FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE1402, 599 aa 1>>>pF1KE1402 599 - 599 aa - 599 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.0429+/-0.000368; mu= 15.5360+/- 0.023 mean_var=93.7326+/-18.091, 0's: 0 Z-trim(115.4): 187 B-trim: 38 in 1/56 Lambda= 0.132473 statistics sampled from 25598 (25804) to 25598 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.668), E-opt: 0.2 (0.303), width: 16 Scan time: 10.870 The best scores are: opt bits E(85289) NP_000953 (OMIM: 176805) prostaglandin G/H synthas ( 599) 4161 805.9 0 XP_011517177 (OMIM: 176805) PREDICTED: prostagland ( 574) 3969 769.2 0 XP_005252162 (OMIM: 176805) PREDICTED: prostagland ( 574) 3969 769.2 0 XP_016870418 (OMIM: 176805) PREDICTED: prostagland ( 574) 3969 769.2 0 XP_011517178 (OMIM: 176805) PREDICTED: prostagland ( 490) 3353 651.4 2e-186 NP_001258094 (OMIM: 176805) prostaglandin G/H synt ( 490) 3353 651.4 2e-186 NP_001258093 (OMIM: 176805) prostaglandin G/H synt ( 551) 2980 580.2 6.3e-165 NP_542158 (OMIM: 176805) prostaglandin G/H synthas ( 562) 2799 545.6 1.7e-154 NP_000954 (OMIM: 600262) prostaglandin G/H synthas ( 604) 2660 519.0 1.8e-146 NP_001258297 (OMIM: 176805) prostaglandin G/H synt ( 537) 2607 508.9 1.8e-143 NP_001258296 (OMIM: 176805) prostaglandin G/H synt ( 453) 1991 391.1 4.3e-108 NP_001258095 (OMIM: 176805) prostaglandin G/H synt ( 453) 1991 391.1 4.3e-108 >>NP_000953 (OMIM: 176805) prostaglandin G/H synthase 1 (599 aa) initn: 4161 init1: 4161 opt: 4161 Z-score: 4301.2 bits: 805.9 E(85289): 0 Smith-Waterman score: 4161; 99.8% identity (99.8% similar) in 599 aa overlap (1-599:1-599) 10 20 30 40 50 60 pF1KE1 MSRSLLLRFLLFLLLLPPLPVLLADPGAPTPVNPCCYYPCQHQGICVRFGLDRYQCDCTR ::::::: :::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 MSRSLLLWFLLFLLLLPPLPVLLADPGAPTPVNPCCYYPCQHQGICVRFGLDRYQCDCTR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 TGYSGPNCTIPGLWTWLRNSLRPSPSFTHFLLTHGRWFWEFVNATFIREMLMRLVLTVRS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 TGYSGPNCTIPGLWTWLRNSLRPSPSFTHFLLTHGRWFWEFVNATFIREMLMRLVLTVRS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 NLIPSPPTYNSAHDYISWESFSNVSYYTRILPSVPKDCPTPMGTKGKKQLPDAQLLARRF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 NLIPSPPTYNSAHDYISWESFSNVSYYTRILPSVPKDCPTPMGTKGKKQLPDAQLLARRF 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 LLRRKFIPDPQGTNLMFAFFAQHFTHQFFKTSGKMGPGFTKALGHGVDLGHIYGDNLERQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 LLRRKFIPDPQGTNLMFAFFAQHFTHQFFKTSGKMGPGFTKALGHGVDLGHIYGDNLERQ 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE1 YQLRLFKDGKLKYQVLDGEMYPPSVEEAPVLMHYPRGIPPQSQMAVGQEVFGLLPGLMLY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 YQLRLFKDGKLKYQVLDGEMYPPSVEEAPVLMHYPRGIPPQSQMAVGQEVFGLLPGLMLY 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE1 ATLWLREHNRVCDLLKAEHPTWGDEQLFQTTRLILIGETIKIVIEEYVQQLSGYFLQLKF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 ATLWLREHNRVCDLLKAEHPTWGDEQLFQTTRLILIGETIKIVIEEYVQQLSGYFLQLKF 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE1 DPELLFGVQFQYRNRIAMEFNHLYHWHPLMPDSFKVGSQEYSYEQFLFNTSMLVDYGVEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 DPELLFGVQFQYRNRIAMEFNHLYHWHPLMPDSFKVGSQEYSYEQFLFNTSMLVDYGVEA 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE1 LVDAFSRQIAGRIGGGRNMDHHILHVAVDVIRESREMRLQPFNEYRKRFGMKPYTSFQEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 LVDAFSRQIAGRIGGGRNMDHHILHVAVDVIRESREMRLQPFNEYRKRFGMKPYTSFQEL 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE1 VGEKEMAAELEELYGDIDALEFYPGLLLEKCHPNSIFGESMIEIGAPFSLKGLLGNPICS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 VGEKEMAAELEELYGDIDALEFYPGLLLEKCHPNSIFGESMIEIGAPFSLKGLLGNPICS 490 500 510 520 530 540 550 560 570 580 590 pF1KE1 PEYWKPSTFGGEVGFNIVKTATLKKLVCLNTKTCPYVSFRVPDASQDDGPAVERPSTEL ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 PEYWKPSTFGGEVGFNIVKTATLKKLVCLNTKTCPYVSFRVPDASQDDGPAVERPSTEL 550 560 570 580 590 >>XP_011517177 (OMIM: 176805) PREDICTED: prostaglandin G (574 aa) initn: 3964 init1: 3964 opt: 3969 Z-score: 4103.2 bits: 769.2 E(85289): 0 Smith-Waterman score: 3969; 99.5% identity (99.6% similar) in 571 aa overlap (29-599:4-574) 10 20 30 40 50 60 pF1KE1 MSRSLLLRFLLFLLLLPPLPVLLADPGAPTPVNPCCYYPCQHQGICVRFGLDRYQCDCTR : .:::::::::::::::::::::::::::: XP_011 MRKPRLMNPCCYYPCQHQGICVRFGLDRYQCDCTR 10 20 30 70 80 90 100 110 120 pF1KE1 TGYSGPNCTIPGLWTWLRNSLRPSPSFTHFLLTHGRWFWEFVNATFIREMLMRLVLTVRS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TGYSGPNCTIPGLWTWLRNSLRPSPSFTHFLLTHGRWFWEFVNATFIREMLMRLVLTVRS 40 50 60 70 80 90 130 140 150 160 170 180 pF1KE1 NLIPSPPTYNSAHDYISWESFSNVSYYTRILPSVPKDCPTPMGTKGKKQLPDAQLLARRF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NLIPSPPTYNSAHDYISWESFSNVSYYTRILPSVPKDCPTPMGTKGKKQLPDAQLLARRF 100 110 120 130 140 150 190 200 210 220 230 240 pF1KE1 LLRRKFIPDPQGTNLMFAFFAQHFTHQFFKTSGKMGPGFTKALGHGVDLGHIYGDNLERQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LLRRKFIPDPQGTNLMFAFFAQHFTHQFFKTSGKMGPGFTKALGHGVDLGHIYGDNLERQ 160 170 180 190 200 210 250 260 270 280 290 300 pF1KE1 YQLRLFKDGKLKYQVLDGEMYPPSVEEAPVLMHYPRGIPPQSQMAVGQEVFGLLPGLMLY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 YQLRLFKDGKLKYQVLDGEMYPPSVEEAPVLMHYPRGIPPQSQMAVGQEVFGLLPGLMLY 220 230 240 250 260 270 310 320 330 340 350 360 pF1KE1 ATLWLREHNRVCDLLKAEHPTWGDEQLFQTTRLILIGETIKIVIEEYVQQLSGYFLQLKF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ATLWLREHNRVCDLLKAEHPTWGDEQLFQTTRLILIGETIKIVIEEYVQQLSGYFLQLKF 280 290 300 310 320 330 370 380 390 400 410 420 pF1KE1 DPELLFGVQFQYRNRIAMEFNHLYHWHPLMPDSFKVGSQEYSYEQFLFNTSMLVDYGVEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DPELLFGVQFQYRNRIAMEFNHLYHWHPLMPDSFKVGSQEYSYEQFLFNTSMLVDYGVEA 340 350 360 370 380 390 430 440 450 460 470 480 pF1KE1 LVDAFSRQIAGRIGGGRNMDHHILHVAVDVIRESREMRLQPFNEYRKRFGMKPYTSFQEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LVDAFSRQIAGRIGGGRNMDHHILHVAVDVIRESREMRLQPFNEYRKRFGMKPYTSFQEL 400 410 420 430 440 450 490 500 510 520 530 540 pF1KE1 VGEKEMAAELEELYGDIDALEFYPGLLLEKCHPNSIFGESMIEIGAPFSLKGLLGNPICS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VGEKEMAAELEELYGDIDALEFYPGLLLEKCHPNSIFGESMIEIGAPFSLKGLLGNPICS 460 470 480 490 500 510 550 560 570 580 590 pF1KE1 PEYWKPSTFGGEVGFNIVKTATLKKLVCLNTKTCPYVSFRVPDASQDDGPAVERPSTEL ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PEYWKPSTFGGEVGFNIVKTATLKKLVCLNTKTCPYVSFRVPDASQDDGPAVERPSTEL 520 530 540 550 560 570 >>XP_005252162 (OMIM: 176805) PREDICTED: prostaglandin G (574 aa) initn: 3964 init1: 3964 opt: 3969 Z-score: 4103.2 bits: 769.2 E(85289): 0 Smith-Waterman score: 3969; 99.5% identity (99.6% similar) in 571 aa overlap (29-599:4-574) 10 20 30 40 50 60 pF1KE1 MSRSLLLRFLLFLLLLPPLPVLLADPGAPTPVNPCCYYPCQHQGICVRFGLDRYQCDCTR : .:::::::::::::::::::::::::::: XP_005 MRKPRLMNPCCYYPCQHQGICVRFGLDRYQCDCTR 10 20 30 70 80 90 100 110 120 pF1KE1 TGYSGPNCTIPGLWTWLRNSLRPSPSFTHFLLTHGRWFWEFVNATFIREMLMRLVLTVRS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TGYSGPNCTIPGLWTWLRNSLRPSPSFTHFLLTHGRWFWEFVNATFIREMLMRLVLTVRS 40 50 60 70 80 90 130 140 150 160 170 180 pF1KE1 NLIPSPPTYNSAHDYISWESFSNVSYYTRILPSVPKDCPTPMGTKGKKQLPDAQLLARRF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 NLIPSPPTYNSAHDYISWESFSNVSYYTRILPSVPKDCPTPMGTKGKKQLPDAQLLARRF 100 110 120 130 140 150 190 200 210 220 230 240 pF1KE1 LLRRKFIPDPQGTNLMFAFFAQHFTHQFFKTSGKMGPGFTKALGHGVDLGHIYGDNLERQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LLRRKFIPDPQGTNLMFAFFAQHFTHQFFKTSGKMGPGFTKALGHGVDLGHIYGDNLERQ 160 170 180 190 200 210 250 260 270 280 290 300 pF1KE1 YQLRLFKDGKLKYQVLDGEMYPPSVEEAPVLMHYPRGIPPQSQMAVGQEVFGLLPGLMLY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 YQLRLFKDGKLKYQVLDGEMYPPSVEEAPVLMHYPRGIPPQSQMAVGQEVFGLLPGLMLY 220 230 240 250 260 270 310 320 330 340 350 360 pF1KE1 ATLWLREHNRVCDLLKAEHPTWGDEQLFQTTRLILIGETIKIVIEEYVQQLSGYFLQLKF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ATLWLREHNRVCDLLKAEHPTWGDEQLFQTTRLILIGETIKIVIEEYVQQLSGYFLQLKF 280 290 300 310 320 330 370 380 390 400 410 420 pF1KE1 DPELLFGVQFQYRNRIAMEFNHLYHWHPLMPDSFKVGSQEYSYEQFLFNTSMLVDYGVEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DPELLFGVQFQYRNRIAMEFNHLYHWHPLMPDSFKVGSQEYSYEQFLFNTSMLVDYGVEA 340 350 360 370 380 390 430 440 450 460 470 480 pF1KE1 LVDAFSRQIAGRIGGGRNMDHHILHVAVDVIRESREMRLQPFNEYRKRFGMKPYTSFQEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LVDAFSRQIAGRIGGGRNMDHHILHVAVDVIRESREMRLQPFNEYRKRFGMKPYTSFQEL 400 410 420 430 440 450 490 500 510 520 530 540 pF1KE1 VGEKEMAAELEELYGDIDALEFYPGLLLEKCHPNSIFGESMIEIGAPFSLKGLLGNPICS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VGEKEMAAELEELYGDIDALEFYPGLLLEKCHPNSIFGESMIEIGAPFSLKGLLGNPICS 460 470 480 490 500 510 550 560 570 580 590 pF1KE1 PEYWKPSTFGGEVGFNIVKTATLKKLVCLNTKTCPYVSFRVPDASQDDGPAVERPSTEL ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PEYWKPSTFGGEVGFNIVKTATLKKLVCLNTKTCPYVSFRVPDASQDDGPAVERPSTEL 520 530 540 550 560 570 >>XP_016870418 (OMIM: 176805) PREDICTED: prostaglandin G (574 aa) initn: 3964 init1: 3964 opt: 3969 Z-score: 4103.2 bits: 769.2 E(85289): 0 Smith-Waterman score: 3969; 99.5% identity (99.6% similar) in 571 aa overlap (29-599:4-574) 10 20 30 40 50 60 pF1KE1 MSRSLLLRFLLFLLLLPPLPVLLADPGAPTPVNPCCYYPCQHQGICVRFGLDRYQCDCTR : .:::::::::::::::::::::::::::: XP_016 MRKPRLMNPCCYYPCQHQGICVRFGLDRYQCDCTR 10 20 30 70 80 90 100 110 120 pF1KE1 TGYSGPNCTIPGLWTWLRNSLRPSPSFTHFLLTHGRWFWEFVNATFIREMLMRLVLTVRS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TGYSGPNCTIPGLWTWLRNSLRPSPSFTHFLLTHGRWFWEFVNATFIREMLMRLVLTVRS 40 50 60 70 80 90 130 140 150 160 170 180 pF1KE1 NLIPSPPTYNSAHDYISWESFSNVSYYTRILPSVPKDCPTPMGTKGKKQLPDAQLLARRF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NLIPSPPTYNSAHDYISWESFSNVSYYTRILPSVPKDCPTPMGTKGKKQLPDAQLLARRF 100 110 120 130 140 150 190 200 210 220 230 240 pF1KE1 LLRRKFIPDPQGTNLMFAFFAQHFTHQFFKTSGKMGPGFTKALGHGVDLGHIYGDNLERQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LLRRKFIPDPQGTNLMFAFFAQHFTHQFFKTSGKMGPGFTKALGHGVDLGHIYGDNLERQ 160 170 180 190 200 210 250 260 270 280 290 300 pF1KE1 YQLRLFKDGKLKYQVLDGEMYPPSVEEAPVLMHYPRGIPPQSQMAVGQEVFGLLPGLMLY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YQLRLFKDGKLKYQVLDGEMYPPSVEEAPVLMHYPRGIPPQSQMAVGQEVFGLLPGLMLY 220 230 240 250 260 270 310 320 330 340 350 360 pF1KE1 ATLWLREHNRVCDLLKAEHPTWGDEQLFQTTRLILIGETIKIVIEEYVQQLSGYFLQLKF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ATLWLREHNRVCDLLKAEHPTWGDEQLFQTTRLILIGETIKIVIEEYVQQLSGYFLQLKF 280 290 300 310 320 330 370 380 390 400 410 420 pF1KE1 DPELLFGVQFQYRNRIAMEFNHLYHWHPLMPDSFKVGSQEYSYEQFLFNTSMLVDYGVEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DPELLFGVQFQYRNRIAMEFNHLYHWHPLMPDSFKVGSQEYSYEQFLFNTSMLVDYGVEA 340 350 360 370 380 390 430 440 450 460 470 480 pF1KE1 LVDAFSRQIAGRIGGGRNMDHHILHVAVDVIRESREMRLQPFNEYRKRFGMKPYTSFQEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LVDAFSRQIAGRIGGGRNMDHHILHVAVDVIRESREMRLQPFNEYRKRFGMKPYTSFQEL 400 410 420 430 440 450 490 500 510 520 530 540 pF1KE1 VGEKEMAAELEELYGDIDALEFYPGLLLEKCHPNSIFGESMIEIGAPFSLKGLLGNPICS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VGEKEMAAELEELYGDIDALEFYPGLLLEKCHPNSIFGESMIEIGAPFSLKGLLGNPICS 460 470 480 490 500 510 550 560 570 580 590 pF1KE1 PEYWKPSTFGGEVGFNIVKTATLKKLVCLNTKTCPYVSFRVPDASQDDGPAVERPSTEL ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PEYWKPSTFGGEVGFNIVKTATLKKLVCLNTKTCPYVSFRVPDASQDDGPAVERPSTEL 520 530 540 550 560 570 >>XP_011517178 (OMIM: 176805) PREDICTED: prostaglandin G (490 aa) initn: 3353 init1: 3353 opt: 3353 Z-score: 3467.9 bits: 651.4 E(85289): 2e-186 Smith-Waterman score: 3353; 100.0% identity (100.0% similar) in 490 aa overlap (110-599:1-490) 80 90 100 110 120 130 pF1KE1 SLRPSPSFTHFLLTHGRWFWEFVNATFIREMLMRLVLTVRSNLIPSPPTYNSAHDYISWE :::::::::::::::::::::::::::::: XP_011 MLMRLVLTVRSNLIPSPPTYNSAHDYISWE 10 20 30 140 150 160 170 180 190 pF1KE1 SFSNVSYYTRILPSVPKDCPTPMGTKGKKQLPDAQLLARRFLLRRKFIPDPQGTNLMFAF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SFSNVSYYTRILPSVPKDCPTPMGTKGKKQLPDAQLLARRFLLRRKFIPDPQGTNLMFAF 40 50 60 70 80 90 200 210 220 230 240 250 pF1KE1 FAQHFTHQFFKTSGKMGPGFTKALGHGVDLGHIYGDNLERQYQLRLFKDGKLKYQVLDGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FAQHFTHQFFKTSGKMGPGFTKALGHGVDLGHIYGDNLERQYQLRLFKDGKLKYQVLDGE 100 110 120 130 140 150 260 270 280 290 300 310 pF1KE1 MYPPSVEEAPVLMHYPRGIPPQSQMAVGQEVFGLLPGLMLYATLWLREHNRVCDLLKAEH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MYPPSVEEAPVLMHYPRGIPPQSQMAVGQEVFGLLPGLMLYATLWLREHNRVCDLLKAEH 160 170 180 190 200 210 320 330 340 350 360 370 pF1KE1 PTWGDEQLFQTTRLILIGETIKIVIEEYVQQLSGYFLQLKFDPELLFGVQFQYRNRIAME :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PTWGDEQLFQTTRLILIGETIKIVIEEYVQQLSGYFLQLKFDPELLFGVQFQYRNRIAME 220 230 240 250 260 270 380 390 400 410 420 430 pF1KE1 FNHLYHWHPLMPDSFKVGSQEYSYEQFLFNTSMLVDYGVEALVDAFSRQIAGRIGGGRNM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FNHLYHWHPLMPDSFKVGSQEYSYEQFLFNTSMLVDYGVEALVDAFSRQIAGRIGGGRNM 280 290 300 310 320 330 440 450 460 470 480 490 pF1KE1 DHHILHVAVDVIRESREMRLQPFNEYRKRFGMKPYTSFQELVGEKEMAAELEELYGDIDA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DHHILHVAVDVIRESREMRLQPFNEYRKRFGMKPYTSFQELVGEKEMAAELEELYGDIDA 340 350 360 370 380 390 500 510 520 530 540 550 pF1KE1 LEFYPGLLLEKCHPNSIFGESMIEIGAPFSLKGLLGNPICSPEYWKPSTFGGEVGFNIVK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LEFYPGLLLEKCHPNSIFGESMIEIGAPFSLKGLLGNPICSPEYWKPSTFGGEVGFNIVK 400 410 420 430 440 450 560 570 580 590 pF1KE1 TATLKKLVCLNTKTCPYVSFRVPDASQDDGPAVERPSTEL :::::::::::::::::::::::::::::::::::::::: XP_011 TATLKKLVCLNTKTCPYVSFRVPDASQDDGPAVERPSTEL 460 470 480 490 >>NP_001258094 (OMIM: 176805) prostaglandin G/H synthase (490 aa) initn: 3353 init1: 3353 opt: 3353 Z-score: 3467.9 bits: 651.4 E(85289): 2e-186 Smith-Waterman score: 3353; 100.0% identity (100.0% similar) in 490 aa overlap (110-599:1-490) 80 90 100 110 120 130 pF1KE1 SLRPSPSFTHFLLTHGRWFWEFVNATFIREMLMRLVLTVRSNLIPSPPTYNSAHDYISWE :::::::::::::::::::::::::::::: NP_001 MLMRLVLTVRSNLIPSPPTYNSAHDYISWE 10 20 30 140 150 160 170 180 190 pF1KE1 SFSNVSYYTRILPSVPKDCPTPMGTKGKKQLPDAQLLARRFLLRRKFIPDPQGTNLMFAF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SFSNVSYYTRILPSVPKDCPTPMGTKGKKQLPDAQLLARRFLLRRKFIPDPQGTNLMFAF 40 50 60 70 80 90 200 210 220 230 240 250 pF1KE1 FAQHFTHQFFKTSGKMGPGFTKALGHGVDLGHIYGDNLERQYQLRLFKDGKLKYQVLDGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FAQHFTHQFFKTSGKMGPGFTKALGHGVDLGHIYGDNLERQYQLRLFKDGKLKYQVLDGE 100 110 120 130 140 150 260 270 280 290 300 310 pF1KE1 MYPPSVEEAPVLMHYPRGIPPQSQMAVGQEVFGLLPGLMLYATLWLREHNRVCDLLKAEH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MYPPSVEEAPVLMHYPRGIPPQSQMAVGQEVFGLLPGLMLYATLWLREHNRVCDLLKAEH 160 170 180 190 200 210 320 330 340 350 360 370 pF1KE1 PTWGDEQLFQTTRLILIGETIKIVIEEYVQQLSGYFLQLKFDPELLFGVQFQYRNRIAME :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PTWGDEQLFQTTRLILIGETIKIVIEEYVQQLSGYFLQLKFDPELLFGVQFQYRNRIAME 220 230 240 250 260 270 380 390 400 410 420 430 pF1KE1 FNHLYHWHPLMPDSFKVGSQEYSYEQFLFNTSMLVDYGVEALVDAFSRQIAGRIGGGRNM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FNHLYHWHPLMPDSFKVGSQEYSYEQFLFNTSMLVDYGVEALVDAFSRQIAGRIGGGRNM 280 290 300 310 320 330 440 450 460 470 480 490 pF1KE1 DHHILHVAVDVIRESREMRLQPFNEYRKRFGMKPYTSFQELVGEKEMAAELEELYGDIDA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DHHILHVAVDVIRESREMRLQPFNEYRKRFGMKPYTSFQELVGEKEMAAELEELYGDIDA 340 350 360 370 380 390 500 510 520 530 540 550 pF1KE1 LEFYPGLLLEKCHPNSIFGESMIEIGAPFSLKGLLGNPICSPEYWKPSTFGGEVGFNIVK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LEFYPGLLLEKCHPNSIFGESMIEIGAPFSLKGLLGNPICSPEYWKPSTFGGEVGFNIVK 400 410 420 430 440 450 560 570 580 590 pF1KE1 TATLKKLVCLNTKTCPYVSFRVPDASQDDGPAVERPSTEL :::::::::::::::::::::::::::::::::::::::: NP_001 TATLKKLVCLNTKTCPYVSFRVPDASQDDGPAVERPSTEL 460 470 480 490 >>NP_001258093 (OMIM: 176805) prostaglandin G/H synthase (551 aa) initn: 2970 init1: 2970 opt: 2980 Z-score: 3081.9 bits: 580.2 E(85289): 6.3e-165 Smith-Waterman score: 3718; 91.8% identity (91.8% similar) in 599 aa overlap (1-599:1-551) 10 20 30 40 50 60 pF1KE1 MSRSLLLRFLLFLLLLPPLPVLLADPGAPTPVNPCCYYPCQHQGICVRFGLDRYQCDCTR ::::::: :::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MSRSLLLWFLLFLLLLPPLPVLLADPGAPTPVNPCCYYPCQHQGICVRFGLDRYQCDCTR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 TGYSGPNCTIPGLWTWLRNSLRPSPSFTHFLLTHGRWFWEFVNATFIREMLMRLVLTVRS ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TGYSGPNCTIPGLWTWLRNSLRPSPSFTHFLLTHGRWFWEFVNATFIREMLMRLVLT--- 70 80 90 100 110 130 140 150 160 170 180 pF1KE1 NLIPSPPTYNSAHDYISWESFSNVSYYTRILPSVPKDCPTPMGTKGKKQLPDAQLLARRF ::::::::::::::: NP_001 ---------------------------------------------GKKQLPDAQLLARRF 120 130 190 200 210 220 230 240 pF1KE1 LLRRKFIPDPQGTNLMFAFFAQHFTHQFFKTSGKMGPGFTKALGHGVDLGHIYGDNLERQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LLRRKFIPDPQGTNLMFAFFAQHFTHQFFKTSGKMGPGFTKALGHGVDLGHIYGDNLERQ 140 150 160 170 180 190 250 260 270 280 290 300 pF1KE1 YQLRLFKDGKLKYQVLDGEMYPPSVEEAPVLMHYPRGIPPQSQMAVGQEVFGLLPGLMLY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YQLRLFKDGKLKYQVLDGEMYPPSVEEAPVLMHYPRGIPPQSQMAVGQEVFGLLPGLMLY 200 210 220 230 240 250 310 320 330 340 350 360 pF1KE1 ATLWLREHNRVCDLLKAEHPTWGDEQLFQTTRLILIGETIKIVIEEYVQQLSGYFLQLKF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ATLWLREHNRVCDLLKAEHPTWGDEQLFQTTRLILIGETIKIVIEEYVQQLSGYFLQLKF 260 270 280 290 300 310 370 380 390 400 410 420 pF1KE1 DPELLFGVQFQYRNRIAMEFNHLYHWHPLMPDSFKVGSQEYSYEQFLFNTSMLVDYGVEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DPELLFGVQFQYRNRIAMEFNHLYHWHPLMPDSFKVGSQEYSYEQFLFNTSMLVDYGVEA 320 330 340 350 360 370 430 440 450 460 470 480 pF1KE1 LVDAFSRQIAGRIGGGRNMDHHILHVAVDVIRESREMRLQPFNEYRKRFGMKPYTSFQEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LVDAFSRQIAGRIGGGRNMDHHILHVAVDVIRESREMRLQPFNEYRKRFGMKPYTSFQEL 380 390 400 410 420 430 490 500 510 520 530 540 pF1KE1 VGEKEMAAELEELYGDIDALEFYPGLLLEKCHPNSIFGESMIEIGAPFSLKGLLGNPICS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VGEKEMAAELEELYGDIDALEFYPGLLLEKCHPNSIFGESMIEIGAPFSLKGLLGNPICS 440 450 460 470 480 490 550 560 570 580 590 pF1KE1 PEYWKPSTFGGEVGFNIVKTATLKKLVCLNTKTCPYVSFRVPDASQDDGPAVERPSTEL ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PEYWKPSTFGGEVGFNIVKTATLKKLVCLNTKTCPYVSFRVPDASQDDGPAVERPSTEL 500 510 520 530 540 550 >>NP_542158 (OMIM: 176805) prostaglandin G/H synthase 1 (562 aa) initn: 2799 init1: 2799 opt: 2799 Z-score: 2894.8 bits: 545.6 E(85289): 1.7e-154 Smith-Waterman score: 3842; 93.7% identity (93.7% similar) in 599 aa overlap (1-599:1-562) 10 20 30 40 50 60 pF1KE1 MSRSLLLRFLLFLLLLPPLPVLLADPGAPTPVNPCCYYPCQHQGICVRFGLDRYQCDCTR ::::::: :::::::::::::::::::::::::::::::::::::::::::::::::::: NP_542 MSRSLLLWFLLFLLLLPPLPVLLADPGAPTPVNPCCYYPCQHQGICVRFGLDRYQCDCTR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 TGYSGPNCTIPGLWTWLRNSLRPSPSFTHFLLTHGRWFWEFVNATFIREMLMRLVLTVRS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_542 TGYSGPNCTIPGLWTWLRNSLRPSPSFTHFLLTHGRWFWEFVNATFIREMLMRLVLTVRS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 NLIPSPPTYNSAHDYISWESFSNVSYYTRILPSVPKDCPTPMGTKGKKQLPDAQLLARRF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_542 NLIPSPPTYNSAHDYISWESFSNVSYYTRILPSVPKDCPTPMGTKGKKQLPDAQLLARRF 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 LLRRKFIPDPQGTNLMFAFFAQHFTHQFFKTSGKMGPGFTKALGHGVDLGHIYGDNLERQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_542 LLRRKFIPDPQGTNLMFAFFAQHFTHQFFKTSGKMGPGFTKALGHGVDLGHIYGDNLERQ 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE1 YQLRLFKDGKLKYQVLDGEMYPPSVEEAPVLMHYPRGIPPQSQMAVGQEVFGLLPGLMLY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_542 YQLRLFKDGKLKYQVLDGEMYPPSVEEAPVLMHYPRGIPPQSQMAVGQEVFGLLPGLMLY 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE1 ATLWLREHNRVCDLLKAEHPTWGDEQLFQTTRLILIGETIKIVIEEYVQQLSGYFLQLKF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_542 ATLWLREHNRVCDLLKAEHPTWGDEQLFQTTRLILIGETIKIVIEEYVQQLSGYFLQLKF 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE1 DPELLFGVQFQYRNRIAMEFNHLYHWHPLMPDSFKVGSQEYSYEQFLFNTSMLVDYGVEA ::::::::::::::::::::::::::::::::::: NP_542 DPELLFGVQFQYRNRIAMEFNHLYHWHPLMPDSFK------------------------- 370 380 390 430 440 450 460 470 480 pF1KE1 LVDAFSRQIAGRIGGGRNMDHHILHVAVDVIRESREMRLQPFNEYRKRFGMKPYTSFQEL :::::::::::::::::::::::::::::::::::::::::::::::: NP_542 ------------IGGGRNMDHHILHVAVDVIRESREMRLQPFNEYRKRFGMKPYTSFQEL 400 410 420 430 440 490 500 510 520 530 540 pF1KE1 VGEKEMAAELEELYGDIDALEFYPGLLLEKCHPNSIFGESMIEIGAPFSLKGLLGNPICS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_542 VGEKEMAAELEELYGDIDALEFYPGLLLEKCHPNSIFGESMIEIGAPFSLKGLLGNPICS 450 460 470 480 490 500 550 560 570 580 590 pF1KE1 PEYWKPSTFGGEVGFNIVKTATLKKLVCLNTKTCPYVSFRVPDASQDDGPAVERPSTEL ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_542 PEYWKPSTFGGEVGFNIVKTATLKKLVCLNTKTCPYVSFRVPDASQDDGPAVERPSTEL 510 520 530 540 550 560 >>NP_000954 (OMIM: 600262) prostaglandin G/H synthase 2 (604 aa) initn: 2362 init1: 2362 opt: 2660 Z-score: 2750.8 bits: 519.0 E(85289): 1.8e-146 Smith-Waterman score: 2660; 64.7% identity (87.5% similar) in 552 aa overlap (33-583:19-570) 10 20 30 40 50 60 pF1KE1 RSLLLRFLLFLLLLPPLPVLLADPGAPTPVNPCCYYPCQHQGICVRFGLDRYQCDCTRTG :::: .:::..:.:. :.:.:.::::::: NP_000 MLARALLLCAVLALSHTANPCCSHPCQNRGVCMSVGFDQYKCDCTRTG 10 20 30 40 70 80 90 100 110 120 pF1KE1 YSGPNCTIPGLWTWLRNSLRPSPSFTHFLLTHGRWFWEFVNAT-FIREMLMRLVLTVRSN . : ::. : . : .. :.:.:. .:..::: . ::. :: :.:. .: ::: ::. NP_000 FYGENCSTPEFLTRIKLFLKPTPNTVHYILTHFKGFWNVVNNIPFLRNAIMSYVLTSRSH 50 60 70 80 90 100 130 140 150 160 170 180 pF1KE1 LIPSPPTYNSAHDYISWESFSNVSYYTRILPSVPKDCPTPMGTKGKKQLPDAQLLARRFL :: ::::::. . : :::.:::.::::: :: :: :::::.:.::::::::.. .....: NP_000 LIDSPPTYNADYGYKSWEAFSNLSYYTRALPPVPDDCPTPLGVKGKKQLPDSNEIVEKLL 110 120 130 140 150 160 190 200 210 220 230 240 pF1KE1 LRRKFIPDPQGTNLMFAFFAQHFTHQFFKTSGKMGPGFTKALGHGVDLGHIYGDNLERQY :::::::::::.:.::::::::::::::::. : ::.::..:::::::.::::..: :: NP_000 LRRKFIPDPQGSNMMFAFFAQHFTHQFFKTDHKRGPAFTNGLGHGVDLNHIYGETLARQR 170 180 190 200 210 220 250 260 270 280 290 300 pF1KE1 QLRLFKDGKLKYQVLDGEMYPPSVEEAPVLMHYPRGIPPQSQMAVGQEVFGLLPGLMLYA .::::::::.:::..:::::::.:... . : :: .: . ..:::::::::.::::.:: NP_000 KLRLFKDGKMKYQIIDGEMYPPTVKDTQAEMIYPPQVPEHLRFAVGQEVFGLVPGLMMYA 230 240 250 260 270 280 310 320 330 340 350 360 pF1KE1 TLWLREHNRVCDLLKAEHPTWGDEQLFQTTRLILIGETIKIVIEEYVQQLSGYFLQLKFD :.::::::::::.:: ::: :::::::::.::::::::::::::.:::.:::: ..:::: NP_000 TIWLREHNRVCDVLKQEHPEWGDEQLFQTSRLILIGETIKIVIEDYVQHLSGYHFKLKFD 290 300 310 320 330 340 370 380 390 400 410 420 pF1KE1 PELLFGVQFQYRNRIAMEFNHLYHWHPLMPDSFKVGSQEYSYEQFLFNTSMLVDYGVEAL :::::. ::::.:::: ::: :::::::.::.:.. .:.:.:.::..:.:.:...:. . NP_000 PELLFNKQFQYQNRIAAEFNTLYHWHPLLPDTFQIHDQKYNYQQFIYNNSILLEHGITQF 350 360 370 380 390 400 430 440 450 460 470 480 pF1KE1 VDAFSRQIAGRIGGGRNMDHHILHVAVDVIRESREMRLQPFNEYRKRFGMKPYTSFQELV :..:.::::::..::::. . .:. : .::.:. : :::::::: .::: ::.::. NP_000 VESFTRQIAGRVAGGRNVPPAVQKVSQASIDQSRQMKYQSFNEYRKRFMLKPYESFEELT 410 420 430 440 450 460 490 500 510 520 530 540 pF1KE1 GEKEMAAELEELYGDIDALEFYPGLLLEKCHPNSIFGESMIEIGAPFSLKGLLGNPICSP :::::.:::: :::::::.:.::.::.:: .:..::::.:.:.:::::::::.:: :::: NP_000 GEKEMSAELEALYGDIDAVELYPALLVEKPRPDAIFGETMVEVGAPFSLKGLMGNVICSP 470 480 490 500 510 520 550 560 570 580 590 pF1KE1 EYWKPSTFGGEVGFNIVKTATLKKLVCLNTKTCPYVSFRVPDASQDDGPAVERPSTEL :::::::::::::.:..::....:.: :.: ::..:: ::: NP_000 AYWKPSTFGGEVGFQIINTASIQSLICNNVKGCPFTSFSVPDPELIKTVTINASSSRSGL 530 540 550 560 570 580 NP_000 DDINPTVLLKERSTEL 590 600 >>NP_001258297 (OMIM: 176805) prostaglandin G/H synthase (537 aa) initn: 2601 init1: 2601 opt: 2607 Z-score: 2696.8 bits: 508.9 E(85289): 1.8e-143 Smith-Waterman score: 3650; 93.0% identity (93.2% similar) in 571 aa overlap (29-599:4-537) 10 20 30 40 50 60 pF1KE1 MSRSLLLRFLLFLLLLPPLPVLLADPGAPTPVNPCCYYPCQHQGICVRFGLDRYQCDCTR : .:::::::::::::::::::::::::::: NP_001 MRKPRLMNPCCYYPCQHQGICVRFGLDRYQCDCTR 10 20 30 70 80 90 100 110 120 pF1KE1 TGYSGPNCTIPGLWTWLRNSLRPSPSFTHFLLTHGRWFWEFVNATFIREMLMRLVLTVRS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TGYSGPNCTIPGLWTWLRNSLRPSPSFTHFLLTHGRWFWEFVNATFIREMLMRLVLTVRS 40 50 60 70 80 90 130 140 150 160 170 180 pF1KE1 NLIPSPPTYNSAHDYISWESFSNVSYYTRILPSVPKDCPTPMGTKGKKQLPDAQLLARRF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NLIPSPPTYNSAHDYISWESFSNVSYYTRILPSVPKDCPTPMGTKGKKQLPDAQLLARRF 100 110 120 130 140 150 190 200 210 220 230 240 pF1KE1 LLRRKFIPDPQGTNLMFAFFAQHFTHQFFKTSGKMGPGFTKALGHGVDLGHIYGDNLERQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LLRRKFIPDPQGTNLMFAFFAQHFTHQFFKTSGKMGPGFTKALGHGVDLGHIYGDNLERQ 160 170 180 190 200 210 250 260 270 280 290 300 pF1KE1 YQLRLFKDGKLKYQVLDGEMYPPSVEEAPVLMHYPRGIPPQSQMAVGQEVFGLLPGLMLY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YQLRLFKDGKLKYQVLDGEMYPPSVEEAPVLMHYPRGIPPQSQMAVGQEVFGLLPGLMLY 220 230 240 250 260 270 310 320 330 340 350 360 pF1KE1 ATLWLREHNRVCDLLKAEHPTWGDEQLFQTTRLILIGETIKIVIEEYVQQLSGYFLQLKF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ATLWLREHNRVCDLLKAEHPTWGDEQLFQTTRLILIGETIKIVIEEYVQQLSGYFLQLKF 280 290 300 310 320 330 370 380 390 400 410 420 pF1KE1 DPELLFGVQFQYRNRIAMEFNHLYHWHPLMPDSFKVGSQEYSYEQFLFNTSMLVDYGVEA ::::::::::::::::::::::::::::::::::: NP_001 DPELLFGVQFQYRNRIAMEFNHLYHWHPLMPDSFK------------------------- 340 350 360 370 430 440 450 460 470 480 pF1KE1 LVDAFSRQIAGRIGGGRNMDHHILHVAVDVIRESREMRLQPFNEYRKRFGMKPYTSFQEL :::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ------------IGGGRNMDHHILHVAVDVIRESREMRLQPFNEYRKRFGMKPYTSFQEL 380 390 400 410 490 500 510 520 530 540 pF1KE1 VGEKEMAAELEELYGDIDALEFYPGLLLEKCHPNSIFGESMIEIGAPFSLKGLLGNPICS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VGEKEMAAELEELYGDIDALEFYPGLLLEKCHPNSIFGESMIEIGAPFSLKGLLGNPICS 420 430 440 450 460 470 550 560 570 580 590 pF1KE1 PEYWKPSTFGGEVGFNIVKTATLKKLVCLNTKTCPYVSFRVPDASQDDGPAVERPSTEL ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PEYWKPSTFGGEVGFNIVKTATLKKLVCLNTKTCPYVSFRVPDASQDDGPAVERPSTEL 480 490 500 510 520 530 599 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 22:30:37 2016 done: Sun Nov 6 22:30:38 2016 Total Scan time: 10.870 Total Display time: 0.130 Function used was FASTA [36.3.4 Apr, 2011]