FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE1326, 574 aa 1>>>pF1KE1326 574 - 574 aa - 574 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.6771+/-0.000422; mu= 16.3048+/- 0.026 mean_var=65.8786+/-12.890, 0's: 0 Z-trim(110.7): 25 B-trim: 5 in 1/51 Lambda= 0.158016 statistics sampled from 19045 (19068) to 19045 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.586), E-opt: 0.2 (0.224), width: 16 Scan time: 9.080 The best scores are: opt bits E(85289) NP_000289 (OMIM: 102900,266200,609712) pyruvate ki ( 574) 3703 853.6 0 NP_870986 (OMIM: 102900,266200,609712) pyruvate ki ( 543) 3497 806.6 0 XP_011507942 (OMIM: 102900,266200,609712) PREDICTE ( 510) 3297 761.0 0 XP_006711449 (OMIM: 102900,266200,609712) PREDICTE ( 510) 3297 761.0 0 XP_005254500 (OMIM: 179050) PREDICTED: pyruvate ki ( 591) 2559 592.8 1.1e-168 XP_006720633 (OMIM: 179050) PREDICTED: pyruvate ki ( 605) 2559 592.8 1.1e-168 XP_011519972 (OMIM: 179050) PREDICTED: pyruvate ki ( 566) 2551 590.9 3.6e-168 XP_005254502 (OMIM: 179050) PREDICTED: pyruvate ki ( 531) 2547 590.0 6.4e-168 NP_002645 (OMIM: 179050) pyruvate kinase PKM isofo ( 531) 2547 590.0 6.4e-168 NP_001193725 (OMIM: 179050) pyruvate kinase PKM is ( 605) 2492 577.5 4.3e-164 NP_001193728 (OMIM: 179050) pyruvate kinase PKM is ( 536) 2485 575.9 1.2e-163 NP_001303247 (OMIM: 179050) pyruvate kinase PKM is ( 566) 2484 575.7 1.4e-163 NP_872270 (OMIM: 179050) pyruvate kinase PKM isofo ( 531) 2480 574.7 2.5e-163 NP_872271 (OMIM: 179050) pyruvate kinase PKM isofo ( 531) 2480 574.7 2.5e-163 XP_016877802 (OMIM: 179050) PREDICTED: pyruvate ki ( 531) 2480 574.7 2.5e-163 XP_016856982 (OMIM: 102900,266200,609712) PREDICTE ( 383) 2396 555.5 1.1e-157 NP_001193727 (OMIM: 179050) pyruvate kinase PKM is ( 516) 2151 499.7 9.3e-141 NP_001193726 (OMIM: 179050) pyruvate kinase PKM is ( 457) 1946 453.0 9.8e-127 >>NP_000289 (OMIM: 102900,266200,609712) pyruvate kinase (574 aa) initn: 3703 init1: 3703 opt: 3703 Z-score: 4559.4 bits: 853.6 E(85289): 0 Smith-Waterman score: 3703; 100.0% identity (100.0% similar) in 574 aa overlap (1-574:1-574) 10 20 30 40 50 60 pF1KE1 MSIQENISSLQLRSWVSKSQRDLAKSILIGAPGGPAGYLRRASVAQLTQELGTAFFQQQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 MSIQENISSLQLRSWVSKSQRDLAKSILIGAPGGPAGYLRRASVAQLTQELGTAFFQQQQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 LPAAMADTFLEHLCLLDIDSEPVAARSTSIIATIGPASRSVERLKEMIKAGMNIARLNFS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 LPAAMADTFLEHLCLLDIDSEPVAARSTSIIATIGPASRSVERLKEMIKAGMNIARLNFS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 HGSHEYHAESIANVREAVESFAGSPLSYRPVAIALDTKGPEIRTGILQGGPESEVELVKG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 HGSHEYHAESIANVREAVESFAGSPLSYRPVAIALDTKGPEIRTGILQGGPESEVELVKG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 SQVLVTVDPAFRTRGNANTVWVDYPNIVRVVPVGGRIYIDDGLISLVVQKIGPEGLVTQV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 SQVLVTVDPAFRTRGNANTVWVDYPNIVRVVPVGGRIYIDDGLISLVVQKIGPEGLVTQV 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE1 ENGGVLGSRKGVNLPGAQVDLPGLSEQDVRDLRFGVEHGVDIVFASFVRKASDVAAVRAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 ENGGVLGSRKGVNLPGAQVDLPGLSEQDVRDLRFGVEHGVDIVFASFVRKASDVAAVRAA 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE1 LGPEGHGIKIISKIENHEGVKRFDEILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 LGPEGHGIKIISKIENHEGVKRFDEILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRC 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE1 NLAGKPVVCATQMLESMITKPRPTRAETSDVANAVLDGADCIMLSGETAKGNFPVEAVKM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 NLAGKPVVCATQMLESMITKPRPTRAETSDVANAVLDGADCIMLSGETAKGNFPVEAVKM 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE1 QHAIAREAEAAVYHRQLFEELRRAAPLSRDPTEVTAIGAVEAAFKCCAAAIIVLTTTGRS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 QHAIAREAEAAVYHRQLFEELRRAAPLSRDPTEVTAIGAVEAAFKCCAAAIIVLTTTGRS 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE1 AQLLSRYRPRAAVIAVTRSAQAARQVHLCRGVFPLLYREPPEAIWADDVDRRVQFGIESG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 AQLLSRYRPRAAVIAVTRSAQAARQVHLCRGVFPLLYREPPEAIWADDVDRRVQFGIESG 490 500 510 520 530 540 550 560 570 pF1KE1 KLRGFLRVGDLVIVVTGWRPGSGYTNIMRVLSIS :::::::::::::::::::::::::::::::::: NP_000 KLRGFLRVGDLVIVVTGWRPGSGYTNIMRVLSIS 550 560 570 >>NP_870986 (OMIM: 102900,266200,609712) pyruvate kinase (543 aa) initn: 3497 init1: 3497 opt: 3497 Z-score: 4306.0 bits: 806.6 E(85289): 0 Smith-Waterman score: 3497; 100.0% identity (100.0% similar) in 541 aa overlap (34-574:3-543) 10 20 30 40 50 60 pF1KE1 QENISSLQLRSWVSKSQRDLAKSILIGAPGGPAGYLRRASVAQLTQELGTAFFQQQQLPA :::::::::::::::::::::::::::::: NP_870 MEGPAGYLRRASVAQLTQELGTAFFQQQQLPA 10 20 30 70 80 90 100 110 120 pF1KE1 AMADTFLEHLCLLDIDSEPVAARSTSIIATIGPASRSVERLKEMIKAGMNIARLNFSHGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_870 AMADTFLEHLCLLDIDSEPVAARSTSIIATIGPASRSVERLKEMIKAGMNIARLNFSHGS 40 50 60 70 80 90 130 140 150 160 170 180 pF1KE1 HEYHAESIANVREAVESFAGSPLSYRPVAIALDTKGPEIRTGILQGGPESEVELVKGSQV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_870 HEYHAESIANVREAVESFAGSPLSYRPVAIALDTKGPEIRTGILQGGPESEVELVKGSQV 100 110 120 130 140 150 190 200 210 220 230 240 pF1KE1 LVTVDPAFRTRGNANTVWVDYPNIVRVVPVGGRIYIDDGLISLVVQKIGPEGLVTQVENG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_870 LVTVDPAFRTRGNANTVWVDYPNIVRVVPVGGRIYIDDGLISLVVQKIGPEGLVTQVENG 160 170 180 190 200 210 250 260 270 280 290 300 pF1KE1 GVLGSRKGVNLPGAQVDLPGLSEQDVRDLRFGVEHGVDIVFASFVRKASDVAAVRAALGP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_870 GVLGSRKGVNLPGAQVDLPGLSEQDVRDLRFGVEHGVDIVFASFVRKASDVAAVRAALGP 220 230 240 250 260 270 310 320 330 340 350 360 pF1KE1 EGHGIKIISKIENHEGVKRFDEILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_870 EGHGIKIISKIENHEGVKRFDEILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLA 280 290 300 310 320 330 370 380 390 400 410 420 pF1KE1 GKPVVCATQMLESMITKPRPTRAETSDVANAVLDGADCIMLSGETAKGNFPVEAVKMQHA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_870 GKPVVCATQMLESMITKPRPTRAETSDVANAVLDGADCIMLSGETAKGNFPVEAVKMQHA 340 350 360 370 380 390 430 440 450 460 470 480 pF1KE1 IAREAEAAVYHRQLFEELRRAAPLSRDPTEVTAIGAVEAAFKCCAAAIIVLTTTGRSAQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_870 IAREAEAAVYHRQLFEELRRAAPLSRDPTEVTAIGAVEAAFKCCAAAIIVLTTTGRSAQL 400 410 420 430 440 450 490 500 510 520 530 540 pF1KE1 LSRYRPRAAVIAVTRSAQAARQVHLCRGVFPLLYREPPEAIWADDVDRRVQFGIESGKLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_870 LSRYRPRAAVIAVTRSAQAARQVHLCRGVFPLLYREPPEAIWADDVDRRVQFGIESGKLR 460 470 480 490 500 510 550 560 570 pF1KE1 GFLRVGDLVIVVTGWRPGSGYTNIMRVLSIS ::::::::::::::::::::::::::::::: NP_870 GFLRVGDLVIVVTGWRPGSGYTNIMRVLSIS 520 530 540 >>XP_011507942 (OMIM: 102900,266200,609712) PREDICTED: p (510 aa) initn: 3297 init1: 3297 opt: 3297 Z-score: 4060.0 bits: 761.0 E(85289): 0 Smith-Waterman score: 3297; 100.0% identity (100.0% similar) in 510 aa overlap (65-574:1-510) 40 50 60 70 80 90 pF1KE1 PAGYLRRASVAQLTQELGTAFFQQQQLPAAMADTFLEHLCLLDIDSEPVAARSTSIIATI :::::::::::::::::::::::::::::: XP_011 MADTFLEHLCLLDIDSEPVAARSTSIIATI 10 20 30 100 110 120 130 140 150 pF1KE1 GPASRSVERLKEMIKAGMNIARLNFSHGSHEYHAESIANVREAVESFAGSPLSYRPVAIA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GPASRSVERLKEMIKAGMNIARLNFSHGSHEYHAESIANVREAVESFAGSPLSYRPVAIA 40 50 60 70 80 90 160 170 180 190 200 210 pF1KE1 LDTKGPEIRTGILQGGPESEVELVKGSQVLVTVDPAFRTRGNANTVWVDYPNIVRVVPVG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LDTKGPEIRTGILQGGPESEVELVKGSQVLVTVDPAFRTRGNANTVWVDYPNIVRVVPVG 100 110 120 130 140 150 220 230 240 250 260 270 pF1KE1 GRIYIDDGLISLVVQKIGPEGLVTQVENGGVLGSRKGVNLPGAQVDLPGLSEQDVRDLRF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GRIYIDDGLISLVVQKIGPEGLVTQVENGGVLGSRKGVNLPGAQVDLPGLSEQDVRDLRF 160 170 180 190 200 210 280 290 300 310 320 330 pF1KE1 GVEHGVDIVFASFVRKASDVAAVRAALGPEGHGIKIISKIENHEGVKRFDEILEVSDGIM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GVEHGVDIVFASFVRKASDVAAVRAALGPEGHGIKIISKIENHEGVKRFDEILEVSDGIM 220 230 240 250 260 270 340 350 360 370 380 390 pF1KE1 VARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKPRPTRAETSDVANA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKPRPTRAETSDVANA 280 290 300 310 320 330 400 410 420 430 440 450 pF1KE1 VLDGADCIMLSGETAKGNFPVEAVKMQHAIAREAEAAVYHRQLFEELRRAAPLSRDPTEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VLDGADCIMLSGETAKGNFPVEAVKMQHAIAREAEAAVYHRQLFEELRRAAPLSRDPTEV 340 350 360 370 380 390 460 470 480 490 500 510 pF1KE1 TAIGAVEAAFKCCAAAIIVLTTTGRSAQLLSRYRPRAAVIAVTRSAQAARQVHLCRGVFP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TAIGAVEAAFKCCAAAIIVLTTTGRSAQLLSRYRPRAAVIAVTRSAQAARQVHLCRGVFP 400 410 420 430 440 450 520 530 540 550 560 570 pF1KE1 LLYREPPEAIWADDVDRRVQFGIESGKLRGFLRVGDLVIVVTGWRPGSGYTNIMRVLSIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LLYREPPEAIWADDVDRRVQFGIESGKLRGFLRVGDLVIVVTGWRPGSGYTNIMRVLSIS 460 470 480 490 500 510 >>XP_006711449 (OMIM: 102900,266200,609712) PREDICTED: p (510 aa) initn: 3297 init1: 3297 opt: 3297 Z-score: 4060.0 bits: 761.0 E(85289): 0 Smith-Waterman score: 3297; 100.0% identity (100.0% similar) in 510 aa overlap (65-574:1-510) 40 50 60 70 80 90 pF1KE1 PAGYLRRASVAQLTQELGTAFFQQQQLPAAMADTFLEHLCLLDIDSEPVAARSTSIIATI :::::::::::::::::::::::::::::: XP_006 MADTFLEHLCLLDIDSEPVAARSTSIIATI 10 20 30 100 110 120 130 140 150 pF1KE1 GPASRSVERLKEMIKAGMNIARLNFSHGSHEYHAESIANVREAVESFAGSPLSYRPVAIA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 GPASRSVERLKEMIKAGMNIARLNFSHGSHEYHAESIANVREAVESFAGSPLSYRPVAIA 40 50 60 70 80 90 160 170 180 190 200 210 pF1KE1 LDTKGPEIRTGILQGGPESEVELVKGSQVLVTVDPAFRTRGNANTVWVDYPNIVRVVPVG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LDTKGPEIRTGILQGGPESEVELVKGSQVLVTVDPAFRTRGNANTVWVDYPNIVRVVPVG 100 110 120 130 140 150 220 230 240 250 260 270 pF1KE1 GRIYIDDGLISLVVQKIGPEGLVTQVENGGVLGSRKGVNLPGAQVDLPGLSEQDVRDLRF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 GRIYIDDGLISLVVQKIGPEGLVTQVENGGVLGSRKGVNLPGAQVDLPGLSEQDVRDLRF 160 170 180 190 200 210 280 290 300 310 320 330 pF1KE1 GVEHGVDIVFASFVRKASDVAAVRAALGPEGHGIKIISKIENHEGVKRFDEILEVSDGIM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 GVEHGVDIVFASFVRKASDVAAVRAALGPEGHGIKIISKIENHEGVKRFDEILEVSDGIM 220 230 240 250 260 270 340 350 360 370 380 390 pF1KE1 VARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKPRPTRAETSDVANA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 VARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKPRPTRAETSDVANA 280 290 300 310 320 330 400 410 420 430 440 450 pF1KE1 VLDGADCIMLSGETAKGNFPVEAVKMQHAIAREAEAAVYHRQLFEELRRAAPLSRDPTEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 VLDGADCIMLSGETAKGNFPVEAVKMQHAIAREAEAAVYHRQLFEELRRAAPLSRDPTEV 340 350 360 370 380 390 460 470 480 490 500 510 pF1KE1 TAIGAVEAAFKCCAAAIIVLTTTGRSAQLLSRYRPRAAVIAVTRSAQAARQVHLCRGVFP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 TAIGAVEAAFKCCAAAIIVLTTTGRSAQLLSRYRPRAAVIAVTRSAQAARQVHLCRGVFP 400 410 420 430 440 450 520 530 540 550 560 570 pF1KE1 LLYREPPEAIWADDVDRRVQFGIESGKLRGFLRVGDLVIVVTGWRPGSGYTNIMRVLSIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LLYREPPEAIWADDVDRRVQFGIESGKLRGFLRVGDLVIVVTGWRPGSGYTNIMRVLSIS 460 470 480 490 500 510 >>XP_005254500 (OMIM: 179050) PREDICTED: pyruvate kinase (591 aa) initn: 2575 init1: 2543 opt: 2559 Z-score: 3149.8 bits: 592.8 E(85289): 1.1e-168 Smith-Waterman score: 2559; 69.9% identity (87.9% similar) in 544 aa overlap (30-573:48-590) 10 20 30 40 50 pF1KE1 MSIQENISSLQLRSWVSKSQRDLAKSILIGAPGGPAGYLRRASVAQLTQELGTAFFQQQ :.: : . :.... .: ::::.: : XP_005 SPGHTVFSSERSLLVRPRSHPEPKGEHYVTGSPT-PENQRTSAAMSKPHSEAGTAFIQTQ 20 30 40 50 60 70 60 70 80 90 100 110 pF1KE1 QLPAAMADTFLEHLCLLDIDSEPVAARSTSIIATIGPASRSVERLKEMIKAGMNIARLNF :: ::::::::::.: ::::: :..::.:.:: :::::::::: ::::::.:::.::::: XP_005 QLHAAMADTFLEHMCRLDIDSPPITARNTGIICTIGPASRSVETLKEMIKSGMNVARLNF 80 90 100 110 120 130 120 130 140 150 160 170 pF1KE1 SHGSHEYHAESIANVREAVESFAGSPLSYRPVAIALDTKGPEIRTGILQGGPESEVELVK :::.::::::.: ::: :.::::..:. :::::.::::::::::::...:. .:::: : XP_005 SHGTHEYHAETIKNVRTATESFASDPILYRPVAVALDTKGPEIRTGLIKGSGTAEVELKK 140 150 160 170 180 190 180 190 200 210 220 230 pF1KE1 GSQVLVTVDPAFRTRGNANTVWVDYPNIVRVVPVGGRIYIDDGLISLVVQKIGPEGLVTQ :. . .:.: :. . . : .:.:: :: .:: ::..::.::::::: :.. : . :::. XP_005 GATLKITLDNAYMEKCDENILWLDYKNICKVVEVGSKIYVDDGLISLQVKQKGADFLVTE 200 210 220 230 240 250 240 250 260 270 280 290 pF1KE1 VENGGVLGSRKGVNLPGAQVDLPGLSEQDVRDLRFGVEHGVDIVFASFVRKASDVAAVRA ::::: :::.:::::::: ::::..::.:..::.::::. ::.:::::.:::::: :: XP_005 VENGGSLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKASDVHEVRK 260 270 280 290 300 310 300 310 320 330 340 350 pF1KE1 ALGPEGHGIKIISKIENHEGVKRFDEILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGR .:: .:..:::::::::::::.:::::::.:::::::::::::::::::::::::::::: XP_005 VLGEKGKNIKIISKIENHEGVRRFDEILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGR 320 330 340 350 360 370 360 370 380 390 400 410 pF1KE1 CNLAGKPVVCATQMLESMITKPRPTRAETSDVANAVLDGADCIMLSGETAKGNFPVEAVK :: :::::.:::::::::: :::::::: :::::::::::::::::::::::..:.:::. XP_005 CNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPLEAVR 380 390 400 410 420 430 420 430 440 450 460 470 pF1KE1 MQHAIAREAEAAVYHRQLFEELRRAAPLSRDPTEVTAIGAVEAAFKCCAAAIIVLTTTGR ::: ::::::::.:: :::::::: ::.. ::::.::.:::::.::::..:::::: .:: XP_005 MQHLIAREAEAAIYHLQLFEELRRLAPITSDPTEATAVGAVEASFKCCSGAIIVLTKSGR 440 450 460 470 480 490 480 490 500 510 520 530 pF1KE1 SAQLLSRYRPRAAVIAVTRSAQAARQVHLCRGVFPLLYREPPEAIWADDVDRRVQFGIES ::. ..:::::: .:::::. :.:::.:: ::.::.: ..: . ::.::: ::.:... XP_005 SAHQVARYRPRAPIIAVTRNPQTARQAHLYRGIFPVLCKDPVQEAWAEDVDLRVNFAMNV 500 510 520 530 540 550 540 550 560 570 pF1KE1 GKLRGFLRVGDLVIVVTGWRPGSGYTNIMRVLSIS :: :::.. ::.:::.::::::::.:: :::. . XP_005 GKARGFFKKGDVVIVLTGWRPGSGFTNTMRVVPVP 560 570 580 590 >>XP_006720633 (OMIM: 179050) PREDICTED: pyruvate kinase (605 aa) initn: 2575 init1: 2543 opt: 2559 Z-score: 3149.6 bits: 592.8 E(85289): 1.1e-168 Smith-Waterman score: 2559; 69.9% identity (87.9% similar) in 544 aa overlap (30-573:62-604) 10 20 30 40 50 pF1KE1 MSIQENISSLQLRSWVSKSQRDLAKSILIGAPGGPAGYLRRASVAQLTQELGTAFFQQQ :.: : . :.... .: ::::.: : XP_006 SPGHTVFSSERSLLVRPRSHPEPKGEHYVTGSPT-PENQRTSAAMSKPHSEAGTAFIQTQ 40 50 60 70 80 90 60 70 80 90 100 110 pF1KE1 QLPAAMADTFLEHLCLLDIDSEPVAARSTSIIATIGPASRSVERLKEMIKAGMNIARLNF :: ::::::::::.: ::::: :..::.:.:: :::::::::: ::::::.:::.::::: XP_006 QLHAAMADTFLEHMCRLDIDSPPITARNTGIICTIGPASRSVETLKEMIKSGMNVARLNF 100 110 120 130 140 150 120 130 140 150 160 170 pF1KE1 SHGSHEYHAESIANVREAVESFAGSPLSYRPVAIALDTKGPEIRTGILQGGPESEVELVK :::.::::::.: ::: :.::::..:. :::::.::::::::::::...:. .:::: : XP_006 SHGTHEYHAETIKNVRTATESFASDPILYRPVAVALDTKGPEIRTGLIKGSGTAEVELKK 160 170 180 190 200 210 180 190 200 210 220 230 pF1KE1 GSQVLVTVDPAFRTRGNANTVWVDYPNIVRVVPVGGRIYIDDGLISLVVQKIGPEGLVTQ :. . .:.: :. . . : .:.:: :: .:: ::..::.::::::: :.. : . :::. XP_006 GATLKITLDNAYMEKCDENILWLDYKNICKVVEVGSKIYVDDGLISLQVKQKGADFLVTE 220 230 240 250 260 270 240 250 260 270 280 290 pF1KE1 VENGGVLGSRKGVNLPGAQVDLPGLSEQDVRDLRFGVEHGVDIVFASFVRKASDVAAVRA ::::: :::.:::::::: ::::..::.:..::.::::. ::.:::::.:::::: :: XP_006 VENGGSLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKASDVHEVRK 280 290 300 310 320 330 300 310 320 330 340 350 pF1KE1 ALGPEGHGIKIISKIENHEGVKRFDEILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGR .:: .:..:::::::::::::.:::::::.:::::::::::::::::::::::::::::: XP_006 VLGEKGKNIKIISKIENHEGVRRFDEILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGR 340 350 360 370 380 390 360 370 380 390 400 410 pF1KE1 CNLAGKPVVCATQMLESMITKPRPTRAETSDVANAVLDGADCIMLSGETAKGNFPVEAVK :: :::::.:::::::::: :::::::: :::::::::::::::::::::::..:.:::. XP_006 CNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPLEAVR 400 410 420 430 440 450 420 430 440 450 460 470 pF1KE1 MQHAIAREAEAAVYHRQLFEELRRAAPLSRDPTEVTAIGAVEAAFKCCAAAIIVLTTTGR ::: ::::::::.:: :::::::: ::.. ::::.::.:::::.::::..:::::: .:: XP_006 MQHLIAREAEAAIYHLQLFEELRRLAPITSDPTEATAVGAVEASFKCCSGAIIVLTKSGR 460 470 480 490 500 510 480 490 500 510 520 530 pF1KE1 SAQLLSRYRPRAAVIAVTRSAQAARQVHLCRGVFPLLYREPPEAIWADDVDRRVQFGIES ::. ..:::::: .:::::. :.:::.:: ::.::.: ..: . ::.::: ::.:... XP_006 SAHQVARYRPRAPIIAVTRNPQTARQAHLYRGIFPVLCKDPVQEAWAEDVDLRVNFAMNV 520 530 540 550 560 570 540 550 560 570 pF1KE1 GKLRGFLRVGDLVIVVTGWRPGSGYTNIMRVLSIS :: :::.. ::.:::.::::::::.:: :::. . XP_006 GKARGFFKKGDVVIVLTGWRPGSGFTNTMRVVPVP 580 590 600 >>XP_011519972 (OMIM: 179050) PREDICTED: pyruvate kinase (566 aa) initn: 2575 init1: 2543 opt: 2551 Z-score: 3140.2 bits: 590.9 E(85289): 3.6e-168 Smith-Waterman score: 2551; 70.9% identity (88.9% similar) in 532 aa overlap (42-573:34-565) 20 30 40 50 60 70 pF1KE1 LRSWVSKSQRDLAKSILIGAPGGPAGYLRRASVAQLTQELGTAFFQQQQLPAAMADTFLE :.... .: ::::.: ::: ::::::::: XP_011 SSERGERLLTPGACSSEVPSAVPSRSGGTSAAMSKPHSEAGTAFIQTQQLHAAMADTFLE 10 20 30 40 50 60 80 90 100 110 120 130 pF1KE1 HLCLLDIDSEPVAARSTSIIATIGPASRSVERLKEMIKAGMNIARLNFSHGSHEYHAESI :.: ::::: :..::.:.:: :::::::::: ::::::.:::.::::::::.::::::.: XP_011 HMCRLDIDSPPITARNTGIICTIGPASRSVETLKEMIKSGMNVARLNFSHGTHEYHAETI 70 80 90 100 110 120 140 150 160 170 180 190 pF1KE1 ANVREAVESFAGSPLSYRPVAIALDTKGPEIRTGILQGGPESEVELVKGSQVLVTVDPAF ::: :.::::..:. :::::.::::::::::::...:. .:::: ::. . .:.: :. XP_011 KNVRTATESFASDPILYRPVAVALDTKGPEIRTGLIKGSGTAEVELKKGATLKITLDNAY 130 140 150 160 170 180 200 210 220 230 240 250 pF1KE1 RTRGNANTVWVDYPNIVRVVPVGGRIYIDDGLISLVVQKIGPEGLVTQVENGGVLGSRKG . . : .:.:: :: .:: ::..::.::::::: :.. : . :::.::::: :::.:: XP_011 MEKCDENILWLDYKNICKVVEVGSKIYVDDGLISLQVKQKGADFLVTEVENGGSLGSKKG 190 200 210 220 230 240 260 270 280 290 300 310 pF1KE1 VNLPGAQVDLPGLSEQDVRDLRFGVEHGVDIVFASFVRKASDVAAVRAALGPEGHGIKII :::::: ::::..::.:..::.::::. ::.:::::.:::::: :: .:: .:..:::: XP_011 VNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKASDVHEVRKVLGEKGKNIKII 250 260 270 280 290 300 320 330 340 350 360 370 pF1KE1 SKIENHEGVKRFDEILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCAT :::::::::.:::::::.:::::::::::::::::::::::::::::::: :::::.::: XP_011 SKIENHEGVRRFDEILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICAT 310 320 330 340 350 360 380 390 400 410 420 430 pF1KE1 QMLESMITKPRPTRAETSDVANAVLDGADCIMLSGETAKGNFPVEAVKMQHAIAREAEAA ::::::: :::::::: :::::::::::::::::::::::..:.:::.::: :::::::: XP_011 QMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHLIAREAEAA 370 380 390 400 410 420 440 450 460 470 480 490 pF1KE1 VYHRQLFEELRRAAPLSRDPTEVTAIGAVEAAFKCCAAAIIVLTTTGRSAQLLSRYRPRA .:: :::::::: ::.. ::::.::.:::::.::::..:::::: .::::. ..:::::: XP_011 IYHLQLFEELRRLAPITSDPTEATAVGAVEASFKCCSGAIIVLTKSGRSAHQVARYRPRA 430 440 450 460 470 480 500 510 520 530 540 550 pF1KE1 AVIAVTRSAQAARQVHLCRGVFPLLYREPPEAIWADDVDRRVQFGIESGKLRGFLRVGDL .:::::. :.:::.:: ::.::.: ..: . ::.::: ::.:... :: :::.. ::. XP_011 PIIAVTRNPQTARQAHLYRGIFPVLCKDPVQEAWAEDVDLRVNFAMNVGKARGFFKKGDV 490 500 510 520 530 540 560 570 pF1KE1 VIVVTGWRPGSGYTNIMRVLSIS :::.::::::::.:: :::. . XP_011 VIVLTGWRPGSGFTNTMRVVPVP 550 560 >>XP_005254502 (OMIM: 179050) PREDICTED: pyruvate kinase (531 aa) initn: 2575 init1: 2543 opt: 2547 Z-score: 3135.7 bits: 590.0 E(85289): 6.4e-168 Smith-Waterman score: 2547; 71.8% identity (89.1% similar) in 524 aa overlap (50-573:7-530) 20 30 40 50 60 70 pF1KE1 QRDLAKSILIGAPGGPAGYLRRASVAQLTQELGTAFFQQQQLPAAMADTFLEHLCLLDID : ::::.: ::: ::::::::::.: :::: XP_005 MSKPHSEAGTAFIQTQQLHAAMADTFLEHMCRLDID 10 20 30 80 90 100 110 120 130 pF1KE1 SEPVAARSTSIIATIGPASRSVERLKEMIKAGMNIARLNFSHGSHEYHAESIANVREAVE : :..::.:.:: :::::::::: ::::::.:::.::::::::.::::::.: ::: :.: XP_005 SPPITARNTGIICTIGPASRSVETLKEMIKSGMNVARLNFSHGTHEYHAETIKNVRTATE 40 50 60 70 80 90 140 150 160 170 180 190 pF1KE1 SFAGSPLSYRPVAIALDTKGPEIRTGILQGGPESEVELVKGSQVLVTVDPAFRTRGNANT :::..:. :::::.::::::::::::...:. .:::: ::. . .:.: :. . . : XP_005 SFASDPILYRPVAVALDTKGPEIRTGLIKGSGTAEVELKKGATLKITLDNAYMEKCDENI 100 110 120 130 140 150 200 210 220 230 240 250 pF1KE1 VWVDYPNIVRVVPVGGRIYIDDGLISLVVQKIGPEGLVTQVENGGVLGSRKGVNLPGAQV .:.:: :: .:: ::..::.::::::: :.. : . :::.::::: :::.:::::::: : XP_005 LWLDYKNICKVVEVGSKIYVDDGLISLQVKQKGADFLVTEVENGGSLGSKKGVNLPGAAV 160 170 180 190 200 210 260 270 280 290 300 310 pF1KE1 DLPGLSEQDVRDLRFGVEHGVDIVFASFVRKASDVAAVRAALGPEGHGIKIISKIENHEG :::..::.:..::.::::. ::.:::::.:::::: :: .:: .:..:::::::::::: XP_005 DLPAVSEKDIQDLKFGVEQDVDMVFASFIRKASDVHEVRKVLGEKGKNIKIISKIENHEG 220 230 240 250 260 270 320 330 340 350 360 370 pF1KE1 VKRFDEILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMIT :.:::::::.:::::::::::::::::::::::::::::::: :::::.:::::::::: XP_005 VRRFDEILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIK 280 290 300 310 320 330 380 390 400 410 420 430 pF1KE1 KPRPTRAETSDVANAVLDGADCIMLSGETAKGNFPVEAVKMQHAIAREAEAAVYHRQLFE :::::::: :::::::::::::::::::::::..:.:::.::: ::::::::.:: :::: XP_005 KPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHLIAREAEAAIYHLQLFE 340 350 360 370 380 390 440 450 460 470 480 490 pF1KE1 ELRRAAPLSRDPTEVTAIGAVEAAFKCCAAAIIVLTTTGRSAQLLSRYRPRAAVIAVTRS :::: ::.. ::::.::.:::::.::::..:::::: .::::. ..:::::: .:::::. XP_005 ELRRLAPITSDPTEATAVGAVEASFKCCSGAIIVLTKSGRSAHQVARYRPRAPIIAVTRN 400 410 420 430 440 450 500 510 520 530 540 550 pF1KE1 AQAARQVHLCRGVFPLLYREPPEAIWADDVDRRVQFGIESGKLRGFLRVGDLVIVVTGWR :.:::.:: ::.::.: ..: . ::.::: ::.:... :: :::.. ::.:::.:::: XP_005 PQTARQAHLYRGIFPVLCKDPVQEAWAEDVDLRVNFAMNVGKARGFFKKGDVVIVLTGWR 460 470 480 490 500 510 560 570 pF1KE1 PGSGYTNIMRVLSIS ::::.:: :::. . XP_005 PGSGFTNTMRVVPVP 520 530 >>NP_002645 (OMIM: 179050) pyruvate kinase PKM isoform a (531 aa) initn: 2575 init1: 2543 opt: 2547 Z-score: 3135.7 bits: 590.0 E(85289): 6.4e-168 Smith-Waterman score: 2547; 71.8% identity (89.1% similar) in 524 aa overlap (50-573:7-530) 20 30 40 50 60 70 pF1KE1 QRDLAKSILIGAPGGPAGYLRRASVAQLTQELGTAFFQQQQLPAAMADTFLEHLCLLDID : ::::.: ::: ::::::::::.: :::: NP_002 MSKPHSEAGTAFIQTQQLHAAMADTFLEHMCRLDID 10 20 30 80 90 100 110 120 130 pF1KE1 SEPVAARSTSIIATIGPASRSVERLKEMIKAGMNIARLNFSHGSHEYHAESIANVREAVE : :..::.:.:: :::::::::: ::::::.:::.::::::::.::::::.: ::: :.: NP_002 SPPITARNTGIICTIGPASRSVETLKEMIKSGMNVARLNFSHGTHEYHAETIKNVRTATE 40 50 60 70 80 90 140 150 160 170 180 190 pF1KE1 SFAGSPLSYRPVAIALDTKGPEIRTGILQGGPESEVELVKGSQVLVTVDPAFRTRGNANT :::..:. :::::.::::::::::::...:. .:::: ::. . .:.: :. . . : NP_002 SFASDPILYRPVAVALDTKGPEIRTGLIKGSGTAEVELKKGATLKITLDNAYMEKCDENI 100 110 120 130 140 150 200 210 220 230 240 250 pF1KE1 VWVDYPNIVRVVPVGGRIYIDDGLISLVVQKIGPEGLVTQVENGGVLGSRKGVNLPGAQV .:.:: :: .:: ::..::.::::::: :.. : . :::.::::: :::.:::::::: : NP_002 LWLDYKNICKVVEVGSKIYVDDGLISLQVKQKGADFLVTEVENGGSLGSKKGVNLPGAAV 160 170 180 190 200 210 260 270 280 290 300 310 pF1KE1 DLPGLSEQDVRDLRFGVEHGVDIVFASFVRKASDVAAVRAALGPEGHGIKIISKIENHEG :::..::.:..::.::::. ::.:::::.:::::: :: .:: .:..:::::::::::: NP_002 DLPAVSEKDIQDLKFGVEQDVDMVFASFIRKASDVHEVRKVLGEKGKNIKIISKIENHEG 220 230 240 250 260 270 320 330 340 350 360 370 pF1KE1 VKRFDEILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMIT :.:::::::.:::::::::::::::::::::::::::::::: :::::.:::::::::: NP_002 VRRFDEILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIK 280 290 300 310 320 330 380 390 400 410 420 430 pF1KE1 KPRPTRAETSDVANAVLDGADCIMLSGETAKGNFPVEAVKMQHAIAREAEAAVYHRQLFE :::::::: :::::::::::::::::::::::..:.:::.::: ::::::::.:: :::: NP_002 KPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHLIAREAEAAIYHLQLFE 340 350 360 370 380 390 440 450 460 470 480 490 pF1KE1 ELRRAAPLSRDPTEVTAIGAVEAAFKCCAAAIIVLTTTGRSAQLLSRYRPRAAVIAVTRS :::: ::.. ::::.::.:::::.::::..:::::: .::::. ..:::::: .:::::. NP_002 ELRRLAPITSDPTEATAVGAVEASFKCCSGAIIVLTKSGRSAHQVARYRPRAPIIAVTRN 400 410 420 430 440 450 500 510 520 530 540 550 pF1KE1 AQAARQVHLCRGVFPLLYREPPEAIWADDVDRRVQFGIESGKLRGFLRVGDLVIVVTGWR :.:::.:: ::.::.: ..: . ::.::: ::.:... :: :::.. ::.:::.:::: NP_002 PQTARQAHLYRGIFPVLCKDPVQEAWAEDVDLRVNFAMNVGKARGFFKKGDVVIVLTGWR 460 470 480 490 500 510 560 570 pF1KE1 PGSGYTNIMRVLSIS ::::.:: :::. . NP_002 PGSGFTNTMRVVPVP 520 530 >>NP_001193725 (OMIM: 179050) pyruvate kinase PKM isofor (605 aa) initn: 2508 init1: 2476 opt: 2492 Z-score: 3067.1 bits: 577.5 E(85289): 4.3e-164 Smith-Waterman score: 2492; 68.6% identity (86.9% similar) in 544 aa overlap (30-573:62-604) 10 20 30 40 50 pF1KE1 MSIQENISSLQLRSWVSKSQRDLAKSILIGAPGGPAGYLRRASVAQLTQELGTAFFQQQ :.: : . :.... .: ::::.: : NP_001 SPGHTVFSSERSLLVRPRSHPEPKGEHYVTGSPT-PENQRTSAAMSKPHSEAGTAFIQTQ 40 50 60 70 80 90 60 70 80 90 100 110 pF1KE1 QLPAAMADTFLEHLCLLDIDSEPVAARSTSIIATIGPASRSVERLKEMIKAGMNIARLNF :: ::::::::::.: ::::: :..::.:.:: :::::::::: ::::::.:::.::::: NP_001 QLHAAMADTFLEHMCRLDIDSPPITARNTGIICTIGPASRSVETLKEMIKSGMNVARLNF 100 110 120 130 140 150 120 130 140 150 160 170 pF1KE1 SHGSHEYHAESIANVREAVESFAGSPLSYRPVAIALDTKGPEIRTGILQGGPESEVELVK :::.::::::.: ::: :.::::..:. :::::.::::::::::::...:. .:::: : NP_001 SHGTHEYHAETIKNVRTATESFASDPILYRPVAVALDTKGPEIRTGLIKGSGTAEVELKK 160 170 180 190 200 210 180 190 200 210 220 230 pF1KE1 GSQVLVTVDPAFRTRGNANTVWVDYPNIVRVVPVGGRIYIDDGLISLVVQKIGPEGLVTQ :. . .:.: :. . . : .:.:: :: .:: ::..::.::::::: :.. : . :::. NP_001 GATLKITLDNAYMEKCDENILWLDYKNICKVVEVGSKIYVDDGLISLQVKQKGADFLVTE 220 230 240 250 260 270 240 250 260 270 280 290 pF1KE1 VENGGVLGSRKGVNLPGAQVDLPGLSEQDVRDLRFGVEHGVDIVFASFVRKASDVAAVRA ::::: :::.:::::::: ::::..::.:..::.::::. ::.:::::.:::::: :: NP_001 VENGGSLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKASDVHEVRK 280 290 300 310 320 330 300 310 320 330 340 350 pF1KE1 ALGPEGHGIKIISKIENHEGVKRFDEILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGR .:: .:..:::::::::::::.:::::::.:::::::::::::::::::::::::::::: NP_001 VLGEKGKNIKIISKIENHEGVRRFDEILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGR 340 350 360 370 380 390 360 370 380 390 400 410 pF1KE1 CNLAGKPVVCATQMLESMITKPRPTRAETSDVANAVLDGADCIMLSGETAKGNFPVEAVK :: :::::.:::::::::: :::::::: :::::::::::::::::::::::..:.:::. NP_001 CNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPLEAVR 400 410 420 430 440 450 420 430 440 450 460 470 pF1KE1 MQHAIAREAEAAVYHRQLFEELRRAAPLSRDPTEVTAIGAVEAAFKCCAAAIIVLTTTGR ::: ::::::::..::.::::: ::. : : :. :.:.:::..:: :::.:::: .:: NP_001 MQHLIAREAEAAMFHRKLFEELVRASSHSTDLMEAMAMGSVEASYKCLAAALIVLTESGR 460 470 480 490 500 510 480 490 500 510 520 530 pF1KE1 SAQLLSRYRPRAAVIAVTRSAQAARQVHLCRGVFPLLYREPPEAIWADDVDRRVQFGIES ::. ..:::::: .:::::. :.:::.:: ::.::.: ..: . ::.::: ::.:... NP_001 SAHQVARYRPRAPIIAVTRNPQTARQAHLYRGIFPVLCKDPVQEAWAEDVDLRVNFAMNV 520 530 540 550 560 570 540 550 560 570 pF1KE1 GKLRGFLRVGDLVIVVTGWRPGSGYTNIMRVLSIS :: :::.. ::.:::.::::::::.:: :::. . NP_001 GKARGFFKKGDVVIVLTGWRPGSGFTNTMRVVPVP 580 590 600 574 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 22:36:38 2016 done: Sun Nov 6 22:36:40 2016 Total Scan time: 9.080 Total Display time: 0.110 Function used was FASTA [36.3.4 Apr, 2011]