FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE4314, 323 aa 1>>>pF1KE4314 323 - 323 aa - 323 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.1137+/-0.000377; mu= 16.9663+/- 0.023 mean_var=65.2406+/-13.340, 0's: 0 Z-trim(112.7): 59 B-trim: 0 in 0/50 Lambda= 0.158787 statistics sampled from 21647 (21706) to 21647 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.632), E-opt: 0.2 (0.254), width: 16 Scan time: 7.460 The best scores are: opt bits E(85289) NP_001345 (OMIM: 600450,614279) aldo-keto reductas ( 323) 2171 506.2 3.8e-143 NP_995317 (OMIM: 600450,614279) aldo-keto reductas ( 323) 2171 506.2 3.8e-143 NP_001344 (OMIM: 600449) aldo-keto reductase famil ( 323) 2123 495.2 7.8e-140 NP_003730 (OMIM: 603966) aldo-keto reductase famil ( 323) 1907 445.7 6.1e-125 NP_001240837 (OMIM: 603966) aldo-keto reductase fa ( 323) 1903 444.8 1.2e-124 NP_001809 (OMIM: 600451,614279) aldo-keto reductas ( 323) 1813 424.1 1.9e-118 NP_005980 (OMIM: 235555,604741) 3-oxo-5-beta-stero ( 326) 1313 309.6 5.6e-84 NP_001307956 (OMIM: 600450,614279) aldo-keto reduc ( 297) 1188 280.9 2.2e-75 XP_016871280 (OMIM: 600449) PREDICTED: aldo-keto r ( 297) 1165 275.7 8.4e-74 NP_001177836 (OMIM: 235555,604741) 3-oxo-5-beta-st ( 290) 1163 275.2 1.1e-73 NP_001619 (OMIM: 103880) aldose reductase isoform ( 316) 1064 252.6 8.2e-67 NP_064695 (OMIM: 604707) aldo-keto reductase famil ( 316) 1020 242.5 8.8e-64 XP_011514543 (OMIM: 616336) PREDICTED: aldo-keto r ( 316) 977 232.6 8.2e-61 NP_001074007 (OMIM: 616336) aldo-keto reductase fa ( 344) 952 226.9 4.6e-59 XP_016867713 (OMIM: 616336) PREDICTED: aldo-keto r ( 344) 952 226.9 4.6e-59 NP_001189342 (OMIM: 103830) alcohol dehydrogenase ( 325) 918 219.1 9.8e-57 NP_001189343 (OMIM: 103830) alcohol dehydrogenase ( 325) 918 219.1 9.8e-57 NP_006057 (OMIM: 103830) alcohol dehydrogenase [NA ( 325) 918 219.1 9.8e-57 NP_697021 (OMIM: 103830) alcohol dehydrogenase [NA ( 325) 918 219.1 9.8e-57 NP_001128713 (OMIM: 600450,614279) aldo-keto reduc ( 139) 813 194.8 8.5e-50 NP_001240838 (OMIM: 603966) aldo-keto reductase fa ( 138) 718 173.1 3e-43 XP_011514718 (OMIM: 604707) PREDICTED: aldo-keto r ( 277) 675 163.4 4.9e-40 XP_005250291 (OMIM: 103880) PREDICTED: aldose redu ( 172) 604 147.0 2.6e-35 NP_001333071 (OMIM: 103880) aldose reductase isofo ( 172) 604 147.0 2.6e-35 NP_001177835 (OMIM: 235555,604741) 3-oxo-5-beta-st ( 285) 587 143.3 5.9e-34 XP_011538793 (OMIM: 103830) PREDICTED: alcohol deh ( 214) 555 135.9 7.5e-32 XP_011538794 (OMIM: 103830) PREDICTED: alcohol deh ( 214) 555 135.9 7.5e-32 XP_011514719 (OMIM: 604707) PREDICTED: aldo-keto r ( 175) 425 106.0 5.9e-23 NP_036199 (OMIM: 608477) aflatoxin B1 aldehyde red ( 331) 176 49.1 1.5e-05 XP_011539348 (OMIM: 608477) PREDICTED: aflatoxin B ( 375) 176 49.2 1.6e-05 NP_003680 (OMIM: 603418) aflatoxin B1 aldehyde red ( 359) 167 47.1 6.5e-05 XP_016856203 (OMIM: 608477) PREDICTED: aflatoxin B ( 304) 141 41.1 0.0035 NP_001307908 (OMIM: 603418) aflatoxin B1 aldehyde ( 324) 141 41.1 0.0037 NP_001186791 (OMIM: 601142) voltage-gated potassiu ( 415) 142 41.4 0.0039 XP_016858110 (OMIM: 601142) PREDICTED: voltage-gat ( 435) 142 41.4 0.004 XP_016862660 (OMIM: 601141) PREDICTED: voltage-gat ( 337) 138 40.4 0.0062 XP_011511417 (OMIM: 601141) PREDICTED: voltage-gat ( 337) 138 40.4 0.0062 NP_751891 (OMIM: 601141) voltage-gated potassium c ( 401) 138 40.5 0.0071 NP_003462 (OMIM: 601141) voltage-gated potassium c ( 408) 138 40.5 0.0072 NP_751892 (OMIM: 601141) voltage-gated potassium c ( 419) 138 40.5 0.0074 >>NP_001345 (OMIM: 600450,614279) aldo-keto reductase fa (323 aa) initn: 2171 init1: 2171 opt: 2171 Z-score: 2690.9 bits: 506.2 E(85289): 3.8e-143 Smith-Waterman score: 2171; 100.0% identity (100.0% similar) in 323 aa overlap (1-323:1-323) 10 20 30 40 50 60 pF1KE4 MDSKYQCVKLNDGHFMPVLGFGTYAPAEVPKSKALEAVKLAIEAGFHHIDSAHVYNNEEQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MDSKYQCVKLNDGHFMPVLGFGTYAPAEVPKSKALEAVKLAIEAGFHHIDSAHVYNNEEQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 VGLAIRSKIADGSVKREDIFYTSKLWSNSHRPELVRPALERSLKNLQLDYVDLYLIHFPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VGLAIRSKIADGSVKREDIFYTSKLWSNSHRPELVRPALERSLKNLQLDYVDLYLIHFPV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 SVKPGEEVIPKDENGKILFDTVDLCATWEAMEKCKDAGLAKSIGVSNFNHRLLEMILNKP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SVKPGEEVIPKDENGKILFDTVDLCATWEAMEKCKDAGLAKSIGVSNFNHRLLEMILNKP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 GLKYKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHREEPWVDPNSPVLLEDPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GLKYKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHREEPWVDPNSPVLLEDPV 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 LCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLN 250 260 270 280 290 300 310 320 pF1KE4 RNVRYLTLDIFAGPPNYPFSDEY ::::::::::::::::::::::: NP_001 RNVRYLTLDIFAGPPNYPFSDEY 310 320 >>NP_995317 (OMIM: 600450,614279) aldo-keto reductase fa (323 aa) initn: 2171 init1: 2171 opt: 2171 Z-score: 2690.9 bits: 506.2 E(85289): 3.8e-143 Smith-Waterman score: 2171; 100.0% identity (100.0% similar) in 323 aa overlap (1-323:1-323) 10 20 30 40 50 60 pF1KE4 MDSKYQCVKLNDGHFMPVLGFGTYAPAEVPKSKALEAVKLAIEAGFHHIDSAHVYNNEEQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_995 MDSKYQCVKLNDGHFMPVLGFGTYAPAEVPKSKALEAVKLAIEAGFHHIDSAHVYNNEEQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 VGLAIRSKIADGSVKREDIFYTSKLWSNSHRPELVRPALERSLKNLQLDYVDLYLIHFPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_995 VGLAIRSKIADGSVKREDIFYTSKLWSNSHRPELVRPALERSLKNLQLDYVDLYLIHFPV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 SVKPGEEVIPKDENGKILFDTVDLCATWEAMEKCKDAGLAKSIGVSNFNHRLLEMILNKP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_995 SVKPGEEVIPKDENGKILFDTVDLCATWEAMEKCKDAGLAKSIGVSNFNHRLLEMILNKP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 GLKYKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHREEPWVDPNSPVLLEDPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_995 GLKYKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHREEPWVDPNSPVLLEDPV 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 LCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_995 LCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLN 250 260 270 280 290 300 310 320 pF1KE4 RNVRYLTLDIFAGPPNYPFSDEY ::::::::::::::::::::::: NP_995 RNVRYLTLDIFAGPPNYPFSDEY 310 320 >>NP_001344 (OMIM: 600449) aldo-keto reductase family 1 (323 aa) initn: 2123 init1: 2123 opt: 2123 Z-score: 2631.5 bits: 495.2 E(85289): 7.8e-140 Smith-Waterman score: 2123; 97.8% identity (99.4% similar) in 323 aa overlap (1-323:1-323) 10 20 30 40 50 60 pF1KE4 MDSKYQCVKLNDGHFMPVLGFGTYAPAEVPKSKALEAVKLAIEAGFHHIDSAHVYNNEEQ :::::::::::::::::::::::::::::::::::::.::::::::.::::::.:::::: NP_001 MDSKYQCVKLNDGHFMPVLGFGTYAPAEVPKSKALEATKLAIEAGFRHIDSAHLYNNEEQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 VGLAIRSKIADGSVKREDIFYTSKLWSNSHRPELVRPALERSLKNLQLDYVDLYLIHFPV :::::::::::::::::::::::::: ::::::::::::::::::::::::::::::::: NP_001 VGLAIRSKIADGSVKREDIFYTSKLWCNSHRPELVRPALERSLKNLQLDYVDLYLIHFPV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 SVKPGEEVIPKDENGKILFDTVDLCATWEAMEKCKDAGLAKSIGVSNFNHRLLEMILNKP ::::::::::::::::::::::::::::::.::::::::::::::::::.: :::::::: NP_001 SVKPGEEVIPKDENGKILFDTVDLCATWEAVEKCKDAGLAKSIGVSNFNRRQLEMILNKP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 GLKYKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHREEPWVDPNSPVLLEDPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GLKYKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHREEPWVDPNSPVLLEDPV 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 LCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLN 250 260 270 280 290 300 310 320 pF1KE4 RNVRYLTLDIFAGPPNYPFSDEY ::::::::::::::::::::::: NP_001 RNVRYLTLDIFAGPPNYPFSDEY 310 320 >>NP_003730 (OMIM: 603966) aldo-keto reductase family 1 (323 aa) initn: 1907 init1: 1907 opt: 1907 Z-score: 2364.1 bits: 445.7 E(85289): 6.1e-125 Smith-Waterman score: 1907; 87.0% identity (95.7% similar) in 323 aa overlap (1-323:1-323) 10 20 30 40 50 60 pF1KE4 MDSKYQCVKLNDGHFMPVLGFGTYAPAEVPKSKALEAVKLAIEAGFHHIDSAHVYNNEEQ ::::.::::::::::::::::::::: :::.:::::..::::::::.::::::.:::::: NP_003 MDSKHQCVKLNDGHFMPVLGFGTYAPPEVPRSKALEVTKLAIEAGFRHIDSAHLYNNEEQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 VGLAIRSKIADGSVKREDIFYTSKLWSNSHRPELVRPALERSLKNLQLDYVDLYLIHFPV :::::::::::::::::::::::::::. ::::::::::: :::. ::::::::::: :. NP_003 VGLAIRSKIADGSVKREDIFYTSKLWSTFHRPELVRPALENSLKKAQLDYVDLYLIHSPM 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 SVKPGEEVIPKDENGKILFDTVDLCATWEAMEKCKDAGLAKSIGVSNFNHRLLEMILNKP :.:::::. : :::::..:: ::::.:::::::::::::::::::::::.: :::::::: NP_003 SLKPGEELSPTDENGKVIFDIVDLCTTWEAMEKCKDAGLAKSIGVSNFNRRQLEMILNKP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 GLKYKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHREEPWVDPNSPVLLEDPV ::::::::::::::::::. :::::::::::::::::::::.:.. :::::::::::::: NP_003 GLKYKPVCNQVECHPYFNRSKLLDFCKSKDIVLVAYSALGSQRDKRWVDPNSPVLLEDPV 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 LCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLN :::::::::::::::::::::::::::::::::::::::::::::::::.:.:::::::. NP_003 LCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTAEDMKAIDGLD 250 260 270 280 290 300 310 320 pF1KE4 RNVRYLTLDIFAGPPNYPFSDEY ::..:.. : ::. ::::.:::: NP_003 RNLHYFNSDSFASHPNYPYSDEY 310 320 >>NP_001240837 (OMIM: 603966) aldo-keto reductase family (323 aa) initn: 1903 init1: 1903 opt: 1903 Z-score: 2359.1 bits: 444.8 E(85289): 1.2e-124 Smith-Waterman score: 1903; 86.7% identity (95.7% similar) in 323 aa overlap (1-323:1-323) 10 20 30 40 50 60 pF1KE4 MDSKYQCVKLNDGHFMPVLGFGTYAPAEVPKSKALEAVKLAIEAGFHHIDSAHVYNNEEQ ::::.::.:::::::::::::::::: :::.:::::..::::::::.::::::.:::::: NP_001 MDSKHQCLKLNDGHFMPVLGFGTYAPPEVPRSKALEVTKLAIEAGFRHIDSAHLYNNEEQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 VGLAIRSKIADGSVKREDIFYTSKLWSNSHRPELVRPALERSLKNLQLDYVDLYLIHFPV :::::::::::::::::::::::::::. ::::::::::: :::. ::::::::::: :. NP_001 VGLAIRSKIADGSVKREDIFYTSKLWSTFHRPELVRPALENSLKKAQLDYVDLYLIHSPM 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 SVKPGEEVIPKDENGKILFDTVDLCATWEAMEKCKDAGLAKSIGVSNFNHRLLEMILNKP :.:::::. : :::::..:: ::::.:::::::::::::::::::::::.: :::::::: NP_001 SLKPGEELSPTDENGKVIFDIVDLCTTWEAMEKCKDAGLAKSIGVSNFNRRQLEMILNKP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 GLKYKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHREEPWVDPNSPVLLEDPV ::::::::::::::::::. :::::::::::::::::::::.:.. :::::::::::::: NP_001 GLKYKPVCNQVECHPYFNRSKLLDFCKSKDIVLVAYSALGSQRDKRWVDPNSPVLLEDPV 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 LCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLN :::::::::::::::::::::::::::::::::::::::::::::::::.:.:::::::. NP_001 LCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTAEDMKAIDGLD 250 260 270 280 290 300 310 320 pF1KE4 RNVRYLTLDIFAGPPNYPFSDEY ::..:.. : ::. ::::.:::: NP_001 RNLHYFNSDSFASHPNYPYSDEY 310 320 >>NP_001809 (OMIM: 600451,614279) aldo-keto reductase fa (323 aa) initn: 1813 init1: 1813 opt: 1813 Z-score: 2247.7 bits: 424.1 E(85289): 1.9e-118 Smith-Waterman score: 1813; 81.7% identity (94.4% similar) in 323 aa overlap (1-323:1-323) 10 20 30 40 50 60 pF1KE4 MDSKYQCVKLNDGHFMPVLGFGTYAPAEVPKSKALEAVKLAIEAGFHHIDSAHVYNNEEQ :: ::: :.::::::::::::::::: :::...:.:..::::::::.:::::..:::::: NP_001 MDPKYQRVELNDGHFMPVLGFGTYAPPEVPRNRAVEVTKLAIEAGFRHIDSAYLYNNEEQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 VGLAIRSKIADGSVKREDIFYTSKLWSNSHRPELVRPALERSLKNLQLDYVDLYLIHFPV :::::::::::::::::::::::::: . .:..:.:::: :::.::::::::::.:::. NP_001 VGLAIRSKIADGSVKREDIFYTSKLWCTFFQPQMVQPALESSLKKLQLDYVDLYLLHFPM 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 SVKPGEEVIPKDENGKILFDTVDLCATWEAMEKCKDAGLAKSIGVSNFNHRLLEMILNKP ..:::: .:::::::..:::::: ::::.::::::::::::::::::: : :::::::: NP_001 ALKPGETPLPKDENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFNCRQLEMILNKP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 GLKYKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHREEPWVDPNSPVLLEDPV ::::::::::::::::.:: :::::::::::::::.::::..:.. :::::::::::::: NP_001 GLKYKPVCNQVECHPYLNQSKLLDFCKSKDIVLVAHSALGTQRHKLWVDPNSPVLLEDPV 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 LCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLN ::::::::::::::::::::::::::::::::::::::.:.::::::::::.::..:::: NP_001 LCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRENIQVFEFQLTSEDMKVLDGLN 250 260 270 280 290 300 310 320 pF1KE4 RNVRYLTLDIFAGPPNYPFSDEY :: ::...:.. :.::::::: NP_001 RNYRYVVMDFLMDHPDYPFSDEY 310 320 >>NP_005980 (OMIM: 235555,604741) 3-oxo-5-beta-steroid 4 (326 aa) initn: 1302 init1: 1253 opt: 1313 Z-score: 1628.6 bits: 309.6 E(85289): 5.6e-84 Smith-Waterman score: 1313; 58.4% identity (85.2% similar) in 317 aa overlap (8-323:10-326) 10 20 30 40 50 pF1KE4 MDSKYQCVKLNDGHFMPVLGFGTYA-PAEVPKSKALEAVKLAIEAGFHHIDSAHVYNN . :.::. .:..:.:::. : .::. .::.::..:..:::.:..:.: NP_005 MDLSAASHRIPLSDGNSIPIIGLGTYSEPKSTPKGACATSVKVAIDTGYRHIDGAYIYQN 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE4 EEQVGLAIRSKIADGSVKREDIFYTSKLWSNSHRPELVRPALERSLKNLQLDYVDLYLIH :..:: ::: :::.:.:.:::::: .:::...: ::.:::.:::.:. :::::::::.:. NP_005 EHEVGEAIREKIAEGKVRREDIFYCGKLWATNHVPEMVRPTLERTLRVLQLDYVDLYIIE 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE4 FPVSVKPGEEVIPKDENGKILFDTVDLCATWEAMEKCKDAGLAKSIGVSNFNHRLLEMIL :.. :::.:. :.::::: :. .::::::::: ::::::.::.::::::.: ::.:: NP_005 VPMAFKPGDEIYPRDENGKWLYHKSNLCATWEAMEACKDAGLVKSLGVSNFNRRQLELIL 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE4 NKPGLKYKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHREEPWVDPNSPVLLE ::::::.::: :::::::::.: ::: ::...:::..::: ::. :. ::. .:: ::. NP_005 NKPGLKHKPVSNQVECHPYFTQPKLLKFCQQHDIVITAYSPLGTSRNPIWVNVSSPPLLK 190 200 210 220 230 240 240 250 260 270 280 290 pF1KE4 DPVLCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAID : .: .:.:....: : :.::...::::::. ::.: .::..: :.:.:.:: :::: :. NP_005 DALLNSLGKRYNKTAAQIVLRFNIQRGVVVIPKSFNLERIKENFQIFDFSLTEEEMKDIE 250 260 270 280 290 300 300 310 320 pF1KE4 GLNRNVRYLTLDIFAGPPNYPFSDEY .::.:::.. : .. :.::: ::: NP_005 ALNKNVRFVELLMWRDHPEYPFHDEY 310 320 >>NP_001307956 (OMIM: 600450,614279) aldo-keto reductase (297 aa) initn: 1175 init1: 1175 opt: 1188 Z-score: 1474.4 bits: 280.9 E(85289): 2.2e-75 Smith-Waterman score: 1925; 92.0% identity (92.0% similar) in 323 aa overlap (1-323:1-297) 10 20 30 40 50 60 pF1KE4 MDSKYQCVKLNDGHFMPVLGFGTYAPAEVPKSKALEAVKLAIEAGFHHIDSAHVYNNEEQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MDSKYQCVKLNDGHFMPVLGFGTYAPAEVPKSKALEAVKLAIEAGFHHIDSAHVYNNEEQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 VGLAIRSKIADGSVKREDIFYTSKLWSNSHRPELVRPALERSLKNLQLDYVDLYLIHFPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VGLAIRSKIADGSVKREDIFYTSKLWSNSHRPELVRPALERSLKNLQLDYVDLYLIHFPV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 SVKPGEEVIPKDENGKILFDTVDLCATWEAMEKCKDAGLAKSIGVSNFNHRLLEMILNKP ::: ::::::::::::::::::::::::::::::: NP_001 SVK--------------------------AMEKCKDAGLAKSIGVSNFNHRLLEMILNKP 130 140 150 190 200 210 220 230 240 pF1KE4 GLKYKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHREEPWVDPNSPVLLEDPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GLKYKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHREEPWVDPNSPVLLEDPV 160 170 180 190 200 210 250 260 270 280 290 300 pF1KE4 LCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLN 220 230 240 250 260 270 310 320 pF1KE4 RNVRYLTLDIFAGPPNYPFSDEY ::::::::::::::::::::::: NP_001 RNVRYLTLDIFAGPPNYPFSDEY 280 290 >>XP_016871280 (OMIM: 600449) PREDICTED: aldo-keto reduc (297 aa) initn: 1152 init1: 1152 opt: 1165 Z-score: 1446.0 bits: 275.7 E(85289): 8.4e-74 Smith-Waterman score: 1877; 89.8% identity (91.3% similar) in 323 aa overlap (1-323:1-297) 10 20 30 40 50 60 pF1KE4 MDSKYQCVKLNDGHFMPVLGFGTYAPAEVPKSKALEAVKLAIEAGFHHIDSAHVYNNEEQ :::::::::::::::::::::::::::::::::::::.::::::::.::::::.:::::: XP_016 MDSKYQCVKLNDGHFMPVLGFGTYAPAEVPKSKALEATKLAIEAGFRHIDSAHLYNNEEQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 VGLAIRSKIADGSVKREDIFYTSKLWSNSHRPELVRPALERSLKNLQLDYVDLYLIHFPV :::::::::::::::::::::::::: ::::::::::::::::::::::::::::::::: XP_016 VGLAIRSKIADGSVKREDIFYTSKLWCNSHRPELVRPALERSLKNLQLDYVDLYLIHFPV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 SVKPGEEVIPKDENGKILFDTVDLCATWEAMEKCKDAGLAKSIGVSNFNHRLLEMILNKP ::: :.::::::::::::::::::.: :::::::: XP_016 SVK--------------------------AVEKCKDAGLAKSIGVSNFNRRQLEMILNKP 130 140 150 190 200 210 220 230 240 pF1KE4 GLKYKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHREEPWVDPNSPVLLEDPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GLKYKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHREEPWVDPNSPVLLEDPV 160 170 180 190 200 210 250 260 270 280 290 300 pF1KE4 LCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLN 220 230 240 250 260 270 310 320 pF1KE4 RNVRYLTLDIFAGPPNYPFSDEY ::::::::::::::::::::::: XP_016 RNVRYLTLDIFAGPPNYPFSDEY 280 290 >>NP_001177836 (OMIM: 235555,604741) 3-oxo-5-beta-steroi (290 aa) initn: 1152 init1: 1103 opt: 1163 Z-score: 1443.6 bits: 275.2 E(85289): 1.1e-73 Smith-Waterman score: 1163; 59.2% identity (85.9% similar) in 277 aa overlap (8-283:10-286) 10 20 30 40 50 pF1KE4 MDSKYQCVKLNDGHFMPVLGFGTYA-PAEVPKSKALEAVKLAIEAGFHHIDSAHVYNN . :.::. .:..:.:::. : .::. .::.::..:..:::.:..:.: NP_001 MDLSAASHRIPLSDGNSIPIIGLGTYSEPKSTPKGACATSVKVAIDTGYRHIDGAYIYQN 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE4 EEQVGLAIRSKIADGSVKREDIFYTSKLWSNSHRPELVRPALERSLKNLQLDYVDLYLIH :..:: ::: :::.:.:.:::::: .:::...: ::.:::.:::.:. :::::::::.:. NP_001 EHEVGEAIREKIAEGKVRREDIFYCGKLWATNHVPEMVRPTLERTLRVLQLDYVDLYIIE 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE4 FPVSVKPGEEVIPKDENGKILFDTVDLCATWEAMEKCKDAGLAKSIGVSNFNHRLLEMIL :.. :::.:. :.::::: :. .::::::::: ::::::.::.::::::.: ::.:: NP_001 VPMAFKPGDEIYPRDENGKWLYHKSNLCATWEAMEACKDAGLVKSLGVSNFNRRQLELIL 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE4 NKPGLKYKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHREEPWVDPNSPVLLE ::::::.::: :::::::::.: ::: ::...:::..::: ::. :. ::. .:: ::. NP_001 NKPGLKHKPVSNQVECHPYFTQPKLLKFCQQHDIVITAYSPLGTSRNPIWVNVSSPPLLK 190 200 210 220 230 240 240 250 260 270 280 290 pF1KE4 DPVLCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAID : .: .:.:....: : :.::...::::::. ::.: .::..: :: NP_001 DALLNSLGKRYNKTAAQIVLRFNIQRGVVVIPKSFNLERIKENFQVARSS 250 260 270 280 290 300 310 320 pF1KE4 GLNRNVRYLTLDIFAGPPNYPFSDEY 323 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 23:14:41 2016 done: Sat Nov 5 23:14:42 2016 Total Scan time: 7.460 Total Display time: 0.030 Function used was FASTA [36.3.4 Apr, 2011]