLGPLPPGWEKRTDSNGRVYFVNHNTRITQWEDPRSQGQLNEKPL 430 440 450 460 470 480 440 450 460 470 480 490 pF1KE2 PEGWEMRFTVDGIPYFVDHNRRTTTYIDPRTGKSALDNGPQIAYVRDFKAKVQYFRFWCQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PEGWEMRFTVDGIPYFVDHNRRTTTYIDPRTGKSALDNGPQIAYVRDFKAKVQYFRFWCQ 490 500 510 520 530 540 500 510 520 530 540 550 pF1KE2 QLAMPQHIKITVTRKTLFEDSFQQIMSFSPQDLRRRLWVIFPGEEGLDYGGVAREWFFLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QLAMPQHIKITVTRKTLFEDSFQQIMSFSPQDLRRRLWVIFPGEEGLDYGGVAREWFFLL 550 560 570 580 590 600 560 570 580 590 600 610 pF1KE2 SHEVLNPMYCLFEYAGKDNYCLQINPASYINPDHLKYFRFIGRFIAMALFHGKFIDTGFS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SHEVLNPMYCLFEYAGKDNYCLQINPASYINPDHLKYFRFIGRFIAMALFHGKFIDTGFS 610 620 630 640 650 660 620 630 640 650 660 670 pF1KE2 LPFYKRILNKPVGLKDLESIDPEFYNSLIWVKENNIEECDLEMYFSVDKEILGEIKSHDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LPFYKRILNKPVGLKDLESIDPEFYNSLIWVKENNIEECDLEMYFSVDKEILGEIKSHDL 670 680 690 700 710 720 680 690 700 710 720 730 pF1KE2 KPNGGNILVTEENKEEYIRMVAEWRLSRGVEEQTQAFFEGFNEILPQQYLQYFDAKELEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KPNGGNILVTEENKEEYIRMVAEWRLSRGVEEQTQAFFEGFNEILPQQYLQYFDAKELEV 730 740 750 760 770 780 740 750 760 770 780 790 pF1KE2 LLCGMQEIDLNDWQRHAIYRHYARTSKQIMWFWQFVKEIDNEKRMRLLQFVTGTCRLPVG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LLCGMQEIDLNDWQRHAIYRHYARTSKQIMWFWQFVKEIDNEKRMRLLQFVTGTCRLPVG 790 800 810 820 830 840 800 810 820 830 840 850 pF1KE2 GFADLMGSNGPQKFCIEKVGKENWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GFADLMGSNGPQKFCIEKVGKENWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGF 850 860 870 880 890 900 860 pF1KE2 GQE ::: NP_001 GQE >>XP_011527381 (OMIM: 606409,613385) PREDICTED: E3 ubiqu (692 aa) initn: 4825 init1: 4825 opt: 4825 Z-score: 2765.6 bits: 522.5 E(85289): 2.6e-147 Smith-Waterman score: 4825; 99.9% identity (100.0% similar) in 689 aa overlap (174-862:4-692) 150 160 170 180 190 200 pF1KE2 LESEVVTNGETTCSESASQNDDGSRSKDETRVSTNGSDDPEDAGAGENRRVSGNNSPSLS .::::::::::::::::::::::::::::: XP_011 MIYKVSTNGSDDPEDAGAGENRRVSGNNSPSLS 10 20 30 210 220 230 240 250 260 pF1KE2 NGGFKPSRPPRPSRPPPPTPRRPASVNGSPSATSESDGSSTGSLPPTNTNTNTSEGATSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NGGFKPSRPPRPSRPPPPTPRRPASVNGSPSATSESDGSSTGSLPPTNTNTNTSEGATSG 40 50 60 70 80 90 270 280 290 300 310 320 pF1KE2 LIIPLTISGGSGPRPLNPVTQAPLPPGWEQRVDQHGRVYYVDHVEKRTTWDRPEPLPPGW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LIIPLTISGGSGPRPLNPVTQAPLPPGWEQRVDQHGRVYYVDHVEKRTTWDRPEPLPPGW 100 110 120 130 140 150 330 340 350 360 370 380 pF1KE2 ERRVDNMGRIYYVDHFTRTTTWQRPTLESVRNYEQWQLQRSQLQGAMQQFNQRFIYGNQD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ERRVDNMGRIYYVDHFTRTTTWQRPTLESVRNYEQWQLQRSQLQGAMQQFNQRFIYGNQD 160 170 180 190 200 210 390 400 410 420 430 440 pF1KE2 LFATSQSKEFDPLGPLPPGWEKRTDSNGRVYFVNHNTRITQWEDPRSQGQLNEKPLPEGW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LFATSQSKEFDPLGPLPPGWEKRTDSNGRVYFVNHNTRITQWEDPRSQGQLNEKPLPEGW 220 230 240 250 260 270 450 460 470 480 490 500 pF1KE2 EMRFTVDGIPYFVDHNRRTTTYIDPRTGKSALDNGPQIAYVRDFKAKVQYFRFWCQQLAM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EMRFTVDGIPYFVDHNRRTTTYIDPRTGKSALDNGPQIAYVRDFKAKVQYFRFWCQQLAM 280 290 300 310 320 330 510 520 530 540 550 560 pF1KE2 PQHIKITVTRKTLFEDSFQQIMSFSPQDLRRRLWVIFPGEEGLDYGGVAREWFFLLSHEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PQHIKITVTRKTLFEDSFQQIMSFSPQDLRRRLWVIFPGEEGLDYGGVAREWFFLLSHEV 340 350 360 370 380 390 570 580 590 600 610 620 pF1KE2 LNPMYCLFEYAGKDNYCLQINPASYINPDHLKYFRFIGRFIAMALFHGKFIDTGFSLPFY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LNPMYCLFEYAGKDNYCLQINPASYINPDHLKYFRFIGRFIAMALFHGKFIDTGFSLPFY 400 410 420 430 440 450 630 640 650 660 670 680 pF1KE2 KRILNKPVGLKDLESIDPEFYNSLIWVKENNIEECDLEMYFSVDKEILGEIKSHDLKPNG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KRILNKPVGLKDLESIDPEFYNSLIWVKENNIEECDLEMYFSVDKEILGEIKSHDLKPNG 460 470 480 490 500 510 690 700 710 720 730 740 pF1KE2 GNILVTEENKEEYIRMVAEWRLSRGVEEQTQAFFEGFNEILPQQYLQYFDAKELEVLLCG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GNILVTEENKEEYIRMVAEWRLSRGVEEQTQAFFEGFNEILPQQYLQYFDAKELEVLLCG 520 530 540 550 560 570 750 760 770 780 790 800 pF1KE2 MQEIDLNDWQRHAIYRHYARTSKQIMWFWQFVKEIDNEKRMRLLQFVTGTCRLPVGGFAD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MQEIDLNDWQRHAIYRHYARTSKQIMWFWQFVKEIDNEKRMRLLQFVTGTCRLPVGGFAD 580 590 600 610 620 630 810 820 830 840 850 860 pF1KE2 LMGSNGPQKFCIEKVGKENWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGFGQE ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LMGSNGPQKFCIEKVGKENWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGFGQE 640 650 660 670 680 690 >>XP_005260627 (OMIM: 606409,613385) PREDICTED: E3 ubiqu (692 aa) initn: 4825 init1: 4825 opt: 4825 Z-score: 2765.6 bits: 522.5 E(85289): 2.6e-147 Smith-Waterman score: 4825; 99.9% identity (100.0% similar) in 689 aa overlap (174-862:4-692) 150 160 170 180 190 200 pF1KE2 LESEVVTNGETTCSESASQNDDGSRSKDETRVSTNGSDDPEDAGAGENRRVSGNNSPSLS .::::::::::::::::::::::::::::: XP_005 MFRKVSTNGSDDPEDAGAGENRRVSGNNSPSLS 10 20 30 210 220 230 240 250 260 pF1KE2 NGGFKPSRPPRPSRPPPPTPRRPASVNGSPSATSESDGSSTGSLPPTNTNTNTSEGATSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 NGGFKPSRPPRPSRPPPPTPRRPASVNGSPSATSESDGSSTGSLPPTNTNTNTSEGATSG 40 50 60 70 80 90 270 280 290 300 310 320 pF1KE2 LIIPLTISGGSGPRPLNPVTQAPLPPGWEQRVDQHGRVYYVDHVEKRTTWDRPEPLPPGW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LIIPLTISGGSGPRPLNPVTQAPLPPGWEQRVDQHGRVYYVDHVEKRTTWDRPEPLPPGW 100 110 120 130 140 150 330 340 350 360 370 380 pF1KE2 ERRVDNMGRIYYVDHFTRTTTWQRPTLESVRNYEQWQLQRSQLQGAMQQFNQRFIYGNQD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ERRVDNMGRIYYVDHFTRTTTWQRPTLESVRNYEQWQLQRSQLQGAMQQFNQRFIYGNQD 160 170 180 190 200 210 390 400 410 420 430 440 pF1KE2 LFATSQSKEFDPLGPLPPGWEKRTDSNGRVYFVNHNTRITQWEDPRSQGQLNEKPLPEGW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LFATSQSKEFDPLGPLPPGWEKRTDSNGRVYFVNHNTRITQWEDPRSQGQLNEKPLPEGW 220 230 240 250 260 270 450 460 470 480 490 500 pF1KE2 EMRFTVDGIPYFVDHNRRTTTYIDPRTGKSALDNGPQIAYVRDFKAKVQYFRFWCQQLAM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EMRFTVDGIPYFVDHNRRTTTYIDPRTGKSALDNGPQIAYVRDFKAKVQYFRFWCQQLAM 280 290 300 310 320 330 510 520 530 540 550 560 pF1KE2 PQHIKITVTRKTLFEDSFQQIMSFSPQDLRRRLWVIFPGEEGLDYGGVAREWFFLLSHEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PQHIKITVTRKTLFEDSFQQIMSFSPQDLRRRLWVIFPGEEGLDYGGVAREWFFLLSHEV 340 350 360 370 380 390 570 580 590 600 610 620 pF1KE2 LNPMYCLFEYAGKDNYCLQINPASYINPDHLKYFRFIGRFIAMALFHGKFIDTGFSLPFY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LNPMYCLFEYAGKDNYCLQINPASYINPDHLKYFRFIGRFIAMALFHGKFIDTGFSLPFY 400 410 420 430 440 450 630 640 650 660 670 680 pF1KE2 KRILNKPVGLKDLESIDPEFYNSLIWVKENNIEECDLEMYFSVDKEILGEIKSHDLKPNG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KRILNKPVGLKDLESIDPEFYNSLIWVKENNIEECDLEMYFSVDKEILGEIKSHDLKPNG 460 470 480 490 500 510 690 700 710 720 730 740 pF1KE2 GNILVTEENKEEYIRMVAEWRLSRGVEEQTQAFFEGFNEILPQQYLQYFDAKELEVLLCG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GNILVTEENKEEYIRMVAEWRLSRGVEEQTQAFFEGFNEILPQQYLQYFDAKELEVLLCG 520 530 540 550 560 570 750 760 770 780 790 800 pF1KE2 MQEIDLNDWQRHAIYRHYARTSKQIMWFWQFVKEIDNEKRMRLLQFVTGTCRLPVGGFAD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MQEIDLNDWQRHAIYRHYARTSKQIMWFWQFVKEIDNEKRMRLLQFVTGTCRLPVGGFAD 580 590 600 610 620 630 810 820 830 840 850 860 pF1KE2 LMGSNGPQKFCIEKVGKENWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGFGQE ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LMGSNGPQKFCIEKVGKENWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGFGQE 640 650 660 670 680 690 862 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 20:42:03 2016 done: Sun Nov 6 20:42:05 2016 Total Scan time: 14.990 Total Display time: 0.310 Function used was FASTA [36.3.4 Apr, 2011]