FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB0412, 824 aa 1>>>pF1KB0412 824 - 824 aa - 824 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 7.8999+/-0.000396; mu= 7.9320+/- 0.025 mean_var=128.0277+/-25.514, 0's: 0 Z-trim(115.2): 135 B-trim: 323 in 1/54 Lambda= 0.113350 statistics sampled from 25309 (25446) to 25309 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.643), E-opt: 0.2 (0.298), width: 16 Scan time: 11.520 The best scores are: opt bits E(85289) NP_009135 (OMIM: 606168) probable ATP-dependent RN ( 824) 5448 902.9 0 NP_001958 (OMIM: 601102) eukaryotic initiation fac ( 407) 834 148.3 6.7e-35 NP_001407 (OMIM: 602641) eukaryotic initiation fac ( 406) 825 146.8 1.9e-34 NP_055555 (OMIM: 268305,608546) eukaryotic initiat ( 411) 798 142.4 4e-33 NP_542165 (OMIM: 142560) spliceosome RNA helicase ( 428) 782 139.8 2.5e-32 NP_004631 (OMIM: 142560) spliceosome RNA helicase ( 428) 782 139.8 2.5e-32 NP_009173 (OMIM: 605812) ATP-dependent RNA helicas ( 479) 679 122.9 3.3e-27 XP_011521136 (OMIM: 605812) PREDICTED: ATP-depende ( 484) 679 122.9 3.3e-27 XP_011521134 (OMIM: 605812) PREDICTED: ATP-depende ( 539) 679 123.0 3.7e-27 NP_001191439 (OMIM: 602641) eukaryotic initiation ( 347) 653 118.6 4.7e-26 NP_001244103 (OMIM: 605812) ATP-dependent RNA heli ( 370) 643 117.0 1.6e-25 XP_016878379 (OMIM: 605812) PREDICTED: ATP-depende ( 370) 643 117.0 1.6e-25 XP_006721190 (OMIM: 605812) PREDICTED: ATP-depende ( 370) 643 117.0 1.6e-25 NP_001244102 (OMIM: 605812) ATP-dependent RNA heli ( 370) 643 117.0 1.6e-25 NP_001014449 (OMIM: 605812) ATP-dependent RNA heli ( 370) 643 117.0 1.6e-25 XP_011541093 (OMIM: 607663) PREDICTED: ATP-depende ( 482) 620 113.3 2.7e-24 NP_037396 (OMIM: 607663) ATP-dependent RNA helicas ( 483) 620 113.3 2.7e-24 XP_011541092 (OMIM: 607663) PREDICTED: ATP-depende ( 486) 620 113.3 2.7e-24 NP_060365 (OMIM: 616621) probable ATP-dependent RN ( 796) 613 112.2 9.3e-24 NP_001014451 (OMIM: 605812) ATP-dependent RNA heli ( 448) 603 110.5 1.7e-23 NP_001244101 (OMIM: 605812) ATP-dependent RNA heli ( 453) 603 110.5 1.7e-23 XP_016866492 (OMIM: 606286) PREDICTED: probable AT ( 439) 602 110.3 1.9e-23 XP_011521135 (OMIM: 605812) PREDICTED: ATP-depende ( 508) 603 110.5 1.9e-23 XP_011534230 (OMIM: 606286) PREDICTED: probable AT ( 529) 602 110.4 2.2e-23 XP_011534229 (OMIM: 606286) PREDICTED: probable AT ( 529) 602 110.4 2.2e-23 XP_011534228 (OMIM: 606286) PREDICTED: probable AT ( 604) 602 110.4 2.5e-23 NP_061135 (OMIM: 606286) probable ATP-dependent RN ( 648) 602 110.4 2.7e-23 NP_001317367 (OMIM: 607663) ATP-dependent RNA heli ( 369) 581 106.9 1.7e-22 NP_057439 (OMIM: 615428) probable ATP-dependent RN ( 455) 579 106.6 2.6e-22 XP_011523824 (OMIM: 268305,608546) PREDICTED: euka ( 390) 557 103.0 2.8e-21 NP_006377 (OMIM: 608469) probable ATP-dependent RN ( 729) 552 102.2 8.6e-21 NP_001091974 (OMIM: 608469) probable ATP-dependent ( 731) 552 102.2 8.6e-21 NP_001026895 (OMIM: 174300,615464) probable ATP-de ( 619) 548 101.6 1.2e-20 XP_016857920 (OMIM: 174300,615464) PREDICTED: prob ( 619) 548 101.6 1.2e-20 XP_011508337 (OMIM: 174300,615464) PREDICTED: prob ( 619) 548 101.6 1.2e-20 XP_016857921 (OMIM: 174300,615464) PREDICTED: prob ( 619) 548 101.6 1.2e-20 NP_001244104 (OMIM: 605812) ATP-dependent RNA heli ( 328) 539 100.0 1.8e-20 NP_076977 (OMIM: 611665) ATP-dependent RNA helicas ( 881) 545 101.1 2.3e-20 NP_001104792 (OMIM: 611665) ATP-dependent RNA heli ( 882) 545 101.1 2.3e-20 NP_001243839 (OMIM: 606357) nucleolar RNA helicase ( 715) 526 98.0 1.6e-19 NP_004719 (OMIM: 606357) nucleolar RNA helicase 2 ( 783) 526 98.0 1.8e-19 NP_001307524 (OMIM: 180630) probable ATP-dependent ( 614) 510 95.3 8.6e-19 NP_001307526 (OMIM: 180630) probable ATP-dependent ( 614) 510 95.3 8.6e-19 NP_004387 (OMIM: 180630) probable ATP-dependent RN ( 614) 510 95.3 8.6e-19 NP_001307525 (OMIM: 180630) probable ATP-dependent ( 614) 510 95.3 8.6e-19 NP_001307110 (OMIM: 174300,615464) probable ATP-de ( 567) 491 92.2 6.9e-18 XP_006711625 (OMIM: 174300,615464) PREDICTED: prob ( 557) 489 91.9 8.6e-18 NP_001160006 (OMIM: 605281) probable ATP-dependent ( 575) 487 91.6 1.1e-17 XP_011541799 (OMIM: 605281) PREDICTED: probable AT ( 678) 487 91.6 1.3e-17 NP_001136021 (OMIM: 605281) probable ATP-dependent ( 690) 487 91.6 1.3e-17 >>NP_009135 (OMIM: 606168) probable ATP-dependent RNA he (824 aa) initn: 5448 init1: 5448 opt: 5448 Z-score: 4820.4 bits: 902.9 E(85289): 0 Smith-Waterman score: 5448; 99.8% identity (99.8% similar) in 824 aa overlap (1-824:1-824) 10 20 30 40 50 60 pF1KB0 MAAAFEASGALAAVATAMPAEHVAVQVPAPEPTPGPVRILRTAQDLSSPRTRTGDVLLAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_009 MAAAFEASGALAAVATAMPAEHVAVQVPAPEPTPGPVRILRTAQDLSSPRTRTGDVLLAE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB0 PADFESLLLSRPVLEGLRAAGFERPSPVQLKAIPLGRCGLDLIVQAKSGTGKTCVFSTIA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_009 PADFESLLLSRPVLEGLRAAGFERPSPVQLKAIPLGRCGLDLIVQAKSGTGKTCVFSTIA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB0 LDSLVLENLSTQILILAPTREIAVQIHSVITAIGIKMEGLECHVFIGGTPLSQDKTRLKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_009 LDSLVLENLSTQILILAPTREIAVQIHSVITAIGIKMEGLECHVFIGGTPLSQDKTRLKK 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB0 CHIAVGSPGRIKQLIELDYLNPGSIRLFILDEADKLLEEGSFQEQINWIYSSLPASKQML :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_009 CHIAVGSPGRIKQLIELDYLNPGSIRLFILDEADKLLEEGSFQEQINWIYSSLPASKQML 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB0 AVSATYPEFLANALTKYMRDPTFVRLNSSDPSLIGLKQYYKVVNSYPLAHKVFEEKTQHL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_009 AVSATYPEFLANALTKYMRDPTFVRLNSSDPSLIGLKQYYKVVNSYPLAHKVFEEKTQHL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB0 QELFSRIPFNQALVFSNLHSRAQHLADILSSKGFPAECISGNMNQNQRLDAMAKLKHFHC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_009 QELFSRIPFNQALVFSNLHSRAQHLADILSSKGFPAECISGNMNQNQRLDAMAKLKHFHC 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB0 RVLISTDLTSRGIDAEKVNLVVNLDVPLDWETYMHRIGRAGRFGTLGLTVTYCCRGEEEN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_009 RVLISTDLTSRGIDAEKVNLVVNLDVPLDWETYMHRIGRAGRFGTLGLTVTYCCRGEEEN 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB0 MMMRIAQKCNINLLPLPDPIPSGLMEECVDWDVEVKAAVHTYGIASVPNQPLKKQIQKIE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_009 MMMRIAQKCNINLLPLPDPIPSGLMEECVDWDVEVKAAVHTYGIASVPNQPLKKQIQKIE 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB0 RTLQIQKAHGDHMASSRNNSVSGLSVKSKNNTKQKLPVKSHSECGIIEKATSPKELGCDR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_009 RTLQIQKAHGDHMASSRNNSVSGLSVKSKNNTKQKLPVKSHSECGIIEKATSPKELGCDR 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB0 QSEEQMKNSVQTPVENSTNSQHQVKEALPVSLPQIPCLSSFKIHQPYTLTFAELVEDYEH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_009 QSEEQMKNSVQTPVENSTNSQHQVKEALPVSLPQIPCLSSFKIHQPYTLTFAELVEDYEH 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB0 YIKEGLEKPVEIIRHYTGPGDQTVNPQNGFVRNKVTEQRVPVLASSSQSGDSESDSDSYS ::::::::::::::::::::::::::::::::::: :::::::::::::::::::::::: NP_009 YIKEGLEKPVEIIRHYTGPGDQTVNPQNGFVRNKVIEQRVPVLASSSQSGDSESDSDSYS 610 620 630 640 650 660 670 680 690 700 710 720 pF1KB0 SRTSSQSKGNKSYLEGSSDNQLKDSESTPVDDRISLEQPPNGSDTPNPEKYQESPGIQMK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_009 SRTSSQSKGNKSYLEGSSDNQLKDSESTPVDDRISLEQPPNGSDTPNPEKYQESPGIQMK 670 680 690 700 710 720 730 740 750 760 770 780 pF1KB0 TRLKEGASQRAKQSRRNLPRRSSFRLQTGAQEDDWYDCHREIRLSFSDTYQDYEEYWRAY :::::::::::::::::::::::::::: ::::::::::::::::::::::::::::::: NP_009 TRLKEGASQRAKQSRRNLPRRSSFRLQTEAQEDDWYDCHREIRLSFSDTYQDYEEYWRAY 730 740 750 760 770 780 790 800 810 820 pF1KB0 YRAWQEYYAAASHSYYWNAQRHPSWMAAYHMNTIYLQEMMHSNQ :::::::::::::::::::::::::::::::::::::::::::: NP_009 YRAWQEYYAAASHSYYWNAQRHPSWMAAYHMNTIYLQEMMHSNQ 790 800 810 820 >>NP_001958 (OMIM: 601102) eukaryotic initiation factor (407 aa) initn: 640 init1: 270 opt: 834 Z-score: 747.5 bits: 148.3 E(85289): 6.7e-35 Smith-Waterman score: 835; 38.7% identity (70.3% similar) in 364 aa overlap (63-424:34-386) 40 50 60 70 80 90 pF1KB0 TPGPVRILRTAQDLSSPRTRTGDVLLAEPADFESLLLSRPVLEGLRAAGFERPSPVQLKA .:... :.. .:.:. : :::.:: .: .: NP_001 GSADYNREHGGPEGMDPDGVIESNWNEIVDNFDDMNLKESLLRGIYAYGFEKPSAIQQRA 10 20 30 40 50 60 100 110 120 130 140 150 pF1KB0 IPLGRCGLDLIVQAKSGTGKTCVFSTIALDSLVLENLSTQILILAPTREIAVQIHSVITA : : :.:.::.:::::: .:. :..: .: :: :.::::::.: ::..:: : NP_001 IIPCIKGYDVIAQAQSGTGKTATFAISILQQLEIEFKETQALVLAPTRELAQQIQKVILA 70 80 90 100 110 120 160 170 180 190 200 210 pF1KB0 IGIKMEGLECHVFIGGTPLSQDKTRLKKC--HIAVGSPGRIKQLIELDYLNPGSIRLFIL .: : : ::. :::: . .. .:. ::.::.:::. .... ::.: :..:.: NP_001 LGDYM-GATCHACIGGTNVRNEMQKLQAEAPHIVVGTPGRVFDMLNRRYLSPKWIKMFVL 130 140 150 160 170 180 220 230 240 250 260 270 pF1KB0 DEADKLLEEGSFQEQINWIYSSLPASKQMLAVSATYPEFLANALTKYMRDPTFVRLNSSD ::::..: .: :..:: :...: .: :.. .:::.: . .. :.:::: . ... . NP_001 DEADEMLSRG-FKDQIYEIFQKLNTSIQVVLLSATMPTDVLEVTKKFMRDPIRILVKKEE 190 200 210 220 230 240 280 290 300 310 320 330 pF1KB0 PSLIGLKQYYKVVNSYPLAHKVFEEKTQHLQELFSRIPFNQALVFSNLHSRAQHLADILS .: :.::.: :. : : . : .:. . ..::..: : . ... :.. . NP_001 LTLEGIKQFYINVERE-------EWKLDTLCDLYETLTITQAVIFLNTRRKVDWLTEKMH 250 260 270 280 290 340 350 360 370 380 390 pF1KB0 SKGFPAECISGNMNQNQRLDAMAKLKHFHCRVLISTDLTSRGIDAEKVNLVVNLDVPLDW .. : . . :.:.:..: : ... ::::.::: .::::...:.::.: :.: . NP_001 ARDFTVSALHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNR 300 310 320 330 340 350 400 410 420 430 440 450 pF1KB0 ETYMHRIGRAGRFGTLGLTVTYCCRGEEENMMMRIAQKCNINLLPLPDPIPSGLMEECVD :.:.:::::.:::: :..... ::.. ..: NP_001 ENYIHRIGRGGRFGRKGVAINFVT--EEDKRILRDIETFYNTTVEEMPMNVADLI 360 370 380 390 400 460 470 480 490 500 510 pF1KB0 WDVEVKAAVHTYGIASVPNQPLKKQIQKIERTLQIQKAHGDHMASSRNNSVSGLSVKSKN >>NP_001407 (OMIM: 602641) eukaryotic initiation factor (406 aa) initn: 460 init1: 264 opt: 825 Z-score: 739.6 bits: 146.8 E(85289): 1.9e-34 Smith-Waterman score: 826; 37.6% identity (69.3% similar) in 378 aa overlap (64-437:34-399) 40 50 60 70 80 90 pF1KB0 PGPVRILRTAQDLSSPRTRTGDVLLAEPADFESLLLSRPVLEGLRAAGFERPSPVQLKAI :... ::. .:.:. : :::.:: .: .:: NP_001 SQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAI 10 20 30 40 50 60 100 110 120 130 140 150 pF1KB0 -PLGRCGLDLIVQAKSGTGKTCVFSTIALDSLVLENLSTQILILAPTREIAVQIHSVITA : . : :.:.::.:::::: .:. :... :. .:: :.::::::.: ::..:. : NP_001 LPCIK-GYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMA 70 80 90 100 110 120 160 170 180 190 200 210 pF1KB0 IGIKMEGLECHVFIGGTPLSQD--KTRLKKCHIAVGSPGRIKQLIELDYLNPGSIRLFIL .: : : ::. :::: . . : ... :: ::.:::. .... ::.: :..:.: NP_001 LGDYM-GASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVL 130 140 150 160 170 180 220 230 240 250 260 270 pF1KB0 DEADKLLEEGSFQEQINWIYSSLPASKQMLAVSATYPEFLANALTKYMRDPTFVRLNSSD ::::..: .: :..:: :...: .. :.. .:::.: . .. :.:::: . ... . NP_001 DEADEMLSRG-FKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEE 190 200 210 220 230 240 280 290 300 310 320 330 pF1KB0 PSLIGLKQYYKVVNSYPLAHKVFEEKTQHLQELFSRIPFNQALVFSNLHSRAQHLADILS .: :..:.: :. : : . : .:. . ..::..: : . ... :.. . NP_001 LTLEGIRQFYINVERE-------EWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMH 250 260 270 280 290 340 350 360 370 380 390 pF1KB0 SKGFPAECISGNMNQNQRLDAMAKLKHFHCRVLISTDLTSRGIDAEKVNLVVNLDVPLDW .. : . . :.:.:..: : ... ::::.::: .::::...:.::.: :.: . NP_001 ARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNR 300 310 320 330 340 350 400 410 420 430 440 pF1KB0 ETYMHRIGRAGRFGTLGLTVTYCCRGEEENMMMR-IAQKCNINLLPLPDPIPSGLMEECV :.:.:::::.:::: :..... ::.. .: : : .. .: NP_001 ENYIHRIGRGGRFGRKGVAINMVT--EEDKRTLRDIETFYNTSIEEMPLNVADLI 360 370 380 390 400 450 460 470 480 490 500 pF1KB0 DWDVEVKAAVHTYGIASVPNQPLKKQIQKIERTLQIQKAHGDHMASSRNNSVSGLSVKSK >>NP_055555 (OMIM: 268305,608546) eukaryotic initiation (411 aa) initn: 515 init1: 332 opt: 798 Z-score: 715.7 bits: 142.4 E(85289): 4e-33 Smith-Waterman score: 804; 34.2% identity (68.6% similar) in 401 aa overlap (38-437:16-404) 10 20 30 40 50 60 pF1KB0 SGALAAVATAMPAEHVAVQVPAPEPTPGPVRILRTAQDLSSPRTRTGDVLLAEPADFESL :.:. .:... . .:.. . . :. :... NP_055 MATTATMATSGSARKRLLKE-EDMTKVEFETSEEVDVTPT-FDTM 10 20 30 40 70 80 90 100 110 120 pF1KB0 LLSRPVLEGLRAAGFERPSPVQLKAIPLGRCGLDLIVQAKSGTGKTCVFSTIALDSLVLE : . .:.:. : :::.:: .: .:: : :.:.:..:::::: .:: .:. : .. NP_055 GLREDLLRGIYAYGFEKPSAIQQRAIKQIIKGRDVIAQSQSGTGKTATFSISVLQCLDIQ 50 60 70 80 90 100 130 140 150 160 170 180 pF1KB0 NLSTQILILAPTREIAVQIHSVITAIGIKMEGLECHVFIGGTPLSQDKTRLKKC-HIAVG :: ::::::::.::::.. . :.: :. ..::. :::: ...: .: :...: NP_055 VRETQALILAPTRELAVQIQKGLLALGDYMN-VQCHACIGGTNVGEDIRKLDYGQHVVAG 110 120 130 140 150 160 190 200 210 220 230 240 pF1KB0 SPGRIKQLIELDYLNPGSIRLFILDEADKLLEEGSFQEQINWIYSSLPASKQMLAVSATY .:::. ..:. : .:....:::::..:..: :.::: .: :: . :.. .::: NP_055 TPGRVFDMIRRRSLRTRAIKMLVLDEADEMLNKG-FKEQIYDVYRYLPPATQVVLISATL 170 180 190 200 210 220 250 260 270 280 290 300 pF1KB0 PEFLANALTKYMRDPTFVRLNSSDPSLIGLKQYYKVVNSYPLAHKVFEEKTQHLQELFSR :. . . .:.: :: . .. .. .: :.::.. .:. : : . : .:.. NP_055 PHEILEMTNKFMTDPIRILVKRDELTLEGIKQFFVAVERE-------EWKFDTLCDLYDT 230 240 250 260 270 310 320 330 340 350 360 pF1KB0 IPFNQALVFSNLHSRAQHLADILSSKGFPAECISGNMNQNQRLDAMAKLKHFHCRVLIST . ..::..: : . ... :.. . .: . . :.: :..: . : ... :::::: NP_055 LTITQAVIFCNTKRKVDWLTEKMREANFTVSSMHGDMPQKERESIMKEFRSGASRVLIST 280 290 300 310 320 330 370 380 390 400 410 420 pF1KB0 DLTSRGIDAEKVNLVVNLDVPLDWETYMHRIGRAGRFGTLGLTVTYCCRGEEENMMMRIA :. .::.:. .:.:..: :.: . : :.:::::.::.: :..... .... .. : NP_055 DVWARGLDVPQVSLIINYDLPNNRELYIHRIGRSGRYGRKGVAINFV-KNDDIRILRDIE 340 350 360 370 380 390 430 440 450 460 470 480 pF1KB0 QKCNINLLPLPDPIPSGLMEECVDWDVEVKAAVHTYGIASVPNQPLKKQIQKIERTLQIQ : . .. .: NP_055 QYYSTQIDEMPMNVADLI 400 410 >>NP_542165 (OMIM: 142560) spliceosome RNA helicase DDX3 (428 aa) initn: 793 init1: 366 opt: 782 Z-score: 701.2 bits: 139.8 E(85289): 2.5e-32 Smith-Waterman score: 782; 35.2% identity (66.8% similar) in 398 aa overlap (54-447:37-426) 30 40 50 60 70 80 pF1KB0 AVQVPAPEPTPGPVRILRTAQDLSSPRTRTGDVLLAEPADFESLLLSRPVLEGLRAAGFE :. . . . :...::. .:... ::: NP_542 DNELLDYEDDEVETAAGGDGAEAPAKKDVKGSYVSIHSSGFRDFLLKPELLRAIVDCGFE 10 20 30 40 50 60 90 100 110 120 130 140 pF1KB0 RPSPVQLKAIPLGRCGLDLIVQAKSGTGKTCVFSTIALDSLVLENLSTQILILAPTREIA .:: :: . :: . :.:.. ::::: ::: :: .:..: . ....:.. :::.: NP_542 HPSEVQHECIPQAILGMDVLCQAKSGMGKTAVFVLATLQQLEPVTGQVSVLVMCHTRELA 70 80 90 100 110 120 150 160 170 180 190 200 pF1KB0 VQIHSVITAIGIKMEGLECHVFIGGTPLSQDKTRLKK-C-HIAVGSPGRIKQLIELDYLN :: . .. : ... ::.:: ...:. ::: : ::.::.:::: : . :: NP_542 FQISKEYERFSKYMPNVKVAVFFGGLSIKKDEEVLKKNCPHIVVGTPGRILALARNKSLN 130 140 150 160 170 180 210 220 230 240 250 260 pF1KB0 PGSIRLFILDEADKLLEEGSFQEQINWIYSSLPASKQMLAVSATYPEFLANALTKYMRDP :. ::::: ::.::. ....... :. : ::.. ::: . . . :.:.:: NP_542 LKHIKHFILDECDKMLEQLDMRRDVQEIFRMTPHEKQVMMFSATLSKEIRPVCRKFMQDP 190 200 210 220 230 240 270 280 290 300 310 320 pF1KB0 TFVRLNSSDP-SLIGLKQYYKVVNSYPLAHKVFEEKTQHLQELFSRIPFNQALVFSNLHS . ... .: ::.::: ... .::...: .:.. . :::...: . . NP_542 MEIFVDDETKLTLHGLQQYYVKLKD--------NEKNRKLFDLLDVLEFNQVVIFVKSVQ 250 260 270 280 290 330 340 350 360 370 380 pF1KB0 RAQHLADILSSKGFPAECISGNMNQNQRLDAMAKLKHFHCRVLISTDLTSRGIDAEKVNL : ::..: ..::: : .: :..::. . ..: :. :.:..:.: .::.: :.::. NP_542 RCIALAQLLVEQNFPAIAIHRGMPQEERLSRYQQFKDFQRRILVATNLFGRGMDIERVNI 300 310 320 330 340 350 390 400 410 420 430 440 pF1KB0 VVNLDVPLDWETYMHRIGRAGRFGTLGLTVTYCCRGEEENMMMRIAQKCNINLLPLPDPI . : :.: : .::.::..::::::: ::..:. .. ... . .. ..:. ::: : NP_542 AFNYDMPEDSDTYLHRVARAGRFGTKGLAITFVSDENDAKILNDVQDRFEVNISELPDEI 360 370 380 390 400 410 450 460 470 480 490 pF1KB0 P-SGLMEECVDWDVEVKAAVHTYGIASVPNQPLKKQIQKIERTLQIQKAHGDHMASSRNN :. .:. NP_542 DISSYIEQTR 420 >>NP_004631 (OMIM: 142560) spliceosome RNA helicase DDX3 (428 aa) initn: 793 init1: 366 opt: 782 Z-score: 701.2 bits: 139.8 E(85289): 2.5e-32 Smith-Waterman score: 782; 35.2% identity (66.8% similar) in 398 aa overlap (54-447:37-426) 30 40 50 60 70 80 pF1KB0 AVQVPAPEPTPGPVRILRTAQDLSSPRTRTGDVLLAEPADFESLLLSRPVLEGLRAAGFE :. . . . :...::. .:... ::: NP_004 DNELLDYEDDEVETAAGGDGAEAPAKKDVKGSYVSIHSSGFRDFLLKPELLRAIVDCGFE 10 20 30 40 50 60 90 100 110 120 130 140 pF1KB0 RPSPVQLKAIPLGRCGLDLIVQAKSGTGKTCVFSTIALDSLVLENLSTQILILAPTREIA .:: :: . :: . :.:.. ::::: ::: :: .:..: . ....:.. :::.: NP_004 HPSEVQHECIPQAILGMDVLCQAKSGMGKTAVFVLATLQQLEPVTGQVSVLVMCHTRELA 70 80 90 100 110 120 150 160 170 180 190 200 pF1KB0 VQIHSVITAIGIKMEGLECHVFIGGTPLSQDKTRLKK-C-HIAVGSPGRIKQLIELDYLN :: . .. : ... ::.:: ...:. ::: : ::.::.:::: : . :: NP_004 FQISKEYERFSKYMPNVKVAVFFGGLSIKKDEEVLKKNCPHIVVGTPGRILALARNKSLN 130 140 150 160 170 180 210 220 230 240 250 260 pF1KB0 PGSIRLFILDEADKLLEEGSFQEQINWIYSSLPASKQMLAVSATYPEFLANALTKYMRDP :. ::::: ::.::. ....... :. : ::.. ::: . . . :.:.:: NP_004 LKHIKHFILDECDKMLEQLDMRRDVQEIFRMTPHEKQVMMFSATLSKEIRPVCRKFMQDP 190 200 210 220 230 240 270 280 290 300 310 320 pF1KB0 TFVRLNSSDP-SLIGLKQYYKVVNSYPLAHKVFEEKTQHLQELFSRIPFNQALVFSNLHS . ... .: ::.::: ... .::...: .:.. . :::...: . . NP_004 MEIFVDDETKLTLHGLQQYYVKLKD--------NEKNRKLFDLLDVLEFNQVVIFVKSVQ 250 260 270 280 290 330 340 350 360 370 380 pF1KB0 RAQHLADILSSKGFPAECISGNMNQNQRLDAMAKLKHFHCRVLISTDLTSRGIDAEKVNL : ::..: ..::: : .: :..::. . ..: :. :.:..:.: .::.: :.::. NP_004 RCIALAQLLVEQNFPAIAIHRGMPQEERLSRYQQFKDFQRRILVATNLFGRGMDIERVNI 300 310 320 330 340 350 390 400 410 420 430 440 pF1KB0 VVNLDVPLDWETYMHRIGRAGRFGTLGLTVTYCCRGEEENMMMRIAQKCNINLLPLPDPI . : :.: : .::.::..::::::: ::..:. .. ... . .. ..:. ::: : NP_004 AFNYDMPEDSDTYLHRVARAGRFGTKGLAITFVSDENDAKILNDVQDRFEVNISELPDEI 360 370 380 390 400 410 450 460 470 480 490 pF1KB0 P-SGLMEECVDWDVEVKAAVHTYGIASVPNQPLKKQIQKIERTLQIQKAHGDHMASSRNN :. .:. NP_004 DISSYIEQTR 420 >>NP_009173 (OMIM: 605812) ATP-dependent RNA helicase DD (479 aa) initn: 644 init1: 215 opt: 679 Z-score: 609.4 bits: 122.9 E(85289): 3.3e-27 Smith-Waterman score: 679; 34.3% identity (64.6% similar) in 376 aa overlap (64-430:94-460) 40 50 60 70 80 90 pF1KB0 PGPVRILRTAQDLSSPRTRTGDVLLAEPADFESLLLSRPVLEGLRAAGFERPSPVQLKAI :: : :. .:.:. : ::.::: .: .:. NP_009 KLIRSNLVDNTNQVEVLQRDPNSPLYSVKSFEELRLKPQLLQGVYAMGFNRPSKIQENAL 70 80 90 100 110 120 100 110 120 130 140 150 pF1KB0 PL--GRCGLDLIVQAKSGTGKTCVFSTIALDSLVLENLSTQILILAPTREIAVQIHSVIT :: .. .::.:..:::::: .: :... : : : :.:: :.:.: .:: NP_009 PLMLAEPPQNLIAQSQSGTGKTAAFVLAMLSQVEPANKYPQCLCLSPTYELALQTGKVIE 130 140 150 160 170 180 160 170 180 190 200 210 pF1KB0 AIGIKMEGLECHVFIGGTPLSQDKTRLKKCHIAVGSPGRIKQLI-ELDYLNPGSIRLFIL .: . :. . :. : . . .... .:..:.:: . . .: ...: .:..:.: NP_009 QMGKFYPELKLAYAVRGNKLERGQ-KISE-QIVIGTPGTVLDWCSKLKFIDPKKIKVFVL 190 200 210 220 230 240 220 230 240 250 260 270 pF1KB0 DEADKLLEEGSFQEQINWIYSSLPASKQMLAVSATYPEFLANALTKYMRDPTFVRLNSSD :::: .. . :.: : :: . ::: :::. . . . : . ::. ..:. . NP_009 DEADVMIATQGHQDQSIRIQRMLPRNCQMLLFSATFEDSVWKFAQKVVPDPNVIKLKREE 250 260 270 280 290 300 280 290 300 310 320 330 pF1KB0 PSLIGLKQYYKVVNSYPLAHKVFEEKTQHLQELFSRIPFNQALVFSNLHSRAQHLADILS .: .:::: . .: .:: : : .:.. : . ::..: . .. :. :: :: NP_009 ETLDTIKQYYVLCSSR-------DEKFQALCNLYGAITIAQAMIFCHTRKTASWLAAELS 310 320 330 340 350 340 350 360 370 380 390 pF1KB0 SKGFPAECISGNMNQNQRLDAMAKLKHFHCRVLISTDLTSRGIDAEKVNLVVNLDVPLDW ..: . .::.: .:: .. .... . .::..:.. .::::.:.:..:.:.:.:.: NP_009 KEGHQVALLSGEMMVEQRAAVIERFREGKEKVLVTTNVCARGIDVEQVSVVINFDLPVDK 360 370 380 390 400 410 400 410 420 430 440 pF1KB0 ------ETYMHRIGRAGRFGTLGLTVTYCCRGEEENMMMRIAQKCNINLLPLPDPIPSGL :::.:::::.:::: ::.:.. . :.. :: .. : NP_009 DGNPDNETYLHRIGRTGRFGKRGLAVNMVDSKHSMNILNRIQEHFNKKIERLDTDDLDEI 420 430 440 450 460 470 450 460 470 480 490 500 pF1KB0 MEECVDWDVEVKAAVHTYGIASVPNQPLKKQIQKIERTLQIQKAHGDHMASSRNNSVSGL NP_009 EKIAN >>XP_011521136 (OMIM: 605812) PREDICTED: ATP-dependent R (484 aa) initn: 644 init1: 215 opt: 679 Z-score: 609.3 bits: 122.9 E(85289): 3.3e-27 Smith-Waterman score: 679; 34.3% identity (64.6% similar) in 376 aa overlap (64-430:99-465) 40 50 60 70 80 90 pF1KB0 PGPVRILRTAQDLSSPRTRTGDVLLAEPADFESLLLSRPVLEGLRAAGFERPSPVQLKAI :: : :. .:.:. : ::.::: .: .:. XP_011 KLIRSNLVDNTNQVEVLQRDPNSPLYSVKSFEELRLKPQLLQGVYAMGFNRPSKIQENAL 70 80 90 100 110 120 100 110 120 130 140 150 pF1KB0 PL--GRCGLDLIVQAKSGTGKTCVFSTIALDSLVLENLSTQILILAPTREIAVQIHSVIT :: .. .::.:..:::::: .: :... : : : :.:: :.:.: .:: XP_011 PLMLAEPPQNLIAQSQSGTGKTAAFVLAMLSQVEPANKYPQCLCLSPTYELALQTGKVIE 130 140 150 160 170 180 160 170 180 190 200 210 pF1KB0 AIGIKMEGLECHVFIGGTPLSQDKTRLKKCHIAVGSPGRIKQLI-ELDYLNPGSIRLFIL .: . :. . :. : . . .... .:..:.:: . . .: ...: .:..:.: XP_011 QMGKFYPELKLAYAVRGNKLERGQ-KISE-QIVIGTPGTVLDWCSKLKFIDPKKIKVFVL 190 200 210 220 230 240 220 230 240 250 260 270 pF1KB0 DEADKLLEEGSFQEQINWIYSSLPASKQMLAVSATYPEFLANALTKYMRDPTFVRLNSSD :::: .. . :.: : :: . ::: :::. . . . : . ::. ..:. . XP_011 DEADVMIATQGHQDQSIRIQRMLPRNCQMLLFSATFEDSVWKFAQKVVPDPNVIKLKREE 250 260 270 280 290 300 280 290 300 310 320 330 pF1KB0 PSLIGLKQYYKVVNSYPLAHKVFEEKTQHLQELFSRIPFNQALVFSNLHSRAQHLADILS .: .:::: . .: .:: : : .:.. : . ::..: . .. :. :: :: XP_011 ETLDTIKQYYVLCSSR-------DEKFQALCNLYGAITIAQAMIFCHTRKTASWLAAELS 310 320 330 340 350 340 350 360 370 380 390 pF1KB0 SKGFPAECISGNMNQNQRLDAMAKLKHFHCRVLISTDLTSRGIDAEKVNLVVNLDVPLDW ..: . .::.: .:: .. .... . .::..:.. .::::.:.:..:.:.:.:.: XP_011 KEGHQVALLSGEMMVEQRAAVIERFREGKEKVLVTTNVCARGIDVEQVSVVINFDLPVDK 360 370 380 390 400 410 400 410 420 430 440 pF1KB0 ------ETYMHRIGRAGRFGTLGLTVTYCCRGEEENMMMRIAQKCNINLLPLPDPIPSGL :::.:::::.:::: ::.:.. . :.. :: .. : XP_011 DGNPDNETYLHRIGRTGRFGKRGLAVNMVDSKHSMNILNRIQEHFNKKIERLDTDDLDEI 420 430 440 450 460 470 450 460 470 480 490 500 pF1KB0 MEECVDWDVEVKAAVHTYGIASVPNQPLKKQIQKIERTLQIQKAHGDHMASSRNNSVSGL XP_011 EKIAN 480 >>XP_011521134 (OMIM: 605812) PREDICTED: ATP-dependent R (539 aa) initn: 644 init1: 215 opt: 679 Z-score: 608.6 bits: 123.0 E(85289): 3.7e-27 Smith-Waterman score: 679; 34.3% identity (64.6% similar) in 376 aa overlap (64-430:154-520) 40 50 60 70 80 90 pF1KB0 PGPVRILRTAQDLSSPRTRTGDVLLAEPADFESLLLSRPVLEGLRAAGFERPSPVQLKAI :: : :. .:.:. : ::.::: .: .:. XP_011 KLIRSNLVDNTNQVEVLQRDPNSPLYSVKSFEELRLKPQLLQGVYAMGFNRPSKIQENAL 130 140 150 160 170 180 100 110 120 130 140 150 pF1KB0 PL--GRCGLDLIVQAKSGTGKTCVFSTIALDSLVLENLSTQILILAPTREIAVQIHSVIT :: .. .::.:..:::::: .: :... : : : :.:: :.:.: .:: XP_011 PLMLAEPPQNLIAQSQSGTGKTAAFVLAMLSQVEPANKYPQCLCLSPTYELALQTGKVIE 190 200 210 220 230 240 160 170 180 190 200 210 pF1KB0 AIGIKMEGLECHVFIGGTPLSQDKTRLKKCHIAVGSPGRIKQLI-ELDYLNPGSIRLFIL .: . :. . :. : . . .... .:..:.:: . . .: ...: .:..:.: XP_011 QMGKFYPELKLAYAVRGNKLERGQ-KISE-QIVIGTPGTVLDWCSKLKFIDPKKIKVFVL 250 260 270 280 290 300 220 230 240 250 260 270 pF1KB0 DEADKLLEEGSFQEQINWIYSSLPASKQMLAVSATYPEFLANALTKYMRDPTFVRLNSSD :::: .. . :.: : :: . ::: :::. . . . : . ::. ..:. . XP_011 DEADVMIATQGHQDQSIRIQRMLPRNCQMLLFSATFEDSVWKFAQKVVPDPNVIKLKREE 310 320 330 340 350 360 280 290 300 310 320 330 pF1KB0 PSLIGLKQYYKVVNSYPLAHKVFEEKTQHLQELFSRIPFNQALVFSNLHSRAQHLADILS .: .:::: . .: .:: : : .:.. : . ::..: . .. :. :: :: XP_011 ETLDTIKQYYVLCSSR-------DEKFQALCNLYGAITIAQAMIFCHTRKTASWLAAELS 370 380 390 400 410 340 350 360 370 380 390 pF1KB0 SKGFPAECISGNMNQNQRLDAMAKLKHFHCRVLISTDLTSRGIDAEKVNLVVNLDVPLDW ..: . .::.: .:: .. .... . .::..:.. .::::.:.:..:.:.:.:.: XP_011 KEGHQVALLSGEMMVEQRAAVIERFREGKEKVLVTTNVCARGIDVEQVSVVINFDLPVDK 420 430 440 450 460 470 400 410 420 430 440 pF1KB0 ------ETYMHRIGRAGRFGTLGLTVTYCCRGEEENMMMRIAQKCNINLLPLPDPIPSGL :::.:::::.:::: ::.:.. . :.. :: .. : XP_011 DGNPDNETYLHRIGRTGRFGKRGLAVNMVDSKHSMNILNRIQEHFNKKIERLDTDDLDEI 480 490 500 510 520 530 450 460 470 480 490 500 pF1KB0 MEECVDWDVEVKAAVHTYGIASVPNQPLKKQIQKIERTLQIQKAHGDHMASSRNNSVSGL XP_011 EKIAN >>NP_001191439 (OMIM: 602641) eukaryotic initiation fact (347 aa) initn: 294 init1: 264 opt: 653 Z-score: 588.7 bits: 118.6 E(85289): 4.7e-26 Smith-Waterman score: 653; 36.7% identity (68.8% similar) in 311 aa overlap (64-371:34-334) 40 50 60 70 80 90 pF1KB0 PGPVRILRTAQDLSSPRTRTGDVLLAEPADFESLLLSRPVLEGLRAAGFERPSPVQLKAI :... ::. .:.:. : :::.:: .: .:: NP_001 SQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAI 10 20 30 40 50 60 100 110 120 130 140 150 pF1KB0 -PLGRCGLDLIVQAKSGTGKTCVFSTIALDSLVLENLSTQILILAPTREIAVQIHSVITA : . : :.:.::.:::::: .:. :... :. .:: :.::::::.: ::..:. : NP_001 LPCIK-GYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMA 70 80 90 100 110 120 160 170 180 190 200 210 pF1KB0 IGIKMEGLECHVFIGGTPLSQD--KTRLKKCHIAVGSPGRIKQLIELDYLNPGSIRLFIL .: : : ::. :::: . . : ... :: ::.:::. .... ::.: :..:.: NP_001 LGDYM-GASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVL 130 140 150 160 170 180 220 230 240 250 260 270 pF1KB0 DEADKLLEEGSFQEQINWIYSSLPASKQMLAVSATYPEFLANALTKYMRDPTFVRLNSSD ::::..: .: :..:: :...: .. :.. .:::.: . .. :.:::: . ... . NP_001 DEADEMLSRG-FKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEE 190 200 210 220 230 240 280 290 300 310 320 330 pF1KB0 PSLIGLKQYYKVVNSYPLAHKVFEEKTQHLQELFSRIPFNQALVFSNLHSRAQHLADILS .: :..:.: :. : : . : .:. . ..::..: : . ... :.. . NP_001 LTLEGIRQFYINVERE-------EWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMH 250 260 270 280 290 340 350 360 370 380 390 pF1KB0 SKGFPAECISGNMNQNQRLDAMAKLKHFHCRVLISTDLTSRGIDAEKVNLVVNLDVPLDW .. : . . :.:.:..: : ... ::::.::: .. NP_001 ARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLGKLYPQNRSRWTVWP 300 310 320 330 340 400 410 420 430 440 450 pF1KB0 ETYMHRIGRAGRFGTLGLTVTYCCRGEEENMMMRIAQKCNINLLPLPDPIPSGLMEECVD 824 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Mon Nov 7 18:51:44 2016 done: Mon Nov 7 18:51:46 2016 Total Scan time: 11.520 Total Display time: 0.060 Function used was FASTA [36.3.4 Apr, 2011]