FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE1476, 655 aa 1>>>pF1KE1476 655 - 655 aa - 655 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 7.8848+/-0.000349; mu= 8.0292+/- 0.022 mean_var=152.4848+/-30.696, 0's: 0 Z-trim(118.6): 62 B-trim: 525 in 2/57 Lambda= 0.103863 statistics sampled from 31602 (31664) to 31602 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.717), E-opt: 0.2 (0.371), width: 16 Scan time: 12.730 The best scores are: opt bits E(85289) NP_055267 (OMIM: 605732) tumor necrosis factor rec ( 655) 4427 675.5 1.7e-193 XP_016866233 (OMIM: 605732) PREDICTED: tumor necro ( 444) 2859 440.4 6.6e-123 NP_002537 (OMIM: 239000,602643) tumor necrosis fac ( 401) 417 74.5 8.6e-13 NP_003814 (OMIM: 603361) tumor necrosis factor rec ( 300) 412 73.6 1.1e-12 XP_016857701 (OMIM: 191191) PREDICTED: tumor necro ( 440) 414 74.0 1.3e-12 XP_016857702 (OMIM: 191191) PREDICTED: tumor necro ( 440) 414 74.0 1.3e-12 NP_001057 (OMIM: 191191) tumor necrosis factor rec ( 461) 414 74.1 1.3e-12 XP_011540365 (OMIM: 191191) PREDICTED: tumor necro ( 462) 414 74.1 1.3e-12 XP_011540362 (OMIM: 191191) PREDICTED: tumor necro ( 484) 414 74.1 1.4e-12 XP_016857700 (OMIM: 191191) PREDICTED: tumor necro ( 491) 414 74.1 1.4e-12 XP_005253745 (OMIM: 600979) PREDICTED: tumor necro ( 399) 344 63.5 1.7e-09 XP_006719046 (OMIM: 600979) PREDICTED: tumor necro ( 255) 337 62.4 2.4e-09 NP_002333 (OMIM: 600979) tumor necrosis factor rec ( 435) 337 62.5 3.7e-09 NP_001257916 (OMIM: 600979) tumor necrosis factor ( 416) 332 61.7 6e-09 XP_006710681 (OMIM: 602250) PREDICTED: tumor necro ( 239) 319 59.6 1.5e-08 XP_011539688 (OMIM: 602250) PREDICTED: tumor necro ( 255) 319 59.7 1.6e-08 NP_001552 (OMIM: 602250) tumor necrosis factor rec ( 255) 319 59.7 1.6e-08 NP_001289682 (OMIM: 109535,606843) tumor necrosis ( 237) 305 57.5 6.3e-08 XP_016883624 (OMIM: 109535,606843) PREDICTED: tumo ( 323) 305 57.6 8.1e-08 NP_001257878 (OMIM: 174810,602080,603499,612301) t ( 263) 295 56.1 1.9e-07 NP_001257879 (OMIM: 174810,602080,603499,612301) t ( 337) 295 56.1 2.4e-07 NP_003811 (OMIM: 602746) tumor necrosis factor rec ( 283) 290 55.3 3.5e-07 NP_001309350 (OMIM: 109535,606843) tumor necrosis ( 281) 289 55.2 3.8e-07 NP_003830 (OMIM: 174810,602080,603499,612301) tumo ( 616) 295 56.3 3.9e-07 NP_001257880 (OMIM: 174810,602080,603499,612301) t ( 299) 286 54.8 5.5e-07 XP_016883626 (OMIM: 109535,606843) PREDICTED: tumo ( 222) 281 53.9 7.2e-07 XP_006711082 (OMIM: 602746) PREDICTED: tumor necro ( 197) 279 53.6 8.1e-07 NP_001241 (OMIM: 109535,606843) tumor necrosis fac ( 277) 281 54.0 8.7e-07 NP_001284534 (OMIM: 602746) tumor necrosis factor ( 184) 277 53.3 9.4e-07 XP_011524546 (OMIM: 174810,602080,603499,612301) P ( 621) 282 54.4 1.5e-06 XP_016881554 (OMIM: 174810,602080,603499,612301) P ( 566) 233 47.0 0.00023 NP_690593 (OMIM: 109535,606843) tumor necrosis fac ( 203) 202 42.1 0.0025 NP_003832 (OMIM: 603613) tumor necrosis factor rec ( 259) 203 42.3 0.0027 XP_016883625 (OMIM: 109535,606843) PREDICTED: tumo ( 289) 202 42.2 0.0033 >>NP_055267 (OMIM: 605732) tumor necrosis factor recepto (655 aa) initn: 4427 init1: 4427 opt: 4427 Z-score: 3594.9 bits: 675.5 E(85289): 1.7e-193 Smith-Waterman score: 4427; 100.0% identity (100.0% similar) in 655 aa overlap (1-655:1-655) 10 20 30 40 50 60 pF1KE1 MGTSPSSSTALASCSRIARRATATMIAGSLLLLGFLSTTTAQPEQKASNLIGTYRHVDRA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 MGTSPSSSTALASCSRIARRATATMIAGSLLLLGFLSTTTAQPEQKASNLIGTYRHVDRA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 TGQVLTCDKCPAGTYVSEHCTNTSLRVCSSCPVGTFTRHENGIEKCHDCSQPCPWPMIEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 TGQVLTCDKCPAGTYVSEHCTNTSLRVCSSCPVGTFTRHENGIEKCHDCSQPCPWPMIEK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 LPCAALTDRECTCPPGMFQSNATCAPHTVCPVGWGVRKKGTETEDVRCKQCARGTFSDVP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 LPCAALTDRECTCPPGMFQSNATCAPHTVCPVGWGVRKKGTETEDVRCKQCARGTFSDVP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 SSVMKCKAYTDCLSQNLVVIKPGTKETDNVCGTLPSFSSSTSPSPGTAIFPRPEHMETHE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 SSVMKCKAYTDCLSQNLVVIKPGTKETDNVCGTLPSFSSSTSPSPGTAIFPRPEHMETHE 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE1 VPSSTYVPKGMNSTESNSSASVRPKVLSSIQEGTVPDNTSSARGKEDVNKTLPNLQVVNH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 VPSSTYVPKGMNSTESNSSASVRPKVLSSIQEGTVPDNTSSARGKEDVNKTLPNLQVVNH 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE1 QQGPHHRHILKLLPSMEATGGEKSSTPIKGPKRGHPRQNLHKHFDINEHLPWMIVLFLLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 QQGPHHRHILKLLPSMEATGGEKSSTPIKGPKRGHPRQNLHKHFDINEHLPWMIVLFLLL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE1 VLVVIVVCSIRKSSRTLKKGPRQDPSAIVEKAGLKKSMTPTQNREKWIYYCNGHGIDILK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 VLVVIVVCSIRKSSRTLKKGPRQDPSAIVEKAGLKKSMTPTQNREKWIYYCNGHGIDILK 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE1 LVAAQVGSQWKDIYQFLCNASEREVAAFSNGYTADHERAYAALQHWTIRGPEASLAQLIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 LVAAQVGSQWKDIYQFLCNASEREVAAFSNGYTADHERAYAALQHWTIRGPEASLAQLIS 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE1 ALRQHRRNDVVEKIRGLMEDTTQLETDKLALPMSPSPLSPSPIPSPNAKLENSALLTVEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 ALRQHRRNDVVEKIRGLMEDTTQLETDKLALPMSPSPLSPSPIPSPNAKLENSALLTVEP 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE1 SPQDKNKGFFVDESEPLLRCDSTSSGSSALSRNGSFITKEKKDTVLRQVRLDPCDLQPIF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 SPQDKNKGFFVDESEPLLRCDSTSSGSSALSRNGSFITKEKKDTVLRQVRLDPCDLQPIF 550 560 570 580 590 600 610 620 630 640 650 pF1KE1 DDMLHFLNPEELRVIEEIPQAEDKLDRLFEIIGVKSQEASQTLLDSVYSHLPDLL ::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 DDMLHFLNPEELRVIEEIPQAEDKLDRLFEIIGVKSQEASQTLLDSVYSHLPDLL 610 620 630 640 650 >>XP_016866233 (OMIM: 605732) PREDICTED: tumor necrosis (444 aa) initn: 2859 init1: 2859 opt: 2859 Z-score: 2327.6 bits: 440.4 E(85289): 6.6e-123 Smith-Waterman score: 2859; 100.0% identity (100.0% similar) in 415 aa overlap (1-415:1-415) 10 20 30 40 50 60 pF1KE1 MGTSPSSSTALASCSRIARRATATMIAGSLLLLGFLSTTTAQPEQKASNLIGTYRHVDRA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MGTSPSSSTALASCSRIARRATATMIAGSLLLLGFLSTTTAQPEQKASNLIGTYRHVDRA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 TGQVLTCDKCPAGTYVSEHCTNTSLRVCSSCPVGTFTRHENGIEKCHDCSQPCPWPMIEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TGQVLTCDKCPAGTYVSEHCTNTSLRVCSSCPVGTFTRHENGIEKCHDCSQPCPWPMIEK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 LPCAALTDRECTCPPGMFQSNATCAPHTVCPVGWGVRKKGTETEDVRCKQCARGTFSDVP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LPCAALTDRECTCPPGMFQSNATCAPHTVCPVGWGVRKKGTETEDVRCKQCARGTFSDVP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 SSVMKCKAYTDCLSQNLVVIKPGTKETDNVCGTLPSFSSSTSPSPGTAIFPRPEHMETHE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SSVMKCKAYTDCLSQNLVVIKPGTKETDNVCGTLPSFSSSTSPSPGTAIFPRPEHMETHE 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE1 VPSSTYVPKGMNSTESNSSASVRPKVLSSIQEGTVPDNTSSARGKEDVNKTLPNLQVVNH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VPSSTYVPKGMNSTESNSSASVRPKVLSSIQEGTVPDNTSSARGKEDVNKTLPNLQVVNH 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE1 QQGPHHRHILKLLPSMEATGGEKSSTPIKGPKRGHPRQNLHKHFDINEHLPWMIVLFLLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QQGPHHRHILKLLPSMEATGGEKSSTPIKGPKRGHPRQNLHKHFDINEHLPWMIVLFLLL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE1 VLVVIVVCSIRKSSRTLKKGPRQDPSAIVEKAGLKKSMTPTQNREKWIYYCNGHGIDILK ::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VLVVIVVCSIRKSSRTLKKGPRQDPSAIVEKAGLKKSMTPTQNREKWIYYCNGHGPHDEE 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE1 LVAAQVGSQWKDIYQFLCNASEREVAAFSNGYTADHERAYAALQHWTIRGPEASLAQLIS XP_016 WGLMERHIQDIYIQRSNQDSERWG 430 440 >>NP_002537 (OMIM: 239000,602643) tumor necrosis factor (401 aa) initn: 475 init1: 378 opt: 417 Z-score: 350.6 bits: 74.5 E(85289): 8.6e-13 Smith-Waterman score: 417; 28.5% identity (50.0% similar) in 288 aa overlap (54-334:28-308) 30 40 50 60 70 80 pF1KE1 TMIAGSLLLLGFLSTTTAQPEQKASNLIGTYRHVDRATGQVLTCDKCPAGTYVSEHCTNT : : :. :.. : ::::: :::...::: NP_002 MNNLLCCALVFLDISIKWTTQETFPPKYLHYDEETSHQLLCDKCPPGTYLKQHCTAK 10 20 30 40 50 90 100 110 120 130 140 pF1KE1 SLRVCSSCPVGTFTRHENGIEKCHDCSQPCPWPMIEKLPCAALTDRECTCPPGMFQSNAT ::. :: .: . ..: :: : . : : .: : : : . NP_002 WKTVCAPCPDHYYTDSWHTSDECLYCSPVCKELQYVKQECNRTHNRVCECKEGRYLEIEF 60 70 80 90 100 110 150 160 170 180 190 200 pF1KE1 CAPHTVCPVGWGVRKKGTETEDVRCKQCARGTFSDVPSSVMKCKAYTDCLSQNLVVIKPG : : :: :.:: . :: ... ::.: : ::. :: :. .:.: .:.. . : NP_002 CLKHRSCPPGFGVVQAGTPERNTVCKRCPDGFFSNETSSKAPCRKHTNCSVFGLLLTQKG 120 130 140 150 160 170 210 220 230 240 250 pF1KE1 TKETDNVCGTLPSFSSSTSPSPGTAIFPRPEHMETHEVPSSTYVPKGMN-------STES . ::.: : .: .. . : . : . ::.. ..:. .. .:. NP_002 NATHDNIC----SGNSESTQKCGIDVTLCEEAFFRFAVPTK-FTPNWLSVLVDNLPGTKV 180 190 200 210 220 230 260 270 280 290 300 310 pF1KE1 NSSASVRPKVLSSIQEGTVPDNTSSARGKEDVNKTLPNLQVVNHQQGPHHRHILKLLPSM :. . : : : :: : . ..: . . .: .. .. .::: . .. NP_002 NAESVERIKRQHSSQEQTFQLLKLWKHQNKDQDIVKKIIQDIDLCENSVQRHIGHANLTF 240 250 260 270 280 290 320 330 340 350 360 370 pF1KE1 EATGGEKSSTPIKGPKRGHPRQNLHKHFDINEHLPWMIVLFLLLVLVVIVVCSIRKSSRT : . : : : : : NP_002 EQLRSLMESLP--GKKVGAEDIEKTIKACKPSDQILKLLSLWRIKNGDQDTLKGLMHALK 300 310 320 330 340 350 >>NP_003814 (OMIM: 603361) tumor necrosis factor recepto (300 aa) initn: 408 init1: 408 opt: 412 Z-score: 348.4 bits: 73.6 E(85289): 1.1e-12 Smith-Waterman score: 412; 33.2% identity (54.3% similar) in 199 aa overlap (29-226:10-207) 10 20 30 40 50 pF1KE1 MGTSPSSSTALASCSRIARRATATMIAGSLLLLGF-LSTTTAQPEQKASNLIGTYRHVDR ::: : . : . : .. :: : NP_003 MRALEGPGLSLLCLVLALPALLPVPAVRGVAETPTYPWRDA 10 20 30 40 60 70 80 90 100 110 pF1KE1 ATGQVLTCDKCPAGTYVSEHCTNTSLRVCSSCPVGTFTRHENGIEKCHDCSQPCPWPMIE ::. :.: .:: ::.:.. : : .:. :: .:. : .:.:. :. : : NP_003 ETGERLVCAQCPPGTFVQRPCRRDSPTTCGPCPPRHYTQFWNYLERCRYCNVLCGEREEE 50 60 70 80 90 100 120 130 140 150 160 170 pF1KE1 KLPCAALTDRECTCPPGMFQSNATCAPHTVCPVGWGVRKKGTETEDVRCKQCARGTFSDV : : .: : : :.: . : :. :: : :: :: .....:. : :::: NP_003 ARACHATHNRACRCRTGFFAHAGFCLEHASCPPGAGVIAPGTPSQNTQCQPCPPGTFSAS 110 120 130 140 150 160 180 190 200 210 220 230 pF1KE1 PSSVMKCKAYTDCLSQNLVVIKPGTKETDNVCGTLPSFSSSTSPSPGTAIFPRPEHMETH :: .:. . .: . .:.. ::.. :..: . .: :: :: NP_003 SSSSEQCQPHRNCTALGLALNVPGSSSHDTLCTSCTGFPLSTR-VPGAEECERAVIDFVA 170 180 190 200 210 220 240 250 260 270 280 290 pF1KE1 EVPSSTYVPKGMNSTESNSSASVRPKVLSSIQEGTVPDNTSSARGKEDVNKTLPNLQVVN NP_003 FQDISIKRLQRLLQALEAPEGWGPTPRAGRAALQLKLRRRLTELLGAQDGALLVRLLQAL 230 240 250 260 270 280 >>XP_016857701 (OMIM: 191191) PREDICTED: tumor necrosis (440 aa) initn: 421 init1: 187 opt: 414 Z-score: 347.6 bits: 74.0 E(85289): 1.3e-12 Smith-Waterman score: 414; 35.8% identity (59.1% similar) in 193 aa overlap (65-248:1-186) 40 50 60 70 80 90 pF1KE1 FLSTTTAQPEQKASNLIGTYRHVDRATGQVLTCDKCPAGTYVSEHCTNTSLRVCSSCPVG . :.:: : ... ::.:: ::.:: . XP_016 MCCSKCSPGQHAKVFCTKTSDTVCDSCEDS 10 20 30 100 110 120 130 140 pF1KE1 TFTRHENGIEKCHDCSQPCPWPMIEKLPCAALTDRECTCPPGMF------QSNATCAPHT :.:. : . .: .:.. : ..: :. .: ::: :: . .. ::: XP_016 TYTQLWNWVPECLSCGSRCSSDQVETQACTREQNRICTCRPGWYCALSKQEGCRLCAPLR 40 50 60 70 80 90 150 160 170 180 190 200 pF1KE1 VCPVGWGVRKKGTETEDVRCKQCARGTFSDVPSSVMKCKAYTDCLSQNLVVIKPGTKETD : :.:: . :::: :: :: :: ::::.. ::. :. . : :.:.: ::. : XP_016 KCRPGFGVARPGTETSDVVCKPCAPGTFSNTTSSTDICRPHQIC---NVVAI-PGNASMD 100 110 120 130 140 210 220 230 240 250 260 pF1KE1 NVCGTLPSFSSSTSPSPGTAIFPRP---EHMETHEVPSSTYVPKGMNSTESNSSASVRPK :: : : . : .::.. .:.: . ..:. .: . .: XP_016 AVC---TSTSPTRSMAPGAVHLPQPVSTRSQHTQPTPEPSTAPSTSFLLPMGPSPPAEGS 150 160 170 180 190 200 270 280 290 300 310 320 pF1KE1 VLSSIQEGTVPDNTSSARGKEDVNKTLPNLQVVNHQQGPHHRHILKLLPSMEATGGEKSS XP_016 TGDFALPVGLIVGVTALGLLIIGVVNCVIMTQVKKKPLCLQREAKVVSVSTALSPSSPGL 210 220 230 240 250 260 >>XP_016857702 (OMIM: 191191) PREDICTED: tumor necrosis (440 aa) initn: 421 init1: 187 opt: 414 Z-score: 347.6 bits: 74.0 E(85289): 1.3e-12 Smith-Waterman score: 414; 35.8% identity (59.1% similar) in 193 aa overlap (65-248:1-186) 40 50 60 70 80 90 pF1KE1 FLSTTTAQPEQKASNLIGTYRHVDRATGQVLTCDKCPAGTYVSEHCTNTSLRVCSSCPVG . :.:: : ... ::.:: ::.:: . XP_016 MCCSKCSPGQHAKVFCTKTSDTVCDSCEDS 10 20 30 100 110 120 130 140 pF1KE1 TFTRHENGIEKCHDCSQPCPWPMIEKLPCAALTDRECTCPPGMF------QSNATCAPHT :.:. : . .: .:.. : ..: :. .: ::: :: . .. ::: XP_016 TYTQLWNWVPECLSCGSRCSSDQVETQACTREQNRICTCRPGWYCALSKQEGCRLCAPLR 40 50 60 70 80 90 150 160 170 180 190 200 pF1KE1 VCPVGWGVRKKGTETEDVRCKQCARGTFSDVPSSVMKCKAYTDCLSQNLVVIKPGTKETD : :.:: . :::: :: :: :: ::::.. ::. :. . : :.:.: ::. : XP_016 KCRPGFGVARPGTETSDVVCKPCAPGTFSNTTSSTDICRPHQIC---NVVAI-PGNASMD 100 110 120 130 140 210 220 230 240 250 260 pF1KE1 NVCGTLPSFSSSTSPSPGTAIFPRP---EHMETHEVPSSTYVPKGMNSTESNSSASVRPK :: : : . : .::.. .:.: . ..:. .: . .: XP_016 AVC---TSTSPTRSMAPGAVHLPQPVSTRSQHTQPTPEPSTAPSTSFLLPMGPSPPAEGS 150 160 170 180 190 200 270 280 290 300 310 320 pF1KE1 VLSSIQEGTVPDNTSSARGKEDVNKTLPNLQVVNHQQGPHHRHILKLLPSMEATGGEKSS XP_016 TGDFALPVGLIVGVTALGLLIIGVVNCVIMTQVKKKPLCLQREAKVVSVSTALSPSSPGL 210 220 230 240 250 260 >>NP_001057 (OMIM: 191191) tumor necrosis factor recepto (461 aa) initn: 429 init1: 187 opt: 414 Z-score: 347.3 bits: 74.1 E(85289): 1.3e-12 Smith-Waterman score: 445; 30.2% identity (55.4% similar) in 305 aa overlap (65-337:52-349) 40 50 60 70 80 90 pF1KE1 FLSTTTAQPEQKASNLIGTYRHVDRATGQVLTCDKCPAGTYVSEHCTNTSLRVCSSCPVG . :.:: : ... ::.:: ::.:: . NP_001 ALPAQVAFTPYAPEPGSTCRLREYYDQTAQMCCSKCSPGQHAKVFCTKTSDTVCDSCEDS 30 40 50 60 70 80 100 110 120 130 140 pF1KE1 TFTRHENGIEKCHDCSQPCPWPMIEKLPCAALTDRECTCPPGMF------QSNATCAPHT :.:. : . .: .:.. : ..: :. .: ::: :: . .. ::: NP_001 TYTQLWNWVPECLSCGSRCSSDQVETQACTREQNRICTCRPGWYCALSKQEGCRLCAPLR 90 100 110 120 130 140 150 160 170 180 190 200 pF1KE1 VCPVGWGVRKKGTETEDVRCKQCARGTFSDVPSSVMKCKAYTDCLSQNLVVIKPGTKETD : :.:: . :::: :: :: :: ::::.. ::. :. . : :.:.: ::. : NP_001 KCRPGFGVARPGTETSDVVCKPCAPGTFSNTTSSTDICRPHQIC---NVVAI-PGNASMD 150 160 170 180 190 210 220 230 240 250 pF1KE1 NVCGTLPSFSSSTSPSPGTAIFPRP-----EHM----ETHEVPSSTYV-PKGMNSTESNS :: : : . : .::.. .:.: .: : .::.... : : . .: NP_001 AVC---TSTSPTRSMAPGAVHLPQPVSTRSQHTQPTPEPSTAPSTSFLLPMGPSPPAEGS 200 210 220 230 240 250 260 270 280 290 300 pF1KE1 SAS--------VRPKVLSSIQEGTVPDNTSSARGKEDV----NKTLPNLQV--VNHQQGP ... : .:. . :.: . :. . . .:.: . . ::: NP_001 TGDFALPVGLIVGVTALGLLIIGVVNCVIMTQVKKKPLCLQREAKVPHLPADKARGTQGP 260 270 280 290 300 310 310 320 330 340 350 360 pF1KE1 HHRHILKLLPSMEATGGEKSSTPI--KGPKRGHPRQNLHKHFDINEHLPWMIVLFLLLVL ...:.: :: ... :.:.. . ..: :..:. NP_001 EQQHLLITAPSSSSSSLESSASALDRRAPTRNQPQAPGVEASGAGEARASTGSSDSSPGG 320 330 340 350 360 370 370 380 390 400 410 420 pF1KE1 VVIVVCSIRKSSRTLKKGPRQDPSAIVEKAGLKKSMTPTQNREKWIYYCNGHGIDILKLV NP_001 HGTQVNVTCIVNVCSSSDHSSQCSSQASSTMGDTDSSPSESPKDEQVPFSKEECAFRSQL 380 390 400 410 420 430 >>XP_011540365 (OMIM: 191191) PREDICTED: tumor necrosis (462 aa) initn: 429 init1: 187 opt: 414 Z-score: 347.3 bits: 74.1 E(85289): 1.3e-12 Smith-Waterman score: 445; 30.2% identity (55.4% similar) in 305 aa overlap (65-337:52-349) 40 50 60 70 80 90 pF1KE1 FLSTTTAQPEQKASNLIGTYRHVDRATGQVLTCDKCPAGTYVSEHCTNTSLRVCSSCPVG . :.:: : ... ::.:: ::.:: . XP_011 ALPAQVAFTPYAPEPGSTCRLREYYDQTAQMCCSKCSPGQHAKVFCTKTSDTVCDSCEDS 30 40 50 60 70 80 100 110 120 130 140 pF1KE1 TFTRHENGIEKCHDCSQPCPWPMIEKLPCAALTDRECTCPPGMF------QSNATCAPHT :.:. : . .: .:.. : ..: :. .: ::: :: . .. ::: XP_011 TYTQLWNWVPECLSCGSRCSSDQVETQACTREQNRICTCRPGWYCALSKQEGCRLCAPLR 90 100 110 120 130 140 150 160 170 180 190 200 pF1KE1 VCPVGWGVRKKGTETEDVRCKQCARGTFSDVPSSVMKCKAYTDCLSQNLVVIKPGTKETD : :.:: . :::: :: :: :: ::::.. ::. :. . : :.:.: ::. : XP_011 KCRPGFGVARPGTETSDVVCKPCAPGTFSNTTSSTDICRPHQIC---NVVAI-PGNASMD 150 160 170 180 190 210 220 230 240 250 pF1KE1 NVCGTLPSFSSSTSPSPGTAIFPRP-----EHM----ETHEVPSSTYV-PKGMNSTESNS :: : : . : .::.. .:.: .: : .::.... : : . .: XP_011 AVC---TSTSPTRSMAPGAVHLPQPVSTRSQHTQPTPEPSTAPSTSFLLPMGPSPPAEGS 200 210 220 230 240 250 260 270 280 290 300 pF1KE1 SAS--------VRPKVLSSIQEGTVPDNTSSARGKEDV----NKTLPNLQV--VNHQQGP ... : .:. . :.: . :. . . .:.: . . ::: XP_011 TGDFALPVGLIVGVTALGLLIIGVVNCVIMTQVKKKPLCLQREAKVPHLPADKARGTQGP 260 270 280 290 300 310 310 320 330 340 350 360 pF1KE1 HHRHILKLLPSMEATGGEKSSTPI--KGPKRGHPRQNLHKHFDINEHLPWMIVLFLLLVL ...:.: :: ... :.:.. . ..: :..:. XP_011 EQQHLLITAPSSSSSSLESSASALDRRAPTRNQPQAPGVEASGAGEARASTGSSADSSPG 320 330 340 350 360 370 370 380 390 400 410 420 pF1KE1 VVIVVCSIRKSSRTLKKGPRQDPSAIVEKAGLKKSMTPTQNREKWIYYCNGHGIDILKLV XP_011 GHGTQVNVTCIVNVCSSSDHSSQCSSQASSTMGDTDSSPSESPKDEQVPFSKEECAFRSQ 380 390 400 410 420 430 >>XP_011540362 (OMIM: 191191) PREDICTED: tumor necrosis (484 aa) initn: 429 init1: 187 opt: 414 Z-score: 347.0 bits: 74.1 E(85289): 1.4e-12 Smith-Waterman score: 445; 30.2% identity (55.4% similar) in 305 aa overlap (65-337:52-349) 40 50 60 70 80 90 pF1KE1 FLSTTTAQPEQKASNLIGTYRHVDRATGQVLTCDKCPAGTYVSEHCTNTSLRVCSSCPVG . :.:: : ... ::.:: ::.:: . XP_011 ALPAQVAFTPYAPEPGSTCRLREYYDQTAQMCCSKCSPGQHAKVFCTKTSDTVCDSCEDS 30 40 50 60 70 80 100 110 120 130 140 pF1KE1 TFTRHENGIEKCHDCSQPCPWPMIEKLPCAALTDRECTCPPGMF------QSNATCAPHT :.:. : . .: .:.. : ..: :. .: ::: :: . .. ::: XP_011 TYTQLWNWVPECLSCGSRCSSDQVETQACTREQNRICTCRPGWYCALSKQEGCRLCAPLR 90 100 110 120 130 140 150 160 170 180 190 200 pF1KE1 VCPVGWGVRKKGTETEDVRCKQCARGTFSDVPSSVMKCKAYTDCLSQNLVVIKPGTKETD : :.:: . :::: :: :: :: ::::.. ::. :. . : :.:.: ::. : XP_011 KCRPGFGVARPGTETSDVVCKPCAPGTFSNTTSSTDICRPHQIC---NVVAI-PGNASMD 150 160 170 180 190 210 220 230 240 250 pF1KE1 NVCGTLPSFSSSTSPSPGTAIFPRP-----EHM----ETHEVPSSTYV-PKGMNSTESNS :: : : . : .::.. .:.: .: : .::.... : : . .: XP_011 AVC---TSTSPTRSMAPGAVHLPQPVSTRSQHTQPTPEPSTAPSTSFLLPMGPSPPAEGS 200 210 220 230 240 250 260 270 280 290 300 pF1KE1 SAS--------VRPKVLSSIQEGTVPDNTSSARGKEDV----NKTLPNLQV--VNHQQGP ... : .:. . :.: . :. . . .:.: . . ::: XP_011 TGDFALPVGLIVGVTALGLLIIGVVNCVIMTQVKKKPLCLQREAKVPHLPADKARGTQGP 260 270 280 290 300 310 310 320 330 340 350 360 pF1KE1 HHRHILKLLPSMEATGGEKSSTPI--KGPKRGHPRQNLHKHFDINEHLPWMIVLFLLLVL ...:.: :: ... :.:.. . ..: :..:. XP_011 EQQHLLITAPSSSSSSLESSASALDRRAPTRNQPQAPGVEASGAGEARASTGSSGLSDCM 320 330 340 350 360 370 370 380 390 400 410 420 pF1KE1 VVIVVCSIRKSSRTLKKGPRQDPSAIVEKAGLKKSMTPTQNREKWIYYCNGHGIDILKLV XP_011 YRHCLLLSPTPGCGTPADSSPGGHGTQVNVTCIVNVCSSSDHSSQCSSQASSTMGDTDSS 380 390 400 410 420 430 >>XP_016857700 (OMIM: 191191) PREDICTED: tumor necrosis (491 aa) initn: 421 init1: 187 opt: 414 Z-score: 346.9 bits: 74.1 E(85289): 1.4e-12 Smith-Waterman score: 414; 35.8% identity (59.1% similar) in 193 aa overlap (65-248:52-237) 40 50 60 70 80 90 pF1KE1 FLSTTTAQPEQKASNLIGTYRHVDRATGQVLTCDKCPAGTYVSEHCTNTSLRVCSSCPVG . :.:: : ... ::.:: ::.:: . XP_016 ALPAQVAFTPYAPEPGSTCRLREYYDQTAQMCCSKCSPGQHAKVFCTKTSDTVCDSCEDS 30 40 50 60 70 80 100 110 120 130 140 pF1KE1 TFTRHENGIEKCHDCSQPCPWPMIEKLPCAALTDRECTCPPGMF------QSNATCAPHT :.:. : . .: .:.. : ..: :. .: ::: :: . .. ::: XP_016 TYTQLWNWVPECLSCGSRCSSDQVETQACTREQNRICTCRPGWYCALSKQEGCRLCAPLR 90 100 110 120 130 140 150 160 170 180 190 200 pF1KE1 VCPVGWGVRKKGTETEDVRCKQCARGTFSDVPSSVMKCKAYTDCLSQNLVVIKPGTKETD : :.:: . :::: :: :: :: ::::.. ::. :. . : :.:.: ::. : XP_016 KCRPGFGVARPGTETSDVVCKPCAPGTFSNTTSSTDICRPHQIC---NVVAI-PGNASMD 150 160 170 180 190 210 220 230 240 250 260 pF1KE1 NVCGTLPSFSSSTSPSPGTAIFPRP---EHMETHEVPSSTYVPKGMNSTESNSSASVRPK :: : : . : .::.. .:.: . ..:. .: . .: XP_016 AVC---TSTSPTRSMAPGAVHLPQPVSTRSQHTQPTPEPSTAPSTSFLLPMGPSPPAEGS 200 210 220 230 240 250 270 280 290 300 310 320 pF1KE1 VLSSIQEGTVPDNTSSARGKEDVNKTLPNLQVVNHQQGPHHRHILKLLPSMEATGGEKSS XP_016 TGDFALPVGLIVGVTALGLLIIGVVNCVIMTQVKKKPLCLQREAKVVSVSTALSPSSPGL 260 270 280 290 300 310 655 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Mon Nov 7 00:59:48 2016 done: Mon Nov 7 00:59:49 2016 Total Scan time: 12.730 Total Display time: 0.050 Function used was FASTA [36.3.4 Apr, 2011]