Result of FASTA (omim) for
pFN21AB6949
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB6949, 211 aa
1>>>pF1KB6949 211 - 211 aa - 211 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 4.8527+/-0.000361; mu= 15.8543+/- 0.022
mean_var=58.5850+/-12.005, 0's: 0 Z-trim(113.7): 57 B-trim: 45 in 1/48
Lambda= 0.167564
statistics sampled from 23105 (23178) to 23105 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.633), E-opt: 0.2 (0.272), width: 16
Scan time: 5.870
The best scores are: opt bits E(85289)
NP_001171951 (OMIM: 609131) claudin-7 isoform 1 pr ( 211) 1414 349.9 1.8e-96
NP_001298 (OMIM: 609131) claudin-7 isoform 1 precu ( 211) 1414 349.9 1.8e-96
NP_066924 (OMIM: 603718,607626) claudin-1 [Homo sa ( 211) 925 231.7 7e-61
NP_001171952 (OMIM: 609131) claudin-7 isoform 2 pr ( 145) 864 216.8 1.4e-56
NP_001116867 (OMIM: 248190,610036) claudin-19 isof ( 211) 841 211.4 9.1e-55
NP_683763 (OMIM: 248190,610036) claudin-19 isoform ( 224) 830 208.7 6e-54
NP_001296 (OMIM: 602909) claudin-4 [Homo sapiens] ( 209) 714 180.6 1.6e-45
NP_001297 (OMIM: 602910) claudin-3 [Homo sapiens] ( 220) 710 179.7 3.2e-45
NP_066192 (OMIM: 615799) claudin-9 [Homo sapiens] ( 217) 700 177.3 1.7e-44
NP_067018 (OMIM: 615798) claudin-6 precursor [Homo ( 220) 685 173.6 2.1e-43
NP_003268 (OMIM: 602101) claudin-5 [Homo sapiens] ( 303) 663 168.4 1.1e-41
NP_001124333 (OMIM: 602101) claudin-5 [Homo sapien ( 303) 663 168.4 1.1e-41
XP_016884419 (OMIM: 602101) PREDICTED: claudin-5 i ( 303) 663 168.4 1.1e-41
XP_016884418 (OMIM: 602101) PREDICTED: claudin-5 i ( 303) 663 168.4 1.1e-41
NP_036262 (OMIM: 605608,614035) claudin-14 [Homo s ( 239) 625 159.2 5.2e-39
NP_652763 (OMIM: 605608,614035) claudin-14 [Homo s ( 239) 625 159.2 5.2e-39
NP_001139551 (OMIM: 605608,614035) claudin-14 [Hom ( 239) 625 159.2 5.2e-39
NP_001139549 (OMIM: 605608,614035) claudin-14 [Hom ( 239) 625 159.2 5.2e-39
NP_001139550 (OMIM: 605608,614035) claudin-14 [Hom ( 239) 625 159.2 5.2e-39
NP_955360 (OMIM: 611231) claudin-8 [Homo sapiens] ( 225) 624 158.9 5.9e-39
NP_001172046 (OMIM: 248190,610036) claudin-19 isof ( 218) 611 155.8 5.1e-38
NP_036263 (OMIM: 617005) claudin-17 [Homo sapiens] ( 224) 584 149.2 4.8e-36
NP_001164566 (OMIM: 300520) claudin-2 [Homo sapien ( 230) 561 143.7 2.3e-34
NP_065117 (OMIM: 300520) claudin-2 [Homo sapiens] ( 230) 561 143.7 2.3e-34
NP_001164563 (OMIM: 300520) claudin-2 [Homo sapien ( 230) 561 143.7 2.3e-34
NP_001172009 (OMIM: 615778) claudin-15 [Homo sapie ( 228) 536 137.6 1.5e-32
NP_055158 (OMIM: 615778) claudin-15 [Homo sapiens] ( 228) 536 137.6 1.5e-32
NP_001002026 (OMIM: 609210) claudin-18 isoform 2 [ ( 261) 388 101.9 9.9e-22
NP_057453 (OMIM: 609210) claudin-18 isoform 1 prec ( 261) 381 100.2 3.2e-21
NP_005593 (OMIM: 601326) claudin-11 isoform 1 [Hom ( 207) 357 94.3 1.5e-19
NP_006571 (OMIM: 248250,603959) claudin-16 [Homo s ( 305) 293 79.0 9.2e-15
NP_919260 (OMIM: 609203) claudin-23 [Homo sapiens] ( 292) 250 68.6 1.2e-11
NP_001171985 (OMIM: 601326) claudin-11 isoform 2 p ( 123) 186 52.9 2.7e-07
NP_001172001 (OMIM: 611232) claudin-12 [Homo sapie ( 244) 146 43.4 0.00038
NP_001172002 (OMIM: 611232) claudin-12 [Homo sapie ( 244) 146 43.4 0.00038
NP_036261 (OMIM: 611232) claudin-12 [Homo sapiens] ( 244) 146 43.4 0.00038
NP_665810 (OMIM: 606405) voltage-dependent calcium ( 275) 132 40.0 0.0044
>>NP_001171951 (OMIM: 609131) claudin-7 isoform 1 precur (211 aa)
initn: 1414 init1: 1414 opt: 1414 Z-score: 1852.9 bits: 349.9 E(85289): 1.8e-96
Smith-Waterman score: 1414; 99.5% identity (100.0% similar) in 211 aa overlap (1-211:1-211)
10 20 30 40 50 60
pF1KB6 MANSGLQLLGFSMALLGWVGLVACTAIPQWQMSSYAGDNIITAQAMYKGLWMDCVTQSTG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MANSGLQLLGFSMALLGWVGLVACTAIPQWQMSSYAGDNIITAQAMYKGLWMDCVTQSTG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB6 MMSCKMYDSVLALSAALQATRALMVVSLVLGFLAMFVATMGMKCTRCGGDDKVKKARIAM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MMSCKMYDSVLALSAALQATRALMVVSLVLGFLAMFVATMGMKCTRCGGDDKVKKARIAM
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB6 GGGIIFIVAGLAALVACSWYGHQIVTDFYNPLIPTNIKYEFGPAIFIGWAGSALVILGGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GGGIIFIVAGLAALVACSWYGHQIVTDFYNPLIPTNIKYEFGPAIFIGWAGSALVILGGA
130 140 150 160 170 180
190 200 210
pF1KB6 LLSCSCPGNESKAGYRAPRSYPKSNSSKEYV
::::::::::::::::.::::::::::::::
NP_001 LLSCSCPGNESKAGYRVPRSYPKSNSSKEYV
190 200 210
>>NP_001298 (OMIM: 609131) claudin-7 isoform 1 precursor (211 aa)
initn: 1414 init1: 1414 opt: 1414 Z-score: 1852.9 bits: 349.9 E(85289): 1.8e-96
Smith-Waterman score: 1414; 99.5% identity (100.0% similar) in 211 aa overlap (1-211:1-211)
10 20 30 40 50 60
pF1KB6 MANSGLQLLGFSMALLGWVGLVACTAIPQWQMSSYAGDNIITAQAMYKGLWMDCVTQSTG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MANSGLQLLGFSMALLGWVGLVACTAIPQWQMSSYAGDNIITAQAMYKGLWMDCVTQSTG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB6 MMSCKMYDSVLALSAALQATRALMVVSLVLGFLAMFVATMGMKCTRCGGDDKVKKARIAM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MMSCKMYDSVLALSAALQATRALMVVSLVLGFLAMFVATMGMKCTRCGGDDKVKKARIAM
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB6 GGGIIFIVAGLAALVACSWYGHQIVTDFYNPLIPTNIKYEFGPAIFIGWAGSALVILGGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GGGIIFIVAGLAALVACSWYGHQIVTDFYNPLIPTNIKYEFGPAIFIGWAGSALVILGGA
130 140 150 160 170 180
190 200 210
pF1KB6 LLSCSCPGNESKAGYRAPRSYPKSNSSKEYV
::::::::::::::::.::::::::::::::
NP_001 LLSCSCPGNESKAGYRVPRSYPKSNSSKEYV
190 200 210
>>NP_066924 (OMIM: 603718,607626) claudin-1 [Homo sapien (211 aa)
initn: 911 init1: 911 opt: 925 Z-score: 1214.0 bits: 231.7 E(85289): 7e-61
Smith-Waterman score: 925; 60.6% identity (86.4% similar) in 213 aa overlap (1-211:1-211)
10 20 30 40 50 60
pF1KB6 MANSGLQLLGFSMALLGWVGLVACTAIPQWQMSSYAGDNIITAQAMYKGLWMDCVTQSTG
:::.::::::: .:.:::.: .. ::.:::.. :::::::.::::::.::::.::.::::
NP_066 MANAGLQLLGFILAFLGWIGAIVSTALPQWRIYSYAGDNIVTAQAMYEGLWMSCVSQSTG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB6 MMSCKMYDSVLALSAALQATRALMVVSLVLGFLAMFVATMGMKCTRCGGDDKVKKARIAM
...::..::.: ::..::::::::::...:: .:.::::.:::: .: ::.:.: :.:.
NP_066 QIQCKVFDSLLNLSSTLQATRALMVVGILLGVIAIFVATVGMKCMKCLEDDEVQKMRMAV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB6 GGGIIFIVAGLAALVACSWYGHQIVTDFYNPLIPTNIKYEFGPAIFIGWAGSALVILGGA
:: ::..:::: ::: .:::..:: .::.:. :.: .:::: :.: :::...: .::::
NP_066 IGGAIFLLAGLAILVATAWYGNRIVQEFYDPMTPVNARYEFGQALFTGWAAASLCLLGGA
130 140 150 160 170 180
190 200 210
pF1KB6 LLSCSCPGNESKAGYRAPRSYPKS--NSSKEYV
:: :::: .. ..: .:: ::: .:.:.::
NP_066 LLCCSCP--RKTTSYPTPRPYPKPAPSSGKDYV
190 200 210
>>NP_001171952 (OMIM: 609131) claudin-7 isoform 2 precur (145 aa)
initn: 878 init1: 864 opt: 864 Z-score: 1136.7 bits: 216.8 E(85289): 1.4e-56
Smith-Waterman score: 864; 98.5% identity (100.0% similar) in 132 aa overlap (1-132:1-132)
10 20 30 40 50 60
pF1KB6 MANSGLQLLGFSMALLGWVGLVACTAIPQWQMSSYAGDNIITAQAMYKGLWMDCVTQSTG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MANSGLQLLGFSMALLGWVGLVACTAIPQWQMSSYAGDNIITAQAMYKGLWMDCVTQSTG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB6 MMSCKMYDSVLALSAALQATRALMVVSLVLGFLAMFVATMGMKCTRCGGDDKVKKARIAM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MMSCKMYDSVLALSAALQATRALMVVSLVLGFLAMFVATMGMKCTRCGGDDKVKKARIAM
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB6 GGGIIFIVAGLAALVACSWYGHQIVTDFYNPLIPTNIKYEFGPAIFIGWAGSALVILGGA
::::::::::..
NP_001 GGGIIFIVAGMSLALPSLLAGQGLP
130 140
>>NP_001116867 (OMIM: 248190,610036) claudin-19 isoform (211 aa)
initn: 841 init1: 841 opt: 841 Z-score: 1104.3 bits: 211.4 E(85289): 9.1e-55
Smith-Waterman score: 841; 53.6% identity (83.4% similar) in 211 aa overlap (1-211:1-211)
10 20 30 40 50 60
pF1KB6 MANSGLQLLGFSMALLGWVGLVACTAIPQWQMSSYAGDNIITAQAMYKGLWMDCVTQSTG
::::::::::. .:: ::::..: ::.:::..:::::: :::: ..:.::::.:..::::
NP_001 MANSGLQLLGYFLALGGWVGIIASTALPQWKQSSYAGDAIITAVGLYEGLWMSCASQSTG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB6 MMSCKMYDSVLALSAALQATRALMVVSLVLGFLAMFVATMGMKCTRCGGDDKVKKARIAM
...::.:::.:::.. .:..::::::...:::.:: ....:::::: : .. . :.:.:.
NP_001 QVQCKLYDSLLALDGHIQSARALMVVAVLLGFVAMVLSVVGMKCTRVGDSNPIAKGRVAI
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB6 GGGIIFIVAGLAALVACSWYGHQIVTDFYNPLIPTNIKYEFGPAIFIGWAGSALVILGGA
.:: .::.::: .:.: :::. .. .:.:: :.: .::::::.:.:::...:..:::.
NP_001 AGGALFILAGLCTLTAVSWYATLVTQEFFNPSTPVNARYEFGPALFVGWASAGLAVLGGS
130 140 150 160 170 180
190 200 210
pF1KB6 LLSCSCPGNESKAGYRAPRSYPKSNSSKEYV
.: :.:: : . : : ...:::
NP_001 FLCCTCPEPERPNSSPQPYRPGPSAAAREYV
190 200 210
>>NP_683763 (OMIM: 248190,610036) claudin-19 isoform a [ (224 aa)
initn: 819 init1: 819 opt: 830 Z-score: 1089.5 bits: 208.7 E(85289): 6e-54
Smith-Waterman score: 830; 53.1% identity (82.9% similar) in 211 aa overlap (1-211:1-211)
10 20 30 40 50 60
pF1KB6 MANSGLQLLGFSMALLGWVGLVACTAIPQWQMSSYAGDNIITAQAMYKGLWMDCVTQSTG
::::::::::. .:: ::::..: ::.:::..:::::: :::: ..:.::::.:..::::
NP_683 MANSGLQLLGYFLALGGWVGIIASTALPQWKQSSYAGDAIITAVGLYEGLWMSCASQSTG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB6 MMSCKMYDSVLALSAALQATRALMVVSLVLGFLAMFVATMGMKCTRCGGDDKVKKARIAM
...::.:::.:::.. .:..::::::...:::.:: ....:::::: : .. . :.:.:.
NP_683 QVQCKLYDSLLALDGHIQSARALMVVAVLLGFVAMVLSVVGMKCTRVGDSNPIAKGRVAI
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB6 GGGIIFIVAGLAALVACSWYGHQIVTDFYNPLIPTNIKYEFGPAIFIGWAGSALVILGGA
.:: .::.::: .:.: :::. .. .:.:: :.: .::::::.:.:::...:..:::.
NP_683 AGGALFILAGLCTLTAVSWYATLVTQEFFNPSTPVNARYEFGPALFVGWASAGLAVLGGS
130 140 150 160 170 180
190 200 210
pF1KB6 LLSCSCPGNESKAGYRAPRSYPKSNSSKEYV
.: :.:: : . : : ...: :
NP_683 FLCCTCPEPERPNSSPQPYRPGPSAAAREPVVKLPASAKGPLGV
190 200 210 220
>>NP_001296 (OMIM: 602909) claudin-4 [Homo sapiens] (209 aa)
initn: 744 init1: 438 opt: 714 Z-score: 938.4 bits: 180.6 E(85289): 1.6e-45
Smith-Waterman score: 714; 44.1% identity (82.0% similar) in 211 aa overlap (1-211:1-209)
10 20 30 40 50 60
pF1KB6 MANSGLQLLGFSMALLGWVGLVACTAIPQWQMSSYAGDNIITAQAMYKGLWMDCVTQSTG
::. :::..:...:.:::.... : :.:.:..... :.::.:.:....::::.::.::::
NP_001 MASMGLQVMGIALAVLGWLAVMLCCALPMWRVTAFIGSNIVTSQTIWEGLWMNCVVQSTG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB6 MMSCKMYDSVLALSAALQATRALMVVSLVLGFLAMFVATMGMKCTRCGGDDKVKKARIAM
.:.::.:::.::: :::.:::...:.... :.......: ::: : .:. ::. .
NP_001 QMQCKVYDSLLALPQDLQAARALVIISIIVAALGVLLSVVGGKCTNCL-EDESAKAKTMI
70 80 90 100 110
130 140 150 160 170 180
pF1KB6 GGGIIFIVAGLAALVACSWYGHQIVTDFYNPLIPTNIKYEFGPAIFIGWAGSALVILGGA
.:..:..::: ..: :: .:.:. ::::::. .. : :.: ....:::.:.:..:::.
NP_001 VAGVVFLLAGLMVIVPVSWTAHNIIQDFYNPLVASGQKREMGASLYVGWAASGLLLLGGG
120 130 140 150 160 170
190 200 210
pF1KB6 LLSCSCPGNESKAGYRAPRSYPKSNSSKEYV
:: :.:: .: : : : .: ....::
NP_001 LLCCNCPPRTDKP-YSAKYSAARSAAASNYV
180 190 200
>>NP_001297 (OMIM: 602910) claudin-3 [Homo sapiens] (220 aa)
initn: 726 init1: 430 opt: 710 Z-score: 932.9 bits: 179.7 E(85289): 3.2e-45
Smith-Waterman score: 710; 48.8% identity (80.1% similar) in 201 aa overlap (5-200:4-203)
10 20 30 40 50 60
pF1KB6 MANSGLQLLGFSMALLGWVGLVACTAIPQWQMSSYAGDNIITAQAMYKGLWMDCVTQSTG
::.. : ..:.:::.: ..: :.:.:..:.. :.::::.: ...::::.::.::::
NP_001 MSMGLEITGTALAVLGWLGTIVCCALPMWRVSAFIGSNIITSQNIWEGLWMNCVVQSTG
10 20 30 40 50
70 80 90 100 110 120
pF1KB6 MMSCKMYDSVLALSAALQATRALMVVSLVLGFLAMFVATMGMKCTRCGGDDKVKKARIAM
.:.::.:::.::: :::.:::.::...:. ....:: .: .:: : :: .: :.:..
NP_001 QMQCKVYDSLLALPQDLQAARALIVVAILLAAFGLLVALVGAQCTNCVQDDTAK-AKITI
60 70 80 90 100 110
130 140 150 160 170 180
pF1KB6 GGGIIFIVAGLAALVACSWYGHQIVTDFYNPLIPTNIKYEFGPAIFIGWAGSALVILGGA
.:..:..:.: .:: :: .. :. :::::..: : :.: ....:::..:: .::::
NP_001 VAGVLFLLAALLTLVPVSWSANTIIRDFYNPVVPEAQKREMGAGLYVGWAAAALQLLGGA
120 130 140 150 160 170
190 200 210
pF1KB6 LLSCSCPGNE-----SKAGYRAPRSYPKSNSSKEYV
:: :::: : .:. : ::::
NP_001 LLCCSCPPREKKYTATKVVYSAPRSTGPGASLGTGYDRKDYV
180 190 200 210 220
>>NP_066192 (OMIM: 615799) claudin-9 [Homo sapiens] (217 aa)
initn: 443 init1: 443 opt: 700 Z-score: 919.9 bits: 177.3 E(85289): 1.7e-44
Smith-Waterman score: 700; 45.2% identity (79.0% similar) in 219 aa overlap (1-211:1-217)
10 20 30 40 50
pF1KB6 MANSGLQLLGFSMALLGWVG-LVACTAIPQWQMSSYAGDNIITAQAMYKGLWMDCVTQST
::..::.:::...:.:::.: ::.: :.: :..... :..:..::....::::.::.:::
NP_066 MASTGLELLGMTLAVLGWLGTLVSC-ALPLWKVTAFIGNSIVVAQVVWEGLWMSCVVQST
10 20 30 40 50
60 70 80 90 100 110
pF1KB6 GMMSCKMYDSVLALSAALQATRALMVVSLVLGFLAMFVATMGMKCTRCGGDDKVKKARIA
:.:.::.:::.::: :::.::: :..:.:..:...:: : .:: : .:. ::::.
NP_066 GQMQCKVYDSLLALPQDLQAARALCVIALLLALLGLLVAITGAQCTTCV-EDEGAKARIV
60 70 80 90 100 110
120 130 140 150 160 170
pF1KB6 MGGGIIFIVAGLAALVACSWYGHQIVTDFYNPLIPTNIKYEFGPAIFIGWAGSALVILGG
. .:.:...::. .:. : .: :. ::::::. .: :.: ....:::..::..:::
NP_066 LTAGVILLLAGILVLIPVCWTAHAIIQDFYNPLVAEALKRELGASLYLGWAAAALLMLGG
120 130 140 150 160 170
180 190 200 210
pF1KB6 ALLSCSCPGNE------SKAGYRAP-RSYPKSNSSKEYV
.:: :.:: . . :: : :: .. ....::
NP_066 GLLCCTCPPPQVERPRGPRLGYSIPSRSGASGLDKRDYV
180 190 200 210
>>NP_067018 (OMIM: 615798) claudin-6 precursor [Homo sap (220 aa)
initn: 676 init1: 407 opt: 685 Z-score: 900.2 bits: 173.6 E(85289): 2.1e-43
Smith-Waterman score: 685; 44.9% identity (78.7% similar) in 216 aa overlap (1-210:1-214)
10 20 30 40 50
pF1KB6 MANSGLQLLGFSMALLGWV-GLVACTAIPQWQMSSYAGDNIITAQAMYKGLWMDCVTQST
::..:.:.:: ..::::: :::.: :.:.:..... :..:..::....::::.::.:::
NP_067 MASAGMQILGVVLTLLGWVNGLVSC-ALPMWKVTAFIGNSIVVAQVVWEGLWMSCVVQST
10 20 30 40 50
60 70 80 90 100 110
pF1KB6 GMMSCKMYDSVLALSAALQATRALMVVSLVLGFLAMFVATMGMKCTRCGGDDKVKKARIA
:.:.::.:::.::: :::.::: :..:........: : ::: : ..: .:::..
NP_067 GQMQCKVYDSLLALPQDLQAARALCVIALLVALFGLLVYLAGAKCTTCV-EEKDSKARLV
60 70 80 90 100 110
120 130 140 150 160 170
pF1KB6 MGGGIIFIVAGLAALVACSWYGHQIVTDFYNPLIPTNIKYEFGPAIFIGWAGSALVILGG
. .::.:...:. .:. : .: :. ::::::. : :.: ....:::.:.:..:::
NP_067 LTSGIVFVISGVLTLIPVCWTAHAIIRDFYNPLVAEAQKRELGASLYLGWAASGLLLLGG
120 130 140 150 160 170
180 190 200 210
pF1KB6 ALLSCSCP--GNESKAGY--RAPRSYPK-SNSSKEYV
.:: :.:: :... . : : : : : . .::
NP_067 GLLCCTCPSGGSQGPSHYMARYSTSAPAISRGPSEYPTKNYV
180 190 200 210 220
211 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Fri Nov 4 11:30:51 2016 done: Fri Nov 4 11:30:52 2016
Total Scan time: 5.870 Total Display time: 0.000
Function used was FASTA [36.3.4 Apr, 2011]