Result of FASTA (omim) for
pFN21AE1062
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE1062, 1454 aa
1>>>pF1KE1062 1454 - 1454 aa - 1454 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 12.4234+/-0.000566; mu= -11.3296+/- 0.035
mean_var=447.5221+/-96.140, 0's: 0 Z-trim(118.4): 515 B-trim: 476 in 2/56
Lambda= 0.060627
statistics sampled from 30763 (31382) to 30763 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.684), E-opt: 0.2 (0.368), width: 16
Scan time: 19.480
The best scores are: opt bits E(85289)
XP_016877721 (OMIM: 601907) PREDICTED: neogenin is (1454) 9689 863.8 0
XP_016877724 (OMIM: 601907) PREDICTED: neogenin is (1401) 8261 738.9 6.4e-212
XP_011519934 (OMIM: 601907) PREDICTED: neogenin is (1447) 8119 726.5 3.6e-208
XP_011519932 (OMIM: 601907) PREDICTED: neogenin is (1465) 7064 634.2 2.2e-180
XP_016877723 (OMIM: 601907) PREDICTED: neogenin is (1412) 7049 632.9 5.2e-180
NP_002490 (OMIM: 601907) neogenin isoform 1 precur (1461) 6810 612.0 1.1e-173
NP_001166095 (OMIM: 601907) neogenin isoform 3 pre (1450) 6799 611.0 2e-173
XP_016877720 (OMIM: 601907) PREDICTED: neogenin is (1434) 6714 603.6 3.5e-171
XP_016877726 (OMIM: 601907) PREDICTED: neogenin is (1394) 6677 600.4 3.2e-170
XP_016877722 (OMIM: 601907) PREDICTED: neogenin is (1417) 5637 509.4 7.9e-143
XP_011519931 (OMIM: 601907) PREDICTED: neogenin is (1470) 5623 508.2 1.9e-142
XP_011519935 (OMIM: 601907) PREDICTED: neogenin is (1428) 5618 507.7 2.5e-142
XP_005254465 (OMIM: 601907) PREDICTED: neogenin is (1481) 5618 507.8 2.6e-142
XP_011519930 (OMIM: 601907) PREDICTED: neogenin is (1481) 5618 507.8 2.6e-142
XP_016877725 (OMIM: 601907) PREDICTED: neogenin is (1397) 5400 488.7 1.4e-136
NP_001166094 (OMIM: 601907) neogenin isoform 2 pre (1408) 5393 488.1 2.1e-136
XP_016877727 (OMIM: 601907) PREDICTED: neogenin is (1381) 5286 478.7 1.4e-133
XP_016881058 (OMIM: 114500,120470,133239,157600) P (1427) 2917 271.5 3.3e-71
NP_005206 (OMIM: 114500,120470,133239,157600) netr (1447) 2603 244.0 6.2e-63
XP_016881057 (OMIM: 114500,120470,133239,157600) P (1445) 2600 243.8 7.4e-63
XP_011524145 (OMIM: 114500,120470,133239,157600) P (1443) 2497 234.8 3.8e-60
XP_016881059 (OMIM: 114500,120470,133239,157600) P (1102) 1641 159.8 1.1e-37
XP_011524146 (OMIM: 114500,120470,133239,157600) P (1102) 1641 159.8 1.1e-37
XP_016862494 (OMIM: 602431,610878) PREDICTED: roun (1396) 798 86.1 2e-15
XP_016862493 (OMIM: 602431,610878) PREDICTED: roun (1398) 798 86.1 2e-15
XP_016862486 (OMIM: 602431,610878) PREDICTED: roun (1438) 798 86.2 2.1e-15
XP_016862485 (OMIM: 602431,610878) PREDICTED: roun (1440) 798 86.2 2.1e-15
XP_016862481 (OMIM: 602431,610878) PREDICTED: roun (1489) 798 86.2 2.1e-15
XP_016862479 (OMIM: 602431,610878) PREDICTED: roun (1531) 798 86.2 2.2e-15
XP_016862491 (OMIM: 602431,610878) PREDICTED: roun (1402) 788 85.3 3.7e-15
XP_016862490 (OMIM: 602431,610878) PREDICTED: roun (1403) 788 85.3 3.7e-15
XP_011532287 (OMIM: 602431,610878) PREDICTED: roun (1405) 788 85.3 3.7e-15
XP_016862484 (OMIM: 602431,610878) PREDICTED: roun (1442) 788 85.3 3.8e-15
XP_016862483 (OMIM: 602431,610878) PREDICTED: roun (1445) 788 85.3 3.8e-15
XP_011532286 (OMIM: 602431,610878) PREDICTED: roun (1447) 788 85.3 3.8e-15
XP_016862480 (OMIM: 602431,610878) PREDICTED: roun (1496) 788 85.3 3.9e-15
XP_016862477 (OMIM: 602431,610878) PREDICTED: roun (1536) 788 85.3 4e-15
XP_011532285 (OMIM: 602431,610878) PREDICTED: roun (1538) 788 85.3 4e-15
XP_016862476 (OMIM: 602431,610878) PREDICTED: roun (1554) 788 85.3 4e-15
XP_011532284 (OMIM: 602431,610878) PREDICTED: roun (1557) 788 85.3 4e-15
XP_011532283 (OMIM: 602431,610878) PREDICTED: roun (1597) 788 85.3 4.1e-15
XP_016862495 (OMIM: 602431,610878) PREDICTED: roun (1379) 781 84.7 5.6e-15
NP_001276968 (OMIM: 602431,610878) roundabout homo (1382) 781 84.7 5.6e-15
XP_016862471 (OMIM: 602430) PREDICTED: roundabout (1626) 783 84.9 5.6e-15
XP_016862488 (OMIM: 602431,610878) PREDICTED: roun (1422) 781 84.7 5.7e-15
XP_016862487 (OMIM: 602431,610878) PREDICTED: roun (1424) 781 84.7 5.7e-15
NP_001276969 (OMIM: 602431,610878) roundabout homo (1443) 781 84.7 5.8e-15
XP_016862475 (OMIM: 602431,610878) PREDICTED: roun (1576) 781 84.7 6.2e-15
NP_598334 (OMIM: 602430) roundabout homolog 1 isof (1606) 780 84.6 6.7e-15
XP_011532280 (OMIM: 602430) PREDICTED: roundabout (1645) 780 84.6 6.8e-15
>>XP_016877721 (OMIM: 601907) PREDICTED: neogenin isofor (1454 aa)
initn: 9689 init1: 9689 opt: 9689 Z-score: 4600.5 bits: 863.8 E(85289): 0
Smith-Waterman score: 9689; 100.0% identity (100.0% similar) in 1454 aa overlap (1-1454:1-1454)
10 20 30 40 50 60
pF1KE1 MAAERGARRLLSTPSFWLYCLLLLGRRAPGAAAARSGSAPQSPGASIRTFTPFYFLVEPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MAAERGARRLLSTPSFWLYCLLLLGRRAPGAAAARSGSAPQSPGASIRTFTPFYFLVEPV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 DTLSVRGSSVILNCSAYSEPSPKIEWKKDGTFLNLVSDDRRQLLPDGSLFISNVVHSKHN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DTLSVRGSSVILNCSAYSEPSPKIEWKKDGTFLNLVSDDRRQLLPDGSLFISNVVHSKHN
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 KPDEGYYQCVATVESLGTIISRTAKLIVAGLPRFTSQPEPSSVYAGNNAILNCEVNADLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KPDEGYYQCVATVESLGTIISRTAKLIVAGLPRFTSQPEPSSVYAGNNAILNCEVNADLV
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE1 PFVRWEQNRQPLLLDDRVIKLPSGMLVISNATEGDGGLYRCVVESGGPPKYSDEVELKVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PFVRWEQNRQPLLLDDRVIKLPSGMLVISNATEGDGGLYRCVVESGGPPKYSDEVELKVL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE1 PDPEVISDLVFLKQPSPLVRVIGQDVVLPCVASGLPTPTIKWMKNEEALDTESSERLVLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PDPEVISDLVFLKQPSPLVRVIGQDVVLPCVASGLPTPTIKWMKNEEALDTESSERLVLL
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE1 AGGSLEISDVTEDDAGTYFCIADNGNETIEAQAELTVQAQPEFLKQPTNIYAHESMDIVF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AGGSLEISDVTEDDAGTYFCIADNGNETIEAQAELTVQAQPEFLKQPTNIYAHESMDIVF
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE1 ECEVTGKPTPTVKWVKNGDMVIPSDYFKIVKEHNLQVLGLVKSDEGFYQCIAENDVGNAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ECEVTGKPTPTVKWVKNGDMVIPSDYFKIVKEHNLQVLGLVKSDEGFYQCIAENDVGNAQ
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE1 AGAQLIILEHDVAIPTLPPTSLTSATTDHLAPATTGPLPSAPRDVVASLVSTRFIKLTWR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AGAQLIILEHDVAIPTLPPTSLTSATTDHLAPATTGPLPSAPRDVVASLVSTRFIKLTWR
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE1 TPASDPHGDNLTYSVFYTKEGIARERVENTSHPGEMQVTIQNLMPATVYIFRVMAQNKHG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TPASDPHGDNLTYSVFYTKEGIARERVENTSHPGEMQVTIQNLMPATVYIFRVMAQNKHG
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE1 SGESSAPLRVETQPEVQLPGPAPNLRAYAASPTSITVTWETPVSGNGEIQNYKLYYMEKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SGESSAPLRVETQPEVQLPGPAPNLRAYAASPTSITVTWETPVSGNGEIQNYKLYYMEKG
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE1 TDKEQDVDVSSHSYTINGLKKYTEYSFRVVAYNKHGPGVSTPDVAVRTLSDVPSAAPQNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TDKEQDVDVSSHSYTINGLKKYTEYSFRVVAYNKHGPGVSTPDVAVRTLSDVPSAAPQNL
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE1 SLEVRNSKSIMIHWQPPAPATQNGQITGYKIRYRKASRKSDVTETLVSGTQLSQLIEGLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SLEVRNSKSIMIHWQPPAPATQNGQITGYKIRYRKASRKSDVTETLVSGTQLSQLIEGLD
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE1 RGTEYNFRVAALTINGTGPATDWLSAETFESDLDETRVPEVPSSLHVRPLVTSIVVSWTP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RGTEYNFRVAALTINGTGPATDWLSAETFESDLDETRVPEVPSSLHVRPLVTSIVVSWTP
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE1 PENQNIVVRGYAIGYGIGSPHAQTIKVDYKQRYYTIENLDPSSHYVITLKAFNNVGEGIP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PENQNIVVRGYAIGYGIGSPHAQTIKVDYKQRYYTIENLDPSSHYVITLKAFNNVGEGIP
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE1 LYESAVTRPHTVPDPTPMMPPVGVQASILSHDTIRITWADNSLPKHQKITDSRYYTVRWK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LYESAVTRPHTVPDPTPMMPPVGVQASILSHDTIRITWADNSLPKHQKITDSRYYTVRWK
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE1 TNIPANTKYKNANATTLSYLVTGLKPNTLYEFSVMVTKGRRSSTWSMTAHGTTFELVPTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TNIPANTKYKNANATTLSYLVTGLKPNTLYEFSVMVTKGRRSSTWSMTAHGTTFELVPTS
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE1 PPKDVTVVSKEGKPKTIIVNWQPPSEANGKITGYIIYYSTDVNAEIHDWVIEPVVGNRLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PPKDVTVVSKEGKPKTIIVNWQPPSEANGKITGYIIYYSTDVNAEIHDWVIEPVVGNRLT
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KE1 HQIQELTLDTPYYFKIQARNSKGMGPMSEAVQFRTPKASGSGGKGSRLPDLGSDYKPPMS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HQIQELTLDTPYYFKIQARNSKGMGPMSEAVQFRTPKASGSGGKGSRLPDLGSDYKPPMS
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KE1 GSNSPHGSPTSPLDSNMLLVIIVSVGVITIVVVVIIAVFCTRRTTSHQKKKRAACKSVNG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GSNSPHGSPTSPLDSNMLLVIIVSVGVITIVVVVIIAVFCTRRTTSHQKKKRAACKSVNG
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KE1 SHKYKGNSKDVKPPDLWIHHERLELKPIDKSPDPNPIMTDTPIPRNSQDITPVDNSMDSN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SHKYKGNSKDVKPPDLWIHHERLELKPIDKSPDPNPIMTDTPIPRNSQDITPVDNSMDSN
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KE1 IHQRRNSYRGHESEDSMSTLAGRRGMRPKMMMPFDSQPPQPVISAHPIHSLDNPHHHFHS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IHQRRNSYRGHESEDSMSTLAGRRGMRPKMMMPFDSQPPQPVISAHPIHSLDNPHHHFHS
1210 1220 1230 1240 1250 1260
1270 1280 1290 1300 1310 1320
pF1KE1 SSLASPARSHLYHPGSPWPIGTSMSLSDRANSTESVRNTPSTDTMPASSSQTCCTDHQDP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SSLASPARSHLYHPGSPWPIGTSMSLSDRANSTESVRNTPSTDTMPASSSQTCCTDHQDP
1270 1280 1290 1300 1310 1320
1330 1340 1350 1360 1370 1380
pF1KE1 EGATSSSYLASSQEEDSGQSLPTAHVRPSHPLKSFAVPAIPPPGPPTYDPALPSTPLLSQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EGATSSSYLASSQEEDSGQSLPTAHVRPSHPLKSFAVPAIPPPGPPTYDPALPSTPLLSQ
1330 1340 1350 1360 1370 1380
1390 1400 1410 1420 1430 1440
pF1KE1 QALNHHIHSVKTASIGTLGRSRPPMPVVVPSAPEVQETTRMLEDSESSYEPDELTKEMAH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QALNHHIHSVKTASIGTLGRSRPPMPVVVPSAPEVQETTRMLEDSESSYEPDELTKEMAH
1390 1400 1410 1420 1430 1440
1450
pF1KE1 LEGLMKDLNAITTA
::::::::::::::
XP_016 LEGLMKDLNAITTA
1450
>>XP_016877724 (OMIM: 601907) PREDICTED: neogenin isofor (1401 aa)
initn: 8596 init1: 8247 opt: 8261 Z-score: 3925.6 bits: 738.9 E(85289): 6.4e-212
Smith-Waterman score: 9191; 96.3% identity (96.4% similar) in 1454 aa overlap (1-1454:1-1401)
10 20 30 40 50 60
pF1KE1 MAAERGARRLLSTPSFWLYCLLLLGRRAPGAAAARSGSAPQSPGASIRTFTPFYFLVEPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MAAERGARRLLSTPSFWLYCLLLLGRRAPGAAAARSGSAPQSPGASIRTFTPFYFLVEPV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 DTLSVRGSSVILNCSAYSEPSPKIEWKKDGTFLNLVSDDRRQLLPDGSLFISNVVHSKHN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DTLSVRGSSVILNCSAYSEPSPKIEWKKDGTFLNLVSDDRRQLLPDGSLFISNVVHSKHN
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 KPDEGYYQCVATVESLGTIISRTAKLIVAGLPRFTSQPEPSSVYAGNNAILNCEVNADLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KPDEGYYQCVATVESLGTIISRTAKLIVAGLPRFTSQPEPSSVYAGNNAILNCEVNADLV
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE1 PFVRWEQNRQPLLLDDRVIKLPSGMLVISNATEGDGGLYRCVVESGGPPKYSDEVELKVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PFVRWEQNRQPLLLDDRVIKLPSGMLVISNATEGDGGLYRCVVESGGPPKYSDEVELKVL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE1 PDPEVISDLVFLKQPSPLVRVIGQDVVLPCVASGLPTPTIKWMKNEEALDTESSERLVLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PDPEVISDLVFLKQPSPLVRVIGQDVVLPCVASGLPTPTIKWMKNEEALDTESSERLVLL
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE1 AGGSLEISDVTEDDAGTYFCIADNGNETIEAQAELTVQAQPEFLKQPTNIYAHESMDIVF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AGGSLEISDVTEDDAGTYFCIADNGNETIEAQAELTVQAQPEFLKQPTNIYAHESMDIVF
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE1 ECEVTGKPTPTVKWVKNGDMVIPSDYFKIVKEHNLQVLGLVKSDEGFYQCIAENDVGNAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ECEVTGKPTPTVKWVKNGDMVIPSDYFKIVKEHNLQVLGLVKSDEGFYQCIAENDVGNAQ
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE1 AGAQLIILEHDVAIPTLPPTSLTSATTDHLAPATTGPLPSAPRDVVASLVSTRFIKLTWR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AGAQLIILEHDVAIPTLPPTSLTSATTDHLAPATTGPLPSAPRDVVASLVSTRFIKLTWR
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE1 TPASDPHGDNLTYSVFYTKEGIARERVENTSHPGEMQVTIQNLMPATVYIFRVMAQNKHG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TPASDPHGDNLTYSVFYTKEGIARERVENTSHPGEMQVTIQNLMPATVYIFRVMAQNKHG
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE1 SGESSAPLRVETQPEVQLPGPAPNLRAYAASPTSITVTWETPVSGNGEIQNYKLYYMEKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SGESSAPLRVETQPEVQLPGPAPNLRAYAASPTSITVTWETPVSGNGEIQNYKLYYMEKG
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE1 TDKEQDVDVSSHSYTINGLKKYTEYSFRVVAYNKHGPGVSTPDVAVRTLSDVPSAAPQNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TDKEQDVDVSSHSYTINGLKKYTEYSFRVVAYNKHGPGVSTPDVAVRTLSDVPSAAPQNL
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE1 SLEVRNSKSIMIHWQPPAPATQNGQITGYKIRYRKASRKSDVTETLVSGTQLSQLIEGLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SLEVRNSKSIMIHWQPPAPATQNGQITGYKIRYRKASRKSDVTETLVSGTQLSQLIEGLD
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE1 RGTEYNFRVAALTINGTGPATDWLSAETFESDLDETRVPEVPSSLHVRPLVTSIVVSWTP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RGTEYNFRVAALTINGTGPATDWLSAETFESDLDETRVPEVPSSLHVRPLVTSIVVSWTP
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE1 PENQNIVVRGYAIGYGIGSPHAQTIKVDYKQRYYTIENLDPSSHYVITLKAFNNVGEGIP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PENQNIVVRGYAIGYGIGSPHAQTIKVDYKQRYYTIENLDPSSHYVITLKAFNNVGEGIP
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE1 LYESAVTRPHTVPDPTPMMPPVGVQASILSHDTIRITWADNSLPKHQKITDSRYYTVRWK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LYESAVTRPHTVPDPTPMMPPVGVQASILSHDTIRITWADNSLPKHQKITDSRYYTVRWK
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE1 TNIPANTKYKNANATTLSYLVTGLKPNTLYEFSVMVTKGRRSSTWSMTAHGTTFELVPTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TNIPANTKYKNANATTLSYLVTGLKPNTLYEFSVMVTKGRRSSTWSMTAHGTTFELVPTS
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE1 PPKDVTVVSKEGKPKTIIVNWQPPSEANGKITGYIIYYSTDVNAEIHDWVIEPVVGNRLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PPKDVTVVSKEGKPKTIIVNWQPPSEANGKITGYIIYYSTDVNAEIHDWVIEPVVGNRLT
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KE1 HQIQELTLDTPYYFKIQARNSKGMGPMSEAVQFRTPKASGSGGKGSRLPDLGSDYKPPMS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HQIQELTLDTPYYFKIQARNSKGMGPMSEAVQFRTPKASGSGGKGSRLPDLGSDYKPPMS
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KE1 GSNSPHGSPTSPLDSNMLLVIIVSVGVITIVVVVIIAVFCTRRTTSHQKKKRAACKSVNG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GSNSPHGSPTSPLDSNMLLVIIVSVGVITIVVVVIIAVFCTRRTTSHQKKKRAACKSVNG
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KE1 SHKYKGNSKDVKPPDLWIHHERLELKPIDKSPDPNPIMTDTPIPRNSQDITPVDNSMDSN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SHKYKGNSKDVKPPDLWIHHERLELKPIDKSPDPNPIMTDTPIPRNSQDITPVDNSMDSN
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KE1 IHQRRNSYRGHESEDSMSTLAGRRGMRPKMMMPFDSQPPQPVISAHPIHSLDNPHHHFHS
::::::::::::::::::::::::::::::::::::::::
XP_016 IHQRRNSYRGHESEDSMSTLAGRRGMRPKMMMPFDSQPPQ--------------------
1210 1220 1230 1240
1270 1280 1290 1300 1310 1320
pF1KE1 SSLASPARSHLYHPGSPWPIGTSMSLSDRANSTESVRNTPSTDTMPASSSQTCCTDHQDP
.::::::::::::::::::::::::::
XP_016 ---------------------------------QSVRNTPSTDTMPASSSQTCCTDHQDP
1250 1260
1330 1340 1350 1360 1370 1380
pF1KE1 EGATSSSYLASSQEEDSGQSLPTAHVRPSHPLKSFAVPAIPPPGPPTYDPALPSTPLLSQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EGATSSSYLASSQEEDSGQSLPTAHVRPSHPLKSFAVPAIPPPGPPTYDPALPSTPLLSQ
1270 1280 1290 1300 1310 1320
1390 1400 1410 1420 1430 1440
pF1KE1 QALNHHIHSVKTASIGTLGRSRPPMPVVVPSAPEVQETTRMLEDSESSYEPDELTKEMAH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QALNHHIHSVKTASIGTLGRSRPPMPVVVPSAPEVQETTRMLEDSESSYEPDELTKEMAH
1330 1340 1350 1360 1370 1380
1450
pF1KE1 LEGLMKDLNAITTA
::::::::::::::
XP_016 LEGLMKDLNAITTA
1390 1400
>>XP_011519934 (OMIM: 601907) PREDICTED: neogenin isofor (1447 aa)
initn: 8137 init1: 5611 opt: 8119 Z-score: 3858.3 bits: 726.5 E(85289): 3.6e-208
Smith-Waterman score: 9431; 97.3% identity (97.3% similar) in 1470 aa overlap (1-1454:1-1447)
10 20 30 40 50 60
pF1KE1 MAAERGARRLLSTPSFWLYCLLLLGRRAPGAAAARSGSAPQSPGASIRTFTPFYFLVEPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MAAERGARRLLSTPSFWLYCLLLLGRRAPGAAAARSGSAPQSPGASIRTFTPFYFLVEPV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 DTLSVRGSSVILNCSAYSEPSPKIEWKKDGTFLNLVSDDRRQLLPDGSLFISNVVHSKHN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DTLSVRGSSVILNCSAYSEPSPKIEWKKDGTFLNLVSDDRRQLLPDGSLFISNVVHSKHN
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 KPDEGYYQCVATVESLGTIISRTAKLIVAGLPRFTSQPEPSSVYAGNNAILNCEVNADLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KPDEGYYQCVATVESLGTIISRTAKLIVAGLPRFTSQPEPSSVYAGNNAILNCEVNADLV
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE1 PFVRWEQNRQPLLLDDRVIKLPSGMLVISNATEGDGGLYRCVVESGGPPKYSDEVELKVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PFVRWEQNRQPLLLDDRVIKLPSGMLVISNATEGDGGLYRCVVESGGPPKYSDEVELKVL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE1 PDPEVISDLVFLKQPSPLVRVIGQDVVLPCVASGLPTPTIKWMKNEEALDTESSERLVLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PDPEVISDLVFLKQPSPLVRVIGQDVVLPCVASGLPTPTIKWMKNEEALDTESSERLVLL
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE1 AGGSLEISDVTEDDAGTYFCIADNGNETIEAQAELTVQAQPEFLKQPTNIYAHESMDIVF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AGGSLEISDVTEDDAGTYFCIADNGNETIEAQAELTVQAQPEFLKQPTNIYAHESMDIVF
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE1 ECEVTGKPTPTVKWVKNGDMVIPSDYFKIVKEHNLQVLGLVKSDEGFYQCIAENDVGNAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ECEVTGKPTPTVKWVKNGDMVIPSDYFKIVKEHNLQVLGLVKSDEGFYQCIAENDVGNAQ
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE1 AGAQLIILEHDVAIPTLPPTSLTSATTDHLAPATTGPLPSAPRDVVASLVSTRFIKLTWR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AGAQLIILEHDVAIPTLPPTSLTSATTDHLAPATTGPLPSAPRDVVASLVSTRFIKLTWR
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE1 TPASDPHGDNLTYSVFYTKEGIARERVENTSHPGEMQVTIQNLMPATVYIFRVMAQNKHG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TPASDPHGDNLTYSVFYTKEGIARERVENTSHPGEMQVTIQNLMPATVYIFRVMAQNKHG
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE1 SGESSAPLRVETQPEVQLPGPAPNLRAYAASPTSITVTWETPVSGNGEIQNYKLYYMEKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SGESSAPLRVETQPEVQLPGPAPNLRAYAASPTSITVTWETPVSGNGEIQNYKLYYMEKG
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE1 TDKEQDVDVSSHSYTINGLKKYTEYSFRVVAYNKHGPGVSTPDVAVRTLSDVPSAAPQNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TDKEQDVDVSSHSYTINGLKKYTEYSFRVVAYNKHGPGVSTPDVAVRTLSDVPSAAPQNL
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE1 SLEVRNSKSIMIHWQPPAPATQNGQITGYKIRYRKASRKSDVTETLVSGTQLSQLIEGLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SLEVRNSKSIMIHWQPPAPATQNGQITGYKIRYRKASRKSDVTETLVSGTQLSQLIEGLD
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE1 RGTEYNFRVAALTINGTGPATDWLSAETFESDLDETRVPEVPSSLHVRPLVTSIVVSWTP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RGTEYNFRVAALTINGTGPATDWLSAETFESDLDETRVPEVPSSLHVRPLVTSIVVSWTP
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE1 PENQNIVVRGYAIGYGIGSPHAQTIKVDYKQRYYTIENLDPSSHYVITLKAFNNVGEGIP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PENQNIVVRGYAIGYGIGSPHAQTIKVDYKQRYYTIENLDPSSHYVITLKAFNNVGEGIP
790 800 810 820 830 840
850 860 870 880
pF1KE1 LYESAVTRPHT----------------VPDPTPMMPPVGVQASILSHDTIRITWADNSLP
::::::::::: :::::::::::::::::::::::::::::::::
XP_011 LYESAVTRPHTDTSEVDLFVINAPYTPVPDPTPMMPPVGVQASILSHDTIRITWADNSLP
850 860 870 880 890 900
890 900 910 920 930 940
pF1KE1 KHQKITDSRYYTVRWKTNIPANTKYKNANATTLSYLVTGLKPNTLYEFSVMVTKGRRSST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KHQKITDSRYYTVRWKTNIPANTKYKNANATTLSYLVTGLKPNTLYEFSVMVTKGRRSST
910 920 930 940 950 960
950 960 970 980 990 1000
pF1KE1 WSMTAHGTTFELVPTSPPKDVTVVSKEGKPKTIIVNWQPPSEANGKITGYIIYYSTDVNA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 WSMTAHGTTFELVPTSPPKDVTVVSKEGKPKTIIVNWQPPSEANGKITGYIIYYSTDVNA
970 980 990 1000 1010 1020
1010 1020 1030 1040 1050 1060
pF1KE1 EIHDWVIEPVVGNRLTHQIQELTLDTPYYFKIQARNSKGMGPMSEAVQFRTPKASGSGGK
:::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EIHDWVIEPVVGNRLTHQIQELTLDTPYYFKIQARNSKGMGPMSEAVQFRTPK-------
1030 1040 1050 1060 1070
1070 1080 1090 1100 1110 1120
pF1KE1 GSRLPDLGSDYKPPMSGSNSPHGSPTSPLDSNMLLVIIVSVGVITIVVVVIIAVFCTRRT
::::::::::::::::::::::::::::::::::::::::::::
XP_011 ----------------GSNSPHGSPTSPLDSNMLLVIIVSVGVITIVVVVIIAVFCTRRT
1080 1090 1100 1110
1130 1140 1150 1160 1170 1180
pF1KE1 TSHQKKKRAACKSVNGSHKYKGNSKDVKPPDLWIHHERLELKPIDKSPDPNPIMTDTPIP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TSHQKKKRAACKSVNGSHKYKGNSKDVKPPDLWIHHERLELKPIDKSPDPNPIMTDTPIP
1120 1130 1140 1150 1160 1170
1190 1200 1210 1220 1230 1240
pF1KE1 RNSQDITPVDNSMDSNIHQRRNSYRGHESEDSMSTLAGRRGMRPKMMMPFDSQPPQPVIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RNSQDITPVDNSMDSNIHQRRNSYRGHESEDSMSTLAGRRGMRPKMMMPFDSQPPQPVIS
1180 1190 1200 1210 1220 1230
1250 1260 1270 1280 1290 1300
pF1KE1 AHPIHSLDNPHHHFHSSSLASPARSHLYHPGSPWPIGTSMSLSDRANSTESVRNTPSTDT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AHPIHSLDNPHHHFHSSSLASPARSHLYHPGSPWPIGTSMSLSDRANSTESVRNTPSTDT
1240 1250 1260 1270 1280 1290
1310 1320 1330 1340 1350 1360
pF1KE1 MPASSSQTCCTDHQDPEGATSSSYLASSQEEDSGQSLPTAHVRPSHPLKSFAVPAIPPPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MPASSSQTCCTDHQDPEGATSSSYLASSQEEDSGQSLPTAHVRPSHPLKSFAVPAIPPPG
1300 1310 1320 1330 1340 1350
1370 1380 1390 1400 1410 1420
pF1KE1 PPTYDPALPSTPLLSQQALNHHIHSVKTASIGTLGRSRPPMPVVVPSAPEVQETTRMLED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PPTYDPALPSTPLLSQQALNHHIHSVKTASIGTLGRSRPPMPVVVPSAPEVQETTRMLED
1360 1370 1380 1390 1400 1410
1430 1440 1450
pF1KE1 SESSYEPDELTKEMAHLEGLMKDLNAITTA
::::::::::::::::::::::::::::::
XP_011 SESSYEPDELTKEMAHLEGLMKDLNAITTA
1420 1430 1440
>>XP_011519932 (OMIM: 601907) PREDICTED: neogenin isofor (1465 aa)
initn: 6999 init1: 6999 opt: 7064 Z-score: 3359.5 bits: 634.2 E(85289): 2.2e-180
Smith-Waterman score: 9657; 99.2% identity (99.2% similar) in 1465 aa overlap (1-1454:1-1465)
10 20 30 40 50 60
pF1KE1 MAAERGARRLLSTPSFWLYCLLLLGRRAPGAAAARSGSAPQSPGASIRTFTPFYFLVEPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MAAERGARRLLSTPSFWLYCLLLLGRRAPGAAAARSGSAPQSPGASIRTFTPFYFLVEPV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 DTLSVRGSSVILNCSAYSEPSPKIEWKKDGTFLNLVSDDRRQLLPDGSLFISNVVHSKHN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DTLSVRGSSVILNCSAYSEPSPKIEWKKDGTFLNLVSDDRRQLLPDGSLFISNVVHSKHN
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 KPDEGYYQCVATVESLGTIISRTAKLIVAGLPRFTSQPEPSSVYAGNNAILNCEVNADLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KPDEGYYQCVATVESLGTIISRTAKLIVAGLPRFTSQPEPSSVYAGNNAILNCEVNADLV
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE1 PFVRWEQNRQPLLLDDRVIKLPSGMLVISNATEGDGGLYRCVVESGGPPKYSDEVELKVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PFVRWEQNRQPLLLDDRVIKLPSGMLVISNATEGDGGLYRCVVESGGPPKYSDEVELKVL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE1 PDPEVISDLVFLKQPSPLVRVIGQDVVLPCVASGLPTPTIKWMKNEEALDTESSERLVLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PDPEVISDLVFLKQPSPLVRVIGQDVVLPCVASGLPTPTIKWMKNEEALDTESSERLVLL
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE1 AGGSLEISDVTEDDAGTYFCIADNGNETIEAQAELTVQAQPEFLKQPTNIYAHESMDIVF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AGGSLEISDVTEDDAGTYFCIADNGNETIEAQAELTVQAQPEFLKQPTNIYAHESMDIVF
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE1 ECEVTGKPTPTVKWVKNGDMVIPSDYFKIVKEHNLQVLGLVKSDEGFYQCIAENDVGNAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ECEVTGKPTPTVKWVKNGDMVIPSDYFKIVKEHNLQVLGLVKSDEGFYQCIAENDVGNAQ
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE1 AGAQLIILEHDVAIPTLPPTSLTSATTDHLAPATTGPLPSAPRDVVASLVSTRFIKLTWR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AGAQLIILEHDVAIPTLPPTSLTSATTDHLAPATTGPLPSAPRDVVASLVSTRFIKLTWR
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE1 TPASDPHGDNLTYSVFYTKEGIARERVENTSHPGEMQVTIQNLMPATVYIFRVMAQNKHG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TPASDPHGDNLTYSVFYTKEGIARERVENTSHPGEMQVTIQNLMPATVYIFRVMAQNKHG
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE1 SGESSAPLRVETQPEVQLPGPAPNLRAYAASPTSITVTWETPVSGNGEIQNYKLYYMEKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SGESSAPLRVETQPEVQLPGPAPNLRAYAASPTSITVTWETPVSGNGEIQNYKLYYMEKG
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE1 TDKEQDVDVSSHSYTINGLKKYTEYSFRVVAYNKHGPGVSTPDVAVRTLSDVPSAAPQNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TDKEQDVDVSSHSYTINGLKKYTEYSFRVVAYNKHGPGVSTPDVAVRTLSDVPSAAPQNL
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE1 SLEVRNSKSIMIHWQPPAPATQNGQITGYKIRYRKASRKSDVTETLVSGTQLSQLIEGLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SLEVRNSKSIMIHWQPPAPATQNGQITGYKIRYRKASRKSDVTETLVSGTQLSQLIEGLD
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE1 RGTEYNFRVAALTINGTGPATDWLSAETFESDLDETRVPEVPSSLHVRPLVTSIVVSWTP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RGTEYNFRVAALTINGTGPATDWLSAETFESDLDETRVPEVPSSLHVRPLVTSIVVSWTP
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE1 PENQNIVVRGYAIGYGIGSPHAQTIKVDYKQRYYTIENLDPSSHYVITLKAFNNVGEGIP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PENQNIVVRGYAIGYGIGSPHAQTIKVDYKQRYYTIENLDPSSHYVITLKAFNNVGEGIP
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE1 LYESAVTRPHTVPDPTPMMPPVGVQASILSHDTIRITWADNSLPKHQKITDSRYYTVRWK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LYESAVTRPHTVPDPTPMMPPVGVQASILSHDTIRITWADNSLPKHQKITDSRYYTVRWK
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE1 TNIPANTKYKNANATTLSYLVTGLKPNTLYEFSVMVTKGRRSSTWSMTAHGTTFELVPTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TNIPANTKYKNANATTLSYLVTGLKPNTLYEFSVMVTKGRRSSTWSMTAHGTTFELVPTS
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE1 PPKDVTVVSKEGKPKTIIVNWQPPSEANGKITGYIIYYSTDVNAEIHDWVIEPVVGNRLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PPKDVTVVSKEGKPKTIIVNWQPPSEANGKITGYIIYYSTDVNAEIHDWVIEPVVGNRLT
970 980 990 1000 1010 1020
1030 1040 1050 1060
pF1KE1 HQIQELTLDTPYYFKIQARNSKGMGPMSEAVQFRTPKA-----------SGSGGKGSRLP
:::::::::::::::::::::::::::::::::::::: :::::::::::
XP_011 HQIQELTLDTPYYFKIQARNSKGMGPMSEAVQFRTPKADSSDKMPNDQASGSGGKGSRLP
1030 1040 1050 1060 1070 1080
1070 1080 1090 1100 1110 1120
pF1KE1 DLGSDYKPPMSGSNSPHGSPTSPLDSNMLLVIIVSVGVITIVVVVIIAVFCTRRTTSHQK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DLGSDYKPPMSGSNSPHGSPTSPLDSNMLLVIIVSVGVITIVVVVIIAVFCTRRTTSHQK
1090 1100 1110 1120 1130 1140
1130 1140 1150 1160 1170 1180
pF1KE1 KKRAACKSVNGSHKYKGNSKDVKPPDLWIHHERLELKPIDKSPDPNPIMTDTPIPRNSQD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KKRAACKSVNGSHKYKGNSKDVKPPDLWIHHERLELKPIDKSPDPNPIMTDTPIPRNSQD
1150 1160 1170 1180 1190 1200
1190 1200 1210 1220 1230 1240
pF1KE1 ITPVDNSMDSNIHQRRNSYRGHESEDSMSTLAGRRGMRPKMMMPFDSQPPQPVISAHPIH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ITPVDNSMDSNIHQRRNSYRGHESEDSMSTLAGRRGMRPKMMMPFDSQPPQPVISAHPIH
1210 1220 1230 1240 1250 1260
1250 1260 1270 1280 1290 1300
pF1KE1 SLDNPHHHFHSSSLASPARSHLYHPGSPWPIGTSMSLSDRANSTESVRNTPSTDTMPASS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SLDNPHHHFHSSSLASPARSHLYHPGSPWPIGTSMSLSDRANSTESVRNTPSTDTMPASS
1270 1280 1290 1300 1310 1320
1310 1320 1330 1340 1350 1360
pF1KE1 SQTCCTDHQDPEGATSSSYLASSQEEDSGQSLPTAHVRPSHPLKSFAVPAIPPPGPPTYD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SQTCCTDHQDPEGATSSSYLASSQEEDSGQSLPTAHVRPSHPLKSFAVPAIPPPGPPTYD
1330 1340 1350 1360 1370 1380
1370 1380 1390 1400 1410 1420
pF1KE1 PALPSTPLLSQQALNHHIHSVKTASIGTLGRSRPPMPVVVPSAPEVQETTRMLEDSESSY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PALPSTPLLSQQALNHHIHSVKTASIGTLGRSRPPMPVVVPSAPEVQETTRMLEDSESSY
1390 1400 1410 1420 1430 1440
1430 1440 1450
pF1KE1 EPDELTKEMAHLEGLMKDLNAITTA
:::::::::::::::::::::::::
XP_011 EPDELTKEMAHLEGLMKDLNAITTA
1450 1460
>>XP_016877723 (OMIM: 601907) PREDICTED: neogenin isofor (1412 aa)
initn: 8243 init1: 6999 opt: 7049 Z-score: 3352.7 bits: 632.9 E(85289): 5.2e-180
Smith-Waterman score: 9159; 95.6% identity (95.6% similar) in 1465 aa overlap (1-1454:1-1412)
10 20 30 40 50 60
pF1KE1 MAAERGARRLLSTPSFWLYCLLLLGRRAPGAAAARSGSAPQSPGASIRTFTPFYFLVEPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MAAERGARRLLSTPSFWLYCLLLLGRRAPGAAAARSGSAPQSPGASIRTFTPFYFLVEPV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 DTLSVRGSSVILNCSAYSEPSPKIEWKKDGTFLNLVSDDRRQLLPDGSLFISNVVHSKHN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DTLSVRGSSVILNCSAYSEPSPKIEWKKDGTFLNLVSDDRRQLLPDGSLFISNVVHSKHN
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 KPDEGYYQCVATVESLGTIISRTAKLIVAGLPRFTSQPEPSSVYAGNNAILNCEVNADLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KPDEGYYQCVATVESLGTIISRTAKLIVAGLPRFTSQPEPSSVYAGNNAILNCEVNADLV
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE1 PFVRWEQNRQPLLLDDRVIKLPSGMLVISNATEGDGGLYRCVVESGGPPKYSDEVELKVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PFVRWEQNRQPLLLDDRVIKLPSGMLVISNATEGDGGLYRCVVESGGPPKYSDEVELKVL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE1 PDPEVISDLVFLKQPSPLVRVIGQDVVLPCVASGLPTPTIKWMKNEEALDTESSERLVLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PDPEVISDLVFLKQPSPLVRVIGQDVVLPCVASGLPTPTIKWMKNEEALDTESSERLVLL
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE1 AGGSLEISDVTEDDAGTYFCIADNGNETIEAQAELTVQAQPEFLKQPTNIYAHESMDIVF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AGGSLEISDVTEDDAGTYFCIADNGNETIEAQAELTVQAQPEFLKQPTNIYAHESMDIVF
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE1 ECEVTGKPTPTVKWVKNGDMVIPSDYFKIVKEHNLQVLGLVKSDEGFYQCIAENDVGNAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ECEVTGKPTPTVKWVKNGDMVIPSDYFKIVKEHNLQVLGLVKSDEGFYQCIAENDVGNAQ
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE1 AGAQLIILEHDVAIPTLPPTSLTSATTDHLAPATTGPLPSAPRDVVASLVSTRFIKLTWR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AGAQLIILEHDVAIPTLPPTSLTSATTDHLAPATTGPLPSAPRDVVASLVSTRFIKLTWR
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE1 TPASDPHGDNLTYSVFYTKEGIARERVENTSHPGEMQVTIQNLMPATVYIFRVMAQNKHG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TPASDPHGDNLTYSVFYTKEGIARERVENTSHPGEMQVTIQNLMPATVYIFRVMAQNKHG
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE1 SGESSAPLRVETQPEVQLPGPAPNLRAYAASPTSITVTWETPVSGNGEIQNYKLYYMEKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SGESSAPLRVETQPEVQLPGPAPNLRAYAASPTSITVTWETPVSGNGEIQNYKLYYMEKG
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE1 TDKEQDVDVSSHSYTINGLKKYTEYSFRVVAYNKHGPGVSTPDVAVRTLSDVPSAAPQNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TDKEQDVDVSSHSYTINGLKKYTEYSFRVVAYNKHGPGVSTPDVAVRTLSDVPSAAPQNL
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE1 SLEVRNSKSIMIHWQPPAPATQNGQITGYKIRYRKASRKSDVTETLVSGTQLSQLIEGLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SLEVRNSKSIMIHWQPPAPATQNGQITGYKIRYRKASRKSDVTETLVSGTQLSQLIEGLD
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE1 RGTEYNFRVAALTINGTGPATDWLSAETFESDLDETRVPEVPSSLHVRPLVTSIVVSWTP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RGTEYNFRVAALTINGTGPATDWLSAETFESDLDETRVPEVPSSLHVRPLVTSIVVSWTP
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE1 PENQNIVVRGYAIGYGIGSPHAQTIKVDYKQRYYTIENLDPSSHYVITLKAFNNVGEGIP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PENQNIVVRGYAIGYGIGSPHAQTIKVDYKQRYYTIENLDPSSHYVITLKAFNNVGEGIP
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE1 LYESAVTRPHTVPDPTPMMPPVGVQASILSHDTIRITWADNSLPKHQKITDSRYYTVRWK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LYESAVTRPHTVPDPTPMMPPVGVQASILSHDTIRITWADNSLPKHQKITDSRYYTVRWK
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE1 TNIPANTKYKNANATTLSYLVTGLKPNTLYEFSVMVTKGRRSSTWSMTAHGTTFELVPTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TNIPANTKYKNANATTLSYLVTGLKPNTLYEFSVMVTKGRRSSTWSMTAHGTTFELVPTS
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE1 PPKDVTVVSKEGKPKTIIVNWQPPSEANGKITGYIIYYSTDVNAEIHDWVIEPVVGNRLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PPKDVTVVSKEGKPKTIIVNWQPPSEANGKITGYIIYYSTDVNAEIHDWVIEPVVGNRLT
970 980 990 1000 1010 1020
1030 1040 1050 1060
pF1KE1 HQIQELTLDTPYYFKIQARNSKGMGPMSEAVQFRTPKA-----------SGSGGKGSRLP
:::::::::::::::::::::::::::::::::::::: :::::::::::
XP_016 HQIQELTLDTPYYFKIQARNSKGMGPMSEAVQFRTPKADSSDKMPNDQASGSGGKGSRLP
1030 1040 1050 1060 1070 1080
1070 1080 1090 1100 1110 1120
pF1KE1 DLGSDYKPPMSGSNSPHGSPTSPLDSNMLLVIIVSVGVITIVVVVIIAVFCTRRTTSHQK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DLGSDYKPPMSGSNSPHGSPTSPLDSNMLLVIIVSVGVITIVVVVIIAVFCTRRTTSHQK
1090 1100 1110 1120 1130 1140
1130 1140 1150 1160 1170 1180
pF1KE1 KKRAACKSVNGSHKYKGNSKDVKPPDLWIHHERLELKPIDKSPDPNPIMTDTPIPRNSQD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KKRAACKSVNGSHKYKGNSKDVKPPDLWIHHERLELKPIDKSPDPNPIMTDTPIPRNSQD
1150 1160 1170 1180 1190 1200
1190 1200 1210 1220 1230 1240
pF1KE1 ITPVDNSMDSNIHQRRNSYRGHESEDSMSTLAGRRGMRPKMMMPFDSQPPQPVISAHPIH
:::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ITPVDNSMDSNIHQRRNSYRGHESEDSMSTLAGRRGMRPKMMMPFDSQPPQ---------
1210 1220 1230 1240 1250
1250 1260 1270 1280 1290 1300
pF1KE1 SLDNPHHHFHSSSLASPARSHLYHPGSPWPIGTSMSLSDRANSTESVRNTPSTDTMPASS
.:::::::::::::::
XP_016 --------------------------------------------QSVRNTPSTDTMPASS
1260
1310 1320 1330 1340 1350 1360
pF1KE1 SQTCCTDHQDPEGATSSSYLASSQEEDSGQSLPTAHVRPSHPLKSFAVPAIPPPGPPTYD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SQTCCTDHQDPEGATSSSYLASSQEEDSGQSLPTAHVRPSHPLKSFAVPAIPPPGPPTYD
1270 1280 1290 1300 1310 1320
1370 1380 1390 1400 1410 1420
pF1KE1 PALPSTPLLSQQALNHHIHSVKTASIGTLGRSRPPMPVVVPSAPEVQETTRMLEDSESSY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PALPSTPLLSQQALNHHIHSVKTASIGTLGRSRPPMPVVVPSAPEVQETTRMLEDSESSY
1330 1340 1350 1360 1370 1380
1430 1440 1450
pF1KE1 EPDELTKEMAHLEGLMKDLNAITTA
:::::::::::::::::::::::::
XP_016 EPDELTKEMAHLEGLMKDLNAITTA
1390 1400 1410
>>NP_002490 (OMIM: 601907) neogenin isoform 1 precursor (1461 aa)
initn: 5728 init1: 2852 opt: 6810 Z-score: 3239.5 bits: 612.0 E(85289): 1.1e-173
Smith-Waterman score: 9439; 96.8% identity (96.8% similar) in 1481 aa overlap (1-1454:1-1461)
10 20 30 40 50 60
pF1KE1 MAAERGARRLLSTPSFWLYCLLLLGRRAPGAAAARSGSAPQSPGASIRTFTPFYFLVEPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 MAAERGARRLLSTPSFWLYCLLLLGRRAPGAAAARSGSAPQSPGASIRTFTPFYFLVEPV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 DTLSVRGSSVILNCSAYSEPSPKIEWKKDGTFLNLVSDDRRQLLPDGSLFISNVVHSKHN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 DTLSVRGSSVILNCSAYSEPSPKIEWKKDGTFLNLVSDDRRQLLPDGSLFISNVVHSKHN
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 KPDEGYYQCVATVESLGTIISRTAKLIVAGLPRFTSQPEPSSVYAGNNAILNCEVNADLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 KPDEGYYQCVATVESLGTIISRTAKLIVAGLPRFTSQPEPSSVYAGNNAILNCEVNADLV
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE1 PFVRWEQNRQPLLLDDRVIKLPSGMLVISNATEGDGGLYRCVVESGGPPKYSDEVELKVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 PFVRWEQNRQPLLLDDRVIKLPSGMLVISNATEGDGGLYRCVVESGGPPKYSDEVELKVL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE1 PDPEVISDLVFLKQPSPLVRVIGQDVVLPCVASGLPTPTIKWMKNEEALDTESSERLVLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 PDPEVISDLVFLKQPSPLVRVIGQDVVLPCVASGLPTPTIKWMKNEEALDTESSERLVLL
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE1 AGGSLEISDVTEDDAGTYFCIADNGNETIEAQAELTVQAQPEFLKQPTNIYAHESMDIVF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 AGGSLEISDVTEDDAGTYFCIADNGNETIEAQAELTVQAQPEFLKQPTNIYAHESMDIVF
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE1 ECEVTGKPTPTVKWVKNGDMVIPSDYFKIVKEHNLQVLGLVKSDEGFYQCIAENDVGNAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 ECEVTGKPTPTVKWVKNGDMVIPSDYFKIVKEHNLQVLGLVKSDEGFYQCIAENDVGNAQ
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE1 AGAQLIILEHDVAIPTLPPTSLTSATTDHLAPATTGPLPSAPRDVVASLVSTRFIKLTWR
:::::::::: ::::::::::::::::::::::::::::::
NP_002 AGAQLIILEH--------------------APATTGPLPSAPRDVVASLVSTRFIKLTWR
430 440 450 460
490 500 510 520 530 540
pF1KE1 TPASDPHGDNLTYSVFYTKEGIARERVENTSHPGEMQVTIQNLMPATVYIFRVMAQNKHG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 TPASDPHGDNLTYSVFYTKEGIARERVENTSHPGEMQVTIQNLMPATVYIFRVMAQNKHG
470 480 490 500 510 520
550 560 570 580 590 600
pF1KE1 SGESSAPLRVETQPEVQLPGPAPNLRAYAASPTSITVTWETPVSGNGEIQNYKLYYMEKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 SGESSAPLRVETQPEVQLPGPAPNLRAYAASPTSITVTWETPVSGNGEIQNYKLYYMEKG
530 540 550 560 570 580
610 620 630 640 650 660
pF1KE1 TDKEQDVDVSSHSYTINGLKKYTEYSFRVVAYNKHGPGVSTPDVAVRTLSDVPSAAPQNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 TDKEQDVDVSSHSYTINGLKKYTEYSFRVVAYNKHGPGVSTPDVAVRTLSDVPSAAPQNL
590 600 610 620 630 640
670 680 690 700 710 720
pF1KE1 SLEVRNSKSIMIHWQPPAPATQNGQITGYKIRYRKASRKSDVTETLVSGTQLSQLIEGLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 SLEVRNSKSIMIHWQPPAPATQNGQITGYKIRYRKASRKSDVTETLVSGTQLSQLIEGLD
650 660 670 680 690 700
730 740 750 760 770 780
pF1KE1 RGTEYNFRVAALTINGTGPATDWLSAETFESDLDETRVPEVPSSLHVRPLVTSIVVSWTP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 RGTEYNFRVAALTINGTGPATDWLSAETFESDLDETRVPEVPSSLHVRPLVTSIVVSWTP
710 720 730 740 750 760
790 800 810 820 830 840
pF1KE1 PENQNIVVRGYAIGYGIGSPHAQTIKVDYKQRYYTIENLDPSSHYVITLKAFNNVGEGIP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 PENQNIVVRGYAIGYGIGSPHAQTIKVDYKQRYYTIENLDPSSHYVITLKAFNNVGEGIP
770 780 790 800 810 820
850 860 870 880
pF1KE1 LYESAVTRPHT----------------VPDPTPMMPPVGVQASILSHDTIRITWADNSLP
::::::::::: :::::::::::::::::::::::::::::::::
NP_002 LYESAVTRPHTDTSEVDLFVINAPYTPVPDPTPMMPPVGVQASILSHDTIRITWADNSLP
830 840 850 860 870 880
890 900 910 920 930 940
pF1KE1 KHQKITDSRYYTVRWKTNIPANTKYKNANATTLSYLVTGLKPNTLYEFSVMVTKGRRSST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 KHQKITDSRYYTVRWKTNIPANTKYKNANATTLSYLVTGLKPNTLYEFSVMVTKGRRSST
890 900 910 920 930 940
950 960 970 980 990 1000
pF1KE1 WSMTAHGTTFELVPTSPPKDVTVVSKEGKPKTIIVNWQPPSEANGKITGYIIYYSTDVNA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 WSMTAHGTTFELVPTSPPKDVTVVSKEGKPKTIIVNWQPPSEANGKITGYIIYYSTDVNA
950 960 970 980 990 1000
1010 1020 1030 1040 1050
pF1KE1 EIHDWVIEPVVGNRLTHQIQELTLDTPYYFKIQARNSKGMGPMSEAVQFRTPKA------
::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 EIHDWVIEPVVGNRLTHQIQELTLDTPYYFKIQARNSKGMGPMSEAVQFRTPKADSSDKM
1010 1020 1030 1040 1050 1060
1060 1070 1080 1090 1100 1110
pF1KE1 -----SGSGGKGSRLPDLGSDYKPPMSGSNSPHGSPTSPLDSNMLLVIIVSVGVITIVVV
:::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 PNDQASGSGGKGSRLPDLGSDYKPPMSGSNSPHGSPTSPLDSNMLLVIIVSVGVITIVVV
1070 1080 1090 1100 1110 1120
1120 1130 1140 1150 1160 1170
pF1KE1 VIIAVFCTRRTTSHQKKKRAACKSVNGSHKYKGNSKDVKPPDLWIHHERLELKPIDKSPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 VIIAVFCTRRTTSHQKKKRAACKSVNGSHKYKGNSKDVKPPDLWIHHERLELKPIDKSPD
1130 1140 1150 1160 1170 1180
1180 1190 1200 1210 1220 1230
pF1KE1 PNPIMTDTPIPRNSQDITPVDNSMDSNIHQRRNSYRGHESEDSMSTLAGRRGMRPKMMMP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 PNPIMTDTPIPRNSQDITPVDNSMDSNIHQRRNSYRGHESEDSMSTLAGRRGMRPKMMMP
1190 1200 1210 1220 1230 1240
1240 1250 1260 1270 1280 1290
pF1KE1 FDSQPPQPVISAHPIHSLDNPHHHFHSSSLASPARSHLYHPGSPWPIGTSMSLSDRANST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 FDSQPPQPVISAHPIHSLDNPHHHFHSSSLASPARSHLYHPGSPWPIGTSMSLSDRANST
1250 1260 1270 1280 1290 1300
1300 1310 1320 1330 1340 1350
pF1KE1 ESVRNTPSTDTMPASSSQTCCTDHQDPEGATSSSYLASSQEEDSGQSLPTAHVRPSHPLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 ESVRNTPSTDTMPASSSQTCCTDHQDPEGATSSSYLASSQEEDSGQSLPTAHVRPSHPLK
1310 1320 1330 1340 1350 1360
1360 1370 1380 1390 1400 1410
pF1KE1 SFAVPAIPPPGPPTYDPALPSTPLLSQQALNHHIHSVKTASIGTLGRSRPPMPVVVPSAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 SFAVPAIPPPGPPTYDPALPSTPLLSQQALNHHIHSVKTASIGTLGRSRPPMPVVVPSAP
1370 1380 1390 1400 1410 1420
1420 1430 1440 1450
pF1KE1 EVQETTRMLEDSESSYEPDELTKEMAHLEGLMKDLNAITTA
:::::::::::::::::::::::::::::::::::::::::
NP_002 EVQETTRMLEDSESSYEPDELTKEMAHLEGLMKDLNAITTA
1430 1440 1450 1460
>>NP_001166095 (OMIM: 601907) neogenin isoform 3 precurs (1450 aa)
initn: 6997 init1: 4078 opt: 6799 Z-score: 3234.3 bits: 611.0 E(85289): 2e-173
Smith-Waterman score: 9471; 97.6% identity (97.6% similar) in 1470 aa overlap (1-1454:1-1450)
10 20 30 40 50 60
pF1KE1 MAAERGARRLLSTPSFWLYCLLLLGRRAPGAAAARSGSAPQSPGASIRTFTPFYFLVEPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MAAERGARRLLSTPSFWLYCLLLLGRRAPGAAAARSGSAPQSPGASIRTFTPFYFLVEPV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 DTLSVRGSSVILNCSAYSEPSPKIEWKKDGTFLNLVSDDRRQLLPDGSLFISNVVHSKHN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DTLSVRGSSVILNCSAYSEPSPKIEWKKDGTFLNLVSDDRRQLLPDGSLFISNVVHSKHN
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 KPDEGYYQCVATVESLGTIISRTAKLIVAGLPRFTSQPEPSSVYAGNNAILNCEVNADLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KPDEGYYQCVATVESLGTIISRTAKLIVAGLPRFTSQPEPSSVYAGNNAILNCEVNADLV
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE1 PFVRWEQNRQPLLLDDRVIKLPSGMLVISNATEGDGGLYRCVVESGGPPKYSDEVELKVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PFVRWEQNRQPLLLDDRVIKLPSGMLVISNATEGDGGLYRCVVESGGPPKYSDEVELKVL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE1 PDPEVISDLVFLKQPSPLVRVIGQDVVLPCVASGLPTPTIKWMKNEEALDTESSERLVLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PDPEVISDLVFLKQPSPLVRVIGQDVVLPCVASGLPTPTIKWMKNEEALDTESSERLVLL
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE1 AGGSLEISDVTEDDAGTYFCIADNGNETIEAQAELTVQAQPEFLKQPTNIYAHESMDIVF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AGGSLEISDVTEDDAGTYFCIADNGNETIEAQAELTVQAQPEFLKQPTNIYAHESMDIVF
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE1 ECEVTGKPTPTVKWVKNGDMVIPSDYFKIVKEHNLQVLGLVKSDEGFYQCIAENDVGNAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ECEVTGKPTPTVKWVKNGDMVIPSDYFKIVKEHNLQVLGLVKSDEGFYQCIAENDVGNAQ
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE1 AGAQLIILEHDVAIPTLPPTSLTSATTDHLAPATTGPLPSAPRDVVASLVSTRFIKLTWR
:::::::::: ::::::::::::::::::::::::::::::
NP_001 AGAQLIILEH--------------------APATTGPLPSAPRDVVASLVSTRFIKLTWR
430 440 450 460
490 500 510 520 530 540
pF1KE1 TPASDPHGDNLTYSVFYTKEGIARERVENTSHPGEMQVTIQNLMPATVYIFRVMAQNKHG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TPASDPHGDNLTYSVFYTKEGIARERVENTSHPGEMQVTIQNLMPATVYIFRVMAQNKHG
470 480 490 500 510 520
550 560 570 580 590 600
pF1KE1 SGESSAPLRVETQPEVQLPGPAPNLRAYAASPTSITVTWETPVSGNGEIQNYKLYYMEKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SGESSAPLRVETQPEVQLPGPAPNLRAYAASPTSITVTWETPVSGNGEIQNYKLYYMEKG
530 540 550 560 570 580
610 620 630 640 650 660
pF1KE1 TDKEQDVDVSSHSYTINGLKKYTEYSFRVVAYNKHGPGVSTPDVAVRTLSDVPSAAPQNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TDKEQDVDVSSHSYTINGLKKYTEYSFRVVAYNKHGPGVSTPDVAVRTLSDVPSAAPQNL
590 600 610 620 630 640
670 680 690 700 710 720
pF1KE1 SLEVRNSKSIMIHWQPPAPATQNGQITGYKIRYRKASRKSDVTETLVSGTQLSQLIEGLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SLEVRNSKSIMIHWQPPAPATQNGQITGYKIRYRKASRKSDVTETLVSGTQLSQLIEGLD
650 660 670 680 690 700
730 740 750 760 770 780
pF1KE1 RGTEYNFRVAALTINGTGPATDWLSAETFESDLDETRVPEVPSSLHVRPLVTSIVVSWTP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RGTEYNFRVAALTINGTGPATDWLSAETFESDLDETRVPEVPSSLHVRPLVTSIVVSWTP
710 720 730 740 750 760
790 800 810 820 830 840
pF1KE1 PENQNIVVRGYAIGYGIGSPHAQTIKVDYKQRYYTIENLDPSSHYVITLKAFNNVGEGIP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PENQNIVVRGYAIGYGIGSPHAQTIKVDYKQRYYTIENLDPSSHYVITLKAFNNVGEGIP
770 780 790 800 810 820
850 860 870 880
pF1KE1 LYESAVTRPHT----------------VPDPTPMMPPVGVQASILSHDTIRITWADNSLP
::::::::::: :::::::::::::::::::::::::::::::::
NP_001 LYESAVTRPHTDTSEVDLFVINAPYTPVPDPTPMMPPVGVQASILSHDTIRITWADNSLP
830 840 850 860 870 880
890 900 910 920 930 940
pF1KE1 KHQKITDSRYYTVRWKTNIPANTKYKNANATTLSYLVTGLKPNTLYEFSVMVTKGRRSST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KHQKITDSRYYTVRWKTNIPANTKYKNANATTLSYLVTGLKPNTLYEFSVMVTKGRRSST
890 900 910 920 930 940
950 960 970 980 990 1000
pF1KE1 WSMTAHGTTFELVPTSPPKDVTVVSKEGKPKTIIVNWQPPSEANGKITGYIIYYSTDVNA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 WSMTAHGTTFELVPTSPPKDVTVVSKEGKPKTIIVNWQPPSEANGKITGYIIYYSTDVNA
950 960 970 980 990 1000
1010 1020 1030 1040 1050 1060
pF1KE1 EIHDWVIEPVVGNRLTHQIQELTLDTPYYFKIQARNSKGMGPMSEAVQFRTPKASGSGGK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EIHDWVIEPVVGNRLTHQIQELTLDTPYYFKIQARNSKGMGPMSEAVQFRTPKASGSGGK
1010 1020 1030 1040 1050 1060
1070 1080 1090 1100 1110 1120
pF1KE1 GSRLPDLGSDYKPPMSGSNSPHGSPTSPLDSNMLLVIIVSVGVITIVVVVIIAVFCTRRT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GSRLPDLGSDYKPPMSGSNSPHGSPTSPLDSNMLLVIIVSVGVITIVVVVIIAVFCTRRT
1070 1080 1090 1100 1110 1120
1130 1140 1150 1160 1170 1180
pF1KE1 TSHQKKKRAACKSVNGSHKYKGNSKDVKPPDLWIHHERLELKPIDKSPDPNPIMTDTPIP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TSHQKKKRAACKSVNGSHKYKGNSKDVKPPDLWIHHERLELKPIDKSPDPNPIMTDTPIP
1130 1140 1150 1160 1170 1180
1190 1200 1210 1220 1230 1240
pF1KE1 RNSQDITPVDNSMDSNIHQRRNSYRGHESEDSMSTLAGRRGMRPKMMMPFDSQPPQPVIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RNSQDITPVDNSMDSNIHQRRNSYRGHESEDSMSTLAGRRGMRPKMMMPFDSQPPQPVIS
1190 1200 1210 1220 1230 1240
1250 1260 1270 1280 1290 1300
pF1KE1 AHPIHSLDNPHHHFHSSSLASPARSHLYHPGSPWPIGTSMSLSDRANSTESVRNTPSTDT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AHPIHSLDNPHHHFHSSSLASPARSHLYHPGSPWPIGTSMSLSDRANSTESVRNTPSTDT
1250 1260 1270 1280 1290 1300
1310 1320 1330 1340 1350 1360
pF1KE1 MPASSSQTCCTDHQDPEGATSSSYLASSQEEDSGQSLPTAHVRPSHPLKSFAVPAIPPPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MPASSSQTCCTDHQDPEGATSSSYLASSQEEDSGQSLPTAHVRPSHPLKSFAVPAIPPPG
1310 1320 1330 1340 1350 1360
1370 1380 1390 1400 1410 1420
pF1KE1 PPTYDPALPSTPLLSQQALNHHIHSVKTASIGTLGRSRPPMPVVVPSAPEVQETTRMLED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PPTYDPALPSTPLLSQQALNHHIHSVKTASIGTLGRSRPPMPVVVPSAPEVQETTRMLED
1370 1380 1390 1400 1410 1420
1430 1440 1450
pF1KE1 SESSYEPDELTKEMAHLEGLMKDLNAITTA
::::::::::::::::::::::::::::::
NP_001 SESSYEPDELTKEMAHLEGLMKDLNAITTA
1430 1440 1450
>>XP_016877720 (OMIM: 601907) PREDICTED: neogenin isofor (1434 aa)
initn: 6712 init1: 6712 opt: 6714 Z-score: 3194.2 bits: 603.6 E(85289): 3.5e-171
Smith-Waterman score: 9513; 98.6% identity (98.6% similar) in 1454 aa overlap (1-1454:1-1434)
10 20 30 40 50 60
pF1KE1 MAAERGARRLLSTPSFWLYCLLLLGRRAPGAAAARSGSAPQSPGASIRTFTPFYFLVEPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MAAERGARRLLSTPSFWLYCLLLLGRRAPGAAAARSGSAPQSPGASIRTFTPFYFLVEPV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 DTLSVRGSSVILNCSAYSEPSPKIEWKKDGTFLNLVSDDRRQLLPDGSLFISNVVHSKHN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DTLSVRGSSVILNCSAYSEPSPKIEWKKDGTFLNLVSDDRRQLLPDGSLFISNVVHSKHN
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 KPDEGYYQCVATVESLGTIISRTAKLIVAGLPRFTSQPEPSSVYAGNNAILNCEVNADLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KPDEGYYQCVATVESLGTIISRTAKLIVAGLPRFTSQPEPSSVYAGNNAILNCEVNADLV
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE1 PFVRWEQNRQPLLLDDRVIKLPSGMLVISNATEGDGGLYRCVVESGGPPKYSDEVELKVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PFVRWEQNRQPLLLDDRVIKLPSGMLVISNATEGDGGLYRCVVESGGPPKYSDEVELKVL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE1 PDPEVISDLVFLKQPSPLVRVIGQDVVLPCVASGLPTPTIKWMKNEEALDTESSERLVLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PDPEVISDLVFLKQPSPLVRVIGQDVVLPCVASGLPTPTIKWMKNEEALDTESSERLVLL
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE1 AGGSLEISDVTEDDAGTYFCIADNGNETIEAQAELTVQAQPEFLKQPTNIYAHESMDIVF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AGGSLEISDVTEDDAGTYFCIADNGNETIEAQAELTVQAQPEFLKQPTNIYAHESMDIVF
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE1 ECEVTGKPTPTVKWVKNGDMVIPSDYFKIVKEHNLQVLGLVKSDEGFYQCIAENDVGNAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ECEVTGKPTPTVKWVKNGDMVIPSDYFKIVKEHNLQVLGLVKSDEGFYQCIAENDVGNAQ
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE1 AGAQLIILEHDVAIPTLPPTSLTSATTDHLAPATTGPLPSAPRDVVASLVSTRFIKLTWR
:::::::::: ::::::::::::::::::::::::::::::
XP_016 AGAQLIILEH--------------------APATTGPLPSAPRDVVASLVSTRFIKLTWR
430 440 450 460
490 500 510 520 530 540
pF1KE1 TPASDPHGDNLTYSVFYTKEGIARERVENTSHPGEMQVTIQNLMPATVYIFRVMAQNKHG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TPASDPHGDNLTYSVFYTKEGIARERVENTSHPGEMQVTIQNLMPATVYIFRVMAQNKHG
470 480 490 500 510 520
550 560 570 580 590 600
pF1KE1 SGESSAPLRVETQPEVQLPGPAPNLRAYAASPTSITVTWETPVSGNGEIQNYKLYYMEKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SGESSAPLRVETQPEVQLPGPAPNLRAYAASPTSITVTWETPVSGNGEIQNYKLYYMEKG
530 540 550 560 570 580
610 620 630 640 650 660
pF1KE1 TDKEQDVDVSSHSYTINGLKKYTEYSFRVVAYNKHGPGVSTPDVAVRTLSDVPSAAPQNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TDKEQDVDVSSHSYTINGLKKYTEYSFRVVAYNKHGPGVSTPDVAVRTLSDVPSAAPQNL
590 600 610 620 630 640
670 680 690 700 710 720
pF1KE1 SLEVRNSKSIMIHWQPPAPATQNGQITGYKIRYRKASRKSDVTETLVSGTQLSQLIEGLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SLEVRNSKSIMIHWQPPAPATQNGQITGYKIRYRKASRKSDVTETLVSGTQLSQLIEGLD
650 660 670 680 690 700
730 740 750 760 770 780
pF1KE1 RGTEYNFRVAALTINGTGPATDWLSAETFESDLDETRVPEVPSSLHVRPLVTSIVVSWTP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RGTEYNFRVAALTINGTGPATDWLSAETFESDLDETRVPEVPSSLHVRPLVTSIVVSWTP
710 720 730 740 750 760
790 800 810 820 830 840
pF1KE1 PENQNIVVRGYAIGYGIGSPHAQTIKVDYKQRYYTIENLDPSSHYVITLKAFNNVGEGIP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PENQNIVVRGYAIGYGIGSPHAQTIKVDYKQRYYTIENLDPSSHYVITLKAFNNVGEGIP
770 780 790 800 810 820
850 860 870 880 890 900
pF1KE1 LYESAVTRPHTVPDPTPMMPPVGVQASILSHDTIRITWADNSLPKHQKITDSRYYTVRWK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LYESAVTRPHTVPDPTPMMPPVGVQASILSHDTIRITWADNSLPKHQKITDSRYYTVRWK
830 840 850 860 870 880
910 920 930 940 950 960
pF1KE1 TNIPANTKYKNANATTLSYLVTGLKPNTLYEFSVMVTKGRRSSTWSMTAHGTTFELVPTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TNIPANTKYKNANATTLSYLVTGLKPNTLYEFSVMVTKGRRSSTWSMTAHGTTFELVPTS
890 900 910 920 930 940
970 980 990 1000 1010 1020
pF1KE1 PPKDVTVVSKEGKPKTIIVNWQPPSEANGKITGYIIYYSTDVNAEIHDWVIEPVVGNRLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PPKDVTVVSKEGKPKTIIVNWQPPSEANGKITGYIIYYSTDVNAEIHDWVIEPVVGNRLT
950 960 970 980 990 1000
1030 1040 1050 1060 1070 1080
pF1KE1 HQIQELTLDTPYYFKIQARNSKGMGPMSEAVQFRTPKASGSGGKGSRLPDLGSDYKPPMS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HQIQELTLDTPYYFKIQARNSKGMGPMSEAVQFRTPKASGSGGKGSRLPDLGSDYKPPMS
1010 1020 1030 1040 1050 1060
1090 1100 1110 1120 1130 1140
pF1KE1 GSNSPHGSPTSPLDSNMLLVIIVSVGVITIVVVVIIAVFCTRRTTSHQKKKRAACKSVNG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GSNSPHGSPTSPLDSNMLLVIIVSVGVITIVVVVIIAVFCTRRTTSHQKKKRAACKSVNG
1070 1080 1090 1100 1110 1120
1150 1160 1170 1180 1190 1200
pF1KE1 SHKYKGNSKDVKPPDLWIHHERLELKPIDKSPDPNPIMTDTPIPRNSQDITPVDNSMDSN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SHKYKGNSKDVKPPDLWIHHERLELKPIDKSPDPNPIMTDTPIPRNSQDITPVDNSMDSN
1130 1140 1150 1160 1170 1180
1210 1220 1230 1240 1250 1260
pF1KE1 IHQRRNSYRGHESEDSMSTLAGRRGMRPKMMMPFDSQPPQPVISAHPIHSLDNPHHHFHS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IHQRRNSYRGHESEDSMSTLAGRRGMRPKMMMPFDSQPPQPVISAHPIHSLDNPHHHFHS
1190 1200 1210 1220 1230 1240
1270 1280 1290 1300 1310 1320
pF1KE1 SSLASPARSHLYHPGSPWPIGTSMSLSDRANSTESVRNTPSTDTMPASSSQTCCTDHQDP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SSLASPARSHLYHPGSPWPIGTSMSLSDRANSTESVRNTPSTDTMPASSSQTCCTDHQDP
1250 1260 1270 1280 1290 1300
1330 1340 1350 1360 1370 1380
pF1KE1 EGATSSSYLASSQEEDSGQSLPTAHVRPSHPLKSFAVPAIPPPGPPTYDPALPSTPLLSQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EGATSSSYLASSQEEDSGQSLPTAHVRPSHPLKSFAVPAIPPPGPPTYDPALPSTPLLSQ
1310 1320 1330 1340 1350 1360
1390 1400 1410 1420 1430 1440
pF1KE1 QALNHHIHSVKTASIGTLGRSRPPMPVVVPSAPEVQETTRMLEDSESSYEPDELTKEMAH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QALNHHIHSVKTASIGTLGRSRPPMPVVVPSAPEVQETTRMLEDSESSYEPDELTKEMAH
1370 1380 1390 1400 1410 1420
1450
pF1KE1 LEGLMKDLNAITTA
::::::::::::::
XP_016 LEGLMKDLNAITTA
1430
>>XP_016877726 (OMIM: 601907) PREDICTED: neogenin isofor (1394 aa)
initn: 8069 init1: 5611 opt: 6677 Z-score: 3176.9 bits: 600.4 E(85289): 3.2e-170
Smith-Waterman score: 8933; 93.7% identity (93.7% similar) in 1470 aa overlap (1-1454:1-1394)
10 20 30 40 50 60
pF1KE1 MAAERGARRLLSTPSFWLYCLLLLGRRAPGAAAARSGSAPQSPGASIRTFTPFYFLVEPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MAAERGARRLLSTPSFWLYCLLLLGRRAPGAAAARSGSAPQSPGASIRTFTPFYFLVEPV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 DTLSVRGSSVILNCSAYSEPSPKIEWKKDGTFLNLVSDDRRQLLPDGSLFISNVVHSKHN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DTLSVRGSSVILNCSAYSEPSPKIEWKKDGTFLNLVSDDRRQLLPDGSLFISNVVHSKHN
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 KPDEGYYQCVATVESLGTIISRTAKLIVAGLPRFTSQPEPSSVYAGNNAILNCEVNADLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KPDEGYYQCVATVESLGTIISRTAKLIVAGLPRFTSQPEPSSVYAGNNAILNCEVNADLV
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE1 PFVRWEQNRQPLLLDDRVIKLPSGMLVISNATEGDGGLYRCVVESGGPPKYSDEVELKVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PFVRWEQNRQPLLLDDRVIKLPSGMLVISNATEGDGGLYRCVVESGGPPKYSDEVELKVL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE1 PDPEVISDLVFLKQPSPLVRVIGQDVVLPCVASGLPTPTIKWMKNEEALDTESSERLVLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PDPEVISDLVFLKQPSPLVRVIGQDVVLPCVASGLPTPTIKWMKNEEALDTESSERLVLL
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE1 AGGSLEISDVTEDDAGTYFCIADNGNETIEAQAELTVQAQPEFLKQPTNIYAHESMDIVF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AGGSLEISDVTEDDAGTYFCIADNGNETIEAQAELTVQAQPEFLKQPTNIYAHESMDIVF
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE1 ECEVTGKPTPTVKWVKNGDMVIPSDYFKIVKEHNLQVLGLVKSDEGFYQCIAENDVGNAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ECEVTGKPTPTVKWVKNGDMVIPSDYFKIVKEHNLQVLGLVKSDEGFYQCIAENDVGNAQ
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE1 AGAQLIILEHDVAIPTLPPTSLTSATTDHLAPATTGPLPSAPRDVVASLVSTRFIKLTWR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AGAQLIILEHDVAIPTLPPTSLTSATTDHLAPATTGPLPSAPRDVVASLVSTRFIKLTWR
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE1 TPASDPHGDNLTYSVFYTKEGIARERVENTSHPGEMQVTIQNLMPATVYIFRVMAQNKHG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TPASDPHGDNLTYSVFYTKEGIARERVENTSHPGEMQVTIQNLMPATVYIFRVMAQNKHG
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE1 SGESSAPLRVETQPEVQLPGPAPNLRAYAASPTSITVTWETPVSGNGEIQNYKLYYMEKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SGESSAPLRVETQPEVQLPGPAPNLRAYAASPTSITVTWETPVSGNGEIQNYKLYYMEKG
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE1 TDKEQDVDVSSHSYTINGLKKYTEYSFRVVAYNKHGPGVSTPDVAVRTLSDVPSAAPQNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TDKEQDVDVSSHSYTINGLKKYTEYSFRVVAYNKHGPGVSTPDVAVRTLSDVPSAAPQNL
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE1 SLEVRNSKSIMIHWQPPAPATQNGQITGYKIRYRKASRKSDVTETLVSGTQLSQLIEGLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SLEVRNSKSIMIHWQPPAPATQNGQITGYKIRYRKASRKSDVTETLVSGTQLSQLIEGLD
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE1 RGTEYNFRVAALTINGTGPATDWLSAETFESDLDETRVPEVPSSLHVRPLVTSIVVSWTP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RGTEYNFRVAALTINGTGPATDWLSAETFESDLDETRVPEVPSSLHVRPLVTSIVVSWTP
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE1 PENQNIVVRGYAIGYGIGSPHAQTIKVDYKQRYYTIENLDPSSHYVITLKAFNNVGEGIP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PENQNIVVRGYAIGYGIGSPHAQTIKVDYKQRYYTIENLDPSSHYVITLKAFNNVGEGIP
790 800 810 820 830 840
850 860 870 880
pF1KE1 LYESAVTRPHT----------------VPDPTPMMPPVGVQASILSHDTIRITWADNSLP
::::::::::: :::::::::::::::::::::::::::::::::
XP_016 LYESAVTRPHTDTSEVDLFVINAPYTPVPDPTPMMPPVGVQASILSHDTIRITWADNSLP
850 860 870 880 890 900
890 900 910 920 930 940
pF1KE1 KHQKITDSRYYTVRWKTNIPANTKYKNANATTLSYLVTGLKPNTLYEFSVMVTKGRRSST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KHQKITDSRYYTVRWKTNIPANTKYKNANATTLSYLVTGLKPNTLYEFSVMVTKGRRSST
910 920 930 940 950 960
950 960 970 980 990 1000
pF1KE1 WSMTAHGTTFELVPTSPPKDVTVVSKEGKPKTIIVNWQPPSEANGKITGYIIYYSTDVNA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 WSMTAHGTTFELVPTSPPKDVTVVSKEGKPKTIIVNWQPPSEANGKITGYIIYYSTDVNA
970 980 990 1000 1010 1020
1010 1020 1030 1040 1050 1060
pF1KE1 EIHDWVIEPVVGNRLTHQIQELTLDTPYYFKIQARNSKGMGPMSEAVQFRTPKASGSGGK
:::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EIHDWVIEPVVGNRLTHQIQELTLDTPYYFKIQARNSKGMGPMSEAVQFRTPK-------
1030 1040 1050 1060 1070
1070 1080 1090 1100 1110 1120
pF1KE1 GSRLPDLGSDYKPPMSGSNSPHGSPTSPLDSNMLLVIIVSVGVITIVVVVIIAVFCTRRT
::::::::::::::::::::::::::::::::::::::::::::
XP_016 ----------------GSNSPHGSPTSPLDSNMLLVIIVSVGVITIVVVVIIAVFCTRRT
1080 1090 1100 1110
1130 1140 1150 1160 1170 1180
pF1KE1 TSHQKKKRAACKSVNGSHKYKGNSKDVKPPDLWIHHERLELKPIDKSPDPNPIMTDTPIP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TSHQKKKRAACKSVNGSHKYKGNSKDVKPPDLWIHHERLELKPIDKSPDPNPIMTDTPIP
1120 1130 1140 1150 1160 1170
1190 1200 1210 1220 1230 1240
pF1KE1 RNSQDITPVDNSMDSNIHQRRNSYRGHESEDSMSTLAGRRGMRPKMMMPFDSQPPQPVIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RNSQDITPVDNSMDSNIHQRRNSYRGHESEDSMSTLAGRRGMRPKMMMPFDSQPPQ----
1180 1190 1200 1210 1220 1230
1250 1260 1270 1280 1290 1300
pF1KE1 AHPIHSLDNPHHHFHSSSLASPARSHLYHPGSPWPIGTSMSLSDRANSTESVRNTPSTDT
.::::::::::
XP_016 -------------------------------------------------QSVRNTPSTDT
1240
1310 1320 1330 1340 1350 1360
pF1KE1 MPASSSQTCCTDHQDPEGATSSSYLASSQEEDSGQSLPTAHVRPSHPLKSFAVPAIPPPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MPASSSQTCCTDHQDPEGATSSSYLASSQEEDSGQSLPTAHVRPSHPLKSFAVPAIPPPG
1250 1260 1270 1280 1290 1300
1370 1380 1390 1400 1410 1420
pF1KE1 PPTYDPALPSTPLLSQQALNHHIHSVKTASIGTLGRSRPPMPVVVPSAPEVQETTRMLED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PPTYDPALPSTPLLSQQALNHHIHSVKTASIGTLGRSRPPMPVVVPSAPEVQETTRMLED
1310 1320 1330 1340 1350 1360
1430 1440 1450
pF1KE1 SESSYEPDELTKEMAHLEGLMKDLNAITTA
::::::::::::::::::::::::::::::
XP_016 SESSYEPDELTKEMAHLEGLMKDLNAITTA
1370 1380 1390
>>XP_016877722 (OMIM: 601907) PREDICTED: neogenin isofor (1417 aa)
initn: 8233 init1: 5611 opt: 5637 Z-score: 2685.2 bits: 509.4 E(85289): 7.9e-143
Smith-Waterman score: 9149; 95.2% identity (95.3% similar) in 1470 aa overlap (1-1454:1-1417)
10 20 30 40 50 60
pF1KE1 MAAERGARRLLSTPSFWLYCLLLLGRRAPGAAAARSGSAPQSPGASIRTFTPFYFLVEPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MAAERGARRLLSTPSFWLYCLLLLGRRAPGAAAARSGSAPQSPGASIRTFTPFYFLVEPV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 DTLSVRGSSVILNCSAYSEPSPKIEWKKDGTFLNLVSDDRRQLLPDGSLFISNVVHSKHN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DTLSVRGSSVILNCSAYSEPSPKIEWKKDGTFLNLVSDDRRQLLPDGSLFISNVVHSKHN
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 KPDEGYYQCVATVESLGTIISRTAKLIVAGLPRFTSQPEPSSVYAGNNAILNCEVNADLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KPDEGYYQCVATVESLGTIISRTAKLIVAGLPRFTSQPEPSSVYAGNNAILNCEVNADLV
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE1 PFVRWEQNRQPLLLDDRVIKLPSGMLVISNATEGDGGLYRCVVESGGPPKYSDEVELKVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PFVRWEQNRQPLLLDDRVIKLPSGMLVISNATEGDGGLYRCVVESGGPPKYSDEVELKVL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE1 PDPEVISDLVFLKQPSPLVRVIGQDVVLPCVASGLPTPTIKWMKNEEALDTESSERLVLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PDPEVISDLVFLKQPSPLVRVIGQDVVLPCVASGLPTPTIKWMKNEEALDTESSERLVLL
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE1 AGGSLEISDVTEDDAGTYFCIADNGNETIEAQAELTVQAQPEFLKQPTNIYAHESMDIVF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AGGSLEISDVTEDDAGTYFCIADNGNETIEAQAELTVQAQPEFLKQPTNIYAHESMDIVF
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE1 ECEVTGKPTPTVKWVKNGDMVIPSDYFKIVKEHNLQVLGLVKSDEGFYQCIAENDVGNAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ECEVTGKPTPTVKWVKNGDMVIPSDYFKIVKEHNLQVLGLVKSDEGFYQCIAENDVGNAQ
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE1 AGAQLIILEHDVAIPTLPPTSLTSATTDHLAPATTGPLPSAPRDVVASLVSTRFIKLTWR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AGAQLIILEHDVAIPTLPPTSLTSATTDHLAPATTGPLPSAPRDVVASLVSTRFIKLTWR
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE1 TPASDPHGDNLTYSVFYTKEGIARERVENTSHPGEMQVTIQNLMPATVYIFRVMAQNKHG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TPASDPHGDNLTYSVFYTKEGIARERVENTSHPGEMQVTIQNLMPATVYIFRVMAQNKHG
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE1 SGESSAPLRVETQPEVQLPGPAPNLRAYAASPTSITVTWETPVSGNGEIQNYKLYYMEKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SGESSAPLRVETQPEVQLPGPAPNLRAYAASPTSITVTWETPVSGNGEIQNYKLYYMEKG
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE1 TDKEQDVDVSSHSYTINGLKKYTEYSFRVVAYNKHGPGVSTPDVAVRTLSDVPSAAPQNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TDKEQDVDVSSHSYTINGLKKYTEYSFRVVAYNKHGPGVSTPDVAVRTLSDVPSAAPQNL
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE1 SLEVRNSKSIMIHWQPPAPATQNGQITGYKIRYRKASRKSDVTETLVSGTQLSQLIEGLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SLEVRNSKSIMIHWQPPAPATQNGQITGYKIRYRKASRKSDVTETLVSGTQLSQLIEGLD
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE1 RGTEYNFRVAALTINGTGPATDWLSAETFESDLDETRVPEVPSSLHVRPLVTSIVVSWTP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RGTEYNFRVAALTINGTGPATDWLSAETFESDLDETRVPEVPSSLHVRPLVTSIVVSWTP
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE1 PENQNIVVRGYAIGYGIGSPHAQTIKVDYKQRYYTIENLDPSSHYVITLKAFNNVGEGIP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PENQNIVVRGYAIGYGIGSPHAQTIKVDYKQRYYTIENLDPSSHYVITLKAFNNVGEGIP
790 800 810 820 830 840
850 860 870 880
pF1KE1 LYESAVTRPHT----------------VPDPTPMMPPVGVQASILSHDTIRITWADNSLP
::::::::::: :::::::::::::::::::::::::::::::::
XP_016 LYESAVTRPHTDTSEVDLFVINAPYTPVPDPTPMMPPVGVQASILSHDTIRITWADNSLP
850 860 870 880 890 900
890 900 910 920 930 940
pF1KE1 KHQKITDSRYYTVRWKTNIPANTKYKNANATTLSYLVTGLKPNTLYEFSVMVTKGRRSST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KHQKITDSRYYTVRWKTNIPANTKYKNANATTLSYLVTGLKPNTLYEFSVMVTKGRRSST
910 920 930 940 950 960
950 960 970 980 990 1000
pF1KE1 WSMTAHGTTFELVPTSPPKDVTVVSKEGKPKTIIVNWQPPSEANGKITGYIIYYSTDVNA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 WSMTAHGTTFELVPTSPPKDVTVVSKEGKPKTIIVNWQPPSEANGKITGYIIYYSTDVNA
970 980 990 1000 1010 1020
1010 1020 1030 1040 1050 1060
pF1KE1 EIHDWVIEPVVGNRLTHQIQELTLDTPYYFKIQARNSKGMGPMSEAVQFRTPKASGSGGK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EIHDWVIEPVVGNRLTHQIQELTLDTPYYFKIQARNSKGMGPMSEAVQFRTPKASGSGGK
1030 1040 1050 1060 1070 1080
1070 1080 1090 1100 1110 1120
pF1KE1 GSRLPDLGSDYKPPMSGSNSPHGSPTSPLDSNMLLVIIVSVGVITIVVVVIIAVFCTRRT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GSRLPDLGSDYKPPMSGSNSPHGSPTSPLDSNMLLVIIVSVGVITIVVVVIIAVFCTRRT
1090 1100 1110 1120 1130 1140
1130 1140 1150 1160 1170 1180
pF1KE1 TSHQKKKRAACKSVNGSHKYKGNSKDVKPPDLWIHHERLELKPIDKSPDPNPIMTDTPIP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TSHQKKKRAACKSVNGSHKYKGNSKDVKPPDLWIHHERLELKPIDKSPDPNPIMTDTPIP
1150 1160 1170 1180 1190 1200
1190 1200 1210 1220 1230 1240
pF1KE1 RNSQDITPVDNSMDSNIHQRRNSYRGHESEDSMSTLAGRRGMRPKMMMPFDSQPPQPVIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RNSQDITPVDNSMDSNIHQRRNSYRGHESEDSMSTLAGRRGMRPKMMMPFDSQPPQ----
1210 1220 1230 1240 1250
1250 1260 1270 1280 1290 1300
pF1KE1 AHPIHSLDNPHHHFHSSSLASPARSHLYHPGSPWPIGTSMSLSDRANSTESVRNTPSTDT
.::::::::::
XP_016 -------------------------------------------------QSVRNTPSTDT
1260
1310 1320 1330 1340 1350 1360
pF1KE1 MPASSSQTCCTDHQDPEGATSSSYLASSQEEDSGQSLPTAHVRPSHPLKSFAVPAIPPPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MPASSSQTCCTDHQDPEGATSSSYLASSQEEDSGQSLPTAHVRPSHPLKSFAVPAIPPPG
1270 1280 1290 1300 1310 1320
1370 1380 1390 1400 1410 1420
pF1KE1 PPTYDPALPSTPLLSQQALNHHIHSVKTASIGTLGRSRPPMPVVVPSAPEVQETTRMLED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PPTYDPALPSTPLLSQQALNHHIHSVKTASIGTLGRSRPPMPVVVPSAPEVQETTRMLED
1330 1340 1350 1360 1370 1380
1430 1440 1450
pF1KE1 SESSYEPDELTKEMAHLEGLMKDLNAITTA
::::::::::::::::::::::::::::::
XP_016 SESSYEPDELTKEMAHLEGLMKDLNAITTA
1390 1400 1410
1454 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 23:42:29 2016 done: Sun Nov 6 23:42:32 2016
Total Scan time: 19.480 Total Display time: 0.840
Function used was FASTA [36.3.4 Apr, 2011]