FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE3601, 179 aa 1>>>pF1KE3601 179 - 179 aa - 179 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.0030+/-0.00031; mu= 14.9098+/- 0.019 mean_var=62.6818+/-12.429, 0's: 0 Z-trim(116.8): 128 B-trim: 322 in 1/51 Lambda= 0.161996 statistics sampled from 28108 (28242) to 28108 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.724), E-opt: 0.2 (0.331), width: 16 Scan time: 5.850 The best scores are: opt bits E(85289) NP_008950 (OMIM: 605574) ubiquitin-conjugating enz ( 179) 1197 287.6 7.3e-78 NP_861517 (OMIM: 605574) ubiquitin-conjugating enz ( 140) 947 229.1 2.3e-60 NP_861516 (OMIM: 605574) ubiquitin-conjugating enz ( 150) 724 177.0 1.2e-44 NP_861515 (OMIM: 605574) ubiquitin-conjugating enz ( 161) 483 120.7 1.1e-27 NP_001268671 (OMIM: 605574) ubiquitin-conjugating ( 79) 473 118.2 3.2e-27 NP_003328 (OMIM: 179095) ubiquitin-conjugating enz ( 152) 411 103.9 1.3e-22 NP_003327 (OMIM: 300860,312180) ubiquitin-conjugat ( 152) 408 103.2 2.1e-22 NP_003339 (OMIM: 603679) ubiquitin-conjugating enz ( 152) 366 93.3 1.9e-19 NP_003329 (OMIM: 602961) ubiquitin-conjugating enz ( 147) 362 92.4 3.4e-19 NP_001269090 (OMIM: 300860,312180) ubiquitin-conju ( 119) 356 90.9 7.7e-19 NP_003330 (OMIM: 602962) ubiquitin-conjugating enz ( 147) 347 88.9 3.9e-18 NP_871617 (OMIM: 602963) ubiquitin-conjugating enz ( 147) 345 88.4 5.4e-18 NP_871615 (OMIM: 602963) ubiquitin-conjugating enz ( 147) 345 88.4 5.4e-18 NP_003331 (OMIM: 602963) ubiquitin-conjugating enz ( 147) 345 88.4 5.4e-18 NP_871620 (OMIM: 602963) ubiquitin-conjugating enz ( 147) 345 88.4 5.4e-18 NP_871619 (OMIM: 602963) ubiquitin-conjugating enz ( 147) 345 88.4 5.4e-18 NP_871618 (OMIM: 602963) ubiquitin-conjugating enz ( 147) 345 88.4 5.4e-18 NP_871616 (OMIM: 602963) ubiquitin-conjugating enz ( 147) 345 88.4 5.4e-18 NP_871621 (OMIM: 602963) ubiquitin-conjugating enz ( 148) 345 88.4 5.4e-18 NP_872619 (OMIM: 604151) ubiquitin-conjugating enz ( 207) 340 87.3 1.6e-17 NP_006348 (OMIM: 604151) ubiquitin-conjugating enz ( 207) 340 87.3 1.6e-17 XP_005246301 (OMIM: 604151) PREDICTED: ubiquitin-c ( 207) 340 87.3 1.6e-17 NP_001265484 (OMIM: 604151) ubiquitin-conjugating ( 207) 340 87.3 1.6e-17 NP_001265483 (OMIM: 604151) ubiquitin-conjugating ( 207) 340 87.3 1.6e-17 NP_871622 (OMIM: 602963) ubiquitin-conjugating enz ( 149) 337 86.6 2e-17 NP_689866 (OMIM: 602163) ubiquitin-conjugating enz ( 201) 338 86.9 2.2e-17 XP_005265489 (OMIM: 602163) PREDICTED: ubiquitin-c ( 201) 338 86.9 2.2e-17 XP_016865309 (OMIM: 602962) PREDICTED: ubiquitin-c ( 173) 335 86.1 3.1e-17 NP_001189405 (OMIM: 602916) ubiquitin-conjugating ( 160) 330 84.9 6.6e-17 NP_003332 (OMIM: 602916) ubiquitin-conjugating enz ( 193) 325 83.8 1.7e-16 XP_005265488 (OMIM: 602916) PREDICTED: ubiquitin-c ( 167) 323 83.3 2.1e-16 XP_005265490 (OMIM: 602163) PREDICTED: ubiquitin-c ( 189) 323 83.3 2.3e-16 NP_054895 (OMIM: 610538,616435) ubiquitin-conjugat ( 197) 323 83.4 2.4e-16 NP_005330 (OMIM: 602846) ubiquitin-conjugating enz ( 200) 309 80.1 2.4e-15 NP_862821 (OMIM: 602962) ubiquitin-conjugating enz ( 118) 304 78.8 3.5e-15 NP_001287724 (OMIM: 602963) ubiquitin-conjugating ( 118) 303 78.5 4.1e-15 XP_016864073 (OMIM: 602963) PREDICTED: ubiquitin-c ( 118) 303 78.5 4.1e-15 NP_003960 (OMIM: 603173) NEDD8-conjugating enzyme ( 183) 305 79.1 4.2e-15 NP_872607 (OMIM: 602916) ubiquitin-conjugating enz ( 176) 294 76.6 2.4e-14 NP_001297255 (OMIM: 610538,616435) ubiquitin-conju ( 167) 286 74.7 8.5e-14 NP_003335 (OMIM: 601082) ubiquitin-conjugating enz ( 183) 286 74.7 9.2e-14 NP_001104582 (OMIM: 602846) ubiquitin-conjugating ( 157) 284 74.2 1.1e-13 NP_001268670 (OMIM: 605574) ubiquitin-conjugating ( 132) 279 73.0 2.2e-13 XP_016872098 (OMIM: 602961) PREDICTED: ubiquitin-c ( 110) 278 72.7 2.2e-13 NP_055316 (OMIM: 610309) ubiquitin-conjugating enz ( 222) 277 72.6 4.6e-13 NP_001257944 (OMIM: 614277) ubiquitin-conjugating ( 188) 276 72.4 4.7e-13 NP_001191809 (OMIM: 602961) ubiquitin-conjugating ( 109) 273 71.5 4.9e-13 NP_919235 (OMIM: 601661) SUMO-conjugating enzyme U ( 158) 274 71.8 5.7e-13 NP_919236 (OMIM: 601661) SUMO-conjugating enzyme U ( 158) 274 71.8 5.7e-13 NP_003336 (OMIM: 601661) SUMO-conjugating enzyme U ( 158) 274 71.8 5.7e-13 >>NP_008950 (OMIM: 605574) ubiquitin-conjugating enzyme (179 aa) initn: 1197 init1: 1197 opt: 1197 Z-score: 1518.9 bits: 287.6 E(85289): 7.3e-78 Smith-Waterman score: 1197; 100.0% identity (100.0% similar) in 179 aa overlap (1-179:1-179) 10 20 30 40 50 60 pF1KE3 MASQNRDPAATSVAAARKGAEPSGGAARGPVGKRLQQELMTLMMSGDKGISAFPESDNLF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_008 MASQNRDPAATSVAAARKGAEPSGGAARGPVGKRLQQELMTLMMSGDKGISAFPESDNLF 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 KWVGTIHGAAGTVYEDLRYKLSLEFPSGYPYNAPTVKFLTPCYHPNVDTQGNICLDILKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_008 KWVGTIHGAAGTVYEDLRYKLSLEFPSGYPYNAPTVKFLTPCYHPNVDTQGNICLDILKE 70 80 90 100 110 120 130 140 150 160 170 pF1KE3 KWSALYDVRTILLSIQSLLGEPNIDSPLNTHAAELWKNPTAFKKYLQETYSKQVTSQEP ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_008 KWSALYDVRTILLSIQSLLGEPNIDSPLNTHAAELWKNPTAFKKYLQETYSKQVTSQEP 130 140 150 160 170 >>NP_861517 (OMIM: 605574) ubiquitin-conjugating enzyme (140 aa) initn: 947 init1: 947 opt: 947 Z-score: 1204.7 bits: 229.1 E(85289): 2.3e-60 Smith-Waterman score: 947; 100.0% identity (100.0% similar) in 140 aa overlap (40-179:1-140) 10 20 30 40 50 60 pF1KE3 ATSVAAARKGAEPSGGAARGPVGKRLQQELMTLMMSGDKGISAFPESDNLFKWVGTIHGA :::::::::::::::::::::::::::::: NP_861 MTLMMSGDKGISAFPESDNLFKWVGTIHGA 10 20 30 70 80 90 100 110 120 pF1KE3 AGTVYEDLRYKLSLEFPSGYPYNAPTVKFLTPCYHPNVDTQGNICLDILKEKWSALYDVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_861 AGTVYEDLRYKLSLEFPSGYPYNAPTVKFLTPCYHPNVDTQGNICLDILKEKWSALYDVR 40 50 60 70 80 90 130 140 150 160 170 pF1KE3 TILLSIQSLLGEPNIDSPLNTHAAELWKNPTAFKKYLQETYSKQVTSQEP :::::::::::::::::::::::::::::::::::::::::::::::::: NP_861 TILLSIQSLLGEPNIDSPLNTHAAELWKNPTAFKKYLQETYSKQVTSQEP 100 110 120 130 140 >>NP_861516 (OMIM: 605574) ubiquitin-conjugating enzyme (150 aa) initn: 985 init1: 724 opt: 724 Z-score: 922.6 bits: 177.0 E(85289): 1.2e-44 Smith-Waterman score: 930; 83.8% identity (83.8% similar) in 179 aa overlap (1-179:1-150) 10 20 30 40 50 60 pF1KE3 MASQNRDPAATSVAAARKGAEPSGGAARGPVGKRLQQELMTLMMSGDKGISAFPESDNLF ::::::::::::::::::::::::::::::::::::::::::: NP_861 MASQNRDPAATSVAAARKGAEPSGGAARGPVGKRLQQELMTLM----------------- 10 20 30 40 70 80 90 100 110 120 pF1KE3 KWVGTIHGAAGTVYEDLRYKLSLEFPSGYPYNAPTVKFLTPCYHPNVDTQGNICLDILKE :::::::::::::::::::::::::::::::::::::::::::::::: NP_861 ------------VYEDLRYKLSLEFPSGYPYNAPTVKFLTPCYHPNVDTQGNICLDILKE 50 60 70 80 90 130 140 150 160 170 pF1KE3 KWSALYDVRTILLSIQSLLGEPNIDSPLNTHAAELWKNPTAFKKYLQETYSKQVTSQEP ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_861 KWSALYDVRTILLSIQSLLGEPNIDSPLNTHAAELWKNPTAFKKYLQETYSKQVTSQEP 100 110 120 130 140 150 >>NP_861515 (OMIM: 605574) ubiquitin-conjugating enzyme (161 aa) initn: 732 init1: 483 opt: 483 Z-score: 617.7 bits: 120.7 E(85289): 1.1e-27 Smith-Waterman score: 714; 67.6% identity (76.9% similar) in 182 aa overlap (1-179:1-161) 10 20 30 40 50 60 pF1KE3 MASQNRDPAATSVAAARKGAEPSGGAARGPVGKRLQQELMTLMMSGDKGISAFPESDNLF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_861 MASQNRDPAATSVAAARKGAEPSGGAARGPVGKRLQQELMTLMMSGDKGISAFPESDNLF 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 KWVGTIHGAAGTVYEDLRYKLSLEFPSGYPYNAPTVKFLTPCYHPNVDTQGNICLDILKE ::::::::::::. ..: . .. . :: . . : :. NP_861 KWVGTIHGAAGTAVGSIRTSSTVCLLSGPRETQDSSKPLV-------------------- 70 80 90 100 130 140 150 160 170 pF1KE3 KWSALYDVRTIL-LSIQSLLG--EPNIDSPLNTHAAELWKNPTAFKKYLQETYSKQVTSQ :. .:.: .: :..: .: ::::::::::::::::::::::::::::::::::::: NP_861 -WGLGWDMRLLLELTLQLFLQMPEPNIDSPLNTHAAELWKNPTAFKKYLQETYSKQVTSQ 110 120 130 140 150 pF1KE3 EP :: NP_861 EP 160 >>NP_001268671 (OMIM: 605574) ubiquitin-conjugating enzy (79 aa) initn: 473 init1: 473 opt: 473 Z-score: 609.6 bits: 118.2 E(85289): 3.2e-27 Smith-Waterman score: 473; 100.0% identity (100.0% similar) in 72 aa overlap (1-72:1-72) 10 20 30 40 50 60 pF1KE3 MASQNRDPAATSVAAARKGAEPSGGAARGPVGKRLQQELMTLMMSGDKGISAFPESDNLF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MASQNRDPAATSVAAARKGAEPSGGAARGPVGKRLQQELMTLMMSGDKGISAFPESDNLF 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 KWVGTIHGAAGTVYEDLRYKLSLEFPSGYPYNAPTVKFLTPCYHPNVDTQGNICLDILKE :::::::::::: NP_001 KWVGTIHGAAGTNPTLIVP 70 >>NP_003328 (OMIM: 179095) ubiquitin-conjugating enzyme (152 aa) initn: 346 init1: 331 opt: 411 Z-score: 527.2 bits: 103.9 E(85289): 1.3e-22 Smith-Waterman score: 411; 44.9% identity (72.8% similar) in 136 aa overlap (30-164:4-139) 10 20 30 40 50 60 pF1KE3 MASQNRDPAATSVAAARKGAEPSGGAARGPVGKRLQQELMTLMMSGDKGISAFPESDNLF :. .::.... :. . :.:. : .:.. NP_003 MSTPARRRLMRDFKRLQEDPPVGVSGAPSENNIM 10 20 30 70 80 90 100 110 120 pF1KE3 KWVGTIHGAAGTVYEDLRYKLSLEFPSGYPYNAPTVKFLTPCYHPNVDTQGNICLDILKE .: ..: : :: .:: .:: .:: :: . :::.::. .:::: ..:.::::::.. NP_003 QWNAVIFGPEGTPFEDGTFKLVIEFSEEYPNKPPTVRFLSKMFHPNVYADGSICLDILQN 40 50 60 70 80 90 130 140 150 160 170 pF1KE3 KWSALYDVRTILLSIQSLLGEPNIDSPLNTHAAELWK-NPTAFKKYLQETYSKQVTSQEP .:: ::: .:: :::::: ::: .:: :..::.:.. : ..: NP_003 RWSPTYDVSSILTSIQSLLDEPNPNSPANSQAAQLYQENKREYEKRVSAIVEQSWNDS 100 110 120 130 140 150 >>NP_003327 (OMIM: 300860,312180) ubiquitin-conjugating (152 aa) initn: 347 init1: 331 opt: 408 Z-score: 523.4 bits: 103.2 E(85289): 2.1e-22 Smith-Waterman score: 408; 44.1% identity (72.8% similar) in 136 aa overlap (30-164:4-139) 10 20 30 40 50 60 pF1KE3 MASQNRDPAATSVAAARKGAEPSGGAARGPVGKRLQQELMTLMMSGDKGISAFPESDNLF :. .::.... :. . :.:. : .:.. NP_003 MSTPARRRLMRDFKRLQEDPPAGVSGAPSENNIM 10 20 30 70 80 90 100 110 120 pF1KE3 KWVGTIHGAAGTVYEDLRYKLSLEFPSGYPYNAPTVKFLTPCYHPNVDTQGNICLDILKE : ..: : :: .:: .::..:: :: . :::.:.. .:::: ..:.::::::.. NP_003 VWNAVIFGPEGTPFEDGTFKLTIEFTEEYPNKPPTVRFVSKMFHPNVYADGSICLDILQN 40 50 60 70 80 90 130 140 150 160 170 pF1KE3 KWSALYDVRTILLSIQSLLGEPNIDSPLNTHAAELWK-NPTAFKKYLQETYSKQVTSQEP .:: ::: .:: :::::: ::: .:: :..::.:.. : ..: NP_003 RWSPTYDVSSILTSIQSLLDEPNPNSPANSQAAQLYQENKREYEKRVSAIVEQSWRDC 100 110 120 130 140 150 >>NP_003339 (OMIM: 603679) ubiquitin-conjugating enzyme (152 aa) initn: 351 init1: 318 opt: 366 Z-score: 470.3 bits: 93.3 E(85289): 1.9e-19 Smith-Waterman score: 366; 45.0% identity (65.9% similar) in 129 aa overlap (33-161:6-134) 10 20 30 40 50 60 pF1KE3 SQNRDPAATSVAAARKGAEPSGGAARGPVGKRLQQELMTLMMSGDKGISAFPESDNLFKW .:. .: . :. ::.: :. .: . NP_003 MAGLPRRIIKETQRLLAEPVPGIKAEPDESNARYF 10 20 30 70 80 90 100 110 120 pF1KE3 VGTIHGAAGTVYEDLRYKLSLEFPSGYPYNAPTVKFLTPCYHPNVDTQGNICLDILKEKW .: : . .: .:: : .: ::. :: :.:.: :::::: : :::::::.:: NP_003 HVVIAGPQDSPFEGGTFKLELFLPEEYPMAAPKVRFMTKIYHPNVDKLGRICLDILKDKW 40 50 60 70 80 90 130 140 150 160 170 pF1KE3 SALYDVRTILLSIQSLLGEPNIDSPLNTHAAELWKNPTAFKKYLQETYSKQVTSQEP : ..::.:::::.::. :: :.:: . .:: ::. : NP_003 SPALQIRTVLLSIQALLSAPNPDDPLANDVAEQWKTNEAQAIETARAWTRLYAMNNI 100 110 120 130 140 150 >>NP_003329 (OMIM: 602961) ubiquitin-conjugating enzyme (147 aa) initn: 349 init1: 349 opt: 362 Z-score: 465.5 bits: 92.4 E(85289): 3.4e-19 Smith-Waterman score: 362; 39.0% identity (66.7% similar) in 141 aa overlap (33-172:4-144) 10 20 30 40 50 60 pF1KE3 SQNRDPAATSVAAARKGAEPSGGAARGPVGKRLQQELMTLMMSGDKGISAFPESDNLFKW ::.:.:: :. . :: : .:.::.: NP_003 MALKRIQKELSDLQRDPPAHCSAGPVGDDLFHW 10 20 30 70 80 90 100 110 120 pF1KE3 VGTIHGAAGTVYEDLRYKLSLEFPSGYPYNAPTVKFLTPCYHPNVDTQGNICLDILKEKW .:: : ..:. . :...::. ::.. : . : : ::::....:.::::::. .: NP_003 QATIMGPPDSAYQGGVFFLTVHFPTDYPFKPPKIAFTTKIYHPNINSNGSICLDILRSQW 40 50 60 70 80 90 130 140 150 160 170 pF1KE3 SALYDVRTILLSIQSLLGEPNIDSPLNTHAAELWK-NPTAFKKYLQETYSKQVTSQEP : : .:::: ::: .:: :.:: :...: . .... .: .: NP_003 SPALTVSKVLLSICSLLCDPNPDDPLVPDIAQIYKSDKEKYNRHAREWTQKYAM 100 110 120 130 140 >>NP_001269090 (OMIM: 300860,312180) ubiquitin-conjugati (119 aa) initn: 331 init1: 331 opt: 356 Z-score: 459.2 bits: 90.9 E(85289): 7.7e-19 Smith-Waterman score: 356; 50.0% identity (75.0% similar) in 104 aa overlap (62-164:3-106) 40 50 60 70 80 90 pF1KE3 GKRLQQELMTLMMSGDKGISAFPESDNLFKWVGTIHGAAGTVYEDLRYKLSLEFPSGYPY : ..: : :: .:: .::..:: :: NP_001 MVWNAVIFGPEGTPFEDGTFKLTIEFTEEYPN 10 20 30 100 110 120 130 140 150 pF1KE3 NAPTVKFLTPCYHPNVDTQGNICLDILKEKWSALYDVRTILLSIQSLLGEPNIDSPLNTH . :::.:.. .:::: ..:.::::::...:: ::: .:: :::::: ::: .:: :.. NP_001 KPPTVRFVSKMFHPNVYADGSICLDILQNRWSPTYDVSSILTSIQSLLDEPNPNSPANSQ 40 50 60 70 80 90 160 170 pF1KE3 AAELWK-NPTAFKKYLQETYSKQVTSQEP ::.:.. : ..: NP_001 AAQLYQENKREYEKRVSAIVEQSWRDC 100 110 179 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 22:49:28 2016 done: Sun Nov 6 22:49:29 2016 Total Scan time: 5.850 Total Display time: -0.010 Function used was FASTA [36.3.4 Apr, 2011]