FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE4588, 913 aa 1>>>pF1KE4588 913 - 913 aa - 913 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 9.4682+/-0.000433; mu= 1.1909+/- 0.027 mean_var=172.5482+/-35.958, 0's: 0 Z-trim(116.5): 52 B-trim: 1718 in 2/55 Lambda= 0.097638 statistics sampled from 27586 (27638) to 27586 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.653), E-opt: 0.2 (0.324), width: 16 Scan time: 13.040 The best scores are: opt bits E(85289) NP_003579 (OMIM: 300304,300354) cullin-4B isoform ( 913) 5859 838.2 0 XP_005262538 (OMIM: 300304,300354) PREDICTED: cull ( 915) 5845 836.2 0 NP_001073341 (OMIM: 300304,300354) cullin-4B isofo ( 895) 5715 817.9 0 NP_001317553 (OMIM: 300304,300354) cullin-4B isofo ( 900) 5715 817.9 0 XP_006724847 (OMIM: 300304,300354) PREDICTED: cull ( 902) 5701 815.9 0 XP_011529702 (OMIM: 300304,300354) PREDICTED: cull ( 717) 4620 663.6 9.5e-190 XP_011529701 (OMIM: 300304,300354) PREDICTED: cull ( 719) 4606 661.7 3.7e-189 XP_011529703 (OMIM: 300304,300354) PREDICTED: cull ( 701) 4346 625.0 3.9e-178 NP_001008895 (OMIM: 603137) cullin-4A isoform 1 [H ( 759) 4103 590.8 8.4e-168 NP_003580 (OMIM: 603137) cullin-4A isoform 2 [Homo ( 659) 3755 541.8 4.2e-153 NP_001265442 (OMIM: 603137) cullin-4A isoform 2 [H ( 659) 3755 541.8 4.2e-153 XP_011535825 (OMIM: 603137) PREDICTED: cullin-4A i ( 659) 3755 541.8 4.2e-153 NP_001265443 (OMIM: 603137) cullin-4A isoform 3 [H ( 667) 3711 535.6 3.1e-151 NP_001311305 (OMIM: 603135) cullin-2 isoform e [Ho ( 614) 979 150.7 2e-35 NP_001311304 (OMIM: 603135) cullin-2 isoform d [Ho ( 682) 979 150.7 2.2e-35 XP_011518049 (OMIM: 603135) PREDICTED: cullin-2 is ( 745) 979 150.7 2.4e-35 NP_003582 (OMIM: 603135) cullin-2 isoform c [Homo ( 745) 979 150.7 2.4e-35 NP_001185706 (OMIM: 603135) cullin-2 isoform c [Ho ( 745) 979 150.7 2.4e-35 NP_001185708 (OMIM: 603135) cullin-2 isoform b [Ho ( 758) 979 150.8 2.5e-35 NP_001185707 (OMIM: 603135) cullin-2 isoform a [Ho ( 764) 979 150.8 2.5e-35 XP_011518046 (OMIM: 603135) PREDICTED: cullin-2 is ( 808) 979 150.8 2.6e-35 XP_011518045 (OMIM: 603135) PREDICTED: cullin-2 is ( 808) 979 150.8 2.6e-35 XP_011518047 (OMIM: 603135) PREDICTED: cullin-2 is ( 808) 979 150.8 2.6e-35 NP_003581 (OMIM: 603136,614496) cullin-3 isoform 1 ( 768) 977 150.5 3e-35 XP_011510297 (OMIM: 603136,614496) PREDICTED: cull ( 754) 972 149.8 4.8e-35 XP_006712863 (OMIM: 603136,614496) PREDICTED: cull ( 757) 972 149.8 4.9e-35 NP_001244127 (OMIM: 603136,614496) cullin-3 isofor ( 774) 972 149.8 5e-35 NP_001244126 (OMIM: 603136,614496) cullin-3 isofor ( 702) 888 137.9 1.7e-31 XP_011510298 (OMIM: 603136,614496) PREDICTED: cull ( 704) 888 137.9 1.7e-31 XP_011510296 (OMIM: 603136,614496) PREDICTED: cull ( 719) 888 137.9 1.7e-31 XP_011514933 (OMIM: 603134) PREDICTED: cullin-1 is ( 776) 872 135.7 8.6e-31 XP_005250117 (OMIM: 603134) PREDICTED: cullin-1 is ( 776) 872 135.7 8.6e-31 XP_011514934 (OMIM: 603134) PREDICTED: cullin-1 is ( 776) 872 135.7 8.6e-31 XP_011514931 (OMIM: 603134) PREDICTED: cullin-1 is ( 776) 872 135.7 8.6e-31 XP_011514932 (OMIM: 603134) PREDICTED: cullin-1 is ( 776) 872 135.7 8.6e-31 NP_003583 (OMIM: 603134) cullin-1 [Homo sapiens] ( 776) 872 135.7 8.6e-31 XP_016868212 (OMIM: 603134) PREDICTED: cullin-1 is ( 455) 839 131.0 1.3e-29 XP_016873854 (OMIM: 601741) PREDICTED: cullin-5 is ( 519) 440 74.8 1.2e-12 XP_016873853 (OMIM: 601741) PREDICTED: cullin-5 is ( 519) 440 74.8 1.2e-12 XP_005271739 (OMIM: 601741) PREDICTED: cullin-5 is ( 721) 288 53.4 4.7e-06 XP_016873852 (OMIM: 601741) PREDICTED: cullin-5 is ( 742) 288 53.4 4.8e-06 NP_003469 (OMIM: 601741) cullin-5 [Homo sapiens] ( 780) 288 53.4 5e-06 XP_011541315 (OMIM: 601741) PREDICTED: cullin-5 is ( 396) 260 49.4 4.1e-05 NP_037498 (OMIM: 606946) anaphase-promoting comple ( 822) 226 44.7 0.0023 >>NP_003579 (OMIM: 300304,300354) cullin-4B isoform 1 [H (913 aa) initn: 5859 init1: 5859 opt: 5859 Z-score: 4469.1 bits: 838.2 E(85289): 0 Smith-Waterman score: 5859; 99.9% identity (100.0% similar) in 913 aa overlap (1-913:1-913) 10 20 30 40 50 60 pF1KE4 MMSQSSGSGDGNDDEATTSKDGGFSSPSPSAAAAAQEVRSATDGNTSTTPPTSAKKRKLN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 MMSQSSGSGDGNDDEATTSKDGGFSSPSPSAAAAAQEVRSATDGNTSTTPPTSAKKRKLN 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 SSSSSSSNSSNEREDFDSTSSSSSTPPLQPRDSASPSTSSFCLGVSVAASSHVPIQKKLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 SSSSSSSNSSNEREDFDSTSSSSSTPPLQPRDSASPSTSSFCLGVSVAASSHVPIQKKLR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 FEDTLEFVGFDAKMAEESSSSSSSSSPTAATSQQQQLKNKSILISSVASVHHANGLAKSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 FEDTLEFVGFDAKMAEESSSSSSSSSPTAATSQQQQLKNKSILISSVASVHHANGLAKSS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 TTVSSFANSKPGSAKKLVIKNFKDKPKLPENYTDETWQKLKEAVEAIQNSTSIKYNLEEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 TTVSSFANSKPGSAKKLVIKNFKDKPKLPENYTDETWQKLKEAVEAIQNSTSIKYNLEEL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 YQAVENLCSYKISANLYKQLRQICEDHIKAQIHQFREDSLDSVLFLKKIDRCWQNHCRQM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 YQAVENLCSYKISANLYKQLRQICEDHIKAQIHQFREDSLDSVLFLKKIDRCWQNHCRQM 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 IMIRSIFLFLDRTYVLQNSMLPSIWDMGLELFRAHIISDQKVQNKTIDGILLLIERERNG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 IMIRSIFLFLDRTYVLQNSMLPSIWDMGLELFRAHIISDQKVQNKTIDGILLLIERERNG 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE4 EAIDRSLLRSLLSMLSDLQIYQDSFEQRFLEETNRLYAAEGQKLMQEREVPEYLHHVNKR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 EAIDRSLLRSLLSMLSDLQIYQDSFEQRFLEETNRLYAAEGQKLMQEREVPEYLHHVNKR 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE4 LEEEADRLITYLDQTTQKSLIATVEKQLLGEHLTAILQKGLNNLLDENRIQDLSLLYQLF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 LEEEADRLITYLDQTTQKSLIATVEKQLLGEHLTAILQKGLNNLLDENRIQDLSLLYQLF 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE4 SRVRGGVQVLLQQWIEYIKAFGSTIVINPEKDKTMVQELLDFKDKVDHIIDICFLKNEKF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 SRVRGGVQVLLQQWIEYIKAFGSTIVINPEKDKTMVQELLDFKDKVDHIIDICFLKNEKF 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE4 INAMKEAFETFINKRPNKPAELIAKYVDSKLRAGNKEATDEELEKMLDKIMIIFRFIYGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 INAMKEAFETFINKRPNKPAELIAKYVDSKLRAGNKEATDEELEKMLDKIMIIFRFIYGK 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE4 DVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 DVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMI 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE4 QFKQYMQNQNVPGNIELTVNILTMGYWPTYVPMEVHLPPEMVKLQEIFKTFYLGKHSGRK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 QFKQYMQNQNVPGNIELTVNILTMGYWPTYVPMEVHLPPEMVKLQEIFKTFYLGKHSGRK 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE4 LQWQSTIGHCVLKAEFKEGKKELQVSLFQTLVLLMFNEGEEFSLEEIKQATGIEDGELRR ::::::.::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 LQWQSTLGHCVLKAEFKEGKKELQVSLFQTLVLLMFNEGEEFSLEEIKQATGIEDGELRR 730 740 750 760 770 780 790 800 810 820 830 840 pF1KE4 TLQSLACGKARVLAKNPKGKDIEDGDKFICNDDFKHKLFRIKINQIQMKETVEEQASTTE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 TLQSLACGKARVLAKNPKGKDIEDGDKFICNDDFKHKLFRIKINQIQMKETVEEQASTTE 790 800 810 820 830 840 850 860 870 880 890 900 pF1KE4 RVFQDRQYQIDAAIVRIMKMRKTLSHNLLVSEVYNQLKFPVKPADLKKRIESLIDRDYME :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 RVFQDRQYQIDAAIVRIMKMRKTLSHNLLVSEVYNQLKFPVKPADLKKRIESLIDRDYME 850 860 870 880 890 900 910 pF1KE4 RDKENPNQYNYIA ::::::::::::: NP_003 RDKENPNQYNYIA 910 >>XP_005262538 (OMIM: 300304,300354) PREDICTED: cullin-4 (915 aa) initn: 4229 init1: 4229 opt: 5845 Z-score: 4458.4 bits: 836.2 E(85289): 0 Smith-Waterman score: 5845; 99.7% identity (99.8% similar) in 915 aa overlap (1-913:1-915) 10 20 30 40 50 60 pF1KE4 MMSQSSGSGDGNDDEATTSKDGGFSSPSPSAAAAAQEVRSATDGNTSTTPPTSAKKRKLN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MMSQSSGSGDGNDDEATTSKDGGFSSPSPSAAAAAQEVRSATDGNTSTTPPTSAKKRKLN 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 SSSSSSSNSSNEREDFDSTSSSSSTPPLQPRDSASPSTSSFCLGVSVAASSHVPIQKKLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SSSSSSSNSSNEREDFDSTSSSSSTPPLQPRDSASPSTSSFCLGVSVAASSHVPIQKKLR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 FEDTLEFVGFDAKMAEESSSSSSSSSPTAATSQQQQLKNKSILISSVASVHHANGLAKSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 FEDTLEFVGFDAKMAEESSSSSSSSSPTAATSQQQQLKNKSILISSVASVHHANGLAKSS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 TTVSSFANSKPGSAKKLVIKNFKDKPKLPENYTDETWQKLKEAVEAIQNSTSIKYNLEEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TTVSSFANSKPGSAKKLVIKNFKDKPKLPENYTDETWQKLKEAVEAIQNSTSIKYNLEEL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 YQAVENLCSYKISANLYKQLRQICEDHIKAQIHQFREDSLDSVLFLKKIDRCWQNHCRQM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 YQAVENLCSYKISANLYKQLRQICEDHIKAQIHQFREDSLDSVLFLKKIDRCWQNHCRQM 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 IMIRSIFLFLDRTYVLQNSMLPSIWDMGLELFRAHIISDQKVQNKTIDGILLLIERERNG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 IMIRSIFLFLDRTYVLQNSMLPSIWDMGLELFRAHIISDQKVQNKTIDGILLLIERERNG 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE4 EAIDRSLLRSLLSMLSDLQIYQDSFEQRFLEETNRLYAAEGQKLMQEREVPEYLHHVNKR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EAIDRSLLRSLLSMLSDLQIYQDSFEQRFLEETNRLYAAEGQKLMQEREVPEYLHHVNKR 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE4 LEEEADRLITYLDQTTQKSLIATVEKQLLGEHLTAILQKGLNNLLDENRIQDLSLLYQLF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LEEEADRLITYLDQTTQKSLIATVEKQLLGEHLTAILQKGLNNLLDENRIQDLSLLYQLF 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE4 SRVRGGVQVLLQQWIEYIKAFGSTIVINPEKDKTMVQELLDFKDKVDHIIDICFLKNEKF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SRVRGGVQVLLQQWIEYIKAFGSTIVINPEKDKTMVQELLDFKDKVDHIIDICFLKNEKF 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE4 INAMKEAFETFINKRPNKPAELIAKYVDSKLRAGNKEATDEELEKMLDKIMIIFRFIYGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 INAMKEAFETFINKRPNKPAELIAKYVDSKLRAGNKEATDEELEKMLDKIMIIFRFIYGK 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE4 DVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMI 610 620 630 640 650 660 670 680 690 700 710 pF1KE4 QFKQ--YMQNQNVPGNIELTVNILTMGYWPTYVPMEVHLPPEMVKLQEIFKTFYLGKHSG :::: :::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QFKQVKYMQNQNVPGNIELTVNILTMGYWPTYVPMEVHLPPEMVKLQEIFKTFYLGKHSG 670 680 690 700 710 720 720 730 740 750 760 770 pF1KE4 RKLQWQSTIGHCVLKAEFKEGKKELQVSLFQTLVLLMFNEGEEFSLEEIKQATGIEDGEL ::::::::.::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 RKLQWQSTLGHCVLKAEFKEGKKELQVSLFQTLVLLMFNEGEEFSLEEIKQATGIEDGEL 730 740 750 760 770 780 780 790 800 810 820 830 pF1KE4 RRTLQSLACGKARVLAKNPKGKDIEDGDKFICNDDFKHKLFRIKINQIQMKETVEEQAST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 RRTLQSLACGKARVLAKNPKGKDIEDGDKFICNDDFKHKLFRIKINQIQMKETVEEQAST 790 800 810 820 830 840 840 850 860 870 880 890 pF1KE4 TERVFQDRQYQIDAAIVRIMKMRKTLSHNLLVSEVYNQLKFPVKPADLKKRIESLIDRDY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TERVFQDRQYQIDAAIVRIMKMRKTLSHNLLVSEVYNQLKFPVKPADLKKRIESLIDRDY 850 860 870 880 890 900 900 910 pF1KE4 MERDKENPNQYNYIA ::::::::::::::: XP_005 MERDKENPNQYNYIA 910 >>NP_001073341 (OMIM: 300304,300354) cullin-4B isoform 2 (895 aa) initn: 5715 init1: 5715 opt: 5715 Z-score: 4359.6 bits: 817.9 E(85289): 0 Smith-Waterman score: 5715; 99.9% identity (100.0% similar) in 891 aa overlap (23-913:5-895) 10 20 30 40 50 60 pF1KE4 MMSQSSGSGDGNDDEATTSKDGGFSSPSPSAAAAAQEVRSATDGNTSTTPPTSAKKRKLN :::::::::::::::::::::::::::::::::::::: NP_001 MFPTGFSSPSPSAAAAAQEVRSATDGNTSTTPPTSAKKRKLN 10 20 30 40 70 80 90 100 110 120 pF1KE4 SSSSSSSNSSNEREDFDSTSSSSSTPPLQPRDSASPSTSSFCLGVSVAASSHVPIQKKLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SSSSSSSNSSNEREDFDSTSSSSSTPPLQPRDSASPSTSSFCLGVSVAASSHVPIQKKLR 50 60 70 80 90 100 130 140 150 160 170 180 pF1KE4 FEDTLEFVGFDAKMAEESSSSSSSSSPTAATSQQQQLKNKSILISSVASVHHANGLAKSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FEDTLEFVGFDAKMAEESSSSSSSSSPTAATSQQQQLKNKSILISSVASVHHANGLAKSS 110 120 130 140 150 160 190 200 210 220 230 240 pF1KE4 TTVSSFANSKPGSAKKLVIKNFKDKPKLPENYTDETWQKLKEAVEAIQNSTSIKYNLEEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TTVSSFANSKPGSAKKLVIKNFKDKPKLPENYTDETWQKLKEAVEAIQNSTSIKYNLEEL 170 180 190 200 210 220 250 260 270 280 290 300 pF1KE4 YQAVENLCSYKISANLYKQLRQICEDHIKAQIHQFREDSLDSVLFLKKIDRCWQNHCRQM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YQAVENLCSYKISANLYKQLRQICEDHIKAQIHQFREDSLDSVLFLKKIDRCWQNHCRQM 230 240 250 260 270 280 310 320 330 340 350 360 pF1KE4 IMIRSIFLFLDRTYVLQNSMLPSIWDMGLELFRAHIISDQKVQNKTIDGILLLIERERNG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IMIRSIFLFLDRTYVLQNSMLPSIWDMGLELFRAHIISDQKVQNKTIDGILLLIERERNG 290 300 310 320 330 340 370 380 390 400 410 420 pF1KE4 EAIDRSLLRSLLSMLSDLQIYQDSFEQRFLEETNRLYAAEGQKLMQEREVPEYLHHVNKR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EAIDRSLLRSLLSMLSDLQIYQDSFEQRFLEETNRLYAAEGQKLMQEREVPEYLHHVNKR 350 360 370 380 390 400 430 440 450 460 470 480 pF1KE4 LEEEADRLITYLDQTTQKSLIATVEKQLLGEHLTAILQKGLNNLLDENRIQDLSLLYQLF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LEEEADRLITYLDQTTQKSLIATVEKQLLGEHLTAILQKGLNNLLDENRIQDLSLLYQLF 410 420 430 440 450 460 490 500 510 520 530 540 pF1KE4 SRVRGGVQVLLQQWIEYIKAFGSTIVINPEKDKTMVQELLDFKDKVDHIIDICFLKNEKF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SRVRGGVQVLLQQWIEYIKAFGSTIVINPEKDKTMVQELLDFKDKVDHIIDICFLKNEKF 470 480 490 500 510 520 550 560 570 580 590 600 pF1KE4 INAMKEAFETFINKRPNKPAELIAKYVDSKLRAGNKEATDEELEKMLDKIMIIFRFIYGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 INAMKEAFETFINKRPNKPAELIAKYVDSKLRAGNKEATDEELEKMLDKIMIIFRFIYGK 530 540 550 560 570 580 610 620 630 640 650 660 pF1KE4 DVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMI 590 600 610 620 630 640 670 680 690 700 710 720 pF1KE4 QFKQYMQNQNVPGNIELTVNILTMGYWPTYVPMEVHLPPEMVKLQEIFKTFYLGKHSGRK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QFKQYMQNQNVPGNIELTVNILTMGYWPTYVPMEVHLPPEMVKLQEIFKTFYLGKHSGRK 650 660 670 680 690 700 730 740 750 760 770 780 pF1KE4 LQWQSTIGHCVLKAEFKEGKKELQVSLFQTLVLLMFNEGEEFSLEEIKQATGIEDGELRR ::::::.::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LQWQSTLGHCVLKAEFKEGKKELQVSLFQTLVLLMFNEGEEFSLEEIKQATGIEDGELRR 710 720 730 740 750 760 790 800 810 820 830 840 pF1KE4 TLQSLACGKARVLAKNPKGKDIEDGDKFICNDDFKHKLFRIKINQIQMKETVEEQASTTE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TLQSLACGKARVLAKNPKGKDIEDGDKFICNDDFKHKLFRIKINQIQMKETVEEQASTTE 770 780 790 800 810 820 850 860 870 880 890 900 pF1KE4 RVFQDRQYQIDAAIVRIMKMRKTLSHNLLVSEVYNQLKFPVKPADLKKRIESLIDRDYME :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RVFQDRQYQIDAAIVRIMKMRKTLSHNLLVSEVYNQLKFPVKPADLKKRIESLIDRDYME 830 840 850 860 870 880 910 pF1KE4 RDKENPNQYNYIA ::::::::::::: NP_001 RDKENPNQYNYIA 890 >>NP_001317553 (OMIM: 300304,300354) cullin-4B isoform 3 (900 aa) initn: 5715 init1: 5715 opt: 5715 Z-score: 4359.6 bits: 817.9 E(85289): 0 Smith-Waterman score: 5715; 99.9% identity (100.0% similar) in 891 aa overlap (23-913:10-900) 10 20 30 40 50 60 pF1KE4 MMSQSSGSGDGNDDEATTSKDGGFSSPSPSAAAAAQEVRSATDGNTSTTPPTSAKKRKLN :::::::::::::::::::::::::::::::::::::: NP_001 MKSVCPVTSGFSSPSPSAAAAAQEVRSATDGNTSTTPPTSAKKRKLN 10 20 30 40 70 80 90 100 110 120 pF1KE4 SSSSSSSNSSNEREDFDSTSSSSSTPPLQPRDSASPSTSSFCLGVSVAASSHVPIQKKLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SSSSSSSNSSNEREDFDSTSSSSSTPPLQPRDSASPSTSSFCLGVSVAASSHVPIQKKLR 50 60 70 80 90 100 130 140 150 160 170 180 pF1KE4 FEDTLEFVGFDAKMAEESSSSSSSSSPTAATSQQQQLKNKSILISSVASVHHANGLAKSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FEDTLEFVGFDAKMAEESSSSSSSSSPTAATSQQQQLKNKSILISSVASVHHANGLAKSS 110 120 130 140 150 160 190 200 210 220 230 240 pF1KE4 TTVSSFANSKPGSAKKLVIKNFKDKPKLPENYTDETWQKLKEAVEAIQNSTSIKYNLEEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TTVSSFANSKPGSAKKLVIKNFKDKPKLPENYTDETWQKLKEAVEAIQNSTSIKYNLEEL 170 180 190 200 210 220 250 260 270 280 290 300 pF1KE4 YQAVENLCSYKISANLYKQLRQICEDHIKAQIHQFREDSLDSVLFLKKIDRCWQNHCRQM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YQAVENLCSYKISANLYKQLRQICEDHIKAQIHQFREDSLDSVLFLKKIDRCWQNHCRQM 230 240 250 260 270 280 310 320 330 340 350 360 pF1KE4 IMIRSIFLFLDRTYVLQNSMLPSIWDMGLELFRAHIISDQKVQNKTIDGILLLIERERNG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IMIRSIFLFLDRTYVLQNSMLPSIWDMGLELFRAHIISDQKVQNKTIDGILLLIERERNG 290 300 310 320 330 340 370 380 390 400 410 420 pF1KE4 EAIDRSLLRSLLSMLSDLQIYQDSFEQRFLEETNRLYAAEGQKLMQEREVPEYLHHVNKR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EAIDRSLLRSLLSMLSDLQIYQDSFEQRFLEETNRLYAAEGQKLMQEREVPEYLHHVNKR 350 360 370 380 390 400 430 440 450 460 470 480 pF1KE4 LEEEADRLITYLDQTTQKSLIATVEKQLLGEHLTAILQKGLNNLLDENRIQDLSLLYQLF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LEEEADRLITYLDQTTQKSLIATVEKQLLGEHLTAILQKGLNNLLDENRIQDLSLLYQLF 410 420 430 440 450 460 490 500 510 520 530 540 pF1KE4 SRVRGGVQVLLQQWIEYIKAFGSTIVINPEKDKTMVQELLDFKDKVDHIIDICFLKNEKF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SRVRGGVQVLLQQWIEYIKAFGSTIVINPEKDKTMVQELLDFKDKVDHIIDICFLKNEKF 470 480 490 500 510 520 550 560 570 580 590 600 pF1KE4 INAMKEAFETFINKRPNKPAELIAKYVDSKLRAGNKEATDEELEKMLDKIMIIFRFIYGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 INAMKEAFETFINKRPNKPAELIAKYVDSKLRAGNKEATDEELEKMLDKIMIIFRFIYGK 530 540 550 560 570 580 610 620 630 640 650 660 pF1KE4 DVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMI 590 600 610 620 630 640 670 680 690 700 710 720 pF1KE4 QFKQYMQNQNVPGNIELTVNILTMGYWPTYVPMEVHLPPEMVKLQEIFKTFYLGKHSGRK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QFKQYMQNQNVPGNIELTVNILTMGYWPTYVPMEVHLPPEMVKLQEIFKTFYLGKHSGRK 650 660 670 680 690 700 730 740 750 760 770 780 pF1KE4 LQWQSTIGHCVLKAEFKEGKKELQVSLFQTLVLLMFNEGEEFSLEEIKQATGIEDGELRR ::::::.::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LQWQSTLGHCVLKAEFKEGKKELQVSLFQTLVLLMFNEGEEFSLEEIKQATGIEDGELRR 710 720 730 740 750 760 790 800 810 820 830 840 pF1KE4 TLQSLACGKARVLAKNPKGKDIEDGDKFICNDDFKHKLFRIKINQIQMKETVEEQASTTE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TLQSLACGKARVLAKNPKGKDIEDGDKFICNDDFKHKLFRIKINQIQMKETVEEQASTTE 770 780 790 800 810 820 850 860 870 880 890 900 pF1KE4 RVFQDRQYQIDAAIVRIMKMRKTLSHNLLVSEVYNQLKFPVKPADLKKRIESLIDRDYME :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RVFQDRQYQIDAAIVRIMKMRKTLSHNLLVSEVYNQLKFPVKPADLKKRIESLIDRDYME 830 840 850 860 870 880 910 pF1KE4 RDKENPNQYNYIA ::::::::::::: NP_001 RDKENPNQYNYIA 890 900 >>XP_006724847 (OMIM: 300304,300354) PREDICTED: cullin-4 (902 aa) initn: 4085 init1: 4085 opt: 5701 Z-score: 4348.9 bits: 815.9 E(85289): 0 Smith-Waterman score: 5701; 99.7% identity (99.8% similar) in 893 aa overlap (23-913:10-902) 10 20 30 40 50 60 pF1KE4 MMSQSSGSGDGNDDEATTSKDGGFSSPSPSAAAAAQEVRSATDGNTSTTPPTSAKKRKLN :::::::::::::::::::::::::::::::::::::: XP_006 MKSVCPVTSGFSSPSPSAAAAAQEVRSATDGNTSTTPPTSAKKRKLN 10 20 30 40 70 80 90 100 110 120 pF1KE4 SSSSSSSNSSNEREDFDSTSSSSSTPPLQPRDSASPSTSSFCLGVSVAASSHVPIQKKLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 SSSSSSSNSSNEREDFDSTSSSSSTPPLQPRDSASPSTSSFCLGVSVAASSHVPIQKKLR 50 60 70 80 90 100 130 140 150 160 170 180 pF1KE4 FEDTLEFVGFDAKMAEESSSSSSSSSPTAATSQQQQLKNKSILISSVASVHHANGLAKSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 FEDTLEFVGFDAKMAEESSSSSSSSSPTAATSQQQQLKNKSILISSVASVHHANGLAKSS 110 120 130 140 150 160 190 200 210 220 230 240 pF1KE4 TTVSSFANSKPGSAKKLVIKNFKDKPKLPENYTDETWQKLKEAVEAIQNSTSIKYNLEEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 TTVSSFANSKPGSAKKLVIKNFKDKPKLPENYTDETWQKLKEAVEAIQNSTSIKYNLEEL 170 180 190 200 210 220 250 260 270 280 290 300 pF1KE4 YQAVENLCSYKISANLYKQLRQICEDHIKAQIHQFREDSLDSVLFLKKIDRCWQNHCRQM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 YQAVENLCSYKISANLYKQLRQICEDHIKAQIHQFREDSLDSVLFLKKIDRCWQNHCRQM 230 240 250 260 270 280 310 320 330 340 350 360 pF1KE4 IMIRSIFLFLDRTYVLQNSMLPSIWDMGLELFRAHIISDQKVQNKTIDGILLLIERERNG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 IMIRSIFLFLDRTYVLQNSMLPSIWDMGLELFRAHIISDQKVQNKTIDGILLLIERERNG 290 300 310 320 330 340 370 380 390 400 410 420 pF1KE4 EAIDRSLLRSLLSMLSDLQIYQDSFEQRFLEETNRLYAAEGQKLMQEREVPEYLHHVNKR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 EAIDRSLLRSLLSMLSDLQIYQDSFEQRFLEETNRLYAAEGQKLMQEREVPEYLHHVNKR 350 360 370 380 390 400 430 440 450 460 470 480 pF1KE4 LEEEADRLITYLDQTTQKSLIATVEKQLLGEHLTAILQKGLNNLLDENRIQDLSLLYQLF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LEEEADRLITYLDQTTQKSLIATVEKQLLGEHLTAILQKGLNNLLDENRIQDLSLLYQLF 410 420 430 440 450 460 490 500 510 520 530 540 pF1KE4 SRVRGGVQVLLQQWIEYIKAFGSTIVINPEKDKTMVQELLDFKDKVDHIIDICFLKNEKF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 SRVRGGVQVLLQQWIEYIKAFGSTIVINPEKDKTMVQELLDFKDKVDHIIDICFLKNEKF 470 480 490 500 510 520 550 560 570 580 590 600 pF1KE4 INAMKEAFETFINKRPNKPAELIAKYVDSKLRAGNKEATDEELEKMLDKIMIIFRFIYGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 INAMKEAFETFINKRPNKPAELIAKYVDSKLRAGNKEATDEELEKMLDKIMIIFRFIYGK 530 540 550 560 570 580 610 620 630 640 650 660 pF1KE4 DVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 DVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMI 590 600 610 620 630 640 670 680 690 700 710 pF1KE4 QFKQ--YMQNQNVPGNIELTVNILTMGYWPTYVPMEVHLPPEMVKLQEIFKTFYLGKHSG :::: :::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 QFKQVKYMQNQNVPGNIELTVNILTMGYWPTYVPMEVHLPPEMVKLQEIFKTFYLGKHSG 650 660 670 680 690 700 720 730 740 750 760 770 pF1KE4 RKLQWQSTIGHCVLKAEFKEGKKELQVSLFQTLVLLMFNEGEEFSLEEIKQATGIEDGEL ::::::::.::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 RKLQWQSTLGHCVLKAEFKEGKKELQVSLFQTLVLLMFNEGEEFSLEEIKQATGIEDGEL 710 720 730 740 750 760 780 790 800 810 820 830 pF1KE4 RRTLQSLACGKARVLAKNPKGKDIEDGDKFICNDDFKHKLFRIKINQIQMKETVEEQAST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 RRTLQSLACGKARVLAKNPKGKDIEDGDKFICNDDFKHKLFRIKINQIQMKETVEEQAST 770 780 790 800 810 820 840 850 860 870 880 890 pF1KE4 TERVFQDRQYQIDAAIVRIMKMRKTLSHNLLVSEVYNQLKFPVKPADLKKRIESLIDRDY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 TERVFQDRQYQIDAAIVRIMKMRKTLSHNLLVSEVYNQLKFPVKPADLKKRIESLIDRDY 830 840 850 860 870 880 900 910 pF1KE4 MERDKENPNQYNYIA ::::::::::::::: XP_006 MERDKENPNQYNYIA 890 900 >>XP_011529702 (OMIM: 300304,300354) PREDICTED: cullin-4 (717 aa) initn: 4618 init1: 4618 opt: 4620 Z-score: 3527.6 bits: 663.6 E(85289): 9.5e-190 Smith-Waterman score: 4620; 99.0% identity (99.6% similar) in 717 aa overlap (197-913:1-717) 170 180 190 200 210 220 pF1KE4 VASVHHANGLAKSSTTVSSFANSKPGSAKKLVIKNFKDKPKLPENYTDETWQKLKEAVEA .. .: ::::::::::::::::::::::: XP_011 MIDPDFADKPKLPENYTDETWQKLKEAVEA 10 20 30 230 240 250 260 270 280 pF1KE4 IQNSTSIKYNLEELYQAVENLCSYKISANLYKQLRQICEDHIKAQIHQFREDSLDSVLFL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IQNSTSIKYNLEELYQAVENLCSYKISANLYKQLRQICEDHIKAQIHQFREDSLDSVLFL 40 50 60 70 80 90 290 300 310 320 330 340 pF1KE4 KKIDRCWQNHCRQMIMIRSIFLFLDRTYVLQNSMLPSIWDMGLELFRAHIISDQKVQNKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KKIDRCWQNHCRQMIMIRSIFLFLDRTYVLQNSMLPSIWDMGLELFRAHIISDQKVQNKT 100 110 120 130 140 150 350 360 370 380 390 400 pF1KE4 IDGILLLIERERNGEAIDRSLLRSLLSMLSDLQIYQDSFEQRFLEETNRLYAAEGQKLMQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IDGILLLIERERNGEAIDRSLLRSLLSMLSDLQIYQDSFEQRFLEETNRLYAAEGQKLMQ 160 170 180 190 200 210 410 420 430 440 450 460 pF1KE4 EREVPEYLHHVNKRLEEEADRLITYLDQTTQKSLIATVEKQLLGEHLTAILQKGLNNLLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EREVPEYLHHVNKRLEEEADRLITYLDQTTQKSLIATVEKQLLGEHLTAILQKGLNNLLD 220 230 240 250 260 270 470 480 490 500 510 520 pF1KE4 ENRIQDLSLLYQLFSRVRGGVQVLLQQWIEYIKAFGSTIVINPEKDKTMVQELLDFKDKV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ENRIQDLSLLYQLFSRVRGGVQVLLQQWIEYIKAFGSTIVINPEKDKTMVQELLDFKDKV 280 290 300 310 320 330 530 540 550 560 570 580 pF1KE4 DHIIDICFLKNEKFINAMKEAFETFINKRPNKPAELIAKYVDSKLRAGNKEATDEELEKM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DHIIDICFLKNEKFINAMKEAFETFINKRPNKPAELIAKYVDSKLRAGNKEATDEELEKM 340 350 360 370 380 390 590 600 610 620 630 640 pF1KE4 LDKIMIIFRFIYGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LDKIMIIFRFIYGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLE 400 410 420 430 440 450 650 660 670 680 690 700 pF1KE4 GMFKDMELSKDIMIQFKQYMQNQNVPGNIELTVNILTMGYWPTYVPMEVHLPPEMVKLQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GMFKDMELSKDIMIQFKQYMQNQNVPGNIELTVNILTMGYWPTYVPMEVHLPPEMVKLQE 460 470 480 490 500 510 710 720 730 740 750 760 pF1KE4 IFKTFYLGKHSGRKLQWQSTIGHCVLKAEFKEGKKELQVSLFQTLVLLMFNEGEEFSLEE ::::::::::::::::::::.::::::::::::::::::::::::::::::::::::::: XP_011 IFKTFYLGKHSGRKLQWQSTLGHCVLKAEFKEGKKELQVSLFQTLVLLMFNEGEEFSLEE 520 530 540 550 560 570 770 780 790 800 810 820 pF1KE4 IKQATGIEDGELRRTLQSLACGKARVLAKNPKGKDIEDGDKFICNDDFKHKLFRIKINQI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IKQATGIEDGELRRTLQSLACGKARVLAKNPKGKDIEDGDKFICNDDFKHKLFRIKINQI 580 590 600 610 620 630 830 840 850 860 870 880 pF1KE4 QMKETVEEQASTTERVFQDRQYQIDAAIVRIMKMRKTLSHNLLVSEVYNQLKFPVKPADL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QMKETVEEQASTTERVFQDRQYQIDAAIVRIMKMRKTLSHNLLVSEVYNQLKFPVKPADL 640 650 660 670 680 690 890 900 910 pF1KE4 KKRIESLIDRDYMERDKENPNQYNYIA ::::::::::::::::::::::::::: XP_011 KKRIESLIDRDYMERDKENPNQYNYIA 700 710 >>XP_011529701 (OMIM: 300304,300354) PREDICTED: cullin-4 (719 aa) initn: 2988 init1: 2988 opt: 4606 Z-score: 3516.9 bits: 661.7 E(85289): 3.7e-189 Smith-Waterman score: 4606; 98.7% identity (99.3% similar) in 719 aa overlap (197-913:1-719) 170 180 190 200 210 220 pF1KE4 VASVHHANGLAKSSTTVSSFANSKPGSAKKLVIKNFKDKPKLPENYTDETWQKLKEAVEA .. .: ::::::::::::::::::::::: XP_011 MIDPDFADKPKLPENYTDETWQKLKEAVEA 10 20 30 230 240 250 260 270 280 pF1KE4 IQNSTSIKYNLEELYQAVENLCSYKISANLYKQLRQICEDHIKAQIHQFREDSLDSVLFL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IQNSTSIKYNLEELYQAVENLCSYKISANLYKQLRQICEDHIKAQIHQFREDSLDSVLFL 40 50 60 70 80 90 290 300 310 320 330 340 pF1KE4 KKIDRCWQNHCRQMIMIRSIFLFLDRTYVLQNSMLPSIWDMGLELFRAHIISDQKVQNKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KKIDRCWQNHCRQMIMIRSIFLFLDRTYVLQNSMLPSIWDMGLELFRAHIISDQKVQNKT 100 110 120 130 140 150 350 360 370 380 390 400 pF1KE4 IDGILLLIERERNGEAIDRSLLRSLLSMLSDLQIYQDSFEQRFLEETNRLYAAEGQKLMQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IDGILLLIERERNGEAIDRSLLRSLLSMLSDLQIYQDSFEQRFLEETNRLYAAEGQKLMQ 160 170 180 190 200 210 410 420 430 440 450 460 pF1KE4 EREVPEYLHHVNKRLEEEADRLITYLDQTTQKSLIATVEKQLLGEHLTAILQKGLNNLLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EREVPEYLHHVNKRLEEEADRLITYLDQTTQKSLIATVEKQLLGEHLTAILQKGLNNLLD 220 230 240 250 260 270 470 480 490 500 510 520 pF1KE4 ENRIQDLSLLYQLFSRVRGGVQVLLQQWIEYIKAFGSTIVINPEKDKTMVQELLDFKDKV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ENRIQDLSLLYQLFSRVRGGVQVLLQQWIEYIKAFGSTIVINPEKDKTMVQELLDFKDKV 280 290 300 310 320 330 530 540 550 560 570 580 pF1KE4 DHIIDICFLKNEKFINAMKEAFETFINKRPNKPAELIAKYVDSKLRAGNKEATDEELEKM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DHIIDICFLKNEKFINAMKEAFETFINKRPNKPAELIAKYVDSKLRAGNKEATDEELEKM 340 350 360 370 380 390 590 600 610 620 630 640 pF1KE4 LDKIMIIFRFIYGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LDKIMIIFRFIYGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLE 400 410 420 430 440 450 650 660 670 680 690 700 pF1KE4 GMFKDMELSKDIMIQFKQ--YMQNQNVPGNIELTVNILTMGYWPTYVPMEVHLPPEMVKL :::::::::::::::::: :::::::::::::::::::::::::::::::::::::::: XP_011 GMFKDMELSKDIMIQFKQVKYMQNQNVPGNIELTVNILTMGYWPTYVPMEVHLPPEMVKL 460 470 480 490 500 510 710 720 730 740 750 760 pF1KE4 QEIFKTFYLGKHSGRKLQWQSTIGHCVLKAEFKEGKKELQVSLFQTLVLLMFNEGEEFSL ::::::::::::::::::::::.::::::::::::::::::::::::::::::::::::: XP_011 QEIFKTFYLGKHSGRKLQWQSTLGHCVLKAEFKEGKKELQVSLFQTLVLLMFNEGEEFSL 520 530 540 550 560 570 770 780 790 800 810 820 pF1KE4 EEIKQATGIEDGELRRTLQSLACGKARVLAKNPKGKDIEDGDKFICNDDFKHKLFRIKIN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EEIKQATGIEDGELRRTLQSLACGKARVLAKNPKGKDIEDGDKFICNDDFKHKLFRIKIN 580 590 600 610 620 630 830 840 850 860 870 880 pF1KE4 QIQMKETVEEQASTTERVFQDRQYQIDAAIVRIMKMRKTLSHNLLVSEVYNQLKFPVKPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QIQMKETVEEQASTTERVFQDRQYQIDAAIVRIMKMRKTLSHNLLVSEVYNQLKFPVKPA 640 650 660 670 680 690 890 900 910 pF1KE4 DLKKRIESLIDRDYMERDKENPNQYNYIA ::::::::::::::::::::::::::::: XP_011 DLKKRIESLIDRDYMERDKENPNQYNYIA 700 710 >>XP_011529703 (OMIM: 300304,300354) PREDICTED: cullin-4 (701 aa) initn: 2728 init1: 2728 opt: 4346 Z-score: 3319.2 bits: 625.0 E(85289): 3.9e-178 Smith-Waterman score: 4346; 96.4% identity (98.0% similar) in 699 aa overlap (217-913:9-701) 190 200 210 220 230 240 pF1KE4 ANSKPGSAKKLVIKNFKDKPKLPENYTDETWQKLKEAVEAIQNSTSIKYNLEELYQAVEN : :.. . .. :.: . .. .:::: XP_011 MQILFMFLWIVLRKII--LRCSSSNR----RIKEAVEN 10 20 30 250 260 270 280 290 300 pF1KE4 LCSYKISANLYKQLRQICEDHIKAQIHQFREDSLDSVLFLKKIDRCWQNHCRQMIMIRSI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LCSYKISANLYKQLRQICEDHIKAQIHQFREDSLDSVLFLKKIDRCWQNHCRQMIMIRSI 40 50 60 70 80 90 310 320 330 340 350 360 pF1KE4 FLFLDRTYVLQNSMLPSIWDMGLELFRAHIISDQKVQNKTIDGILLLIERERNGEAIDRS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FLFLDRTYVLQNSMLPSIWDMGLELFRAHIISDQKVQNKTIDGILLLIERERNGEAIDRS 100 110 120 130 140 150 370 380 390 400 410 420 pF1KE4 LLRSLLSMLSDLQIYQDSFEQRFLEETNRLYAAEGQKLMQEREVPEYLHHVNKRLEEEAD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LLRSLLSMLSDLQIYQDSFEQRFLEETNRLYAAEGQKLMQEREVPEYLHHVNKRLEEEAD 160 170 180 190 200 210 430 440 450 460 470 480 pF1KE4 RLITYLDQTTQKSLIATVEKQLLGEHLTAILQKGLNNLLDENRIQDLSLLYQLFSRVRGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RLITYLDQTTQKSLIATVEKQLLGEHLTAILQKGLNNLLDENRIQDLSLLYQLFSRVRGG 220 230 240 250 260 270 490 500 510 520 530 540 pF1KE4 VQVLLQQWIEYIKAFGSTIVINPEKDKTMVQELLDFKDKVDHIIDICFLKNEKFINAMKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VQVLLQQWIEYIKAFGSTIVINPEKDKTMVQELLDFKDKVDHIIDICFLKNEKFINAMKE 280 290 300 310 320 330 550 560 570 580 590 600 pF1KE4 AFETFINKRPNKPAELIAKYVDSKLRAGNKEATDEELEKMLDKIMIIFRFIYGKDVFEAF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AFETFINKRPNKPAELIAKYVDSKLRAGNKEATDEELEKMLDKIMIIFRFIYGKDVFEAF 340 350 360 370 380 390 610 620 630 640 650 660 pF1KE4 YKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMIQFKQ-- :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 YKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMIQFKQVK 400 410 420 430 440 450 670 680 690 700 710 720 pF1KE4 YMQNQNVPGNIELTVNILTMGYWPTYVPMEVHLPPEMVKLQEIFKTFYLGKHSGRKLQWQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 YMQNQNVPGNIELTVNILTMGYWPTYVPMEVHLPPEMVKLQEIFKTFYLGKHSGRKLQWQ 460 470 480 490 500 510 730 740 750 760 770 780 pF1KE4 STIGHCVLKAEFKEGKKELQVSLFQTLVLLMFNEGEEFSLEEIKQATGIEDGELRRTLQS ::.::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 STLGHCVLKAEFKEGKKELQVSLFQTLVLLMFNEGEEFSLEEIKQATGIEDGELRRTLQS 520 530 540 550 560 570 790 800 810 820 830 840 pF1KE4 LACGKARVLAKNPKGKDIEDGDKFICNDDFKHKLFRIKINQIQMKETVEEQASTTERVFQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LACGKARVLAKNPKGKDIEDGDKFICNDDFKHKLFRIKINQIQMKETVEEQASTTERVFQ 580 590 600 610 620 630 850 860 870 880 890 900 pF1KE4 DRQYQIDAAIVRIMKMRKTLSHNLLVSEVYNQLKFPVKPADLKKRIESLIDRDYMERDKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DRQYQIDAAIVRIMKMRKTLSHNLLVSEVYNQLKFPVKPADLKKRIESLIDRDYMERDKE 640 650 660 670 680 690 910 pF1KE4 NPNQYNYIA ::::::::: XP_011 NPNQYNYIA 700 >>NP_001008895 (OMIM: 603137) cullin-4A isoform 1 [Homo (759 aa) initn: 4069 init1: 4069 opt: 4103 Z-score: 3133.6 bits: 590.8 E(85289): 8.4e-168 Smith-Waterman score: 4103; 82.6% identity (94.8% similar) in 749 aa overlap (168-913:13-759) 140 150 160 170 180 190 pF1KE4 SSSSSSSSSPTAATSQQQQLKNKSILISSVASVHHANGLAKSSTTVSSFANSKPGSA--- : : ..:::.: .. .. : .:::.: NP_001 MADEAPRKGSFSALVGRTNGLTKPAALAA--APAKPGGAGGS 10 20 30 40 200 210 220 230 240 250 pF1KE4 KKLVIKNFKDKPKLPENYTDETWQKLKEAVEAIQNSTSIKYNLEELYQAVENLCSYKISA ::::::::.:.:.::.:::..::.::.:::.:.:.::::.:::::::::::::::.:.: NP_001 KKLVIKNFRDRPRLPDNYTQDTWRKLHEAVRAVQSSTSIRYNLEELYQAVENLCSHKVSP 50 60 70 80 90 100 260 270 280 290 300 310 pF1KE4 NLYKQLRQICEDHIKAQIHQFREDSLDSVLFLKKIDRCWQNHCRQMIMIRSIFLFLDRTY ::::::: ::::..::: :::::::::::::::. :::.::::::::::::::::::: NP_001 MLYKQLRQACEDHVQAQILPFREDSLDSVLFLKKINTCWQDHCRQMIMIRSIFLFLDRTY 110 120 130 140 150 160 320 330 340 350 360 370 pF1KE4 VLQNSMLPSIWDMGLELFRAHIISDQKVQNKTIDGILLLIERERNGEAIDRSLLRSLLSM ::::: :::::::::::::.:::::. ::.::::::::::::::.:::.:::::::::.: NP_001 VLQNSTLPSIWDMGLELFRTHIISDKMVQSKTIDGILLLIERERSGEAVDRSLLRSLLGM 170 180 190 200 210 220 380 390 400 410 420 430 pF1KE4 LSDLQIYQDSFEQRFLEETNRLYAAEGQKLMQEREVPEYLHHVNKRLEEEADRLITYLDQ :::::.:.:::: .:::::: :::::::.:::::::::::.::.::::::.::.:::::. NP_001 LSDLQVYKDSFELKFLEETNCLYAAEGQRLMQEREVPEYLNHVSKRLEEEGDRVITYLDH 230 240 250 260 270 280 440 450 460 470 480 490 pF1KE4 TTQKSLIATVEKQLLGEHLTAILQKGLNNLLDENRIQDLSLLYQLFSRVRGGVQVLLQQW .::: ::: ::::::::::::::::::..::::::. ::. .:::::::::: :.:::.: NP_001 STQKPLIACVEKQLLGEHLTAILQKGLDHLLDENRVPDLAQMYQLFSRVRGGQQALLQHW 290 300 310 320 330 340 500 510 520 530 540 550 pF1KE4 IEYIKAFGSTIVINPEKDKTMVQELLDFKDKVDHIIDICFLKNEKFINAMKEAFETFINK ::::.::..::::::::: :::.::::::::::.:..:: :::.:.: :::.::::::: NP_001 SEYIKTFGTAIVINPEKDKDMVQDLLDFKDKVDHVIEVCFQKNERFVNLMKESFETFINK 350 360 370 380 390 400 560 570 580 590 600 610 pF1KE4 RPNKPAELIAKYVDSKLRAGNKEATDEELEKMLDKIMIIFRFIYGKDVFEAFYKKDLAKR :::::::::::.::::::::::::::::::. ::::::.::::.:::::::::::::::: NP_001 RPNKPAELIAKHVDSKLRAGNKEATDEELERTLDKIMILFRFIHGKDVFEAFYKKDLAKR 410 420 430 440 450 460 620 630 640 650 660 670 pF1KE4 LLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMIQFKQYMQNQNVPGN :::::::::::::::::::::::::::::::::::::::::::::..:::.::::. : NP_001 LLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMVHFKQHMQNQSDSGP 470 480 490 500 510 520 680 690 700 710 720 730 pF1KE4 IELTVNILTMGYWPTYVPMEVHLPPEMVKLQEIFKTFYLGKHSGRKLQWQSTIGHCVLKA :.::::::::::::::.:::::: :::.::::.::.::::::::::::::.:.:: :::: NP_001 IDLTVNILTMGYWPTYTPMEVHLTPEMIKLQEVFKAFYLGKHSGRKLQWQTTLGHAVLKA 530 540 550 560 570 580 740 750 760 770 780 790 pF1KE4 EFKEGKKELQVSLFQTLVLLMFNEGEEFSLEEIKQATGIEDGELRRTLQSLACGKARVLA ::::::::.::::::::::::::::. ::.::::.::::::.::::::::::::::::: NP_001 EFKEGKKEFQVSLFQTLVLLMFNEGDGFSFEEIKMATGIEDSELRRTLQSLACGKARVLI 590 600 610 620 630 640 800 810 820 830 840 850 pF1KE4 KNPKGKDIEDGDKFICNDDFKHKLFRIKINQIQMKETVEEQASTTERVFQDRQYQIDAAI :.::::..::::::: : .::::::::::::::::::::::.:::::::::::::::::: NP_001 KSPKGKEVEDGDKFIFNGEFKHKLFRIKINQIQMKETVEEQVSTTERVFQDRQYQIDAAI 650 660 670 680 690 700 860 870 880 890 900 910 pF1KE4 VRIMKMRKTLSHNLLVSEVYNQLKFPVKPADLKKRIESLIDRDYMERDKENPNQYNYIA ::::::::::.:::::::.::::::::::.:::::::::::::::::::.:::::.:.: NP_001 VRIMKMRKTLGHNLLVSELYNQLKFPVKPGDLKKRIESLIDRDYMERDKDNPNQYHYVA 710 720 730 740 750 >>NP_003580 (OMIM: 603137) cullin-4A isoform 2 [Homo sap (659 aa) initn: 3755 init1: 3755 opt: 3755 Z-score: 2869.7 bits: 541.8 E(85289): 4.2e-153 Smith-Waterman score: 3755; 85.6% identity (95.9% similar) in 658 aa overlap (256-913:2-659) 230 240 250 260 270 280 pF1KE4 AIQNSTSIKYNLEELYQAVENLCSYKISANLYKQLRQICEDHIKAQIHQFREDSLDSVLF ::::::: ::::..::: ::::::::::: NP_003 MLYKQLRQACEDHVQAQILPFREDSLDSVLF 10 20 30 290 300 310 320 330 340 pF1KE4 LKKIDRCWQNHCRQMIMIRSIFLFLDRTYVLQNSMLPSIWDMGLELFRAHIISDQKVQNK ::::. :::.:::::::::::::::::::::::: :::::::::::::.:::::. ::.: NP_003 LKKINTCWQDHCRQMIMIRSIFLFLDRTYVLQNSTLPSIWDMGLELFRTHIISDKMVQSK 40 50 60 70 80 90 350 360 370 380 390 400 pF1KE4 TIDGILLLIERERNGEAIDRSLLRSLLSMLSDLQIYQDSFEQRFLEETNRLYAAEGQKLM :::::::::::::.:::.:::::::::.::::::.:.:::: .:::::: :::::::.:: NP_003 TIDGILLLIERERSGEAVDRSLLRSLLGMLSDLQVYKDSFELKFLEETNCLYAAEGQRLM 100 110 120 130 140 150 410 420 430 440 450 460 pF1KE4 QEREVPEYLHHVNKRLEEEADRLITYLDQTTQKSLIATVEKQLLGEHLTAILQKGLNNLL :::::::::.::.::::::.::.:::::..::: ::: ::::::::::::::::::..:: NP_003 QEREVPEYLNHVSKRLEEEGDRVITYLDHSTQKPLIACVEKQLLGEHLTAILQKGLDHLL 160 170 180 190 200 210 470 480 490 500 510 520 pF1KE4 DENRIQDLSLLYQLFSRVRGGVQVLLQQWIEYIKAFGSTIVINPEKDKTMVQELLDFKDK ::::. ::. .:::::::::: :.:::.: ::::.::..::::::::: :::.::::::: NP_003 DENRVPDLAQMYQLFSRVRGGQQALLQHWSEYIKTFGTAIVINPEKDKDMVQDLLDFKDK 220 230 240 250 260 270 530 540 550 560 570 580 pF1KE4 VDHIIDICFLKNEKFINAMKEAFETFINKRPNKPAELIAKYVDSKLRAGNKEATDEELEK :::.:..:: :::.:.: :::.::::::::::::::::::.::::::::::::::::::. NP_003 VDHVIEVCFQKNERFVNLMKESFETFINKRPNKPAELIAKHVDSKLRAGNKEATDEELER 280 290 300 310 320 330 590 600 610 620 630 640 pF1KE4 MLDKIMIIFRFIYGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKL ::::::.::::.::::::::::::::::::::::::::::::::::::::::::::::: NP_003 TLDKIMILFRFIHGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKL 340 350 360 370 380 390 650 660 670 680 690 700 pF1KE4 EGMFKDMELSKDIMIQFKQYMQNQNVPGNIELTVNILTMGYWPTYVPMEVHLPPEMVKLQ ::::::::::::::..:::.::::. : :.::::::::::::::.:::::: :::.::: NP_003 EGMFKDMELSKDIMVHFKQHMQNQSDSGPIDLTVNILTMGYWPTYTPMEVHLTPEMIKLQ 400 410 420 430 440 450 710 720 730 740 750 760 pF1KE4 EIFKTFYLGKHSGRKLQWQSTIGHCVLKAEFKEGKKELQVSLFQTLVLLMFNEGEEFSLE :.::.::::::::::::::.:.:: ::::::::::::.::::::::::::::::. ::.: NP_003 EVFKAFYLGKHSGRKLQWQTTLGHAVLKAEFKEGKKEFQVSLFQTLVLLMFNEGDGFSFE 460 470 480 490 500 510 770 780 790 800 810 820 pF1KE4 EIKQATGIEDGELRRTLQSLACGKARVLAKNPKGKDIEDGDKFICNDDFKHKLFRIKINQ :::.::::::.::::::::::::::::: :.::::..::::::: : .:::::::::::: NP_003 EIKMATGIEDSELRRTLQSLACGKARVLIKSPKGKEVEDGDKFIFNGEFKHKLFRIKINQ 520 530 540 550 560 570 830 840 850 860 870 880 pF1KE4 IQMKETVEEQASTTERVFQDRQYQIDAAIVRIMKMRKTLSHNLLVSEVYNQLKFPVKPAD ::::::::::.::::::::::::::::::::::::::::.:::::::.::::::::::.: NP_003 IQMKETVEEQVSTTERVFQDRQYQIDAAIVRIMKMRKTLGHNLLVSELYNQLKFPVKPGD 580 590 600 610 620 630 890 900 910 pF1KE4 LKKRIESLIDRDYMERDKENPNQYNYIA ::::::::::::::::::.:::::.:.: NP_003 LKKRIESLIDRDYMERDKDNPNQYHYVA 640 650 913 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Mon Nov 7 16:57:56 2016 done: Mon Nov 7 16:57:58 2016 Total Scan time: 13.040 Total Display time: 0.230 Function used was FASTA [36.3.4 Apr, 2011]