Result of FASTA (omim) for
pFN21AB5561
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB5561, 497 aa
1>>>pF1KB5561 497 - 497 aa - 497 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 6.9993+/-0.000361; mu= 11.5558+/- 0.023
mean_var=139.6684+/-28.186, 0's: 0 Z-trim(117.7): 42 B-trim: 216 in 1/51
Lambda= 0.108524
statistics sampled from 29912 (29955) to 29912 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.705), E-opt: 0.2 (0.351), width: 16
Scan time: 10.850
The best scores are: opt bits E(85289)
NP_002383 (OMIM: 164785,614401) E3 ubiquitin-prote ( 497) 3326 532.4 1.1e-150
XP_005268929 (OMIM: 164785,614401) PREDICTED: E3 u ( 491) 3288 526.4 7e-149
XP_006719462 (OMIM: 164785,614401) PREDICTED: E3 u ( 430) 2900 465.6 1.2e-130
XP_006719463 (OMIM: 164785,614401) PREDICTED: E3 u ( 390) 2629 423.2 6.8e-118
NP_001138811 (OMIM: 164785,614401) E3 ubiquitin-pr ( 442) 2212 357.9 3.4e-98
NP_001265391 (OMIM: 164785,614401) E3 ubiquitin-pr ( 321) 1853 301.6 2.2e-81
NP_001138809 (OMIM: 164785,614401) E3 ubiquitin-pr ( 444) 1524 250.2 9e-66
NP_001138812 (OMIM: 164785,614401) E3 ubiquitin-pr ( 295) 1373 226.4 8.6e-59
NP_002384 (OMIM: 602704) protein Mdm4 isoform 1 [H ( 490) 886 150.4 1.1e-35
XP_016856800 (OMIM: 602704) PREDICTED: protein Mdm ( 508) 886 150.4 1.2e-35
XP_016856801 (OMIM: 602704) PREDICTED: protein Mdm ( 503) 876 148.8 3.4e-35
NP_001265446 (OMIM: 602704) protein Mdm4 isoform 5 ( 392) 594 104.6 5.5e-22
NP_001265448 (OMIM: 602704) protein Mdm4 isoform 7 ( 267) 487 87.7 4.6e-17
NP_001191100 (OMIM: 602704) protein Mdm4 isoform 2 ( 440) 369 69.4 2.4e-11
XP_016856802 (OMIM: 602704) PREDICTED: protein Mdm ( 458) 369 69.4 2.5e-11
NP_001191101 (OMIM: 602704) protein Mdm4 isoform 3 ( 164) 345 65.3 1.6e-10
NP_001265447 (OMIM: 602704) protein Mdm4 isoform 6 ( 116) 329 62.6 6.8e-10
NP_001265445 (OMIM: 602704) protein Mdm4 isoform 4 ( 140) 323 61.8 1.5e-09
>>NP_002383 (OMIM: 164785,614401) E3 ubiquitin-protein l (497 aa)
initn: 3326 init1: 3326 opt: 3326 Z-score: 2825.9 bits: 532.4 E(85289): 1.1e-150
Smith-Waterman score: 3326; 100.0% identity (100.0% similar) in 497 aa overlap (1-497:1-497)
10 20 30 40 50 60
pF1KB5 MVRSRQMCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 MVRSRQMCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB5 FYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 FYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQE
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB5 SSDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 SSDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDE
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB5 LSGERQRKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 LSGERQRKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGD
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB5 WLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 WLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEED
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB5 PEISLADYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 PEISLADYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAE
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB5 EGFDVPDCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 EGFDVPDCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEF
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB5 EREETQDKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 EREETQDKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKP
430 440 450 460 470 480
490
pF1KB5 CPVCRQPIQMIVLTYFP
:::::::::::::::::
NP_002 CPVCRQPIQMIVLTYFP
490
>>XP_005268929 (OMIM: 164785,614401) PREDICTED: E3 ubiqu (491 aa)
initn: 3288 init1: 3288 opt: 3288 Z-score: 2793.8 bits: 526.4 E(85289): 7e-149
Smith-Waterman score: 3288; 100.0% identity (100.0% similar) in 491 aa overlap (7-497:1-491)
10 20 30 40 50 60
pF1KB5 MVRSRQMCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVL
10 20 30 40 50
70 80 90 100 110 120
pF1KB5 FYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQE
60 70 80 90 100 110
130 140 150 160 170 180
pF1KB5 SSDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SSDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDE
120 130 140 150 160 170
190 200 210 220 230 240
pF1KB5 LSGERQRKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LSGERQRKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGD
180 190 200 210 220 230
250 260 270 280 290 300
pF1KB5 WLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 WLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEED
240 250 260 270 280 290
310 320 330 340 350 360
pF1KB5 PEISLADYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PEISLADYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAE
300 310 320 330 340 350
370 380 390 400 410 420
pF1KB5 EGFDVPDCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EGFDVPDCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEF
360 370 380 390 400 410
430 440 450 460 470 480
pF1KB5 EREETQDKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EREETQDKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKP
420 430 440 450 460 470
490
pF1KB5 CPVCRQPIQMIVLTYFP
:::::::::::::::::
XP_005 CPVCRQPIQMIVLTYFP
480 490
>>XP_006719462 (OMIM: 164785,614401) PREDICTED: E3 ubiqu (430 aa)
initn: 2900 init1: 2900 opt: 2900 Z-score: 2466.3 bits: 465.6 E(85289): 1.2e-130
Smith-Waterman score: 2900; 100.0% identity (100.0% similar) in 430 aa overlap (68-497:1-430)
40 50 60 70 80 90
pF1KB5 PLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSF
::::::::::::::::::::::::::::::
XP_006 MTKRLYDEKQQHIVYCSNDLLGDLFGVPSF
10 20 30
100 110 120 130 140 150
pF1KB5 SVKEHRKIYTMIYRNLVVVNQQESSDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SVKEHRKIYTMIYRNLVVVNQQESSDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSH
40 50 60 70 80 90
160 170 180 190 200 210
pF1KB5 LVSRPSTSSRRRAISETEENSDELSGERQRKRHKSDSISLSFDESLALCVIREICCERSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LVSRPSTSSRRRAISETEENSDELSGERQRKRHKSDSISLSFDESLALCVIREICCERSS
100 110 120 130 140 150
220 230 240 250 260 270
pF1KB5 SSESTGTPSNPDLDAGVSEHSGDWLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SSESTGTPSNPDLDAGVSEHSGDWLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDE
160 170 180 190 200 210
280 290 300 310 320 330
pF1KB5 DDEVYQVTVYQAGESDTDSFEEDPEISLADYWKCTSCNEMNPPLPSHCNRCWALRENWLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 DDEVYQVTVYQAGESDTDSFEEDPEISLADYWKCTSCNEMNPPLPSHCNRCWALRENWLP
220 230 240 250 260 270
340 350 360 370 380 390
pF1KB5 EDKGKDKGEISEKAKLENSTQAEEGFDVPDCKKTIVNDSRESCVEENDDKITQASQSQES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EDKGKDKGEISEKAKLENSTQAEEGFDVPDCKKTIVNDSRESCVEENDDKITQASQSQES
280 290 300 310 320 330
400 410 420 430 440 450
pF1KB5 EDYSQPSTSSSIIYSSQEDVKEFEREETQDKEESVESSLPLNAIEPCVICQGRPKNGCIV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EDYSQPSTSSSIIYSSQEDVKEFEREETQDKEESVESSLPLNAIEPCVICQGRPKNGCIV
340 350 360 370 380 390
460 470 480 490
pF1KB5 HGKTGHLMACFTCAKKLKKRNKPCPVCRQPIQMIVLTYFP
::::::::::::::::::::::::::::::::::::::::
XP_006 HGKTGHLMACFTCAKKLKKRNKPCPVCRQPIQMIVLTYFP
400 410 420 430
>>XP_006719463 (OMIM: 164785,614401) PREDICTED: E3 ubiqu (390 aa)
initn: 2629 init1: 2629 opt: 2629 Z-score: 2237.6 bits: 423.2 E(85289): 6.8e-118
Smith-Waterman score: 2629; 100.0% identity (100.0% similar) in 390 aa overlap (108-497:1-390)
80 90 100 110 120 130
pF1KB5 QHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGTSVSENRCHLEG
::::::::::::::::::::::::::::::
XP_006 MIYRNLVVVNQQESSDSGTSVSENRCHLEG
10 20 30
140 150 160 170 180 190
pF1KB5 GSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQRKRHKSDSISL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQRKRHKSDSISL
40 50 60 70 80 90
200 210 220 230 240 250
pF1KB5 SFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGDWLDQDSVSDQFSVEFEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGDWLDQDSVSDQFSVEFEV
100 110 120 130 140 150
260 270 280 290 300 310
pF1KB5 ESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLADYWKCTSCNEM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLADYWKCTSCNEM
160 170 180 190 200 210
320 330 340 350 360 370
pF1KB5 NPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVPDCKKTIVNDSR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 NPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVPDCKKTIVNDSR
220 230 240 250 260 270
380 390 400 410 420 430
pF1KB5 ESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQDKEESVESSLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQDKEESVESSLP
280 290 300 310 320 330
440 450 460 470 480 490
pF1KB5 LNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVCRQPIQMIVLTYFP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVCRQPIQMIVLTYFP
340 350 360 370 380 390
>>NP_001138811 (OMIM: 164785,614401) E3 ubiquitin-protei (442 aa)
initn: 2212 init1: 2212 opt: 2212 Z-score: 1884.0 bits: 357.9 E(85289): 3.4e-98
Smith-Waterman score: 2858; 88.9% identity (88.9% similar) in 497 aa overlap (1-497:1-442)
10 20 30 40 50 60
pF1KB5 MVRSRQMCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MVRSRQMCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB5 FYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQE
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB5 SSDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDE
:::::
NP_001 -------------------------------------------------------ENSDE
190 200 210 220 230 240
pF1KB5 LSGERQRKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LSGERQRKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGD
130 140 150 160 170 180
250 260 270 280 290 300
pF1KB5 WLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 WLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEED
190 200 210 220 230 240
310 320 330 340 350 360
pF1KB5 PEISLADYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PEISLADYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAE
250 260 270 280 290 300
370 380 390 400 410 420
pF1KB5 EGFDVPDCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EGFDVPDCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEF
310 320 330 340 350 360
430 440 450 460 470 480
pF1KB5 EREETQDKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EREETQDKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKP
370 380 390 400 410 420
490
pF1KB5 CPVCRQPIQMIVLTYFP
:::::::::::::::::
NP_001 CPVCRQPIQMIVLTYFP
430 440
>>NP_001265391 (OMIM: 164785,614401) E3 ubiquitin-protei (321 aa)
initn: 1853 init1: 1853 opt: 1853 Z-score: 1582.1 bits: 301.6 E(85289): 2.2e-81
Smith-Waterman score: 1853; 100.0% identity (100.0% similar) in 269 aa overlap (229-497:53-321)
200 210 220 230 240 250
pF1KB5 FDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGDWLDQDSVSDQFSVEFEVE
::::::::::::::::::::::::::::::
NP_001 EQETLVRPKPLLLKLLKSVGAQKDTYTMKEDLDAGVSEHSGDWLDQDSVSDQFSVEFEVE
30 40 50 60 70 80
260 270 280 290 300 310
pF1KB5 SLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLADYWKCTSCNEMN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLADYWKCTSCNEMN
90 100 110 120 130 140
320 330 340 350 360 370
pF1KB5 PPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVPDCKKTIVNDSRE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVPDCKKTIVNDSRE
150 160 170 180 190 200
380 390 400 410 420 430
pF1KB5 SCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQDKEESVESSLPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQDKEESVESSLPL
210 220 230 240 250 260
440 450 460 470 480 490
pF1KB5 NAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVCRQPIQMIVLTYFP
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVCRQPIQMIVLTYFP
270 280 290 300 310 320
>--
initn: 329 init1: 329 opt: 329 Z-score: 292.6 bits: 63.0 E(85289): 1.5e-09
Smith-Waterman score: 329; 100.0% identity (100.0% similar) in 52 aa overlap (7-58:1-52)
10 20 30 40 50 60
pF1KB5 MVRSRQMCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVL
::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEDL
10 20 30 40 50
70 80 90 100 110 120
pF1KB5 FYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQE
NP_001 DAGVSEHSGDWLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAG
60 70 80 90 100 110
>>NP_001138809 (OMIM: 164785,614401) E3 ubiquitin-protei (444 aa)
initn: 1511 init1: 1511 opt: 1524 Z-score: 1301.8 bits: 250.2 E(85289): 9e-66
Smith-Waterman score: 2876; 90.4% identity (90.4% similar) in 491 aa overlap (7-497:1-444)
10 20 30 40 50 60
pF1KB5 MVRSRQMCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVL
10 20 30 40 50
70 80 90 100 110 120
pF1KB5 FYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQE
60 70 80 90 100 110
130 140 150 160 170 180
pF1KB5 SSDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SSDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDE
120 130 140 150 160 170
190 200 210 220 230 240
pF1KB5 LSGERQRKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGD
::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LSGERQRKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGV------
180 190 200 210 220
250 260 270 280 290 300
pF1KB5 WLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEED
:::::::::::::::::::
NP_001 -----------------------------------------YQVTVYQAGESDTDSFEED
230 240
310 320 330 340 350 360
pF1KB5 PEISLADYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PEISLADYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAE
250 260 270 280 290 300
370 380 390 400 410 420
pF1KB5 EGFDVPDCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EGFDVPDCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEF
310 320 330 340 350 360
430 440 450 460 470 480
pF1KB5 EREETQDKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EREETQDKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKP
370 380 390 400 410 420
490
pF1KB5 CPVCRQPIQMIVLTYFP
:::::::::::::::::
NP_001 CPVCRQPIQMIVLTYFP
430 440
>>NP_001138812 (OMIM: 164785,614401) E3 ubiquitin-protei (295 aa)
initn: 1663 init1: 1347 opt: 1373 Z-score: 1176.5 bits: 226.4 E(85289): 8.6e-59
Smith-Waterman score: 1627; 90.3% identity (90.3% similar) in 269 aa overlap (229-497:53-295)
200 210 220 230 240 250
pF1KB5 FDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGDWLDQDSVSDQFSVEFEVE
::::::::::::::::::::::::::::::
NP_001 EQETLVRPKPLLLKLLKSVGAQKDTYTMKEDLDAGVSEHSGDWLDQDSVSDQFSVEFEVE
30 40 50 60 70 80
260 270 280 290 300 310
pF1KB5 SLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLADYWKCTSCNEMN
:::::::::::::::::::::: ::::::::::::
NP_001 SLDSEDYSLSEEGQELSDEDDE--------------------------DYWKCTSCNEMN
90 100 110
320 330 340 350 360 370
pF1KB5 PPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVPDCKKTIVNDSRE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVPDCKKTIVNDSRE
120 130 140 150 160 170
380 390 400 410 420 430
pF1KB5 SCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQDKEESVESSLPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQDKEESVESSLPL
180 190 200 210 220 230
440 450 460 470 480 490
pF1KB5 NAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVCRQPIQMIVLTYFP
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVCRQPIQMIVLTYFP
240 250 260 270 280 290
>--
initn: 329 init1: 329 opt: 329 Z-score: 293.1 bits: 63.0 E(85289): 1.4e-09
Smith-Waterman score: 329; 100.0% identity (100.0% similar) in 52 aa overlap (7-58:1-52)
10 20 30 40 50 60
pF1KB5 MVRSRQMCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVL
::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEDL
10 20 30 40 50
70 80 90 100 110 120
pF1KB5 FYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQE
NP_001 DAGVSEHSGDWLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEDYWKCTSCNE
60 70 80 90 100 110
>>NP_002384 (OMIM: 602704) protein Mdm4 isoform 1 [Homo (490 aa)
initn: 512 init1: 346 opt: 886 Z-score: 761.4 bits: 150.4 E(85289): 1.1e-35
Smith-Waterman score: 886; 34.0% identity (64.3% similar) in 482 aa overlap (30-495:23-488)
10 20 30 40 50 60
pF1KB5 MVRSRQMCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVL
: . :::: :::.:...::: . .:.:::.
NP_002 MTSFSTSAQCSTSDSACRISPGQINQVRPKLPLLKILHAAGAQGEMFTVKEVM
10 20 30 40 50
70 80 90 100 110 120
pF1KB5 FYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQE
:::::::.:.:::...::.:::..::::.:.: :::::. .: :. .:::..
NP_002 HYLGQYIMVKQLYDQQEQHMVYCGGDLLGELLGRQSFSVKDPSPLYDMLRKNLVTLATA-
60 70 80 90 100 110
130 140 150 160 170
pF1KB5 SSDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSR--PSTSSRRRAISETEENS
..:.. ... . : .: .: : .: . : .. . :. . .. ...:.
NP_002 TTDAAQTLALAQDHSMDIPSQDQLKQSAEESSTSRKRTTEDDIPTLPTSEHKCIHSREDE
120 130 140 150 160 170
180 190 200 210 220 230
pF1KB5 DELSGERQRKRHKSDSISLSFDE-SLA------LCVIREICCERSSSSESTGTPSNPDLD
: . . : . . : :.:.: ..: : .: ::.. :: .: :.
NP_002 DLIENLAQDETSRLD---LGFEEWDVAGLPWWFLGNLRSNYTPRSNG--STDLQTNQDVG
180 190 200 210 220
240 250 260 270 280
pF1KB5 -AGVSEHSGD-WLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQA
: ::. . : :. ..:::.:..: ..::. :.: . ::: ..::. .: .: .
NP_002 TAIVSDTTDDLWFLNESVSEQLGVGIKVEAADTE--QTSEEVGKVSDK--KVIEVGKNDD
230 240 250 260 270 280
290 300 310 320 330 340
pF1KB5 GESDTDSFEEDP--EISLADYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEI
: :. :. .: :.. : :.:: :...: : .: ::::::..: : .: .
NP_002 LE-DSKSLSDDTDVEVTSEDEWQCTECKKFNSPSKRYCFRCWALRKDWYS-DCSKLTHSL
290 300 310 320 330 340
350 360 370 380 390 400
pF1KB5 SEKAKLENSTQAEEGFDVPDCKKTI---VNDSRESCVEENDDKITQASQSQESEDYSQPS
: . . .:: :::::..:: : ... ......:. . .: : : .. :
NP_002 STSDITAIPEKENEGNDVPDCRRTISAPVVRPKDAYIKKENSKLFDPCNSVEFLDLAHSS
350 360 370 380 390 400
410 420 430 440 450 460
pF1KB5 TSSSIIYSSQEDVKEFEREETQDKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHL
:. : : :.. .. ...:. :..:. : ..:: .:. ::..: :.::.::::
NP_002 ESQETISSMGEQLDNLSEQRTD--TENMEDCQ--NLLKPCSLCEKRPRDGNIIHGRTGHL
410 420 430 440 450
470 480 490
pF1KB5 MACFTCAKKLKKRNKPCPVCRQPIQMIVLTYFP
..:: ::..::: . ::.:.. ::... ..
NP_002 VTCFHCARRLKKAGASCPICKKEIQLVIKVFIA
460 470 480 490
>>XP_016856800 (OMIM: 602704) PREDICTED: protein Mdm4 is (508 aa)
initn: 512 init1: 346 opt: 886 Z-score: 761.2 bits: 150.4 E(85289): 1.2e-35
Smith-Waterman score: 886; 34.0% identity (64.3% similar) in 482 aa overlap (30-495:41-506)
10 20 30 40 50
pF1KB5 MVRSRQMCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEV
: . :::: :::.:...::: . .:.:::
XP_016 DCSFFTTKMTSFSTSAQCSTSDSACRISPGQINQVRPKLPLLKILHAAGAQGEMFTVKEV
20 30 40 50 60 70
60 70 80 90 100 110
pF1KB5 LFYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQ
. :::::::.:.:::...::.:::..::::.:.: :::::. .: :. .:::..
XP_016 MHYLGQYIMVKQLYDQQEQHMVYCGGDLLGELLGRQSFSVKDPSPLYDMLRKNLVTLATA
80 90 100 110 120 130
120 130 140 150 160 170
pF1KB5 ESSDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSR--PSTSSRRRAISETEEN
..:.. ... . : .: .: : .: . : .. . :. . .. ...:.
XP_016 -TTDAAQTLALAQDHSMDIPSQDQLKQSAEESSTSRKRTTEDDIPTLPTSEHKCIHSRED
140 150 160 170 180
180 190 200 210 220 230
pF1KB5 SDELSGERQRKRHKSDSISLSFDE-SLA------LCVIREICCERSSSSESTGTPSNPDL
: . . : . . : :.:.: ..: : .: ::.. :: .: :.
XP_016 EDLIENLAQDETSRLD---LGFEEWDVAGLPWWFLGNLRSNYTPRSNG--STDLQTNQDV
190 200 210 220 230 240
240 250 260 270 280
pF1KB5 D-AGVSEHSGD-WLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQ
: ::. . : :. ..:::.:..: ..::. :.: . ::: ..::. .: .: .
XP_016 GTAIVSDTTDDLWFLNESVSEQLGVGIKVEAADTE--QTSEEVGKVSDK--KVIEVGKND
250 260 270 280 290 300
290 300 310 320 330 340
pF1KB5 AGESDTDSFEEDP--EISLADYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGE
: :. :. .: :.. : :.:: :...: : .: ::::::..: : .:
XP_016 DLE-DSKSLSDDTDVEVTSEDEWQCTECKKFNSPSKRYCFRCWALRKDWYS-DCSKLTHS
310 320 330 340 350
350 360 370 380 390 400
pF1KB5 ISEKAKLENSTQAEEGFDVPDCKKTI---VNDSRESCVEENDDKITQASQSQESEDYSQP
.: . . .:: :::::..:: : ... ......:. . .: : : ..
XP_016 LSTSDITAIPEKENEGNDVPDCRRTISAPVVRPKDAYIKKENSKLFDPCNSVEFLDLAHS
360 370 380 390 400 410
410 420 430 440 450 460
pF1KB5 STSSSIIYSSQEDVKEFEREETQDKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGH
: :. : : :.. .. ...:. :..:. : ..:: .:. ::..: :.::.:::
XP_016 SESQETISSMGEQLDNLSEQRTD--TENMEDCQ--NLLKPCSLCEKRPRDGNIIHGRTGH
420 430 440 450 460 470
470 480 490
pF1KB5 LMACFTCAKKLKKRNKPCPVCRQPIQMIVLTYFP
:..:: ::..::: . ::.:.. ::... ..
XP_016 LVTCFHCARRLKKAGASCPICKKEIQLVIKVFIA
480 490 500
497 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sat Nov 5 21:52:55 2016 done: Sat Nov 5 21:52:56 2016
Total Scan time: 10.850 Total Display time: 0.060
Function used was FASTA [36.3.4 Apr, 2011]