FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE3669, 463 aa 1>>>pF1KE3669 463 - 463 aa - 463 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.3929+/-0.00041; mu= 17.7596+/- 0.025 mean_var=74.5962+/-14.885, 0's: 0 Z-trim(112.2): 56 B-trim: 219 in 1/53 Lambda= 0.148496 statistics sampled from 20979 (21035) to 20979 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.624), E-opt: 0.2 (0.247), width: 16 Scan time: 7.010 The best scores are: opt bits E(85289) NP_001949 (OMIM: 602959,616393,616409) elongation ( 463) 3062 665.7 7.6e-191 NP_001393 (OMIM: 130590) elongation factor 1-alpha ( 462) 2858 621.9 1.1e-177 XP_011533816 (OMIM: 130590) PREDICTED: elongation ( 462) 2858 621.9 1.1e-177 NP_001138630 (OMIM: 612450) HBS1-like protein isof ( 642) 739 168.1 6.4e-41 NP_006611 (OMIM: 612450) HBS1-like protein isoform ( 684) 739 168.1 6.7e-41 NP_001123479 (OMIM: 139259) eukaryotic peptide cha ( 499) 704 160.5 9.5e-39 NP_001123478 (OMIM: 139259) eukaryotic peptide cha ( 636) 704 160.6 1.2e-38 NP_002085 (OMIM: 139259) eukaryotic peptide chain ( 637) 704 160.6 1.2e-38 NP_060564 (OMIM: 300418) eukaryotic peptide chain ( 628) 688 157.1 1.2e-37 XP_011544230 (OMIM: 602389,610678) PREDICTED: elon ( 427) 267 66.8 1.3e-10 NP_003312 (OMIM: 602389,610678) elongation factor ( 455) 267 66.9 1.3e-10 XP_016879108 (OMIM: 602389,610678) PREDICTED: elon ( 455) 267 66.9 1.3e-10 XP_016884592 (OMIM: 602245) PREDICTED: GTP-binding ( 614) 250 63.3 2.1e-09 NP_004277 (OMIM: 602245) GTP-binding protein 1 [Ho ( 669) 250 63.3 2.3e-09 XP_016884589 (OMIM: 602245) PREDICTED: GTP-binding ( 726) 250 63.4 2.4e-09 XP_016884591 (OMIM: 602245) PREDICTED: GTP-binding ( 622) 247 62.7 3.4e-09 XP_016884590 (OMIM: 602245) PREDICTED: GTP-binding ( 684) 247 62.7 3.6e-09 XP_011528839 (OMIM: 602245) PREDICTED: GTP-binding ( 703) 247 62.7 3.7e-09 XP_016884588 (OMIM: 602245) PREDICTED: GTP-binding ( 734) 247 62.7 3.8e-09 NP_001273145 (OMIM: 607434) GTP-binding protein 2 ( 514) 217 56.2 2.5e-07 NP_061969 (OMIM: 607434) GTP-binding protein 2 iso ( 602) 217 56.2 2.8e-07 XP_016862469 (OMIM: 607695) PREDICTED: selenocyste ( 491) 183 48.9 3.7e-05 XP_016862468 (OMIM: 607695) PREDICTED: selenocyste ( 525) 183 48.9 3.9e-05 XP_016862467 (OMIM: 607695) PREDICTED: selenocyste ( 536) 183 48.9 4e-05 XP_016862466 (OMIM: 607695) PREDICTED: selenocyste ( 553) 183 48.9 4.1e-05 XP_016862465 (OMIM: 607695) PREDICTED: selenocyste ( 571) 183 48.9 4.2e-05 XP_016862464 (OMIM: 607695) PREDICTED: selenocyste ( 575) 183 48.9 4.2e-05 NP_068756 (OMIM: 607695) selenocysteine-specific e ( 596) 183 48.9 4.3e-05 XP_016866465 (OMIM: 607434) PREDICTED: GTP-binding ( 493) 175 47.2 0.00012 NP_001406 (OMIM: 300161,300987) eukaryotic transla ( 472) 158 43.5 0.0015 XP_006713858 (OMIM: 606639,609060) PREDICTED: elon ( 712) 159 43.9 0.0018 NP_001295095 (OMIM: 606639,609060) elongation fact ( 591) 147 41.2 0.0091 >>NP_001949 (OMIM: 602959,616393,616409) elongation fact (463 aa) initn: 3062 init1: 3062 opt: 3062 Z-score: 3547.3 bits: 665.7 E(85289): 7.6e-191 Smith-Waterman score: 3062; 100.0% identity (100.0% similar) in 463 aa overlap (1-463:1-463) 10 20 30 40 50 60 pF1KE3 MGKEKTHINIVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEKEAAEMGKGSFKYAWVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MGKEKTHINIVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEKEAAEMGKGSFKYAWVL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 DKLKAERERGITIDISLWKFETTKYYITIIDAPGHRDFIKNMITGTSQADCAVLIVAAGV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DKLKAERERGITIDISLWKFETTKYYITIIDAPGHRDFIKNMITGTSQADCAVLIVAAGV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 GEFEAGISKNGQTREHALLAYTLGVKQLIVGVNKMDSTEPAYSEKRYDEIVKEVSAYIKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GEFEAGISKNGQTREHALLAYTLGVKQLIVGVNKMDSTEPAYSEKRYDEIVKEVSAYIKK 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 IGYNPATVPFVPISGWHGDNMLEPSPNMPWFKGWKVERKEGNASGVSLLEALDTILPPTR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IGYNPATVPFVPISGWHGDNMLEPSPNMPWFKGWKVERKEGNASGVSLLEALDTILPPTR 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 PTDKPLRLPLQDVYKIGGIGTVPVGRVETGILRPGMVVTFAPVNITTEVKSVEMHHEALS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PTDKPLRLPLQDVYKIGGIGTVPVGRVETGILRPGMVVTFAPVNITTEVKSVEMHHEALS 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE3 EALPGDNVGFNVKNVSVKDIRRGNVCGDSKSDPPQEAAQFTSQVIILNHPGQISAGYSPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EALPGDNVGFNVKNVSVKDIRRGNVCGDSKSDPPQEAAQFTSQVIILNHPGQISAGYSPV 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE3 IDCHTAHIACKFAELKEKIDRRSGKKLEDNPKSLKSGDAAIVEMVPGKPMCVESFSQYPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IDCHTAHIACKFAELKEKIDRRSGKKLEDNPKSLKSGDAAIVEMVPGKPMCVESFSQYPP 370 380 390 400 410 420 430 440 450 460 pF1KE3 LGRFAVRDMRQTVAVGVIKNVEKKSGGAGKVTKSAQKAQKAGK ::::::::::::::::::::::::::::::::::::::::::: NP_001 LGRFAVRDMRQTVAVGVIKNVEKKSGGAGKVTKSAQKAQKAGK 430 440 450 460 >>NP_001393 (OMIM: 130590) elongation factor 1-alpha 1 [ (462 aa) initn: 2858 init1: 2858 opt: 2858 Z-score: 3311.1 bits: 621.9 E(85289): 1.1e-177 Smith-Waterman score: 2858; 92.6% identity (97.8% similar) in 461 aa overlap (1-461:1-461) 10 20 30 40 50 60 pF1KE3 MGKEKTHINIVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEKEAAEMGKGSFKYAWVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MGKEKTHINIVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEKEAAEMGKGSFKYAWVL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 DKLKAERERGITIDISLWKFETTKYYITIIDAPGHRDFIKNMITGTSQADCAVLIVAAGV ::::::::::::::::::::::.:::.::::::::::::::::::::::::::::::::: NP_001 DKLKAERERGITIDISLWKFETSKYYVTIIDAPGHRDFIKNMITGTSQADCAVLIVAAGV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 GEFEAGISKNGQTREHALLAYTLGVKQLIVGVNKMDSTEPAYSEKRYDEIVKEVSAYIKK :::::::::::::::::::::::::::::::::::::::: ::.:::.:::::::.:::: NP_001 GEFEAGISKNGQTREHALLAYTLGVKQLIVGVNKMDSTEPPYSQKRYEEIVKEVSTYIKK 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 IGYNPATVPFVPISGWHGDNMLEPSPNMPWFKGWKVERKEGNASGVSLLEALDTILPPTR ::::: :: :::::::.:::::::: :::::::::: ::.:::::..:::::: :::::: NP_001 IGYNPDTVAFVPISGWNGDNMLEPSANMPWFKGWKVTRKDGNASGTTLLEALDCILPPTR 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 PTDKPLRLPLQDVYKIGGIGTVPVGRVETGILRPGMVVTFAPVNITTEVKSVEMHHEALS ::::::::::::::::::::::::::::::.:.:::::::::::.::::::::::::::: NP_001 PTDKPLRLPLQDVYKIGGIGTVPVGRVETGVLKPGMVVTFAPVNVTTEVKSVEMHHEALS 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE3 EALPGDNVGFNVKNVSVKDIRRGNVCGDSKSDPPQEAAQFTSQVIILNHPGQISAGYSPV :::::::::::::::::::.::::: ::::.:::.::: ::.:::::::::::::::.:: NP_001 EALPGDNVGFNVKNVSVKDVRRGNVAGDSKNDPPMEAAGFTAQVIILNHPGQISAGYAPV 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE3 IDCHTAHIACKFAELKEKIDRRSGKKLEDNPKSLKSGDAAIVEMVPGKPMCVESFSQYPP .::::::::::::::::::::::::::::.:: :::::::::.:::::::::::::.::: NP_001 LDCHTAHIACKFAELKEKIDRRSGKKLEDGPKFLKSGDAAIVDMVPGKPMCVESFSDYPP 370 380 390 400 410 420 430 440 450 460 pF1KE3 LGRFAVRDMRQTVAVGVIKNVEKKSGGAGKVTKSAQKAQKAGK ::::::::::::::::::: :.::..::::::::::::::: NP_001 LGRFAVRDMRQTVAVGVIKAVDKKAAGAGKVTKSAQKAQKAK 430 440 450 460 >>XP_011533816 (OMIM: 130590) PREDICTED: elongation fact (462 aa) initn: 2858 init1: 2858 opt: 2858 Z-score: 3311.1 bits: 621.9 E(85289): 1.1e-177 Smith-Waterman score: 2858; 92.6% identity (97.8% similar) in 461 aa overlap (1-461:1-461) 10 20 30 40 50 60 pF1KE3 MGKEKTHINIVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEKEAAEMGKGSFKYAWVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MGKEKTHINIVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEKEAAEMGKGSFKYAWVL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 DKLKAERERGITIDISLWKFETTKYYITIIDAPGHRDFIKNMITGTSQADCAVLIVAAGV ::::::::::::::::::::::.:::.::::::::::::::::::::::::::::::::: XP_011 DKLKAERERGITIDISLWKFETSKYYVTIIDAPGHRDFIKNMITGTSQADCAVLIVAAGV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 GEFEAGISKNGQTREHALLAYTLGVKQLIVGVNKMDSTEPAYSEKRYDEIVKEVSAYIKK :::::::::::::::::::::::::::::::::::::::: ::.:::.:::::::.:::: XP_011 GEFEAGISKNGQTREHALLAYTLGVKQLIVGVNKMDSTEPPYSQKRYEEIVKEVSTYIKK 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 IGYNPATVPFVPISGWHGDNMLEPSPNMPWFKGWKVERKEGNASGVSLLEALDTILPPTR ::::: :: :::::::.:::::::: :::::::::: ::.:::::..:::::: :::::: XP_011 IGYNPDTVAFVPISGWNGDNMLEPSANMPWFKGWKVTRKDGNASGTTLLEALDCILPPTR 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 PTDKPLRLPLQDVYKIGGIGTVPVGRVETGILRPGMVVTFAPVNITTEVKSVEMHHEALS ::::::::::::::::::::::::::::::.:.:::::::::::.::::::::::::::: XP_011 PTDKPLRLPLQDVYKIGGIGTVPVGRVETGVLKPGMVVTFAPVNVTTEVKSVEMHHEALS 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE3 EALPGDNVGFNVKNVSVKDIRRGNVCGDSKSDPPQEAAQFTSQVIILNHPGQISAGYSPV :::::::::::::::::::.::::: ::::.:::.::: ::.:::::::::::::::.:: XP_011 EALPGDNVGFNVKNVSVKDVRRGNVAGDSKNDPPMEAAGFTAQVIILNHPGQISAGYAPV 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE3 IDCHTAHIACKFAELKEKIDRRSGKKLEDNPKSLKSGDAAIVEMVPGKPMCVESFSQYPP .::::::::::::::::::::::::::::.:: :::::::::.:::::::::::::.::: XP_011 LDCHTAHIACKFAELKEKIDRRSGKKLEDGPKFLKSGDAAIVDMVPGKPMCVESFSDYPP 370 380 390 400 410 420 430 440 450 460 pF1KE3 LGRFAVRDMRQTVAVGVIKNVEKKSGGAGKVTKSAQKAQKAGK ::::::::::::::::::: :.::..::::::::::::::: XP_011 LGRFAVRDMRQTVAVGVIKAVDKKAAGAGKVTKSAQKAQKAK 430 440 450 460 >>NP_001138630 (OMIM: 612450) HBS1-like protein isoform (642 aa) initn: 939 init1: 632 opt: 739 Z-score: 855.6 bits: 168.1 E(85289): 6.4e-41 Smith-Waterman score: 1079; 39.3% identity (69.3% similar) in 440 aa overlap (5-443:216-642) 10 20 30 pF1KE3 MGKEKTHINIVVIGHVDSGKSTTTGHLIYKCGGI : .:.:::::::.:::: ::..: :.: NP_001 QSSTPAPVKKSGKLRQQIDVKAELEKRQGGKQLLNLVVIGHVDAGKSTLMGHMLYLLGNI 190 200 210 220 230 240 40 50 60 70 80 90 pF1KE3 DKRTIEKFEKEAAEMGKGSFKYAWVLDKLKAERERGITIDISLWKFETTKYYITIIDAPG .:::..:.:.:. . ::.:: ::::::. :::::.:.:... ::::: ::..:::: NP_001 NKRTMHKYEQESKKAGKASFAYAWVLDETGEERERGVTMDVGMTKFETTTKVITLMDAPG 250 260 270 280 290 300 100 110 120 130 140 150 pF1KE3 HRDFIKNMITGTSQADCAVLIVAAGVGEFEAGISKNGQTREHALLAYTLGVKQLIVGVNK :.::: :::::..::: :::.: :. ::::::. .::::::.::. .::: :: :.::: NP_001 HKDFIPNMITGAAQADVAVLVVDASRGEFEAGFETGGQTREHGLLVRSLGVTQLAVAVNK 310 320 330 340 350 360 160 170 180 190 200 210 pF1KE3 MDSTEPAYSEKRYDEIVKEVSAYIKKIGYNPATVPFVPISGWHGDNMLEPSPNMPWFKGW ::... ....:..::. ... ..:. :.. . : :.: :: :.:.. : . : . NP_001 MDQVN--WQQERFQEITGKLGHFLKQAGFKESDVGFIPTSGLSGENLITRSQSSELTKWY 370 380 390 400 410 420 220 230 240 250 260 270 pF1KE3 KVERKEGNASGVSLLEALDTILPPTRPTDKPLRLPLQDVYKIGGIGTVPVGRVETGILRP : :. ::: .:.. :: : :::.:: ..::.: : : .:..:.: .. NP_001 K---------GLCLLEQIDSFKPPQRSIDKPFRLCVSDVFKDQGSGFCITGKIEAGYIQT 430 440 450 460 470 280 290 300 310 320 330 pF1KE3 GMVVTFAPVNITTEVKSVEMHHEALSEALPGDNVGFNVKNVSVKDIRRGNV-CGDSKSDP : . : : : ::.. .: : .. : ::.:.... .... : : . :: . : NP_001 GDRLLAMPPNETCTVKGITLHDEPVDWAAAGDHVSLTLVGMDIIKINVGCIFCGPKV--P 480 490 500 510 520 530 340 350 360 370 380 390 pF1KE3 PQEAAQFTSQVIILNHPGQISAGYSPVIDCHTAHIACKFAELKEKIDRRSGKKLEDNPKS . ..: ....:.: :. :. .. .:. . .: ... .:. . .:: NP_001 IKACTRFRARILIFNIEIPITKGFPVLLHYQTVSEPAVIKRLISVLNKSTGEVTKKKPKF 540 550 560 570 580 590 400 410 420 430 440 450 pF1KE3 LKSGDAAIVEMVPGKPMCVESFSQYPPLGRFAVRDMRQTVAVGVIKNVEKKSGGAGKVTK : .:. :.::. .:. .: .... :::: .: .:.:.::. .... NP_001 LTKGQNALVELQTQRPIALELYKDFKELGRFMLRYGGSTIAAGVVTEIKE 600 610 620 630 640 460 pF1KE3 SAQKAQKAGK >>NP_006611 (OMIM: 612450) HBS1-like protein isoform 1 [ (684 aa) initn: 939 init1: 632 opt: 739 Z-score: 855.2 bits: 168.1 E(85289): 6.7e-41 Smith-Waterman score: 1079; 39.3% identity (69.3% similar) in 440 aa overlap (5-443:258-684) 10 20 30 pF1KE3 MGKEKTHINIVVIGHVDSGKSTTTGHLIYKCGGI : .:.:::::::.:::: ::..: :.: NP_006 QSSTPAPVKKSGKLRQQIDVKAELEKRQGGKQLLNLVVIGHVDAGKSTLMGHMLYLLGNI 230 240 250 260 270 280 40 50 60 70 80 90 pF1KE3 DKRTIEKFEKEAAEMGKGSFKYAWVLDKLKAERERGITIDISLWKFETTKYYITIIDAPG .:::..:.:.:. . ::.:: ::::::. :::::.:.:... ::::: ::..:::: NP_006 NKRTMHKYEQESKKAGKASFAYAWVLDETGEERERGVTMDVGMTKFETTTKVITLMDAPG 290 300 310 320 330 340 100 110 120 130 140 150 pF1KE3 HRDFIKNMITGTSQADCAVLIVAAGVGEFEAGISKNGQTREHALLAYTLGVKQLIVGVNK :.::: :::::..::: :::.: :. ::::::. .::::::.::. .::: :: :.::: NP_006 HKDFIPNMITGAAQADVAVLVVDASRGEFEAGFETGGQTREHGLLVRSLGVTQLAVAVNK 350 360 370 380 390 400 160 170 180 190 200 210 pF1KE3 MDSTEPAYSEKRYDEIVKEVSAYIKKIGYNPATVPFVPISGWHGDNMLEPSPNMPWFKGW ::... ....:..::. ... ..:. :.. . : :.: :: :.:.. : . : . NP_006 MDQVN--WQQERFQEITGKLGHFLKQAGFKESDVGFIPTSGLSGENLITRSQSSELTKWY 410 420 430 440 450 460 220 230 240 250 260 270 pF1KE3 KVERKEGNASGVSLLEALDTILPPTRPTDKPLRLPLQDVYKIGGIGTVPVGRVETGILRP : :. ::: .:.. :: : :::.:: ..::.: : : .:..:.: .. NP_006 K---------GLCLLEQIDSFKPPQRSIDKPFRLCVSDVFKDQGSGFCITGKIEAGYIQT 470 480 490 500 510 280 290 300 310 320 330 pF1KE3 GMVVTFAPVNITTEVKSVEMHHEALSEALPGDNVGFNVKNVSVKDIRRGNV-CGDSKSDP : . : : : ::.. .: : .. : ::.:.... .... : : . :: . : NP_006 GDRLLAMPPNETCTVKGITLHDEPVDWAAAGDHVSLTLVGMDIIKINVGCIFCGPKV--P 520 530 540 550 560 570 340 350 360 370 380 390 pF1KE3 PQEAAQFTSQVIILNHPGQISAGYSPVIDCHTAHIACKFAELKEKIDRRSGKKLEDNPKS . ..: ....:.: :. :. .. .:. . .: ... .:. . .:: NP_006 IKACTRFRARILIFNIEIPITKGFPVLLHYQTVSEPAVIKRLISVLNKSTGEVTKKKPKF 580 590 600 610 620 630 400 410 420 430 440 450 pF1KE3 LKSGDAAIVEMVPGKPMCVESFSQYPPLGRFAVRDMRQTVAVGVIKNVEKKSGGAGKVTK : .:. :.::. .:. .: .... :::: .: .:.:.::. .... NP_006 LTKGQNALVELQTQRPIALELYKDFKELGRFMLRYGGSTIAAGVVTEIKE 640 650 660 670 680 460 pF1KE3 SAQKAQKAGK >>NP_001123479 (OMIM: 139259) eukaryotic peptide chain r (499 aa) initn: 886 init1: 640 opt: 704 Z-score: 816.7 bits: 160.5 E(85289): 9.5e-39 Smith-Waterman score: 1020; 37.2% identity (67.5% similar) in 443 aa overlap (4-444:71-498) 10 20 30 pF1KE3 MGKEKTHINIVVIGHVDSGKSTTTGHLIYKCGG .: :.:.: :::::.:::: :...: : NP_001 RPPEESAHEMMEEEEEIPKPKSVVAPPGAPKKEHVNVVFIGHVDAGKSTIGGQIMYLTGM 50 60 70 80 90 100 40 50 60 70 80 90 pF1KE3 IDKRTIEKFEKEAAEMGKGSFKYAWVLDKLKAERERGITIDISLWKFETTKYYITIIDAP .::::.::.:.:: : .. .. .:.:: . ::..: :.... ::: : ..::.::: NP_001 VDKRTLEKYEREAKEKNRETWYLSWALDTNQEERDKGKTVEVGRAYFETEKKHFTILDAP 110 120 130 140 150 160 100 110 120 130 140 150 pF1KE3 GHRDFIKNMITGTSQADCAVLIVAAGVGEFEAGISKNGQTREHALLAYTLGVKQLIVGVN ::..:. ::: :.:::: :::...: ::::.:. :.:::::::.:: : :::.::: .: NP_001 GHKSFVPNMIGGASQADLAVLVISARKGEFETGFEKGGQTREHAMLAKTAGVKHLIVLIN 170 180 190 200 210 220 160 170 180 190 200 210 pF1KE3 KMDSTEPAYSEKRYDEIVKEVSAYIKKIGYNPAT-VPFVPISGWHGDNMLEPSPNMPWFK :::. .:..::.: ... ..::.:.:: . :.: :: : :. : : ::. NP_001 KMDDPTVNWSNERYEECKEKLVPFLKKVGFNPKKDIHFMPCSGLTGANLKEQSDFCPWY- 230 240 250 260 270 220 230 240 250 260 270 pF1KE3 GWKVERKEGNASGVSLLEALDTILPPTRPTDKPLRLPLQDVYKIGGIGTVPVGRVETGIL :. .. ::.. .: .: :.:::. : :: .::: .:..:.: . NP_001 -----------IGLPFIPYLDNLPNFNRSVDGPIRLPIVDKYK--DMGTVVLGKLESGSI 280 290 300 310 320 280 290 300 310 320 330 pF1KE3 RPGMVVTFAPVNITTEVKSVEMHHEALSEALPGDNVGFNVKNVSVKDIRRGNVCGDSKSD :. ... : . ..:: .. . . ::.:. . .:.. ..: : . : .. NP_001 CKGQQLVMMPNKHNVEVLGILSDDVETDTVAPGENLKIRLKGIEEEEILPGFILCDP-NN 330 340 350 360 370 380 340 350 360 370 380 390 pF1KE3 PPQEAAQFTSQVIILNHPGQISAGYSPVIDCHTAHIACKFAELKEKIDRRSGKKLEDNPK . . : .:..:..: . : ::. :. :: ... : .:..::.: . :. NP_001 LCHSGRTFDAQIVIIEHKSIICPGYNAVLHIHTCIEEVEITALICLVDKKSGEKSKTRPR 390 400 410 420 430 440 400 410 420 430 440 450 pF1KE3 SLKSGDAAIVEMVPGKPMCVESFSQYPPLGRFAVRDMRQTVAVG-VIKNVEKKSGGAGKV .:. .. :... . .:.:.:...: .:::..:: .:.:.: :.: : .: NP_001 FVKQDQVCIARLRTAGTICLETFKDFPQMGRFTLRDEGKTIAIGKVLKLVPEKD 450 460 470 480 490 460 pF1KE3 TKSAQKAQKAGK >>NP_001123478 (OMIM: 139259) eukaryotic peptide chain r (636 aa) initn: 886 init1: 640 opt: 704 Z-score: 815.2 bits: 160.6 E(85289): 1.2e-38 Smith-Waterman score: 1020; 37.2% identity (67.5% similar) in 443 aa overlap (4-444:208-635) 10 20 30 pF1KE3 MGKEKTHINIVVIGHVDSGKSTTTGHLIYKCGG .: :.:.: :::::.:::: :...: : NP_001 RPPEESAHEMMEEEEEIPKPKSVVAPPGAPKKEHVNVVFIGHVDAGKSTIGGQIMYLTGM 180 190 200 210 220 230 40 50 60 70 80 90 pF1KE3 IDKRTIEKFEKEAAEMGKGSFKYAWVLDKLKAERERGITIDISLWKFETTKYYITIIDAP .::::.::.:.:: : .. .. .:.:: . ::..: :.... ::: : ..::.::: NP_001 VDKRTLEKYEREAKEKNRETWYLSWALDTNQEERDKGKTVEVGRAYFETEKKHFTILDAP 240 250 260 270 280 290 100 110 120 130 140 150 pF1KE3 GHRDFIKNMITGTSQADCAVLIVAAGVGEFEAGISKNGQTREHALLAYTLGVKQLIVGVN ::..:. ::: :.:::: :::...: ::::.:. :.:::::::.:: : :::.::: .: NP_001 GHKSFVPNMIGGASQADLAVLVISARKGEFETGFEKGGQTREHAMLAKTAGVKHLIVLIN 300 310 320 330 340 350 160 170 180 190 200 210 pF1KE3 KMDSTEPAYSEKRYDEIVKEVSAYIKKIGYNPAT-VPFVPISGWHGDNMLEPSPNMPWFK :::. .:..::.: ... ..::.:.:: . :.: :: : :. : : ::. NP_001 KMDDPTVNWSNERYEECKEKLVPFLKKVGFNPKKDIHFMPCSGLTGANLKEQSDFCPWY- 360 370 380 390 400 410 220 230 240 250 260 270 pF1KE3 GWKVERKEGNASGVSLLEALDTILPPTRPTDKPLRLPLQDVYKIGGIGTVPVGRVETGIL :. .. ::.. .: .: :.:::. : :: .::: .:..:.: . NP_001 -----------IGLPFIPYLDNLPNFNRSVDGPIRLPIVDKYK--DMGTVVLGKLESGSI 420 430 440 450 460 280 290 300 310 320 330 pF1KE3 RPGMVVTFAPVNITTEVKSVEMHHEALSEALPGDNVGFNVKNVSVKDIRRGNVCGDSKSD :. ... : . ..:: .. . . ::.:. . .:.. ..: : . : .. NP_001 CKGQQLVMMPNKHNVEVLGILSDDVETDTVAPGENLKIRLKGIEEEEILPGFILCDP-NN 470 480 490 500 510 520 340 350 360 370 380 390 pF1KE3 PPQEAAQFTSQVIILNHPGQISAGYSPVIDCHTAHIACKFAELKEKIDRRSGKKLEDNPK . . : .:..:..: . : ::. :. :: ... : .:..::.: . :. NP_001 LCHSGRTFDAQIVIIEHKSIICPGYNAVLHIHTCIEEVEITALICLVDKKSGEKSKTRPR 530 540 550 560 570 580 400 410 420 430 440 450 pF1KE3 SLKSGDAAIVEMVPGKPMCVESFSQYPPLGRFAVRDMRQTVAVG-VIKNVEKKSGGAGKV .:. .. :... . .:.:.:...: .:::..:: .:.:.: :.: : .: NP_001 FVKQDQVCIARLRTAGTICLETFKDFPQMGRFTLRDEGKTIAIGKVLKLVPEKD 590 600 610 620 630 460 pF1KE3 TKSAQKAQKAGK >>NP_002085 (OMIM: 139259) eukaryotic peptide chain rele (637 aa) initn: 886 init1: 640 opt: 704 Z-score: 815.1 bits: 160.6 E(85289): 1.2e-38 Smith-Waterman score: 1020; 37.2% identity (67.5% similar) in 443 aa overlap (4-444:209-636) 10 20 30 pF1KE3 MGKEKTHINIVVIGHVDSGKSTTTGHLIYKCGG .: :.:.: :::::.:::: :...: : NP_002 RPPEESAHEMMEEEEEIPKPKSVVAPPGAPKKEHVNVVFIGHVDAGKSTIGGQIMYLTGM 180 190 200 210 220 230 40 50 60 70 80 90 pF1KE3 IDKRTIEKFEKEAAEMGKGSFKYAWVLDKLKAERERGITIDISLWKFETTKYYITIIDAP .::::.::.:.:: : .. .. .:.:: . ::..: :.... ::: : ..::.::: NP_002 VDKRTLEKYEREAKEKNRETWYLSWALDTNQEERDKGKTVEVGRAYFETEKKHFTILDAP 240 250 260 270 280 290 100 110 120 130 140 150 pF1KE3 GHRDFIKNMITGTSQADCAVLIVAAGVGEFEAGISKNGQTREHALLAYTLGVKQLIVGVN ::..:. ::: :.:::: :::...: ::::.:. :.:::::::.:: : :::.::: .: NP_002 GHKSFVPNMIGGASQADLAVLVISARKGEFETGFEKGGQTREHAMLAKTAGVKHLIVLIN 300 310 320 330 340 350 160 170 180 190 200 210 pF1KE3 KMDSTEPAYSEKRYDEIVKEVSAYIKKIGYNPAT-VPFVPISGWHGDNMLEPSPNMPWFK :::. .:..::.: ... ..::.:.:: . :.: :: : :. : : ::. NP_002 KMDDPTVNWSNERYEECKEKLVPFLKKVGFNPKKDIHFMPCSGLTGANLKEQSDFCPWY- 360 370 380 390 400 410 220 230 240 250 260 270 pF1KE3 GWKVERKEGNASGVSLLEALDTILPPTRPTDKPLRLPLQDVYKIGGIGTVPVGRVETGIL :. .. ::.. .: .: :.:::. : :: .::: .:..:.: . NP_002 -----------IGLPFIPYLDNLPNFNRSVDGPIRLPIVDKYK--DMGTVVLGKLESGSI 420 430 440 450 460 280 290 300 310 320 330 pF1KE3 RPGMVVTFAPVNITTEVKSVEMHHEALSEALPGDNVGFNVKNVSVKDIRRGNVCGDSKSD :. ... : . ..:: .. . . ::.:. . .:.. ..: : . : .. NP_002 CKGQQLVMMPNKHNVEVLGILSDDVETDTVAPGENLKIRLKGIEEEEILPGFILCDP-NN 470 480 490 500 510 520 340 350 360 370 380 390 pF1KE3 PPQEAAQFTSQVIILNHPGQISAGYSPVIDCHTAHIACKFAELKEKIDRRSGKKLEDNPK . . : .:..:..: . : ::. :. :: ... : .:..::.: . :. NP_002 LCHSGRTFDAQIVIIEHKSIICPGYNAVLHIHTCIEEVEITALICLVDKKSGEKSKTRPR 530 540 550 560 570 580 400 410 420 430 440 450 pF1KE3 SLKSGDAAIVEMVPGKPMCVESFSQYPPLGRFAVRDMRQTVAVG-VIKNVEKKSGGAGKV .:. .. :... . .:.:.:...: .:::..:: .:.:.: :.: : .: NP_002 FVKQDQVCIARLRTAGTICLETFKDFPQMGRFTLRDEGKTIAIGKVLKLVPEKD 590 600 610 620 630 460 pF1KE3 TKSAQKAQKAGK >>NP_060564 (OMIM: 300418) eukaryotic peptide chain rele (628 aa) initn: 834 init1: 588 opt: 688 Z-score: 796.7 bits: 157.1 E(85289): 1.2e-37 Smith-Waterman score: 1010; 36.8% identity (67.0% similar) in 443 aa overlap (4-444:200-627) 10 20 30 pF1KE3 MGKEKTHINIVVIGHVDSGKSTTTGHLIYKCGG .: :.:.: :::::.:::: :.... : NP_060 GPPEESGQEMMEEKEEIRKSKSVIVPSGAPKKEHVNVVFIGHVDAGKSTIGGQIMFLTGM 170 180 190 200 210 220 40 50 60 70 80 90 pF1KE3 IDKRTIEKFEKEAAEMGKGSFKYAWVLDKLKAERERGITIDISLWKFETTKYYITIIDAP .::::.::.:.:: : .. .. .:.:: . ::..: :.... ::: . ..::.::: NP_060 VDKRTLEKYEREAKEKNRETWYLSWALDTNQEERDKGKTVEVGRAYFETERKHFTILDAP 230 240 250 260 270 280 100 110 120 130 140 150 pF1KE3 GHRDFIKNMITGTSQADCAVLIVAAGVGEFEAGISKNGQTREHALLAYTLGVKQLIVGVN ::..:. ::: :.:::: :::...: ::::.:. :.:::::::.:: : :::.::: .: NP_060 GHKSFVPNMIGGASQADLAVLVISARKGEFETGFEKGGQTREHAMLAKTAGVKHLIVLIN 290 300 310 320 330 340 160 170 180 190 200 210 pF1KE3 KMDSTEPAYSEKRYDEIVKEVSAYIKKIGYNPAT-VPFVPISGWHGDNMLEPSPNMPWFK :::. .: .::.: ... ..::.:..: . :.: :: : :. : : ::. NP_060 KMDDPTVNWSIERYEECKEKLVPFLKKVGFSPKKDIHFMPCSGLTGANIKEQSDFCPWY- 350 360 370 380 390 400 220 230 240 250 260 270 pF1KE3 GWKVERKEGNASGVSLLEALDTILPPTRPTDKPLRLPLQDVYKIGGIGTVPVGRVETGIL .:. .. ::.. .: : :.:::. : :: .::: .:..:.: . NP_060 -----------TGLPFIPYLDNLPNFNRSIDGPIRLPIVDKYK--DMGTVVLGKLESGSI 410 420 430 440 450 280 290 300 310 320 330 pF1KE3 RPGMVVTFAPVNITTEVKSVEMHHEALSEALPGDNVGFNVKNVSVKDIRRGNVCGDSKSD :. ... : . ..:: .. . . ::.:. . .:.. ..: : . : :. NP_060 FKGQQLVMMPNKHNVEVLGILSDDTETDFVAPGENLKIRLKGIEEEEILPGFILCDP-SN 460 470 480 490 500 510 340 350 360 370 380 390 pF1KE3 PPQEAAQFTSQVIILNHPGQISAGYSPVIDCHTAHIACKFAELKEKIDRRSGKKLEDNPK . . : :..:..: . : ::. :. :: ... : .:..::.: . :. NP_060 LCHSGRTFDVQIVIIEHKSIICPGYNAVLHIHTCIEEVEITALISLVDKKSGEKSKTRPR 520 530 540 550 560 570 400 410 420 430 440 450 pF1KE3 SLKSGDAAIVEMVPGKPMCVESFSQYPPLGRFAVRDMRQTVAVG-VIKNVEKKSGGAGKV .:. .. :... . .:.:.:...: .:::..:: .:.:.: :.: : .: NP_060 FVKQDQVCIARLRTAGTICLETFKDFPQMGRFTLRDEGKTIAIGKVLKLVPEKD 580 590 600 610 620 460 pF1KE3 TKSAQKAQKAGK >>XP_011544230 (OMIM: 602389,610678) PREDICTED: elongati (427 aa) initn: 511 init1: 191 opt: 267 Z-score: 311.7 bits: 66.8 E(85289): 1.3e-10 Smith-Waterman score: 490; 30.6% identity (53.0% similar) in 447 aa overlap (3-440:56-413) 10 20 30 pF1KE3 MGKEKTHINIVVIGHVDSGKSTTTGHLIYKCG ..: :.:. .::::: ::.: :. . XP_011 LLQGLLRLLKAPALPLLCRGLAVEAKKTYVRDKPHVNVGTIGHVDHGKTTLTAAIT---- 30 40 50 60 70 80 40 50 60 70 80 90 pF1KE3 GIDKRTIEKFEKEAAEMGKGSFKYAWVLDKLKAERERGITIDISLWKFETTKYYITIIDA : :: : ..:: .:. :: :::::. . .. :. . . : XP_011 -----------KILAEGGGAKFKKYEEIDNAPEERARGITINAAHVEYSTAARHYAHTDC 90 100 110 120 130 100 110 120 130 140 150 pF1KE3 PGHRDFIKNMITGTSQADCAVLIVAAGVGEFEAGISKNGQTREHALLAYTLGVKQLIVGV ::: :..:::::::. : .:.:::. : . ::::: ::: .::....: : XP_011 PGHADYVKNMITGTAPLDGCILVVAANDGPMP-------QTREHLLLARQIGVEHVVVYV 140 150 160 170 180 160 170 180 190 200 210 pF1KE3 NKMDSTEPAYSEKRYDEIVK-EVSAYIKKIGYNPATVPFVPISGWHGDNMLEP-SPNMPW :: : : ..... :.:. :. . ..::. .: . :. :: .:.. XP_011 NKAD----AVQDSEMVELVELEIRELLTEFGYKGEETPVIVGSAL---CALEGRDPEL-- 190 200 210 220 230 220 230 240 250 260 pF1KE3 FKGWKVERKEGNASGVSLLEALDTILP-PTRPTDKPLRLPLQDVYKIGGIGTVPVGRVET : : .: ::.:.:: .: :.: .::. ::.. ::.. : ::: .: XP_011 --GLKSVQK--------LLDAVDTYIPVPARDLEKPFLLPVEAVYSVPGRGTVVTG---- 240 250 260 270 280 270 280 290 300 310 320 pF1KE3 GILRPGMVVTFAPVNITTEVKSVEMHHEALSEALPGDNVGFNVKNVSVKDIRRGNVCGDS .:: :..: .: :::.: :.... .:.::: : XP_011 ----------------------IEMFHKSLERAEAGDNLGALVRGLKREDLRRGLVMVKP 290 300 310 330 340 350 360 370 380 pF1KE3 KSDPPQEAAQFTSQVIILN------HPGQISAGYSPVIDCHTAHIACKFAELKEKIDRRS : :.. .. .:: ::. : .: . ::. : .::.. :: XP_011 GSIKPHQKVE--AQVYILSKEEGGRHKPFVSH-FMPVMFSLTWDMACRIILPPEKELAMP 320 330 340 350 360 370 390 400 410 420 430 440 pF1KE3 GKKLEDNPKSLKSGDAAIVEMVPGKPMCVESFSQYPPLGRFAVRDMRQTVAVGVIKNVEK :. :. : .. .:: .:. .: ::..:: .:...:.. : XP_011 GEDLKFN-------------LILRQPMILEK-GQ-----RFTLRDGNRTIGTGLVTNTLA 380 390 400 410 450 460 pF1KE3 KSGGAGKVTKSAQKAQKAGK XP_011 MTEEEKNIKWG 420 463 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 23:35:32 2016 done: Sun Nov 6 23:35:33 2016 Total Scan time: 7.010 Total Display time: 0.060 Function used was FASTA [36.3.4 Apr, 2011]