FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE1437, 1011 aa 1>>>pF1KE1437 1011 - 1011 aa - 1011 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.9418+/-0.00109; mu= 18.0352+/- 0.065 mean_var=76.2751+/-15.284, 0's: 0 Z-trim(102.5): 93 B-trim: 0 in 0/52 Lambda= 0.146853 statistics sampled from 6872 (6969) to 6872 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.563), E-opt: 0.2 (0.214), width: 16 Scan time: 4.210 The best scores are: opt bits E(32554) CCDS42775.1 RAPGEF4 gene_id:11069|Hs108|chr2 (1011) 6692 1428.3 0 CCDS42776.1 RAPGEF4 gene_id:11069|Hs108|chr2 ( 867) 5725 1223.4 0 CCDS63060.1 RAPGEF4 gene_id:11069|Hs108|chr2 ( 858) 5681 1214.1 0 CCDS63061.1 RAPGEF4 gene_id:11069|Hs108|chr2 ( 840) 5382 1150.7 0 CCDS74604.1 RAPGEF4 gene_id:11069|Hs108|chr2 ( 791) 5238 1120.2 0 CCDS31784.1 RAPGEF3 gene_id:10411|Hs108|chr12 ( 881) 2667 575.5 1.7e-163 CCDS41775.1 RAPGEF3 gene_id:10411|Hs108|chr12 ( 923) 2667 575.5 1.7e-163 CCDS55093.1 RAPGEF5 gene_id:9771|Hs108|chr7 ( 730) 1729 376.7 9.3e-104 CCDS77023.1 RAPGEFL1 gene_id:51195|Hs108|chr17 ( 505) 1226 270.1 8.1e-72 CCDS77022.1 RAPGEFL1 gene_id:51195|Hs108|chr17 ( 511) 1221 269.0 1.7e-71 CCDS11363.1 RAPGEFL1 gene_id:51195|Hs108|chr17 ( 456) 1197 263.9 5.3e-70 CCDS54899.1 RAPGEF6 gene_id:51735|Hs108|chr5 (1504) 595 136.6 3.7e-31 CCDS54901.1 RAPGEF6 gene_id:51735|Hs108|chr5 (1509) 595 136.6 3.7e-31 CCDS54900.1 RAPGEF6 gene_id:51735|Hs108|chr5 (1609) 595 136.6 3.9e-31 CCDS43277.1 RAPGEF2 gene_id:9693|Hs108|chr4 (1499) 591 135.8 6.6e-31 CCDS54898.1 RAPGEF6 gene_id:51735|Hs108|chr5 (1391) 588 135.1 9.6e-31 CCDS34225.1 RAPGEF6 gene_id:51735|Hs108|chr5 (1601) 588 135.1 1.1e-30 CCDS48047.1 RAPGEF1 gene_id:2889|Hs108|chr9 (1077) 415 98.4 8.3e-20 CCDS78450.1 RAPGEF1 gene_id:2889|Hs108|chr9 (1094) 415 98.4 8.4e-20 CCDS48048.1 RAPGEF1 gene_id:2889|Hs108|chr9 (1095) 415 98.4 8.5e-20 CCDS54897.1 RAPGEF6 gene_id:51735|Hs108|chr5 ( 827) 364 87.6 1.2e-16 CCDS4052.1 RASGRF2 gene_id:5924|Hs108|chr5 (1237) 362 87.2 2.3e-16 CCDS42065.1 RASGRF1 gene_id:5923|Hs108|chr15 ( 489) 346 83.7 1.1e-15 CCDS45320.1 RASGRF1 gene_id:5923|Hs108|chr15 (1257) 346 83.8 2.4e-15 CCDS10309.1 RASGRF1 gene_id:5923|Hs108|chr15 (1273) 346 83.8 2.4e-15 CCDS1802.1 SOS1 gene_id:6654|Hs108|chr2 (1333) 328 80.0 3.6e-14 CCDS65733.1 RALGPS2 gene_id:55103|Hs108|chr1 ( 557) 310 76.1 2.3e-13 CCDS1325.1 RALGPS2 gene_id:55103|Hs108|chr1 ( 583) 310 76.1 2.4e-13 CCDS55344.1 RALGPS1 gene_id:9649|Hs108|chr9 ( 305) 300 73.8 6e-13 CCDS55346.1 RALGPS1 gene_id:9649|Hs108|chr9 ( 529) 300 73.9 9.7e-13 CCDS55345.1 RALGPS1 gene_id:9649|Hs108|chr9 ( 537) 300 73.9 9.8e-13 CCDS35143.1 RALGPS1 gene_id:9649|Hs108|chr9 ( 557) 300 73.9 1e-12 CCDS9697.1 SOS2 gene_id:6655|Hs108|chr14 (1332) 305 75.2 1e-12 CCDS4452.1 RASGEF1C gene_id:255426|Hs108|chr5 ( 466) 282 70.1 1.2e-11 CCDS75151.1 RASGEF1B gene_id:153020|Hs108|chr4 ( 431) 278 69.2 2e-11 CCDS75152.1 RASGEF1B gene_id:153020|Hs108|chr4 ( 472) 278 69.2 2.2e-11 CCDS34022.1 RASGEF1B gene_id:153020|Hs108|chr4 ( 473) 278 69.2 2.2e-11 >>CCDS42775.1 RAPGEF4 gene_id:11069|Hs108|chr2 (1011 aa) initn: 6692 init1: 6692 opt: 6692 Z-score: 7656.7 bits: 1428.3 E(32554): 0 Smith-Waterman score: 6692; 99.8% identity (99.8% similar) in 1011 aa overlap (1-1011:1-1011) 10 20 30 40 50 60 pF1KE1 MVAAHAAHSSSSAEWIACLDKRPLERSSEDVDIIFTRLKEVKAFEKFHPNLLHQICLCGY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 MVAAHAAHSSSSAEWIACLDKRPLERSSEDVDIIFTRLKEVKAFEKFHPNLLHQICLCGY 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 YENLEKGITLFRQGDIGTNWYAVLAGSLDVKVSETSSHQDAVTICTLGIGTAFGESILDN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 YENLEKGITLFRQGDIGTNWYAVLAGSLDVKVSETSSHQDAVTICTLGIGTAFGESILDN 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 TPRHATIVTRESSELLRIEQKDFKALWEKYRQYMAGLLAPPYGVMETGSNNDRIPDKENT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 TPRHATIVTRESSELLRIEQKDFKALWEKYRQYMAGLLAPPYGVMETGSNNDRIPDKENT 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 PLIEPHVPLRPANTITKVPSEKILRAGKILRNAILSRAPHMIRDRKYHLKTYRQCCVGTE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 PLIEPHVPLRPANTITKVPSEKILRAGKILRNAILSRAPHMIRDRKYHLKTYRQCCVGTE 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE1 LVDWMMQQTPCVHSRTQAVGMWQVLLEDGVLNHVDQEHHFQDKYLFYRFLDDEHEDAPLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 LVDWMMQQTPCVHSRTQAVGMWQVLLEDGVLNHVDQEHHFQDKYLFYRFLDDEHEDAPLP 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE1 TEEEKKECDEELQDTMLLLSQMGPDAHMRMILRKPPGQRTVDDLEIIYEELLHIKALSHL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 TEEEKKECDEELQDTMLLLSQMGPDAHMRMILRKPPGQRTVDDLEIIYEELLHIKALSHL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE1 STTVKRELAGVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEGDD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 STTVKRELAGVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEGDD 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE1 FGKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRILRDVEANTVRLKEHDQDVLVLEKV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 FGKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRILRDVEANTVRLKEHDQDVLVLEKV 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE1 PAGNRASNQGNSQPQQKYTVMSGTPEKILEHFLETIRLEATLNEATDSVLNDFIMMHCVF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 PAGNRASNQGNSQPQQKYTVMSGTPEKILEHFLETIRLEATLNEATDSVLNDFIMMHCVF 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE1 MPNTQLCPALVAHYHAQPSQGTEQEKMDYALNNKRRVIRLVLQWAAMYGDLLQEDDVSMA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 MPNTQLCPALVAHYHAQPSQGTEQEKMDYALNNKRRVIRLVLQWAAMYGDLLQEDDVSMA 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE1 FLEEFYVSVSDDARMIAALKEQLPELEKIVKQISEDAKAPQKKHKVLLQQFNTGDERAQK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 FLEEFYVSVSDDARMIAALKEQLPELEKIVKQISEDAKAPQKKHKVLLQQFNTGDERAQK 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE1 RQPIRGSDEVLFKVYCMDPTYTTIRVPVATSVKEVISAVADKLGSGEGLIIVKMSSGGEK :::::::::::::::::: ::::::::::::::::::::::::::::::::::::::::: CCDS42 RQPIRGSDEVLFKVYCMDHTYTTIRVPVATSVKEVISAVADKLGSGEGLIIVKMSSGGEK 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE1 VVLKPNDVSVFMTLTINGRLFACPREQFDSLTPLPEQEGPTVGTVGTFELMSSKDLAYQM ::::::::::: :::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 VVLKPNDVSVFTTLTINGRLFACPREQFDSLTPLPEQEGPTVGTVGTFELMSSKDLAYQM 730 740 750 760 770 780 790 800 810 820 830 840 pF1KE1 TIYDWELFNCVHELELIYHTFGRHNFKKTTANLDLFLRRFNEIQFWVVTEICLCSQLSKR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 TIYDWELFNCVHELELIYHTFGRHNFKKTTANLDLFLRRFNEIQFWVVTEICLCSQLSKR 790 800 810 820 830 840 850 860 870 880 890 900 pF1KE1 VQLLKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPSKFKKFYAEFESLM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 VQLLKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPSKFKKFYAEFESLM 850 860 870 880 890 900 910 920 930 940 950 960 pF1KE1 DPSRNHRAYRLTVAKLEPPLIPFMPLLIKDMTFTHEGNKTFIDNLVNFEKMRMIANTART :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 DPSRNHRAYRLTVAKLEPPLIPFMPLLIKDMTFTHEGNKTFIDNLVNFEKMRMIANTART 910 920 930 940 950 960 970 980 990 1000 1010 pF1KE1 VRYYRSQPFNPDAAQANKNHQDVRSYVRQLNVIDNQRTLSQMSHRLEPRRP ::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 VRYYRSQPFNPDAAQANKNHQDVRSYVRQLNVIDNQRTLSQMSHRLEPRRP 970 980 990 1000 1010 >>CCDS42776.1 RAPGEF4 gene_id:11069|Hs108|chr2 (867 aa) initn: 5725 init1: 5725 opt: 5725 Z-score: 6550.5 bits: 1223.4 E(32554): 0 Smith-Waterman score: 5725; 99.5% identity (99.8% similar) in 866 aa overlap (146-1011:2-867) 120 130 140 150 160 170 pF1KE1 SILDNTPRHATIVTRESSELLRIEQKDFKALWEKYRQYMAGLLAPPYGVMETGSNNDRIP :..::::::::::::::::::::::::::: CCDS42 MLYKKYRQYMAGLLAPPYGVMETGSNNDRIP 10 20 30 180 190 200 210 220 230 pF1KE1 DKENTPLIEPHVPLRPANTITKVPSEKILRAGKILRNAILSRAPHMIRDRKYHLKTYRQC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 DKENTPLIEPHVPLRPANTITKVPSEKILRAGKILRNAILSRAPHMIRDRKYHLKTYRQC 40 50 60 70 80 90 240 250 260 270 280 290 pF1KE1 CVGTELVDWMMQQTPCVHSRTQAVGMWQVLLEDGVLNHVDQEHHFQDKYLFYRFLDDEHE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 CVGTELVDWMMQQTPCVHSRTQAVGMWQVLLEDGVLNHVDQEHHFQDKYLFYRFLDDEHE 100 110 120 130 140 150 300 310 320 330 340 350 pF1KE1 DAPLPTEEEKKECDEELQDTMLLLSQMGPDAHMRMILRKPPGQRTVDDLEIIYEELLHIK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 DAPLPTEEEKKECDEELQDTMLLLSQMGPDAHMRMILRKPPGQRTVDDLEIIYEELLHIK 160 170 180 190 200 210 360 370 380 390 400 410 pF1KE1 ALSHLSTTVKRELAGVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 ALSHLSTTVKRELAGVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTL 220 230 240 250 260 270 420 430 440 450 460 470 pF1KE1 HEGDDFGKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRILRDVEANTVRLKEHDQDVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 HEGDDFGKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRILRDVEANTVRLKEHDQDVL 280 290 300 310 320 330 480 490 500 510 520 530 pF1KE1 VLEKVPAGNRASNQGNSQPQQKYTVMSGTPEKILEHFLETIRLEATLNEATDSVLNDFIM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 VLEKVPAGNRASNQGNSQPQQKYTVMSGTPEKILEHFLETIRLEATLNEATDSVLNDFIM 340 350 360 370 380 390 540 550 560 570 580 590 pF1KE1 MHCVFMPNTQLCPALVAHYHAQPSQGTEQEKMDYALNNKRRVIRLVLQWAAMYGDLLQED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 MHCVFMPNTQLCPALVAHYHAQPSQGTEQEKMDYALNNKRRVIRLVLQWAAMYGDLLQED 400 410 420 430 440 450 600 610 620 630 640 650 pF1KE1 DVSMAFLEEFYVSVSDDARMIAALKEQLPELEKIVKQISEDAKAPQKKHKVLLQQFNTGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 DVSMAFLEEFYVSVSDDARMIAALKEQLPELEKIVKQISEDAKAPQKKHKVLLQQFNTGD 460 470 480 490 500 510 660 670 680 690 700 710 pF1KE1 ERAQKRQPIRGSDEVLFKVYCMDPTYTTIRVPVATSVKEVISAVADKLGSGEGLIIVKMS ::::::::::::::::::::::: :::::::::::::::::::::::::::::::::::: CCDS42 ERAQKRQPIRGSDEVLFKVYCMDHTYTTIRVPVATSVKEVISAVADKLGSGEGLIIVKMS 520 530 540 550 560 570 720 730 740 750 760 770 pF1KE1 SGGEKVVLKPNDVSVFMTLTINGRLFACPREQFDSLTPLPEQEGPTVGTVGTFELMSSKD :::::::::::::::: ::::::::::::::::::::::::::::::::::::::::::: CCDS42 SGGEKVVLKPNDVSVFTTLTINGRLFACPREQFDSLTPLPEQEGPTVGTVGTFELMSSKD 580 590 600 610 620 630 780 790 800 810 820 830 pF1KE1 LAYQMTIYDWELFNCVHELELIYHTFGRHNFKKTTANLDLFLRRFNEIQFWVVTEICLCS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 LAYQMTIYDWELFNCVHELELIYHTFGRHNFKKTTANLDLFLRRFNEIQFWVVTEICLCS 640 650 660 670 680 690 840 850 860 870 880 890 pF1KE1 QLSKRVQLLKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPSKFKKFYAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 QLSKRVQLLKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPSKFKKFYAE 700 710 720 730 740 750 900 910 920 930 940 950 pF1KE1 FESLMDPSRNHRAYRLTVAKLEPPLIPFMPLLIKDMTFTHEGNKTFIDNLVNFEKMRMIA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 FESLMDPSRNHRAYRLTVAKLEPPLIPFMPLLIKDMTFTHEGNKTFIDNLVNFEKMRMIA 760 770 780 790 800 810 960 970 980 990 1000 1010 pF1KE1 NTARTVRYYRSQPFNPDAAQANKNHQDVRSYVRQLNVIDNQRTLSQMSHRLEPRRP :::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 NTARTVRYYRSQPFNPDAAQANKNHQDVRSYVRQLNVIDNQRTLSQMSHRLEPRRP 820 830 840 850 860 >>CCDS63060.1 RAPGEF4 gene_id:11069|Hs108|chr2 (858 aa) initn: 5681 init1: 5681 opt: 5681 Z-score: 6500.2 bits: 1214.1 E(32554): 0 Smith-Waterman score: 5681; 99.8% identity (99.8% similar) in 858 aa overlap (154-1011:1-858) 130 140 150 160 170 180 pF1KE1 HATIVTRESSELLRIEQKDFKALWEKYRQYMAGLLAPPYGVMETGSNNDRIPDKENTPLI :::::::::::::::::::::::::::::: CCDS63 MAGLLAPPYGVMETGSNNDRIPDKENTPLI 10 20 30 190 200 210 220 230 240 pF1KE1 EPHVPLRPANTITKVPSEKILRAGKILRNAILSRAPHMIRDRKYHLKTYRQCCVGTELVD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS63 EPHVPLRPANTITKVPSEKILRAGKILRNAILSRAPHMIRDRKYHLKTYRQCCVGTELVD 40 50 60 70 80 90 250 260 270 280 290 300 pF1KE1 WMMQQTPCVHSRTQAVGMWQVLLEDGVLNHVDQEHHFQDKYLFYRFLDDEHEDAPLPTEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS63 WMMQQTPCVHSRTQAVGMWQVLLEDGVLNHVDQEHHFQDKYLFYRFLDDEHEDAPLPTEE 100 110 120 130 140 150 310 320 330 340 350 360 pF1KE1 EKKECDEELQDTMLLLSQMGPDAHMRMILRKPPGQRTVDDLEIIYEELLHIKALSHLSTT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS63 EKKECDEELQDTMLLLSQMGPDAHMRMILRKPPGQRTVDDLEIIYEELLHIKALSHLSTT 160 170 180 190 200 210 370 380 390 400 410 420 pF1KE1 VKRELAGVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEGDDFGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS63 VKRELAGVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEGDDFGK 220 230 240 250 260 270 430 440 450 460 470 480 pF1KE1 LALVNDAPRAASIVLREDNCHFLRVDKEDFNRILRDVEANTVRLKEHDQDVLVLEKVPAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS63 LALVNDAPRAASIVLREDNCHFLRVDKEDFNRILRDVEANTVRLKEHDQDVLVLEKVPAG 280 290 300 310 320 330 490 500 510 520 530 540 pF1KE1 NRASNQGNSQPQQKYTVMSGTPEKILEHFLETIRLEATLNEATDSVLNDFIMMHCVFMPN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS63 NRASNQGNSQPQQKYTVMSGTPEKILEHFLETIRLEATLNEATDSVLNDFIMMHCVFMPN 340 350 360 370 380 390 550 560 570 580 590 600 pF1KE1 TQLCPALVAHYHAQPSQGTEQEKMDYALNNKRRVIRLVLQWAAMYGDLLQEDDVSMAFLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS63 TQLCPALVAHYHAQPSQGTEQEKMDYALNNKRRVIRLVLQWAAMYGDLLQEDDVSMAFLE 400 410 420 430 440 450 610 620 630 640 650 660 pF1KE1 EFYVSVSDDARMIAALKEQLPELEKIVKQISEDAKAPQKKHKVLLQQFNTGDERAQKRQP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS63 EFYVSVSDDARMIAALKEQLPELEKIVKQISEDAKAPQKKHKVLLQQFNTGDERAQKRQP 460 470 480 490 500 510 670 680 690 700 710 720 pF1KE1 IRGSDEVLFKVYCMDPTYTTIRVPVATSVKEVISAVADKLGSGEGLIIVKMSSGGEKVVL ::::::::::::::: :::::::::::::::::::::::::::::::::::::::::::: CCDS63 IRGSDEVLFKVYCMDHTYTTIRVPVATSVKEVISAVADKLGSGEGLIIVKMSSGGEKVVL 520 530 540 550 560 570 730 740 750 760 770 780 pF1KE1 KPNDVSVFMTLTINGRLFACPREQFDSLTPLPEQEGPTVGTVGTFELMSSKDLAYQMTIY :::::::: ::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS63 KPNDVSVFTTLTINGRLFACPREQFDSLTPLPEQEGPTVGTVGTFELMSSKDLAYQMTIY 580 590 600 610 620 630 790 800 810 820 830 840 pF1KE1 DWELFNCVHELELIYHTFGRHNFKKTTANLDLFLRRFNEIQFWVVTEICLCSQLSKRVQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS63 DWELFNCVHELELIYHTFGRHNFKKTTANLDLFLRRFNEIQFWVVTEICLCSQLSKRVQL 640 650 660 670 680 690 850 860 870 880 890 900 pF1KE1 LKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPSKFKKFYAEFESLMDPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS63 LKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPSKFKKFYAEFESLMDPS 700 710 720 730 740 750 910 920 930 940 950 960 pF1KE1 RNHRAYRLTVAKLEPPLIPFMPLLIKDMTFTHEGNKTFIDNLVNFEKMRMIANTARTVRY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS63 RNHRAYRLTVAKLEPPLIPFMPLLIKDMTFTHEGNKTFIDNLVNFEKMRMIANTARTVRY 760 770 780 790 800 810 970 980 990 1000 1010 pF1KE1 YRSQPFNPDAAQANKNHQDVRSYVRQLNVIDNQRTLSQMSHRLEPRRP :::::::::::::::::::::::::::::::::::::::::::::::: CCDS63 YRSQPFNPDAAQANKNHQDVRSYVRQLNVIDNQRTLSQMSHRLEPRRP 820 830 840 850 >>CCDS63061.1 RAPGEF4 gene_id:11069|Hs108|chr2 (840 aa) initn: 5382 init1: 5382 opt: 5382 Z-score: 6158.0 bits: 1150.7 E(32554): 0 Smith-Waterman score: 5514; 97.7% identity (97.7% similar) in 858 aa overlap (154-1011:1-840) 130 140 150 160 170 180 pF1KE1 HATIVTRESSELLRIEQKDFKALWEKYRQYMAGLLAPPYGVMETGSNNDRIPDKENTPLI :::::::::::::::::::::::::: CCDS63 MAGLLAPPYGVMETGSNNDRIPDKEN---- 10 20 190 200 210 220 230 240 pF1KE1 EPHVPLRPANTITKVPSEKILRAGKILRNAILSRAPHMIRDRKYHLKTYRQCCVGTELVD :::::::::::::::::::::::::::::::::::::::::::::: CCDS63 --------------VPSEKILRAGKILRNAILSRAPHMIRDRKYHLKTYRQCCVGTELVD 30 40 50 60 70 250 260 270 280 290 300 pF1KE1 WMMQQTPCVHSRTQAVGMWQVLLEDGVLNHVDQEHHFQDKYLFYRFLDDEHEDAPLPTEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS63 WMMQQTPCVHSRTQAVGMWQVLLEDGVLNHVDQEHHFQDKYLFYRFLDDEHEDAPLPTEE 80 90 100 110 120 130 310 320 330 340 350 360 pF1KE1 EKKECDEELQDTMLLLSQMGPDAHMRMILRKPPGQRTVDDLEIIYEELLHIKALSHLSTT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS63 EKKECDEELQDTMLLLSQMGPDAHMRMILRKPPGQRTVDDLEIIYEELLHIKALSHLSTT 140 150 160 170 180 190 370 380 390 400 410 420 pF1KE1 VKRELAGVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEGDDFGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS63 VKRELAGVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEGDDFGK 200 210 220 230 240 250 430 440 450 460 470 480 pF1KE1 LALVNDAPRAASIVLREDNCHFLRVDKEDFNRILRDVEANTVRLKEHDQDVLVLEKVPAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS63 LALVNDAPRAASIVLREDNCHFLRVDKEDFNRILRDVEANTVRLKEHDQDVLVLEKVPAG 260 270 280 290 300 310 490 500 510 520 530 540 pF1KE1 NRASNQGNSQPQQKYTVMSGTPEKILEHFLETIRLEATLNEATDSVLNDFIMMHCVFMPN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS63 NRASNQGNSQPQQKYTVMSGTPEKILEHFLETIRLEATLNEATDSVLNDFIMMHCVFMPN 320 330 340 350 360 370 550 560 570 580 590 600 pF1KE1 TQLCPALVAHYHAQPSQGTEQEKMDYALNNKRRVIRLVLQWAAMYGDLLQEDDVSMAFLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS63 TQLCPALVAHYHAQPSQGTEQEKMDYALNNKRRVIRLVLQWAAMYGDLLQEDDVSMAFLE 380 390 400 410 420 430 610 620 630 640 650 660 pF1KE1 EFYVSVSDDARMIAALKEQLPELEKIVKQISEDAKAPQKKHKVLLQQFNTGDERAQKRQP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS63 EFYVSVSDDARMIAALKEQLPELEKIVKQISEDAKAPQKKHKVLLQQFNTGDERAQKRQP 440 450 460 470 480 490 670 680 690 700 710 720 pF1KE1 IRGSDEVLFKVYCMDPTYTTIRVPVATSVKEVISAVADKLGSGEGLIIVKMSSGGEKVVL ::::::::::::::: :::::::::::::::::::::::::::::::::::::::::::: CCDS63 IRGSDEVLFKVYCMDHTYTTIRVPVATSVKEVISAVADKLGSGEGLIIVKMSSGGEKVVL 500 510 520 530 540 550 730 740 750 760 770 780 pF1KE1 KPNDVSVFMTLTINGRLFACPREQFDSLTPLPEQEGPTVGTVGTFELMSSKDLAYQMTIY :::::::: ::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS63 KPNDVSVFTTLTINGRLFACPREQFDSLTPLPEQEGPTVGTVGTFELMSSKDLAYQMTIY 560 570 580 590 600 610 790 800 810 820 830 840 pF1KE1 DWELFNCVHELELIYHTFGRHNFKKTTANLDLFLRRFNEIQFWVVTEICLCSQLSKRVQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS63 DWELFNCVHELELIYHTFGRHNFKKTTANLDLFLRRFNEIQFWVVTEICLCSQLSKRVQL 620 630 640 650 660 670 850 860 870 880 890 900 pF1KE1 LKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPSKFKKFYAEFESLMDPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS63 LKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPSKFKKFYAEFESLMDPS 680 690 700 710 720 730 910 920 930 940 950 960 pF1KE1 RNHRAYRLTVAKLEPPLIPFMPLLIKDMTFTHEGNKTFIDNLVNFEKMRMIANTARTVRY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS63 RNHRAYRLTVAKLEPPLIPFMPLLIKDMTFTHEGNKTFIDNLVNFEKMRMIANTARTVRY 740 750 760 770 780 790 970 980 990 1000 1010 pF1KE1 YRSQPFNPDAAQANKNHQDVRSYVRQLNVIDNQRTLSQMSHRLEPRRP :::::::::::::::::::::::::::::::::::::::::::::::: CCDS63 YRSQPFNPDAAQANKNHQDVRSYVRQLNVIDNQRTLSQMSHRLEPRRP 800 810 820 830 840 >>CCDS74604.1 RAPGEF4 gene_id:11069|Hs108|chr2 (791 aa) initn: 5238 init1: 5238 opt: 5238 Z-score: 5993.5 bits: 1120.2 E(32554): 0 Smith-Waterman score: 5238; 99.7% identity (99.7% similar) in 791 aa overlap (221-1011:1-791) 200 210 220 230 240 250 pF1KE1 PANTITKVPSEKILRAGKILRNAILSRAPHMIRDRKYHLKTYRQCCVGTELVDWMMQQTP :::::::::::::::::::::::::::::: CCDS74 MIRDRKYHLKTYRQCCVGTELVDWMMQQTP 10 20 30 260 270 280 290 300 310 pF1KE1 CVHSRTQAVGMWQVLLEDGVLNHVDQEHHFQDKYLFYRFLDDEHEDAPLPTEEEKKECDE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS74 CVHSRTQAVGMWQVLLEDGVLNHVDQEHHFQDKYLFYRFLDDEHEDAPLPTEEEKKECDE 40 50 60 70 80 90 320 330 340 350 360 370 pF1KE1 ELQDTMLLLSQMGPDAHMRMILRKPPGQRTVDDLEIIYEELLHIKALSHLSTTVKRELAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS74 ELQDTMLLLSQMGPDAHMRMILRKPPGQRTVDDLEIIYEELLHIKALSHLSTTVKRELAG 100 110 120 130 140 150 380 390 400 410 420 430 pF1KE1 VLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEGDDFGKLALVNDA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS74 VLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEGDDFGKLALVNDA 160 170 180 190 200 210 440 450 460 470 480 490 pF1KE1 PRAASIVLREDNCHFLRVDKEDFNRILRDVEANTVRLKEHDQDVLVLEKVPAGNRASNQG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS74 PRAASIVLREDNCHFLRVDKEDFNRILRDVEANTVRLKEHDQDVLVLEKVPAGNRASNQG 220 230 240 250 260 270 500 510 520 530 540 550 pF1KE1 NSQPQQKYTVMSGTPEKILEHFLETIRLEATLNEATDSVLNDFIMMHCVFMPNTQLCPAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS74 NSQPQQKYTVMSGTPEKILEHFLETIRLEATLNEATDSVLNDFIMMHCVFMPNTQLCPAL 280 290 300 310 320 330 560 570 580 590 600 610 pF1KE1 VAHYHAQPSQGTEQEKMDYALNNKRRVIRLVLQWAAMYGDLLQEDDVSMAFLEEFYVSVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS74 VAHYHAQPSQGTEQEKMDYALNNKRRVIRLVLQWAAMYGDLLQEDDVSMAFLEEFYVSVS 340 350 360 370 380 390 620 630 640 650 660 670 pF1KE1 DDARMIAALKEQLPELEKIVKQISEDAKAPQKKHKVLLQQFNTGDERAQKRQPIRGSDEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS74 DDARMIAALKEQLPELEKIVKQISEDAKAPQKKHKVLLQQFNTGDERAQKRQPIRGSDEV 400 410 420 430 440 450 680 690 700 710 720 730 pF1KE1 LFKVYCMDPTYTTIRVPVATSVKEVISAVADKLGSGEGLIIVKMSSGGEKVVLKPNDVSV :::::::: ::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS74 LFKVYCMDHTYTTIRVPVATSVKEVISAVADKLGSGEGLIIVKMSSGGEKVVLKPNDVSV 460 470 480 490 500 510 740 750 760 770 780 790 pF1KE1 FMTLTINGRLFACPREQFDSLTPLPEQEGPTVGTVGTFELMSSKDLAYQMTIYDWELFNC : :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS74 FTTLTINGRLFACPREQFDSLTPLPEQEGPTVGTVGTFELMSSKDLAYQMTIYDWELFNC 520 530 540 550 560 570 800 810 820 830 840 850 pF1KE1 VHELELIYHTFGRHNFKKTTANLDLFLRRFNEIQFWVVTEICLCSQLSKRVQLLKKFIKI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS74 VHELELIYHTFGRHNFKKTTANLDLFLRRFNEIQFWVVTEICLCSQLSKRVQLLKKFIKI 580 590 600 610 620 630 860 870 880 890 900 910 pF1KE1 AAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPSKFKKFYAEFESLMDPSRNHRAYR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS74 AAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPSKFKKFYAEFESLMDPSRNHRAYR 640 650 660 670 680 690 920 930 940 950 960 970 pF1KE1 LTVAKLEPPLIPFMPLLIKDMTFTHEGNKTFIDNLVNFEKMRMIANTARTVRYYRSQPFN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS74 LTVAKLEPPLIPFMPLLIKDMTFTHEGNKTFIDNLVNFEKMRMIANTARTVRYYRSQPFN 700 710 720 730 740 750 980 990 1000 1010 pF1KE1 PDAAQANKNHQDVRSYVRQLNVIDNQRTLSQMSHRLEPRRP ::::::::::::::::::::::::::::::::::::::::: CCDS74 PDAAQANKNHQDVRSYVRQLNVIDNQRTLSQMSHRLEPRRP 760 770 780 790 >>CCDS31784.1 RAPGEF3 gene_id:10411|Hs108|chr12 (881 aa) initn: 2380 init1: 846 opt: 2667 Z-score: 3049.0 bits: 575.5 E(32554): 1.7e-163 Smith-Waterman score: 2717; 49.6% identity (76.4% similar) in 857 aa overlap (180-1008:32-881) 150 160 170 180 190 200 pF1KE1 YRQYMAGLLAPPYGVMETGSNNDRIPDKENTPLIEPHVPLRPANTITKVPSEKILRAGKI ::: . . : .... .. .:..::::. CCDS31 VLRRMHRPRSCSYQLLLEHQRPSCIQGLRWTPLTNSEESLDFSESLEQASTERVLRAGRQ 10 20 30 40 50 60 210 220 230 240 250 260 pF1KE1 LRNAILSRAPHMIRDRKYHLKTYRQCCVGTELVDWMMQQTPCVHSRTQAVGMWQVLLEDG :. .:. :..::::::::. ::::: : :::: .. ::::.:.::. ::::..: CCDS31 LHRHLLATCPNLIRDRKYHLRLYRQCCSGRELVDGILALGLGVHSRSQVVGICQVLLDEG 70 80 90 100 110 120 270 280 290 300 310 320 pF1KE1 VLNHVDQEHHFQDK-YLFYRFLDDEHEDAPLPTEEEKKECDEELQDTMLLLSQMGPDAHM .: :: .. :::. :::: .: : . .: .::: ... :::: :::: . CCDS31 ALCHVKHDWAFQDRDAQFYRF------PGPEPEPVRTHEMEEELAEAVALLSQRGPDALL 130 140 150 160 170 330 340 350 360 370 380 pF1KE1 RMILRKPPGQRTVDDLEIIYEELLHIKALSHLSTTVKRELAGVLIFESHAKGGTVLFNQG . ::::::::: ..:..:.::::::::..:::..::::::.::.:: :.:.:::::.:: CCDS31 TVALRKPPGQRTDEELDLIFEELLHIKAVAHLSNSVKRELAAVLLFEPHSKAGTVLFSQG 180 190 200 210 220 230 390 400 410 420 430 440 pF1KE1 EEGTSWYIILKGSVNVVIYGKGVVCTLHEGDDFGKLALVNDAPRAASIVLREDNCHFLRV ..::::::: ::::::: .:::.: :::::::::.:::::::::::.:.::::::::::: CCDS31 DKGTSWYIIWKGSVNVVTHGKGLVTTLHEGDDFGQLALVNDAPRAATIILREDNCHFLRV 240 250 260 270 280 290 450 460 470 480 490 500 pF1KE1 DKEDFNRILRDVEANTVRLKEHDQDVLVLEKVPAGNRASNQGNSQPQQKYTVMSGTPEKI ::.:::::..::::.:.::.:: . :::::.. : : . . ...::::::::::: CCDS31 DKQDFNRIIKDVEAKTMRLEEHGKVVLVLERASQGAGPS-RPPTPGRNRYTVMSGTPEKI 300 310 320 330 340 350 510 520 530 540 550 560 pF1KE1 LEHFLETIRLEATLNEATDSVLNDFIMMHCVFMPNTQLCPALVAHYHAQPSQGTEQEKMD :: .::.. ... .. :.. :.::.. : ::::..::: ::. :.:..:. :.:::. CCDS31 LELLLEAMGPDSSAHDPTETFLSDFLLTHRVFMPSAQLCAALLHHFHVEPAGGSEQERST 360 370 380 390 400 410 570 580 590 600 610 620 pF1KE1 YALNNKRRVIRLVLQWAAMYGDLLQEDDVSMAFLEEFYVSVSDDARMIAALKEQLPELEK :. :......::: ::.:.::..:. : :. .::... :. :.:. :.:: :: .. CCDS31 YVCNKRQQILRLVSQWVALYGSMLHTDPVATSFLQKLSDLVGRDTRLSNLLREQWPERRR 420 430 440 450 460 470 630 640 650 660 670 680 pF1KE1 IVK-QISEDAKAPQKKHKVLLQQFNTGDERAQKRQ-PIRGSDEVLFKVYCMDPTYTTIRV . . . .:: : . : . . :: . :. .:.: . . : . :... CCDS31 CHRLENGCGNASPQMKARNLPVWLPNQDEPLPGSSCAIQVGDKVPYDICRPDHSVLTLQL 480 490 500 510 520 530 690 700 710 720 730 740 pF1KE1 PVATSVKEVISAVADKLGSGEGLIIVKMSSGGEKVVLKPNDVSVFMTLTINGRLFACPRE ::..::.::..:.:.. : .: ..::..:.:. . :.:. .: .: .: :::. . CCDS31 PVTASVREVMAALAQEDGWTKGQVLVKVNSAGDAIGLQPDARGVATSLGLNERLFVVNPQ 540 550 560 570 580 590 750 760 770 780 790 800 pF1KE1 QFDSLTPLPEQEGPTVGTVGTFELMSSKDLAYQMTIYDWELFNCVHELELIYHTFGRHNF . : : :.: :::::.. ..:.:.:::: :.: .:: ::: .:..:::....: ... CCDS31 EVHELIPHPDQLGPTVGSAEGLDLVSAKDLAGQLTDHDWSLFNSIHQVELIHYVLGPQHL 600 610 620 630 640 650 810 820 830 840 850 860 pF1KE1 KK-TTANLDLFLRRFNEIQFWVVTEICLCSQLSKRVQLLKKFIKIAAHCKEYKNLNSFFA . :::::. :.:::::.:.::.::.::: . :.:::.::::.::: :: :::::::: CCDS31 RDVTTANLERFMRRFNELQYWVATELCLCPVPGPRAQLLRKFIKLAAHLKEQKNLNSFFA 660 670 680 690 700 710 870 880 890 900 910 920 pF1KE1 IVMGLSNVAVSRLALTWEKLPSKFKKFYAEFESLMDPSRNHRAYRLTVAKLEPPLIPFMP ...:::: :.:::: :::.:: : .:.:. .: :.::: :::.:::..::: ::.::::: CCDS31 VMFGLSNSAISRLAHTWERLPHKVRKLYSALERLLDPSWNHRVYRLALAKLSPPVIPFMP 720 730 740 750 760 770 930 940 950 960 970 980 pF1KE1 LLIKDMTFTHEGNKTFIDNLVNFEKMRMIANTARTVRYYRSQ---PFNPDAAQANKNHQD ::.::::: ::::.:...::.:::::::.: .:: ... ::. :..: ..... :.: CCDS31 LLLKDMTFIHEGNHTLVENLINFEKMRMMARAARMLHHCRSHNPVPLSPLRSRVSHLHED 780 790 800 810 820 830 990 1000 1010 pF1KE1 ---------------VRS------YVRQLNVIDNQRTLSQMSHRLEPRRP .:: ::.::.:::::: ::..:..::: CCDS31 SQVARISTCSEQSLSTRSPASTWAYVQQLKVIDNQRELSRLSRELEP 840 850 860 870 880 >>CCDS41775.1 RAPGEF3 gene_id:10411|Hs108|chr12 (923 aa) initn: 2380 init1: 846 opt: 2667 Z-score: 3048.7 bits: 575.5 E(32554): 1.7e-163 Smith-Waterman score: 2717; 49.6% identity (76.4% similar) in 857 aa overlap (180-1008:74-923) 150 160 170 180 190 200 pF1KE1 YRQYMAGLLAPPYGVMETGSNNDRIPDKENTPLIEPHVPLRPANTITKVPSEKILRAGKI ::: . . : .... .. .:..::::. CCDS41 VLRRMHRPRSCSYQLLLEHQRPSCIQGLRWTPLTNSEESLDFSESLEQASTERVLRAGRQ 50 60 70 80 90 100 210 220 230 240 250 260 pF1KE1 LRNAILSRAPHMIRDRKYHLKTYRQCCVGTELVDWMMQQTPCVHSRTQAVGMWQVLLEDG :. .:. :..::::::::. ::::: : :::: .. ::::.:.::. ::::..: CCDS41 LHRHLLATCPNLIRDRKYHLRLYRQCCSGRELVDGILALGLGVHSRSQVVGICQVLLDEG 110 120 130 140 150 160 270 280 290 300 310 320 pF1KE1 VLNHVDQEHHFQDK-YLFYRFLDDEHEDAPLPTEEEKKECDEELQDTMLLLSQMGPDAHM .: :: .. :::. :::: .: : . .: .::: ... :::: :::: . CCDS41 ALCHVKHDWAFQDRDAQFYRF------PGPEPEPVRTHEMEEELAEAVALLSQRGPDALL 170 180 190 200 210 330 340 350 360 370 380 pF1KE1 RMILRKPPGQRTVDDLEIIYEELLHIKALSHLSTTVKRELAGVLIFESHAKGGTVLFNQG . ::::::::: ..:..:.::::::::..:::..::::::.::.:: :.:.:::::.:: CCDS41 TVALRKPPGQRTDEELDLIFEELLHIKAVAHLSNSVKRELAAVLLFEPHSKAGTVLFSQG 220 230 240 250 260 270 390 400 410 420 430 440 pF1KE1 EEGTSWYIILKGSVNVVIYGKGVVCTLHEGDDFGKLALVNDAPRAASIVLREDNCHFLRV ..::::::: ::::::: .:::.: :::::::::.:::::::::::.:.::::::::::: CCDS41 DKGTSWYIIWKGSVNVVTHGKGLVTTLHEGDDFGQLALVNDAPRAATIILREDNCHFLRV 280 290 300 310 320 330 450 460 470 480 490 500 pF1KE1 DKEDFNRILRDVEANTVRLKEHDQDVLVLEKVPAGNRASNQGNSQPQQKYTVMSGTPEKI ::.:::::..::::.:.::.:: . :::::.. : : . . ...::::::::::: CCDS41 DKQDFNRIIKDVEAKTMRLEEHGKVVLVLERASQGAGPS-RPPTPGRNRYTVMSGTPEKI 340 350 360 370 380 390 510 520 530 540 550 560 pF1KE1 LEHFLETIRLEATLNEATDSVLNDFIMMHCVFMPNTQLCPALVAHYHAQPSQGTEQEKMD :: .::.. ... .. :.. :.::.. : ::::..::: ::. :.:..:. :.:::. CCDS41 LELLLEAMGPDSSAHDPTETFLSDFLLTHRVFMPSAQLCAALLHHFHVEPAGGSEQERST 400 410 420 430 440 450 570 580 590 600 610 620 pF1KE1 YALNNKRRVIRLVLQWAAMYGDLLQEDDVSMAFLEEFYVSVSDDARMIAALKEQLPELEK :. :......::: ::.:.::..:. : :. .::... :. :.:. :.:: :: .. CCDS41 YVCNKRQQILRLVSQWVALYGSMLHTDPVATSFLQKLSDLVGRDTRLSNLLREQWPERRR 460 470 480 490 500 510 630 640 650 660 670 680 pF1KE1 IVK-QISEDAKAPQKKHKVLLQQFNTGDERAQKRQ-PIRGSDEVLFKVYCMDPTYTTIRV . . . .:: : . : . . :: . :. .:.: . . : . :... CCDS41 CHRLENGCGNASPQMKARNLPVWLPNQDEPLPGSSCAIQVGDKVPYDICRPDHSVLTLQL 520 530 540 550 560 570 690 700 710 720 730 740 pF1KE1 PVATSVKEVISAVADKLGSGEGLIIVKMSSGGEKVVLKPNDVSVFMTLTINGRLFACPRE ::..::.::..:.:.. : .: ..::..:.:. . :.:. .: .: .: :::. . CCDS41 PVTASVREVMAALAQEDGWTKGQVLVKVNSAGDAIGLQPDARGVATSLGLNERLFVVNPQ 580 590 600 610 620 630 750 760 770 780 790 800 pF1KE1 QFDSLTPLPEQEGPTVGTVGTFELMSSKDLAYQMTIYDWELFNCVHELELIYHTFGRHNF . : : :.: :::::.. ..:.:.:::: :.: .:: ::: .:..:::....: ... CCDS41 EVHELIPHPDQLGPTVGSAEGLDLVSAKDLAGQLTDHDWSLFNSIHQVELIHYVLGPQHL 640 650 660 670 680 690 810 820 830 840 850 860 pF1KE1 KK-TTANLDLFLRRFNEIQFWVVTEICLCSQLSKRVQLLKKFIKIAAHCKEYKNLNSFFA . :::::. :.:::::.:.::.::.::: . :.:::.::::.::: :: :::::::: CCDS41 RDVTTANLERFMRRFNELQYWVATELCLCPVPGPRAQLLRKFIKLAAHLKEQKNLNSFFA 700 710 720 730 740 750 870 880 890 900 910 920 pF1KE1 IVMGLSNVAVSRLALTWEKLPSKFKKFYAEFESLMDPSRNHRAYRLTVAKLEPPLIPFMP ...:::: :.:::: :::.:: : .:.:. .: :.::: :::.:::..::: ::.::::: CCDS41 VMFGLSNSAISRLAHTWERLPHKVRKLYSALERLLDPSWNHRVYRLALAKLSPPVIPFMP 760 770 780 790 800 810 930 940 950 960 970 980 pF1KE1 LLIKDMTFTHEGNKTFIDNLVNFEKMRMIANTARTVRYYRSQ---PFNPDAAQANKNHQD ::.::::: ::::.:...::.:::::::.: .:: ... ::. :..: ..... :.: CCDS41 LLLKDMTFIHEGNHTLVENLINFEKMRMMARAARMLHHCRSHNPVPLSPLRSRVSHLHED 820 830 840 850 860 870 990 1000 1010 pF1KE1 ---------------VRS------YVRQLNVIDNQRTLSQMSHRLEPRRP .:: ::.::.:::::: ::..:..::: CCDS41 SQVARISTCSEQSLSTRSPASTWAYVQQLKVIDNQRELSRLSRELEP 880 890 900 910 920 >>CCDS55093.1 RAPGEF5 gene_id:9771|Hs108|chr7 (730 aa) initn: 1531 init1: 959 opt: 1729 Z-score: 1976.2 bits: 376.7 E(32554): 9.3e-104 Smith-Waterman score: 1904; 42.5% identity (72.8% similar) in 757 aa overlap (258-1009:2-729) 230 240 250 260 270 280 pF1KE1 HLKTYRQCCVGTELVDWMMQQTPCVHSRTQAVGMWQVLLEDGVLNHVDQEHHFQDKYLFY :.:.::.::. :.. :::. .::: :.:: CCDS55 MAIGVWQLLLDMGIMLSVDQHLYFQDTYVFY 10 20 30 290 300 310 320 330 340 pF1KE1 RFLDDEHEDAPLPTEEEKKECDEELQDTMLLLSQMGPDAHMRMILRKPPGQRTVDDLEII .: .:: . : : :. .:: :. . :: :. : : . . :. ..: : CCDS55 QFSSDEC--SYLYCEFER---EEEWQNGVKLLLQLVPLIPARGGICELSHQK-IEDSEES 40 50 60 70 80 350 360 370 380 390 400 pF1KE1 YEELLHIKALSHLSTTVKRELAGVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIY .:. : .:...:.::::.:. .... .. ..: ::... .. . . .: CCDS55 SDEI-----LVRLTSAVQRELAAVIALKARKSA----IEQDEENNDKHVAVTEAESVPDS 90 100 110 120 130 410 420 430 440 450 460 pF1KE1 GKGVVCTLHEGDDFGKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRIL-RDVEANTVR ::.: :.: :..:.. ::. : ..: .::..::.. .. .: :..::. CCDS55 QAGVMCKLQERDEIGRIELVQK--------LAKENYQFLQTDKKEQEKSEHQDDEVTTVQ 140 150 160 170 180 470 480 490 500 510 520 pF1KE1 LKEHDQDVLVLEKVPAGNRASNQGNSQPQQKYTVMSGTPEKILEHFLETIRLEATLNEAT .::.::.::::.:: . : . :... . .:.:.::::::::::.:. ..:: . .. : CCDS55 VKEQDQSVLVLKKVQCCGPAPTAGSAESHWRYVVVSGTPEKILEHLLNDLHLEEVQDKET 190 200 210 220 230 240 530 540 550 560 570 580 pF1KE1 DSVLNDFIMMHCVFMPNTQLCPALVAHYHAQPSQGTEQEKMDYALNNKRRVIRLVLQWAA ...:.::.. . ::: . .:: ::. :: :. :: : :. : ::.:..:: :: : CCDS55 ETLLDDFLLTYTVFMTTDDLCQALLRHYSAKKYQGKE-ENSDVP-RRKRKVLHLVSQWIA 250 260 270 280 290 300 590 600 610 620 630 640 pF1KE1 MYGDLLQEDDVSMAFLEEFYVSVSDDARMIAALKEQLPELEKIV---KQISEDAKAPQKK .: : : ::. : ::. .: .: ::. :...: :..::. .. . : .:::: CCDS55 LYKDWLPEDEHSKMFLKTIYRNVLDDVYEYPILEKELKEFQKILGMHRRHTVDEYSPQKK 310 320 330 340 350 360 650 660 670 680 690 700 pF1KE1 HKVLLQQFNTGDERAQKRQPIRGSDEVLFKVYCMDPTYTTIRVPVATSVKEVISAVADKL .:.:..::. .. :.: . ..:.. .:: . .:..... :.. ..:....::.:. CCDS55 NKALFHQFSLKENWLQHRGTVTETEEIFCHVYITEHSYVSVKAKVSSIAQEILKVVAEKI 370 380 390 400 410 420 710 720 730 740 750 760 pF1KE1 GSGE-GLIIVKMSSGGEKVVLKPNDVSVFMTLTINGRLFACPREQFDSLTPLPEQEGPTV .: : .: .. .::: :.:::. . .: .::... .. :.:.:. :.: CCDS55 QYAEEDLALVAITFSGEKHELQPNDLVISKSLEASGRIYVYRKDLADTLNPFAENEESQQ 430 440 450 460 470 480 770 780 790 800 810 820 pF1KE1 GTVGTFELMSSKDLAYQMTIYDWELFNCVHELELIYHTFGRHNFKKTTANLDLFLRRFNE .. . :.. ::: .. .:: ::: .:: :::: ::.:.. . ::::.:.:.: :: CCDS55 RSMRILG-MNTWDLALELMNFDWSLFNSIHEQELIYFTFSRQGSGEHTANLSLLLQRCNE 490 500 510 520 530 540 830 840 850 860 870 880 pF1KE1 IQFWVVTEICLCSQLSKRVQLLKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTW .:.::.::: :::::.:::::.::::::::::: .::::::::::::....::::. :: CCDS55 VQLWVATEILLCSQLGKRVQLVKKFIKIAAHCKAQRNLNSFFAIVMGLNTASVSRLSQTW 550 560 570 580 590 600 890 900 910 920 930 940 pF1KE1 EKLPSKFKKFYAEFESLMDPSRNHRAYRLTVAKLEPPLIPFMPLLIKDMTFTHEGNKTFI ::.:.::::...:.::: ::: ::.::: . :..:: :::::::.::.:: :::::::. CCDS55 EKIPGKFKKLFSELESLTDPSLNHKAYRDAFKKMKPPKIPFMPLLLKDVTFIHEGNKTFL 610 620 630 640 650 660 950 960 970 980 990 1000 pF1KE1 DNLVNFEKMRMIANTARTVRYYRSQPFNPDAAQANKNHQDVRSYVRQLNVIDNQRTLSQM ::::::::..:::.:.::.:. :.. :. : . :.::...::: .: :::.:..: .. CCDS55 DNLVNFEKLHMIADTVRTLRHCRTNQFG-DLSP--KEHQELKSYVNHLYVIDSQQALFEL 670 680 690 700 710 720 1010 pF1KE1 SHRLEPRRP :::.::: CCDS55 SHRIEPRV 730 >>CCDS77023.1 RAPGEFL1 gene_id:51195|Hs108|chr17 (505 aa) initn: 1141 init1: 760 opt: 1226 Z-score: 1402.8 bits: 270.1 E(32554): 8.1e-72 Smith-Waterman score: 1300; 41.5% identity (74.0% similar) in 492 aa overlap (527-1007:17-501) 500 510 520 530 540 550 pF1KE1 KYTVMSGTPEKILEHFLETIRLEATLNEATDSVLNDFIMMHCVFMPNTQLCPALVAHYHA : .:.:... : .:.:. .. : : . CCDS77 MMLRPGYPLSQESFPIDILLDDIVLTHSLFLPTEKFLQEL--HQYF 10 20 30 40 560 570 580 590 600 610 pF1KE1 QPSQGTEQEKMDYALNNKRRVIRLVLQWAAMYGDLLQEDDVSMAFLEEFYVSVSDDARMI . : : . .:. :. . ..:.. : ::::.. . .....:. . : . CCDS77 VRAGGMEGPE---GLGRKQACLAMLLHFLDTYQGLLQEEEGAGHIIKDLYLLIMKDESLY 50 60 70 80 90 100 620 630 640 650 660 670 pF1KE1 AALKEQLPELEKIVK----QISEDAKAPQKKHKVLLQQFNTGDERAQKRQPIRGSDEVLF .:.:. .:...:. .: :. . :.:. : :...: : : : .:::::.. CCDS77 QGLREDTLRLHQLVETVELKIPEENQPPSKQVKPLFRHFRRIDSCLQTRVAFRGSDEIFC 110 120 130 140 150 160 680 690 700 710 720 pF1KE1 KVYCMDPTYTTIRVPVATSVKEVISAVADKL-------GSGEGLIIVKMSSGGEKVVLKP .:: : .:.::: ...::......:..:: : ..::.: .::.::::.:.: CCDS77 RVYMPDHSYVTIRSRLSASVQDILGSVTEKLQYSEEPAGREDSLILVAVSSSGEKVLLQP 170 180 190 200 210 220 730 740 750 760 770 780 pF1KE1 NDVSVFMTLTINGRLFACPREQFDSLTPLPEQEGPTVGTVGTFELMSSKDLAYQMTIYDW .. :: .: ::..:::: :.....:.::::. . : . .. . .:.: ..: . : CCDS77 TEDCVFTALGINSHLFACTRDSYEALVPLPEEIQVSPGDT-EIHRVEPEDVANHLTAFHW 230 240 250 260 270 280 790 800 810 820 830 840 pF1KE1 ELFNCVHELELIYHTFGRHNFKKTTANLDLFLRRFNEIQFWVVTEICLCSQLSKRVQLLK ::: ::::::.. ..: . .. ::::.:.:.: .:. ::.::. :: .::.:::: CCDS77 ELFRCVHELEFVDYVFHGERGRRETANLELLLQRCSEVTHWVATEVLLCEAPGKRAQLLK 290 300 310 320 330 340 850 860 870 880 890 900 pF1KE1 KFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPSKFKKFYAEFESLMDPSRN ::::::: ::. ..: ::.:.::::.:.::::: :::::::.:::... .::.: :: :: CCDS77 KFIKIAALCKQNQDLLSFYAVVMGLDNAAVSRLRLTWEKLPGKFKNLFRKFENLTDPCRN 350 360 370 380 390 400 910 920 930 940 950 960 pF1KE1 HRAYRLTVAKLEPPLIPFMPLLIKDMTFTHEGNKTFIDNLVNFEKMRMIANTARTVRYYR :..:: ...:..::.:::.::..::.:: :::.::..:.:::.::.. .:. .::.: :: CCDS77 HKSYREVISKMKPPVIPFVPLILKDLTFLHEGSKTLVDGLVNIEKLHSVAEKVRTIRKYR 410 420 430 440 450 460 970 980 990 1000 1010 pF1KE1 SQPFNPDAAQANKNHQDVRSYVRQLNVIDNQRTLSQMSHRLEPRRP :.:. : .:. :: ....::::..::::: : ..:..:: CCDS77 SRPLCLDM-EASPNHLQTKAYVRQFQVIDNQNLLFELSYKLEANSQ 470 480 490 500 >>CCDS77022.1 RAPGEFL1 gene_id:51195|Hs108|chr17 (511 aa) initn: 1141 init1: 760 opt: 1221 Z-score: 1397.0 bits: 269.0 E(32554): 1.7e-71 Smith-Waterman score: 1295; 41.4% identity (74.1% similar) in 490 aa overlap (529-1007:25-507) 500 510 520 530 540 550 pF1KE1 TVMSGTPEKILEHFLETIRLEATLNEATDSVLNDFIMMHCVFMPNTQLCPALVAHYHAQP .:.:... : .:.:. .. : : . CCDS77 MLIHPRGLPSSSHRRKINSTYFYILLDDIVLTHSLFLPTEKFLQEL--HQYFVR 10 20 30 40 50 560 570 580 590 600 610 pF1KE1 SQGTEQEKMDYALNNKRRVIRLVLQWAAMYGDLLQEDDVSMAFLEEFYVSVSDDARMIAA . : : . .:. :. . ..:.. : ::::.. . .....:. . : . . CCDS77 AGGMEGPE---GLGRKQACLAMLLHFLDTYQGLLQEEEGAGHIIKDLYLLIMKDESLYQG 60 70 80 90 100 620 630 640 650 660 670 pF1KE1 LKEQLPELEKIVK----QISEDAKAPQKKHKVLLQQFNTGDERAQKRQPIRGSDEVLFKV :.:. .:...:. .: :. . :.:. : :...: : : : .:::::.. .: CCDS77 LREDTLRLHQLVETVELKIPEENQPPSKQVKPLFRHFRRIDSCLQTRVAFRGSDEIFCRV 110 120 130 140 150 160 680 690 700 710 720 pF1KE1 YCMDPTYTTIRVPVATSVKEVISAVADKL-------GSGEGLIIVKMSSGGEKVVLKPND : : .:.::: ...::......:..:: : ..::.: .::.::::.:.:.. CCDS77 YMPDHSYVTIRSRLSASVQDILGSVTEKLQYSEEPAGREDSLILVAVSSSGEKVLLQPTE 170 180 190 200 210 220 730 740 750 760 770 780 pF1KE1 VSVFMTLTINGRLFACPREQFDSLTPLPEQEGPTVGTVGTFELMSSKDLAYQMTIYDWEL :: .: ::..:::: :.....:.::::. . : . .. . .:.: ..: . ::: CCDS77 DCVFTALGINSHLFACTRDSYEALVPLPEEIQVSPGDT-EIHRVEPEDVANHLTAFHWEL 230 240 250 260 270 280 790 800 810 820 830 840 pF1KE1 FNCVHELELIYHTFGRHNFKKTTANLDLFLRRFNEIQFWVVTEICLCSQLSKRVQLLKKF : ::::::.. ..: . .. ::::.:.:.: .:. ::.::. :: .::.:::::: CCDS77 FRCVHELEFVDYVFHGERGRRETANLELLLQRCSEVTHWVATEVLLCEAPGKRAQLLKKF 290 300 310 320 330 340 850 860 870 880 890 900 pF1KE1 IKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPSKFKKFYAEFESLMDPSRNHR ::::: ::. ..: ::.:.::::.:.::::: :::::::.:::... .::.: :: :::. CCDS77 IKIAALCKQNQDLLSFYAVVMGLDNAAVSRLRLTWEKLPGKFKNLFRKFENLTDPCRNHK 350 360 370 380 390 400 910 920 930 940 950 960 pF1KE1 AYRLTVAKLEPPLIPFMPLLIKDMTFTHEGNKTFIDNLVNFEKMRMIANTARTVRYYRSQ .:: ...:..::.:::.::..::.:: :::.::..:.:::.::.. .:. .::.: :::. CCDS77 SYREVISKMKPPVIPFVPLILKDLTFLHEGSKTLVDGLVNIEKLHSVAEKVRTIRKYRSR 410 420 430 440 450 460 970 980 990 1000 1010 pF1KE1 PFNPDAAQANKNHQDVRSYVRQLNVIDNQRTLSQMSHRLEPRRP :. : .:. :: ....::::..::::: : ..:..:: CCDS77 PLCLDM-EASPNHLQTKAYVRQFQVIDNQNLLFELSYKLEANSQ 470 480 490 500 510 1011 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Mon Nov 7 00:35:22 2016 done: Mon Nov 7 00:35:23 2016 Total Scan time: 4.210 Total Display time: 0.340 Function used was FASTA [36.3.4 Apr, 2011]