FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE2179, 281 aa 1>>>pF1KE2179 281 - 281 aa - 281 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.5266+/-0.000389; mu= 13.8952+/- 0.024 mean_var=69.7355+/-14.070, 0's: 0 Z-trim(112.1): 38 B-trim: 18 in 1/50 Lambda= 0.153584 statistics sampled from 20907 (20941) to 20907 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.631), E-opt: 0.2 (0.246), width: 16 Scan time: 6.680 The best scores are: opt bits E(85289) NP_003801 (OMIM: 603598) tumor necrosis factor lig ( 281) 1876 424.8 8.8e-119 NP_001177871 (OMIM: 603598) tumor necrosis factor ( 101) 622 146.7 1.6e-35 NP_003692 (OMIM: 259710,602642) tumor necrosis fac ( 317) 318 79.6 8.1e-15 XP_016876292 (OMIM: 259710,602642) PREDICTED: tumo ( 244) 296 74.7 1.9e-13 XP_011533582 (OMIM: 259710,602642) PREDICTED: tumo ( 244) 296 74.7 1.9e-13 NP_143026 (OMIM: 259710,602642) tumor necrosis fac ( 244) 296 74.7 1.9e-13 XP_016876291 (OMIM: 259710,602642) PREDICTED: tumo ( 263) 296 74.7 2e-13 NP_001177872 (OMIM: 603598) tumor necrosis factor ( 65) 282 71.3 5.3e-13 NP_001191273 (OMIM: 604052) tumor necrosis factor ( 192) 222 58.3 1.3e-08 NP_005109 (OMIM: 604052) tumor necrosis factor lig ( 251) 217 57.2 3.6e-08 NP_000630 (OMIM: 134638,211980,601859) tumor necro ( 281) 209 55.5 1.4e-07 NP_742011 (OMIM: 604520) tumor necrosis factor lig ( 204) 189 51.0 2.2e-06 XP_016882906 (OMIM: 604520) PREDICTED: tumor necro ( 240) 189 51.0 2.6e-06 NP_003798 (OMIM: 604520) tumor necrosis factor lig ( 240) 189 51.0 2.6e-06 NP_000585 (OMIM: 157300,191160,600807,611162) tumo ( 233) 153 43.0 0.00063 NP_000065 (OMIM: 300386,308230) CD40 ligand [Homo ( 261) 139 39.9 0.006 >>NP_003801 (OMIM: 603598) tumor necrosis factor ligand (281 aa) initn: 1876 init1: 1876 opt: 1876 Z-score: 2253.5 bits: 424.8 E(85289): 8.8e-119 Smith-Waterman score: 1876; 100.0% identity (100.0% similar) in 281 aa overlap (1-281:1-281) 10 20 30 40 50 60 pF1KE2 MAMMEVQGGPSLGQTCVLIVIFTVLLQSLCVAVTYVYFTNELKQMQDKYSKSGIACFLKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 MAMMEVQGGPSLGQTCVLIVIFTVLLQSLCVAVTYVYFTNELKQMQDKYSKSGIACFLKE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 DDSYWDPNDEESMNSPCWQVKWQLRQLVRKMILRTSEETISTVQEKQQNISPLVRERGPQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 DDSYWDPNDEESMNSPCWQVKWQLRQLVRKMILRTSEETISTVQEKQQNISPLVRERGPQ 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 RVAAHITGTRGRSNTLSSPNSKNEKALGRKINSWESSRSGHSFLSNLHLRNGELVIHEKG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 RVAAHITGTRGRSNTLSSPNSKNEKALGRKINSWESSRSGHSFLSNLHLRNGELVIHEKG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 FYYIYSQTYFRFQEEIKENTKNDKQMVQYIYKYTSYPDPILLMKSARNSCWSKDAEYGLY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 FYYIYSQTYFRFQEEIKENTKNDKQMVQYIYKYTSYPDPILLMKSARNSCWSKDAEYGLY 190 200 210 220 230 240 250 260 270 280 pF1KE2 SIYQGGIFELKENDRIFVSVTNEHLIDMDHEASFFGAFLVG ::::::::::::::::::::::::::::::::::::::::: NP_003 SIYQGGIFELKENDRIFVSVTNEHLIDMDHEASFFGAFLVG 250 260 270 280 >>NP_001177871 (OMIM: 603598) tumor necrosis factor liga (101 aa) initn: 675 init1: 622 opt: 622 Z-score: 758.6 bits: 146.7 E(85289): 1.6e-35 Smith-Waterman score: 622; 100.0% identity (100.0% similar) in 90 aa overlap (1-90:1-90) 10 20 30 40 50 60 pF1KE2 MAMMEVQGGPSLGQTCVLIVIFTVLLQSLCVAVTYVYFTNELKQMQDKYSKSGIACFLKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MAMMEVQGGPSLGQTCVLIVIFTVLLQSLCVAVTYVYFTNELKQMQDKYSKSGIACFLKE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 DDSYWDPNDEESMNSPCWQVKWQLRQLVRKMILRTSEETISTVQEKQQNISPLVRERGPQ :::::::::::::::::::::::::::::: NP_001 DDSYWDPNDEESMNSPCWQVKWQLRQLVRKTPRMKRLWAAK 70 80 90 100 >>NP_003692 (OMIM: 259710,602642) tumor necrosis factor (317 aa) initn: 269 init1: 179 opt: 318 Z-score: 387.0 bits: 79.6 E(85289): 8.1e-15 Smith-Waterman score: 328; 25.4% identity (58.5% similar) in 284 aa overlap (10-280:42-313) 10 20 30 pF1KE2 MAMMEVQGGPSLGQTCVLIVIFTVLLQSLCVAVTYVYFT :. ... . .. : : .: .. . :: NP_003 LRGSEEMGGGPGAPHEGPLHAPPPPAPHQPPAASRSMFVALLGLGLGQVVCSVALFFYFR 20 30 40 50 60 70 40 50 60 70 80 90 pF1KE2 NELKQMQDKYSKSGIACF-----LKEDDSYWDPN----DEESMNSPCWQVKWQLRQLVRK .. .. :..: :. :.:. .. : . : . . . : ..: .. :.: NP_003 AQMDP--NRISEDGTHCIYRILRLHENADFQDTTLESQDTKLIPDSCRRIKQAFQGAVQK 80 90 100 110 120 100 110 120 130 140 pF1KE2 MILRTSEETISTVQEKQQNISPL---VRERGPQRVAAHITGTRGRSNTLSSPNSKNEKAL . . ... . . : : : . . ::.: :. . :..... .: NP_003 ELQHIVGSQHIRAEKAMVDGSWLDLAKRSKLEAQPFAHLT-----INATDIPSGSHKVSL 130 140 150 160 170 180 150 160 170 180 190 200 pF1KE2 GRKINSWESSRSGHSFLSNLHLRNGELVIHEKGFYYIYSQTYFRFQEEIKENTKNDKQMV .:: .: : . .::. . ::.:.... ::::.:.. :: .: . . . :.. NP_003 ----SSWYHDR-GWAKISNMTFSNGKLIVNQDGFYYLYANICFRHHETSGDLATEYLQLM 190 200 210 220 230 210 220 230 240 250 260 pF1KE2 QYIYKYT-SYPDPILLMKSARNSCWSKDAEYGLYSIYQGGIFELKENDRIFVSVTNEHLI :. : . . :. :::.. .. :: ..:. .::: ::.:.:. ...: . :.: :. NP_003 VYVTKTSIKIPSSHTLMKGGSTKYWSGNSEFHFYSINVGGFFKLRSGEEISIEVSNPSLL 240 250 260 270 280 290 270 280 pF1KE2 DMDHEASFFGAFLVG : :..:..:::: : NP_003 DPDQDATYFGAFKVRDID 300 310 >>XP_016876292 (OMIM: 259710,602642) PREDICTED: tumor ne (244 aa) initn: 269 init1: 179 opt: 296 Z-score: 362.4 bits: 74.7 E(85289): 1.9e-13 Smith-Waterman score: 302; 26.7% identity (59.5% similar) in 247 aa overlap (47-280:4-240) 20 30 40 50 60 pF1KE2 VLIVIFTVLLQSLCVAVTYVYFTNELKQMQDKYSKSGIACF-----LKEDDSYWDPN--- .. :..: :. :.:. .. : . XP_016 MDPNRISEDGTHCIYRILRLHENADFQDTTLES 10 20 30 70 80 90 100 110 120 pF1KE2 -DEESMNSPCWQVKWQLRQLVRKMILRTSEETISTVQEKQQNISPL---VRERGPQRVAA : . . . : ..: .. :.: . . ... . . : : : . . : XP_016 QDTKLIPDSCRRIKQAFQGAVQKELQHIVGSQHIRAEKAMVDGSWLDLAKRSKLEAQPFA 40 50 60 70 80 90 130 140 150 160 170 180 pF1KE2 HITGTRGRSNTLSSPNSKNEKALGRKINSWESSRSGHSFLSNLHLRNGELVIHEKGFYYI :.: :. . :..... .: .:: .: : . .::. . ::.:.... ::::. XP_016 HLT-----INATDIPSGSHKVSL----SSWYHDR-GWAKISNMTFSNGKLIVNQDGFYYL 100 110 120 130 140 190 200 210 220 230 240 pF1KE2 YSQTYFRFQEEIKENTKNDKQMVQYIYKYT-SYPDPILLMKSARNSCWSKDAEYGLYSIY :.. :: .: . . . :.. :. : . . :. :::.. .. :: ..:. .::: XP_016 YANICFRHHETSGDLATEYLQLMVYVTKTSIKIPSSHTLMKGGSTKYWSGNSEFHFYSIN 150 160 170 180 190 200 250 260 270 280 pF1KE2 QGGIFELKENDRIFVSVTNEHLIDMDHEASFFGAFLVG ::.:.:. ...: . :.: :.: :..:..:::: : XP_016 VGGFFKLRSGEEISIEVSNPSLLDPDQDATYFGAFKVRDID 210 220 230 240 >>XP_011533582 (OMIM: 259710,602642) PREDICTED: tumor ne (244 aa) initn: 269 init1: 179 opt: 296 Z-score: 362.4 bits: 74.7 E(85289): 1.9e-13 Smith-Waterman score: 302; 26.7% identity (59.5% similar) in 247 aa overlap (47-280:4-240) 20 30 40 50 60 pF1KE2 VLIVIFTVLLQSLCVAVTYVYFTNELKQMQDKYSKSGIACF-----LKEDDSYWDPN--- .. :..: :. :.:. .. : . XP_011 MDPNRISEDGTHCIYRILRLHENADFQDTTLES 10 20 30 70 80 90 100 110 120 pF1KE2 -DEESMNSPCWQVKWQLRQLVRKMILRTSEETISTVQEKQQNISPL---VRERGPQRVAA : . . . : ..: .. :.: . . ... . . : : : . . : XP_011 QDTKLIPDSCRRIKQAFQGAVQKELQHIVGSQHIRAEKAMVDGSWLDLAKRSKLEAQPFA 40 50 60 70 80 90 130 140 150 160 170 180 pF1KE2 HITGTRGRSNTLSSPNSKNEKALGRKINSWESSRSGHSFLSNLHLRNGELVIHEKGFYYI :.: :. . :..... .: .:: .: : . .::. . ::.:.... ::::. XP_011 HLT-----INATDIPSGSHKVSL----SSWYHDR-GWAKISNMTFSNGKLIVNQDGFYYL 100 110 120 130 140 190 200 210 220 230 240 pF1KE2 YSQTYFRFQEEIKENTKNDKQMVQYIYKYT-SYPDPILLMKSARNSCWSKDAEYGLYSIY :.. :: .: . . . :.. :. : . . :. :::.. .. :: ..:. .::: XP_011 YANICFRHHETSGDLATEYLQLMVYVTKTSIKIPSSHTLMKGGSTKYWSGNSEFHFYSIN 150 160 170 180 190 200 250 260 270 280 pF1KE2 QGGIFELKENDRIFVSVTNEHLIDMDHEASFFGAFLVG ::.:.:. ...: . :.: :.: :..:..:::: : XP_011 VGGFFKLRSGEEISIEVSNPSLLDPDQDATYFGAFKVRDID 210 220 230 240 >>NP_143026 (OMIM: 259710,602642) tumor necrosis factor (244 aa) initn: 269 init1: 179 opt: 296 Z-score: 362.4 bits: 74.7 E(85289): 1.9e-13 Smith-Waterman score: 302; 26.7% identity (59.5% similar) in 247 aa overlap (47-280:4-240) 20 30 40 50 60 pF1KE2 VLIVIFTVLLQSLCVAVTYVYFTNELKQMQDKYSKSGIACF-----LKEDDSYWDPN--- .. :..: :. :.:. .. : . NP_143 MDPNRISEDGTHCIYRILRLHENADFQDTTLES 10 20 30 70 80 90 100 110 120 pF1KE2 -DEESMNSPCWQVKWQLRQLVRKMILRTSEETISTVQEKQQNISPL---VRERGPQRVAA : . . . : ..: .. :.: . . ... . . : : : . . : NP_143 QDTKLIPDSCRRIKQAFQGAVQKELQHIVGSQHIRAEKAMVDGSWLDLAKRSKLEAQPFA 40 50 60 70 80 90 130 140 150 160 170 180 pF1KE2 HITGTRGRSNTLSSPNSKNEKALGRKINSWESSRSGHSFLSNLHLRNGELVIHEKGFYYI :.: :. . :..... .: .:: .: : . .::. . ::.:.... ::::. NP_143 HLT-----INATDIPSGSHKVSL----SSWYHDR-GWAKISNMTFSNGKLIVNQDGFYYL 100 110 120 130 140 190 200 210 220 230 240 pF1KE2 YSQTYFRFQEEIKENTKNDKQMVQYIYKYT-SYPDPILLMKSARNSCWSKDAEYGLYSIY :.. :: .: . . . :.. :. : . . :. :::.. .. :: ..:. .::: NP_143 YANICFRHHETSGDLATEYLQLMVYVTKTSIKIPSSHTLMKGGSTKYWSGNSEFHFYSIN 150 160 170 180 190 200 250 260 270 280 pF1KE2 QGGIFELKENDRIFVSVTNEHLIDMDHEASFFGAFLVG ::.:.:. ...: . :.: :.: :..:..:::: : NP_143 VGGFFKLRSGEEISIEVSNPSLLDPDQDATYFGAFKVRDID 210 220 230 240 >>XP_016876291 (OMIM: 259710,602642) PREDICTED: tumor ne (263 aa) initn: 269 init1: 179 opt: 296 Z-score: 361.9 bits: 74.7 E(85289): 2e-13 Smith-Waterman score: 303; 26.6% identity (59.5% similar) in 252 aa overlap (42-280:18-259) 20 30 40 50 60 pF1KE2 LGQTCVLIVIFTVLLQSLCVAVTYVYFTNELKQMQDKYSKSGIACF-----LKEDDSYWD :.. .. :..: :. :.:. .. : XP_016 MRGSTKKTDDTSDFKFCLEMDPNRISEDGTHCIYRILRLHENADFQD 10 20 30 40 70 80 90 100 110 pF1KE2 PN----DEESMNSPCWQVKWQLRQLVRKMILRTSEETISTVQEKQQNISPL---VRERGP . : . . . : ..: .. :.: . . ... . . : : : . XP_016 TTLESQDTKLIPDSCRRIKQAFQGAVQKELQHIVGSQHIRAEKAMVDGSWLDLAKRSKLE 50 60 70 80 90 100 120 130 140 150 160 170 pF1KE2 QRVAAHITGTRGRSNTLSSPNSKNEKALGRKINSWESSRSGHSFLSNLHLRNGELVIHEK . ::.: :. . :..... .: .:: .: : . .::. . ::.:.... XP_016 AQPFAHLT-----INATDIPSGSHKVSL----SSWYHDR-GWAKISNMTFSNGKLIVNQD 110 120 130 140 150 180 190 200 210 220 230 pF1KE2 GFYYIYSQTYFRFQEEIKENTKNDKQMVQYIYKYT-SYPDPILLMKSARNSCWSKDAEYG ::::.:.. :: .: . . . :.. :. : . . :. :::.. .. :: ..:. XP_016 GFYYLYANICFRHHETSGDLATEYLQLMVYVTKTSIKIPSSHTLMKGGSTKYWSGNSEFH 160 170 180 190 200 210 240 250 260 270 280 pF1KE2 LYSIYQGGIFELKENDRIFVSVTNEHLIDMDHEASFFGAFLVG .::: ::.:.:. ...: . :.: :.: :..:..:::: : XP_016 FYSINVGGFFKLRSGEEISIEVSNPSLLDPDQDATYFGAFKVRDID 220 230 240 250 260 >>NP_001177872 (OMIM: 603598) tumor necrosis factor liga (65 aa) initn: 318 init1: 282 opt: 282 Z-score: 354.4 bits: 71.3 E(85289): 5.3e-13 Smith-Waterman score: 282; 93.6% identity (97.9% similar) in 47 aa overlap (1-47:1-47) 10 20 30 40 50 60 pF1KE2 MAMMEVQGGPSLGQTCVLIVIFTVLLQSLCVAVTYVYFTNELKQMQDKYSKSGIACFLKE ::::::::::::::::::::::::::::::::::::::::::::. . NP_001 MAMMEVQGGPSLGQTCVLIVIFTVLLQSLCVAVTYVYFTNELKQFAENDCQRLMSGQQTG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 DDSYWDPNDEESMNSPCWQVKWQLRQLVRKMILRTSEETISTVQEKQQNISPLVRERGPQ NP_001 SLLPS >>NP_001191273 (OMIM: 604052) tumor necrosis factor liga (192 aa) initn: 158 init1: 74 opt: 222 Z-score: 275.4 bits: 58.3 E(85289): 1.3e-08 Smith-Waterman score: 222; 32.4% identity (59.6% similar) in 188 aa overlap (108-280:18-192) 80 90 100 110 120 130 pF1KE2 WQVKWQLRQLVRKMILRTSEETISTVQEKQQNISPLVRERGPQRVA-----AHITGTRGR ..:::.: . .: :. ::.: .: NP_001 MQLTKGRLHFSHPLSHTKHISPFVTD-APLRADGDKPRAHLTVVR-- 10 20 30 40 140 150 160 170 180 190 pF1KE2 SNTLSSPNSKNE-KALGRKINSWESSRSGHSFLSN-LHLRNGELVIHEKGFYYIYSQTYF . . ::. :: :: . : .: .: .. : :.: :.: :.::::. : NP_001 --QTPTQHFKNQFPAL-----HWEH-ELGLAFTKNRMNYTNKFLLIPESGDYFIYSQVTF 50 60 70 80 90 200 210 220 230 240 pF1KE2 RFQE----EIKENTKNDK--QMVQYIYKYT-SYPDPILLMKSARNSCWSKDAEYGLYSIY : . ::.. . .: ... : : : :::.: :. .... : . . :: NP_001 RGMTSECSEIRQAGRPNKPDSITVVITKVTDSYPEPTQLLMGTKSVCEVGSNWF--QPIY 100 110 120 130 140 150 250 260 270 280 pF1KE2 QGGIFELKENDRIFVSVTNEHLIDMDHE-ASFFGAFLVG :..: :.:.:...:.:.. :.:. .: .::::::. NP_001 LGAMFSLQEGDKLMVNVSDISLVDYTKEDKTFFGAFLL 160 170 180 190 >>NP_005109 (OMIM: 604052) tumor necrosis factor ligand (251 aa) initn: 142 init1: 74 opt: 217 Z-score: 267.6 bits: 57.2 E(85289): 3.6e-08 Smith-Waterman score: 225; 31.6% identity (58.5% similar) in 212 aa overlap (79-280:58-251) 50 60 70 80 90 100 pF1KE2 YSKSGIACFLKEDDSYWDPNDEESMNSPCWQVKWQLRQLVRKMILRTSEETISTVQEKQQ :.. : . :. . :. .: . : .:: NP_005 ARSSSARWALTCCLVLLPFLAGLTTYLLVSQLRAQGEACVQFQALKGQEFAPS----HQQ 30 40 50 60 70 80 110 120 130 140 150 160 pF1KE2 NISPLVRERGPQRVAAHITGTRGRSNTLSSPNSKNE-KALGRKINSWESSRSGHSFLSN- .:: : : .. ::.: .: . . ::. :: :: . : .: .: NP_005 VYAPL-RADG-DKPRAHLTVVR----QTPTQHFKNQFPAL-----HWEH-ELGLAFTKNR 90 100 110 120 130 170 180 190 200 210 pF1KE2 LHLRNGELVIHEKGFYYIYSQTYFRFQE----EIKENTKNDK--QMVQYIYKYT-SYPDP .. : :.: :.: :.::::. :: . ::.. . .: ... : : : :::.: NP_005 MNYTNKFLLIPESGDYFIYSQVTFRGMTSECSEIRQAGRPNKPDSITVVITKVTDSYPEP 140 150 160 170 180 190 220 230 240 250 260 270 pF1KE2 ILLMKSARNSCWSKDAEYGLYSIYQGGIFELKENDRIFVSVTNEHLIDMDHE-ASFFGAF :. .... : . . :: :..: :.:.:...:.:.. :.:. .: .::::: NP_005 TQLLMGTKSVCEVGSNWF--QPIYLGAMFSLQEGDKLMVNVSDISLVDYTKEDKTFFGAF 200 210 220 230 240 280 pF1KE2 LVG :. NP_005 LL 250 281 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Mon Nov 7 00:03:16 2016 done: Mon Nov 7 00:03:17 2016 Total Scan time: 6.680 Total Display time: 0.010 Function used was FASTA [36.3.4 Apr, 2011]