FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE9661, 255 aa 1>>>pF1KE9661 255 - 255 aa - 255 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.8488+/-0.000847; mu= 12.2662+/- 0.051 mean_var=75.6679+/-15.037, 0's: 0 Z-trim(107.1): 24 B-trim: 0 in 0/49 Lambda= 0.147441 statistics sampled from 9360 (9383) to 9360 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.67), E-opt: 0.2 (0.288), width: 16 Scan time: 2.260 The best scores are: opt bits E(32554) CCDS43056.1 METTL6 gene_id:131965|Hs108|chr3 ( 284) 1719 374.8 3.6e-104 CCDS77706.1 METTL6 gene_id:131965|Hs108|chr3 ( 239) 906 201.8 3.5e-52 CCDS5803.2 METTL2B gene_id:55798|Hs108|chr7 ( 378) 560 128.3 7.4e-30 CCDS45752.1 METTL2A gene_id:339175|Hs108|chr17 ( 378) 555 127.2 1.6e-29 CCDS2242.2 METTL8 gene_id:79828|Hs108|chr2 ( 407) 504 116.4 3.1e-26 CCDS82531.1 METTL8 gene_id:79828|Hs108|chr2 ( 241) 259 64.2 9.5e-11 >>CCDS43056.1 METTL6 gene_id:131965|Hs108|chr3 (284 aa) initn: 1719 init1: 1719 opt: 1719 Z-score: 1983.8 bits: 374.8 E(32554): 3.6e-104 Smith-Waterman score: 1719; 100.0% identity (100.0% similar) in 255 aa overlap (1-255:1-255) 10 20 30 40 50 60 pF1KE9 MASLQRKGLQARILTSEEEEKLKRDQTLVSDFKQQKLEQEAQKNWDLFYKRNSTNFFKDR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS43 MASLQRKGLQARILTSEEEEKLKRDQTLVSDFKQQKLEQEAQKNWDLFYKRNSTNFFKDR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE9 HWTTREFEELRSCREFEDQKLTMLEAGCGVGNCLFPLLEEDPNIFAYACDFSPRAIEYVK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS43 HWTTREFEELRSCREFEDQKLTMLEAGCGVGNCLFPLLEEDPNIFAYACDFSPRAIEYVK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE9 QNPLYDTERCKVFQCDLTKDDLLDHVPPESVDVVMLIFVLSAVHPDKMHLVLQNIYKVLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS43 QNPLYDTERCKVFQCDLTKDDLLDHVPPESVDVVMLIFVLSAVHPDKMHLVLQNIYKVLK 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE9 PGKSVLFRDYGLYDHAMLRFKASSKLGENFYVRQDGTRSYFFTDDFLAQLFMDTGYEEVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS43 PGKSVLFRDYGLYDHAMLRFKASSKLGENFYVRQDGTRSYFFTDDFLAQLFMDTGYEEVV 190 200 210 220 230 240 250 pF1KE9 NEYVFRETVNKKEGL ::::::::::::::: CCDS43 NEYVFRETVNKKEGLCVPRVFLQSKFLKPPKNPSPVVLGLDPKS 250 260 270 280 >>CCDS77706.1 METTL6 gene_id:131965|Hs108|chr3 (239 aa) initn: 906 init1: 906 opt: 906 Z-score: 1050.3 bits: 201.8 E(32554): 3.5e-52 Smith-Waterman score: 1302; 82.4% identity (82.4% similar) in 255 aa overlap (1-255:1-210) 10 20 30 40 50 60 pF1KE9 MASLQRKGLQARILTSEEEEKLKRDQTLVSDFKQQKLEQEAQKNWDLFYKRNSTNFFKDR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS77 MASLQRKGLQARILTSEEEEKLKRDQTLVSDFKQQKLEQEAQKNWDLFYKRNSTNFFKDR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE9 HWTTREFEELRSCREFEDQKLTMLEAGCGVGNCLFPLLEEDPNIFAYACDFSPRAIEYVK ::::::::::::::: CCDS77 HWTTREFEELRSCRE--------------------------------------------- 70 130 140 150 160 170 180 pF1KE9 QNPLYDTERCKVFQCDLTKDDLLDHVPPESVDVVMLIFVLSAVHPDKMHLVLQNIYKVLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS77 QNPLYDTERCKVFQCDLTKDDLLDHVPPESVDVVMLIFVLSAVHPDKMHLVLQNIYKVLK 80 90 100 110 120 130 190 200 210 220 230 240 pF1KE9 PGKSVLFRDYGLYDHAMLRFKASSKLGENFYVRQDGTRSYFFTDDFLAQLFMDTGYEEVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS77 PGKSVLFRDYGLYDHAMLRFKASSKLGENFYVRQDGTRSYFFTDDFLAQLFMDTGYEEVV 140 150 160 170 180 190 250 pF1KE9 NEYVFRETVNKKEGL ::::::::::::::: CCDS77 NEYVFRETVNKKEGLCVPRVFLQSKFLKPPKNPSPVVLGLDPKS 200 210 220 230 >>CCDS5803.2 METTL2B gene_id:55798|Hs108|chr7 (378 aa) initn: 670 init1: 475 opt: 560 Z-score: 649.5 bits: 128.3 E(32554): 7.4e-30 Smith-Waterman score: 560; 48.2% identity (69.5% similar) in 197 aa overlap (64-255:162-358) 40 50 60 70 80 90 pF1KE9 QQKLEQEAQKNWDLFYKRNSTNFFKDRHWTTREFEELRSCR-EFEDQKLT--MLEAGCGV :... .:. : :: .. : .::.:::: CCDS58 GPGLIMEEQHKCSSKSLEHKTQTPPVEENVTQKISDLEICADEFPGSSATYRILEVGCGV 140 150 160 170 180 190 100 110 120 130 140 pF1KE9 GNCLFPLLE--EDPNIFAYACDFSPRAIEYVKQNPLYDTERCKVFQCDLTKDDLLDHVPP :: .::.:. .::..:.: :::: ::: :. : :: :: .: :: .. :: CCDS58 GNTVFPILQTNNDPGLFVYCCDFSSTAIELVQTNSEYDPSRCFAFVHDLCDEEKSYPVPK 200 210 220 230 240 250 150 160 170 180 190 200 pF1KE9 ESVDVVMLIFVLSAVHPDKMHLVLQNIYKVLKPGKSVLFRDYGLYDHAMLRFKASSKLGE :.:...:::::::: ::::. ... . ..:::: ::.:::: :: :.:::: .. :. CCDS58 GSLDIIILIFVLSAVVPDKMQKAINRLSRLLKPGGMVLLRDYGRYDMAQLRFKKGQCLSG 260 270 280 290 300 310 210 220 230 240 250 pF1KE9 NFYVRQDGTRSYFFTDDFLAQLFMDTGYEEVVNEYVFRETVNKKEGL ::::: :::: ::::.. : :: .: :.: : : ::. . : CCDS58 NFYVRGDGTRVYFFTQEELDTLFTTAGLEKVQNLVDRRLQVNRGKQLTMYRVWIQCKYCK 320 330 340 350 360 370 CCDS58 PLLSSTS >>CCDS45752.1 METTL2A gene_id:339175|Hs108|chr17 (378 aa) initn: 665 init1: 470 opt: 555 Z-score: 643.7 bits: 127.2 E(32554): 1.6e-29 Smith-Waterman score: 555; 47.2% identity (69.5% similar) in 197 aa overlap (64-255:162-358) 40 50 60 70 80 90 pF1KE9 QQKLEQEAQKNWDLFYKRNSTNFFKDRHWTTREFEELRSCR-EFEDQKLT--MLEAGCGV :... .:. : :: .. : .::.:::: CCDS45 GPGLIMEEQHKCSSKSLEHKTQTLPVEENVTQKISDLEICADEFPGSSATYRILEVGCGV 140 150 160 170 180 190 100 110 120 130 140 pF1KE9 GNCLFPLLE--EDPNIFAYACDFSPRAIEYVKQNPLYDTERCKVFQCDLTKDDLLDHVPP :: .::.:. .::..:.: :::: ::: :. : :: :: .: :: .. :: CCDS45 GNTVFPILQTNNDPGLFVYCCDFSSTAIELVQTNSEYDPSRCFAFVHDLCDEEKSYPVPK 200 210 220 230 240 250 150 160 170 180 190 200 pF1KE9 ESVDVVMLIFVLSAVHPDKMHLVLQNIYKVLKPGKSVLFRDYGLYDHAMLRFKASSKLGE :.:...:::::::. ::::. ... . ..:::: .:.:::: :: :.:::: .. :. CCDS45 GSLDIIILIFVLSAIVPDKMQKAINRLSRLLKPGGMMLLRDYGRYDMAQLRFKKGQCLSG 260 270 280 290 300 310 210 220 230 240 250 pF1KE9 NFYVRQDGTRSYFFTDDFLAQLFMDTGYEEVVNEYVFRETVNKKEGL ::::: :::: ::::.. : :: .: :.: : : ::. . : CCDS45 NFYVRGDGTRVYFFTQEELDTLFTTAGLEKVQNLVDRRLQVNRGKQLTMYRVWIQCKYCK 320 330 340 350 360 370 CCDS45 PLLSSTS >>CCDS2242.2 METTL8 gene_id:79828|Hs108|chr2 (407 aa) initn: 630 init1: 443 opt: 504 Z-score: 584.6 bits: 116.4 E(32554): 3.1e-26 Smith-Waterman score: 504; 45.4% identity (70.1% similar) in 174 aa overlap (83-253:200-373) 60 70 80 90 100 pF1KE9 STNFFKDRHWTTREFEELRSCREFEDQKLTMLEAGCGVGNCLFPLL---EEDPNIFAYAC .::.:::.:: .::.: :..:. : : : CCDS22 ESDFSNLDSEKHKKGPMETGLFPGSNATFRILEVGCGAGNSVFPILNTLENSPESFLYCC 170 180 190 200 210 220 110 120 130 140 150 160 pF1KE9 DFSPRAIEYVKQNPLYDTERCKVFQCDLTKDDLLDHVPPESVDVVMLIFVLSAVHPDKMH ::. :.: ::.. : . .: .: :. : : : .::..:.::::..:::.:. CCDS22 DFASGAVELVKSHSSYRATQCFAFVHDVCDDGLPYPFPDGILDVILLVFVLSSIHPDRMQ 230 240 250 260 270 280 170 180 190 200 210 220 pF1KE9 LVLQNIYKVLKPGKSVLFRDYGLYDHAMLRFKASSKLGENFYVRQDGTRSYFFTDDFLAQ :.. . :.:::: .:::::: ::...:::: . :.:::::: ::::.:::: . . CCDS22 GVVNRLSKLLKPGGMLLFRDYGRYDKTQLRFKKGHCLSENFYVRGDGTRAYFFTKGEVHS 290 300 310 320 330 340 230 240 250 pF1KE9 LFMDTGYEEVVNEYVFRETVNKKEGL .: .. .: : : ::.:. CCDS22 MFCKASLDEKQNLVDRRLQVNRKKQVKMHRVWIQGKFQKPLHQTQNSSNMVSTLLSQD 350 360 370 380 390 400 >>CCDS82531.1 METTL8 gene_id:79828|Hs108|chr2 (241 aa) initn: 385 init1: 198 opt: 259 Z-score: 306.5 bits: 64.2 E(32554): 9.5e-11 Smith-Waterman score: 259; 41.3% identity (68.5% similar) in 92 aa overlap (83-171:150-241) 60 70 80 90 100 pF1KE9 STNFFKDRHWTTREFEELRSCREFEDQKLTMLEAGCGVGNCLFPLL---EEDPNIFAYAC .::.:::.:: .::.: :..:. : : : CCDS82 ESDFSNLDSEKHKKGPMETGLFPGSNATFRILEVGCGAGNSVFPILNTLENSPESFLYCC 120 130 140 150 160 170 110 120 130 140 150 160 pF1KE9 DFSPRAIEYVKQNPLYDTERCKVFQCDLTKDDLLDHVPPESVDVVMLIFVLSAVHPDKMH ::. :.: ::.. : . .: .: :. : : : .::..:.::::..:::. CCDS82 DFASGAVELVKSHSSYRATQCFAFVHDVCDDGLPYPFPDGILDVILLVFVLSSIHPDRTL 180 190 200 210 220 230 170 180 190 200 210 220 pF1KE9 LVLQNIYKVLKPGKSVLFRDYGLYDHAMLRFKASSKLGENFYVRQDGTRSYFFTDDFLAQ .. CCDS82 FI 240 255 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Mon Nov 7 17:45:12 2016 done: Mon Nov 7 17:45:12 2016 Total Scan time: 2.260 Total Display time: -0.020 Function used was FASTA [36.3.4 Apr, 2011]