FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE5508, 437 aa 1>>>pF1KE5508 437 - 437 aa - 437 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.4681+/-0.000371; mu= 17.7440+/- 0.023 mean_var=87.1013+/-17.452, 0's: 0 Z-trim(115.2): 49 B-trim: 467 in 1/51 Lambda= 0.137424 statistics sampled from 25479 (25527) to 25479 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.685), E-opt: 0.2 (0.299), width: 16 Scan time: 8.530 The best scores are: opt bits E(85289) NP_005693 (OMIM: 607435) GTPase Era, mitochondrial ( 437) 2918 588.5 1.1e-167 NP_001304914 (OMIM: 607435) GTPase Era, mitochondr ( 436) 2901 585.2 1.1e-166 NP_001304915 (OMIM: 607435) GTPase Era, mitochondr ( 354) 1580 323.2 6.8e-88 NP_060796 (OMIM: 608087) GTPase IMAP family member ( 329) 166 42.8 0.0016 XP_005250074 (OMIM: 608087) PREDICTED: GTPase IMAP ( 343) 166 42.8 0.0016 NP_598399 (OMIM: 608536,616198) tRNA modification ( 524) 164 42.6 0.003 >>NP_005693 (OMIM: 607435) GTPase Era, mitochondrial iso (437 aa) initn: 2918 init1: 2918 opt: 2918 Z-score: 3131.4 bits: 588.5 E(85289): 1.1e-167 Smith-Waterman score: 2918; 100.0% identity (100.0% similar) in 437 aa overlap (1-437:1-437) 10 20 30 40 50 60 pF1KE5 MAAPSWRGARLVQSVLRVWQVGPHVARERVIPFSSLLGFQRRCVSCVAGSAFSGPRLASA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 MAAPSWRGARLVQSVLRVWQVGPHVARERVIPFSSLLGFQRRCVSCVAGSAFSGPRLASA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE5 SRSNGQGSALDHFLGFSQPDSSVTPCVPAVSMNRDEQDVLLVHHPDMPENSRVLRVVLLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 SRSNGQGSALDHFLGFSQPDSSVTPCVPAVSMNRDEQDVLLVHHPDMPENSRVLRVVLLG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE5 APNAGKSTLSNQLLGRKVFPVSRKVHTTRCQALGVITEKETQVILLDTPGIISPGKQKRH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 APNAGKSTLSNQLLGRKVFPVSRKVHTTRCQALGVITEKETQVILLDTPGIISPGKQKRH 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE5 HLELSLLEDPWKSMESADLVVVLVDVSDKWTRNQLSPQLLRCLTKYSQIPSVLVMNKVDC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 HLELSLLEDPWKSMESADLVVVLVDVSDKWTRNQLSPQLLRCLTKYSQIPSVLVMNKVDC 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE5 LKQKSVLLELTAALTEGVVNGKKLKMRQAFHSHPGTHCPSPAVKDPNTQSVGNPQRIGWP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 LKQKSVLLELTAALTEGVVNGKKLKMRQAFHSHPGTHCPSPAVKDPNTQSVGNPQRIGWP 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE5 HFKEIFMLSALSQEDVKTLKQYLLTQAQPGPWEYHSAVLTSQTPEEICANIIREKLLEHL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 HFKEIFMLSALSQEDVKTLKQYLLTQAQPGPWEYHSAVLTSQTPEEICANIIREKLLEHL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE5 PQEVPYNVQQKTAVWEEGPGGELVIQQKLLVPKESYVKLLIGPKGHVISQIAQEAGHDLM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 PQEVPYNVQQKTAVWEEGPGGELVIQQKLLVPKESYVKLLIGPKGHVISQIAQEAGHDLM 370 380 390 400 410 420 430 pF1KE5 DIFLCDVDIRLSVKLLK ::::::::::::::::: NP_005 DIFLCDVDIRLSVKLLK 430 >>NP_001304914 (OMIM: 607435) GTPase Era, mitochondrial (436 aa) initn: 1829 init1: 1829 opt: 2901 Z-score: 3113.2 bits: 585.2 E(85289): 1.1e-166 Smith-Waterman score: 2901; 99.8% identity (99.8% similar) in 437 aa overlap (1-437:1-436) 10 20 30 40 50 60 pF1KE5 MAAPSWRGARLVQSVLRVWQVGPHVARERVIPFSSLLGFQRRCVSCVAGSAFSGPRLASA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MAAPSWRGARLVQSVLRVWQVGPHVARERVIPFSSLLGFQRRCVSCVAGSAFSGPRLASA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE5 SRSNGQGSALDHFLGFSQPDSSVTPCVPAVSMNRDEQDVLLVHHPDMPENSRVLRVVLLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SRSNGQGSALDHFLGFSQPDSSVTPCVPAVSMNRDEQDVLLVHHPDMPENSRVLRVVLLG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE5 APNAGKSTLSNQLLGRKVFPVSRKVHTTRCQALGVITEKETQVILLDTPGIISPGKQKRH :::::::::::::::::::::::::::::::::::::::::: ::::::::::::::::: NP_001 APNAGKSTLSNQLLGRKVFPVSRKVHTTRCQALGVITEKETQ-ILLDTPGIISPGKQKRH 130 140 150 160 170 190 200 210 220 230 240 pF1KE5 HLELSLLEDPWKSMESADLVVVLVDVSDKWTRNQLSPQLLRCLTKYSQIPSVLVMNKVDC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HLELSLLEDPWKSMESADLVVVLVDVSDKWTRNQLSPQLLRCLTKYSQIPSVLVMNKVDC 180 190 200 210 220 230 250 260 270 280 290 300 pF1KE5 LKQKSVLLELTAALTEGVVNGKKLKMRQAFHSHPGTHCPSPAVKDPNTQSVGNPQRIGWP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LKQKSVLLELTAALTEGVVNGKKLKMRQAFHSHPGTHCPSPAVKDPNTQSVGNPQRIGWP 240 250 260 270 280 290 310 320 330 340 350 360 pF1KE5 HFKEIFMLSALSQEDVKTLKQYLLTQAQPGPWEYHSAVLTSQTPEEICANIIREKLLEHL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HFKEIFMLSALSQEDVKTLKQYLLTQAQPGPWEYHSAVLTSQTPEEICANIIREKLLEHL 300 310 320 330 340 350 370 380 390 400 410 420 pF1KE5 PQEVPYNVQQKTAVWEEGPGGELVIQQKLLVPKESYVKLLIGPKGHVISQIAQEAGHDLM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PQEVPYNVQQKTAVWEEGPGGELVIQQKLLVPKESYVKLLIGPKGHVISQIAQEAGHDLM 360 370 380 390 400 410 430 pF1KE5 DIFLCDVDIRLSVKLLK ::::::::::::::::: NP_001 DIFLCDVDIRLSVKLLK 420 430 >>NP_001304915 (OMIM: 607435) GTPase Era, mitochondrial (354 aa) initn: 1577 init1: 1577 opt: 1580 Z-score: 1699.0 bits: 323.2 E(85289): 6.8e-88 Smith-Waterman score: 2181; 81.0% identity (81.0% similar) in 437 aa overlap (1-437:1-354) 10 20 30 40 50 60 pF1KE5 MAAPSWRGARLVQSVLRVWQVGPHVARERVIPFSSLLGFQRRCVSCVAGSAFSGPRLASA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MAAPSWRGARLVQSVLRVWQVGPHVARERVIPFSSLLGFQRRCVSCVAGSAFSGPRLASA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE5 SRSNGQGSALDHFLGFSQPDSSVTPCVPAVSMNRDEQDVLLVHHPDMPENSRVLRVVLLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SRSNGQGSALDHFLGFSQPDSSVTPCVPAVSMNRDEQDVLLVHHPDMPENSRVLRVVLLG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE5 APNAGKSTLSNQLLGRKVFPVSRKVHTTRCQALGVITEKETQVILLDTPGIISPGKQKRH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 APNAGKSTLSNQLLGRKVFPVSRKVHTTRCQALGVITEKETQVILLDTPGIISPGKQKRH 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE5 HLELSLLEDPWKSMESADLVVVLVDVSDKWTRNQLSPQLLRCLTKYSQIPSVLVMNKVDC ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HLELSLLEDPWKSMESADLVVVLVDVSDKWTRNQLSPQLLRCLTKYSQIPSVLVMNK--- 190 200 210 220 230 250 260 270 280 290 300 pF1KE5 LKQKSVLLELTAALTEGVVNGKKLKMRQAFHSHPGTHCPSPAVKDPNTQSVGNPQRIGWP NP_001 ------------------------------------------------------------ 310 320 330 340 350 360 pF1KE5 HFKEIFMLSALSQEDVKTLKQYLLTQAQPGPWEYHSAVLTSQTPEEICANIIREKLLEHL :::::::::::::::::::::::::::::::::::::::: NP_001 --------------------QYLLTQAQPGPWEYHSAVLTSQTPEEICANIIREKLLEHL 240 250 260 270 370 380 390 400 410 420 pF1KE5 PQEVPYNVQQKTAVWEEGPGGELVIQQKLLVPKESYVKLLIGPKGHVISQIAQEAGHDLM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PQEVPYNVQQKTAVWEEGPGGELVIQQKLLVPKESYVKLLIGPKGHVISQIAQEAGHDLM 280 290 300 310 320 330 430 pF1KE5 DIFLCDVDIRLSVKLLK ::::::::::::::::: NP_001 DIFLCDVDIRLSVKLLK 340 350 >>NP_060796 (OMIM: 608087) GTPase IMAP family member 4 [ (329 aa) initn: 180 init1: 104 opt: 166 Z-score: 184.3 bits: 42.8 E(85289): 0.0016 Smith-Waterman score: 171; 28.3% identity (64.5% similar) in 166 aa overlap (82-241:9-159) 60 70 80 90 100 110 pF1KE5 FSGPRLASASRSNGQGSALDHFLGFSQPDSSVTPCVPAVSMNRDEQDVLLVHHPDMPENS : .: .:..:.. .:. :.:: NP_060 MAAQYGSMSFNPSTPGASYGPGRQE---------PRNS 10 20 120 130 140 150 160 pF1KE5 RVLRVVLLGAPNAGKSTLSNQLLGRKVFP--VSRKVHTTRCQALGVITEKETQVILLDTP . ::.::.: .::::. .:..:::::: .. : : .:. . . :::.....::: NP_060 Q-LRIVLVGKTGAGKSATGNSILGRKVFHSGTAAKSITKKCEKRSS-SWKETELVVVDTP 30 40 50 60 70 80 170 180 190 200 210 220 pF1KE5 GIIS---PGKQ-KRHHLELSLLEDPWKSMESADLVVVLVDVSDKWTRNQLSPQLLRCLTK ::.. :. . ... .. :: .: . .. ::: : ... ... . ..:. . . NP_060 GIFDTEVPNAETSKEIIRCILLTSP--GPHALLLVVPLGRYTEE--EHKATEKILKMFGE 90 100 110 120 130 140 230 240 250 260 270 280 pF1KE5 YSQIPSVLVMNKVDCLKQKSVLLELTAALTEGVVNGKKLKMRQAFHSHPGTHCPSPAVKD .. .:.... : : NP_060 RARSFMILIFTRKDDLGDTNLHDYLREAPEDIQDLMDIFGDRYCALNNKATGAEQEAQRA 150 160 170 180 190 200 >>XP_005250074 (OMIM: 608087) PREDICTED: GTPase IMAP fam (343 aa) initn: 180 init1: 104 opt: 166 Z-score: 184.1 bits: 42.8 E(85289): 0.0016 Smith-Waterman score: 166; 30.0% identity (67.1% similar) in 140 aa overlap (108-241:40-173) 80 90 100 110 120 130 pF1KE5 QPDSSVTPCVPAVSMNRDEQDVLLVHHPDMPENSRVLRVVLLGAPNAGKSTLSNQLLGRK :.::. ::.::.: .::::. .:..:::: XP_005 FNPSTPGASYGERAFSAPQTRLQGGPGRQEPRNSQ-LRIVLVGKTGAGKSATGNSILGRK 10 20 30 40 50 60 140 150 160 170 180 190 pF1KE5 VFP--VSRKVHTTRCQALGVITEKETQVILLDTPGIIS---PGKQ-KRHHLELSLLEDPW :: .. : : .:. . . :::.....:::::.. :. . ... .. :: .: XP_005 VFHSGTAAKSITKKCEKRSS-SWKETELVVVDTPGIFDTEVPNAETSKEIIRCILLTSP- 70 80 90 100 110 120 200 210 220 230 240 250 pF1KE5 KSMESADLVVVLVDVSDKWTRNQLSPQLLRCLTKYSQIPSVLVMNKVDCLKQKSVLLELT . .. ::: : ... ... . ..:. . . .. .:.... : : XP_005 -GPHALLLVVPLGRYTEE--EHKATEKILKMFGERARSFMILIFTRKDDLGDTNLHDYLR 130 140 150 160 170 180 260 270 280 290 300 310 pF1KE5 AALTEGVVNGKKLKMRQAFHSHPGTHCPSPAVKDPNTQSVGNPQRIGWPHFKEIFMLSAL XP_005 EAPEDIQDLMDIFGDRYCALNNKATGAEQEAQRAQLLGLIQRVVRENKEGCYTNRMYQRA 190 200 210 220 230 240 >>NP_598399 (OMIM: 608536,616198) tRNA modification GTPa (524 aa) initn: 189 init1: 96 opt: 164 Z-score: 179.4 bits: 42.6 E(85289): 0.003 Smith-Waterman score: 164; 26.7% identity (54.7% similar) in 236 aa overlap (67-286:229-459) 40 50 60 70 80 90 pF1KE5 LGFQRRCVSCVAGSAFSGPRLASASRSNGQGSALDHFLGFSQPDSSVTPCV--PAVSMN- : :. :. :.. :. :..... NP_598 LAHVEAYIDFGEDDNLEEGVLEQGGSTWWWGRKTPHISPQRLPSLSLSACLLSPTADIEV 200 210 220 230 240 250 100 110 120 130 140 pF1KE5 RDEQDVLLVHHPDMPENSRV---LRVVLLGAPNAGKSTLSNQLLGRK-VFPVSRKVHTTR : : .: .: : ...:. ..::. : ::::::.: : ::.:: : :: . ::: NP_598 RALQVALGAHLRDARRGQRLRSGVHVVVTGPPNAGKSSLVN-LLSRKPVSIVSPEPGTTR 260 270 280 290 300 310 150 160 170 180 190 200 pF1KE5 CQALGVITEKETQVILLDTPGIISPGKQKRHHLELSLLEDPWKSMESADLVVVLVDVSDK . :.: :: :. .. .: .. . .:.:::.....:.:: NP_598 DVLETPVDLAGFPVLLSDTAGL----REGVGPVEQEGVRRARERLEQADLILAMLDASDL 320 330 340 350 360 370 210 220 230 240 250 260 pF1KE5 WTRNQLSPQLLRCLTKYSQIPS------VLVMNKVDCLKQKSVLL--ELTAALTEGVVNG . .. . . .: :: .::.:: : :. .. .: : . ..: NP_598 ASPSSCNFLATVVASVGAQSPSDSSQRLLLVLNKSDLLSPEGPGPGPDLPPHLLLSCLTG 380 390 400 410 420 430 270 280 290 300 310 320 pF1KE5 KKLK-MRQAFHSHPGTHCPSPAVKDPNTQSVGNPQRIGWPHFKEIFMLSALSQEDVKTLK . : . .:.... .. : .:.. : NP_598 EGLDGLLEALRKELAAVCGDPSTDPPLLTRARHQHHLQGCLDALGHYKQSKDLALAAEAL 440 450 460 470 480 490 437 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Nov 8 01:20:04 2016 done: Tue Nov 8 01:20:05 2016 Total Scan time: 8.530 Total Display time: 0.010 Function used was FASTA [36.3.4 Apr, 2011]