Result of FASTA (omim) for pFN21AE4588
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KE4588, 913 aa
  1>>>pF1KE4588 913 - 913 aa - 913 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 9.4682+/-0.000433; mu= 1.1909+/- 0.027
 mean_var=172.5482+/-35.958, 0's: 0 Z-trim(116.5): 52  B-trim: 1718 in 2/55
 Lambda= 0.097638
 statistics sampled from 27586 (27638) to 27586 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.653), E-opt: 0.2 (0.324), width:  16
 Scan time: 13.040

The best scores are:                                      opt bits E(85289)
NP_003579 (OMIM: 300304,300354) cullin-4B isoform  ( 913) 5859 838.2       0
XP_005262538 (OMIM: 300304,300354) PREDICTED: cull ( 915) 5845 836.2       0
NP_001073341 (OMIM: 300304,300354) cullin-4B isofo ( 895) 5715 817.9       0
NP_001317553 (OMIM: 300304,300354) cullin-4B isofo ( 900) 5715 817.9       0
XP_006724847 (OMIM: 300304,300354) PREDICTED: cull ( 902) 5701 815.9       0
XP_011529702 (OMIM: 300304,300354) PREDICTED: cull ( 717) 4620 663.6 9.5e-190
XP_011529701 (OMIM: 300304,300354) PREDICTED: cull ( 719) 4606 661.7 3.7e-189
XP_011529703 (OMIM: 300304,300354) PREDICTED: cull ( 701) 4346 625.0 3.9e-178
NP_001008895 (OMIM: 603137) cullin-4A isoform 1 [H ( 759) 4103 590.8 8.4e-168
NP_003580 (OMIM: 603137) cullin-4A isoform 2 [Homo ( 659) 3755 541.8 4.2e-153
NP_001265442 (OMIM: 603137) cullin-4A isoform 2 [H ( 659) 3755 541.8 4.2e-153
XP_011535825 (OMIM: 603137) PREDICTED: cullin-4A i ( 659) 3755 541.8 4.2e-153
NP_001265443 (OMIM: 603137) cullin-4A isoform 3 [H ( 667) 3711 535.6 3.1e-151
NP_001311305 (OMIM: 603135) cullin-2 isoform e [Ho ( 614)  979 150.7   2e-35
NP_001311304 (OMIM: 603135) cullin-2 isoform d [Ho ( 682)  979 150.7 2.2e-35
XP_011518049 (OMIM: 603135) PREDICTED: cullin-2 is ( 745)  979 150.7 2.4e-35
NP_003582 (OMIM: 603135) cullin-2 isoform c [Homo  ( 745)  979 150.7 2.4e-35
NP_001185706 (OMIM: 603135) cullin-2 isoform c [Ho ( 745)  979 150.7 2.4e-35
NP_001185708 (OMIM: 603135) cullin-2 isoform b [Ho ( 758)  979 150.8 2.5e-35
NP_001185707 (OMIM: 603135) cullin-2 isoform a [Ho ( 764)  979 150.8 2.5e-35
XP_011518046 (OMIM: 603135) PREDICTED: cullin-2 is ( 808)  979 150.8 2.6e-35
XP_011518045 (OMIM: 603135) PREDICTED: cullin-2 is ( 808)  979 150.8 2.6e-35
XP_011518047 (OMIM: 603135) PREDICTED: cullin-2 is ( 808)  979 150.8 2.6e-35
NP_003581 (OMIM: 603136,614496) cullin-3 isoform 1 ( 768)  977 150.5   3e-35
XP_011510297 (OMIM: 603136,614496) PREDICTED: cull ( 754)  972 149.8 4.8e-35
XP_006712863 (OMIM: 603136,614496) PREDICTED: cull ( 757)  972 149.8 4.9e-35
NP_001244127 (OMIM: 603136,614496) cullin-3 isofor ( 774)  972 149.8   5e-35
NP_001244126 (OMIM: 603136,614496) cullin-3 isofor ( 702)  888 137.9 1.7e-31
XP_011510298 (OMIM: 603136,614496) PREDICTED: cull ( 704)  888 137.9 1.7e-31
XP_011510296 (OMIM: 603136,614496) PREDICTED: cull ( 719)  888 137.9 1.7e-31
XP_011514933 (OMIM: 603134) PREDICTED: cullin-1 is ( 776)  872 135.7 8.6e-31
XP_005250117 (OMIM: 603134) PREDICTED: cullin-1 is ( 776)  872 135.7 8.6e-31
XP_011514934 (OMIM: 603134) PREDICTED: cullin-1 is ( 776)  872 135.7 8.6e-31
XP_011514931 (OMIM: 603134) PREDICTED: cullin-1 is ( 776)  872 135.7 8.6e-31
XP_011514932 (OMIM: 603134) PREDICTED: cullin-1 is ( 776)  872 135.7 8.6e-31
NP_003583 (OMIM: 603134) cullin-1 [Homo sapiens]   ( 776)  872 135.7 8.6e-31
XP_016868212 (OMIM: 603134) PREDICTED: cullin-1 is ( 455)  839 131.0 1.3e-29
XP_016873854 (OMIM: 601741) PREDICTED: cullin-5 is ( 519)  440 74.8 1.2e-12
XP_016873853 (OMIM: 601741) PREDICTED: cullin-5 is ( 519)  440 74.8 1.2e-12
XP_005271739 (OMIM: 601741) PREDICTED: cullin-5 is ( 721)  288 53.4 4.7e-06
XP_016873852 (OMIM: 601741) PREDICTED: cullin-5 is ( 742)  288 53.4 4.8e-06
NP_003469 (OMIM: 601741) cullin-5 [Homo sapiens]   ( 780)  288 53.4   5e-06
XP_011541315 (OMIM: 601741) PREDICTED: cullin-5 is ( 396)  260 49.4 4.1e-05
NP_037498 (OMIM: 606946) anaphase-promoting comple ( 822)  226 44.7  0.0023


>>NP_003579 (OMIM: 300304,300354) cullin-4B isoform 1 [H  (913 aa)
 initn: 5859 init1: 5859 opt: 5859  Z-score: 4469.1  bits: 838.2 E(85289):    0
Smith-Waterman score: 5859; 99.9% identity (100.0% similar) in 913 aa overlap (1-913:1-913)

               10        20        30        40        50        60
pF1KE4 MMSQSSGSGDGNDDEATTSKDGGFSSPSPSAAAAAQEVRSATDGNTSTTPPTSAKKRKLN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 MMSQSSGSGDGNDDEATTSKDGGFSSPSPSAAAAAQEVRSATDGNTSTTPPTSAKKRKLN
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE4 SSSSSSSNSSNEREDFDSTSSSSSTPPLQPRDSASPSTSSFCLGVSVAASSHVPIQKKLR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 SSSSSSSNSSNEREDFDSTSSSSSTPPLQPRDSASPSTSSFCLGVSVAASSHVPIQKKLR
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KE4 FEDTLEFVGFDAKMAEESSSSSSSSSPTAATSQQQQLKNKSILISSVASVHHANGLAKSS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 FEDTLEFVGFDAKMAEESSSSSSSSSPTAATSQQQQLKNKSILISSVASVHHANGLAKSS
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KE4 TTVSSFANSKPGSAKKLVIKNFKDKPKLPENYTDETWQKLKEAVEAIQNSTSIKYNLEEL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 TTVSSFANSKPGSAKKLVIKNFKDKPKLPENYTDETWQKLKEAVEAIQNSTSIKYNLEEL
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KE4 YQAVENLCSYKISANLYKQLRQICEDHIKAQIHQFREDSLDSVLFLKKIDRCWQNHCRQM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 YQAVENLCSYKISANLYKQLRQICEDHIKAQIHQFREDSLDSVLFLKKIDRCWQNHCRQM
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KE4 IMIRSIFLFLDRTYVLQNSMLPSIWDMGLELFRAHIISDQKVQNKTIDGILLLIERERNG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 IMIRSIFLFLDRTYVLQNSMLPSIWDMGLELFRAHIISDQKVQNKTIDGILLLIERERNG
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KE4 EAIDRSLLRSLLSMLSDLQIYQDSFEQRFLEETNRLYAAEGQKLMQEREVPEYLHHVNKR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 EAIDRSLLRSLLSMLSDLQIYQDSFEQRFLEETNRLYAAEGQKLMQEREVPEYLHHVNKR
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KE4 LEEEADRLITYLDQTTQKSLIATVEKQLLGEHLTAILQKGLNNLLDENRIQDLSLLYQLF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 LEEEADRLITYLDQTTQKSLIATVEKQLLGEHLTAILQKGLNNLLDENRIQDLSLLYQLF
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KE4 SRVRGGVQVLLQQWIEYIKAFGSTIVINPEKDKTMVQELLDFKDKVDHIIDICFLKNEKF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 SRVRGGVQVLLQQWIEYIKAFGSTIVINPEKDKTMVQELLDFKDKVDHIIDICFLKNEKF
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KE4 INAMKEAFETFINKRPNKPAELIAKYVDSKLRAGNKEATDEELEKMLDKIMIIFRFIYGK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 INAMKEAFETFINKRPNKPAELIAKYVDSKLRAGNKEATDEELEKMLDKIMIIFRFIYGK
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KE4 DVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 DVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMI
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KE4 QFKQYMQNQNVPGNIELTVNILTMGYWPTYVPMEVHLPPEMVKLQEIFKTFYLGKHSGRK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 QFKQYMQNQNVPGNIELTVNILTMGYWPTYVPMEVHLPPEMVKLQEIFKTFYLGKHSGRK
              670       680       690       700       710       720

              730       740       750       760       770       780
pF1KE4 LQWQSTIGHCVLKAEFKEGKKELQVSLFQTLVLLMFNEGEEFSLEEIKQATGIEDGELRR
       ::::::.:::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 LQWQSTLGHCVLKAEFKEGKKELQVSLFQTLVLLMFNEGEEFSLEEIKQATGIEDGELRR
              730       740       750       760       770       780

              790       800       810       820       830       840
pF1KE4 TLQSLACGKARVLAKNPKGKDIEDGDKFICNDDFKHKLFRIKINQIQMKETVEEQASTTE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 TLQSLACGKARVLAKNPKGKDIEDGDKFICNDDFKHKLFRIKINQIQMKETVEEQASTTE
              790       800       810       820       830       840

              850       860       870       880       890       900
pF1KE4 RVFQDRQYQIDAAIVRIMKMRKTLSHNLLVSEVYNQLKFPVKPADLKKRIESLIDRDYME
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 RVFQDRQYQIDAAIVRIMKMRKTLSHNLLVSEVYNQLKFPVKPADLKKRIESLIDRDYME
              850       860       870       880       890       900

              910   
pF1KE4 RDKENPNQYNYIA
       :::::::::::::
NP_003 RDKENPNQYNYIA
              910   

>>XP_005262538 (OMIM: 300304,300354) PREDICTED: cullin-4  (915 aa)
 initn: 4229 init1: 4229 opt: 5845  Z-score: 4458.4  bits: 836.2 E(85289):    0
Smith-Waterman score: 5845; 99.7% identity (99.8% similar) in 915 aa overlap (1-913:1-915)

               10        20        30        40        50        60
pF1KE4 MMSQSSGSGDGNDDEATTSKDGGFSSPSPSAAAAAQEVRSATDGNTSTTPPTSAKKRKLN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MMSQSSGSGDGNDDEATTSKDGGFSSPSPSAAAAAQEVRSATDGNTSTTPPTSAKKRKLN
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE4 SSSSSSSNSSNEREDFDSTSSSSSTPPLQPRDSASPSTSSFCLGVSVAASSHVPIQKKLR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SSSSSSSNSSNEREDFDSTSSSSSTPPLQPRDSASPSTSSFCLGVSVAASSHVPIQKKLR
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KE4 FEDTLEFVGFDAKMAEESSSSSSSSSPTAATSQQQQLKNKSILISSVASVHHANGLAKSS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FEDTLEFVGFDAKMAEESSSSSSSSSPTAATSQQQQLKNKSILISSVASVHHANGLAKSS
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KE4 TTVSSFANSKPGSAKKLVIKNFKDKPKLPENYTDETWQKLKEAVEAIQNSTSIKYNLEEL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TTVSSFANSKPGSAKKLVIKNFKDKPKLPENYTDETWQKLKEAVEAIQNSTSIKYNLEEL
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KE4 YQAVENLCSYKISANLYKQLRQICEDHIKAQIHQFREDSLDSVLFLKKIDRCWQNHCRQM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 YQAVENLCSYKISANLYKQLRQICEDHIKAQIHQFREDSLDSVLFLKKIDRCWQNHCRQM
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KE4 IMIRSIFLFLDRTYVLQNSMLPSIWDMGLELFRAHIISDQKVQNKTIDGILLLIERERNG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 IMIRSIFLFLDRTYVLQNSMLPSIWDMGLELFRAHIISDQKVQNKTIDGILLLIERERNG
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KE4 EAIDRSLLRSLLSMLSDLQIYQDSFEQRFLEETNRLYAAEGQKLMQEREVPEYLHHVNKR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EAIDRSLLRSLLSMLSDLQIYQDSFEQRFLEETNRLYAAEGQKLMQEREVPEYLHHVNKR
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KE4 LEEEADRLITYLDQTTQKSLIATVEKQLLGEHLTAILQKGLNNLLDENRIQDLSLLYQLF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LEEEADRLITYLDQTTQKSLIATVEKQLLGEHLTAILQKGLNNLLDENRIQDLSLLYQLF
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KE4 SRVRGGVQVLLQQWIEYIKAFGSTIVINPEKDKTMVQELLDFKDKVDHIIDICFLKNEKF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SRVRGGVQVLLQQWIEYIKAFGSTIVINPEKDKTMVQELLDFKDKVDHIIDICFLKNEKF
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KE4 INAMKEAFETFINKRPNKPAELIAKYVDSKLRAGNKEATDEELEKMLDKIMIIFRFIYGK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 INAMKEAFETFINKRPNKPAELIAKYVDSKLRAGNKEATDEELEKMLDKIMIIFRFIYGK
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KE4 DVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMI
              610       620       630       640       650       660

                670       680       690       700       710        
pF1KE4 QFKQ--YMQNQNVPGNIELTVNILTMGYWPTYVPMEVHLPPEMVKLQEIFKTFYLGKHSG
       ::::  ::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QFKQVKYMQNQNVPGNIELTVNILTMGYWPTYVPMEVHLPPEMVKLQEIFKTFYLGKHSG
              670       680       690       700       710       720

      720       730       740       750       760       770        
pF1KE4 RKLQWQSTIGHCVLKAEFKEGKKELQVSLFQTLVLLMFNEGEEFSLEEIKQATGIEDGEL
       ::::::::.:::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RKLQWQSTLGHCVLKAEFKEGKKELQVSLFQTLVLLMFNEGEEFSLEEIKQATGIEDGEL
              730       740       750       760       770       780

      780       790       800       810       820       830        
pF1KE4 RRTLQSLACGKARVLAKNPKGKDIEDGDKFICNDDFKHKLFRIKINQIQMKETVEEQAST
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RRTLQSLACGKARVLAKNPKGKDIEDGDKFICNDDFKHKLFRIKINQIQMKETVEEQAST
              790       800       810       820       830       840

      840       850       860       870       880       890        
pF1KE4 TERVFQDRQYQIDAAIVRIMKMRKTLSHNLLVSEVYNQLKFPVKPADLKKRIESLIDRDY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TERVFQDRQYQIDAAIVRIMKMRKTLSHNLLVSEVYNQLKFPVKPADLKKRIESLIDRDY
              850       860       870       880       890       900

      900       910   
pF1KE4 MERDKENPNQYNYIA
       :::::::::::::::
XP_005 MERDKENPNQYNYIA
              910     

>>NP_001073341 (OMIM: 300304,300354) cullin-4B isoform 2  (895 aa)
 initn: 5715 init1: 5715 opt: 5715  Z-score: 4359.6  bits: 817.9 E(85289):    0
Smith-Waterman score: 5715; 99.9% identity (100.0% similar) in 891 aa overlap (23-913:5-895)

               10        20        30        40        50        60
pF1KE4 MMSQSSGSGDGNDDEATTSKDGGFSSPSPSAAAAAQEVRSATDGNTSTTPPTSAKKRKLN
                             ::::::::::::::::::::::::::::::::::::::
NP_001                   MFPTGFSSPSPSAAAAAQEVRSATDGNTSTTPPTSAKKRKLN
                                 10        20        30        40  

               70        80        90       100       110       120
pF1KE4 SSSSSSSNSSNEREDFDSTSSSSSTPPLQPRDSASPSTSSFCLGVSVAASSHVPIQKKLR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SSSSSSSNSSNEREDFDSTSSSSSTPPLQPRDSASPSTSSFCLGVSVAASSHVPIQKKLR
             50        60        70        80        90       100  

              130       140       150       160       170       180
pF1KE4 FEDTLEFVGFDAKMAEESSSSSSSSSPTAATSQQQQLKNKSILISSVASVHHANGLAKSS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FEDTLEFVGFDAKMAEESSSSSSSSSPTAATSQQQQLKNKSILISSVASVHHANGLAKSS
            110       120       130       140       150       160  

              190       200       210       220       230       240
pF1KE4 TTVSSFANSKPGSAKKLVIKNFKDKPKLPENYTDETWQKLKEAVEAIQNSTSIKYNLEEL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TTVSSFANSKPGSAKKLVIKNFKDKPKLPENYTDETWQKLKEAVEAIQNSTSIKYNLEEL
            170       180       190       200       210       220  

              250       260       270       280       290       300
pF1KE4 YQAVENLCSYKISANLYKQLRQICEDHIKAQIHQFREDSLDSVLFLKKIDRCWQNHCRQM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YQAVENLCSYKISANLYKQLRQICEDHIKAQIHQFREDSLDSVLFLKKIDRCWQNHCRQM
            230       240       250       260       270       280  

              310       320       330       340       350       360
pF1KE4 IMIRSIFLFLDRTYVLQNSMLPSIWDMGLELFRAHIISDQKVQNKTIDGILLLIERERNG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IMIRSIFLFLDRTYVLQNSMLPSIWDMGLELFRAHIISDQKVQNKTIDGILLLIERERNG
            290       300       310       320       330       340  

              370       380       390       400       410       420
pF1KE4 EAIDRSLLRSLLSMLSDLQIYQDSFEQRFLEETNRLYAAEGQKLMQEREVPEYLHHVNKR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EAIDRSLLRSLLSMLSDLQIYQDSFEQRFLEETNRLYAAEGQKLMQEREVPEYLHHVNKR
            350       360       370       380       390       400  

              430       440       450       460       470       480
pF1KE4 LEEEADRLITYLDQTTQKSLIATVEKQLLGEHLTAILQKGLNNLLDENRIQDLSLLYQLF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LEEEADRLITYLDQTTQKSLIATVEKQLLGEHLTAILQKGLNNLLDENRIQDLSLLYQLF
            410       420       430       440       450       460  

              490       500       510       520       530       540
pF1KE4 SRVRGGVQVLLQQWIEYIKAFGSTIVINPEKDKTMVQELLDFKDKVDHIIDICFLKNEKF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SRVRGGVQVLLQQWIEYIKAFGSTIVINPEKDKTMVQELLDFKDKVDHIIDICFLKNEKF
            470       480       490       500       510       520  

              550       560       570       580       590       600
pF1KE4 INAMKEAFETFINKRPNKPAELIAKYVDSKLRAGNKEATDEELEKMLDKIMIIFRFIYGK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 INAMKEAFETFINKRPNKPAELIAKYVDSKLRAGNKEATDEELEKMLDKIMIIFRFIYGK
            530       540       550       560       570       580  

              610       620       630       640       650       660
pF1KE4 DVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMI
            590       600       610       620       630       640  

              670       680       690       700       710       720
pF1KE4 QFKQYMQNQNVPGNIELTVNILTMGYWPTYVPMEVHLPPEMVKLQEIFKTFYLGKHSGRK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QFKQYMQNQNVPGNIELTVNILTMGYWPTYVPMEVHLPPEMVKLQEIFKTFYLGKHSGRK
            650       660       670       680       690       700  

              730       740       750       760       770       780
pF1KE4 LQWQSTIGHCVLKAEFKEGKKELQVSLFQTLVLLMFNEGEEFSLEEIKQATGIEDGELRR
       ::::::.:::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LQWQSTLGHCVLKAEFKEGKKELQVSLFQTLVLLMFNEGEEFSLEEIKQATGIEDGELRR
            710       720       730       740       750       760  

              790       800       810       820       830       840
pF1KE4 TLQSLACGKARVLAKNPKGKDIEDGDKFICNDDFKHKLFRIKINQIQMKETVEEQASTTE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TLQSLACGKARVLAKNPKGKDIEDGDKFICNDDFKHKLFRIKINQIQMKETVEEQASTTE
            770       780       790       800       810       820  

              850       860       870       880       890       900
pF1KE4 RVFQDRQYQIDAAIVRIMKMRKTLSHNLLVSEVYNQLKFPVKPADLKKRIESLIDRDYME
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RVFQDRQYQIDAAIVRIMKMRKTLSHNLLVSEVYNQLKFPVKPADLKKRIESLIDRDYME
            830       840       850       860       870       880  

              910   
pF1KE4 RDKENPNQYNYIA
       :::::::::::::
NP_001 RDKENPNQYNYIA
            890     

>>NP_001317553 (OMIM: 300304,300354) cullin-4B isoform 3  (900 aa)
 initn: 5715 init1: 5715 opt: 5715  Z-score: 4359.6  bits: 817.9 E(85289):    0
Smith-Waterman score: 5715; 99.9% identity (100.0% similar) in 891 aa overlap (23-913:10-900)

               10        20        30        40        50        60
pF1KE4 MMSQSSGSGDGNDDEATTSKDGGFSSPSPSAAAAAQEVRSATDGNTSTTPPTSAKKRKLN
                             ::::::::::::::::::::::::::::::::::::::
NP_001              MKSVCPVTSGFSSPSPSAAAAAQEVRSATDGNTSTTPPTSAKKRKLN
                            10        20        30        40       

               70        80        90       100       110       120
pF1KE4 SSSSSSSNSSNEREDFDSTSSSSSTPPLQPRDSASPSTSSFCLGVSVAASSHVPIQKKLR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SSSSSSSNSSNEREDFDSTSSSSSTPPLQPRDSASPSTSSFCLGVSVAASSHVPIQKKLR
        50        60        70        80        90       100       

              130       140       150       160       170       180
pF1KE4 FEDTLEFVGFDAKMAEESSSSSSSSSPTAATSQQQQLKNKSILISSVASVHHANGLAKSS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FEDTLEFVGFDAKMAEESSSSSSSSSPTAATSQQQQLKNKSILISSVASVHHANGLAKSS
       110       120       130       140       150       160       

              190       200       210       220       230       240
pF1KE4 TTVSSFANSKPGSAKKLVIKNFKDKPKLPENYTDETWQKLKEAVEAIQNSTSIKYNLEEL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TTVSSFANSKPGSAKKLVIKNFKDKPKLPENYTDETWQKLKEAVEAIQNSTSIKYNLEEL
       170       180       190       200       210       220       

              250       260       270       280       290       300
pF1KE4 YQAVENLCSYKISANLYKQLRQICEDHIKAQIHQFREDSLDSVLFLKKIDRCWQNHCRQM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YQAVENLCSYKISANLYKQLRQICEDHIKAQIHQFREDSLDSVLFLKKIDRCWQNHCRQM
       230       240       250       260       270       280       

              310       320       330       340       350       360
pF1KE4 IMIRSIFLFLDRTYVLQNSMLPSIWDMGLELFRAHIISDQKVQNKTIDGILLLIERERNG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IMIRSIFLFLDRTYVLQNSMLPSIWDMGLELFRAHIISDQKVQNKTIDGILLLIERERNG
       290       300       310       320       330       340       

              370       380       390       400       410       420
pF1KE4 EAIDRSLLRSLLSMLSDLQIYQDSFEQRFLEETNRLYAAEGQKLMQEREVPEYLHHVNKR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EAIDRSLLRSLLSMLSDLQIYQDSFEQRFLEETNRLYAAEGQKLMQEREVPEYLHHVNKR
       350       360       370       380       390       400       

              430       440       450       460       470       480
pF1KE4 LEEEADRLITYLDQTTQKSLIATVEKQLLGEHLTAILQKGLNNLLDENRIQDLSLLYQLF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LEEEADRLITYLDQTTQKSLIATVEKQLLGEHLTAILQKGLNNLLDENRIQDLSLLYQLF
       410       420       430       440       450       460       

              490       500       510       520       530       540
pF1KE4 SRVRGGVQVLLQQWIEYIKAFGSTIVINPEKDKTMVQELLDFKDKVDHIIDICFLKNEKF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SRVRGGVQVLLQQWIEYIKAFGSTIVINPEKDKTMVQELLDFKDKVDHIIDICFLKNEKF
       470       480       490       500       510       520       

              550       560       570       580       590       600
pF1KE4 INAMKEAFETFINKRPNKPAELIAKYVDSKLRAGNKEATDEELEKMLDKIMIIFRFIYGK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 INAMKEAFETFINKRPNKPAELIAKYVDSKLRAGNKEATDEELEKMLDKIMIIFRFIYGK
       530       540       550       560       570       580       

              610       620       630       640       650       660
pF1KE4 DVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMI
       590       600       610       620       630       640       

              670       680       690       700       710       720
pF1KE4 QFKQYMQNQNVPGNIELTVNILTMGYWPTYVPMEVHLPPEMVKLQEIFKTFYLGKHSGRK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QFKQYMQNQNVPGNIELTVNILTMGYWPTYVPMEVHLPPEMVKLQEIFKTFYLGKHSGRK
       650       660       670       680       690       700       

              730       740       750       760       770       780
pF1KE4 LQWQSTIGHCVLKAEFKEGKKELQVSLFQTLVLLMFNEGEEFSLEEIKQATGIEDGELRR
       ::::::.:::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LQWQSTLGHCVLKAEFKEGKKELQVSLFQTLVLLMFNEGEEFSLEEIKQATGIEDGELRR
       710       720       730       740       750       760       

              790       800       810       820       830       840
pF1KE4 TLQSLACGKARVLAKNPKGKDIEDGDKFICNDDFKHKLFRIKINQIQMKETVEEQASTTE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TLQSLACGKARVLAKNPKGKDIEDGDKFICNDDFKHKLFRIKINQIQMKETVEEQASTTE
       770       780       790       800       810       820       

              850       860       870       880       890       900
pF1KE4 RVFQDRQYQIDAAIVRIMKMRKTLSHNLLVSEVYNQLKFPVKPADLKKRIESLIDRDYME
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RVFQDRQYQIDAAIVRIMKMRKTLSHNLLVSEVYNQLKFPVKPADLKKRIESLIDRDYME
       830       840       850       860       870       880       

              910   
pF1KE4 RDKENPNQYNYIA
       :::::::::::::
NP_001 RDKENPNQYNYIA
       890       900

>>XP_006724847 (OMIM: 300304,300354) PREDICTED: cullin-4  (902 aa)
 initn: 4085 init1: 4085 opt: 5701  Z-score: 4348.9  bits: 815.9 E(85289):    0
Smith-Waterman score: 5701; 99.7% identity (99.8% similar) in 893 aa overlap (23-913:10-902)

               10        20        30        40        50        60
pF1KE4 MMSQSSGSGDGNDDEATTSKDGGFSSPSPSAAAAAQEVRSATDGNTSTTPPTSAKKRKLN
                             ::::::::::::::::::::::::::::::::::::::
XP_006              MKSVCPVTSGFSSPSPSAAAAAQEVRSATDGNTSTTPPTSAKKRKLN
                            10        20        30        40       

               70        80        90       100       110       120
pF1KE4 SSSSSSSNSSNEREDFDSTSSSSSTPPLQPRDSASPSTSSFCLGVSVAASSHVPIQKKLR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SSSSSSSNSSNEREDFDSTSSSSSTPPLQPRDSASPSTSSFCLGVSVAASSHVPIQKKLR
        50        60        70        80        90       100       

              130       140       150       160       170       180
pF1KE4 FEDTLEFVGFDAKMAEESSSSSSSSSPTAATSQQQQLKNKSILISSVASVHHANGLAKSS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 FEDTLEFVGFDAKMAEESSSSSSSSSPTAATSQQQQLKNKSILISSVASVHHANGLAKSS
       110       120       130       140       150       160       

              190       200       210       220       230       240
pF1KE4 TTVSSFANSKPGSAKKLVIKNFKDKPKLPENYTDETWQKLKEAVEAIQNSTSIKYNLEEL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 TTVSSFANSKPGSAKKLVIKNFKDKPKLPENYTDETWQKLKEAVEAIQNSTSIKYNLEEL
       170       180       190       200       210       220       

              250       260       270       280       290       300
pF1KE4 YQAVENLCSYKISANLYKQLRQICEDHIKAQIHQFREDSLDSVLFLKKIDRCWQNHCRQM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 YQAVENLCSYKISANLYKQLRQICEDHIKAQIHQFREDSLDSVLFLKKIDRCWQNHCRQM
       230       240       250       260       270       280       

              310       320       330       340       350       360
pF1KE4 IMIRSIFLFLDRTYVLQNSMLPSIWDMGLELFRAHIISDQKVQNKTIDGILLLIERERNG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 IMIRSIFLFLDRTYVLQNSMLPSIWDMGLELFRAHIISDQKVQNKTIDGILLLIERERNG
       290       300       310       320       330       340       

              370       380       390       400       410       420
pF1KE4 EAIDRSLLRSLLSMLSDLQIYQDSFEQRFLEETNRLYAAEGQKLMQEREVPEYLHHVNKR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EAIDRSLLRSLLSMLSDLQIYQDSFEQRFLEETNRLYAAEGQKLMQEREVPEYLHHVNKR
       350       360       370       380       390       400       

              430       440       450       460       470       480
pF1KE4 LEEEADRLITYLDQTTQKSLIATVEKQLLGEHLTAILQKGLNNLLDENRIQDLSLLYQLF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LEEEADRLITYLDQTTQKSLIATVEKQLLGEHLTAILQKGLNNLLDENRIQDLSLLYQLF
       410       420       430       440       450       460       

              490       500       510       520       530       540
pF1KE4 SRVRGGVQVLLQQWIEYIKAFGSTIVINPEKDKTMVQELLDFKDKVDHIIDICFLKNEKF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SRVRGGVQVLLQQWIEYIKAFGSTIVINPEKDKTMVQELLDFKDKVDHIIDICFLKNEKF
       470       480       490       500       510       520       

              550       560       570       580       590       600
pF1KE4 INAMKEAFETFINKRPNKPAELIAKYVDSKLRAGNKEATDEELEKMLDKIMIIFRFIYGK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 INAMKEAFETFINKRPNKPAELIAKYVDSKLRAGNKEATDEELEKMLDKIMIIFRFIYGK
       530       540       550       560       570       580       

              610       620       630       640       650       660
pF1KE4 DVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 DVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMI
       590       600       610       620       630       640       

                670       680       690       700       710        
pF1KE4 QFKQ--YMQNQNVPGNIELTVNILTMGYWPTYVPMEVHLPPEMVKLQEIFKTFYLGKHSG
       ::::  ::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 QFKQVKYMQNQNVPGNIELTVNILTMGYWPTYVPMEVHLPPEMVKLQEIFKTFYLGKHSG
       650       660       670       680       690       700       

      720       730       740       750       760       770        
pF1KE4 RKLQWQSTIGHCVLKAEFKEGKKELQVSLFQTLVLLMFNEGEEFSLEEIKQATGIEDGEL
       ::::::::.:::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 RKLQWQSTLGHCVLKAEFKEGKKELQVSLFQTLVLLMFNEGEEFSLEEIKQATGIEDGEL
       710       720       730       740       750       760       

      780       790       800       810       820       830        
pF1KE4 RRTLQSLACGKARVLAKNPKGKDIEDGDKFICNDDFKHKLFRIKINQIQMKETVEEQAST
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 RRTLQSLACGKARVLAKNPKGKDIEDGDKFICNDDFKHKLFRIKINQIQMKETVEEQAST
       770       780       790       800       810       820       

      840       850       860       870       880       890        
pF1KE4 TERVFQDRQYQIDAAIVRIMKMRKTLSHNLLVSEVYNQLKFPVKPADLKKRIESLIDRDY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 TERVFQDRQYQIDAAIVRIMKMRKTLSHNLLVSEVYNQLKFPVKPADLKKRIESLIDRDY
       830       840       850       860       870       880       

      900       910   
pF1KE4 MERDKENPNQYNYIA
       :::::::::::::::
XP_006 MERDKENPNQYNYIA
       890       900  

>>XP_011529702 (OMIM: 300304,300354) PREDICTED: cullin-4  (717 aa)
 initn: 4618 init1: 4618 opt: 4620  Z-score: 3527.6  bits: 663.6 E(85289): 9.5e-190
Smith-Waterman score: 4620; 99.0% identity (99.6% similar) in 717 aa overlap (197-913:1-717)

        170       180       190       200       210       220      
pF1KE4 VASVHHANGLAKSSTTVSSFANSKPGSAKKLVIKNFKDKPKLPENYTDETWQKLKEAVEA
                                     ..  .: :::::::::::::::::::::::
XP_011                               MIDPDFADKPKLPENYTDETWQKLKEAVEA
                                             10        20        30

        230       240       250       260       270       280      
pF1KE4 IQNSTSIKYNLEELYQAVENLCSYKISANLYKQLRQICEDHIKAQIHQFREDSLDSVLFL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IQNSTSIKYNLEELYQAVENLCSYKISANLYKQLRQICEDHIKAQIHQFREDSLDSVLFL
               40        50        60        70        80        90

        290       300       310       320       330       340      
pF1KE4 KKIDRCWQNHCRQMIMIRSIFLFLDRTYVLQNSMLPSIWDMGLELFRAHIISDQKVQNKT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KKIDRCWQNHCRQMIMIRSIFLFLDRTYVLQNSMLPSIWDMGLELFRAHIISDQKVQNKT
              100       110       120       130       140       150

        350       360       370       380       390       400      
pF1KE4 IDGILLLIERERNGEAIDRSLLRSLLSMLSDLQIYQDSFEQRFLEETNRLYAAEGQKLMQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IDGILLLIERERNGEAIDRSLLRSLLSMLSDLQIYQDSFEQRFLEETNRLYAAEGQKLMQ
              160       170       180       190       200       210

        410       420       430       440       450       460      
pF1KE4 EREVPEYLHHVNKRLEEEADRLITYLDQTTQKSLIATVEKQLLGEHLTAILQKGLNNLLD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EREVPEYLHHVNKRLEEEADRLITYLDQTTQKSLIATVEKQLLGEHLTAILQKGLNNLLD
              220       230       240       250       260       270

        470       480       490       500       510       520      
pF1KE4 ENRIQDLSLLYQLFSRVRGGVQVLLQQWIEYIKAFGSTIVINPEKDKTMVQELLDFKDKV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ENRIQDLSLLYQLFSRVRGGVQVLLQQWIEYIKAFGSTIVINPEKDKTMVQELLDFKDKV
              280       290       300       310       320       330

        530       540       550       560       570       580      
pF1KE4 DHIIDICFLKNEKFINAMKEAFETFINKRPNKPAELIAKYVDSKLRAGNKEATDEELEKM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DHIIDICFLKNEKFINAMKEAFETFINKRPNKPAELIAKYVDSKLRAGNKEATDEELEKM
              340       350       360       370       380       390

        590       600       610       620       630       640      
pF1KE4 LDKIMIIFRFIYGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LDKIMIIFRFIYGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLE
              400       410       420       430       440       450

        650       660       670       680       690       700      
pF1KE4 GMFKDMELSKDIMIQFKQYMQNQNVPGNIELTVNILTMGYWPTYVPMEVHLPPEMVKLQE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GMFKDMELSKDIMIQFKQYMQNQNVPGNIELTVNILTMGYWPTYVPMEVHLPPEMVKLQE
              460       470       480       490       500       510

        710       720       730       740       750       760      
pF1KE4 IFKTFYLGKHSGRKLQWQSTIGHCVLKAEFKEGKKELQVSLFQTLVLLMFNEGEEFSLEE
       ::::::::::::::::::::.:::::::::::::::::::::::::::::::::::::::
XP_011 IFKTFYLGKHSGRKLQWQSTLGHCVLKAEFKEGKKELQVSLFQTLVLLMFNEGEEFSLEE
              520       530       540       550       560       570

        770       780       790       800       810       820      
pF1KE4 IKQATGIEDGELRRTLQSLACGKARVLAKNPKGKDIEDGDKFICNDDFKHKLFRIKINQI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IKQATGIEDGELRRTLQSLACGKARVLAKNPKGKDIEDGDKFICNDDFKHKLFRIKINQI
              580       590       600       610       620       630

        830       840       850       860       870       880      
pF1KE4 QMKETVEEQASTTERVFQDRQYQIDAAIVRIMKMRKTLSHNLLVSEVYNQLKFPVKPADL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QMKETVEEQASTTERVFQDRQYQIDAAIVRIMKMRKTLSHNLLVSEVYNQLKFPVKPADL
              640       650       660       670       680       690

        890       900       910   
pF1KE4 KKRIESLIDRDYMERDKENPNQYNYIA
       :::::::::::::::::::::::::::
XP_011 KKRIESLIDRDYMERDKENPNQYNYIA
              700       710       

>>XP_011529701 (OMIM: 300304,300354) PREDICTED: cullin-4  (719 aa)
 initn: 2988 init1: 2988 opt: 4606  Z-score: 3516.9  bits: 661.7 E(85289): 3.7e-189
Smith-Waterman score: 4606; 98.7% identity (99.3% similar) in 719 aa overlap (197-913:1-719)

        170       180       190       200       210       220      
pF1KE4 VASVHHANGLAKSSTTVSSFANSKPGSAKKLVIKNFKDKPKLPENYTDETWQKLKEAVEA
                                     ..  .: :::::::::::::::::::::::
XP_011                               MIDPDFADKPKLPENYTDETWQKLKEAVEA
                                             10        20        30

        230       240       250       260       270       280      
pF1KE4 IQNSTSIKYNLEELYQAVENLCSYKISANLYKQLRQICEDHIKAQIHQFREDSLDSVLFL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IQNSTSIKYNLEELYQAVENLCSYKISANLYKQLRQICEDHIKAQIHQFREDSLDSVLFL
               40        50        60        70        80        90

        290       300       310       320       330       340      
pF1KE4 KKIDRCWQNHCRQMIMIRSIFLFLDRTYVLQNSMLPSIWDMGLELFRAHIISDQKVQNKT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KKIDRCWQNHCRQMIMIRSIFLFLDRTYVLQNSMLPSIWDMGLELFRAHIISDQKVQNKT
              100       110       120       130       140       150

        350       360       370       380       390       400      
pF1KE4 IDGILLLIERERNGEAIDRSLLRSLLSMLSDLQIYQDSFEQRFLEETNRLYAAEGQKLMQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IDGILLLIERERNGEAIDRSLLRSLLSMLSDLQIYQDSFEQRFLEETNRLYAAEGQKLMQ
              160       170       180       190       200       210

        410       420       430       440       450       460      
pF1KE4 EREVPEYLHHVNKRLEEEADRLITYLDQTTQKSLIATVEKQLLGEHLTAILQKGLNNLLD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EREVPEYLHHVNKRLEEEADRLITYLDQTTQKSLIATVEKQLLGEHLTAILQKGLNNLLD
              220       230       240       250       260       270

        470       480       490       500       510       520      
pF1KE4 ENRIQDLSLLYQLFSRVRGGVQVLLQQWIEYIKAFGSTIVINPEKDKTMVQELLDFKDKV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ENRIQDLSLLYQLFSRVRGGVQVLLQQWIEYIKAFGSTIVINPEKDKTMVQELLDFKDKV
              280       290       300       310       320       330

        530       540       550       560       570       580      
pF1KE4 DHIIDICFLKNEKFINAMKEAFETFINKRPNKPAELIAKYVDSKLRAGNKEATDEELEKM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DHIIDICFLKNEKFINAMKEAFETFINKRPNKPAELIAKYVDSKLRAGNKEATDEELEKM
              340       350       360       370       380       390

        590       600       610       620       630       640      
pF1KE4 LDKIMIIFRFIYGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LDKIMIIFRFIYGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLE
              400       410       420       430       440       450

        650       660         670       680       690       700    
pF1KE4 GMFKDMELSKDIMIQFKQ--YMQNQNVPGNIELTVNILTMGYWPTYVPMEVHLPPEMVKL
       ::::::::::::::::::  ::::::::::::::::::::::::::::::::::::::::
XP_011 GMFKDMELSKDIMIQFKQVKYMQNQNVPGNIELTVNILTMGYWPTYVPMEVHLPPEMVKL
              460       470       480       490       500       510

          710       720       730       740       750       760    
pF1KE4 QEIFKTFYLGKHSGRKLQWQSTIGHCVLKAEFKEGKKELQVSLFQTLVLLMFNEGEEFSL
       ::::::::::::::::::::::.:::::::::::::::::::::::::::::::::::::
XP_011 QEIFKTFYLGKHSGRKLQWQSTLGHCVLKAEFKEGKKELQVSLFQTLVLLMFNEGEEFSL
              520       530       540       550       560       570

          770       780       790       800       810       820    
pF1KE4 EEIKQATGIEDGELRRTLQSLACGKARVLAKNPKGKDIEDGDKFICNDDFKHKLFRIKIN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EEIKQATGIEDGELRRTLQSLACGKARVLAKNPKGKDIEDGDKFICNDDFKHKLFRIKIN
              580       590       600       610       620       630

          830       840       850       860       870       880    
pF1KE4 QIQMKETVEEQASTTERVFQDRQYQIDAAIVRIMKMRKTLSHNLLVSEVYNQLKFPVKPA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QIQMKETVEEQASTTERVFQDRQYQIDAAIVRIMKMRKTLSHNLLVSEVYNQLKFPVKPA
              640       650       660       670       680       690

          890       900       910   
pF1KE4 DLKKRIESLIDRDYMERDKENPNQYNYIA
       :::::::::::::::::::::::::::::
XP_011 DLKKRIESLIDRDYMERDKENPNQYNYIA
              700       710         

>>XP_011529703 (OMIM: 300304,300354) PREDICTED: cullin-4  (701 aa)
 initn: 2728 init1: 2728 opt: 4346  Z-score: 3319.2  bits: 625.0 E(85289): 3.9e-178
Smith-Waterman score: 4346; 96.4% identity (98.0% similar) in 699 aa overlap (217-913:9-701)

        190       200       210       220       230       240      
pF1KE4 ANSKPGSAKKLVIKNFKDKPKLPENYTDETWQKLKEAVEAIQNSTSIKYNLEELYQAVEN
                                     :  :.. .  .. :.: .    .. .::::
XP_011                       MQILFMFLWIVLRKII--LRCSSSNR----RIKEAVEN
                                     10          20            30  

        250       260       270       280       290       300      
pF1KE4 LCSYKISANLYKQLRQICEDHIKAQIHQFREDSLDSVLFLKKIDRCWQNHCRQMIMIRSI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LCSYKISANLYKQLRQICEDHIKAQIHQFREDSLDSVLFLKKIDRCWQNHCRQMIMIRSI
             40        50        60        70        80        90  

        310       320       330       340       350       360      
pF1KE4 FLFLDRTYVLQNSMLPSIWDMGLELFRAHIISDQKVQNKTIDGILLLIERERNGEAIDRS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FLFLDRTYVLQNSMLPSIWDMGLELFRAHIISDQKVQNKTIDGILLLIERERNGEAIDRS
            100       110       120       130       140       150  

        370       380       390       400       410       420      
pF1KE4 LLRSLLSMLSDLQIYQDSFEQRFLEETNRLYAAEGQKLMQEREVPEYLHHVNKRLEEEAD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LLRSLLSMLSDLQIYQDSFEQRFLEETNRLYAAEGQKLMQEREVPEYLHHVNKRLEEEAD
            160       170       180       190       200       210  

        430       440       450       460       470       480      
pF1KE4 RLITYLDQTTQKSLIATVEKQLLGEHLTAILQKGLNNLLDENRIQDLSLLYQLFSRVRGG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RLITYLDQTTQKSLIATVEKQLLGEHLTAILQKGLNNLLDENRIQDLSLLYQLFSRVRGG
            220       230       240       250       260       270  

        490       500       510       520       530       540      
pF1KE4 VQVLLQQWIEYIKAFGSTIVINPEKDKTMVQELLDFKDKVDHIIDICFLKNEKFINAMKE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VQVLLQQWIEYIKAFGSTIVINPEKDKTMVQELLDFKDKVDHIIDICFLKNEKFINAMKE
            280       290       300       310       320       330  

        550       560       570       580       590       600      
pF1KE4 AFETFINKRPNKPAELIAKYVDSKLRAGNKEATDEELEKMLDKIMIIFRFIYGKDVFEAF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AFETFINKRPNKPAELIAKYVDSKLRAGNKEATDEELEKMLDKIMIIFRFIYGKDVFEAF
            340       350       360       370       380       390  

        610       620       630       640       650       660      
pF1KE4 YKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMIQFKQ--
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::  
XP_011 YKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMIQFKQVK
            400       410       420       430       440       450  

          670       680       690       700       710       720    
pF1KE4 YMQNQNVPGNIELTVNILTMGYWPTYVPMEVHLPPEMVKLQEIFKTFYLGKHSGRKLQWQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YMQNQNVPGNIELTVNILTMGYWPTYVPMEVHLPPEMVKLQEIFKTFYLGKHSGRKLQWQ
            460       470       480       490       500       510  

          730       740       750       760       770       780    
pF1KE4 STIGHCVLKAEFKEGKKELQVSLFQTLVLLMFNEGEEFSLEEIKQATGIEDGELRRTLQS
       ::.:::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 STLGHCVLKAEFKEGKKELQVSLFQTLVLLMFNEGEEFSLEEIKQATGIEDGELRRTLQS
            520       530       540       550       560       570  

          790       800       810       820       830       840    
pF1KE4 LACGKARVLAKNPKGKDIEDGDKFICNDDFKHKLFRIKINQIQMKETVEEQASTTERVFQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LACGKARVLAKNPKGKDIEDGDKFICNDDFKHKLFRIKINQIQMKETVEEQASTTERVFQ
            580       590       600       610       620       630  

          850       860       870       880       890       900    
pF1KE4 DRQYQIDAAIVRIMKMRKTLSHNLLVSEVYNQLKFPVKPADLKKRIESLIDRDYMERDKE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DRQYQIDAAIVRIMKMRKTLSHNLLVSEVYNQLKFPVKPADLKKRIESLIDRDYMERDKE
            640       650       660       670       680       690  

          910   
pF1KE4 NPNQYNYIA
       :::::::::
XP_011 NPNQYNYIA
            700 

>>NP_001008895 (OMIM: 603137) cullin-4A isoform 1 [Homo   (759 aa)
 initn: 4069 init1: 4069 opt: 4103  Z-score: 3133.6  bits: 590.8 E(85289): 8.4e-168
Smith-Waterman score: 4103; 82.6% identity (94.8% similar) in 749 aa overlap (168-913:13-759)

       140       150       160       170       180       190       
pF1KE4 SSSSSSSSSPTAATSQQQQLKNKSILISSVASVHHANGLAKSSTTVSSFANSKPGSA---
                                     : : ..:::.: .. ..  : .:::.:   
NP_001                   MADEAPRKGSFSALVGRTNGLTKPAALAA--APAKPGGAGGS
                                 10        20          30        40

          200       210       220       230       240       250    
pF1KE4 KKLVIKNFKDKPKLPENYTDETWQKLKEAVEAIQNSTSIKYNLEELYQAVENLCSYKISA
       ::::::::.:.:.::.:::..::.::.:::.:.:.::::.:::::::::::::::.:.: 
NP_001 KKLVIKNFRDRPRLPDNYTQDTWRKLHEAVRAVQSSTSIRYNLEELYQAVENLCSHKVSP
               50        60        70        80        90       100

          260       270       280       290       300       310    
pF1KE4 NLYKQLRQICEDHIKAQIHQFREDSLDSVLFLKKIDRCWQNHCRQMIMIRSIFLFLDRTY
        ::::::: ::::..:::  :::::::::::::::. :::.:::::::::::::::::::
NP_001 MLYKQLRQACEDHVQAQILPFREDSLDSVLFLKKINTCWQDHCRQMIMIRSIFLFLDRTY
              110       120       130       140       150       160

          320       330       340       350       360       370    
pF1KE4 VLQNSMLPSIWDMGLELFRAHIISDQKVQNKTIDGILLLIERERNGEAIDRSLLRSLLSM
       ::::: :::::::::::::.:::::. ::.::::::::::::::.:::.:::::::::.:
NP_001 VLQNSTLPSIWDMGLELFRTHIISDKMVQSKTIDGILLLIERERSGEAVDRSLLRSLLGM
              170       180       190       200       210       220

          380       390       400       410       420       430    
pF1KE4 LSDLQIYQDSFEQRFLEETNRLYAAEGQKLMQEREVPEYLHHVNKRLEEEADRLITYLDQ
       :::::.:.:::: .:::::: :::::::.:::::::::::.::.::::::.::.:::::.
NP_001 LSDLQVYKDSFELKFLEETNCLYAAEGQRLMQEREVPEYLNHVSKRLEEEGDRVITYLDH
              230       240       250       260       270       280

          440       450       460       470       480       490    
pF1KE4 TTQKSLIATVEKQLLGEHLTAILQKGLNNLLDENRIQDLSLLYQLFSRVRGGVQVLLQQW
       .::: ::: ::::::::::::::::::..::::::. ::. .:::::::::: :.:::.:
NP_001 STQKPLIACVEKQLLGEHLTAILQKGLDHLLDENRVPDLAQMYQLFSRVRGGQQALLQHW
              290       300       310       320       330       340

          500       510       520       530       540       550    
pF1KE4 IEYIKAFGSTIVINPEKDKTMVQELLDFKDKVDHIIDICFLKNEKFINAMKEAFETFINK
        ::::.::..::::::::: :::.::::::::::.:..:: :::.:.: :::.:::::::
NP_001 SEYIKTFGTAIVINPEKDKDMVQDLLDFKDKVDHVIEVCFQKNERFVNLMKESFETFINK
              350       360       370       380       390       400

          560       570       580       590       600       610    
pF1KE4 RPNKPAELIAKYVDSKLRAGNKEATDEELEKMLDKIMIIFRFIYGKDVFEAFYKKDLAKR
       :::::::::::.::::::::::::::::::. ::::::.::::.::::::::::::::::
NP_001 RPNKPAELIAKHVDSKLRAGNKEATDEELERTLDKIMILFRFIHGKDVFEAFYKKDLAKR
              410       420       430       440       450       460

          620       630       640       650       660       670    
pF1KE4 LLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMIQFKQYMQNQNVPGN
       :::::::::::::::::::::::::::::::::::::::::::::..:::.::::.  : 
NP_001 LLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMVHFKQHMQNQSDSGP
              470       480       490       500       510       520

          680       690       700       710       720       730    
pF1KE4 IELTVNILTMGYWPTYVPMEVHLPPEMVKLQEIFKTFYLGKHSGRKLQWQSTIGHCVLKA
       :.::::::::::::::.:::::: :::.::::.::.::::::::::::::.:.:: ::::
NP_001 IDLTVNILTMGYWPTYTPMEVHLTPEMIKLQEVFKAFYLGKHSGRKLQWQTTLGHAVLKA
              530       540       550       560       570       580

          740       750       760       770       780       790    
pF1KE4 EFKEGKKELQVSLFQTLVLLMFNEGEEFSLEEIKQATGIEDGELRRTLQSLACGKARVLA
       ::::::::.::::::::::::::::. ::.::::.::::::.::::::::::::::::: 
NP_001 EFKEGKKEFQVSLFQTLVLLMFNEGDGFSFEEIKMATGIEDSELRRTLQSLACGKARVLI
              590       600       610       620       630       640

          800       810       820       830       840       850    
pF1KE4 KNPKGKDIEDGDKFICNDDFKHKLFRIKINQIQMKETVEEQASTTERVFQDRQYQIDAAI
       :.::::..::::::: : .::::::::::::::::::::::.::::::::::::::::::
NP_001 KSPKGKEVEDGDKFIFNGEFKHKLFRIKINQIQMKETVEEQVSTTERVFQDRQYQIDAAI
              650       660       670       680       690       700

          860       870       880       890       900       910   
pF1KE4 VRIMKMRKTLSHNLLVSEVYNQLKFPVKPADLKKRIESLIDRDYMERDKENPNQYNYIA
       ::::::::::.:::::::.::::::::::.:::::::::::::::::::.:::::.:.:
NP_001 VRIMKMRKTLGHNLLVSELYNQLKFPVKPGDLKKRIESLIDRDYMERDKDNPNQYHYVA
              710       720       730       740       750         

>>NP_003580 (OMIM: 603137) cullin-4A isoform 2 [Homo sap  (659 aa)
 initn: 3755 init1: 3755 opt: 3755  Z-score: 2869.7  bits: 541.8 E(85289): 4.2e-153
Smith-Waterman score: 3755; 85.6% identity (95.9% similar) in 658 aa overlap (256-913:2-659)

         230       240       250       260       270       280     
pF1KE4 AIQNSTSIKYNLEELYQAVENLCSYKISANLYKQLRQICEDHIKAQIHQFREDSLDSVLF
                                     ::::::: ::::..:::  :::::::::::
NP_003                              MLYKQLRQACEDHVQAQILPFREDSLDSVLF
                                            10        20        30 

         290       300       310       320       330       340     
pF1KE4 LKKIDRCWQNHCRQMIMIRSIFLFLDRTYVLQNSMLPSIWDMGLELFRAHIISDQKVQNK
       ::::. :::.:::::::::::::::::::::::: :::::::::::::.:::::. ::.:
NP_003 LKKINTCWQDHCRQMIMIRSIFLFLDRTYVLQNSTLPSIWDMGLELFRTHIISDKMVQSK
              40        50        60        70        80        90 

         350       360       370       380       390       400     
pF1KE4 TIDGILLLIERERNGEAIDRSLLRSLLSMLSDLQIYQDSFEQRFLEETNRLYAAEGQKLM
       :::::::::::::.:::.:::::::::.::::::.:.:::: .:::::: :::::::.::
NP_003 TIDGILLLIERERSGEAVDRSLLRSLLGMLSDLQVYKDSFELKFLEETNCLYAAEGQRLM
             100       110       120       130       140       150 

         410       420       430       440       450       460     
pF1KE4 QEREVPEYLHHVNKRLEEEADRLITYLDQTTQKSLIATVEKQLLGEHLTAILQKGLNNLL
       :::::::::.::.::::::.::.:::::..::: ::: ::::::::::::::::::..::
NP_003 QEREVPEYLNHVSKRLEEEGDRVITYLDHSTQKPLIACVEKQLLGEHLTAILQKGLDHLL
             160       170       180       190       200       210 

         470       480       490       500       510       520     
pF1KE4 DENRIQDLSLLYQLFSRVRGGVQVLLQQWIEYIKAFGSTIVINPEKDKTMVQELLDFKDK
       ::::. ::. .:::::::::: :.:::.: ::::.::..::::::::: :::.:::::::
NP_003 DENRVPDLAQMYQLFSRVRGGQQALLQHWSEYIKTFGTAIVINPEKDKDMVQDLLDFKDK
             220       230       240       250       260       270 

         530       540       550       560       570       580     
pF1KE4 VDHIIDICFLKNEKFINAMKEAFETFINKRPNKPAELIAKYVDSKLRAGNKEATDEELEK
       :::.:..:: :::.:.: :::.::::::::::::::::::.::::::::::::::::::.
NP_003 VDHVIEVCFQKNERFVNLMKESFETFINKRPNKPAELIAKHVDSKLRAGNKEATDEELER
             280       290       300       310       320       330 

         590       600       610       620       630       640     
pF1KE4 MLDKIMIIFRFIYGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKL
        ::::::.::::.:::::::::::::::::::::::::::::::::::::::::::::::
NP_003 TLDKIMILFRFIHGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKL
             340       350       360       370       380       390 

         650       660       670       680       690       700     
pF1KE4 EGMFKDMELSKDIMIQFKQYMQNQNVPGNIELTVNILTMGYWPTYVPMEVHLPPEMVKLQ
       ::::::::::::::..:::.::::.  : :.::::::::::::::.:::::: :::.:::
NP_003 EGMFKDMELSKDIMVHFKQHMQNQSDSGPIDLTVNILTMGYWPTYTPMEVHLTPEMIKLQ
             400       410       420       430       440       450 

         710       720       730       740       750       760     
pF1KE4 EIFKTFYLGKHSGRKLQWQSTIGHCVLKAEFKEGKKELQVSLFQTLVLLMFNEGEEFSLE
       :.::.::::::::::::::.:.:: ::::::::::::.::::::::::::::::. ::.:
NP_003 EVFKAFYLGKHSGRKLQWQTTLGHAVLKAEFKEGKKEFQVSLFQTLVLLMFNEGDGFSFE
             460       470       480       490       500       510 

         770       780       790       800       810       820     
pF1KE4 EIKQATGIEDGELRRTLQSLACGKARVLAKNPKGKDIEDGDKFICNDDFKHKLFRIKINQ
       :::.::::::.::::::::::::::::: :.::::..::::::: : .::::::::::::
NP_003 EIKMATGIEDSELRRTLQSLACGKARVLIKSPKGKEVEDGDKFIFNGEFKHKLFRIKINQ
             520       530       540       550       560       570 

         830       840       850       860       870       880     
pF1KE4 IQMKETVEEQASTTERVFQDRQYQIDAAIVRIMKMRKTLSHNLLVSEVYNQLKFPVKPAD
       ::::::::::.::::::::::::::::::::::::::::.:::::::.::::::::::.:
NP_003 IQMKETVEEQVSTTERVFQDRQYQIDAAIVRIMKMRKTLGHNLLVSELYNQLKFPVKPGD
             580       590       600       610       620       630 

         890       900       910   
pF1KE4 LKKRIESLIDRDYMERDKENPNQYNYIA
       ::::::::::::::::::.:::::.:.:
NP_003 LKKRIESLIDRDYMERDKDNPNQYHYVA
             640       650         




913 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Mon Nov  7 16:57:56 2016 done: Mon Nov  7 16:57:58 2016
 Total Scan time: 13.040 Total Display time:  0.230

Function used was FASTA [36.3.4 Apr, 2011]
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