FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE1372, 578 aa 1>>>pF1KE1372 578 - 578 aa - 578 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 7.3349+/-0.00037; mu= 9.9207+/- 0.023 mean_var=144.2379+/-29.268, 0's: 0 Z-trim(118.0): 12 B-trim: 1573 in 1/54 Lambda= 0.106791 statistics sampled from 30566 (30578) to 30566 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.713), E-opt: 0.2 (0.359), width: 16 Scan time: 11.610 The best scores are: opt bits E(85289) NP_001549 (OMIM: 146933,613148) interleukin-10 rec ( 578) 3896 612.2 1.5e-174 NP_055247 (OMIM: 605620) interleukin-20 receptor s ( 553) 250 50.5 1.8e-05 XP_016866443 (OMIM: 605620) PREDICTED: interleukin ( 554) 236 48.3 7.9e-05 NP_851826 (OMIM: 606648) interleukin-22 receptor s ( 231) 222 45.9 0.00018 NP_851827 (OMIM: 606648) interleukin-22 receptor s ( 130) 188 40.4 0.0043 >>NP_001549 (OMIM: 146933,613148) interleukin-10 recepto (578 aa) initn: 3896 init1: 3896 opt: 3896 Z-score: 3254.9 bits: 612.2 E(85289): 1.5e-174 Smith-Waterman score: 3896; 99.8% identity (99.8% similar) in 578 aa overlap (1-578:1-578) 10 20 30 40 50 60 pF1KE1 MLPCLVVLLAALLSLRLGSDAHGTELPSPPSVWFEAEFFHHILHWTPIPNQSESTCYEVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MLPCLVVLLAALLSLRLGSDAHGTELPSPPSVWFEAEFFHHILHWTPIPNQSESTCYEVA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 LLRYGIESWNSISNCSQTLSYDLTAVTLDLYHSNGYRARVRAVDGSRHSNWTVTNTRFSV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LLRYGIESWNSISNCSQTLSYDLTAVTLDLYHSNGYRARVRAVDGSRHSNWTVTNTRFSV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 DEVTLTVGSVNLEIHNGFILGKIQLPRPKMAPANDTYESIFSHFREYEIAIRKVPGNFTF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DEVTLTVGSVNLEIHNGFILGKIQLPRPKMAPANDTYESIFSHFREYEIAIRKVPGNFTF 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 THKKVKHENFSLLTSGEVGEFCVQVKPSVASRSNKGMWSKEECISLTRQYFTVTNVIIFF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 THKKVKHENFSLLTSGEVGEFCVQVKPSVASRSNKGMWSKEECISLTRQYFTVTNVIIFF 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE1 AFVLLLSGALAYCLALQLYVRRRKKLPSVLLFKKPSPFIFISQRPSPETQDTIHPLDEEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AFVLLLSGALAYCLALQLYVRRRKKLPSVLLFKKPSPFIFISQRPSPETQDTIHPLDEEA 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE1 FLKVSPELKNLDLHGSTDSGFGSTKPSLQTEEPQFLLPDPHPQADRTLGNGEPPVLGDSC :::::::::::::::::::::::::::::::::::::::::::::::::: ::::::::: NP_001 FLKVSPELKNLDLHGSTDSGFGSTKPSLQTEEPQFLLPDPHPQADRTLGNREPPVLGDSC 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE1 SSGSSNSTDSGICLQEPSLSPSTGPTWEQQVGSNSRGQDDSGIDLVQNSEGRAGDTQGGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SSGSSNSTDSGICLQEPSLSPSTGPTWEQQVGSNSRGQDDSGIDLVQNSEGRAGDTQGGS 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE1 ALGHHSPPEPEVPGEEDPAAVAFQGYLRQTRCAEEKATKTGCLEEESPLTDGLGPKFGRC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ALGHHSPPEPEVPGEEDPAAVAFQGYLRQTRCAEEKATKTGCLEEESPLTDGLGPKFGRC 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE1 LVDEAGLHPPALAKGYLKQDPLEMTLASSGAPTGQWNQPTEEWSLLALSSCSDLGISDWS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LVDEAGLHPPALAKGYLKQDPLEMTLASSGAPTGQWNQPTEEWSLLALSSCSDLGISDWS 490 500 510 520 530 540 550 560 570 pF1KE1 FAHDLAPLGCVAAPGGLLGSFNSDLVTLPLISSLQSSE :::::::::::::::::::::::::::::::::::::: NP_001 FAHDLAPLGCVAAPGGLLGSFNSDLVTLPLISSLQSSE 550 560 570 >>NP_055247 (OMIM: 605620) interleukin-20 receptor subun (553 aa) initn: 124 init1: 65 opt: 250 Z-score: 219.3 bits: 50.5 E(85289): 1.8e-05 Smith-Waterman score: 256; 23.6% identity (53.8% similar) in 559 aa overlap (3-525:16-547) 10 20 30 40 pF1KE1 MLPCLVVLLAALLSLRLGSDAHGTELPSPPSVWFEAEFFHHILHWTP : :..:::: . . . : ::.: .. : . ....:.::: NP_055 MRAPGRPALRPLPLPPLLLLLLAAPWGRAVPCVSGG--LPKPANITFLSINMKNVLQWTP 10 20 30 40 50 50 60 70 80 90 100 pF1KE1 IPN--QSESTCYEVALLRYGIESWNSISNCSQ-TLSY-DLTAVTLDLYHSNGYRARVRAV :. :. .. : : . :: ..: . :.: . . .: ::.: : : :. : :.:.:. NP_055 -PEGLQGVKVTYTVQYFIYGQKKWLNKSECRNINRTYCDLSAETSDYEHQ--YYAKVKAI 60 70 80 90 100 110 110 120 130 140 150 160 pF1KE1 DGSRHSNWTVTNTRFSVDEVTLTVGSVNLEIHNGFILGKIQLPRP-KMAPAND--TYESI :.. :.:. .. . :. . : : . : . :. : : . ....: NP_055 WGTKCSKWAESGRFYPFLETQIGPPEVALTTDEKSISVVLTAPEKWKRNPEDLPVSMQQI 120 130 140 150 160 170 170 180 190 200 210 pF1KE1 FSHFREYEIAIRKVPGNFTFTHKKVKHENFSLLTSGEVGE-FCVQVKPSVASRSNKGMWS .:... :.... .. .: :... ..: .:: : . .::.:. : . ... : NP_055 YSNLK-YNVSVLNTKSNRTWSQCVTNHT--LVLTWLEPNTLYCVHVESFVPGPPRRAQPS 180 190 200 210 220 230 220 230 240 250 260 270 pF1KE1 KEECISLTRQYFTVTNVIIFFAFVLLLS------GALAYCLALQLYVRRRKKLPSVLLFK ...: .. . .. :.: .:: .: ....: . ..: ..:. :. :.. NP_055 EKQCARTLKDQSSEFKAKIIFWYVLPISITVFLFSVMGYSIYRYIHVGKEKH-PANLILI 240 250 260 270 280 290 280 290 300 310 320 pF1KE1 KPSPF---IFISQRPSPETQDTIHPLDEEAFLKVSPELKNLDLHGSTD-SGFGSTKPSLQ . : .:. :. . .. :. :.: . .: : :.: :.... .:: . NP_055 YGNEFDKRFFV---PAEKIVINFITLNISDDSKISHQDMSL-LGKSSDVSSLNDPQPSGN 300 310 320 330 340 330 340 350 360 370 380 pF1KE1 TEEPQFLLPDPHPQADRTLGNGEPPVLGDSCSSGSSNSTDSGICLQEPSLSPSTGPT--- . :: . . . :: . .. :.: :. ... :: ::: . : NP_055 LRPPQ------EEEEVKHLGYASH-LMEIFCDS-EENTEGTSLTQQE-SLSRTIPPDKTV 350 360 370 380 390 390 400 410 420 430 pF1KE1 --WEQQVGSNS--RGQDDSGIDLVQ--NSEGRAGDTQGGSA-LGHHSPPEPEVPGEEDPA .: .: ... : ... ..: . ...: ..:.. : :: .. .: .: NP_055 IEYEYDVRTTDICAGPEEQELSLQEEVSTQGTLLESQAALAVLGPQTLQYSYTPQLQDLD 400 410 420 430 440 450 440 450 460 470 480 490 pF1KE1 AVAFQGYLRQTRCAEEKATKTGCLEEESPLTDGLG-PKFGRCLVDEAGLHPPALAKGYLK .: : . . . ::. . : : . .: : : :... : : .: . . : : NP_055 PLA-QEHTDSEEGPEEEPSTT--LVDWDPQTGRLCIPSLSSFDQDSEGCEP-SEGDG-LG 460 470 480 490 500 510 500 510 520 530 540 550 pF1KE1 QDPLEMTLASSGAPT---GQWN----QPTEEWSLLALSSCSDLGISDWSFAHDLAPLGCV .. : : :: :. . : :::.: NP_055 EEGLLSRLYEEPAPDRPPGENETYLMQFMEEWGLYVQMEN 520 530 540 550 560 570 pF1KE1 AAPGGLLGSFNSDLVTLPLISSLQSSE >>XP_016866443 (OMIM: 605620) PREDICTED: interleukin-20 (554 aa) initn: 124 init1: 65 opt: 236 Z-score: 207.7 bits: 48.3 E(85289): 7.9e-05 Smith-Waterman score: 258; 23.8% identity (54.1% similar) in 560 aa overlap (3-525:16-548) 10 20 30 40 pF1KE1 MLPCLVVLLAALLSLRLGSDAHGTELPSPPSVWFEAEFFHHILHWTP : :..:::: . . . : ::.: .. : . ....:.::: XP_016 MRAPGRPALRPLPLPPLLLLLLAAPWGRAVPCVSGG--LPKPANITFLSINMKNVLQWTP 10 20 30 40 50 50 60 70 80 90 100 pF1KE1 IPN--QSESTCYEVA-LLRYGIESWNSISNCSQ-TLSY-DLTAVTLDLYHSNGYRARVRA :. :. .. : : ..::: ..: . :.: . . .: ::.: : : :. : :.:.: XP_016 -PEGLQGVKVTYTVQYFIRYGQKKWLNKSECRNINRTYCDLSAETSDYEHQ--YYAKVKA 60 70 80 90 100 110 110 120 130 140 150 pF1KE1 VDGSRHSNWTVTNTRFSVDEVTLTVGSVNLEIHNGFILGKIQLPRP-KMAPAND--TYES . :.. :.:. .. . :. . : : . : . :. : : . .... XP_016 IWGTKCSKWAESGRFYPFLETQIGPPEVALTTDEKSISVVLTAPEKWKRNPEDLPVSMQQ 120 130 140 150 160 170 160 170 180 190 200 210 pF1KE1 IFSHFREYEIAIRKVPGNFTFTHKKVKHENFSLLTSGEVGE-FCVQVKPSVASRSNKGMW :.:... :.... .. .: :... ..: .:: : . .::.:. : . ... XP_016 IYSNLK-YNVSVLNTKSNRTWSQCVTNHT--LVLTWLEPNTLYCVHVESFVPGPPRRAQP 180 190 200 210 220 230 220 230 240 250 260 270 pF1KE1 SKEECISLTRQYFTVTNVIIFFAFVL------LLSGALAYCLALQLYVRRRKKLPSVLLF :...: .. . .. :.: .:: .: ....: . ..: ..:. :. :.. XP_016 SEKQCARTLKDQSSEFKAKIIFWYVLPVSITVFLFSVMGYSIYRYIHVGKEKH-PANLIL 240 250 260 270 280 290 280 290 300 310 320 pF1KE1 KKPSPF---IFISQRPSPETQDTIHPLDEEAFLKVSPELKNLDLHGSTD-SGFGSTKPSL . : .:. :. . .. :. :.: . .: : :.: :.... .:: XP_016 IYGNEFDKRFFV---PAEKIVINFITLNISDDSKISHQDMSL-LGKSSDVSSLNDPQPSG 300 310 320 330 340 330 340 350 360 370 380 pF1KE1 QTEEPQFLLPDPHPQADRTLGNGEPPVLGDSCSSGSSNSTDSGICLQEPSLSPSTGPT-- . . :: . . . :: . .. :.: :. ... :: ::: . : XP_016 NLRPPQ------EEEEVKHLGYASH-LMEIFCDS-EENTEGTSLTQQE-SLSRTIPPDKT 350 360 370 380 390 390 400 410 420 430 pF1KE1 ---WEQQVGSNS--RGQDDSGIDLVQ--NSEGRAGDTQGGSA-LGHHSPPEPEVPGEEDP .: .: ... : ... ..: . ...: ..:.. : :: .. .: .: XP_016 VIEYEYDVRTTDICAGPEEQELSLQEEVSTQGTLLESQAALAVLGPQTLQYSYTPQLQDL 400 410 420 430 440 450 440 450 460 470 480 490 pF1KE1 AAVAFQGYLRQTRCAEEKATKTGCLEEESPLTDGLG-PKFGRCLVDEAGLHPPALAKGYL .: : . . . ::. . : : . .: : : :... : : .: . . : : XP_016 DPLA-QEHTDSEEGPEEEPSTT--LVDWDPQTGRLCIPSLSSFDQDSEGCEP-SEGDG-L 460 470 480 490 500 510 500 510 520 530 540 550 pF1KE1 KQDPLEMTLASSGAPT---GQWN----QPTEEWSLLALSSCSDLGISDWSFAHDLAPLGC .. : : :: :. . : :::.: XP_016 GEEGLLSRLYEEPAPDRPPGENETYLMQFMEEWGLYVQMEN 520 530 540 550 560 570 pF1KE1 VAAPGGLLGSFNSDLVTLPLISSLQSSE >>NP_851826 (OMIM: 606648) interleukin-22 receptor subun (231 aa) initn: 98 init1: 54 opt: 222 Z-score: 201.3 bits: 45.9 E(85289): 0.00018 Smith-Waterman score: 222; 26.2% identity (55.7% similar) in 244 aa overlap (1-226:1-230) 10 20 30 40 50 pF1KE1 MLP--CLVVLLAALLSLRLGSDAHGTELPSPPSVWFEAEFFHHILHWTPIPNQS-ESTCY :.: :.. .: ... ... : .: : :... ::.::.: : . .:. : NP_851 MMPKHCFLGFLISFFLTGVAGTQSTHESLKPQRVQFQSRNFHNILQWQPGRALTGNSSVY 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE1 EVALLRYGIESWNSISNC--SQTLSYDLTAVTLDLYHSNGYRARVRAVDGSRHSNWTVTN : :: ..:.. .: .: :: :::. : :. . : .::::.... .:.:..: NP_851 FVQYKIYGQRQWKNKEDCWGTQELSCDLTSETSDIQEP--YYGRVRAASAGSYSEWSMT- 70 80 90 100 110 120 130 140 150 160 pF1KE1 TRFS------VDEVTLTVGSVNLEIHNGFILGKIQLP----RPKMAPANDTYESIFSHFR ::. .: .... .:: . :: .:: . : . .: :: .. : NP_851 PRFTPWWETKIDPPVMNITQVNGSLL--VILHAPNLPYRYQKEKNVSIEDYYELLYRVFI 120 130 140 150 160 170 170 180 190 200 210 220 pF1KE1 EYEIAIRKVPGNFTFTHKKVKHENFSLLTSGEVGEFCVQV---KPSVASRSNKGMWSKEE . ...: . .:. :. : .. .: .:: . .: . ::.. :.:. NP_851 -INNSLEKEQKVYEGAHRAVEIEALTPHSS-----YCVVAEIYQPMLDRRSQR---SEER 180 190 200 210 220 230 240 250 260 270 280 pF1KE1 CISLTRQYFTVTNVIIFFAFVLLLSGALAYCLALQLYVRRRKKLPSVLLFKKPSPFIFIS :. . NP_851 CVEIP 230 >>NP_851827 (OMIM: 606648) interleukin-22 receptor subun (130 aa) initn: 114 init1: 54 opt: 188 Z-score: 176.5 bits: 40.4 E(85289): 0.0043 Smith-Waterman score: 188; 31.5% identity (62.9% similar) in 124 aa overlap (1-119:1-121) 10 20 30 40 50 pF1KE1 MLP--CLVVLLAALLSLRLGSDAHGTELPSPPSVWFEAEFFHHILHWTPIPNQS-ESTCY :.: :.. .: ... ... : .: : :... ::.::.: : . .:. : NP_851 MMPKHCFLGFLISFFLTGVAGTQSTHESLKPQRVQFQSRNFHNILQWQPGRALTGNSSVY 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE1 EVALLRYGIESWNSISNC--SQTLSYDLTAVTLDLYHSNGYRARVRAVDGSRHSNWTVTN : :: ..:.. .: .: :: :::. : :. .. : .::::.... .:.:..: NP_851 FVQYKIYGQRQWKNKEDCWGTQELSCDLTSETSDI--QEPYYGRVRAASAGSYSEWSMT- 70 80 90 100 110 120 130 140 150 160 170 pF1KE1 TRFSVDEVTLTVGSVNLEIHNGFILGKIQLPRPKMAPANDTYESIFSHFREYEIAIRKVP ::. NP_851 PRFTPWWERAKGL 120 130 578 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Mon Nov 7 00:21:19 2016 done: Mon Nov 7 00:21:21 2016 Total Scan time: 11.610 Total Display time: 0.020 Function used was FASTA [36.3.4 Apr, 2011]