FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE4520, 557 aa 1>>>pF1KE4520 557 - 557 aa - 557 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.6125+/-0.000586; mu= 17.3955+/- 0.036 mean_var=102.4619+/-20.704, 0's: 0 Z-trim(107.7): 378 B-trim: 594 in 1/53 Lambda= 0.126705 statistics sampled from 15271 (15717) to 15271 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.523), E-opt: 0.2 (0.184), width: 16 Scan time: 8.170 The best scores are: opt bits E(85289) NP_005088 (OMIM: 600512,604619) leucine-rich gliom ( 557) 3734 694.4 2.4e-199 NP_001295205 (OMIM: 600512,604619) leucine-rich gl ( 509) 2803 524.2 3.9e-148 NP_060646 (OMIM: 608301) leucine-rich repeat LGI f ( 545) 2125 400.3 8.2e-111 NP_644807 (OMIM: 608302) leucine-rich repeat LGI f ( 548) 2068 389.9 1.1e-107 XP_016872400 (OMIM: 600512,604619) PREDICTED: leuc ( 281) 1888 356.7 5.7e-98 NP_001295204 (OMIM: 600512,604619) leucine-rich gl ( 291) 1878 354.9 2.1e-97 NP_644813 (OMIM: 608303) leucine-rich repeat LGI f ( 537) 1774 336.1 1.7e-91 XP_016881919 (OMIM: 608303) PREDICTED: leucine-ric ( 365) 1098 212.4 2e-54 XP_016881917 (OMIM: 608303) PREDICTED: leucine-ric ( 365) 1098 212.4 2e-54 XP_016881918 (OMIM: 608303) PREDICTED: leucine-ric ( 365) 1098 212.4 2e-54 XP_011524897 (OMIM: 608303) PREDICTED: leucine-ric ( 365) 1098 212.4 2e-54 XP_011512152 (OMIM: 608301) PREDICTED: leucine-ric ( 331) 1012 196.6 1e-49 XP_016863845 (OMIM: 608301) PREDICTED: leucine-ric ( 287) 998 194.0 5.4e-49 XP_016872401 (OMIM: 600512,604619) PREDICTED: leuc ( 243) 947 184.6 3.1e-46 XP_011515759 (OMIM: 615904) PREDICTED: peroxidasin (1439) 341 74.6 2.4e-12 XP_011515758 (OMIM: 615904) PREDICTED: peroxidasin (1439) 322 71.1 2.7e-11 XP_005264764 (OMIM: 269400,605158) PREDICTED: pero (1455) 314 69.6 7.5e-11 XP_016865268 (OMIM: 603745) PREDICTED: slit homolo (1460) 310 68.9 1.2e-10 NP_003053 (OMIM: 603745) slit homolog 3 protein is (1523) 310 68.9 1.3e-10 NP_001258875 (OMIM: 603745) slit homolog 3 protein (1530) 310 68.9 1.3e-10 XP_011512212 (OMIM: 603746) PREDICTED: slit homolo (1159) 305 67.9 2e-10 XP_016864334 (OMIM: 603746) PREDICTED: slit homolo (1495) 305 68.0 2.4e-10 XP_011512211 (OMIM: 603746) PREDICTED: slit homolo (1499) 305 68.0 2.4e-10 XP_006714049 (OMIM: 603746) PREDICTED: slit homolo (1509) 305 68.0 2.4e-10 NP_001276065 (OMIM: 603746) slit homolog 2 protein (1521) 305 68.0 2.4e-10 NP_001276064 (OMIM: 603746) slit homolog 2 protein (1525) 305 68.0 2.4e-10 NP_004778 (OMIM: 603746) slit homolog 2 protein is (1529) 305 68.0 2.4e-10 XP_005248268 (OMIM: 603746) PREDICTED: slit homolo (1533) 305 68.0 2.4e-10 XP_016867994 (OMIM: 610486) PREDICTED: leucine-ric ( 653) 295 65.8 4.7e-10 NP_071426 (OMIM: 610486) leucine-rich repeat-conta ( 653) 295 65.8 4.7e-10 XP_011514763 (OMIM: 610486) PREDICTED: leucine-ric ( 653) 295 65.8 4.7e-10 XP_005271426 (OMIM: 608869,615112) PREDICTED: leuc ( 958) 296 66.2 5.4e-10 XP_016873559 (OMIM: 608817) PREDICTED: leucine-ric ( 640) 289 64.7 9.9e-10 XP_011518544 (OMIM: 608817) PREDICTED: leucine-ric ( 640) 289 64.7 9.9e-10 XP_016873563 (OMIM: 608817) PREDICTED: leucine-ric ( 640) 289 64.7 9.9e-10 XP_016873562 (OMIM: 608817) PREDICTED: leucine-ric ( 640) 289 64.7 9.9e-10 XP_016873560 (OMIM: 608817) PREDICTED: leucine-ric ( 640) 289 64.7 9.9e-10 XP_016873567 (OMIM: 608817) PREDICTED: leucine-ric ( 640) 289 64.7 9.9e-10 XP_016873561 (OMIM: 608817) PREDICTED: leucine-ric ( 640) 289 64.7 9.9e-10 XP_011518543 (OMIM: 608817) PREDICTED: leucine-ric ( 640) 289 64.7 9.9e-10 NP_065980 (OMIM: 608817) leucine-rich repeat-conta ( 640) 289 64.7 9.9e-10 XP_016873565 (OMIM: 608817) PREDICTED: leucine-ric ( 640) 289 64.7 9.9e-10 XP_016873564 (OMIM: 608817) PREDICTED: leucine-ric ( 640) 289 64.7 9.9e-10 XP_011518541 (OMIM: 608817) PREDICTED: leucine-ric ( 640) 289 64.7 9.9e-10 NP_001245348 (OMIM: 608817) leucine-rich repeat-co ( 640) 289 64.7 9.9e-10 XP_011518540 (OMIM: 608817) PREDICTED: leucine-ric ( 640) 289 64.7 9.9e-10 XP_011518542 (OMIM: 608817) PREDICTED: leucine-ric ( 640) 289 64.7 9.9e-10 XP_011518546 (OMIM: 608817) PREDICTED: leucine-ric ( 640) 289 64.7 9.9e-10 XP_011518545 (OMIM: 608817) PREDICTED: leucine-ric ( 640) 289 64.7 9.9e-10 XP_016873566 (OMIM: 608817) PREDICTED: leucine-ric ( 640) 289 64.7 9.9e-10 >>NP_005088 (OMIM: 600512,604619) leucine-rich glioma-in (557 aa) initn: 3734 init1: 3734 opt: 3734 Z-score: 3699.8 bits: 694.4 E(85289): 2.4e-199 Smith-Waterman score: 3734; 100.0% identity (100.0% similar) in 557 aa overlap (1-557:1-557) 10 20 30 40 50 60 pF1KE4 MESERSKRMGNACIPLKRIAYFLCLLSALLLTEGKKPAKPKCPAVCTCTKDNALCENARS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 MESERSKRMGNACIPLKRIAYFLCLLSALLLTEGKKPAKPKCPAVCTCTKDNALCENARS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 IPRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFDVISDDAFIGLPHLEYL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 IPRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFDVISDDAFIGLPHLEYL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 FIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKDIFKGLDSLTNVDLRGNSFNCDCK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 FIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKDIFKGLDSLTNVDLRGNSFNCDCK 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 LKWLVEWLGHTNATVEDIYCEGPPEYKKRKINSLSSKDFDCIITEFAKSQDLPYQSLSID :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 LKWLVEWLGHTNATVEDIYCEGPPEYKKRKINSLSSKDFDCIITEFAKSQDLPYQSLSID 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 TFSYLNDEYVVIAQPFTGKCIFLEWDHVEKTFRNYDNITGTSTVVCKPIVIETQLYVIVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 TFSYLNDEYVVIAQPFTGKCIFLEWDHVEKTFRNYDNITGTSTVVCKPIVIETQLYVIVA 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 QLFGGSHIYKRDSFANKFIKIQDIEILKIRKPNDIETFKIENNWYFVVADSSKAGFTTIY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 QLFGGSHIYKRDSFANKFIKIQDIEILKIRKPNDIETFKIENNWYFVVADSSKAGFTTIY 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE4 KWNGNGFYSHQSLHAWYRDTDVEYLEIVRTPQTLRTPHLILSSSSQRPVIYQWNKATQLF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 KWNGNGFYSHQSLHAWYRDTDVEYLEIVRTPQTLRTPHLILSSSSQRPVIYQWNKATQLF 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE4 TNQTDIPNMEDVYAVKHFSVKGDVYICLTRFIGDSKVMKWGGSSFQDIQRMPSRGSMVFQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 TNQTDIPNMEDVYAVKHFSVKGDVYICLTRFIGDSKVMKWGGSSFQDIQRMPSRGSMVFQ 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE4 PLQINNYQYAILGSDYSFTQVYNWDAEKAKFVKFQELNVQAPRSFTHVSINKRNFLFASS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 PLQINNYQYAILGSDYSFTQVYNWDAEKAKFVKFQELNVQAPRSFTHVSINKRNFLFASS 490 500 510 520 530 540 550 pF1KE4 FKGNTQIYKHVIVDLSA ::::::::::::::::: NP_005 FKGNTQIYKHVIVDLSA 550 >>NP_001295205 (OMIM: 600512,604619) leucine-rich glioma (509 aa) initn: 2802 init1: 2802 opt: 2803 Z-score: 2780.6 bits: 524.2 E(85289): 3.9e-148 Smith-Waterman score: 3319; 91.4% identity (91.4% similar) in 557 aa overlap (1-557:1-509) 10 20 30 40 50 60 pF1KE4 MESERSKRMGNACIPLKRIAYFLCLLSALLLTEGKKPAKPKCPAVCTCTKDNALCENARS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MESERSKRMGNACIPLKRIAYFLCLLSALLLTEGKKPAKPKCPAVCTCTKDNALCENARS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 IPRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFDVISDDAFIGLPHLEYL :::::::::::::::::::::::::::::::::::: NP_001 IPRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQLL------------------------ 70 80 90 130 140 150 160 170 180 pF1KE4 FIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKDIFKGLDSLTNVDLRGNSFNCDCK :::::::::::::::::::::::::::::::::::: NP_001 ------------------------SLANNNLQTLPKDIFKGLDSLTNVDLRGNSFNCDCK 100 110 120 130 190 200 210 220 230 240 pF1KE4 LKWLVEWLGHTNATVEDIYCEGPPEYKKRKINSLSSKDFDCIITEFAKSQDLPYQSLSID :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LKWLVEWLGHTNATVEDIYCEGPPEYKKRKINSLSSKDFDCIITEFAKSQDLPYQSLSID 140 150 160 170 180 190 250 260 270 280 290 300 pF1KE4 TFSYLNDEYVVIAQPFTGKCIFLEWDHVEKTFRNYDNITGTSTVVCKPIVIETQLYVIVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TFSYLNDEYVVIAQPFTGKCIFLEWDHVEKTFRNYDNITGTSTVVCKPIVIETQLYVIVA 200 210 220 230 240 250 310 320 330 340 350 360 pF1KE4 QLFGGSHIYKRDSFANKFIKIQDIEILKIRKPNDIETFKIENNWYFVVADSSKAGFTTIY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QLFGGSHIYKRDSFANKFIKIQDIEILKIRKPNDIETFKIENNWYFVVADSSKAGFTTIY 260 270 280 290 300 310 370 380 390 400 410 420 pF1KE4 KWNGNGFYSHQSLHAWYRDTDVEYLEIVRTPQTLRTPHLILSSSSQRPVIYQWNKATQLF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KWNGNGFYSHQSLHAWYRDTDVEYLEIVRTPQTLRTPHLILSSSSQRPVIYQWNKATQLF 320 330 340 350 360 370 430 440 450 460 470 480 pF1KE4 TNQTDIPNMEDVYAVKHFSVKGDVYICLTRFIGDSKVMKWGGSSFQDIQRMPSRGSMVFQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TNQTDIPNMEDVYAVKHFSVKGDVYICLTRFIGDSKVMKWGGSSFQDIQRMPSRGSMVFQ 380 390 400 410 420 430 490 500 510 520 530 540 pF1KE4 PLQINNYQYAILGSDYSFTQVYNWDAEKAKFVKFQELNVQAPRSFTHVSINKRNFLFASS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PLQINNYQYAILGSDYSFTQVYNWDAEKAKFVKFQELNVQAPRSFTHVSINKRNFLFASS 440 450 460 470 480 490 550 pF1KE4 FKGNTQIYKHVIVDLSA ::::::::::::::::: NP_001 FKGNTQIYKHVIVDLSA 500 >>NP_060646 (OMIM: 608301) leucine-rich repeat LGI famil (545 aa) initn: 2268 init1: 1484 opt: 2125 Z-score: 2110.4 bits: 400.3 E(85289): 8.2e-111 Smith-Waterman score: 2125; 55.9% identity (81.1% similar) in 540 aa overlap (19-556:11-544) 10 20 30 40 50 pF1KE4 MESERSKRMGNACIPLKRIAYFLCLLSALLLTEGKKPAK--PKCPAVCTCTKDNALCENA .. .: ::.: : . .. .:::.:.:::.. .: .. NP_060 MALRRGGCGALGLLLLLLGAACLIPRSAQVRRLARCPATCSCTKESIICVGS 10 20 30 40 50 60 70 80 90 100 110 pF1KE4 RSIPRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFDVISDDAFIGLPHLE .:: :: :. :::.: . :.::.. : :::::::..:::: .: :::: :: ::: NP_060 SWVPRIVPGDISSLSLVNGTFSEIKDRMFSHLPSLQLLLLNSNSFTIIRDDAFAGLFHLE 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE4 YLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKDIFKGLDSLTNVDLRGNSFNCD :::::.:.:..:::..::::..: :::::::....::.:.:. :::: ..:::::.:.:: NP_060 YLFIEGNKIETISRNAFRGLRDLTHLSLANNHIKALPRDVFSDLDSLIELDLRGNKFECD 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE4 CKLKWLVEWLGHTNATVEDIYCEGPPEYKKRKINSLSSKDFDCIITEFAKSQDLPYQSLS :: ::: :: ::.:: :. : :::::...:.:...: :..: :.:. : :::::.: NP_060 CKAKWLYLWLKMTNSTVSDVLCIGPPEYQEKKLNDVTSFDYECTTTDFVVHQTLPYQSVS 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE4 IDTFSYLNDEYVVIAQPFTGKCIFLEWDHVEKTFRNYDNITGTSTVVCKPIVIETQLYVI .:::. :: ::.:::: .:. :::::.: .::.:::::: : : :: :.:. :..:. NP_060 VDTFNSKNDVYVAIAQPSMENCMVLEWDHIEMNFRSYDNITGQSIVGCKAILIDDQVFVV 240 250 260 270 280 290 300 310 320 330 340 350 pF1KE4 VAQLFGGSHIYKRDSFANKFIKIQDIEILKIRKPNDIETFKIENNWYFVVADSSKAGFTT :::::::::::: : .::.:.::::. .: :::::: :.:... .::.:::::::..: NP_060 VAQLFGGSHIYKYDESWTKFVKFQDIEVSRISKPNDIELFQIDDETFFVIADSSKAGLST 300 310 320 330 340 350 360 370 380 390 400 410 pF1KE4 IYKWNGNGFYSHQSLHAWYRDTDVEYLEIVRTPQTLRTPHLILSSSSQRPVIYQWNKATQ .::::..::::.:::: :.::::.:...: :::::: :: :.: ::::... NP_060 VYKWNSKGFYSYQSLHEWFRDTDAEFVDIDG------KSHLILSSRSQVPIILQWNKSSK 360 370 380 390 400 420 430 440 450 460 470 pF1KE4 LFTNQTDIPNMEDVYAVKHFSVKGDVYICLTRFIGDSKVMKWGGSSFQDIQRMPSRGSMV :. . :::::::: ::: : ... .:. ::::::::.::.:....: .:: .::::.:. NP_060 KFVPHGDIPNMEDVLAVKSFRMQNTLYLSLTRFIGDSRVMRWNSKQFVEIQALPSRGAMT 410 420 430 440 450 460 480 490 500 510 520 530 pF1KE4 FQPLQINNYQYAILGSDYSFTQVYNWDAEKAKFVKFQELNVQAPRSFTHVSINKRNFLFA .::..... .: :::::.:.:.:.:: :: : ::.:. :::::::: :: ..:.:.:: NP_060 LQPFSFKDNHYLALGSDYTFSQIYQWDKEKQLFKKFKEIYVQAPRSFTAVSTDRRDFFFA 470 480 490 500 510 520 540 550 pF1KE4 SSFKGNTQIYKHVIVDLSA :::::.:.:..:.::::: NP_060 SSFKGKTKIFEHIIVDLSL 530 540 >>NP_644807 (OMIM: 608302) leucine-rich repeat LGI famil (548 aa) initn: 1503 init1: 1468 opt: 2068 Z-score: 2054.0 bits: 389.9 E(85289): 1.1e-107 Smith-Waterman score: 2068; 52.0% identity (81.5% similar) in 535 aa overlap (23-557:22-548) 10 20 30 40 50 60 pF1KE4 MESERSKRMGNACIPLKRIAYFLCLLSALLLTEGKKPAKPKCPAVCTCTKDNALCENARS .::. : .. . : : :: :.::.:.:.: .... NP_644 MAGLRARGGPGPGLLALSALGFCLM--LQVSAKRPPKTPPCPPSCSCTRDTAFCVDSKA 10 20 30 40 50 70 80 90 100 110 120 pF1KE4 IPRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFDVISDDAFIGLPHLEYL .::..: .::::..: ..:.::..:.: : ::.::..::.: .:.:.:: :: ::.:: NP_644 VPRNLPSEVISLTLVNAAFSEIQDGAFSHLPLLQFLLLNSNKFTLIGDNAFTGLSHLQYL 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE4 FIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKDIFKGLDSLTNVDLRGNSFNCDCK :::::.: ..:. :::::::: :::::::::::::.:::. :: :...::::::.::::: NP_644 FIENNDIWALSKFTFRGLKSLTHLSLANNNLQTLPRDIFRPLDILNDLDLRGNSLNCDCK 120 130 140 150 160 170 190 200 210 220 230 240 pF1KE4 LKWLVEWLGHTNATVEDIYCEGPPEYKKRKINSLSSKDFDCIITEFAKSQDLPYQSLSID .:::::::.:::.:: ::: .::.....:...: ..:::: :.:. : : . ..: . NP_644 VKWLVEWLAHTNTTVAPIYCASPPRFQEHKVQDLPLREFDCITTDFVLYQTLAFPAVSAE 180 190 200 210 220 230 250 260 270 280 290 300 pF1KE4 TFSYLNDEYVVIAQPFTGKCIFLEWDHVEKTFRNYDNITGTSTVVCKPIVIETQLYVIVA : : .: :...::: .. : .:.::.::. .:.:: : . :.: :::.:...::::.:: NP_644 PFLYSSDLYLALAQPGVSACTILKWDYVERQLRDYDRIPAPSAVHCKPMVVDSQLYVVVA 240 250 260 270 280 290 310 320 330 340 350 360 pF1KE4 QLFGGSHIYKRDSFANKFIKIQDIEILKIRKPNDIETFKIENNWYFVVADSSKAGFTTIY ::::::.::. : ...: ..:::. ..:::::.:.:.:...:::.:::::::: :..: NP_644 QLFGGSYIYHWDPNTTRFTRLQDIDPQRVRKPNDLEAFRIDGDWYFAVADSSKAGATSLY 300 310 320 330 340 350 370 380 390 400 410 420 pF1KE4 KWNGNGFYSHQSLHAWYRDTDVEYLEIVRTPQTLRTPHLILSSSSQRPVIYQWNKATQLF .:. :::::::.:: :.::::.:... :.::.::::: ::::::... . : NP_644 RWHQNGFYSHQALHPWHRDTDLEFVD------GEGKPRLIVSSSSQAPVIYQWSRTQKQF 360 370 380 390 400 410 430 440 450 460 470 480 pF1KE4 TNQTDIPNMEDVYAVKHFSVKGDVYICLTRFIGDSKVMKWGGSSFQDIQRMPSRGSMVFQ . : .. .. :. ::::: . : :.::.:.:::::...: :. :...: .:::::...: NP_644 VAQGEVTQVPDAQAVKHFRAGRDSYLCLSRYIGDSKILRWEGTRFSEVQALPSRGSLALQ 420 430 440 450 460 470 490 500 510 520 530 540 pF1KE4 PLQINNYQYAILGSDYSFTQVYNWDAEKAKFVKFQELNVQAPRSFTHVSINKRNFLFASS :. ... .: ::::.::::.:.:: . :::.:::: :::::.: .. . ..:.: : NP_644 PFLVGGRRYLALGSDFSFTQIYQWDEGRQKFVRFQELAVQAPRAFCYMPAGDAQLLLAPS 480 490 500 510 520 530 550 pF1KE4 FKGNTQIYKHVIVDLSA :::.: .:.:..::::: NP_644 FKGQTLVYRHIVVDLSA 540 >>XP_016872400 (OMIM: 600512,604619) PREDICTED: leucine- (281 aa) initn: 1977 init1: 1888 opt: 1888 Z-score: 1879.9 bits: 356.7 E(85289): 5.7e-98 Smith-Waterman score: 1888; 99.6% identity (100.0% similar) in 281 aa overlap (1-281:1-281) 10 20 30 40 50 60 pF1KE4 MESERSKRMGNACIPLKRIAYFLCLLSALLLTEGKKPAKPKCPAVCTCTKDNALCENARS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MESERSKRMGNACIPLKRIAYFLCLLSALLLTEGKKPAKPKCPAVCTCTKDNALCENARS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 IPRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFDVISDDAFIGLPHLEYL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IPRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFDVISDDAFIGLPHLEYL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 FIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKDIFKGLDSLTNVDLRGNSFNCDCK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKDIFKGLDSLTNVDLRGNSFNCDCK 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 LKWLVEWLGHTNATVEDIYCEGPPEYKKRKINSLSSKDFDCIITEFAKSQDLPYQSLSID :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LKWLVEWLGHTNATVEDIYCEGPPEYKKRKINSLSSKDFDCIITEFAKSQDLPYQSLSID 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 TFSYLNDEYVVIAQPFTGKCIFLEWDHVEKTFRNYDNITGTSTVVCKPIVIETQLYVIVA ::::::::::::::::::::::::::::::::::::::::. XP_016 TFSYLNDEYVVIAQPFTGKCIFLEWDHVEKTFRNYDNITGS 250 260 270 280 310 320 330 340 350 360 pF1KE4 QLFGGSHIYKRDSFANKFIKIQDIEILKIRKPNDIETFKIENNWYFVVADSSKAGFTTIY >>NP_001295204 (OMIM: 600512,604619) leucine-rich glioma (291 aa) initn: 1878 init1: 1878 opt: 1878 Z-score: 1869.8 bits: 354.9 E(85289): 2.1e-97 Smith-Waterman score: 1878; 100.0% identity (100.0% similar) in 279 aa overlap (1-279:1-279) 10 20 30 40 50 60 pF1KE4 MESERSKRMGNACIPLKRIAYFLCLLSALLLTEGKKPAKPKCPAVCTCTKDNALCENARS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MESERSKRMGNACIPLKRIAYFLCLLSALLLTEGKKPAKPKCPAVCTCTKDNALCENARS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 IPRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFDVISDDAFIGLPHLEYL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IPRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFDVISDDAFIGLPHLEYL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 FIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKDIFKGLDSLTNVDLRGNSFNCDCK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKDIFKGLDSLTNVDLRGNSFNCDCK 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 LKWLVEWLGHTNATVEDIYCEGPPEYKKRKINSLSSKDFDCIITEFAKSQDLPYQSLSID :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LKWLVEWLGHTNATVEDIYCEGPPEYKKRKINSLSSKDFDCIITEFAKSQDLPYQSLSID 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 TFSYLNDEYVVIAQPFTGKCIFLEWDHVEKTFRNYDNITGTSTVVCKPIVIETQLYVIVA ::::::::::::::::::::::::::::::::::::::: NP_001 TFSYLNDEYVVIAQPFTGKCIFLEWDHVEKTFRNYDNITVLREIHRFTNMS 250 260 270 280 290 310 320 330 340 350 360 pF1KE4 QLFGGSHIYKRDSFANKFIKIQDIEILKIRKPNDIETFKIENNWYFVVADSSKAGFTTIY >>NP_644813 (OMIM: 608303) leucine-rich repeat LGI famil (537 aa) initn: 1909 init1: 1208 opt: 1774 Z-score: 1763.7 bits: 336.1 E(85289): 1.7e-91 Smith-Waterman score: 1774; 48.6% identity (75.7% similar) in 539 aa overlap (22-557:7-537) 10 20 30 40 50 60 pF1KE4 MESERSKRMGNACIPLKRIAYFLCLLSALLLTEGKKPAKPKCPAVCTCTKDNALCENARS .: ::.. .. . .: : ::: :.:.::.::::.. . NP_644 MGGAGILLLLLAGAGVVVAWRPPKGKCPLRCSCSKDSALCEGSPD 10 20 30 40 70 80 90 100 110 120 pF1KE4 IPRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFDVISDDAFIGLPHLEYL .: . : ..:::.::.: :... :::: :::.:::::::::.:: :::: :: ::.:: NP_644 LPVSFSPTLLSLSLVRTGVTQLKAGSFLRIPSLHLLLFTSNSFSVIEDDAFAGLSHLQYL 50 60 70 80 90 100 130 140 150 160 170 180 pF1KE4 FIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKDIFKGLDSLTNVDLRGNSFNCDCK :::.:.: :::....:::.:: :::::::.:.:::. .:.:::.::.:::::: :.:::. NP_644 FIEDNEIGSISKNALRGLRSLTHLSLANNHLETLPRFLFRGLDTLTHVDLRGNPFQCDCR 110 120 130 140 150 160 190 200 210 220 230 240 pF1KE4 LKWLVEWLGHTNATVEDIYCEGPPEYKKRKINSLSSKDFDCIITEFAKSQDLPYQSLSID . ::..:. .::.: : :: .. ... :. : : : :.. : . ..::.. NP_644 VLWLLQWMPTVNASVGTGACAGPASLSHMQLHHLDPKTFKCRAIELSWFQTVGESALSVE 170 180 190 200 210 220 250 260 270 280 290 300 pF1KE4 TFSYLNDEYVVIAQPFTGKCIFLEWDHVEKTFRNYDNITGTSTVVCKPIVIETQLYVIVA ::: .. ..:.::::.:.:..: ::. . :: ... ..:.: :::.:. .:.:..: NP_644 PFSYQGEPHIVLAQPFAGRCLILSWDYSLQRFRPEEELPAASVVSCKPLVLGPSLFVLAA 230 240 250 260 270 280 310 320 330 340 350 360 pF1KE4 QLFGGSHIYKRDSFANKFIKIQDIEILKIRKPNDIETFKIENNWYFVVADSSKAGFTTIY .:.:::... : : . .. : . .. .::: : . .:.. :::::.:::: ::. NP_644 RLWGGSQLWARPSPGLRLAPTQTLAPRRLLRPNDAELLWLEGQPCFVVADASKAGSTTLL 290 300 310 320 330 340 370 380 390 400 410 420 pF1KE4 KWNGNGFYSHQSLHAWYRDTDVEYLEIVRTPQTLRTPHLILSSSSQRPVIYQWNKATQLF .: ::: :::::::.::::.: ::. : ::.:.:.:::::...:. . : NP_644 CRDGPGFYPHQSLHAWHRDTDAEALELDGRP------HLLLASASQRPVLFHWTGGR--F 350 360 370 380 390 430 440 450 460 470 480 pF1KE4 TNQTDIPNMEDVYAVKHFSVKGDVYICLTRFIGDSKVMKWGGSSFQDIQRMPSRGSMVFQ .::::. :::::..::.. :::..::::.:::: ::.: :: :. .:..::::. ::: NP_644 ERRTDIPEAEDVYATRHFQAGGDVFLCLTRYIGDSMVMRWDGSMFRLLQQLPSRGAHVFQ 400 410 420 430 440 450 490 500 510 520 530 pF1KE4 PLQINNYQYAILGSDYSFTQVYNWDAEKAKFVKFQELN---VQAPRSFTHVSINKRNFLF :: : : ::::::..:.:: . .:. . .:::. . :::.:.:... : ::: NP_644 PLLIARDQLAILGSDFAFSQVLRLEPDKGLLEPLQELGPPALVAPRAFAHITMAGRRFLF 460 470 480 490 500 510 540 550 pF1KE4 ASSFKGNTQIYKHVIVDLSA :. ::: ::::.: .:::: NP_644 AACFKGPTQIYQHHEIDLSA 520 530 >>XP_016881919 (OMIM: 608303) PREDICTED: leucine-rich re (365 aa) initn: 1115 init1: 536 opt: 1098 Z-score: 1098.0 bits: 212.4 E(85289): 2e-54 Smith-Waterman score: 1098; 45.0% identity (72.1% similar) in 369 aa overlap (192-557:5-365) 170 180 190 200 210 220 pF1KE4 LDSLTNVDLRGNSFNCDCKLKWLVEWLGHTNATVEDIYCEGPPEYKKRKINSLSSKDFDC ::.: : :: .. ... :. : : : XP_016 MPTVNASVGTGACAGPASLSHMQLHHLDPKTFKC 10 20 30 230 240 250 260 270 280 pF1KE4 IITEFAKSQDLPYQSLSIDTFSYLNDEYVVIAQPFTGKCIFLEWDHVEKTFRNYDNITGT :.. : . ..::.. ::: .. ..:.::::.:.:..: ::. . :: ... .. XP_016 RAIELSWFQTVGESALSVEPFSYQGEPHIVLAQPFAGRCLILSWDYSLQRFRPEEELPAA 40 50 60 70 80 90 290 300 310 320 330 340 pF1KE4 STVVCKPIVIETQLYVIVAQLFGGSHIYKRDSFANKFIKIQDIEILKIRKPNDIETFKIE :.: :::.:. .:.:..:.:.:::... : : . .. : . .. .::: : . .: XP_016 SVVSCKPLVLGPSLFVLAARLWGGSQLWARPSPGLRLAPTQTLAPRRLLRPNDAELLWLE 100 110 120 130 140 150 350 360 370 380 390 400 pF1KE4 NNWYFVVADSSKAGFTTIYKWNGNGFYSHQSLHAWYRDTDVEYLEIVRTPQTLRTPHLIL .. :::::.:::: ::. .: ::: :::::::.::::.: ::. :::.: XP_016 GQPCFVVADASKAGSTTLLCRDGPGFYPHQSLHAWHRDTDAEALELDGR------PHLLL 160 170 180 190 200 410 420 430 440 450 460 pF1KE4 SSSSQRPVIYQWNKATQLFTNQTDIPNMEDVYAVKHFSVKGDVYICLTRFIGDSKVMKWG .:.:::::...:. . : .::::. :::::..::.. :::..::::.:::: ::.: XP_016 ASASQRPVLFHWTGGR--FERRTDIPEAEDVYATRHFQAGGDVFLCLTRYIGDSMVMRWD 210 220 230 240 250 260 470 480 490 500 510 pF1KE4 GSSFQDIQRMPSRGSMVFQPLQINNYQYAILGSDYSFTQVYNWDAEKAKFVKFQELN--- :: :. .:..::::. ::::: : : ::::::..:.:: . .:. . .:::. XP_016 GSMFRLLQQLPSRGAHVFQPLLIARDQLAILGSDFAFSQVLRLEPDKGLLEPLQELGPPA 270 280 290 300 310 320 520 530 540 550 pF1KE4 VQAPRSFTHVSINKRNFLFASSFKGNTQIYKHVIVDLSA . :::.:.:... : ::::. ::: ::::.: .:::: XP_016 LVAPRAFAHITMAGRRFLFAACFKGPTQIYQHHEIDLSA 330 340 350 360 >>XP_016881917 (OMIM: 608303) PREDICTED: leucine-rich re (365 aa) initn: 1115 init1: 536 opt: 1098 Z-score: 1098.0 bits: 212.4 E(85289): 2e-54 Smith-Waterman score: 1098; 45.0% identity (72.1% similar) in 369 aa overlap (192-557:5-365) 170 180 190 200 210 220 pF1KE4 LDSLTNVDLRGNSFNCDCKLKWLVEWLGHTNATVEDIYCEGPPEYKKRKINSLSSKDFDC ::.: : :: .. ... :. : : : XP_016 MPTVNASVGTGACAGPASLSHMQLHHLDPKTFKC 10 20 30 230 240 250 260 270 280 pF1KE4 IITEFAKSQDLPYQSLSIDTFSYLNDEYVVIAQPFTGKCIFLEWDHVEKTFRNYDNITGT :.. : . ..::.. ::: .. ..:.::::.:.:..: ::. . :: ... .. XP_016 RAIELSWFQTVGESALSVEPFSYQGEPHIVLAQPFAGRCLILSWDYSLQRFRPEEELPAA 40 50 60 70 80 90 290 300 310 320 330 340 pF1KE4 STVVCKPIVIETQLYVIVAQLFGGSHIYKRDSFANKFIKIQDIEILKIRKPNDIETFKIE :.: :::.:. .:.:..:.:.:::... : : . .. : . .. .::: : . .: XP_016 SVVSCKPLVLGPSLFVLAARLWGGSQLWARPSPGLRLAPTQTLAPRRLLRPNDAELLWLE 100 110 120 130 140 150 350 360 370 380 390 400 pF1KE4 NNWYFVVADSSKAGFTTIYKWNGNGFYSHQSLHAWYRDTDVEYLEIVRTPQTLRTPHLIL .. :::::.:::: ::. .: ::: :::::::.::::.: ::. :::.: XP_016 GQPCFVVADASKAGSTTLLCRDGPGFYPHQSLHAWHRDTDAEALELDGR------PHLLL 160 170 180 190 200 410 420 430 440 450 460 pF1KE4 SSSSQRPVIYQWNKATQLFTNQTDIPNMEDVYAVKHFSVKGDVYICLTRFIGDSKVMKWG .:.:::::...:. . : .::::. :::::..::.. :::..::::.:::: ::.: XP_016 ASASQRPVLFHWTGGR--FERRTDIPEAEDVYATRHFQAGGDVFLCLTRYIGDSMVMRWD 210 220 230 240 250 260 470 480 490 500 510 pF1KE4 GSSFQDIQRMPSRGSMVFQPLQINNYQYAILGSDYSFTQVYNWDAEKAKFVKFQELN--- :: :. .:..::::. ::::: : : ::::::..:.:: . .:. . .:::. XP_016 GSMFRLLQQLPSRGAHVFQPLLIARDQLAILGSDFAFSQVLRLEPDKGLLEPLQELGPPA 270 280 290 300 310 320 520 530 540 550 pF1KE4 VQAPRSFTHVSINKRNFLFASSFKGNTQIYKHVIVDLSA . :::.:.:... : ::::. ::: ::::.: .:::: XP_016 LVAPRAFAHITMAGRRFLFAACFKGPTQIYQHHEIDLSA 330 340 350 360 >>XP_016881918 (OMIM: 608303) PREDICTED: leucine-rich re (365 aa) initn: 1115 init1: 536 opt: 1098 Z-score: 1098.0 bits: 212.4 E(85289): 2e-54 Smith-Waterman score: 1098; 45.0% identity (72.1% similar) in 369 aa overlap (192-557:5-365) 170 180 190 200 210 220 pF1KE4 LDSLTNVDLRGNSFNCDCKLKWLVEWLGHTNATVEDIYCEGPPEYKKRKINSLSSKDFDC ::.: : :: .. ... :. : : : XP_016 MPTVNASVGTGACAGPASLSHMQLHHLDPKTFKC 10 20 30 230 240 250 260 270 280 pF1KE4 IITEFAKSQDLPYQSLSIDTFSYLNDEYVVIAQPFTGKCIFLEWDHVEKTFRNYDNITGT :.. : . ..::.. ::: .. ..:.::::.:.:..: ::. . :: ... .. XP_016 RAIELSWFQTVGESALSVEPFSYQGEPHIVLAQPFAGRCLILSWDYSLQRFRPEEELPAA 40 50 60 70 80 90 290 300 310 320 330 340 pF1KE4 STVVCKPIVIETQLYVIVAQLFGGSHIYKRDSFANKFIKIQDIEILKIRKPNDIETFKIE :.: :::.:. .:.:..:.:.:::... : : . .. : . .. .::: : . .: XP_016 SVVSCKPLVLGPSLFVLAARLWGGSQLWARPSPGLRLAPTQTLAPRRLLRPNDAELLWLE 100 110 120 130 140 150 350 360 370 380 390 400 pF1KE4 NNWYFVVADSSKAGFTTIYKWNGNGFYSHQSLHAWYRDTDVEYLEIVRTPQTLRTPHLIL .. :::::.:::: ::. .: ::: :::::::.::::.: ::. :::.: XP_016 GQPCFVVADASKAGSTTLLCRDGPGFYPHQSLHAWHRDTDAEALELDGR------PHLLL 160 170 180 190 200 410 420 430 440 450 460 pF1KE4 SSSSQRPVIYQWNKATQLFTNQTDIPNMEDVYAVKHFSVKGDVYICLTRFIGDSKVMKWG .:.:::::...:. . : .::::. :::::..::.. :::..::::.:::: ::.: XP_016 ASASQRPVLFHWTGGR--FERRTDIPEAEDVYATRHFQAGGDVFLCLTRYIGDSMVMRWD 210 220 230 240 250 260 470 480 490 500 510 pF1KE4 GSSFQDIQRMPSRGSMVFQPLQINNYQYAILGSDYSFTQVYNWDAEKAKFVKFQELN--- :: :. .:..::::. ::::: : : ::::::..:.:: . .:. . .:::. XP_016 GSMFRLLQQLPSRGAHVFQPLLIARDQLAILGSDFAFSQVLRLEPDKGLLEPLQELGPPA 270 280 290 300 310 320 520 530 540 550 pF1KE4 VQAPRSFTHVSINKRNFLFASSFKGNTQIYKHVIVDLSA . :::.:.:... : ::::. ::: ::::.: .:::: XP_016 LVAPRAFAHITMAGRRFLFAACFKGPTQIYQHHEIDLSA 330 340 350 360 557 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 00:17:25 2016 done: Sun Nov 6 00:17:27 2016 Total Scan time: 8.170 Total Display time: 0.060 Function used was FASTA [36.3.4 Apr, 2011]