FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE6720, 753 aa 1>>>pF1KE6720 753 - 753 aa - 753 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.4619+/-0.000489; mu= 19.3793+/- 0.030 mean_var=69.9530+/-13.999, 0's: 0 Z-trim(108.4): 302 B-trim: 175 in 1/53 Lambda= 0.153345 statistics sampled from 16230 (16533) to 16230 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.536), E-opt: 0.2 (0.194), width: 16 Scan time: 8.220 The best scores are: opt bits E(85289) NP_004290 (OMIM: 300135,301310) ATP-binding casset ( 753) 4872 1087.9 0 NP_001258625 (OMIM: 300135,301310) ATP-binding cas ( 752) 4853 1083.7 0 NP_001258627 (OMIM: 300135,301310) ATP-binding cas ( 726) 4316 964.8 0 NP_001258626 (OMIM: 300135,301310) ATP-binding cas ( 712) 3827 856.7 0 NP_001258628 (OMIM: 300135,301310) ATP-binding cas ( 713) 3827 856.7 0 NP_005680 (OMIM: 111600,605452,609153,614497,61540 ( 842) 1585 360.7 1.4e-98 NP_036221 (OMIM: 605454) ATP-binding cassette sub- ( 738) 801 187.2 2.1e-46 XP_011542437 (OMIM: 605454) PREDICTED: ATP-binding ( 559) 766 179.4 3.5e-44 NP_001157413 (OMIM: 611785) ATP-binding cassette s (1257) 765 179.4 8.1e-44 XP_011536398 (OMIM: 605453) PREDICTED: ATP-binding ( 766) 754 176.8 2.9e-43 XP_016874592 (OMIM: 605453) PREDICTED: ATP-binding ( 766) 754 176.8 2.9e-43 NP_062571 (OMIM: 605453) ATP-binding cassette sub- ( 766) 754 176.8 2.9e-43 XP_011536397 (OMIM: 605453) PREDICTED: ATP-binding ( 766) 754 176.8 2.9e-43 XP_005253615 (OMIM: 605453) PREDICTED: ATP-binding ( 548) 741 173.9 1.6e-42 XP_011536400 (OMIM: 605453) PREDICTED: ATP-binding ( 548) 741 173.9 1.6e-42 NP_000918 (OMIM: 120080,171050,612244) multidrug r (1280) 743 174.5 2.4e-42 XP_011542438 (OMIM: 605454) PREDICTED: ATP-binding ( 442) 730 171.4 7.2e-42 NP_009119 (OMIM: 605464) ATP-binding cassette sub- ( 718) 726 170.6 2e-41 NP_001269220 (OMIM: 605464) ATP-binding cassette s ( 735) 726 170.6 2e-41 NP_001269222 (OMIM: 605464) ATP-binding cassette s ( 630) 725 170.4 2.1e-41 XP_011514615 (OMIM: 171060,600803,602347,614972) P (1232) 720 169.4 7.9e-41 NP_061338 (OMIM: 171060,600803,602347,614972) phos (1232) 720 169.4 7.9e-41 XP_011514614 (OMIM: 171060,600803,602347,614972) P (1247) 720 169.4 8e-41 XP_011514613 (OMIM: 171060,600803,602347,614972) P (1251) 720 169.4 8e-41 XP_011514612 (OMIM: 171060,600803,602347,614972) P (1259) 720 169.4 8e-41 NP_000434 (OMIM: 171060,600803,602347,614972) phos (1279) 720 169.4 8.1e-41 NP_061337 (OMIM: 171060,600803,602347,614972) phos (1286) 720 169.4 8.2e-41 XP_011514611 (OMIM: 171060,600803,602347,614972) P (1287) 720 169.4 8.2e-41 XP_011514610 (OMIM: 171060,600803,602347,614972) P (1294) 720 169.4 8.2e-41 XP_016867812 (OMIM: 171060,600803,602347,614972) P (1294) 720 169.4 8.2e-41 XP_011510383 (OMIM: 601847,603201,605479) PREDICTE ( 763) 681 160.7 2.1e-38 XP_011514617 (OMIM: 171060,600803,602347,614972) P (1074) 682 161.0 2.4e-38 XP_011510382 (OMIM: 601847,603201,605479) PREDICTE ( 936) 652 154.3 2.1e-36 NP_000584 (OMIM: 170260,604571) antigen peptide tr ( 808) 650 153.8 2.5e-36 XP_016860654 (OMIM: 601847,603201,605479) PREDICTE (1314) 652 154.4 2.8e-36 NP_003733 (OMIM: 601847,603201,605479) bile salt e (1321) 652 154.4 2.8e-36 XP_006712880 (OMIM: 601847,603201,605479) PREDICTE (1335) 652 154.4 2.8e-36 XP_011510380 (OMIM: 601847,603201,605479) PREDICTE (1355) 652 154.4 2.9e-36 XP_011510379 (OMIM: 601847,603201,605479) PREDICTE (1355) 652 154.4 2.9e-36 NP_001278951 (OMIM: 170260,604571) antigen peptide ( 547) 644 152.4 4.6e-36 XP_016860655 (OMIM: 601847,603201,605479) PREDICTE (1098) 637 151.0 2.4e-35 NP_001269221 (OMIM: 605464) ATP-binding cassette s ( 693) 614 145.8 5.6e-34 NP_001229943 (OMIM: 605453) ATP-binding cassette s ( 681) 613 145.6 6.4e-34 NP_982269 (OMIM: 605453) ATP-binding cassette sub- ( 683) 612 145.4 7.5e-34 NP_062570 (OMIM: 605453) ATP-binding cassette sub- ( 723) 600 142.8 5e-33 XP_016860656 (OMIM: 601847,603201,605479) PREDICTE ( 916) 599 142.6 7e-33 NP_001276972 (OMIM: 170261,604571) antigen peptide ( 686) 585 139.4 4.7e-32 NP_000535 (OMIM: 170261,604571) antigen peptide tr ( 703) 580 138.3 1e-31 NP_001306961 (OMIM: 605251) multidrug resistance-a ( 965) 580 138.4 1.4e-31 XP_016874593 (OMIM: 605453) PREDICTED: ATP-binding ( 485) 576 137.3 1.4e-31 >>NP_004290 (OMIM: 300135,301310) ATP-binding cassette s (753 aa) initn: 4872 init1: 4872 opt: 4872 Z-score: 5821.5 bits: 1087.9 E(85289): 0 Smith-Waterman score: 4872; 100.0% identity (100.0% similar) in 753 aa overlap (1-753:1-753) 10 20 30 40 50 60 pF1KE6 MALLAMHSWRWAAAAAAFEKRRHSAILIRPLVSVSGSGPQWRPHQLGALGTARAYQQIPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 MALLAMHSWRWAAAAAAFEKRRHSAILIRPLVSVSGSGPQWRPHQLGALGTARAYQQIPE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 SLKSITWQRLGKGNSGQFLDAAKALQVWPLIEKRTCWHGHAGGGLHTDPKEGLKDVDTRK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 SLKSITWQRLGKGNSGQFLDAAKALQVWPLIEKRTCWHGHAGGGLHTDPKEGLKDVDTRK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 IIKAMLSYVWPKDRPDLRARVAISLGFLGGAKAMNIVVPFMFKYAVDSLNQMSGNMLNLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 IIKAMLSYVWPKDRPDLRARVAISLGFLGGAKAMNIVVPFMFKYAVDSLNQMSGNMLNLS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE6 DAPNTVATMATAVLIGYGVSRAGAAFFNEVRNAVFGKVAQNSIRRIAKNVFLHLHNLDLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 DAPNTVATMATAVLIGYGVSRAGAAFFNEVRNAVFGKVAQNSIRRIAKNVFLHLHNLDLG 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE6 FHLSRQTGALSKAIDRGTRGISFVLSALVFNLLPIMFEVMLVSGVLYYKCGAQFALVTLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 FHLSRQTGALSKAIDRGTRGISFVLSALVFNLLPIMFEVMLVSGVLYYKCGAQFALVTLG 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE6 TLGTYTAFTVAVTRWRTRFRIEMNKADNDAGNAAIDSLLNYETVKYFNNERYEAQRYDGF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 TLGTYTAFTVAVTRWRTRFRIEMNKADNDAGNAAIDSLLNYETVKYFNNERYEAQRYDGF 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE6 LKTYETASLKSTSTLAMLNFGQSAIFSVGLTAIMVLASQGIVAGTLTVGDLVMVNGLLFQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 LKTYETASLKSTSTLAMLNFGQSAIFSVGLTAIMVLASQGIVAGTLTVGDLVMVNGLLFQ 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE6 LSLPLNFLGTVYRETRQALIDMNTLFTLLKVDTQIKDKVMASPLQITPQTATVAFDNVHF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 LSLPLNFLGTVYRETRQALIDMNTLFTLLKVDTQIKDKVMASPLQITPQTATVAFDNVHF 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE6 EYIEGQKVLSGISFEVPAGKKVAIVGGSGSGKSTIVRLLFRFYEPQKGSIYLAGQNIQDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 EYIEGQKVLSGISFEVPAGKKVAIVGGSGSGKSTIVRLLFRFYEPQKGSIYLAGQNIQDV 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE6 SLESLRRAVGVVPQDAVLFHNTIYYNLLYGNISASPEEVYAVAKLAGLHDAILRMPHGYD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 SLESLRRAVGVVPQDAVLFHNTIYYNLLYGNISASPEEVYAVAKLAGLHDAILRMPHGYD 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE6 TQVGERGLKLSGGEKQRVAIARAILKDPPVILYDEATSSLDSITEETILGAMKDVVKHRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 TQVGERGLKLSGGEKQRVAIARAILKDPPVILYDEATSSLDSITEETILGAMKDVVKHRT 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE6 SIFIAHRLSTVVDADEIIVLDQGKVAERGTHHGLLANPHSIYSEMWHTQSSRVQNHDNPK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 SIFIAHRLSTVVDADEIIVLDQGKVAERGTHHGLLANPHSIYSEMWHTQSSRVQNHDNPK 670 680 690 700 710 720 730 740 750 pF1KE6 WEAKKENISKEEERKKLQEEIVNSVKGCGNCSC ::::::::::::::::::::::::::::::::: NP_004 WEAKKENISKEEERKKLQEEIVNSVKGCGNCSC 730 740 750 >>NP_001258625 (OMIM: 300135,301310) ATP-binding cassett (752 aa) initn: 4490 init1: 4490 opt: 4853 Z-score: 5798.8 bits: 1083.7 E(85289): 0 Smith-Waterman score: 4853; 99.9% identity (99.9% similar) in 753 aa overlap (1-753:1-752) 10 20 30 40 50 60 pF1KE6 MALLAMHSWRWAAAAAAFEKRRHSAILIRPLVSVSGSGPQWRPHQLGALGTARAYQQIPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::: ::: NP_001 MALLAMHSWRWAAAAAAFEKRRHSAILIRPLVSVSGSGPQWRPHQLGALGTARAYQ-IPE 10 20 30 40 50 70 80 90 100 110 120 pF1KE6 SLKSITWQRLGKGNSGQFLDAAKALQVWPLIEKRTCWHGHAGGGLHTDPKEGLKDVDTRK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SLKSITWQRLGKGNSGQFLDAAKALQVWPLIEKRTCWHGHAGGGLHTDPKEGLKDVDTRK 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE6 IIKAMLSYVWPKDRPDLRARVAISLGFLGGAKAMNIVVPFMFKYAVDSLNQMSGNMLNLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IIKAMLSYVWPKDRPDLRARVAISLGFLGGAKAMNIVVPFMFKYAVDSLNQMSGNMLNLS 120 130 140 150 160 170 190 200 210 220 230 240 pF1KE6 DAPNTVATMATAVLIGYGVSRAGAAFFNEVRNAVFGKVAQNSIRRIAKNVFLHLHNLDLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DAPNTVATMATAVLIGYGVSRAGAAFFNEVRNAVFGKVAQNSIRRIAKNVFLHLHNLDLG 180 190 200 210 220 230 250 260 270 280 290 300 pF1KE6 FHLSRQTGALSKAIDRGTRGISFVLSALVFNLLPIMFEVMLVSGVLYYKCGAQFALVTLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FHLSRQTGALSKAIDRGTRGISFVLSALVFNLLPIMFEVMLVSGVLYYKCGAQFALVTLG 240 250 260 270 280 290 310 320 330 340 350 360 pF1KE6 TLGTYTAFTVAVTRWRTRFRIEMNKADNDAGNAAIDSLLNYETVKYFNNERYEAQRYDGF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TLGTYTAFTVAVTRWRTRFRIEMNKADNDAGNAAIDSLLNYETVKYFNNERYEAQRYDGF 300 310 320 330 340 350 370 380 390 400 410 420 pF1KE6 LKTYETASLKSTSTLAMLNFGQSAIFSVGLTAIMVLASQGIVAGTLTVGDLVMVNGLLFQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LKTYETASLKSTSTLAMLNFGQSAIFSVGLTAIMVLASQGIVAGTLTVGDLVMVNGLLFQ 360 370 380 390 400 410 430 440 450 460 470 480 pF1KE6 LSLPLNFLGTVYRETRQALIDMNTLFTLLKVDTQIKDKVMASPLQITPQTATVAFDNVHF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LSLPLNFLGTVYRETRQALIDMNTLFTLLKVDTQIKDKVMASPLQITPQTATVAFDNVHF 420 430 440 450 460 470 490 500 510 520 530 540 pF1KE6 EYIEGQKVLSGISFEVPAGKKVAIVGGSGSGKSTIVRLLFRFYEPQKGSIYLAGQNIQDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EYIEGQKVLSGISFEVPAGKKVAIVGGSGSGKSTIVRLLFRFYEPQKGSIYLAGQNIQDV 480 490 500 510 520 530 550 560 570 580 590 600 pF1KE6 SLESLRRAVGVVPQDAVLFHNTIYYNLLYGNISASPEEVYAVAKLAGLHDAILRMPHGYD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SLESLRRAVGVVPQDAVLFHNTIYYNLLYGNISASPEEVYAVAKLAGLHDAILRMPHGYD 540 550 560 570 580 590 610 620 630 640 650 660 pF1KE6 TQVGERGLKLSGGEKQRVAIARAILKDPPVILYDEATSSLDSITEETILGAMKDVVKHRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TQVGERGLKLSGGEKQRVAIARAILKDPPVILYDEATSSLDSITEETILGAMKDVVKHRT 600 610 620 630 640 650 670 680 690 700 710 720 pF1KE6 SIFIAHRLSTVVDADEIIVLDQGKVAERGTHHGLLANPHSIYSEMWHTQSSRVQNHDNPK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SIFIAHRLSTVVDADEIIVLDQGKVAERGTHHGLLANPHSIYSEMWHTQSSRVQNHDNPK 660 670 680 690 700 710 730 740 750 pF1KE6 WEAKKENISKEEERKKLQEEIVNSVKGCGNCSC ::::::::::::::::::::::::::::::::: NP_001 WEAKKENISKEEERKKLQEEIVNSVKGCGNCSC 720 730 740 750 >>NP_001258627 (OMIM: 300135,301310) ATP-binding cassett (726 aa) initn: 4316 init1: 4316 opt: 4316 Z-score: 5156.9 bits: 964.8 E(85289): 0 Smith-Waterman score: 4629; 96.4% identity (96.4% similar) in 753 aa overlap (1-753:1-726) 10 20 30 40 50 60 pF1KE6 MALLAMHSWRWAAAAAAFEKRRHSAILIRPLVSVSGSGPQWRPHQLGALGTARAYQQIPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MALLAMHSWRWAAAAAAFEKRRHSAILIRPLVSVSGSGPQWRPHQLGALGTARAYQ---- 10 20 30 40 50 70 80 90 100 110 120 pF1KE6 SLKSITWQRLGKGNSGQFLDAAKALQVWPLIEKRTCWHGHAGGGLHTDPKEGLKDVDTRK ::::::::::::::::::::::::::::::::::::: NP_001 -----------------------ALQVWPLIEKRTCWHGHAGGGLHTDPKEGLKDVDTRK 60 70 80 90 130 140 150 160 170 180 pF1KE6 IIKAMLSYVWPKDRPDLRARVAISLGFLGGAKAMNIVVPFMFKYAVDSLNQMSGNMLNLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IIKAMLSYVWPKDRPDLRARVAISLGFLGGAKAMNIVVPFMFKYAVDSLNQMSGNMLNLS 100 110 120 130 140 150 190 200 210 220 230 240 pF1KE6 DAPNTVATMATAVLIGYGVSRAGAAFFNEVRNAVFGKVAQNSIRRIAKNVFLHLHNLDLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DAPNTVATMATAVLIGYGVSRAGAAFFNEVRNAVFGKVAQNSIRRIAKNVFLHLHNLDLG 160 170 180 190 200 210 250 260 270 280 290 300 pF1KE6 FHLSRQTGALSKAIDRGTRGISFVLSALVFNLLPIMFEVMLVSGVLYYKCGAQFALVTLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FHLSRQTGALSKAIDRGTRGISFVLSALVFNLLPIMFEVMLVSGVLYYKCGAQFALVTLG 220 230 240 250 260 270 310 320 330 340 350 360 pF1KE6 TLGTYTAFTVAVTRWRTRFRIEMNKADNDAGNAAIDSLLNYETVKYFNNERYEAQRYDGF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TLGTYTAFTVAVTRWRTRFRIEMNKADNDAGNAAIDSLLNYETVKYFNNERYEAQRYDGF 280 290 300 310 320 330 370 380 390 400 410 420 pF1KE6 LKTYETASLKSTSTLAMLNFGQSAIFSVGLTAIMVLASQGIVAGTLTVGDLVMVNGLLFQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LKTYETASLKSTSTLAMLNFGQSAIFSVGLTAIMVLASQGIVAGTLTVGDLVMVNGLLFQ 340 350 360 370 380 390 430 440 450 460 470 480 pF1KE6 LSLPLNFLGTVYRETRQALIDMNTLFTLLKVDTQIKDKVMASPLQITPQTATVAFDNVHF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LSLPLNFLGTVYRETRQALIDMNTLFTLLKVDTQIKDKVMASPLQITPQTATVAFDNVHF 400 410 420 430 440 450 490 500 510 520 530 540 pF1KE6 EYIEGQKVLSGISFEVPAGKKVAIVGGSGSGKSTIVRLLFRFYEPQKGSIYLAGQNIQDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EYIEGQKVLSGISFEVPAGKKVAIVGGSGSGKSTIVRLLFRFYEPQKGSIYLAGQNIQDV 460 470 480 490 500 510 550 560 570 580 590 600 pF1KE6 SLESLRRAVGVVPQDAVLFHNTIYYNLLYGNISASPEEVYAVAKLAGLHDAILRMPHGYD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SLESLRRAVGVVPQDAVLFHNTIYYNLLYGNISASPEEVYAVAKLAGLHDAILRMPHGYD 520 530 540 550 560 570 610 620 630 640 650 660 pF1KE6 TQVGERGLKLSGGEKQRVAIARAILKDPPVILYDEATSSLDSITEETILGAMKDVVKHRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TQVGERGLKLSGGEKQRVAIARAILKDPPVILYDEATSSLDSITEETILGAMKDVVKHRT 580 590 600 610 620 630 670 680 690 700 710 720 pF1KE6 SIFIAHRLSTVVDADEIIVLDQGKVAERGTHHGLLANPHSIYSEMWHTQSSRVQNHDNPK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SIFIAHRLSTVVDADEIIVLDQGKVAERGTHHGLLANPHSIYSEMWHTQSSRVQNHDNPK 640 650 660 670 680 690 730 740 750 pF1KE6 WEAKKENISKEEERKKLQEEIVNSVKGCGNCSC ::::::::::::::::::::::::::::::::: NP_001 WEAKKENISKEEERKKLQEEIVNSVKGCGNCSC 700 710 720 >>NP_001258626 (OMIM: 300135,301310) ATP-binding cassett (712 aa) initn: 4193 init1: 3825 opt: 3827 Z-score: 4572.4 bits: 856.7 E(85289): 0 Smith-Waterman score: 4501; 94.6% identity (94.6% similar) in 753 aa overlap (1-753:1-712) 10 20 30 40 50 60 pF1KE6 MALLAMHSWRWAAAAAAFEKRRHSAILIRPLVSVSGSGPQWRPHQLGALGTARAYQQIPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::: ::: NP_001 MALLAMHSWRWAAAAAAFEKRRHSAILIRPLVSVSGSGPQWRPHQLGALGTARAYQ-IPE 10 20 30 40 50 70 80 90 100 110 120 pF1KE6 SLKSITWQRLGKGNSGQFLDAAKALQVWPLIEKRTCWHGHAGGGLHTDPKEGLKDVDTRK :::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SLKSITWQRLGKGNSGQFLDAAKALQVWPLIEKRTCWHGHAGGGLHTDPKEG-------- 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE6 IIKAMLSYVWPKDRPDLRARVAISLGFLGGAKAMNIVVPFMFKYAVDSLNQMSGNMLNLS :::::::::::::::::::::::::::: NP_001 --------------------------------AMNIVVPFMFKYAVDSLNQMSGNMLNLS 120 130 190 200 210 220 230 240 pF1KE6 DAPNTVATMATAVLIGYGVSRAGAAFFNEVRNAVFGKVAQNSIRRIAKNVFLHLHNLDLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DAPNTVATMATAVLIGYGVSRAGAAFFNEVRNAVFGKVAQNSIRRIAKNVFLHLHNLDLG 140 150 160 170 180 190 250 260 270 280 290 300 pF1KE6 FHLSRQTGALSKAIDRGTRGISFVLSALVFNLLPIMFEVMLVSGVLYYKCGAQFALVTLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FHLSRQTGALSKAIDRGTRGISFVLSALVFNLLPIMFEVMLVSGVLYYKCGAQFALVTLG 200 210 220 230 240 250 310 320 330 340 350 360 pF1KE6 TLGTYTAFTVAVTRWRTRFRIEMNKADNDAGNAAIDSLLNYETVKYFNNERYEAQRYDGF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TLGTYTAFTVAVTRWRTRFRIEMNKADNDAGNAAIDSLLNYETVKYFNNERYEAQRYDGF 260 270 280 290 300 310 370 380 390 400 410 420 pF1KE6 LKTYETASLKSTSTLAMLNFGQSAIFSVGLTAIMVLASQGIVAGTLTVGDLVMVNGLLFQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LKTYETASLKSTSTLAMLNFGQSAIFSVGLTAIMVLASQGIVAGTLTVGDLVMVNGLLFQ 320 330 340 350 360 370 430 440 450 460 470 480 pF1KE6 LSLPLNFLGTVYRETRQALIDMNTLFTLLKVDTQIKDKVMASPLQITPQTATVAFDNVHF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LSLPLNFLGTVYRETRQALIDMNTLFTLLKVDTQIKDKVMASPLQITPQTATVAFDNVHF 380 390 400 410 420 430 490 500 510 520 530 540 pF1KE6 EYIEGQKVLSGISFEVPAGKKVAIVGGSGSGKSTIVRLLFRFYEPQKGSIYLAGQNIQDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EYIEGQKVLSGISFEVPAGKKVAIVGGSGSGKSTIVRLLFRFYEPQKGSIYLAGQNIQDV 440 450 460 470 480 490 550 560 570 580 590 600 pF1KE6 SLESLRRAVGVVPQDAVLFHNTIYYNLLYGNISASPEEVYAVAKLAGLHDAILRMPHGYD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SLESLRRAVGVVPQDAVLFHNTIYYNLLYGNISASPEEVYAVAKLAGLHDAILRMPHGYD 500 510 520 530 540 550 610 620 630 640 650 660 pF1KE6 TQVGERGLKLSGGEKQRVAIARAILKDPPVILYDEATSSLDSITEETILGAMKDVVKHRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TQVGERGLKLSGGEKQRVAIARAILKDPPVILYDEATSSLDSITEETILGAMKDVVKHRT 560 570 580 590 600 610 670 680 690 700 710 720 pF1KE6 SIFIAHRLSTVVDADEIIVLDQGKVAERGTHHGLLANPHSIYSEMWHTQSSRVQNHDNPK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SIFIAHRLSTVVDADEIIVLDQGKVAERGTHHGLLANPHSIYSEMWHTQSSRVQNHDNPK 620 630 640 650 660 670 730 740 750 pF1KE6 WEAKKENISKEEERKKLQEEIVNSVKGCGNCSC ::::::::::::::::::::::::::::::::: NP_001 WEAKKENISKEEERKKLQEEIVNSVKGCGNCSC 680 690 700 710 >>NP_001258628 (OMIM: 300135,301310) ATP-binding cassett (713 aa) initn: 3825 init1: 3825 opt: 3827 Z-score: 4572.4 bits: 856.7 E(85289): 0 Smith-Waterman score: 4520; 94.7% identity (94.7% similar) in 753 aa overlap (1-753:1-713) 10 20 30 40 50 60 pF1KE6 MALLAMHSWRWAAAAAAFEKRRHSAILIRPLVSVSGSGPQWRPHQLGALGTARAYQQIPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MALLAMHSWRWAAAAAAFEKRRHSAILIRPLVSVSGSGPQWRPHQLGALGTARAYQQIPE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 SLKSITWQRLGKGNSGQFLDAAKALQVWPLIEKRTCWHGHAGGGLHTDPKEGLKDVDTRK :::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SLKSITWQRLGKGNSGQFLDAAKALQVWPLIEKRTCWHGHAGGGLHTDPKEG-------- 70 80 90 100 110 130 140 150 160 170 180 pF1KE6 IIKAMLSYVWPKDRPDLRARVAISLGFLGGAKAMNIVVPFMFKYAVDSLNQMSGNMLNLS :::::::::::::::::::::::::::: NP_001 --------------------------------AMNIVVPFMFKYAVDSLNQMSGNMLNLS 120 130 140 190 200 210 220 230 240 pF1KE6 DAPNTVATMATAVLIGYGVSRAGAAFFNEVRNAVFGKVAQNSIRRIAKNVFLHLHNLDLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DAPNTVATMATAVLIGYGVSRAGAAFFNEVRNAVFGKVAQNSIRRIAKNVFLHLHNLDLG 150 160 170 180 190 200 250 260 270 280 290 300 pF1KE6 FHLSRQTGALSKAIDRGTRGISFVLSALVFNLLPIMFEVMLVSGVLYYKCGAQFALVTLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FHLSRQTGALSKAIDRGTRGISFVLSALVFNLLPIMFEVMLVSGVLYYKCGAQFALVTLG 210 220 230 240 250 260 310 320 330 340 350 360 pF1KE6 TLGTYTAFTVAVTRWRTRFRIEMNKADNDAGNAAIDSLLNYETVKYFNNERYEAQRYDGF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TLGTYTAFTVAVTRWRTRFRIEMNKADNDAGNAAIDSLLNYETVKYFNNERYEAQRYDGF 270 280 290 300 310 320 370 380 390 400 410 420 pF1KE6 LKTYETASLKSTSTLAMLNFGQSAIFSVGLTAIMVLASQGIVAGTLTVGDLVMVNGLLFQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LKTYETASLKSTSTLAMLNFGQSAIFSVGLTAIMVLASQGIVAGTLTVGDLVMVNGLLFQ 330 340 350 360 370 380 430 440 450 460 470 480 pF1KE6 LSLPLNFLGTVYRETRQALIDMNTLFTLLKVDTQIKDKVMASPLQITPQTATVAFDNVHF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LSLPLNFLGTVYRETRQALIDMNTLFTLLKVDTQIKDKVMASPLQITPQTATVAFDNVHF 390 400 410 420 430 440 490 500 510 520 530 540 pF1KE6 EYIEGQKVLSGISFEVPAGKKVAIVGGSGSGKSTIVRLLFRFYEPQKGSIYLAGQNIQDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EYIEGQKVLSGISFEVPAGKKVAIVGGSGSGKSTIVRLLFRFYEPQKGSIYLAGQNIQDV 450 460 470 480 490 500 550 560 570 580 590 600 pF1KE6 SLESLRRAVGVVPQDAVLFHNTIYYNLLYGNISASPEEVYAVAKLAGLHDAILRMPHGYD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SLESLRRAVGVVPQDAVLFHNTIYYNLLYGNISASPEEVYAVAKLAGLHDAILRMPHGYD 510 520 530 540 550 560 610 620 630 640 650 660 pF1KE6 TQVGERGLKLSGGEKQRVAIARAILKDPPVILYDEATSSLDSITEETILGAMKDVVKHRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TQVGERGLKLSGGEKQRVAIARAILKDPPVILYDEATSSLDSITEETILGAMKDVVKHRT 570 580 590 600 610 620 670 680 690 700 710 720 pF1KE6 SIFIAHRLSTVVDADEIIVLDQGKVAERGTHHGLLANPHSIYSEMWHTQSSRVQNHDNPK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SIFIAHRLSTVVDADEIIVLDQGKVAERGTHHGLLANPHSIYSEMWHTQSSRVQNHDNPK 630 640 650 660 670 680 730 740 750 pF1KE6 WEAKKENISKEEERKKLQEEIVNSVKGCGNCSC ::::::::::::::::::::::::::::::::: NP_001 WEAKKENISKEEERKKLQEEIVNSVKGCGNCSC 690 700 710 >>NP_005680 (OMIM: 111600,605452,609153,614497,615402) A (842 aa) initn: 1512 init1: 808 opt: 1585 Z-score: 1890.7 bits: 360.7 E(85289): 1.4e-98 Smith-Waterman score: 1585; 42.0% identity (73.4% similar) in 610 aa overlap (117-720:241-836) 90 100 110 120 130 140 pF1KE6 VWPLIEKRTCWHGHAGGGLHTDPKEGLKDVDTRKIIKAMLSYVWPKDRPDLRARVAISLG : . .. . .:.::. : :. : : :: NP_005 PQSYTLQVHEEDQDVERSQVRSAAQQSTWRDFGRKLRLLSGYLWPRGSPALQLVVLICLG 220 230 240 250 260 270 150 160 170 180 190 200 pF1KE6 FLGGAKAMNIVVPFMFKYAVDSLNQMSGNMLNLSDAP-NTVA-TMATAVLIGY--GVSRA ..: .:.:..::.... :. :.. :: :..: :... :.. . : . . NP_005 LMGLERALNVLVPIFYRNIVNLLTE---------KAPWNSLAWTVTSYVFLKFLQGGGTG 280 290 300 310 320 210 220 230 240 250 260 pF1KE6 GAAFFNEVRNAVFGKVAQNSIRRIAKNVFLHLHNLDLGFHLSRQTGALSKAIDRGTRGIS ...: ...:. .. .: : . ::. .: :::.:.: .::.:.:: . . :::: ... NP_005 STGFVSNLRTFLWIRVQQFTSRRVELLIFSHLHELSLRWHLGRRTGEVLRIADRGTSSVT 330 340 350 360 370 380 270 280 290 300 310 320 pF1KE6 FVLSALVFNLLPIMFEVMLVSGVLYYKC--GAQFALVTLGTLGTYTAFTVAVTRWRTRFR .:: ::::..: . .... :..:.. .: :.:... .. : ..:..::.:::.:: NP_005 GLLSYLVFNVIPTLADIII--GIIYFSMFFNAWFGLIVFLCMSLYLTLTIVVTEWRTKFR 390 400 410 420 430 330 340 350 360 370 380 pF1KE6 IEMNKADNDAGNAAIDSLLNYETVKYFNNERYEAQRYDGFLKTYETASLKSTSTLAMLNF :: .: . :.:::::.:::::.: : ::..:: . :. ::...:..:: NP_005 RAMNTQENATRARAVDSLLNFETVKYYNAESYEVERYREAIIKYQGLEWKSSASLVLLNQ 440 450 460 470 480 490 390 400 410 420 430 440 pF1KE6 GQSAIFSVGLTAIMVLASQGIVAGTLTVGDLVMVNGLLFQLSLPLNFLGTVYRETRQALI :. ....:: : .: . .. : ::: :. . ..:: .:::..:: :: . .: NP_005 TQNLVIGLGLLAGSLLCAYFVTEQKLQVGDYVLFGTYIIQLYMPLNWFGTYYRMIQTNFI 500 510 520 530 540 550 450 460 470 480 490 500 pF1KE6 DMNTLFTLLKVDTQIKDKVMASPLQITPQTATVAFDNVHFEYIEGQKVLSGISFEVPAGK ::...: ::: .:..:: :.::.. : . . :.:::: : .:...:. .:: : :. NP_005 DMENMFDLLKEETEVKDLPGAGPLRF--QKGRIEFENVHFSYADGRETLQDVSFTVMPGQ 560 570 580 590 600 610 510 520 530 540 550 560 pF1KE6 KVAIVGGSGSGKSTIVRLLFRFYEPQKGSIYLAGQNIQDVSLESLRRAVGVVPQDAVLFH .:.:: ::.:::::.:::::::. ..: : . ::.:..:. ::: .::::::.:::. NP_005 TLALVGPSGAGKSTILRLLFRFYDISSGCIRIDGQDISQVTQASLRSHIGVVPQDTVLFN 620 630 640 650 660 670 570 580 590 600 610 620 pF1KE6 NTIYYNLLYGNISASPEEVYAVAKLAGLHDAILRMPHGYDTQVGERGLKLSGGEKQRVAI .:: :. :: ..:. .:: :.:. ::.::::. .:.:: :::::::::::::::::::: NP_005 DTIADNIRYGRVTAGNDEVEAAAQAAGIHDAIMAFPEGYRTQVGERGLKLSGGEKQRVAI 680 690 700 710 720 730 630 640 650 660 670 680 pF1KE6 ARAILKDPPVILYDEATSSLDSITEETILGAMKDVVKHRTSIFIAHRLSTVVDADEIIVL ::.::: : .:: :::::.::. .:..: ... : .::.: .::::::::.::.:.:. NP_005 ARTILKAPGIILLDEATSALDTSNERAIQASLAKVCANRTTIVVAHRLSTVVNADQILVI 740 750 760 770 780 790 690 700 710 720 730 740 pF1KE6 DQGKVAERGTHHGLLANPHSIYSEMWHTQSSRVQNHDNPKWEAKKENISKEEERKKLQEE .: ..::: :..::. ..:..::. :... .. .. : NP_005 KDGCIVERGRHEALLSRG-GVYADMWQLQQGQEETSEDTKPQTMER 800 810 820 830 840 750 pF1KE6 IVNSVKGCGNCSC >>NP_036221 (OMIM: 605454) ATP-binding cassette sub-fami (738 aa) initn: 630 init1: 415 opt: 801 Z-score: 954.2 bits: 187.2 E(85289): 2.1e-46 Smith-Waterman score: 803; 29.5% identity (61.9% similar) in 599 aa overlap (123-710:158-734) 100 110 120 130 140 150 pF1KE6 KRTCWHGHAGGGLHTDPKEGLKDVDTRKIIKAMLSYVWPKDRPDLRARVAISLGFLGGAK . .:. ..:. : :.: ..::: .. NP_036 AGDEAWRRGPAAPPGDKGRLRPAAAGLPEARKLLGLAYPERR-----RLAAAVGFLTMSS 130 140 150 160 170 180 160 170 180 190 200 210 pF1KE6 AMNIVVPFMFKYAVDSLNQMSGNMLNLSDAPNTVATMATAVLIGYGVSRAGAAFFNEVRN .... .::.. .: . ... .. :: . . .::.. ::: : .: NP_036 VISMSAPFFLGKIIDVI--YTNPTVDYSDNLTRLCLGLSAVFL------CGAAA-NAIRV 190 200 210 220 230 220 230 240 250 260 270 pF1KE6 AVFGKVAQNSIRRIAKNVFLHLHNLDLGFHLSRQTGALSKAIDRGTRGISFVLSALVFNL .. .: . :. ..: . ...: . .:: : :.: . ... ... :: NP_036 YLMQTSGQRIVNRLRTSLFSSILRQEVAFFDKTRTGEL---INRLSSDTALLGRSVTENL 240 250 260 270 280 290 280 290 300 310 320 330 pF1KE6 LPIMFEVMLVS-GV-LYYKCGAQFALVTLGTLGTYTAFTVAVTRWRTRFRIEMNKADNDA . .: :. ... . ..: .:... . ..: :. .. . . .: NP_036 SDGLRAGAQASVGISMMFFVSPNLATFVLSVVPPVSIIAVIYGRYLRKLTKVTQDSLAQA 300 310 320 330 340 350 340 350 360 370 380 390 pF1KE6 GNAAIDSLLNYETVKYFNNERYEAQRYDGFLKTYETASLKSTSTLAMLNFGQSAIFSVGL . : . . : .::. :..: : ..: . :. .. .: ..: .: .. .: .: NP_036 TQLAEERIGNVRTVRAFGKEMTEIEKYAS--KVDHVMQLARKEAFARAGFFGATGLSGNL 360 370 380 390 400 400 410 420 430 440 pF1KE6 TAIMVLASQGIVAGT--LTVGDLVMVNGLLFQLSLPLNFLGTVYRETRQALIDMNTLFTL .. :: . :.. :. .:::.: : ... .. :.. : : ..: . :. : NP_036 IVLSVLYKGGLLMGSAHMTVGELSSFLMYAFWVGISIGGLSSFYSELMKGLGAGGRLWEL 410 420 430 440 450 460 450 460 470 480 490 500 pF1KE6 LKVDTQI--KDKVMASPLQITPQTATVAFDNVHFEYIEGQKV--LSGISFEVPAGKKVAI :. . .. .. :. . . . : : . : :::: : .: .. .:. .:.:. .:. NP_036 LEREPKLPFNEGVILN--EKSFQGA-LEFKNVHFAYPARPEVPIFQDFSLSIPSGSVTAL 470 480 490 500 510 520 510 520 530 540 550 560 pF1KE6 VGGSGSGKSTIVRLLFRFYEPQKGSIYLAGQNIQDVSLESLRRAVGVVPQDAVLFHNTIY :: :::::::.. ::.:.:.: .:.: : :..:.... :: .:.: :. .:: .: NP_036 VGPSGSGKSTVLSLLLRLYDPASGTISLDGHDIRQLNPVWLRSKIGTVSQEPILFSCSIA 530 540 550 560 570 580 570 580 590 600 610 620 pF1KE6 YNLLYGN---ISASPEEVYAVAKLAGLHDAILRMPHGYDTQVGERGLKLSGGEKQRVAIA :. :: :.. ::. ::..:. : .:.:..: :::.:. ::::.:::.::: NP_036 ENIAYGADDPSSVTAEEIQRVAEVANAVAFIRNFPQGFNTVVGEKGVLLSGGQKQRIAIA 590 600 610 620 630 640 630 640 650 660 670 680 pF1KE6 RAILKDPPVILYDEATSSLDSITEETILGAMKDVVKHRTSIFIAHRLSTVVDADEIIVLD ::.::.: ..: :::::.::. .: . :. .. :: . :::::::. .:. . ::: NP_036 RALLKNPKILLLDEATSALDAENEYLVQEALDRLMDGRTVLVIAHRLSTIKNANMVAVLD 650 660 670 680 690 700 690 700 710 720 730 740 pF1KE6 QGKVAERGTHHGLLANPHSIYSEMWHTQSSRVQNHDNPKWEAKKENISKEEERKKLQEEI :::..: : :. ::..:..:: .. . :: NP_036 QGKITEYGKHEELLSKPNGIYRKLMNKQSFISA 710 720 730 >>XP_011542437 (OMIM: 605454) PREDICTED: ATP-binding cas (559 aa) initn: 660 init1: 415 opt: 766 Z-score: 914.2 bits: 179.4 E(85289): 3.5e-44 Smith-Waterman score: 766; 29.6% identity (62.0% similar) in 571 aa overlap (151-710:2-555) 130 140 150 160 170 180 pF1KE6 IIKAMLSYVWPKDRPDLRARVAISLGFLGGAKAMNIVVPFMFKYAVDSLNQMSGNMLNLS ...... .::.. .: . ... .. : XP_011 MSSVISMSAPFFLGKIIDVI--YTNPTVDYS 10 20 190 200 210 220 230 240 pF1KE6 DAPNTVATMATAVLIGYGVSRAGAAFFNEVRNAVFGKVAQNSIRRIAKNVFLHLHNLDLG : . . .::.. ::: : .: .. .: . :. ..: . ... XP_011 DNLTRLCLGLSAVFL------CGAAA-NAIRVYLMQTSGQRIVNRLRTSLFSSILRQEVA 30 40 50 60 70 80 250 260 270 280 290 pF1KE6 FHLSRQTGALSKAIDRGTRGISFVLSALVFNLLPIMFEVMLVS-GV-LYYKCGAQFALVT : . .:: : :.: . ... ... :: . .: :. ... . ..: . XP_011 FFDKTRTGEL---INRLSSDTALLGRSVTENLSDGLRAGAQASVGISMMFFVSPNLATFV 90 100 110 120 130 300 310 320 330 340 350 pF1KE6 LGTLGTYTAFTVAVTRWRTRFRIEMNKADNDAGNAAIDSLLNYETVKYFNNERYEAQRYD :... . ..: :. .. . . .: . : . . : .::. :..: : ..: XP_011 LSVVPPVSIIAVIYGRYLRKLTKVTQDSLAQATQLAEERIGNVRTVRAFGKEMTEIEKYA 140 150 160 170 180 190 360 370 380 390 400 410 pF1KE6 GFLKTYETASLKSTSTLAMLNFGQSAIFSVGLTAIMVLASQGIVAGT--LTVGDLVMVNG . :. .. .: ..: .: .. .: .: .. :: . :.. :. .:::.: XP_011 S--KVDHVMQLARKEAFARAGFFGATGLSGNLIVLSVLYKGGLLMGSAHMTVGELSSFLM 200 210 220 230 240 250 420 430 440 450 460 470 pF1KE6 LLFQLSLPLNFLGTVYRETRQALIDMNTLFTLLKVDTQI--KDKVMASPLQITPQTATVA : ... .. :.. : : ..: . :. ::. . .. .. :. . . . : : . XP_011 YAFWVGISIGGLSSFYSELMKGLGAGGRLWELLEREPKLPFNEGVILN--EKSFQGA-LE 260 270 280 290 300 310 480 490 500 510 520 530 pF1KE6 FDNVHFEYIEGQKV--LSGISFEVPAGKKVAIVGGSGSGKSTIVRLLFRFYEPQKGSIYL : :::: : .: .. .:. .:.:. .:.:: :::::::.. ::.:.:.: .:.: : XP_011 FKNVHFAYPARPEVPIFQDFSLSIPSGSVTALVGPSGSGKSTVLSLLLRLYDPASGTISL 320 330 340 350 360 370 540 550 560 570 580 pF1KE6 AGQNIQDVSLESLRRAVGVVPQDAVLFHNTIYYNLLYGN---ISASPEEVYAVAKLAGLH :..:.... :: .:.: :. .:: .: :. :: :.. ::. ::..:. XP_011 DGHDIRQLNPVWLRSKIGTVSQEPILFSCSIAENIAYGADDPSSVTAEEIQRVAEVANAV 380 390 400 410 420 430 590 600 610 620 630 640 pF1KE6 DAILRMPHGYDTQVGERGLKLSGGEKQRVAIARAILKDPPVILYDEATSSLDSITEETIL : .:.:..: :::.:. ::::.:::.:::::.::.: ..: :::::.::. .: . XP_011 AFIRNFPQGFNTVVGEKGVLLSGGQKQRIAIARALLKNPKILLLDEATSALDAENEYLVQ 440 450 460 470 480 490 650 660 670 680 690 700 pF1KE6 GAMKDVVKHRTSIFIAHRLSTVVDADEIIVLDQGKVAERGTHHGLLANPHSIYSEMWHTQ :. .. :: . :::::::. .:. . ::::::..: : :. ::..:..:: .. . : XP_011 EALDRLMDGRTVLVIAHRLSTIKNANMVAVLDQGKITEYGKHEELLSKPNGIYRKLMNKQ 500 510 520 530 540 550 710 720 730 740 750 pF1KE6 SSRVQNHDNPKWEAKKENISKEEERKKLQEEIVNSVKGCGNCSC : XP_011 SFISA >>NP_001157413 (OMIM: 611785) ATP-binding cassette sub-f (1257 aa) initn: 669 init1: 599 opt: 765 Z-score: 907.7 bits: 179.4 E(85289): 8.1e-44 Smith-Waterman score: 765; 30.9% identity (60.8% similar) in 576 aa overlap (184-746:100-655) 160 170 180 190 200 210 pF1KE6 MNIVVPFMFKYAVDSLNQMSGNMLNLSDAPNTVATMATAVLIGYGVSRAGAAFFNEVRNA : :. : .: ::. : .:. .. . NP_001 GEMSDNLISGCLVQTNTTNYQNCTQSQEKLNEDMTLLTLYYVGIGVA---ALIFGYIQIS 70 80 90 100 110 120 220 230 240 250 260 pF1KE6 VFGKVAQNSIRRIAKNVFLHLHNLDLGFHLSRQTGAL----SKAIDRGTRGISFVLSALV .. .: . .:: :. : . :.:. : . : : . ::. . ::. . ::. NP_001 LWIITAARQTKRIRKQFFHSVLAQDIGWFDSCDIGELNTRMTDDIDKISDGIGDKI-ALL 130 140 150 160 170 180 270 280 290 300 310 320 pF1KE6 FNLLPIMFEVMLVSGVLYYKCGAQFALVTLGTLGTYTAFTVAVTRWRTRFRIEMNKADND :. . : . :. :.. : ...::::.: : ..: .: . . .: . NP_001 FQNMST-FSIGLAVGLVK---GWKLTLVTLSTSPLIMASAAACSRMVISLTSKELSAYSK 190 200 210 220 230 240 330 340 350 360 370 380 pF1KE6 AGNAAIDSLLNYETVKYFNNERYEAQRYDGFLKTYETASLKSTSTLAMLNFGQSAIFSVG :: .: . : . .:: : .. : ::: :: . ..: : . ...: .: : NP_001 AGAVAEEVLSSIRTVIAFRAQEKELQRYTQNLKDAKDFGIKRT-IASKVSLGAVYFFMNG 250 260 270 280 290 300 390 400 410 420 430 440 pF1KE6 LTAIMV-LASQGIVAGT--LTVGDLVMVNGLLFQLSLPLNFLGTVYRETRQALIDMNTLF .. ... :. : :.: .. : .:.. .:.. . . : .. : NP_001 TYGLAFWYGTSLILNGEPGYTIGTVLAV---FFSVIHSSYCIGAAVPHFETFAIARGAAF 310 320 330 340 350 450 460 470 480 490 500 pF1KE6 TLLKVDTQIKDKVMASPLQITPQT--ATVAFDNVHFEYIE--GQKVLSGISFEVPAGKKV ...: . . : :.. .:: : :: :.: . :.:.:..... .:. : NP_001 HIFQVIDKKPSIDNFSTAGYKPESIEGTVEFKNVSFNYPSRPSIKILKGLNLRIKSGETV 360 370 380 390 400 410 510 520 530 540 550 560 pF1KE6 AIVGGSGSGKSTIVRLLFRFYEPQKGSIYLAGQNIQDVSLESLRRAVGVVPQDAVLFHNT :.:: .::::::.:.:: :.:.:. : :.. ..:. .... : .::: :. ::: .: NP_001 ALVGLNGSGKSTVVQLLQRLYDPDDGFIMVDENDIRALNVRHYRDHIGVVSQEPVLFGTT 420 430 440 450 460 470 570 580 590 600 610 620 pF1KE6 IYYNLLYGNISASPEEVYAVAKLAGLHDAILRMPHGYDTQVGERGLKLSGGEKQRVAIAR : :. :: ... ::. .:. :. .: :...:. ..: :::.: ..:::.:::.:::: NP_001 ISNNIKYGRDDVTDEEMERAAREANAYDFIMEFPNKFNTLVGEKGAQMSGGQKQRIAIAR 480 490 500 510 520 530 630 640 650 660 670 680 pF1KE6 AILKDPPVILYDEATSSLDSITEETILGAMKDVVKHRTSIFIAHRLSTVVDADEIIVLDQ :....: ... :::::.::: .. .. .:.. . : ::.: .::::::. .:: :..: . NP_001 ALVRNPKILILDEATSALDSESKSAVQAALEKASKGRTTIVVAHRLSTIRSADLIVTLKD 540 550 560 570 580 590 690 700 710 720 730 740 pF1KE6 GKVAERGTHHGLLANPHSIYSEMWHTQSSRVQNHDNPKWEAKKENISKEEERK--KLQEE : .::.:.: :.:. : : :...: : . . :... ::: .: . NP_001 GMLAEKGAHAELMAKRGLYY--------SLVMSQDIKKADEQMESMTYSTERKTNSLPLH 600 610 620 630 640 750 pF1KE6 IVNSVKGCGNCSC :.:.: NP_001 SVKSIKSDFIDKAEESTQSKEISLPEVSLLKILKLNKPEWPFVVLGTLASVLNGTVHPVF 650 660 670 680 690 700 >-- initn: 544 init1: 319 opt: 668 Z-score: 791.7 bits: 157.9 E(85289): 2.3e-37 Smith-Waterman score: 668; 28.1% identity (59.2% similar) in 613 aa overlap (107-710:666-1255) 80 90 100 110 120 130 pF1KE6 QFLDAAKALQVWPLIEKRTCWHGHAGGGLHTDPKE-GLKDVDTRKIIKAMLSYVWPKDRP :. :: .: .:. ::.: . . :: NP_001 TYSTERKTNSLPLHSVKSIKSDFIDKAEESTQSKEISLPEVSLLKILK-LNKPEWP---- 640 650 660 670 680 690 140 150 160 170 180 190 pF1KE6 DLRARVAISLGFLGGAKAMNIVVPFMFKYAVDSLNQMSGNMLNLSDAPNTVATMATAVLI . :: : :...: .: .:. .. : :: : . . . : . . ... NP_001 ------FVVLGTL--ASVLNGTVHPVFSIIFAKIITMFGN--NDKTTLKHDAEIYSMIFV 700 710 720 730 740 200 210 220 230 240 250 pF1KE6 GYGVSRAGAAFFNEVRNAVFGKVAQNSIRRIAKNVFLHLHNLDLGFHLSRQ--TGALSKA :: ...: ... .:.... :. . .: . :... .. ::.:. NP_001 ILGVI-CFVSYF--MQGLFYGRAGEILTMRLRHLAFKAMLYQDIAWFDEKENSTGGLTTI 750 760 770 780 790 260 270 280 290 300 310 pF1KE6 IDRGTRGISFVLSALVFNLLPIMFEVMLVSGVLYYKCGAQFALVTLGTLGTYTAFTVAVT . :. . .. . ..: : .: .. . : ..... :. . .. . : NP_001 LAIDIAQIQGATGSRI-GVLTQNATNMGLSVIISFIYGWEMTFLILSIAPVLAVTGMIET 800 810 820 830 840 850 320 330 340 350 360 370 pF1KE6 RWRTRFRIEMNKADNDAGNAAIDSLLNYETVKYFNNERYEAQRYDGFLKTYETASLKSTS : : . .. . ::. : ..: : .:. .. :. : :. .:.: . . :... NP_001 AAMTGFANKDKQELKHAGKIATEALENIRTIVSLTREKAFEQMYEEMLQTQHRNTSKKAQ 860 870 880 890 900 910 380 390 400 410 420 430 pF1KE6 TLAMLNFGQSAIFSVGLTAIMVLASQGIVAGTLTVGDLVMVNGLLFQLSLPLNFLGTVYR .. . :.. . .: . ... : :: .: . .: . .. .. .. NP_001 IIGSCYAFSHAFIYFAYAAGFRFGAYLIQAGRMTPEGMFIVFTAIAYGAMAIGETLVLAP 920 930 940 950 960 970 440 450 460 470 480 pF1KE6 ETRQALIDMNTLFTLLKVDTQIKDKVMASPLQITPQT--ATVAFDNVHFEYIEGQKV--L : .: ::.::. .: .. : :.: ... : .: : : : : NP_001 EYSKAKSGAAHLFALLEKKPNIDSR---SQEGKKPDTCEGNLEFREVSFFYPCRPDVFIL 980 990 1000 1010 1020 1030 490 500 510 520 530 540 pF1KE6 SGISFEVPAGKKVAIVGGSGSGKSTIVRLLFRFYEPQKGSIYLAGQNIQDVSLESLRRAV :.:. . :: ::.::.:: :::: :.:: :.:.: .:.. . : . ...... :: . NP_001 RGLSLSIERGKTVAFVGSSGCGKSTSVQLLQRLYDPVQGQVLFDGVDAKELNVQWLRSQI 1040 1050 1060 1070 1080 1090 550 560 570 580 590 600 pF1KE6 GVVPQDAVLFHNTIYYNLLYGNIS-ASP-EEVYAVAKLAGLHDAILRMPHGYDTQVGERG ..:::. :::. .: :. ::. : . : .:. .:. :..:. : .:. :.:::: .: NP_001 AIVPQEPVLFNCSIAENIAYGDNSRVVPLDEIKEAANAANIHSFIEGLPEKYNTQVGLKG 1100 1110 1120 1130 1140 1150 610 620 630 640 650 660 pF1KE6 LKLSGGEKQRVAIARAILKDPPVILYDEATSSLDSITEETILGAMKDVVKHRTSIFIAHR .::::.:::.:::::.:. : ..: :::::.::. .:... :. . :: . ..:: NP_001 AQLSGGQKQRLAIARALLQKPKILLLDEATSALDNDSEKVVQHALDKARTGRTCLVVTHR 1160 1170 1180 1190 1200 1210 670 680 690 700 710 720 pF1KE6 LSTVVDADEIIVLDQGKVAERGTHHGLLANPHSIYSEMWHTQSSRVQNHDNPKWEAKKEN ::.. .:: :.:: .::. :.:::. :: : ..:: .. ..:: NP_001 LSAIQNADLIVVLHNGKIKEQGTHQELLRN-RDIYFKLVNAQSVQ 1220 1230 1240 1250 730 740 750 pF1KE6 ISKEEERKKLQEEIVNSVKGCGNCSC >>XP_011536398 (OMIM: 605453) PREDICTED: ATP-binding cas (766 aa) initn: 597 init1: 564 opt: 754 Z-score: 897.8 bits: 176.8 E(85289): 2.9e-43 Smith-Waterman score: 776; 29.8% identity (60.7% similar) in 593 aa overlap (122-709:174-741) 100 110 120 130 140 150 pF1KE6 EKRTCWHGHAGGGLHTDPKEGLKDVDTRKIIKAMLSYVWPKDRPDLRARVAISLGFLGGA .. .:::. .::. :: :. :: : XP_011 TQALEPGAATEAEGFPGSGRPPPEQASGATLQKLLSYT----KPDVAFLVAASF-FLIVA 150 160 170 180 190 160 170 180 190 200 210 pF1KE6 KAMNIVVPFMFKYAVDSLNQMSGNMLNLSDAPNTVATMATAVLIGYGVSRAGAAFFNEVR . .:.. :.:.. .. .: ..: : : .: :..: .: XP_011 ALGETFLPYYTGRAIDGIV-IQKSMDQFSTAVVIVCLLAI-----------GSSFAAGIR 200 210 220 230 240 220 230 240 250 260 270 pF1KE6 NAVFGKVAQNSIRRIAKNVFLHLHNLDLGFHLSRQTGALSKAIDRGTRGISFVLSALVFN ...: . :. . .: : . . .: .:: : :.: : ..: . . : XP_011 GGIFTLIFARLNIRLRNCLFRSLVSQETSFFDENRTGDL---ISRLTSDTTMVSDLVSQN 250 260 270 280 290 300 280 290 300 310 320 pF1KE6 LLPIMFEVMLVSGVL--YYKCGAQFALVTLGTLGTYTAFTVAVTRWRTRFRIEMNKADND . .. ... :.::. ... . :..:::. . . .. :. :...: XP_011 INVFLRNTVKVTGVVVFMFSLSWQLSLVTFMGFPIIMMVSNIYGKYYKRLSKEVQNALAR 310 320 330 340 350 360 330 340 350 360 370 380 pF1KE6 AGNAAIDSLLNYETVKYFNNERYEAQRYDGFLKTYETASLKSTSTLAMLNFGQSAIFSVG :.:.: ... ..::. : ::. ::. : :. . : ... . .:.. . : XP_011 ASNTAEETISAMKTVRSFANEEEEAEVYLRKLQQVYKLNRKEAAAYMYYVWGSGLTLLVV 370 380 390 400 410 420 390 400 410 420 430 440 pF1KE6 LTAIMVLASQGIVAGTLTVGDLVMVNGLLFQLSLPLNFLGTVYRETRQALIDMNTLFTLL ..:. ... ...: .: :.:. : :. .. .:.:: :.. . .: .. XP_011 QVSILYYGGHLVISGQMTSGNLIAFIIYEFVLGDCMESVGSVYSGLMQGVGAAEKVFEFI 430 440 450 460 470 480 450 460 470 480 490 500 pF1KE6 -KVDTQIKDKVMASPLQITPQTATVAFDNVHFEYIE--GQKVLSGISFEVPAGKKVAIVG . :...: .: : .. . : :.:: : : .::...:: . :: .:.:: XP_011 DRQPTMVHDGSLA-PDHLEGR---VDFENVTFTYRTRPHTQVLQNVSFSLSPGKVTALVG 490 500 510 520 530 510 520 530 540 550 560 pF1KE6 GSGSGKSTIVRLLFRFYEPQKGSIYLAGQNIQDVSLESLRRAVGVVPQDAVLFHNTIYYN ::::::. : .: :: . : . : :. :. . . :.:....: :. ::: .: : XP_011 PSGSGKSSCVNILENFYPLEGGRVLLDGKPISAYDHKYLHRVISLVSQEPVLFARSITDN 540 550 560 570 580 590 570 580 590 600 610 620 pF1KE6 LLYGNISASPEEVYAVAKLAGLHDAILRMPHGYDTQVGERGLKLSGGEKQRVAIARAILK . :: .. : : .:. :. : :... ::.:..::.: .::::.:::::.:::... XP_011 ISYGLPTVPFEMVVEAAQKANAHGFIMELQDGYSTETGEKGAQLSGGQKQRVAMARALVR 600 610 620 630 640 650 630 640 650 660 670 680 pF1KE6 DPPVILYDEATSSLDSITEETILGAMKDVVKHRTSIFIAHRLSTVVDADEIIVLDQGKVA .:::.. :::::.::. .: : :.. ....: ..:::::::: : :.:::.:.:. XP_011 NPPVLILDEATSALDAESEYLIQQAIHGNLQKHTVLIIAHRLSTVEHAHLIVVLDKGRVV 660 670 680 690 700 710 690 700 710 720 730 740 pF1KE6 ERGTHHGLLANPHSIYSEMWHTQSSRVQNHDNPKWEAKKENISKEEERKKLQEEIVNSVK ..:::. :::. ..:... . : XP_011 QQGTHQQLLAQG-GLYAKLVQRQMLGLQPAADFTAGHNEPVANGSHKA 720 730 740 750 760 753 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Nov 8 15:41:49 2016 done: Tue Nov 8 15:41:50 2016 Total Scan time: 8.220 Total Display time: 0.220 Function used was FASTA [36.3.4 Apr, 2011]