FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE5519, 465 aa 1>>>pF1KE5519 465 - 465 aa - 465 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.8142+/-0.000471; mu= 20.6770+/- 0.029 mean_var=68.3344+/-13.904, 0's: 0 Z-trim(109.4): 166 B-trim: 253 in 1/51 Lambda= 0.155151 statistics sampled from 17415 (17595) to 17415 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.545), E-opt: 0.2 (0.206), width: 16 Scan time: 6.410 The best scores are: opt bits E(85289) NP_775807 (OMIM: 137166) gamma-aminobutyric acid r ( 465) 3145 713.5 2.9e-205 NP_000807 (OMIM: 137164,607681,611277) gamma-amino ( 467) 2362 538.3 1.7e-152 NP_944494 (OMIM: 137164,607681,611277) gamma-amino ( 475) 2343 534.0 3.3e-151 XP_016863479 (OMIM: 137166) PREDICTED: gamma-amino ( 336) 2288 521.6 1.3e-147 XP_011519732 (OMIM: 600233) PREDICTED: gamma-amino ( 473) 1744 400.0 7.5e-111 NP_150092 (OMIM: 600233) gamma-aminobutyric acid r ( 467) 1741 399.3 1.2e-110 XP_016877547 (OMIM: 600233) PREDICTED: gamma-amino ( 361) 1323 305.6 1.4e-82 XP_016877548 (OMIM: 600233) PREDICTED: gamma-amino ( 355) 1320 304.9 2.2e-82 XP_005268315 (OMIM: 137142) PREDICTED: gamma-amino ( 462) 1258 291.2 4.1e-78 NP_001158509 (OMIM: 137142) gamma-aminobutyric aci ( 462) 1258 291.2 4.1e-78 XP_006720522 (OMIM: 137142) PREDICTED: gamma-amino ( 462) 1258 291.2 4.1e-78 NP_000801 (OMIM: 137142) gamma-aminobutyric acid r ( 462) 1258 291.2 4.1e-78 NP_001121117 (OMIM: 137160,611136,615744) gamma-am ( 456) 1232 285.3 2.3e-76 NP_001121120 (OMIM: 137160,611136,615744) gamma-am ( 456) 1232 285.3 2.3e-76 NP_001121116 (OMIM: 137160,611136,615744) gamma-am ( 456) 1232 285.3 2.3e-76 NP_001121115 (OMIM: 137160,611136,615744) gamma-am ( 456) 1232 285.3 2.3e-76 NP_000797 (OMIM: 137160,611136,615744) gamma-amino ( 456) 1232 285.3 2.3e-76 NP_004952 (OMIM: 300093) gamma-aminobutyric acid r ( 506) 1229 284.7 3.9e-76 XP_016863472 (OMIM: 103780,137140) PREDICTED: gamm ( 451) 1225 283.8 6.7e-76 NP_000798 (OMIM: 103780,137140) gamma-aminobutyric ( 451) 1225 283.8 6.7e-76 NP_001107647 (OMIM: 103780,137140) gamma-aminobuty ( 451) 1225 283.8 6.7e-76 XP_016863471 (OMIM: 103780,137140) PREDICTED: gamm ( 451) 1225 283.8 6.7e-76 NP_001191195 (OMIM: 137141) gamma-aminobutyric aci ( 535) 1225 283.8 7.7e-76 NP_000800 (OMIM: 137141) gamma-aminobutyric acid r ( 554) 1225 283.8 7.9e-76 NP_000802 (OMIM: 137143) gamma-aminobutyric acid r ( 453) 1219 282.4 1.7e-75 NP_000799 (OMIM: 305660) gamma-aminobutyric acid r ( 492) 1182 274.2 5.7e-73 NP_001317619 (OMIM: 103780,137140) gamma-aminobuty ( 511) 1145 265.9 1.8e-70 XP_011511977 (OMIM: 103780,137140) PREDICTED: gamm ( 511) 1145 265.9 1.8e-70 NP_001257802 (OMIM: 600233) gamma-aminobutyric aci ( 253) 1118 259.6 7.1e-69 XP_005248137 (OMIM: 103780,137140) PREDICTED: gamm ( 396) 1091 253.7 6.5e-67 XP_016884878 (OMIM: 300093) PREDICTED: gamma-amino ( 267) 1077 250.5 4.3e-66 XP_016884875 (OMIM: 300093) PREDICTED: gamma-amino ( 393) 1076 250.4 6.7e-66 NP_944493 (OMIM: 137164,607681,611277) gamma-amino ( 515) 1017 237.3 7.7e-62 NP_001273756 (OMIM: 103780,137140) gamma-aminobuty ( 456) 1011 235.9 1.8e-61 XP_006724874 (OMIM: 305660) PREDICTED: gamma-amino ( 340) 922 215.8 1.4e-55 NP_001139512 (OMIM: 138491,149400) glycine recepto ( 457) 922 216.0 1.8e-55 XP_016877545 (OMIM: 137142) PREDICTED: gamma-amino ( 306) 919 215.1 2.1e-55 XP_016877544 (OMIM: 137142) PREDICTED: gamma-amino ( 306) 919 215.1 2.1e-55 NP_006520 (OMIM: 600421) glycine receptor subunit ( 464) 917 214.8 3.9e-55 XP_016864119 (OMIM: 600421) PREDICTED: glycine rec ( 424) 914 214.1 5.8e-55 NP_000162 (OMIM: 138491,149400) glycine receptor s ( 449) 909 213.0 1.3e-54 XP_016864838 (OMIM: 138491,149400) PREDICTED: glyc ( 465) 909 213.1 1.4e-54 NP_001243632 (OMIM: 137161) gamma-aminobutyric aci ( 462) 904 211.9 2.9e-54 NP_002033 (OMIM: 137161) gamma-aminobutyric acid r ( 479) 904 211.9 3e-54 NP_000804 (OMIM: 600232) gamma-aminobutyric acid r ( 474) 896 210.1 1e-53 NP_068711 (OMIM: 600232) gamma-aminobutyric acid r ( 512) 896 210.2 1.1e-53 NP_001112357 (OMIM: 305990) glycine receptor subun ( 452) 894 209.7 1.4e-53 NP_002054 (OMIM: 305990) glycine receptor subunit ( 452) 894 209.7 1.4e-53 XP_016884916 (OMIM: 305990) PREDICTED: glycine rec ( 452) 892 209.2 1.8e-53 NP_001112358 (OMIM: 305990) glycine receptor subun ( 452) 892 209.2 1.8e-53 >>NP_775807 (OMIM: 137166) gamma-aminobutyric acid recep (465 aa) initn: 3145 init1: 3145 opt: 3145 Z-score: 3806.1 bits: 713.5 E(85289): 2.9e-205 Smith-Waterman score: 3145; 99.8% identity (99.8% similar) in 465 aa overlap (1-465:1-465) 10 20 30 40 50 60 pF1KE5 MGPLKAFLFSPFLLRSQSRGVRLVFLLLTLHLGNCVDKADDEDDEDLTVNKTWVLAPKIH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_775 MGPLKAFLFSPFLLRSQSRGVRLVFLLLTLHLGNCVDKADDEDDEDLTVNKTWVLAPKIH 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE5 EGDITQILNSLLQGYDNKLRPDIGVRPTVIETDVYVNSIGPVDPINMEYTIDIIFAQTWF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_775 EGDITQILNSLLQGYDNKLRPDIGVRPTVIETDVYVNSIGPVDPINMEYTIDIIFAQTWF 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE5 DSRLKFNSTMKVLMLNSNMVGKIWIPDTFFRNSRKSDAHWITTPNRLLRIWNDGRVLYTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_775 DSRLKFNSTMKVLMLNSNMVGKIWIPDTFFRNSRKSDAHWITTPNRLLRIWNDGRVLYTL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE5 RLTINAECYLQLHNFPMDEHSCPLEFSSYGYPKNEIEYKWKKPSVEVADPKYWRLYQFAF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_775 RLTINAECYLQLHNFPMDEHSCPLEFSSYGYPKNEIEYKWKKPSVEVADPKYWRLYQFAF 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE5 VGLRNSTEITHTISGDYVIMTIFFDLSRRMGYFTIQTYIPCILTVVLSWVSFWINKDAVP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_775 VGLRNSTEITHTISGDYVIMTIFFDLSRRMGYFTIQTYIPCILTVVLSWVSFWINKDAVP 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE5 ARTSLGITTVLTMTTLSTIARKSLPKVSYVTAMDLFVSVCFIFVFAALMEYGTLHYFTSN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_775 ARTSLGITTVLTMTTLSTIARKSLPKVSYVTAMDLFVSVCFIFVFAALMEYGTLHYFTSN 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE5 QKGKTATKDRKLKNKASMTPGLHPGSTLIPMNNISVPQEDDYEYQCLEGKDCASFFCCFE :::::::::::::::::::::::::::::::::::::::::: ::::::::::::::::: NP_775 QKGKTATKDRKLKNKASMTPGLHPGSTLIPMNNISVPQEDDYGYQCLEGKDCASFFCCFE 370 380 390 400 410 420 430 440 450 460 pF1KE5 DCRTGSWREGRIHIRIAKIDSYSRIFFPTAFALFNLVYWVGYLYL ::::::::::::::::::::::::::::::::::::::::::::: NP_775 DCRTGSWREGRIHIRIAKIDSYSRIFFPTAFALFNLVYWVGYLYL 430 440 450 460 >>NP_000807 (OMIM: 137164,607681,611277) gamma-aminobuty (467 aa) initn: 2271 init1: 2271 opt: 2362 Z-score: 2858.8 bits: 538.3 E(85289): 1.7e-152 Smith-Waterman score: 2362; 77.9% identity (90.5% similar) in 444 aa overlap (24-465:27-467) 10 20 30 40 50 pF1KE5 MGPLKAFLFSPFLLRSQSRGVRLVFLLLTLHLGNCVDKADDEDDEDLTVNKTWVLAP ..:::.:. : .:.:: : :: . ::::::.: NP_000 MSSPNIWSTGSSVYSTPVFSQKMTVWILLLLSLYPGFTSQKSDD-DYEDYASNKTWVLTP 10 20 30 40 50 60 70 80 90 100 110 pF1KE5 KIHEGDITQILNSLLQGYDNKLRPDIGVRPTVIETDVYVNSIGPVDPINMEYTIDIIFAQ :. :::.: :::.::.::::::::::::.::.:.::.::::::::. :::::::::.::: NP_000 KVPEGDVTVILNNLLEGYDNKLRPDIGVKPTLIHTDMYVNSIGPVNAINMEYTIDIFFAQ 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE5 TWFDSRLKFNSTMKVLMLNSNMVGKIWIPDTFFRNSRKSDAHWITTPNRLLRIWNDGRVL ::.: :::::::.::: :::::::::::::::::::.:.::::::::::.:::::::::: NP_000 TWYDRRLKFNSTIKVLRLNSNMVGKIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVL 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE5 YTLRLTINAECYLQLHNFPMDEHSCPLEFSSYGYPKNEIEYKWKKPSVEVADPKYWRLYQ :::::::.::: :::::::::::::::::::::::..:: :.::. ::::.: . ::::: NP_000 YTLRLTIDAECQLQLHNFPMDEHSCPLEFSSYGYPREEIVYQWKRSSVEVGDTRSWRLYQ 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE5 FAFVGLRNSTEITHTISGDYVIMTIFFDLSRRMGYFTIQTYIPCILTVVLSWVSFWINKD :.::::::.::...: :::::.:...:::::::::::::::::: : ::::::::::::: NP_000 FSFVGLRNTTEVVKTTSGDYVVMSVYFDLSRRMGYFTIQTYIPCTLIVVLSWVSFWINKD 240 250 260 270 280 290 300 310 320 330 340 350 pF1KE5 AVPARTSLGITTVLTMTTLSTIARKSLPKVSYVTAMDLFVSVCFIFVFAALMEYGTLHYF ::::::::::::::::::::::::::::::::::::::::::::::::.::.:::::::: NP_000 AVPARTSLGITTVLTMTTLSTIARKSLPKVSYVTAMDLFVSVCFIFVFSALVEYGTLHYF 300 310 320 330 340 350 360 370 380 390 400 410 pF1KE5 TSNQKGKTATKDRKLKNKASMTPGLHPGSTLIPMNNISVPQEDD--YEYQCLEGKDCASF .::.: . ::.: :: : : ..: :. : ::: . :: : : :.::.::::::: NP_000 VSNRK-PSKDKDKKKKNPAP-TIDIRPRSATIQMNNATHLQERDEEYGYECLDGKDCASF 360 370 380 390 400 410 420 430 440 450 460 pF1KE5 FCCFEDCRTGSWREGRIHIRIAKIDSYSRIFFPTAFALFNLVYWVGYLYL ::::::::::.::.:::::::::.:::.:::::::: ::::::::.:::: NP_000 FCCFEDCRTGAWRHGRIHIRIAKMDSYARIFFPTAFCLFNLVYWVSYLYL 420 430 440 450 460 >>NP_944494 (OMIM: 137164,607681,611277) gamma-aminobuty (475 aa) initn: 2284 init1: 1870 opt: 2343 Z-score: 2835.7 bits: 534.0 E(85289): 3.3e-151 Smith-Waterman score: 2343; 76.8% identity (89.2% similar) in 452 aa overlap (24-465:27-475) 10 20 30 40 50 pF1KE5 MGPLKAFLFSPFLLRSQSRGVRLVFLLLTLHLGNCVDKADDEDDEDLTVNKTWVLAP ..:::.:. : .:.:: : :: . ::::::.: NP_944 MSSPNIWSTGSSVYSTPVFSQKMTVWILLLLSLYPGFTSQKSDD-DYEDYASNKTWVLTP 10 20 30 40 50 60 70 80 90 100 110 pF1KE5 KIHEGDITQILNSLLQGYDNKLRPDIGVRPTVIETDVYVNSIGPVDPINMEYTIDIIFAQ :. :::.: :::.::.::::::::::::.::.:.::.::::::::. :::::::::.::: NP_944 KVPEGDVTVILNNLLEGYDNKLRPDIGVKPTLIHTDMYVNSIGPVNAINMEYTIDIFFAQ 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE5 TWFDSRLKFNSTMKVLMLNSNMVGKIWIPDTFFRNSRKSDAHWITTPNRLLRIWNDGRVL ::.: :::::::.::: :::::::::::::::::::.:.::::::::::.:::::::::: NP_944 TWYDRRLKFNSTIKVLRLNSNMVGKIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVL 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE5 YTLRLTINAECYLQLHNFPMDEHSCPLEFSSYGYPKNEIEYKWKKPSVEVADPKYWRLYQ :::::::.::: :::::::::::::::::::::::..:: :.::. ::::.: . ::::: NP_944 YTLRLTIDAECQLQLHNFPMDEHSCPLEFSSYGYPREEIVYQWKRSSVEVGDTRSWRLYQ 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE5 FAFVGLRNSTEITHTISGDYVIMTIFFDLSRRMGYFTIQTYIPCILTVVLSWVSFWINKD :.::::::.::...: :::::.:...:::::::::::::::::: : ::::::::::::: NP_944 FSFVGLRNTTEVVKTTSGDYVVMSVYFDLSRRMGYFTIQTYIPCTLIVVLSWVSFWINKD 240 250 260 270 280 290 300 310 320 330 340 350 pF1KE5 AVPARTSLGITTVLTMTTLSTIARKSLPKVSYVTAMDLFVSVCFIFVFAALMEYGTLHYF ::::::::::::::::::::::::::::::::::::::::::::::::.::.:::::::: NP_944 AVPARTSLGITTVLTMTTLSTIARKSLPKVSYVTAMDLFVSVCFIFVFSALVEYGTLHYF 300 310 320 330 340 350 360 370 380 390 400 pF1KE5 TSNQKGKTATKDRKLKN--------KASMTPGLHPGSTLIPMNNISVPQEDD--YEYQCL .::.: . ::.: :: :: : ..: :. : ::: . :: : : :.:: NP_944 VSNRK-PSKDKDKKKKNPLLRMFSFKAP-TIDIRPRSATIQMNNATHLQERDEEYGYECL 360 370 380 390 400 410 410 420 430 440 450 460 pF1KE5 EGKDCASFFCCFEDCRTGSWREGRIHIRIAKIDSYSRIFFPTAFALFNLVYWVGYLYL .:::::::::::::::::.::.:::::::::.:::.:::::::: ::::::::.:::: NP_944 DGKDCASFFCCFEDCRTGAWRHGRIHIRIAKMDSYARIFFPTAFCLFNLVYWVSYLYL 420 430 440 450 460 470 >>XP_016863479 (OMIM: 137166) PREDICTED: gamma-aminobuty (336 aa) initn: 2288 init1: 2288 opt: 2288 Z-score: 2771.2 bits: 521.6 E(85289): 1.3e-147 Smith-Waterman score: 2288; 99.7% identity (99.7% similar) in 336 aa overlap (130-465:1-336) 100 110 120 130 140 150 pF1KE5 GPVDPINMEYTIDIIFAQTWFDSRLKFNSTMKVLMLNSNMVGKIWIPDTFFRNSRKSDAH :::::::::::::::::::::::::::::: XP_016 MKVLMLNSNMVGKIWIPDTFFRNSRKSDAH 10 20 30 160 170 180 190 200 210 pF1KE5 WITTPNRLLRIWNDGRVLYTLRLTINAECYLQLHNFPMDEHSCPLEFSSYGYPKNEIEYK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 WITTPNRLLRIWNDGRVLYTLRLTINAECYLQLHNFPMDEHSCPLEFSSYGYPKNEIEYK 40 50 60 70 80 90 220 230 240 250 260 270 pF1KE5 WKKPSVEVADPKYWRLYQFAFVGLRNSTEITHTISGDYVIMTIFFDLSRRMGYFTIQTYI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 WKKPSVEVADPKYWRLYQFAFVGLRNSTEITHTISGDYVIMTIFFDLSRRMGYFTIQTYI 100 110 120 130 140 150 280 290 300 310 320 330 pF1KE5 PCILTVVLSWVSFWINKDAVPARTSLGITTVLTMTTLSTIARKSLPKVSYVTAMDLFVSV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PCILTVVLSWVSFWINKDAVPARTSLGITTVLTMTTLSTIARKSLPKVSYVTAMDLFVSV 160 170 180 190 200 210 340 350 360 370 380 390 pF1KE5 CFIFVFAALMEYGTLHYFTSNQKGKTATKDRKLKNKASMTPGLHPGSTLIPMNNISVPQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CFIFVFAALMEYGTLHYFTSNQKGKTATKDRKLKNKASMTPGLHPGSTLIPMNNISVPQE 220 230 240 250 260 270 400 410 420 430 440 450 pF1KE5 DDYEYQCLEGKDCASFFCCFEDCRTGSWREGRIHIRIAKIDSYSRIFFPTAFALFNLVYW ::: :::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DDYGYQCLEGKDCASFFCCFEDCRTGSWREGRIHIRIAKIDSYSRIFFPTAFALFNLVYW 280 290 300 310 320 330 460 pF1KE5 VGYLYL :::::: XP_016 VGYLYL >>XP_011519732 (OMIM: 600233) PREDICTED: gamma-aminobuty (473 aa) initn: 2103 init1: 1727 opt: 1744 Z-score: 2111.2 bits: 400.0 E(85289): 7.5e-111 Smith-Waterman score: 2095; 67.0% identity (83.8% similar) in 469 aa overlap (24-465:5-473) 10 20 30 40 50 pF1KE5 MGPLKAFLFSPFLLRSQSRGVRLVFLLLTLHLG-NCVDKADDEDD-EDLTVNKTWVLAPK ..::: : : . .. .::. :: . :. :::::: XP_011 MAPKLLLLLCLFSGLHARSRKVEEDEYEDSSSNQKWVLAPK 10 20 30 40 60 70 80 90 100 110 pF1KE5 IHEGDITQILNSLLQGYDNKLRPDIGVRPTVIETDVYVNSIGPVDPINMEYTIDIIFAQT .. :.: :::.::. ::.:::::::..::::..:.::::::::. ::::: :::.:::: XP_011 SQDTDVTLILNKLLREYDKKLRPDIGIKPTVIDVDIYVNSIGPVSSINMEYQIDIFFAQT 50 60 70 80 90 100 120 130 140 150 160 170 pF1KE5 WFDSRLKFNSTMKVLMLNSNMVGKIWIPDTFFRNSRKSDAHWITTPNRLLRIWNDGRVLY : ::::.::::::.: ::::::: ::::::.::::. ..::::::::.::::::::..:: XP_011 WTDSRLRFNSTMKILTLNSNMVGLIWIPDTIFRNSKTAEAHWITTPNQLLRIWNDGKILY 110 120 130 140 150 160 180 190 200 210 220 230 pF1KE5 TLRLTINAECYLQLHNFPMDEHSCPLEFSSYGYPKNEIEYKWKKPSVEVADPKYWRLYQF :::::::::: ::::::::::::::: ::::::::.:. :.:.: :::.:: : :::::: XP_011 TLRLTINAECQLQLHNFPMDEHSCPLIFSSYGYPKEEMIYRWRKNSVEAADQKSWRLYQF 170 180 190 200 210 220 240 250 260 270 280 290 pF1KE5 AFVGLRNSTEITHTISGDYVIMTIFFDLSRRMGYFTIQTYIPCILTVVLSWVSFWINKDA :.::::.:::. : .::::.:::.:.:::::::::::::::::::::::::::::.::: XP_011 DFMGLRNTTEIVTTSAGDYVVMTIYFELSRRMGYFTIQTYIPCILTVVLSWVSFWIKKDA 230 240 250 260 270 280 300 310 320 330 340 350 pF1KE5 VPARTSLGITTVLTMTTLSTIARKSLPKVSYVTAMDLFVSVCFIFVFAALMEYGTLHYFT .::::.:::::::::::::::::::::.:::::::::::.:::.:::::::::.::.:.. XP_011 TPARTALGITTVLTMTTLSTIARKSLPRVSYVTAMDLFVTVCFLFVFAALMEYATLNYYS 290 300 310 320 330 340 360 370 380 390 pF1KE5 SNQKGKTATK---------DRKLKNKASM-TPGLH-------------PGSTLIPMNNIS : .: :. : .: . .. :. .:... : ...: .:: XP_011 SCRKPTTTKKTTSLLHPDSSRWIPERISLQAPSVRIALQNYSLLDMRPPPTAMITLNNSV 350 360 370 380 390 400 400 410 420 430 440 450 pF1KE5 VPQE--DDYEYQCLEGKDCASFFCCFEDCRTGSWREGRIHIRIAKIDSYSRIFFPTAFAL :: : :.::.:::: :::::.:.:..::::.::::: : ..:::::.::::.: : XP_011 YWQEFEDTCVYECLDGKDCQSFFCCYEECKSGSWRKGRIHIDILELDSYSRVFFPTSFLL 410 420 430 440 450 460 460 pF1KE5 FNLVYWVGYLYL :::::::::::: XP_011 FNLVYWVGYLYL 470 >>NP_150092 (OMIM: 600233) gamma-aminobutyric acid recep (467 aa) initn: 2103 init1: 1727 opt: 1741 Z-score: 2107.6 bits: 399.3 E(85289): 1.2e-110 Smith-Waterman score: 2104; 67.8% identity (84.7% similar) in 463 aa overlap (24-465:5-467) 10 20 30 40 50 pF1KE5 MGPLKAFLFSPFLLRSQSRGVRLVFLLLTLHLG-NCVDKADDEDD-EDLTVNKTWVLAPK ..::: : : . .. .::. :: . :. :::::: NP_150 MAPKLLLLLCLFSGLHARSRKVEEDEYEDSSSNQKWVLAPK 10 20 30 40 60 70 80 90 100 110 pF1KE5 IHEGDITQILNSLLQGYDNKLRPDIGVRPTVIETDVYVNSIGPVDPINMEYTIDIIFAQT .. :.: :::.::. ::.:::::::..::::..:.::::::::. ::::: :::.:::: NP_150 SQDTDVTLILNKLLREYDKKLRPDIGIKPTVIDVDIYVNSIGPVSSINMEYQIDIFFAQT 50 60 70 80 90 100 120 130 140 150 160 170 pF1KE5 WFDSRLKFNSTMKVLMLNSNMVGKIWIPDTFFRNSRKSDAHWITTPNRLLRIWNDGRVLY : ::::.::::::.: ::::::: ::::::.::::. ..::::::::.::::::::..:: NP_150 WTDSRLRFNSTMKILTLNSNMVGLIWIPDTIFRNSKTAEAHWITTPNQLLRIWNDGKILY 110 120 130 140 150 160 180 190 200 210 220 230 pF1KE5 TLRLTINAECYLQLHNFPMDEHSCPLEFSSYGYPKNEIEYKWKKPSVEVADPKYWRLYQF :::::::::: ::::::::::::::: ::::::::.:. :.:.: :::.:: : :::::: NP_150 TLRLTINAECQLQLHNFPMDEHSCPLIFSSYGYPKEEMIYRWRKNSVEAADQKSWRLYQF 170 180 190 200 210 220 240 250 260 270 280 290 pF1KE5 AFVGLRNSTEITHTISGDYVIMTIFFDLSRRMGYFTIQTYIPCILTVVLSWVSFWINKDA :.::::.:::. : .::::.:::.:.:::::::::::::::::::::::::::::.::: NP_150 DFMGLRNTTEIVTTSAGDYVVMTIYFELSRRMGYFTIQTYIPCILTVVLSWVSFWIKKDA 230 240 250 260 270 280 300 310 320 330 340 350 pF1KE5 VPARTSLGITTVLTMTTLSTIARKSLPKVSYVTAMDLFVSVCFIFVFAALMEYGTLHYFT .::::.:::::::::::::::::::::.:::::::::::.:::.:::::::::.::.:.. NP_150 TPARTALGITTVLTMTTLSTIARKSLPRVSYVTAMDLFVTVCFLFVFAALMEYATLNYYS 290 300 310 320 330 340 360 370 380 390 pF1KE5 SNQKGKTATK---------DRKLKNKASM-TPGLH-------PGSTLIPMNNISVPQE-- : .: :. : .: . .. :. .:. . : ...: .:: :: NP_150 SCRKPTTTKKTTSLLHPDSSRWIPERISLQAPSNYSLLDMRPPPTAMITLNNSVYWQEFE 350 360 370 380 390 400 400 410 420 430 440 450 pF1KE5 DDYEYQCLEGKDCASFFCCFEDCRTGSWREGRIHIRIAKIDSYSRIFFPTAFALFNLVYW : :.::.:::: :::::.:.:..::::.::::: : ..:::::.::::.: ::::::: NP_150 DTCVYECLDGKDCQSFFCCYEECKSGSWRKGRIHIDILELDSYSRVFFPTSFLLFNLVYW 410 420 430 440 450 460 460 pF1KE5 VGYLYL :::::: NP_150 VGYLYL >>XP_016877547 (OMIM: 600233) PREDICTED: gamma-aminobuty (361 aa) initn: 1696 init1: 1320 opt: 1323 Z-score: 1603.4 bits: 305.6 E(85289): 1.4e-82 Smith-Waterman score: 1674; 68.7% identity (84.2% similar) in 361 aa overlap (130-465:1-361) 100 110 120 130 140 150 pF1KE5 GPVDPINMEYTIDIIFAQTWFDSRLKFNSTMKVLMLNSNMVGKIWIPDTFFRNSRKSDAH ::.: ::::::: ::::::.::::. ..:: XP_016 MKILTLNSNMVGLIWIPDTIFRNSKTAEAH 10 20 30 160 170 180 190 200 210 pF1KE5 WITTPNRLLRIWNDGRVLYTLRLTINAECYLQLHNFPMDEHSCPLEFSSYGYPKNEIEYK ::::::.::::::::..:::::::::::: ::::::::::::::: ::::::::.:. :. XP_016 WITTPNQLLRIWNDGKILYTLRLTINAECQLQLHNFPMDEHSCPLIFSSYGYPKEEMIYR 40 50 60 70 80 90 220 230 240 250 260 270 pF1KE5 WKKPSVEVADPKYWRLYQFAFVGLRNSTEITHTISGDYVIMTIFFDLSRRMGYFTIQTYI :.: :::.:: : :::::: :.::::.:::. : .::::.:::.:.:::::::::::::: XP_016 WRKNSVEAADQKSWRLYQFDFMGLRNTTEIVTTSAGDYVVMTIYFELSRRMGYFTIQTYI 100 110 120 130 140 150 280 290 300 310 320 330 pF1KE5 PCILTVVLSWVSFWINKDAVPARTSLGITTVLTMTTLSTIARKSLPKVSYVTAMDLFVSV :::::::::::::::.:::.::::.:::::::::::::::::::::.:::::::::::.: XP_016 PCILTVVLSWVSFWIKKDATPARTALGITTVLTMTTLSTIARKSLPRVSYVTAMDLFVTV 160 170 180 190 200 210 340 350 360 370 380 pF1KE5 CFIFVFAALMEYGTLHYFTSNQKGKTATK---------DRKLKNKASM-TPGLH------ ::.:::::::::.::.:..: .: :. : .: . .. :. .:... XP_016 CFLFVFAALMEYATLNYYSSCRKPTTTKKTTSLLHPDSSRWIPERISLQAPSVRIALQNY 220 230 240 250 260 270 390 400 410 420 430 pF1KE5 -------PGSTLIPMNNISVPQE--DDYEYQCLEGKDCASFFCCFEDCRTGSWREGRIHI : ...: .:: :: : :.::.:::: :::::.:.:..::::.::::: XP_016 SLLDMRPPPTAMITLNNSVYWQEFEDTCVYECLDGKDCQSFFCCYEECKSGSWRKGRIHI 280 290 300 310 320 330 440 450 460 pF1KE5 RIAKIDSYSRIFFPTAFALFNLVYWVGYLYL : ..:::::.::::.: ::::::::::::: XP_016 DILELDSYSRVFFPTSFLLFNLVYWVGYLYL 340 350 360 >>XP_016877548 (OMIM: 600233) PREDICTED: gamma-aminobuty (355 aa) initn: 1696 init1: 1320 opt: 1320 Z-score: 1599.9 bits: 304.9 E(85289): 2.2e-82 Smith-Waterman score: 1683; 69.9% identity (85.4% similar) in 355 aa overlap (130-465:1-355) 100 110 120 130 140 150 pF1KE5 GPVDPINMEYTIDIIFAQTWFDSRLKFNSTMKVLMLNSNMVGKIWIPDTFFRNSRKSDAH ::.: ::::::: ::::::.::::. ..:: XP_016 MKILTLNSNMVGLIWIPDTIFRNSKTAEAH 10 20 30 160 170 180 190 200 210 pF1KE5 WITTPNRLLRIWNDGRVLYTLRLTINAECYLQLHNFPMDEHSCPLEFSSYGYPKNEIEYK ::::::.::::::::..:::::::::::: ::::::::::::::: ::::::::.:. :. XP_016 WITTPNQLLRIWNDGKILYTLRLTINAECQLQLHNFPMDEHSCPLIFSSYGYPKEEMIYR 40 50 60 70 80 90 220 230 240 250 260 270 pF1KE5 WKKPSVEVADPKYWRLYQFAFVGLRNSTEITHTISGDYVIMTIFFDLSRRMGYFTIQTYI :.: :::.:: : :::::: :.::::.:::. : .::::.:::.:.:::::::::::::: XP_016 WRKNSVEAADQKSWRLYQFDFMGLRNTTEIVTTSAGDYVVMTIYFELSRRMGYFTIQTYI 100 110 120 130 140 150 280 290 300 310 320 330 pF1KE5 PCILTVVLSWVSFWINKDAVPARTSLGITTVLTMTTLSTIARKSLPKVSYVTAMDLFVSV :::::::::::::::.:::.::::.:::::::::::::::::::::.:::::::::::.: XP_016 PCILTVVLSWVSFWIKKDATPARTALGITTVLTMTTLSTIARKSLPRVSYVTAMDLFVTV 160 170 180 190 200 210 340 350 360 370 380 pF1KE5 CFIFVFAALMEYGTLHYFTSNQKGKTATK---------DRKLKNKASM-TPGLH------ ::.:::::::::.::.:..: .: :. : .: . .. :. .:. . XP_016 CFLFVFAALMEYATLNYYSSCRKPTTTKKTTSLLHPDSSRWIPERISLQAPSNYSLLDMR 220 230 240 250 260 270 390 400 410 420 430 440 pF1KE5 -PGSTLIPMNNISVPQE--DDYEYQCLEGKDCASFFCCFEDCRTGSWREGRIHIRIAKID : ...: .:: :: : :.::.:::: :::::.:.:..::::.::::: : ..: XP_016 PPPTAMITLNNSVYWQEFEDTCVYECLDGKDCQSFFCCYEECKSGSWRKGRIHIDILELD 280 290 300 310 320 330 450 460 pF1KE5 SYSRIFFPTAFALFNLVYWVGYLYL ::::.::::.: ::::::::::::: XP_016 SYSRVFFPTSFLLFNLVYWVGYLYL 340 350 >>XP_005268315 (OMIM: 137142) PREDICTED: gamma-aminobuty (462 aa) initn: 1260 init1: 650 opt: 1258 Z-score: 1523.4 bits: 291.2 E(85289): 4.1e-78 Smith-Waterman score: 1258; 49.1% identity (75.6% similar) in 405 aa overlap (65-463:50-449) 40 50 60 70 80 90 pF1KE5 CVDKADDEDDEDLTVNKTWVLAPKIHEGDITQILNSLLQGYDNKLRPDIGVRPTVIETDV :.::..::.::::.::: .: : : ..::. XP_005 ISMNLSSHFGFSQMPTSSVKDETNDNITIFTRILDGLLDGYDNRLRPGLGERITQVRTDI 20 30 40 50 60 70 100 110 120 130 140 150 pF1KE5 YVNSIGPVDPINMEYTIDIIFAQTWFDSRLKFNSTMKVLMLNSNMVGKIWIPDTFFRNSR ::.:.:::. .::::::..: :.: : ::.:.. :. : ::. ...::: :::::.:.. XP_005 YVTSFGPVSDTEMEYTIDVFFRQSWKDERLRFKGPMQRLPLNNLLASKIWTPDTFFHNGK 80 90 100 110 120 130 160 170 180 190 200 210 pF1KE5 KSDAHWITTPNRLLRIWNDGRVLYTLRLTINAECYLQLHNFPMDEHSCPLEFSSYGYPKN :: :: .::::.:::. .:: .:::.::::.::: .::..:::: :.:::.:.::.::.. XP_005 KSIAHNMTTPNKLLRLEDDGTLLYTMRLTISAECPMQLEDFPMDAHACPLKFGSYAYPNS 140 150 160 170 180 190 220 230 240 250 260 270 pF1KE5 EIEYKWKK---PSVEVADPKYWRLYQFAFVGLRNSTEITHTISGDYVIMTIFFDLSRRMG :. : : . :: ::. :: :. ..: .:: : .:.:.::: : :.:..: XP_005 EVVYVWTNGSTKSVVVAEDGS-RLNQYHLMGQTVGTENISTSTGEYTIMTAHFHLKRKIG 200 210 220 230 240 250 280 290 300 310 320 330 pF1KE5 YFTIQTYIPCILTVVLSWVSFWINKDAVPARTSLGITTVLTMTTLSTIARKSLPKVSYVT ::.::::.:::.::.:: ::::.:...::::: .:.:::::::::: ::.:::::.:.: XP_005 YFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYAT 260 270 280 290 300 310 340 350 360 370 380 pF1KE5 AMDLFVSVCFIFVFAALMEYGTLHYFTSN---QKGKTATKDRKLKNKASMTPGLHPGSTL ::: :..::. :::.::.:..:..:::. :: : . :.:.: . :. ... XP_005 AMDWFIAVCYAFVFSALIEFATVNYFTKRGWAWDGKKALEAAKIKKKREVI--LNKSTNA 320 330 340 350 360 370 390 400 410 420 430 440 pF1KE5 IPMNNISVPQEDDYEYQCLEGKDCASFFCCFEDCRTGSWREGRIHIRIAKIDSYSRIFFP . ...: : . : .. .: . .:. . . . :.:::..::: :: XP_005 FTTGKMSHPPNIPKEQTPAGTSNTTSVSVKPSEEKTSESK--KTYNSISKIDKMSRIVFP 380 390 400 410 420 430 450 460 pF1KE5 TAFALFNLVYWVGYLYL . :. ::::::. :: XP_005 VLFGTFNLVYWATYLNREPVIKGAASPK 440 450 460 >>NP_001158509 (OMIM: 137142) gamma-aminobutyric acid re (462 aa) initn: 1260 init1: 650 opt: 1258 Z-score: 1523.4 bits: 291.2 E(85289): 4.1e-78 Smith-Waterman score: 1258; 49.1% identity (75.6% similar) in 405 aa overlap (65-463:50-449) 40 50 60 70 80 90 pF1KE5 CVDKADDEDDEDLTVNKTWVLAPKIHEGDITQILNSLLQGYDNKLRPDIGVRPTVIETDV :.::..::.::::.::: .: : : ..::. NP_001 ISMNLSSHFGFSQMPTSSVKDETNDNITIFTRILDGLLDGYDNRLRPGLGERITQVRTDI 20 30 40 50 60 70 100 110 120 130 140 150 pF1KE5 YVNSIGPVDPINMEYTIDIIFAQTWFDSRLKFNSTMKVLMLNSNMVGKIWIPDTFFRNSR ::.:.:::. .::::::..: :.: : ::.:.. :. : ::. ...::: :::::.:.. NP_001 YVTSFGPVSDTEMEYTIDVFFRQSWKDERLRFKGPMQRLPLNNLLASKIWTPDTFFHNGK 80 90 100 110 120 130 160 170 180 190 200 210 pF1KE5 KSDAHWITTPNRLLRIWNDGRVLYTLRLTINAECYLQLHNFPMDEHSCPLEFSSYGYPKN :: :: .::::.:::. .:: .:::.::::.::: .::..:::: :.:::.:.::.::.. NP_001 KSIAHNMTTPNKLLRLEDDGTLLYTMRLTISAECPMQLEDFPMDAHACPLKFGSYAYPNS 140 150 160 170 180 190 220 230 240 250 260 270 pF1KE5 EIEYKWKK---PSVEVADPKYWRLYQFAFVGLRNSTEITHTISGDYVIMTIFFDLSRRMG :. : : . :: ::. :: :. ..: .:: : .:.:.::: : :.:..: NP_001 EVVYVWTNGSTKSVVVAEDGS-RLNQYHLMGQTVGTENISTSTGEYTIMTAHFHLKRKIG 200 210 220 230 240 250 280 290 300 310 320 330 pF1KE5 YFTIQTYIPCILTVVLSWVSFWINKDAVPARTSLGITTVLTMTTLSTIARKSLPKVSYVT ::.::::.:::.::.:: ::::.:...::::: .:.:::::::::: ::.:::::.:.: NP_001 YFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYAT 260 270 280 290 300 310 340 350 360 370 380 pF1KE5 AMDLFVSVCFIFVFAALMEYGTLHYFTSN---QKGKTATKDRKLKNKASMTPGLHPGSTL ::: :..::. :::.::.:..:..:::. :: : . :.:.: . :. ... NP_001 AMDWFIAVCYAFVFSALIEFATVNYFTKRGWAWDGKKALEAAKIKKKREVI--LNKSTNA 320 330 340 350 360 370 390 400 410 420 430 440 pF1KE5 IPMNNISVPQEDDYEYQCLEGKDCASFFCCFEDCRTGSWREGRIHIRIAKIDSYSRIFFP . ...: : . : .. .: . .:. . . . :.:::..::: :: NP_001 FTTGKMSHPPNIPKEQTPAGTSNTTSVSVKPSEEKTSESK--KTYNSISKIDKMSRIVFP 380 390 400 410 420 430 450 460 pF1KE5 TAFALFNLVYWVGYLYL . :. ::::::. :: NP_001 VLFGTFNLVYWATYLNREPVIKGAASPK 440 450 460 465 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Nov 8 01:25:42 2016 done: Tue Nov 8 01:25:43 2016 Total Scan time: 6.410 Total Display time: 0.060 Function used was FASTA [36.3.4 Apr, 2011]