Result of FASTA (omim) for
pFN21AB6911
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB6911, 205 aa
1>>>pF1KB6911 205 - 205 aa - 205 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 4.7434+/-0.000401; mu= 16.4221+/- 0.025
mean_var=59.1563+/-12.127, 0's: 0 Z-trim(110.3): 31 B-trim: 705 in 1/51
Lambda= 0.166753
statistics sampled from 18585 (18613) to 18585 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.596), E-opt: 0.2 (0.218), width: 16
Scan time: 5.320
The best scores are: opt bits E(85289)
NP_002786 (OMIM: 602176) proteasome subunit beta t ( 205) 1367 337.2 1.1e-92
NP_002784 (OMIM: 602017) proteasome subunit beta t ( 241) 287 77.5 2e-14
NP_002791 (OMIM: 177045) proteasome subunit beta t ( 219) 220 61.3 1.3e-09
NP_002789 (OMIM: 600307) proteasome subunit beta t ( 239) 213 59.7 4.6e-09
NP_004150 (OMIM: 177046,256040) proteasome subunit ( 272) 188 53.7 3.3e-07
NP_683720 (OMIM: 177046,256040) proteasome subunit ( 276) 188 53.7 3.3e-07
NP_002788 (OMIM: 600306) proteasome subunit beta t ( 263) 184 52.7 6.3e-07
NP_001257410 (OMIM: 600307) proteasome subunit bet ( 213) 177 51.0 1.7e-06
NP_002785 (OMIM: 602175) proteasome subunit beta t ( 201) 154 45.4 7.5e-05
NP_001093250 (OMIM: 611137) proteasome subunit bet ( 300) 155 45.8 8.8e-05
NP_002790 (OMIM: 604030) proteasome subunit beta t ( 277) 154 45.5 9.7e-05
NP_001138404 (OMIM: 600306) proteasome subunit bet ( 203) 131 39.9 0.0035
NP_001124197 (OMIM: 600306) proteasome subunit bet ( 160) 128 39.1 0.0048
NP_001186708 (OMIM: 602175) proteasome subunit bet ( 176) 127 38.9 0.0061
XP_005267928 (OMIM: 600306) PREDICTED: proteasome ( 169) 125 38.4 0.0083
>>NP_002786 (OMIM: 602176) proteasome subunit beta type- (205 aa)
initn: 1367 init1: 1367 opt: 1367 Z-score: 1785.0 bits: 337.2 E(85289): 1.1e-92
Smith-Waterman score: 1367; 100.0% identity (100.0% similar) in 205 aa overlap (1-205:1-205)
10 20 30 40 50 60
pF1KB6 MSIMSYNGGAVMAMKGKNCVAIAADRRFGIQAQMVTTDFQKIFPMGDRLYIGLAGLATDV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 MSIMSYNGGAVMAMKGKNCVAIAADRRFGIQAQMVTTDFQKIFPMGDRLYIGLAGLATDV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB6 QTVAQRLKFRLNLYELKEGRQIKPYTLMSMVANLLYEKRFGPYYTEPVIAGLDPKTFKPF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 QTVAQRLKFRLNLYELKEGRQIKPYTLMSMVANLLYEKRFGPYYTEPVIAGLDPKTFKPF
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB6 ICSLDLIGCPMVTDDFVVSGTCAEQMYGMCESLWEPNMDPDHLFETISQAMLNAVDRDAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 ICSLDLIGCPMVTDDFVVSGTCAEQMYGMCESLWEPNMDPDHLFETISQAMLNAVDRDAV
130 140 150 160 170 180
190 200
pF1KB6 SGMGVIVHIIEKDKITTRTLKARMD
:::::::::::::::::::::::::
NP_002 SGMGVIVHIIEKDKITTRTLKARMD
190 200
>>NP_002784 (OMIM: 602017) proteasome subunit beta type- (241 aa)
initn: 224 init1: 224 opt: 287 Z-score: 379.8 bits: 77.5 E(85289): 2e-14
Smith-Waterman score: 287; 25.8% identity (64.1% similar) in 209 aa overlap (6-205:35-241)
10 20 30
pF1KB6 MSIMSYNGGAVMAMKGKNCVAIAADRRFGIQAQMV
.:::...:. :.. . .:.: :.. ..
NP_002 TAMYSAPGRDLGMEPHRAAGPLQLRFSPYVFNGGTILAIAGEDFAIVASDTRLSEGFSIH
10 20 30 40 50 60
40 50 60 70 80 90
pF1KB6 TTDFQKIFPMGDRLYIGLAGLATDVQTVAQRLKFRLNLYELKEGRQIKPYTLMSMVANLL
: : : . . :. :: .:. : :... .. ::..:. .... . .. .:....:
NP_002 TRDSPKCYKLTDKTVIGCSGFHGDCLTLTKIIEARLKMYKHSNNKAMTTGAIAAMLSTIL
70 80 90 100 110 120
100 110 120 130 140 150
pF1KB6 YEKRFGPYYTEPVIAGLDPKTFKPFICSLDLIGCPMVTDDFVVSGTCAEQMYGMCES-LW
: .:: :::. .:.::: . : . :.: .: . :.: ..:. . .. . .. .
NP_002 YSRRFFPYYVYNIIGGLDEEG-KGAVYSFDPVGS-YQRDSFKAGGSASAMLQPLLDNQVG
130 140 150 160 170 180
160 170 180 190 200
pF1KB6 EPNM-DPDHLFETISQAM-------LNAVDRDAVSGMGVIVHIIEKDKITTRTLKARMD
:: . .:. ....:: ..:..::. .: .. . :. :. : .:.. : :
NP_002 FKNMQNVEHVPLSLDRAMRLVKDVFISAAERDVYTGDALRICIVTKEGIREETVSLRKD
190 200 210 220 230 240
>>NP_002791 (OMIM: 177045) proteasome subunit beta type- (219 aa)
initn: 97 init1: 77 opt: 220 Z-score: 293.3 bits: 61.3 E(85289): 1.3e-09
Smith-Waterman score: 220; 27.6% identity (63.2% similar) in 185 aa overlap (6-186:18-193)
10 20 30 40
pF1KB6 MSIMSYNGGAVMAMKGKNCVAIAADRRFGIQAQMVTTDFQKIFPMGDR
..: ..::.. . :....: : . .:. :.:. :. .:
NP_002 MLRAGAPTGDLPRAGEVHTGTTIMAVEFDGGVVMGSDSRVSAGEAVVNRVFDKLSPLHER
10 20 30 40 50 60
50 60 70 80 90 100
pF1KB6 LYIGLAGLATDVQTVAQRLKFRLNLY--ELKEGRQIKPYTLMS--MVANLLYEKRFGPYY
.: .:.: :.:.:.::. ..:.:. ::.: : .: . .: :. :. :
NP_002 IYCALSGSAADAQAVADMAAYQLELHGIELEE----PPLVLAAANVVRNISYKYRED-LS
70 80 90 100 110
110 120 130 140 150 160
pF1KB6 TEPVIAGLDPKTFKPFICSLDLIGCPMVTDDFVVSGTCAEQMYGMCESLWEPNMDPDHLF
.. ..:: : . .: : .. . :...:. . .::. .. ..:.:.:..
NP_002 AHLMVAGWDQREGGQVYGTL---GGMLTRQPFAIGGSGSTFIYGYVDAAYKPGMSPEECR
120 130 140 150 160 170
170 180 190 200
pF1KB6 ETISQAMLNAVDRDAVSGMGVIVHIIEKDKITTRTLKARMD
. ..:. :..::. :: :::
NP_002 RFTTDAIALAMSRDGSSG-GVIYLVTITAAGVDHRVILGNELPKFYDE
180 190 200 210
>>NP_002789 (OMIM: 600307) proteasome subunit beta type- (239 aa)
initn: 202 init1: 99 opt: 213 Z-score: 283.7 bits: 59.7 E(85289): 4.6e-09
Smith-Waterman score: 213; 25.1% identity (63.1% similar) in 179 aa overlap (8-186:34-208)
10 20 30
pF1KB6 MSIMSYNGGAVMAMKGKNCVAIAADRRFGIQAQMVTT
: ..::.. . :...:: : . ...
NP_002 TLLAARGAGPAPAWGPEAFTPDWESREVSTGTTIMAVQFDGGVVLGADSRTTTGSYIANR
10 20 30 40 50 60
40 50 60 70 80 90
pF1KB6 DFQKIFPMGDRLYIGLAGLATDVQTVAQRLKFRLNLYELKEGRQIKPYTLMSMVANLLYE
.:. :. ::.. .: :.:.:.::. . ..:... .. .. .: :. .. :.
NP_002 VTDKLTPIHDRIFCCRSGSAADTQAVADAVTYQLGFHSIELNEPPLVHTAASLFKEMCYR
70 80 90 100 110 120
100 110 120 130 140 150
pF1KB6 KRFGPYYTEPVIAGLDPKTFKPFICSLDLIGCPMVTDDFVVSGTCAEQMYGMCESLWEPN
: .. .::: ::. . :. . : :: ..:...:. . .::. .. .. .
NP_002 YRED-LMAGIIIAGWDPQEGGQ-VYSVPMGGM-MVRQSFAIGGSGSSYIYGYVDATYREG
130 140 150 160 170 180
160 170 180 190 200
pF1KB6 MDPDHLFETISQAMLNAVDRDAVSGMGVIVHIIEKDKITTRTLKARMD
: .. .. ..:. :..::. :: :::
NP_002 MTKEECLQFTANALALAMERDGSSG-GVIRLAAIAESGVERQVLLGDQIPKFAVATLPPA
190 200 210 220 230
>>NP_004150 (OMIM: 177046,256040) proteasome subunit bet (272 aa)
initn: 103 init1: 86 opt: 188 Z-score: 250.4 bits: 53.7 E(85289): 3.3e-07
Smith-Waterman score: 188; 23.0% identity (56.7% similar) in 187 aa overlap (7-193:67-250)
10 20 30
pF1KB6 MSIMSYNGGAVMAMKGKNCVAIAADRRFGIQAQMVT
.: ...:.: .. : :.: : . . . .
NP_004 VSSGCPGLEPTEFFQSLGGDGERNVQIEMAHGTTTLAFKFQHGVIAAVDSRASAGSYISA
40 50 60 70 80 90
40 50 60 70 80 90
pF1KB6 TDFQKIFPMGDRLYIGLAGLATDVQTVAQRLKFRLNLYELKEGRQIKPYTLMSMVANLLY
.:.. .. : ..: :.: : . : . :: :..:..:. . ....:..
NP_004 LRVNKVIEINPYLLGTMSGCAADCQYWERLLAKECRLYYLRNGERISVSAASKLLSNMMC
100 110 120 130 140 150
100 110 120 130 140 150
pF1KB6 EKRFGPYYTEPVIAGLDPKTFKPFICSLDLIGCPMVTDDFVVSGTCAEQMYGMCESLWEP
. : .: : : : : . .: : . . .. .:. ::. .: ..:
NP_004 QYRGMGLSMGSMICGWDKKG--PGLYYVDEHGTRL-SGNMFSTGSGNTYAYGVMDSGYRP
160 170 180 190 200 210
160 170 180 190 200
pF1KB6 NMDPDHLFETISQAMLNAVDRDAVSGMGVIVHIIEKDKITTRTLKARMD
:..:.. .. .:. :. ::. :: : .. ...:
NP_004 NLSPEEAYDLGRRAIAYATHRDSYSGGVVNMYHMKEDGWVKVESTDVSDLLHQYREANQ
220 230 240 250 260 270
>>NP_683720 (OMIM: 177046,256040) proteasome subunit bet (276 aa)
initn: 86 init1: 86 opt: 188 Z-score: 250.3 bits: 53.7 E(85289): 3.3e-07
Smith-Waterman score: 188; 23.0% identity (56.7% similar) in 187 aa overlap (7-193:71-254)
10 20 30
pF1KB6 MSIMSYNGGAVMAMKGKNCVAIAADRRFGIQAQMVT
.: ...:.: .. : :.: : . . . .
NP_683 ELALPRGMQPTEFFQSLGGDGERNVQIEMAHGTTTLAFKFQHGVIAAVDSRASAGSYISA
50 60 70 80 90 100
40 50 60 70 80 90
pF1KB6 TDFQKIFPMGDRLYIGLAGLATDVQTVAQRLKFRLNLYELKEGRQIKPYTLMSMVANLLY
.:.. .. : ..: :.: : . : . :: :..:..:. . ....:..
NP_683 LRVNKVIEINPYLLGTMSGCAADCQYWERLLAKECRLYYLRNGERISVSAASKLLSNMMC
110 120 130 140 150 160
100 110 120 130 140 150
pF1KB6 EKRFGPYYTEPVIAGLDPKTFKPFICSLDLIGCPMVTDDFVVSGTCAEQMYGMCESLWEP
. : .: : : : : . .: : . . .. .:. ::. .: ..:
NP_683 QYRGMGLSMGSMICGWDKKG--PGLYYVDEHGTRL-SGNMFSTGSGNTYAYGVMDSGYRP
170 180 190 200 210
160 170 180 190 200
pF1KB6 NMDPDHLFETISQAMLNAVDRDAVSGMGVIVHIIEKDKITTRTLKARMD
:..:.. .. .:. :. ::. :: : .. ...:
NP_683 NLSPEEAYDLGRRAIAYATHRDSYSGGVVNMYHMKEDGWVKVESTDVSDLLHQYREANQ
220 230 240 250 260 270
>>NP_002788 (OMIM: 600306) proteasome subunit beta type- (263 aa)
initn: 151 init1: 95 opt: 184 Z-score: 245.4 bits: 52.7 E(85289): 6.3e-07
Smith-Waterman score: 184; 23.0% identity (56.1% similar) in 187 aa overlap (7-193:58-241)
10 20 30
pF1KB6 MSIMSYNGGAVMAMKGKNCVAIAADRRFGIQAQMVT
.: ...:.: .. : .::: : : ...
NP_002 LDLGPGSLSDGLSLAAPGWGVPEEPGIEMLHGTTTLAFKFRHGVIVAADSRATAGAYIAS
30 40 50 60 70 80
40 50 60 70 80 90
pF1KB6 TDFQKIFPMGDRLYIGLAGLATDVQTVAQRLKFRLNLYELKEGRQIKPYTLMSMVANLLY
.:.. .. : .:: :.: . . : . .:::.. ..:. . ...::..:
NP_002 QTVKKVIEINPYLLGTMAGGAADCSFWERLLARQCRIYELRNKERISVAAASKLLANMVY
90 100 110 120 130 140
100 110 120 130 140 150
pF1KB6 EKRFGPYYTEPVIAGLDPKTFKPFICSLDLIGCPMVTDDFVVSGTCAEQMYGMCESLWEP
. . .: : : . : . .: : . : : :. . ::. . .
NP_002 QYKGMGLSMGTMICGWDKRG--PGLYYVDSEGNRISGATFSV-GSGSVYAYGVMDRGYSY
150 160 170 180 190 200
160 170 180 190 200
pF1KB6 NMDPDHLFETISQAMLNAVDRDAVSGMGVIVHIIEKDKITTRTLKARMD
... .. .. .:. .:. ::: :: .: .. ...:
NP_002 DLEVEQAYDLARRAIYQATYRDAYSGGAVNLYHVREDGWIRVSSDNVADLHEKYSGSTP
210 220 230 240 250 260
>>NP_001257410 (OMIM: 600307) proteasome subunit beta ty (213 aa)
initn: 172 init1: 99 opt: 177 Z-score: 237.6 bits: 51.0 E(85289): 1.7e-06
Smith-Waterman score: 177; 22.4% identity (62.4% similar) in 165 aa overlap (8-172:34-195)
10 20 30
pF1KB6 MSIMSYNGGAVMAMKGKNCVAIAADRRFGIQAQMVTT
: ..::.. . :...:: : . ...
NP_001 TLLAARGAGPAPAWGPEAFTPDWESREVSTGTTIMAVQFDGGVVLGADSRTTTGSYIANR
10 20 30 40 50 60
40 50 60 70 80 90
pF1KB6 DFQKIFPMGDRLYIGLAGLATDVQTVAQRLKFRLNLYELKEGRQIKPYTLMSMVANLLYE
.:. :. ::.. .: :.:.:.::. . ..:... .. .. .: :. .. :.
NP_001 VTDKLTPIHDRIFCCRSGSAADTQAVADAVTYQLGFHSIELNEPPLVHTAASLFKEMCYR
70 80 90 100 110 120
100 110 120 130 140 150
pF1KB6 KRFGPYYTEPVIAGLDPKTFKPFICSLDLIGCPMVTDDFVVSGTCAEQMYGMCESLWEPN
: .. .::: ::. . :. . : :: ..:...:. . .::. .. .. .
NP_001 YRED-LMAGIIIAGWDPQEGGQ-VYSVPM-GGMMVRQSFAIGGSGSSYIYGYVDATYREG
130 140 150 160 170 180
160 170 180 190 200
pF1KB6 MDPDHLFETISQAMLNAVDRDAVSGMGVIVHIIEKDKITTRTLKARMD
: .. .. ..:..
NP_001 MTKEECLQFTANAFFFYPQLSLWPWSGMAPVEE
190 200 210
>>NP_002785 (OMIM: 602175) proteasome subunit beta type- (201 aa)
initn: 39 init1: 39 opt: 154 Z-score: 208.0 bits: 45.4 E(85289): 7.5e-05
Smith-Waterman score: 154; 19.3% identity (57.2% similar) in 187 aa overlap (11-195:4-188)
10 20 30 40 50 60
pF1KB6 MSIMSYNGGAVMAMKGKNCVAIAADRRFGIQAQMVTTDFQKIFPMGDRLYIGLAGLATDV
.....: . : .:.:: . . .. : .:.: :.... . .: : :.
NP_002 MEYLIGIQGPDYVLVASDRVAASNIVQMKDDHDKMFKMSEKILLLCVGEAGDT
10 20 30 40 50
70 80 90 100 110
pF1KB6 QTVAQRLKFRLNLYELKEGRQIKPYTLMSMVANLLYE--KRFGPYYTEPVIAGLDPKTFK
:. .. ..::....: ...: . ... : . . ::... ..:: : .
NP_002 VQFAEYIQKNVQLYKMRNGYELSPTAAANFTRRNLADCLRSRTPYHVNLLLAGYDEHE-G
60 70 80 90 100 110
120 130 140 150 160 170
pF1KB6 PFICSLDLIGCPMVTDDFVVSGTCAEQMYGMCESLWEPNMDPDHLFETISQAMLNAVDRD
: . .: .. .. :.. : : .. . . :... .. : . . . . :
NP_002 PALYYMDYLAA-LAKAPFAAHGYGAFLTLSILDRYYTPTISRERAVELLRKCLEELQKRF
120 130 140 150 160 170
180 190 200
pF1KB6 AVSGMGVIVHIIEKDKITTRTLKARMD
.. :.::.:. :
NP_002 ILNLPTFSVRIIDKNGIHDLDNISFPKQGS
180 190 200
>>NP_001093250 (OMIM: 611137) proteasome subunit beta ty (300 aa)
initn: 82 init1: 57 opt: 155 Z-score: 206.9 bits: 45.8 E(85289): 8.8e-05
Smith-Waterman score: 155; 23.1% identity (53.8% similar) in 186 aa overlap (7-191:48-230)
10 20 30
pF1KB6 MSIMSYNGGAVMAMKGKNCVAIAADRRFGIQAQMVT
.: ...:.. .. : ::: : . . ..
NP_001 SPHLPRAGGWAVPRGCDPQTFLQIHGPRLAHGTTTLAFRFRHGVIAAADTRSSCGSYVAC
20 30 40 50 60 70
40 50 60 70 80 90
pF1KB6 TDFQKIFPMGDRLYIGLAGLATDVQTVAQRLKFRLNLYELKEGRQIKPYTLMSMVANLLY
:..:. ..: .: ..: : . :. .: : ::.::. . . .... ..
NP_001 PASCKVIPVHQHLLGTTSGTSADCATWYRVLQRELRLRELREGQLPSVASAAKLLSAMMS
80 90 100 110 120 130
100 110 120 130 140 150
pF1KB6 EKRFGPYYTEPVIAGLDPKTFKPFICSLDLIGCPMVTDDFVVSGTCAEQMYGMCESLWEP
. : . .. : : . . : : : . : : : :. . ::. . ..
NP_001 QYRGLDLCVATALCGWDRSGPELFYVYSD--GTRLQGDIFSV-GSGSPYAYGVLDRGYRY
140 150 160 170 180 190
160 170 180 190 200
pF1KB6 NMDPDHLFETISQAMLNAVDRDAVSGMGV-IVHIIEKDKITTRTLKARMD
.:. .. . :. .:. ::: :: .: . :. :
NP_001 DMSTQEAYALARCAVAHATHRDAYSGGSVDLFHVRESGWEHVSRSDACVLYVELQKLLEP
200 210 220 230 240 250
NP_001 EPEEDASHAHPEPATAHRAAEDRELSVGPGEVTPGDSRMPAGTETV
260 270 280 290 300
205 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Fri Nov 4 13:00:35 2016 done: Fri Nov 4 13:00:36 2016
Total Scan time: 5.320 Total Display time: 0.000
Function used was FASTA [36.3.4 Apr, 2011]