FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE1906, 442 aa 1>>>pF1KE1906 442 - 442 aa - 442 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.2229+/-0.000324; mu= 18.9780+/- 0.020 mean_var=73.6160+/-14.572, 0's: 0 Z-trim(115.8): 71 B-trim: 41 in 1/55 Lambda= 0.149482 statistics sampled from 26378 (26450) to 26378 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.683), E-opt: 0.2 (0.31), width: 16 Scan time: 7.950 The best scores are: opt bits E(85289) NP_001129071 (OMIM: 190220,614816) transforming gr ( 442) 3006 657.4 2.1e-188 NP_003229 (OMIM: 190220,614816) transforming growt ( 414) 2052 451.7 1.7e-126 NP_003230 (OMIM: 107970,190230,615582) transformin ( 412) 1232 274.8 2.9e-73 NP_001316868 (OMIM: 107970,190230,615582) transfor ( 412) 1232 274.8 2.9e-73 NP_000651 (OMIM: 131300,190180,219700) transformin ( 390) 699 159.8 1.1e-38 XP_011525544 (OMIM: 131300,190180,219700) PREDICTE ( 391) 692 158.3 3.2e-38 NP_001316867 (OMIM: 107970,190230,615582) transfor ( 309) 592 136.7 8.2e-32 XP_006719257 (OMIM: 603936) PREDICTED: growth/diff ( 407) 302 74.2 6.8e-13 NP_005802 (OMIM: 603936) growth/differentiation fa ( 407) 302 74.2 6.8e-13 NP_005250 (OMIM: 601788,614160) growth/differentia ( 375) 298 73.4 1.2e-12 XP_016867665 (OMIM: 147290) PREDICTED: inhibin bet ( 426) 297 73.2 1.5e-12 NP_002183 (OMIM: 147290) inhibin beta A chain prep ( 426) 297 73.2 1.5e-12 XP_016867664 (OMIM: 147290) PREDICTED: inhibin bet ( 483) 297 73.2 1.7e-12 XP_016867663 (OMIM: 147290) PREDICTED: inhibin bet ( 548) 297 73.3 1.8e-12 NP_001709 (OMIM: 112266) bone morphogenetic protei ( 513) 275 68.5 4.6e-11 NP_113667 (OMIM: 612031) inhibin beta E chain prep ( 350) 271 67.5 6.3e-11 NP_001710 (OMIM: 112267) bone morphogenetic protei ( 431) 266 66.5 1.6e-10 NP_001001557 (OMIM: 118100,601147,613094,613703,61 ( 455) 253 63.7 1.1e-09 NP_001306067 (OMIM: 112600,113100,200700,201250,22 ( 501) 253 63.7 1.2e-09 NP_000548 (OMIM: 112600,113100,200700,201250,22890 ( 501) 253 63.7 1.2e-09 XP_011527377 (OMIM: 112600,113100,200700,201250,22 ( 501) 253 63.7 1.2e-09 XP_016866687 (OMIM: 112265) PREDICTED: bone morpho ( 239) 247 62.2 1.7e-09 XP_011527625 (OMIM: 112261,112600,235200) PREDICTE ( 240) 246 62.0 2e-09 NP_878248 (OMIM: 604651) growth/differentiation fa ( 450) 249 62.8 2e-09 NP_066551 (OMIM: 112265) bone morphogenetic protei ( 454) 247 62.4 2.8e-09 NP_001191 (OMIM: 112261,112600,235200) bone morpho ( 396) 246 62.2 2.9e-09 NP_055297 (OMIM: 608748) bone morphogenetic protei ( 424) 246 62.2 3.1e-09 NP_005529 (OMIM: 601233) inhibin beta C chain prep ( 352) 242 61.3 4.8e-09 NP_002184 (OMIM: 147390) inhibin beta B chain prep ( 407) 238 60.4 9.8e-09 NP_004855 (OMIM: 605312) growth/differentiation fa ( 308) 235 59.7 1.2e-08 XP_016877093 (OMIM: 112262,600625,607932) PREDICTE ( 345) 235 59.7 1.3e-08 XP_016877094 (OMIM: 112262,600625,607932) PREDICTE ( 345) 235 59.7 1.3e-08 NP_570911 (OMIM: 112262,600625,607932) bone morpho ( 408) 235 59.8 1.5e-08 NP_001193 (OMIM: 112262,600625,607932) bone morpho ( 408) 235 59.8 1.5e-08 XP_005268072 (OMIM: 112262,600625,607932) PREDICTE ( 408) 235 59.8 1.5e-08 XP_016877092 (OMIM: 112262,600625,607932) PREDICTE ( 408) 235 59.8 1.5e-08 NP_065685 (OMIM: 606522,613702,613703,613704) grow ( 364) 228 58.3 4e-08 NP_001483 (OMIM: 187500,208530,217095,602880,61385 ( 372) 224 57.4 7.4e-08 NP_001192 (OMIM: 112263) bone morphogenetic protei ( 472) 217 56.0 2.5e-07 NP_001316835 (OMIM: 270100,601265) nodal homolog i ( 214) 198 51.6 2.3e-06 NP_060525 (OMIM: 270100,601265) nodal homolog isof ( 347) 198 51.8 3.4e-06 NP_004953 (OMIM: 601361) growth/differentiation fa ( 478) 192 50.6 1.1e-05 NP_057288 (OMIM: 605120,615506) growth/differentia ( 429) 189 49.9 1.5e-05 NP_005439 (OMIM: 300247,300510) bone morphogenetic ( 392) 184 48.8 3e-05 XP_011540327 (OMIM: 602284) PREDICTED: bone morpho ( 230) 148 40.9 0.0044 XP_005271206 (OMIM: 602284) PREDICTED: bone morpho ( 231) 148 40.9 0.0044 XP_016857645 (OMIM: 602284) PREDICTED: bone morpho ( 236) 148 40.9 0.0044 XP_011540324 (OMIM: 602284) PREDICTED: bone morpho ( 357) 148 41.0 0.0061 XP_016857644 (OMIM: 602284) PREDICTED: bone morpho ( 382) 148 41.0 0.0065 NP_001711 (OMIM: 602284) bone morphogenetic protei ( 402) 148 41.0 0.0067 >>NP_001129071 (OMIM: 190220,614816) transforming growth (442 aa) initn: 3006 init1: 3006 opt: 3006 Z-score: 3503.4 bits: 657.4 E(85289): 2.1e-188 Smith-Waterman score: 3006; 100.0% identity (100.0% similar) in 442 aa overlap (1-442:1-442) 10 20 30 40 50 60 pF1KE1 MHYCVLSAFLILHLVTVALSLSTCSTLDMDQFMRKRIEAIRGQILSKLKLTSPPEDYPEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MHYCVLSAFLILHLVTVALSLSTCSTLDMDQFMRKRIEAIRGQILSKLKLTSPPEDYPEP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 EEVPPEVISIYNSTRDLLQEKASRRAAACERERSDEEYYAKEVYKIDMPPFFPSETVCPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EEVPPEVISIYNSTRDLLQEKASRRAAACERERSDEEYYAKEVYKIDMPPFFPSETVCPV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 VTTPSGSVGSLCSRQSQVLCGYLDAIPPTFYRPYFRIVRFDVSAMEKNASNLVKAEFRVF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VTTPSGSVGSLCSRQSQVLCGYLDAIPPTFYRPYFRIVRFDVSAMEKNASNLVKAEFRVF 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 RLQNPKARVPEQRIELYQILKSKDLTSPTQRYIDSKVVKTRAEGEWLSFDVTDAVHEWLH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RLQNPKARVPEQRIELYQILKSKDLTSPTQRYIDSKVVKTRAEGEWLSFDVTDAVHEWLH 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE1 HKDRNLGFKISLHCPCCTFVPSNNYIIPNKSEELEARFAGIDGTSTYTSGDQKTIKSTRK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HKDRNLGFKISLHCPCCTFVPSNNYIIPNKSEELEARFAGIDGTSTYTSGDQKTIKSTRK 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE1 KNSGKTPHLLLMLLPSYRLESQQTNRRKKRALDAAYCFRNVQDNCCLRPLYIDFKRDLGW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KNSGKTPHLLLMLLPSYRLESQQTNRRKKRALDAAYCFRNVQDNCCLRPLYIDFKRDLGW 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE1 KWIHEPKGYNANFCAGACPYLWSSDTQHSRVLSLYNTINPEASASPCCVSQDLEPLTILY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KWIHEPKGYNANFCAGACPYLWSSDTQHSRVLSLYNTINPEASASPCCVSQDLEPLTILY 370 380 390 400 410 420 430 440 pF1KE1 YIGKTPKIEQLSNMIVKSCKCS :::::::::::::::::::::: NP_001 YIGKTPKIEQLSNMIVKSCKCS 430 440 >>NP_003229 (OMIM: 190220,614816) transforming growth fa (414 aa) initn: 2052 init1: 2052 opt: 2052 Z-score: 2391.9 bits: 451.7 E(85289): 1.7e-126 Smith-Waterman score: 2742; 93.4% identity (93.7% similar) in 442 aa overlap (1-442:1-414) 10 20 30 40 50 60 pF1KE1 MHYCVLSAFLILHLVTVALSLSTCSTLDMDQFMRKRIEAIRGQILSKLKLTSPPEDYPEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 MHYCVLSAFLILHLVTVALSLSTCSTLDMDQFMRKRIEAIRGQILSKLKLTSPPEDYPEP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 EEVPPEVISIYNSTRDLLQEKASRRAAACERERSDEEYYAKEVYKIDMPPFFPSETVCPV ::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 EEVPPEVISIYNSTRDLLQEKASRRAAACERERSDEEYYAKEVYKIDMPPFFPSE----- 70 80 90 100 110 130 140 150 160 170 180 pF1KE1 VTTPSGSVGSLCSRQSQVLCGYLDAIPPTFYRPYFRIVRFDVSAMEKNASNLVKAEFRVF .:::::::::::::::::::::::::::::::::::: NP_003 -----------------------NAIPPTFYRPYFRIVRFDVSAMEKNASNLVKAEFRVF 120 130 140 150 190 200 210 220 230 240 pF1KE1 RLQNPKARVPEQRIELYQILKSKDLTSPTQRYIDSKVVKTRAEGEWLSFDVTDAVHEWLH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 RLQNPKARVPEQRIELYQILKSKDLTSPTQRYIDSKVVKTRAEGEWLSFDVTDAVHEWLH 160 170 180 190 200 210 250 260 270 280 290 300 pF1KE1 HKDRNLGFKISLHCPCCTFVPSNNYIIPNKSEELEARFAGIDGTSTYTSGDQKTIKSTRK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 HKDRNLGFKISLHCPCCTFVPSNNYIIPNKSEELEARFAGIDGTSTYTSGDQKTIKSTRK 220 230 240 250 260 270 310 320 330 340 350 360 pF1KE1 KNSGKTPHLLLMLLPSYRLESQQTNRRKKRALDAAYCFRNVQDNCCLRPLYIDFKRDLGW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 KNSGKTPHLLLMLLPSYRLESQQTNRRKKRALDAAYCFRNVQDNCCLRPLYIDFKRDLGW 280 290 300 310 320 330 370 380 390 400 410 420 pF1KE1 KWIHEPKGYNANFCAGACPYLWSSDTQHSRVLSLYNTINPEASASPCCVSQDLEPLTILY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 KWIHEPKGYNANFCAGACPYLWSSDTQHSRVLSLYNTINPEASASPCCVSQDLEPLTILY 340 350 360 370 380 390 430 440 pF1KE1 YIGKTPKIEQLSNMIVKSCKCS :::::::::::::::::::::: NP_003 YIGKTPKIEQLSNMIVKSCKCS 400 410 >>NP_003230 (OMIM: 107970,190230,615582) transforming gr (412 aa) initn: 1535 init1: 725 opt: 1232 Z-score: 1436.3 bits: 274.8 E(85289): 2.9e-73 Smith-Waterman score: 1516; 52.7% identity (75.2% similar) in 444 aa overlap (1-442:3-412) 10 20 30 40 50 pF1KE1 MHYC-VLSAFLILHLVTVALSLSTCSTLDMDQFMRKRIEAIRGQILSKLKLTSPPEDY :: .: .. .:...::.::::::.:::. .. .::.:::::::::::.:::::: NP_003 MKMHLQRALVVLALLNFATVSLSLSTCTTLDFGHIKKKRVEAIRGQILSKLRLTSPPEPT 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE1 PEPEEVPPEVISIYNSTRDLLQEKASRRAAACERERSDEEYYAKEVYKIDMPPFFPSETV . :: .:...:::::.::.: ..: .: .: .. ::::::..:.:: NP_003 VMTH-VPYQVLALYNSTRELLEEMHGEREEGCTQENTESEYYAKEIHKFDM--------- 70 80 90 100 110 120 130 140 150 160 170 pF1KE1 CPVVTTPSGSVGSLCSRQSQVLCGYLDAIPPTFYRPYFRIVRFDVSAMEKNASNLVKAEF . .: .. ..: : . :: :.::..::: .:: .::: NP_003 ----------IQGLAEHNELAVC------PKGITSKVFR---FNVSSVEKNRTNLFRAEF 120 130 140 150 180 190 200 210 220 230 pF1KE1 RVFRLQNPKARVPEQRIELYQILKSKDLTSPTQRYIDSKVVKTRAEGEWLSFDVTDAVHE ::.:. ::... ::::::.:::. : :::: .: . ::. .:::::::::.:.: NP_003 RVLRVPNPSSKRNEQRIELFQILRP-DEHIAKQRYIGGKNLPTRGTAEWLSFDVTDTVRE 160 170 180 190 200 210 240 250 260 270 280 290 pF1KE1 WLHHKDRNLGFKISLHCPCCTFVPSNNYIIPNKSEELEARFAGIDGTSTYTSGDQKTIKS :: ... :::..::.:::: :: : :. :. : : .: .: :.:. . . :: .: NP_003 WLLRRESNLGLEISIHCPCHTFQP-NGDILENIHEVMEIKFKGVDNEDDHGRGDLGRLK- 220 230 240 250 260 300 310 320 330 340 350 pF1KE1 TRKKNSGKTPHLLLMLLPSYRLESQ-QTNRRKKRALDAAYCFRNVQDNCCLRPLYIDFKR :... ..:::.::..: .::.. : ..:::::::. :::::...:::.:::::::.. NP_003 --KQKDHHNPHLILMMIPPHRLDNPGQGGQRKKRALDTNYCFRNLEENCCVRPLYIDFRQ 270 280 290 300 310 320 360 370 380 390 400 410 pF1KE1 DLGWKWIHEPKGYNANFCAGACPYLWSSDTQHSRVLSLYNTINPEASASPCCVSQDLEPL ::::::.:::::: ::::.: :::: :.:: :: ::.::::.::::::::::: :::::: NP_003 DLGWKWVHEPKGYYANFCSGPCPYLRSADTTHSTVLGLYNTLNPEASASPCCVPQDLEPL 330 340 350 360 370 380 420 430 440 pF1KE1 TILYYIGKTPKIEQLSNMIVKSCKCS :::::.:.:::.::::::.::::::: NP_003 TILYYVGRTPKVEQLSNMVVKSCKCS 390 400 410 >>NP_001316868 (OMIM: 107970,190230,615582) transforming (412 aa) initn: 1535 init1: 725 opt: 1232 Z-score: 1436.3 bits: 274.8 E(85289): 2.9e-73 Smith-Waterman score: 1516; 52.7% identity (75.2% similar) in 444 aa overlap (1-442:3-412) 10 20 30 40 50 pF1KE1 MHYC-VLSAFLILHLVTVALSLSTCSTLDMDQFMRKRIEAIRGQILSKLKLTSPPEDY :: .: .. .:...::.::::::.:::. .. .::.:::::::::::.:::::: NP_001 MKMHLQRALVVLALLNFATVSLSLSTCTTLDFGHIKKKRVEAIRGQILSKLRLTSPPEPT 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE1 PEPEEVPPEVISIYNSTRDLLQEKASRRAAACERERSDEEYYAKEVYKIDMPPFFPSETV . :: .:...:::::.::.: ..: .: .: .. ::::::..:.:: NP_001 VMTH-VPYQVLALYNSTRELLEEMHGEREEGCTQENTESEYYAKEIHKFDM--------- 70 80 90 100 110 120 130 140 150 160 170 pF1KE1 CPVVTTPSGSVGSLCSRQSQVLCGYLDAIPPTFYRPYFRIVRFDVSAMEKNASNLVKAEF . .: .. ..: : . :: :.::..::: .:: .::: NP_001 ----------IQGLAEHNELAVC------PKGITSKVFR---FNVSSVEKNRTNLFRAEF 120 130 140 150 180 190 200 210 220 230 pF1KE1 RVFRLQNPKARVPEQRIELYQILKSKDLTSPTQRYIDSKVVKTRAEGEWLSFDVTDAVHE ::.:. ::... ::::::.:::. : :::: .: . ::. .:::::::::.:.: NP_001 RVLRVPNPSSKRNEQRIELFQILRP-DEHIAKQRYIGGKNLPTRGTAEWLSFDVTDTVRE 160 170 180 190 200 210 240 250 260 270 280 290 pF1KE1 WLHHKDRNLGFKISLHCPCCTFVPSNNYIIPNKSEELEARFAGIDGTSTYTSGDQKTIKS :: ... :::..::.:::: :: : :. :. : : .: .: :.:. . . :: .: NP_001 WLLRRESNLGLEISIHCPCHTFQP-NGDILENIHEVMEIKFKGVDNEDDHGRGDLGRLK- 220 230 240 250 260 300 310 320 330 340 350 pF1KE1 TRKKNSGKTPHLLLMLLPSYRLESQ-QTNRRKKRALDAAYCFRNVQDNCCLRPLYIDFKR :... ..:::.::..: .::.. : ..:::::::. :::::...:::.:::::::.. NP_001 --KQKDHHNPHLILMMIPPHRLDNPGQGGQRKKRALDTNYCFRNLEENCCVRPLYIDFRQ 270 280 290 300 310 320 360 370 380 390 400 410 pF1KE1 DLGWKWIHEPKGYNANFCAGACPYLWSSDTQHSRVLSLYNTINPEASASPCCVSQDLEPL ::::::.:::::: ::::.: :::: :.:: :: ::.::::.::::::::::: :::::: NP_001 DLGWKWVHEPKGYYANFCSGPCPYLRSADTTHSTVLGLYNTLNPEASASPCCVPQDLEPL 330 340 350 360 370 380 420 430 440 pF1KE1 TILYYIGKTPKIEQLSNMIVKSCKCS :::::.:.:::.::::::.::::::: NP_001 TILYYVGRTPKVEQLSNMVVKSCKCS 390 400 410 >>NP_000651 (OMIM: 131300,190180,219700) transforming gr (390 aa) initn: 1016 init1: 653 opt: 699 Z-score: 815.4 bits: 159.8 E(85289): 1.1e-38 Smith-Waterman score: 1029; 42.8% identity (63.6% similar) in 439 aa overlap (9-442:18-390) 10 20 30 40 50 pF1KE1 MHYCVLSAFLILHLVTVALSLSTCSTLDMDQFMRKRIEAIRGQILSKLKLT .:.: : .::::.:.::. :::::::::::::::.:. NP_000 MPPSGLRLLPLLLPLLWLLVLTPGRPAAGLSTCKTIDMELVKRKRIEAIRGQILSKLRLA 10 20 30 40 50 60 60 70 80 90 100 pF1KE1 SPPE--DYPEPEEVPPEVISIYNSTRDLLQEKASRRAAACERERSDEEYYAKEVYKIDMP ::: . : : .: :...:::::: ... ..: : : . .:::::: .. : NP_000 SPPSQGEVP-PGPLPEAVLALYNSTRD----RVAGESAEPEPE-PEADYYAKEVTRVLM- 70 80 90 100 110 110 120 130 140 150 160 pF1KE1 PFFPSETVCPVVTTPSGSVGSLCSRQSQVLCGYLDAIPPTFYRPYFRIVRFDVSAMEKNA :: . . :. :. :. : :..: ... . NP_000 ----VETHNEIYDKFKQSTHSI----------YM------F---------FNTSELREAV 120 130 140 170 180 190 200 210 220 pF1KE1 SN---LVKAEFRVFRLQNPKARVPEQRIELYQILKSKDLTSPTQRYIDSKVVKTRAEGEW . : .::.:..:: : .: ::..:::: .. . ::...... :: NP_000 PEPVLLSRAELRLLRL---KLKV-EQHVELYQ-----KYSNNSWRYLSNRLLAPSDSPEW 150 160 170 180 190 230 240 250 260 270 280 pF1KE1 LSFDVTDAVHEWLHHKDRNLGFKISLHCPCCTFVPSNNYIIPNKSEELEARFAGIDGTST :::::: .:..:: . . ::..: :: : .... :.. :.: .: NP_000 LSFDVTGVVRQWLSRGGEIEGFRLSAHCSC-----------DSRDNTLQV---DINGFTT 200 210 220 230 240 290 300 310 320 330 340 pF1KE1 YTSGDQKTIKSTRKKNSGKTPHLLLMLLPSYRLESQQTNRRKKRALDAAYCFRNVQDNCC :: ::.. . : :::: : : . :..:.. ::::. ::: ... ::: NP_000 GRRGDLATIHGMNR------PFLLLMATPLERAQHLQSSRHR-RALDTNYCFSSTEKNCC 250 260 270 280 290 350 360 370 380 390 400 pF1KE1 LRPLYIDFKRDLGWKWIHEPKGYNANFCAGACPYLWSSDTQHSRVLSLYNTINPEASASP .: :::::..:::::::::::::.:::: : :::.:: :::.:.::.::: :: :::.: NP_000 VRQLYIDFRKDLGWKWIHEPKGYHANFCLGPCPYIWSLDTQYSKVLALYNQHNPGASAAP 300 310 320 330 340 350 410 420 430 440 pF1KE1 CCVSQDLEPLTILYYIGKTPKIEQLSNMIVKSCKCS ::: : :::: :.::.:. ::.::::::::.::::: NP_000 CCVPQALEPLPIVYYVGRKPKVEQLSNMIVRSCKCS 360 370 380 390 >>XP_011525544 (OMIM: 131300,190180,219700) PREDICTED: t (391 aa) initn: 1016 init1: 653 opt: 692 Z-score: 807.2 bits: 158.3 E(85289): 3.2e-38 Smith-Waterman score: 1022; 42.6% identity (63.6% similar) in 439 aa overlap (9-442:18-391) 10 20 30 40 50 pF1KE1 MHYCVLSAFLILHLVTVALSLSTCSTLDMDQFMRKRIEAIRGQILSKLKLT .:.: : .::::.:.::. :::::::::::::::.:. XP_011 MPPSGLRLLPLLLPLLWLLVLTPGRPAAGLSTCKTIDMELVKRKRIEAIRGQILSKLRLA 10 20 30 40 50 60 60 70 80 90 100 pF1KE1 SPPE--DYPEPEEVPPEVISIYNSTRDLLQEKASRRAAACERERSDEEYYAKEVYKIDMP ::: . : : .: :...:::::: ... ..: : : . .:::::: .. : XP_011 SPPSQGEVP-PGPLPEAVLALYNSTRD----RVAGESAEPEPE-PEADYYAKEVTRVLM- 70 80 90 100 110 110 120 130 140 150 160 pF1KE1 PFFPSETVCPVVTTPSGSVGSLCSRQSQVLCGYLDAIPPTFYRPYFRIVRFDVSAMEKNA :: . . :. :. :. : :..: ... . XP_011 ----VETHNEIYDKFKQSTHSI----------YM------F---------FNTSELREAV 120 130 140 170 180 190 200 210 220 pF1KE1 SN---LVKAEFRVFRLQNPKARVPEQRIELYQILKSKDLTSPTQRYIDSKVVKTRAEGEW . : .::.:..:: : .: ::..:::: .. . ::...... :: XP_011 PEPVLLSRAELRLLRL---KLKV-EQHVELYQ-----KYSNNSWRYLSNRLLAPSDSPEW 150 160 170 180 190 230 240 250 260 270 280 pF1KE1 LSFDVTDAVHEWLHHKDRNLGFKISLHCPCCTFVPSNNYIIPNKSEELEARFAGIDGTST :::::: .:..:: . . ::..: :: : .... :.. . . : .: XP_011 LSFDVTGVVRQWLSRGGEIEGFRLSAHCSC-----------DSRDNTLQVDINA--GFTT 200 210 220 230 240 290 300 310 320 330 340 pF1KE1 YTSGDQKTIKSTRKKNSGKTPHLLLMLLPSYRLESQQTNRRKKRALDAAYCFRNVQDNCC :: ::.. . : :::: : : . :..:.. ::::. ::: ... ::: XP_011 GRRGDLATIHGMNR------PFLLLMATPLERAQHLQSSRHR-RALDTNYCFSSTEKNCC 250 260 270 280 290 350 360 370 380 390 400 pF1KE1 LRPLYIDFKRDLGWKWIHEPKGYNANFCAGACPYLWSSDTQHSRVLSLYNTINPEASASP .: :::::..:::::::::::::.:::: : :::.:: :::.:.::.::: :: :::.: XP_011 VRQLYIDFRKDLGWKWIHEPKGYHANFCLGPCPYIWSLDTQYSKVLALYNQHNPGASAAP 300 310 320 330 340 350 410 420 430 440 pF1KE1 CCVSQDLEPLTILYYIGKTPKIEQLSNMIVKSCKCS ::: : :::: :.::.:. ::.::::::::.::::: XP_011 CCVPQALEPLPIVYYVGRKPKVEQLSNMIVRSCKCS 360 370 380 390 >>NP_001316867 (OMIM: 107970,190230,615582) transforming (309 aa) initn: 895 init1: 238 opt: 592 Z-score: 692.1 bits: 136.7 E(85289): 8.2e-32 Smith-Waterman score: 876; 44.7% identity (69.6% similar) in 342 aa overlap (1-339:3-309) 10 20 30 40 50 pF1KE1 MHYC-VLSAFLILHLVTVALSLSTCSTLDMDQFMRKRIEAIRGQILSKLKLTSPPEDY :: .: .. .:...::.::::::.:::. .. .::.:::::::::::.:::::: NP_001 MKMHLQRALVVLALLNFATVSLSLSTCTTLDFGHIKKKRVEAIRGQILSKLRLTSPPE-- 10 20 30 40 50 60 70 80 90 100 110 pF1KE1 PEP-EEVPPEVISIYNSTRDLLQEKASRRAAACERERSDEEYYAKEVYKIDMPPFFPSET : .:: .:...:::::.::.: ..: .: .: .. ::::::..:.:: NP_001 PTVMTHVPYQVLALYNSTRELLEEMHGEREEGCTQENTESEYYAKEIHKFDM-------- 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE1 VCPVVTTPSGSVGSLCSRQSQVLCGYLDAIPPTFYRPYFRIVRFDVSAMEKNASNLVKAE . .: .. ..: : . : ::.::..::: .:: .:: NP_001 -----------IQGLAEHNELAVC------PKGITSKVF---RFNVSSVEKNRTNLFRAE 120 130 140 150 180 190 200 210 220 230 pF1KE1 FRVFRLQNPKARVPEQRIELYQILKSKDLTSPTQRYIDSKVVKTRAEGEWLSFDVTDAVH :::.:. ::... ::::::.:::. : :::: .: . ::. .:::::::::.:. NP_001 FRVLRVPNPSSKRNEQRIELFQILRP-DEHIAKQRYIGGKNLPTRGTAEWLSFDVTDTVR 160 170 180 190 200 240 250 260 270 280 290 pF1KE1 EWLHHKDRNLGFKISLHCPCCTFVPSNNYIIPNKSEELEARFAGIDGTSTYTSGDQKTIK ::: ... :::..::.:::: :: : :. :. : : .: .: :.:. . . :: .: NP_001 EWLLRRESNLGLEISIHCPCHTFQP-NGDILENIHEVMEIKFKGVDNEDDHGRGDLGRLK 210 220 230 240 250 260 300 310 320 330 340 350 pF1KE1 STRKKNSGKTPHLLLMLLPSYRLESQ-QTNRRKKRALDAAYCFRNVQDNCCLRPLYIDFK :... ..:::.::..: .::.. : ..:::::::. :::: NP_001 ---KQKDHHNPHLILMMIPPHRLDNPGQGGQRKKRALDTNYCFR 270 280 290 300 360 370 380 390 400 410 pF1KE1 RDLGWKWIHEPKGYNANFCAGACPYLWSSDTQHSRVLSLYNTINPEASASPCCVSQDLEP >>XP_006719257 (OMIM: 603936) PREDICTED: growth/differen (407 aa) initn: 325 init1: 119 opt: 302 Z-score: 352.4 bits: 74.2 E(85289): 6.8e-13 Smith-Waterman score: 330; 25.4% identity (47.5% similar) in 448 aa overlap (16-442:54-407) 10 20 30 40 pF1KE1 MHYCVLSAFLILHLVTVALSLSTCSTLDMDQFMRK-RIEAIRGQI .:: . : . : :. :.:.:..:: XP_006 AAEGPAAAAAAAAAAAAAGVGGERSSRPAPSVAPEPDGCPVCVWRQHSRELRLESIKSQI 30 40 50 60 70 80 50 60 70 80 90 pF1KE1 LSKLKLTSPPEDYPE------PEEVPP--EVISIYNSTRDLLQEKASRRAAACERERSDE ::::.: :. : :. .:: ....... : :: : .. XP_006 LSKLRLKEAPNISREVVKQLLPK-APPLQQILDLHDFQGDALQP---------EDFLEED 90 100 110 120 130 100 110 120 130 140 150 pF1KE1 EYYAKEVYKIDMPPFFPSETVCPVVTTPSGSVGSLCSRQSQVLCGYLDAIPPTFYRPYFR ::.: :.: .. . :.: : .:: :: : . . : XP_006 EYHATTETVISM-----AQETDPAVQT-DGS--PLC-------CHF-------HFSPK-- 140 150 160 160 170 180 190 200 pF1KE1 IVRFDVSAMEKNASNLVKAEFRVFRLQNPKARVPEQRIELYQILKSKDLTSPT------- : : ....::.. :. : ::. :::. : ::. XP_006 -VMF---------TKVLKAQLWVY--LRP---VPRPATVYLQILRLKPLTGEGTAGGGGG 170 180 190 200 210 210 220 230 240 250 260 pF1KE1 -QRYIDSKVVKTRAE---GEWLSFDVTDAVHEWLHHKDRNLGFKISLHCPCCTFVPSNNY .:.: . .: . . :.: :.: ...: :... . : :..:. .: :: XP_006 GRRHIRIRSLKIELHSRSGHWQSIDFKQVLHSWFRQPQSNWGIEIN------AFDPS--- 220 230 240 250 260 270 280 290 300 310 320 pF1KE1 IIPNKSEELEARFAGIDGTSTYTSGDQKTIKSTRKKNSGKTPHLLLMLLPSYRLESQQTN : . .. : : : . : .: ... XP_006 ------------------------GTDLAVTSLGPGAEGLHPFMELRVL--------ENT 270 280 290 330 340 350 360 370 380 pF1KE1 RRKKRALDAAYCFRNVQDNCCLRPLYIDFKRDLGWKWIHEPKGYNANFCAGACPYLWSSD .:..: : .. .. :: :: .::. .:: :: :: :.::.:.: : :.. . XP_006 KRSRRNLGLDCDEHSSESRCCRYPLTVDFEA-FGWDWIIAPKRYKANYCSGQCEYMFMQK 300 310 320 330 340 350 390 400 410 420 430 440 pF1KE1 TQHSRVLSLYNTINPEASASPCCVSQDLEPLTILYYIGKTPKIE-QLSNMIVKSCKCS :.. : . ::..::.:::. . :...::. : : .. .:.: : :: XP_006 YPHTH---LVQQANPRGSAGPCCTPTKMSPINMLYFNDKQQIIYGKIPGMVVDRCGCS 360 370 380 390 400 >>NP_005802 (OMIM: 603936) growth/differentiation factor (407 aa) initn: 325 init1: 119 opt: 302 Z-score: 352.4 bits: 74.2 E(85289): 6.8e-13 Smith-Waterman score: 330; 25.4% identity (47.5% similar) in 448 aa overlap (16-442:54-407) 10 20 30 40 pF1KE1 MHYCVLSAFLILHLVTVALSLSTCSTLDMDQFMRK-RIEAIRGQI .:: . : . : :. :.:.:..:: NP_005 AAEGPAAAAAAAAAAAAAGVGGERSSRPAPSVAPEPDGCPVCVWRQHSRELRLESIKSQI 30 40 50 60 70 80 50 60 70 80 90 pF1KE1 LSKLKLTSPPEDYPE------PEEVPP--EVISIYNSTRDLLQEKASRRAAACERERSDE ::::.: :. : :. .:: ....... : :: : .. NP_005 LSKLRLKEAPNISREVVKQLLPK-APPLQQILDLHDFQGDALQP---------EDFLEED 90 100 110 120 130 100 110 120 130 140 150 pF1KE1 EYYAKEVYKIDMPPFFPSETVCPVVTTPSGSVGSLCSRQSQVLCGYLDAIPPTFYRPYFR ::.: :.: .. . :.: : .:: :: : . . : NP_005 EYHATTETVISM-----AQETDPAVQT-DGS--PLC-------CHF-------HFSPK-- 140 150 160 160 170 180 190 200 pF1KE1 IVRFDVSAMEKNASNLVKAEFRVFRLQNPKARVPEQRIELYQILKSKDLTSPT------- : : ....::.. :. : ::. :::. : ::. NP_005 -VMF---------TKVLKAQLWVY--LRP---VPRPATVYLQILRLKPLTGEGTAGGGGG 170 180 190 200 210 210 220 230 240 250 260 pF1KE1 -QRYIDSKVVKTRAE---GEWLSFDVTDAVHEWLHHKDRNLGFKISLHCPCCTFVPSNNY .:.: . .: . . :.: :.: ...: :... . : :..:. .: :: NP_005 GRRHIRIRSLKIELHSRSGHWQSIDFKQVLHSWFRQPQSNWGIEIN------AFDPS--- 220 230 240 250 260 270 280 290 300 310 320 pF1KE1 IIPNKSEELEARFAGIDGTSTYTSGDQKTIKSTRKKNSGKTPHLLLMLLPSYRLESQQTN : . .. : : : . : .: ... NP_005 ------------------------GTDLAVTSLGPGAEGLHPFMELRVL--------ENT 270 280 290 330 340 350 360 370 380 pF1KE1 RRKKRALDAAYCFRNVQDNCCLRPLYIDFKRDLGWKWIHEPKGYNANFCAGACPYLWSSD .:..: : .. .. :: :: .::. .:: :: :: :.::.:.: : :.. . NP_005 KRSRRNLGLDCDEHSSESRCCRYPLTVDFEA-FGWDWIIAPKRYKANYCSGQCEYMFMQK 300 310 320 330 340 350 390 400 410 420 430 440 pF1KE1 TQHSRVLSLYNTINPEASASPCCVSQDLEPLTILYYIGKTPKIE-QLSNMIVKSCKCS :.. : . ::..::.:::. . :...::. : : .. .:.: : :: NP_005 YPHTH---LVQQANPRGSAGPCCTPTKMSPINMLYFNDKQQIIYGKIPGMVVDRCGCS 360 370 380 390 400 >>NP_005250 (OMIM: 601788,614160) growth/differentiation (375 aa) initn: 360 init1: 113 opt: 298 Z-score: 348.3 bits: 73.4 E(85289): 1.2e-12 Smith-Waterman score: 339; 23.5% identity (49.6% similar) in 425 aa overlap (24-442:39-375) 10 20 30 40 50 pF1KE1 MHYCVLSAFLILHLVTVALSLSTCSTLDMDQFMRK-RIEAIRGQILSKLKLTS :.. : .. :::::. ::::::.: . NP_005 YIYLFMLIVAGPVDLNENSEQKENVEKEGLCNACTWRQNTKSSRIEAIKIQILSKLRLET 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE1 PPEDYPEPEEVPPEVISIYNSTRDLLQEKASRRAAACERERSDEEYYAKEVYKIDMPPFF :. ..: ... :.:... .: . . :..:.: NP_005 APNI---SKDVIRQLLPKAPPLRELIDQYDVQRDDSSDGSLEDDDYHAT----------- 70 80 90 100 110 120 130 140 150 160 170 pF1KE1 PSETVCPVVTTPSGSVGSLCSRQSQVLCGYLDAIPPTFYRPYFRIVRFDVSAMEKNASNL .:: ..: :. .:. : .:. : . . .... .. NP_005 -TET---IITMPT---------ESDFLM-QVDGKPKCCFFKFSSKIQYN---------KV 120 130 140 150 180 190 200 210 220 pF1KE1 VKAEFRVFRLQNPKARVPEQRIELYQILKS-KDLTSPTQRYIDSKVVKTRAE---GEWLS :::.. .. : ... ...: :: : :: . .: . : : : NP_005 VKAQLWIY--LRPVETPTTVFVQILRLIKPMKDGT----RYTGIRSLKLDMNPGTGIWQS 160 170 180 190 200 230 240 250 260 270 280 pF1KE1 FDVTDAVHEWLHHKDRNLGFKISLHCPCCTFVPSNNYIIPNKSEELEARFAGIDGTSTYT .:: ....::.. . :::..:. . .....: . : : NP_005 IDVKTVLQNWLKQPESNLGIEIK--------------ALDENGHDLAVTFPG-------- 210 220 230 240 290 300 310 320 330 340 pF1KE1 SGDQKTIKSTRKKNSGKTPHLLLMLLPSYRLESQQTNRRKKRALDAAYCFRNVQDNCCLR :.. : .: : ... .: .:..: . ..... :: NP_005 PGED-----------GLNPFL--------EVKVTDTPKRSRRDFGLDCDEHSTESRCCRY 250 260 270 280 350 360 370 380 390 400 pF1KE1 PLYIDFKRDLGWKWIHEPKGYNANFCAGACPYLWSSDTQHSRVLSLYNTINPEASASPCC :: .::. .:: :: :: :.::.:.: : ... . :.. : . ::..::.::: NP_005 PLTVDFEA-FGWDWIIAPKRYKANYCSGECEFVFLQKYPHTH---LVHQANPRGSAGPCC 290 300 310 320 330 340 410 420 430 440 pF1KE1 VSQDLEPLTILYYIGKTPKIE-QLSNMIVKSCKCS . . :...::. :: : .. :.: : :: NP_005 TPTKMSPINMLYFNGKEQIIYGKIPAMVVDRCGCS 350 360 370 442 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 21:11:26 2016 done: Sun Nov 6 21:11:28 2016 Total Scan time: 7.950 Total Display time: 0.060 Function used was FASTA [36.3.4 Apr, 2011]