Result of FASTA (omim) for
pFN21AE1007
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE1007, 196 aa
1>>>pF1KE1007 196 - 196 aa - 196 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 6.0498+/-0.000397; mu= 11.4523+/- 0.025
mean_var=102.6219+/-19.758, 0's: 0 Z-trim(113.2): 28 B-trim: 165 in 1/53
Lambda= 0.126606
statistics sampled from 22431 (22458) to 22431 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.626), E-opt: 0.2 (0.263), width: 16
Scan time: 5.530
The best scores are: opt bits E(85289)
NP_002759 (OMIM: 164010,614961) charged multivesic ( 196) 1196 228.5 5.3e-60
NP_065145 (OMIM: 606486) charged multivesicular bo ( 199) 682 134.6 9.8e-32
NP_055268 (OMIM: 610893) charged multivesicular bo ( 222) 258 57.2 2.2e-08
NP_940818 (OMIM: 610893) charged multivesicular bo ( 222) 258 57.2 2.2e-08
XP_005258804 (OMIM: 610893) PREDICTED: charged mul ( 265) 243 54.5 1.7e-07
XP_005258803 (OMIM: 610893) PREDICTED: charged mul ( 265) 243 54.5 1.7e-07
NP_054762 (OMIM: 600795,609512,614696) charged mul ( 213) 179 42.8 0.00047
XP_011531878 (OMIM: 600795,609512,614696) PREDICTE ( 229) 179 42.8 0.0005
NP_001231573 (OMIM: 600795,609512,614696) charged ( 172) 163 39.8 0.003
>>NP_002759 (OMIM: 164010,614961) charged multivesicular (196 aa)
initn: 1196 init1: 1196 opt: 1196 Z-score: 1198.2 bits: 228.5 E(85289): 5.3e-60
Smith-Waterman score: 1196; 100.0% identity (100.0% similar) in 196 aa overlap (1-196:1-196)
10 20 30 40 50 60
pF1KE1 MDDTLFQLKFTAKQLEKLAKKAEKDSKAEQAKVKKALLQKNVECARVYAENAIRKKNEGV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 MDDTLFQLKFTAKQLEKLAKKAEKDSKAEQAKVKKALLQKNVECARVYAENAIRKKNEGV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 NWLRMASRVDAVASKVQTAVTMKGVTKNMAQVTKALDKALSTMDLQKVSSVMDRFEQQVQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 NWLRMASRVDAVASKVQTAVTMKGVTKNMAQVTKALDKALSTMDLQKVSSVMDRFEQQVQ
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 NLDVHTSVMEDSMSSATTLTTPQEQVDSLIMQIAEENGLEVLDQLSQLPEGASAVGESSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 NLDVHTSVMEDSMSSATTLTTPQEQVDSLIMQIAEENGLEVLDQLSQLPEGASAVGESSV
130 140 150 160 170 180
190
pF1KE1 RSQEDQLSRRLAALRN
::::::::::::::::
NP_002 RSQEDQLSRRLAALRN
190
>>NP_065145 (OMIM: 606486) charged multivesicular body p (199 aa)
initn: 723 init1: 609 opt: 682 Z-score: 690.7 bits: 134.6 E(85289): 9.8e-32
Smith-Waterman score: 682; 55.8% identity (85.3% similar) in 197 aa overlap (1-196:4-197)
10 20 30 40 50
pF1KE1 MDDTLFQLKFTAKQLEKLAKKAEKDSKAEQAKVKKALLQKNVECARVYAENAIRKKN
:. ::.:::.::.: . ::: .:. :::.::.:::. . :.: ::..::::::.::
NP_065 MSNMEKHLFNLKFAAKELSRSAKKCDKEEKAEKAKIKKAIQKGNMEVARIHAENAIRQKN
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE1 EGVNWLRMASRVDAVASKVQTAVTMKGVTKNMAQVTKALDKALSTMDLQKVSSVMDRFEQ
..::.:::..::::::..::::::: :::.:: :.:..: .:.::.:.:.:..::.::.
NP_065 QAVNFLRMSARVDAVAARVQTAVTMGKVTKSMAGVVKSMDATLKTMNLEKISALMDKFEH
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE1 QVQNLDVHTSVMEDSMSSATTLTTPQEQVDSLIMQIAEENGLEVLDQLSQLPEGAS-AVG
: ..:::.:. :::.:::.:::::::.::: :....:.: :: : .::.: . .::
NP_065 QFETLDVQTQQMEDTMSSTTTLTTPQNQVDMLLQEMADEAGL---DLNMELPQGQTGSVG
130 140 150 160 170
180 190
pF1KE1 ESSVRSQEDQLSRRLAALRN
: . ...:.::.::: ::.
NP_065 TSVASAEQDELSQRLARLRDQV
180 190
>>NP_055268 (OMIM: 610893) charged multivesicular body p (222 aa)
initn: 215 init1: 199 opt: 258 Z-score: 271.5 bits: 57.2 E(85289): 2.2e-08
Smith-Waterman score: 260; 27.1% identity (62.8% similar) in 199 aa overlap (8-195:22-220)
10 20 30 40
pF1KE1 MDDTLFQLKFTAKQLEKLAKKAEKDSKAEQAKVKKALLQKNVECAR
:. . ..:.. .: : . : : .:: : ... .:
NP_055 MDLLFGRRKTPEELLRQNQRALNRAMRELDRERQKLETQEKKIIADIKKMAKQGQMDAVR
10 20 30 40 50 60
50 60 70 80 90 100
pF1KE1 VYAENAIRKKNEGVNWLRMASRVDAVASKVQTAVTMKGVTKNMAQVTKALDKALSTMDLQ
..:.. .: . ... : . ..::. :.:: . ..... : ::::. . :
NP_055 IMAKDLVRTRRYVRKFVLMRANIQAVSLKIQTLKSNNSMAQAMKGVTKAMGTMNRQLKLP
70 80 90 100 110 120
110 120 130 140 150 160
pF1KE1 KVSSVMDRFEQQVQNLDVHTSVMEDSMSSATTLTTPQEQVDSLIMQIAEENGLEVLDQLS
.....: .::.:.. .:.. .:.:....: .:. :... :. .: :: . :.::
NP_055 QIQKIMMEFERQAEIMDMKEEMMNDAIDDAMGDEEDEEESDAVVSQVLDELGLSLTDELS
130 140 150 160 170 180
170 180 190
pF1KE1 QLPE-GAS---AVG----ESSVRSQED---QLSRRLAALRN
.:: :.: :.: :... . : .: .:: ::
NP_055 NLPSTGGSLSVAAGGKKAEAAASALADADADLEERLKNLRRD
190 200 210 220
>>NP_940818 (OMIM: 610893) charged multivesicular body p (222 aa)
initn: 215 init1: 199 opt: 258 Z-score: 271.5 bits: 57.2 E(85289): 2.2e-08
Smith-Waterman score: 260; 27.1% identity (62.8% similar) in 199 aa overlap (8-195:22-220)
10 20 30 40
pF1KE1 MDDTLFQLKFTAKQLEKLAKKAEKDSKAEQAKVKKALLQKNVECAR
:. . ..:.. .: : . : : .:: : ... .:
NP_940 MDLLFGRRKTPEELLRQNQRALNRAMRELDRERQKLETQEKKIIADIKKMAKQGQMDAVR
10 20 30 40 50 60
50 60 70 80 90 100
pF1KE1 VYAENAIRKKNEGVNWLRMASRVDAVASKVQTAVTMKGVTKNMAQVTKALDKALSTMDLQ
..:.. .: . ... : . ..::. :.:: . ..... : ::::. . :
NP_940 IMAKDLVRTRRYVRKFVLMRANIQAVSLKIQTLKSNNSMAQAMKGVTKAMGTMNRQLKLP
70 80 90 100 110 120
110 120 130 140 150 160
pF1KE1 KVSSVMDRFEQQVQNLDVHTSVMEDSMSSATTLTTPQEQVDSLIMQIAEENGLEVLDQLS
.....: .::.:.. .:.. .:.:....: .:. :... :. .: :: . :.::
NP_940 QIQKIMMEFERQAEIMDMKEEMMNDAIDDAMGDEEDEEESDAVVSQVLDELGLSLTDELS
130 140 150 160 170 180
170 180 190
pF1KE1 QLPE-GAS---AVG----ESSVRSQED---QLSRRLAALRN
.:: :.: :.: :... . : .: .:: ::
NP_940 NLPSTGGSLSVAAGGKKAEAAASALADADADLEERLKNLRRD
190 200 210 220
>>XP_005258804 (OMIM: 610893) PREDICTED: charged multive (265 aa)
initn: 200 init1: 184 opt: 243 Z-score: 255.7 bits: 54.5 E(85289): 1.7e-07
Smith-Waterman score: 243; 25.8% identity (64.8% similar) in 159 aa overlap (8-166:22-180)
10 20 30 40
pF1KE1 MDDTLFQLKFTAKQLEKLAKKAEKDSKAEQAKVKKALLQKNVECAR
:. . ..:.. .: : . : : .:: : ... .:
XP_005 MDLLFGRRKTPEELLRQNQRALNRAMRELDRERQKLETQEKKIIADIKKMAKQGQMDAVR
10 20 30 40 50 60
50 60 70 80 90 100
pF1KE1 VYAENAIRKKNEGVNWLRMASRVDAVASKVQTAVTMKGVTKNMAQVTKALDKALSTMDLQ
..:.. .: . ... : . ..::. :.:: . ..... : ::::. . :
XP_005 IMAKDLVRTRRYVRKFVLMRANIQAVSLKIQTLKSNNSMAQAMKGVTKAMGTMNRQLKLP
70 80 90 100 110 120
110 120 130 140 150 160
pF1KE1 KVSSVMDRFEQQVQNLDVHTSVMEDSMSSATTLTTPQEQVDSLIMQIAEENGLEVLDQLS
.....: .::.:.. .:.. .:.:....: .:. :... :. .: :: . :.::
XP_005 QIQKIMMEFERQAEIMDMKEEMMNDAIDDAMGDEEDEEESDAVVSQVLDELGLSLTDELS
130 140 150 160 170 180
170 180 190
pF1KE1 QLPEGASAVGESSVRSQEDQLSRRLAALRN
XP_005 SECSKSWTPFPTQGPATAPSPPFPCITPLRCLTPPAQTPTFSADLPSTGGSLSVAAGGKK
190 200 210 220 230 240
>>XP_005258803 (OMIM: 610893) PREDICTED: charged multive (265 aa)
initn: 200 init1: 184 opt: 243 Z-score: 255.7 bits: 54.5 E(85289): 1.7e-07
Smith-Waterman score: 243; 25.8% identity (64.8% similar) in 159 aa overlap (8-166:22-180)
10 20 30 40
pF1KE1 MDDTLFQLKFTAKQLEKLAKKAEKDSKAEQAKVKKALLQKNVECAR
:. . ..:.. .: : . : : .:: : ... .:
XP_005 MDLLFGRRKTPEELLRQNQRALNRAMRELDRERQKLETQEKKIIADIKKMAKQGQMDAVR
10 20 30 40 50 60
50 60 70 80 90 100
pF1KE1 VYAENAIRKKNEGVNWLRMASRVDAVASKVQTAVTMKGVTKNMAQVTKALDKALSTMDLQ
..:.. .: . ... : . ..::. :.:: . ..... : ::::. . :
XP_005 IMAKDLVRTRRYVRKFVLMRANIQAVSLKIQTLKSNNSMAQAMKGVTKAMGTMNRQLKLP
70 80 90 100 110 120
110 120 130 140 150 160
pF1KE1 KVSSVMDRFEQQVQNLDVHTSVMEDSMSSATTLTTPQEQVDSLIMQIAEENGLEVLDQLS
.....: .::.:.. .:.. .:.:....: .:. :... :. .: :: . :.::
XP_005 QIQKIMMEFERQAEIMDMKEEMMNDAIDDAMGDEEDEEESDAVVSQVLDELGLSLTDELS
130 140 150 160 170 180
170 180 190
pF1KE1 QLPEGASAVGESSVRSQEDQLSRRLAALRN
XP_005 SECSKSWTPFPTQGPATAPSPPFPCITPLRCLTPPAQTPTFSADLPSTGGSLSVAAGGKK
190 200 210 220 230 240
>>NP_054762 (OMIM: 600795,609512,614696) charged multive (213 aa)
initn: 152 init1: 57 opt: 179 Z-score: 193.8 bits: 42.8 E(85289): 0.00047
Smith-Waterman score: 191; 17.8% identity (63.9% similar) in 191 aa overlap (7-194:20-210)
10 20 30 40
pF1KE1 MDDTLFQLKFTAKQLEKLAKKAEKDSKAEQAKVKKALLQKNVECARV
.:. : . . . ::. : . ..:: : : .:
NP_054 MASLFKKKTVDDVIKEQNRELRGTQRAIIRDRAALEKQEKQLELEIKKMAKIGNKEACKV
10 20 30 40 50 60
50 60 70 80 90 100
pF1KE1 YAENAIRKKNEGVNWLRMASRVDAVASKVQTAVTMKGVTKNMAQVTKALDKALSTMDLQK
:.. .. ... . . ..:.: ........ .. .. :. ..:... . . :: ::
NP_054 LAKQLVHLRKQKTRTFAVSSKVTSMSTQTKVMNSQMKMAGAMSTTAKTMQAVNKKMDPQK
70 80 90 100 110 120
110 120 130 140 150 160
pF1KE1 VSSVMDRFEQQVQNLDVHTSVMEDSMSSATTLTTPQEQVDSLIMQIAEENGLEVLDQLSQ
. ..:. :... ..... ...:.... . .:. .... :. .: :.:. ....
NP_054 TLQTMQNFQKENMKMEMTEEMINDTLDDIFDGSDDEEESQDIVNQVLDEIGIEISGKMAK
130 140 150 160 170 180
170 180 190
pF1KE1 LPEGASAVGESSVRS---QEDQLSRRLAALRN
: .: .. .:. . ..... :.: ::
NP_054 APSAARSLPSASTSKATISDEEIERQLKALGVD
190 200 210
>>XP_011531878 (OMIM: 600795,609512,614696) PREDICTED: c (229 aa)
initn: 128 init1: 57 opt: 179 Z-score: 193.3 bits: 42.8 E(85289): 0.0005
Smith-Waterman score: 191; 17.8% identity (63.9% similar) in 191 aa overlap (7-194:36-226)
10 20 30
pF1KE1 MDDTLFQLKFTAKQLEKLAKKAEKDSKAEQAKVKKA
.:. : . . . ::. : . ..::
XP_011 RNHHLPDSSDSSTSAYRVARITDVIKEQNRELRGTQRAIIRDRAALEKQEKQLELEIKKM
10 20 30 40 50 60
40 50 60 70 80 90
pF1KE1 LLQKNVECARVYAENAIRKKNEGVNWLRMASRVDAVASKVQTAVTMKGVTKNMAQVTKAL
: : .: :.. .. ... . . ..:.: ........ .. .. :. ..:..
XP_011 AKIGNKEACKVLAKQLVHLRKQKTRTFAVSSKVTSMSTQTKVMNSQMKMAGAMSTTAKTM
70 80 90 100 110 120
100 110 120 130 140 150
pF1KE1 DKALSTMDLQKVSSVMDRFEQQVQNLDVHTSVMEDSMSSATTLTTPQEQVDSLIMQIAEE
. . . :: ::. ..:. :... ..... ...:.... . .:. .... :. .:
XP_011 QAVNKKMDPQKTLQTMQNFQKENMKMEMTEEMINDTLDDIFDGSDDEEESQDIVNQVLDE
130 140 150 160 170 180
160 170 180 190
pF1KE1 NGLEVLDQLSQLPEGASAVGESSVRS---QEDQLSRRLAALRN
:.:. .... : .: .. .:. . ..... :.: ::
XP_011 IGIEISGKMAKAPSAARSLPSASTSKATISDEEIERQLKALGVD
190 200 210 220
>>NP_001231573 (OMIM: 600795,609512,614696) charged mult (172 aa)
initn: 141 init1: 57 opt: 163 Z-score: 179.3 bits: 39.8 E(85289): 0.003
Smith-Waterman score: 175; 17.5% identity (66.3% similar) in 166 aa overlap (32-194:4-169)
10 20 30 40 50 60
pF1KE1 DDTLFQLKFTAKQLEKLAKKAEKDSKAEQAKVKKALLQKNVECARVYAENAIRKKNEGVN
..:: : : .: :.. .. ... .
NP_001 MELEIKKMAKIGNKEACKVLAKQLVHLRKQKTR
10 20 30
70 80 90 100 110 120
pF1KE1 WLRMASRVDAVASKVQTAVTMKGVTKNMAQVTKALDKALSTMDLQKVSSVMDRFEQQVQN
. ..:.: ........ .. .. :. ..:... . . :: ::. ..:. :... ..
NP_001 TFAVSSKVTSMSTQTKVMNSQMKMAGAMSTTAKTMQAVNKKMDPQKTLQTMQNFQKENMK
40 50 60 70 80 90
130 140 150 160 170 180
pF1KE1 LDVHTSVMEDSMSSATTLTTPQEQVDSLIMQIAEENGLEVLDQLSQLPEGASAVGESSVR
... ...:.... . .:. .... :. .: :.:. .... : .: .. .:.
NP_001 MEMTEEMINDTLDDIFDGSDDEEESQDIVNQVLDEIGIEISGKMAKAPSAARSLPSASTS
100 110 120 130 140 150
190
pF1KE1 S---QEDQLSRRLAALRN
. ..... :.: ::
NP_001 KATISDEEIERQLKALGVD
160 170
196 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sat Nov 5 13:22:52 2016 done: Sat Nov 5 13:22:53 2016
Total Scan time: 5.530 Total Display time: -0.010
Function used was FASTA [36.3.4 Apr, 2011]