Result of FASTA (omim) for
pFN21AB6989
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB6989, 219 aa
1>>>pF1KB6989 219 - 219 aa - 219 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.1708+/-0.000373; mu= 13.7967+/- 0.023
mean_var=58.7891+/-11.992, 0's: 0 Z-trim(113.0): 28 B-trim: 649 in 1/51
Lambda= 0.167273
statistics sampled from 22093 (22120) to 22093 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.639), E-opt: 0.2 (0.259), width: 16
Scan time: 4.220
The best scores are: opt bits E(85289)
NP_002791 (OMIM: 177045) proteasome subunit beta t ( 219) 1434 354.3 8.8e-98
NP_002789 (OMIM: 600307) proteasome subunit beta t ( 239) 879 220.4 2e-57
NP_001257410 (OMIM: 600307) proteasome subunit bet ( 213) 722 182.5 4.6e-46
NP_004150 (OMIM: 177046,256040) proteasome subunit ( 272) 337 89.6 5.3e-18
NP_683720 (OMIM: 177046,256040) proteasome subunit ( 276) 337 89.6 5.3e-18
NP_002792 (OMIM: 176847) proteasome subunit beta t ( 273) 335 89.2 7.4e-18
NP_002790 (OMIM: 604030) proteasome subunit beta t ( 277) 316 84.6 1.8e-16
NP_002788 (OMIM: 600306) proteasome subunit beta t ( 263) 313 83.8 2.8e-16
NP_001093250 (OMIM: 611137) proteasome subunit bet ( 300) 295 79.5 6.4e-15
NP_001124197 (OMIM: 600306) proteasome subunit bet ( 160) 220 61.3 1e-09
NP_002786 (OMIM: 602176) proteasome subunit beta t ( 205) 220 61.4 1.3e-09
XP_005267928 (OMIM: 600306) PREDICTED: proteasome ( 169) 206 57.9 1.1e-08
NP_001138404 (OMIM: 600306) proteasome subunit bet ( 203) 205 57.7 1.6e-08
NP_002785 (OMIM: 602175) proteasome subunit beta t ( 201) 159 46.6 3.4e-05
NP_001186708 (OMIM: 602175) proteasome subunit bet ( 176) 146 43.5 0.00027
NP_002787 (OMIM: 602177) proteasome subunit beta t ( 264) 138 41.6 0.0015
NP_002781 (OMIM: 176844) proteasome subunit alpha ( 241) 134 40.6 0.0026
NP_001317605 (OMIM: 176846) proteasome subunit alp ( 261) 131 39.9 0.0047
NP_002780 (OMIM: 176846) proteasome subunit alpha ( 261) 131 39.9 0.0047
NP_001096137 (OMIM: 176846) proteasome subunit alp ( 261) 131 39.9 0.0047
NP_001317602 (OMIM: 176846) proteasome subunit alp ( 174) 125 38.4 0.009
>>NP_002791 (OMIM: 177045) proteasome subunit beta type- (219 aa)
initn: 1434 init1: 1434 opt: 1434 Z-score: 1876.4 bits: 354.3 E(85289): 8.8e-98
Smith-Waterman score: 1434; 100.0% identity (100.0% similar) in 219 aa overlap (1-219:1-219)
10 20 30 40 50 60
pF1KB6 MLRAGAPTGDLPRAGEVHTGTTIMAVEFDGGVVMGSDSRVSAGEAVVNRVFDKLSPLHER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 MLRAGAPTGDLPRAGEVHTGTTIMAVEFDGGVVMGSDSRVSAGEAVVNRVFDKLSPLHER
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB6 IYCALSGSAADAQAVADMAAYQLELHGIELEEPPLVLAAANVVRNISYKYREDLSAHLMV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 IYCALSGSAADAQAVADMAAYQLELHGIELEEPPLVLAAANVVRNISYKYREDLSAHLMV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB6 AGWDQREGGQVYGTLGGMLTRQPFAIGGSGSTFIYGYVDAAYKPGMSPEECRRFTTDAIA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 AGWDQREGGQVYGTLGGMLTRQPFAIGGSGSTFIYGYVDAAYKPGMSPEECRRFTTDAIA
130 140 150 160 170 180
190 200 210
pF1KB6 LAMSRDGSSGGVIYLVTITAAGVDHRVILGNELPKFYDE
:::::::::::::::::::::::::::::::::::::::
NP_002 LAMSRDGSSGGVIYLVTITAAGVDHRVILGNELPKFYDE
190 200 210
>>NP_002789 (OMIM: 600307) proteasome subunit beta type- (239 aa)
initn: 877 init1: 518 opt: 879 Z-score: 1152.0 bits: 220.4 E(85289): 2e-57
Smith-Waterman score: 879; 62.4% identity (89.1% similar) in 202 aa overlap (16-216:30-231)
10 20 30 40
pF1KB6 MLRAGAPTGDLPRAGEVHTGTTIMAVEFDGGVVMGSDSRVSAGEAV
:: ::::::::.::::::.:.:::...: .
NP_002 MAATLLAARGAGPAPAWGPEAFTPDWESREVSTGTTIMAVQFDGGVVLGADSRTTTGSYI
10 20 30 40 50 60
50 60 70 80 90 100
pF1KB6 VNRVFDKLSPLHERIYCALSGSAADAQAVADMAAYQLELHGIELEEPPLVLAAANVVRNI
.::: :::.:.:.::.: ::::::.::::: ..::: .:.:::.::::: .::.. ...
NP_002 ANRVTDKLTPIHDRIFCCRSGSAADTQAVADAVTYQLGFHSIELNEPPLVHTAASLFKEM
70 80 90 100 110 120
110 120 130 140 150 160
pF1KB6 SYKYREDLSAHLMVAGWDQREGGQVYGT-LGGMLTRQPFAIGGSGSTFIYGYVDAAYKPG
:.::::: : ...:::: .::::::.. .:::..:: ::::::::..:::::::.:. :
NP_002 CYRYREDLMAGIIIAGWDPQEGGQVYSVPMGGMMVRQSFAIGGSGSSYIYGYVDATYREG
130 140 150 160 170 180
170 180 190 200 210
pF1KB6 MSPEECRRFTTDAIALAMSRDGSSGGVIYLVTITAAGVDHRVILGNELPKFYDE
:. ::: .::..:.:::: ::::::::: :..:. .::...:.::...:::
NP_002 MTKEECLQFTANALALAMERDGSSGGVIRLAAIAESGVERQVLLGDQIPKFAVATLPPA
190 200 210 220 230
>>NP_001257410 (OMIM: 600307) proteasome subunit beta ty (213 aa)
initn: 717 init1: 518 opt: 722 Z-score: 948.0 bits: 182.5 E(85289): 4.6e-46
Smith-Waterman score: 722; 62.8% identity (88.4% similar) in 164 aa overlap (16-178:30-193)
10 20 30 40
pF1KB6 MLRAGAPTGDLPRAGEVHTGTTIMAVEFDGGVVMGSDSRVSAGEAV
:: ::::::::.::::::.:.:::...: .
NP_001 MAATLLAARGAGPAPAWGPEAFTPDWESREVSTGTTIMAVQFDGGVVLGADSRTTTGSYI
10 20 30 40 50 60
50 60 70 80 90 100
pF1KB6 VNRVFDKLSPLHERIYCALSGSAADAQAVADMAAYQLELHGIELEEPPLVLAAANVVRNI
.::: :::.:.:.::.: ::::::.::::: ..::: .:.:::.::::: .::.. ...
NP_001 ANRVTDKLTPIHDRIFCCRSGSAADTQAVADAVTYQLGFHSIELNEPPLVHTAASLFKEM
70 80 90 100 110 120
110 120 130 140 150 160
pF1KB6 SYKYREDLSAHLMVAGWDQREGGQVYGT-LGGMLTRQPFAIGGSGSTFIYGYVDAAYKPG
:.::::: : ...:::: .::::::.. .:::..:: ::::::::..:::::::.:. :
NP_001 CYRYREDLMAGIIIAGWDPQEGGQVYSVPMGGMMVRQSFAIGGSGSSYIYGYVDATYREG
130 140 150 160 170 180
170 180 190 200 210
pF1KB6 MSPEECRRFTTDAIALAMSRDGSSGGVIYLVTITAAGVDHRVILGNELPKFYDE
:. ::: .::..:
NP_001 MTKEECLQFTANAFFFYPQLSLWPWSGMAPVEE
190 200 210
>>NP_004150 (OMIM: 177046,256040) proteasome subunit bet (272 aa)
initn: 330 init1: 197 opt: 337 Z-score: 444.2 bits: 89.6 E(85289): 5.3e-18
Smith-Waterman score: 337; 33.8% identity (58.1% similar) in 198 aa overlap (9-202:55-251)
10 20 30
pF1KB6 MLRAGAPTGDLPRAGEVHT--GTTIMAVEFDGGVVMGS
:: : ... ::: .: .:. ::. .
NP_004 AAPLDDTTLPTPVSSGCPGLEPTEFFQSLGGDGERNVQIEMAHGTTTLAFKFQHGVIAAV
30 40 50 60 70 80
40 50 60 70 80 90
pF1KB6 DSRVSAGEAVVNRVFDKLSPLHERIYCALSGSAADAQAVADMAAYQLELHGIELEEPPLV
:::.::: . .:. .. . ..:: ::: : . : . .:. .. : :
NP_004 DSRASAGSYISALRVNKVIEINPYLLGTMSGCAADCQYWERLLAKECRLYYLRNGERISV
90 100 110 120 130 140
100 110 120 130 140 150
pF1KB6 LAAANVVRNISYKYR-EDLSAHLMVAGWDQREGGQVY-GTLGGMLTRQPFAIGGSGSTFI
::.... :. .:: :: :. :::.. : : : :. . :. : ::.:.
NP_004 SAASKLLSNMMCQYRGMGLSMGSMICGWDKKGPGLYYVDEHGTRLSGNMFSTG-SGNTYA
150 160 170 180 190 200
160 170 180 190 200 210
pF1KB6 YGYVDAAYKPGMSPEECRRFTTDAIALAMSRDGSSGGVIYLVTITAAGVDHRVILGNELP
:: .:..:.:..:::: . ::: : ::. ::::. . . :
NP_004 YGVMDSGYRPNLSPEEAYDLGRRAIAYATHRDSYSGGVVNMYHMKEDGWVKVESTDVSDL
210 220 230 240 250 260
pF1KB6 KFYDE
NP_004 LHQYREANQ
270
>>NP_683720 (OMIM: 177046,256040) proteasome subunit bet (276 aa)
initn: 354 init1: 197 opt: 337 Z-score: 444.1 bits: 89.6 E(85289): 5.3e-18
Smith-Waterman score: 337; 33.8% identity (58.1% similar) in 198 aa overlap (9-202:59-255)
10 20 30
pF1KB6 MLRAGAPTGDLPRAGEVHT--GTTIMAVEFDGGVVMGS
:: : ... ::: .: .:. ::. .
NP_683 DPGHYSFSMRSPELALPRGMQPTEFFQSLGGDGERNVQIEMAHGTTTLAFKFQHGVIAAV
30 40 50 60 70 80
40 50 60 70 80 90
pF1KB6 DSRVSAGEAVVNRVFDKLSPLHERIYCALSGSAADAQAVADMAAYQLELHGIELEEPPLV
:::.::: . .:. .. . ..:: ::: : . : . .:. .. : :
NP_683 DSRASAGSYISALRVNKVIEINPYLLGTMSGCAADCQYWERLLAKECRLYYLRNGERISV
90 100 110 120 130 140
100 110 120 130 140 150
pF1KB6 LAAANVVRNISYKYR-EDLSAHLMVAGWDQREGGQVY-GTLGGMLTRQPFAIGGSGSTFI
::.... :. .:: :: :. :::.. : : : :. . :. : ::.:.
NP_683 SAASKLLSNMMCQYRGMGLSMGSMICGWDKKGPGLYYVDEHGTRLSGNMFSTG-SGNTYA
150 160 170 180 190 200
160 170 180 190 200 210
pF1KB6 YGYVDAAYKPGMSPEECRRFTTDAIALAMSRDGSSGGVIYLVTITAAGVDHRVILGNELP
:: .:..:.:..:::: . ::: : ::. ::::. . . :
NP_683 YGVMDSGYRPNLSPEEAYDLGRRAIAYATHRDSYSGGVVNMYHMKEDGWVKVESTDVSDL
210 220 230 240 250 260
pF1KB6 KFYDE
NP_683 LHQYREANQ
270
>>NP_002792 (OMIM: 176847) proteasome subunit beta type- (273 aa)
initn: 306 init1: 306 opt: 335 Z-score: 441.6 bits: 89.2 E(85289): 7.4e-18
Smith-Waterman score: 335; 30.5% identity (64.5% similar) in 197 aa overlap (7-202:28-221)
10 20 30
pF1KB6 MLRAGAPTGDLPRAGEVHTGTTIMAVEFDGGVVMGSDSR
: .:.: . ::::: .. :. ::..:.:.:
NP_002 MLKPALEPRGGFSFENCQRNASLERVLPGLKVPHARK--TGTTIAGLVFQDGVILGADTR
10 20 30 40 50
40 50 60 70 80 90
pF1KB6 VSAGEAVVNRVFDKLSPLHERIYCALSGSAADAQAVADMAAYQLELHGIELEEPPLVLAA
.. .:... .:. . .::: .: ::::. .. :.: ..:::.. . : : ..
NP_002 ATNDSVVADKSCEKIHFIAPKIYCCGAGVAADAEMTTRMVASKMELHALSTGREPRVATV
60 70 80 90 100 110
100 110 120 130 140 150
pF1KB6 ANVVRNISYKYREDLSAHLMVAGWDQREGGQVYGTLG-GMLTRQPFAIGGSGSTFIYGYV
. ..:. ..:. ..: :.:.: : : :.::. : .: ::. :::. . .
NP_002 TRILRQTLFRYQGHVGASLIVGGVDLT-GPQLYGVHPHGSYSRLPFTALGSGQDAALAVL
120 130 140 150 160 170
160 170 180 190 200 210
pF1KB6 DAAYKPGMSPEECRRFTTDAIALAMSRDGSSGGVIYLVTITAAGVDHRVILGNELPKFYD
. ..:.:. : . . ..:.. .. : .::: . .:: .:
NP_002 EDRFQPNMTLEAAQGLLVEAVTAGILGDLGSGGNVDACVITKTGAKLLRTLSSPTEPVKR
180 190 200 210 220 230
pF1KB6 E
NP_002 SGRYHFVPGTTAVLTQTVKPLTLELVEETVQAMEVE
240 250 260 270
>>NP_002790 (OMIM: 604030) proteasome subunit beta type- (277 aa)
initn: 326 init1: 302 opt: 316 Z-score: 416.7 bits: 84.6 E(85289): 1.8e-16
Smith-Waterman score: 316; 29.2% identity (64.6% similar) in 195 aa overlap (11-204:36-227)
10 20 30 40
pF1KB6 MLRAGAPTGDLPRAGEVHTGTTIMAVEFDGGVVMGSDSRV
::.. . ::::: .: . :.:.:.:.:.
NP_002 VYAPPVGGFSFDNCRRNAVLEADFAKRGYKLPKVRK--TGTTIAGVVYKDGIVLGADTRA
10 20 30 40 50 60
50 60 70 80 90 100
pF1KB6 SAGEAVVNRVFDKLSPLHERIYCALSGSAADAQAVADMAAYQLELHGIELEEPPLVLAAA
. : .:... .:. . ::: .:.:::.. .... . .::::.. . : :..:
NP_002 TEGMVVADKNCSKIHFISPNIYCCGAGTAADTDMTTQLISSNLELHSLSTGRLPRVVTAN
70 80 90 100 110 120
110 120 130 140 150
pF1KB6 NVVRNISYKYREDLSAHLMVAGWDQREGGQVYGTLG-GMLTRQPFAIGGSGSTFIYGYVD
..... ..:. ..: :...: : : ..:. : . :.. :::: .. .
NP_002 RMLKQMLFRYQGYIGAALVLGGVDVT-GPHLYSIYPHGSTDKLPYVTMGSGSLAAMAVFE
130 140 150 160 170 180
160 170 180 190 200 210
pF1KB6 AAYKPGMSPEECRRFTTDAIALAMSRDGSSGGVIYLVTITAAGVDHRVILGNELPKFYDE
..: : :: . ....::: .. : .::. : : .:. .:
NP_002 DKFRPDMEEEEAKNLVSEAIAAGIFNDLGSGSNIDLCVISKNKLDFLRPYTVPNKKGTRL
190 200 210 220 230 240
NP_002 GRYRCEKGTTAVLTEKITPLEIEVLEETVQTMDTS
250 260 270
>>NP_002788 (OMIM: 600306) proteasome subunit beta type- (263 aa)
initn: 326 init1: 155 opt: 313 Z-score: 413.2 bits: 83.8 E(85289): 2.8e-16
Smith-Waterman score: 313; 29.8% identity (59.5% similar) in 205 aa overlap (2-202:39-242)
10 20
pF1KB6 MLRAGAPTGDLPRAG--EVHTGTTIMAVEFD
: .:: .:. :. ::: .: .:
NP_002 RPLPVNQRGFFGLGGRADLLDLGPGSLSDGLSLAAPGWGVPEEPGIEMLHGTTTLAFKFR
10 20 30 40 50 60
30 40 50 60 70 80
pF1KB6 GGVVMGSDSRVSAGEAVVNRVFDKLSPLHERIYCALSGSAADAQAVADMAAYQLELHGIE
::....:::..:: ..... :. .. . ...:.::: . . : : ... ..
NP_002 HGVIVAADSRATAGAYIASQTVKKVIEINPYLLGTMAGGAADCSFWERLLARQCRIYELR
70 80 90 100 110 120
90 100 110 120 130 140
pF1KB6 LEEPPLVLAAANVVRNISYKYR-EDLSAHLMVAGWDQREGGQVY-GTLGGMLTRQPFAIG
.: : ::.... :. :.:. :: :. :::.: : : . :. .. :..:
NP_002 NKERISVAAASKLLANMVYQYKGMGLSMGTMICGWDKRGPGLYYVDSEGNRISGATFSVG
130 140 150 160 170 180
150 160 170 180 190 200
pF1KB6 GSGSTFIYGYVDAAYKPGMSPEECRRFTTDAIALAMSRDGSSGGVIYLVTITAAGVDHRV
:::.. :: .: .:. . :. .. :: : ::. :::.. : . :
NP_002 -SGSVYAYGVMDRGYSYDLEVEQAYDLARRAIYQATYRDAYSGGAVNLYHVREDGWIRVS
190 200 210 220 230 240
210
pF1KB6 ILGNELPKFYDE
NP_002 SDNVADLHEKYSGSTP
250 260
>>NP_001093250 (OMIM: 611137) proteasome subunit beta ty (300 aa)
initn: 312 init1: 154 opt: 295 Z-score: 388.8 bits: 79.5 E(85289): 6.4e-15
Smith-Waterman score: 297; 30.7% identity (57.2% similar) in 215 aa overlap (3-205:23-235)
10 20 30
pF1KB6 MLRAGA---PTGDLPRAG-EVHT-----GTTIMAVEFDGG
:::. : : :.. ..: ::: .: .: :
NP_001 MALQDVCKWQSPDTQGPSPHLPRAGGWAVPRGCDPQTFLQIHGPRLAHGTTTLAFRFRHG
10 20 30 40 50 60
40 50 60 70 80 90
pF1KB6 VVMGSDSRVSAGEAVVNRVFDKLSPLHERIYCALSGSAADAQAVADMAAYQLELHGIELE
:. ..:.: : : :. . :. :.:... . ::..:: . . .:.:. ..
NP_001 VIAAADTRSSCGSYVACPASCKVIPVHQHLLGTTSGTSADCATWYRVLQRELRLRELREG
70 80 90 100 110 120
100 110 120 130 140
pF1KB6 EPPLVLAAANVVRNISYKYRE-DLSAHLMVAGWDQREGGQVYGTL--GGMLTRQPFAIGG
. : : .::... . .:: :: . . ::: : : ... . : : . :..:
NP_001 QLPSVASAAKLLSAMMSQYRGLDLCVATALCGWD-RSGPELFYVYSDGTRLQGDIFSVG-
130 140 150 160 170
150 160 170 180 190 200
pF1KB6 SGSTFIYGYVDAAYKPGMSPEECRRFTTDAIALAMSRDGSSGGVIYLVTITAAGVDHRVI
::: . :: .: .:. :: .: .. :.: : ::. ::: . : . .: .:
NP_001 SGSPYAYGVLDRGYRYDMSTQEAYALARCAVAHATHRDAYSGGSVDLFHVRESGWEHVSR
180 190 200 210 220 230
210
pF1KB6 LGNELPKFYDE
NP_001 SDACVLYVELQKLLEPEPEEDASHAHPEPATAHRAAEDRELSVGPGEVTPGDSRMPAGTE
240 250 260 270 280 290
>>NP_001124197 (OMIM: 600306) proteasome subunit beta ty (160 aa)
initn: 181 init1: 149 opt: 220 Z-score: 295.2 bits: 61.3 E(85289): 1e-09
Smith-Waterman score: 220; 30.7% identity (58.6% similar) in 140 aa overlap (65-202:1-139)
40 50 60 70 80 90
pF1KB6 GSDSRVSAGEAVVNRVFDKLSPLHERIYCALSGSAADAQAVADMAAYQLELHGIELEEPP
..:.::: . . : : ... .. .:
NP_001 MAGGAADCSFWERLLARQCRIYELRNKERI
10 20 30
100 110 120 130 140 150
pF1KB6 LVLAAANVVRNISYKYR-EDLSAHLMVAGWDQREGGQVY-GTLGGMLTRQPFAIGGSGST
: ::.... :. :.:. :: :. :::.: : : . :. .. :..: :::.
NP_001 SVAAASKLLANMVYQYKGMGLSMGTMICGWDKRGPGLYYVDSEGNRISGATFSVG-SGSV
40 50 60 70 80
160 170 180 190 200 210
pF1KB6 FIYGYVDAAYKPGMSPEECRRFTTDAIALAMSRDGSSGGVIYLVTITAAGVDHRVILGNE
. :: .: .:. . :. .. :: : ::. :::.. : . :
NP_001 YAYGVMDRGYSYDLEVEQAYDLARRAIYQATYRDAYSGGAVNLYHVREDGWIRVSSDNVA
90 100 110 120 130 140
pF1KB6 LPKFYDE
NP_001 DLHEKYSGSTP
150 160
219 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Fri Nov 4 10:20:38 2016 done: Fri Nov 4 10:20:39 2016
Total Scan time: 4.220 Total Display time: 0.010
Function used was FASTA [36.3.4 Apr, 2011]