Result of FASTA (omim) for
pFN21AB5995
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB5995, 577 aa
1>>>pF1KB5995 577 - 577 aa - 577 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 11.4359+/-0.000535; mu= -4.7854+/- 0.034
mean_var=574.8918+/-121.933, 0's: 0 Z-trim(122.1): 106 B-trim: 1946 in 1/54
Lambda= 0.053491
statistics sampled from 39589 (39711) to 39589 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.761), E-opt: 0.2 (0.466), width: 16
Scan time: 12.940
The best scores are: opt bits E(85289)
NP_001316 (OMIM: 300907) cleavage stimulation fact ( 577) 3935 318.7 3.3e-86
NP_056050 (OMIM: 611968) cleavage stimulation fact ( 616) 2535 210.7 1.1e-53
NP_001293138 (OMIM: 300907) cleavage stimulation f ( 560) 2313 193.5 1.5e-48
NP_001293135 (OMIM: 300907) cleavage stimulation f ( 597) 2299 192.5 3.4e-48
NP_005841 (OMIM: 154400,605593) splicing factor 3B ( 424) 360 42.6 0.003
>>NP_001316 (OMIM: 300907) cleavage stimulation factor s (577 aa)
initn: 3935 init1: 3935 opt: 3935 Z-score: 1668.8 bits: 318.7 E(85289): 3.3e-86
Smith-Waterman score: 3935; 100.0% identity (100.0% similar) in 577 aa overlap (1-577:1-577)
10 20 30 40 50 60
pF1KB5 MAGLTVRDPAVDRSLRSVFVGNIPYEATEEQLKDIFSEVGPVVSFRLVYDRETGKPKGYG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MAGLTVRDPAVDRSLRSVFVGNIPYEATEEQLKDIFSEVGPVVSFRLVYDRETGKPKGYG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB5 FCEYQDQETALSAMRNLNGREFSGRALRVDNAASEKNKEELKSLGTGAPVIESPYGETIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FCEYQDQETALSAMRNLNGREFSGRALRVDNAASEKNKEELKSLGTGAPVIESPYGETIS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB5 PEDAPESISKAVASLPPEQMFELMKQMKLCVQNSPQEARNMLLQNPQLAYALLQAQVVMR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PEDAPESISKAVASLPPEQMFELMKQMKLCVQNSPQEARNMLLQNPQLAYALLQAQVVMR
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB5 IVDPEIALKILHRQTNIPTLIAGNPQPVHGAGPGSGSNVSMNQQNPQAPQAQSLGGMHVN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IVDPEIALKILHRQTNIPTLIAGNPQPVHGAGPGSGSNVSMNQQNPQAPQAQSLGGMHVN
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB5 GAPPLMQASMQGGVPAPGQMPAAVTGPGPGSLAPGGGMQAQVGMPGSGPVSMERGQVPMQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GAPPLMQASMQGGVPAPGQMPAAVTGPGPGSLAPGGGMQAQVGMPGSGPVSMERGQVPMQ
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB5 DPRAAMQRGSLPANVPTPRGLLGDAPNDPRGGTLLSVTGEVEPRGYLGPPHQGPPMHHVP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DPRAAMQRGSLPANVPTPRGLLGDAPNDPRGGTLLSVTGEVEPRGYLGPPHQGPPMHHVP
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB5 GHESRGPPPHELRGGPLPEPRPLMAEPRGPMLDQRGPPLDGRGGRDPRGIDARGMEARAM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GHESRGPPPHELRGGPLPEPRPLMAEPRGPMLDQRGPPLDGRGGRDPRGIDARGMEARAM
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB5 EARGLDARGLEARAMEARAMEARAMEARAMEARAMEVRGMEARGMDTRGPVPGPRGPIPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EARGLDARGLEARAMEARAMEARAMEARAMEARAMEVRGMEARGMDTRGPVPGPRGPIPS
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB5 GMQGPSPINMGAVVPQGSRQVPVMQGTGMQGASIQGGSQPGGFSPGQNQVTPQDHEKAAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GMQGPSPINMGAVVPQGSRQVPVMQGTGMQGASIQGGSQPGGFSPGQNQVTPQDHEKAAL
490 500 510 520 530 540
550 560 570
pF1KB5 IMQVLQLTADQIAMLPPEQRQSILILKEQIQKSTGAP
:::::::::::::::::::::::::::::::::::::
NP_001 IMQVLQLTADQIAMLPPEQRQSILILKEQIQKSTGAP
550 560 570
>>NP_056050 (OMIM: 611968) cleavage stimulation factor s (616 aa)
initn: 1812 init1: 1221 opt: 2535 Z-score: 1084.6 bits: 210.7 E(85289): 1.1e-53
Smith-Waterman score: 2777; 69.4% identity (80.8% similar) in 625 aa overlap (1-570:1-609)
10 20 30 40 50 60
pF1KB5 MAGLTVRDPAVDRSLRSVFVGNIPYEATEEQLKDIFSEVGPVVSFRLVYDRETGKPKGYG
:..:.:::::.::::::::::::::::::::::::::::: :::::::::::::::::::
NP_056 MSSLAVRDPAMDRSLRSVFVGNIPYEATEEQLKDIFSEVGSVVSFRLVYDRETGKPKGYG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB5 FCEYQDQETALSAMRNLNGREFSGRALRVDNAASEKNKEELKSLGTGAPVIESPYGETIS
::::::::::::::::::::::::::::::::::::::::::::: .::.:.::::. :.
NP_056 FCEYQDQETALSAMRNLNGREFSGRALRVDNAASEKNKEELKSLGPAAPIIDSPYGDPID
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB5 PEDAPESISKAVASLPPEQMFELMKQMKLCVQNSPQEARNMLLQNPQLAYALLQAQVVMR
::::::::..:::::::::::::::::::::::: :::::::::::::::::::::::::
NP_056 PEDAPESITRAVASLPPEQMFELMKQMKLCVQNSHQEARNMLLQNPQLAYALLQAQVVMR
130 140 150 160 170 180
190 200 210 220 230
pF1KB5 IVDPEIALKILHRQTNIPTLIAGNPQ------PVHGAGPG--SGSNVSMNQQNPQAPQAQ
:.:::::::::::. .. :: :. : : : ::: : :: .::::: ::: :
NP_056 IMDPEIALKILHRKIHVTPLIPGKSQSVSVSGPGPGPGPGLCPGPNVLLNQQNPPAPQPQ
190 200 210 220 230 240
240 250 260 270 280 290
pF1KB5 SLGGMHVNGAPPLMQASMQGGVPAPGQMPAAVTGPGPGSLAPGGGMQAQVGMPGSGPVSM
:. :. :::::. .:::.:::: .:::: : :::::.:::.:: :.:::: ::: .
NP_056 HLARRPVKDIPPLMQTPIQGGIPAPGPIPAAVPGAGPGSLTPGGAMQPQLGMPGVGPVPL
250 260 270 280 290 300
300 310 320 330 340 350
pF1KB5 ERGQVPMQDPRAAMQRGSL-PANVPTPRGLLGDAPNDPRGGTLLSVTGEVEPRGYLGPPH
::::: :.:::: . :: . :...: ::::::::::::::::::::::::::::::::::
NP_056 ERGQVQMSDPRAPIPRGPVTPGGLP-PRGLLGDAPNDPRGGTLLSVTGEVEPRGYLGPPH
310 320 330 340 350
360 370 380 390 400 410
pF1KB5 QGPPMHHVPGHESRGPPPHELRGGPLPEPRPLMAEPRGPMLDQRGPPLDGRGGRDPRGID
:::::::. ::..::: ::.::::: .:: :..::::::.:::: :.:::::::
NP_056 QGPPMHHASGHDTRGPSSHEMRGGPLGDPRLLIGEPRGPMIDQRGLPMDGRGGRD-----
360 370 380 390 400 410
420 430 440 450 460 470
pF1KB5 ARGMEARAMEARGLDARGLEARAMEARAMEARAMEARAMEARAMEVRGMEARGMDTRGPV
.:.::.::::.. ..:.:.:: :.::. :::.:.::.:::.:::.. ::::
NP_056 SRAMETRAMETE----------VLETRVMERRGMETCAMETRGMEARGMDARGLEMRGPV
420 430 440 450 460
480 490 500 510
pF1KB5 PGPRGPIPSGMQGPSPINMGAV-VPQGSRQVPVM---------------QGTGMQGASIQ
:. :::. .:.:::.:::.:: ::: :::: . ::::::::.::
NP_056 PSSRGPMTGGIQGPGPINIGAGGPPQGPRQVPGISGVGNPGAGMQGTGIQGTGMQGAGIQ
470 480 490 500 510 520
520 530 540
pF1KB5 GG------------------------------SQPGGFSPGQNQVTPQDHEKAALIMQVL
:: :::..:::::.::::::.::::::::::
NP_056 GGGMQGAGIQGVSIQGGGIQGGGIQGASKQGGSQPSSFSPGQSQVTPQDQEKAALIMQVL
530 540 550 560 570 580
550 560 570
pF1KB5 QLTADQIAMLPPEQRQSILILKEQIQKSTGAP
:::::::::::::::::::::::::
NP_056 QLTADQIAMLPPEQRQSILILKEQIQKSTGAS
590 600 610
>>NP_001293138 (OMIM: 300907) cleavage stimulation facto (560 aa)
initn: 2292 init1: 2292 opt: 2313 Z-score: 992.5 bits: 193.5 E(85289): 1.5e-48
Smith-Waterman score: 3770; 97.1% identity (97.1% similar) in 577 aa overlap (1-577:1-560)
10 20 30 40 50 60
pF1KB5 MAGLTVRDPAVDRSLRSVFVGNIPYEATEEQLKDIFSEVGPVVSFRLVYDRETGKPKGYG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MAGLTVRDPAVDRSLRSVFVGNIPYEATEEQLKDIFSEVGPVVSFRLVYDRETGKPKGYG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB5 FCEYQDQETALSAMRNLNGREFSGRALRVDNAASEKNKEELKSLGTGAPVIESPYGETIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FCEYQDQETALSAMRNLNGREFSGRALRVDNAASEKNKEELKSLGTGAPVIESPYGETIS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB5 PEDAPESISKAVASLPPEQMFELMKQMKLCVQNSPQEARNMLLQNPQLAYALLQAQVVMR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PEDAPESISKAVASLPPEQMFELMKQMKLCVQNSPQEARNMLLQNPQLAYALLQAQVVMR
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB5 IVDPEIALKILHRQTNIPTLIAGNPQPVHGAGPGSGSNVSMNQQNPQAPQAQSLGGMHVN
:::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IVDPEIALKILHRQTNIPTLIAGNPQPVHGAGPGSGSNVSMNQQNPQAPQAQSLG-----
190 200 210 220 230
250 260 270 280 290 300
pF1KB5 GAPPLMQASMQGGVPAPGQMPAAVTGPGPGSLAPGGGMQAQVGMPGSGPVSMERGQVPMQ
::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ------------GVPAPGQMPAAVTGPGPGSLAPGGGMQAQVGMPGSGPVSMERGQVPMQ
240 250 260 270 280
310 320 330 340 350 360
pF1KB5 DPRAAMQRGSLPANVPTPRGLLGDAPNDPRGGTLLSVTGEVEPRGYLGPPHQGPPMHHVP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DPRAAMQRGSLPANVPTPRGLLGDAPNDPRGGTLLSVTGEVEPRGYLGPPHQGPPMHHVP
290 300 310 320 330 340
370 380 390 400 410 420
pF1KB5 GHESRGPPPHELRGGPLPEPRPLMAEPRGPMLDQRGPPLDGRGGRDPRGIDARGMEARAM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GHESRGPPPHELRGGPLPEPRPLMAEPRGPMLDQRGPPLDGRGGRDPRGIDARGMEARAM
350 360 370 380 390 400
430 440 450 460 470 480
pF1KB5 EARGLDARGLEARAMEARAMEARAMEARAMEARAMEVRGMEARGMDTRGPVPGPRGPIPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EARGLDARGLEARAMEARAMEARAMEARAMEARAMEVRGMEARGMDTRGPVPGPRGPIPS
410 420 430 440 450 460
490 500 510 520 530 540
pF1KB5 GMQGPSPINMGAVVPQGSRQVPVMQGTGMQGASIQGGSQPGGFSPGQNQVTPQDHEKAAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GMQGPSPINMGAVVPQGSRQVPVMQGTGMQGASIQGGSQPGGFSPGQNQVTPQDHEKAAL
470 480 490 500 510 520
550 560 570
pF1KB5 IMQVLQLTADQIAMLPPEQRQSILILKEQIQKSTGAP
:::::::::::::::::::::::::::::::::::::
NP_001 IMQVLQLTADQIAMLPPEQRQSILILKEQIQKSTGAP
530 540 550 560
>>NP_001293135 (OMIM: 300907) cleavage stimulation facto (597 aa)
initn: 2043 init1: 2043 opt: 2299 Z-score: 986.3 bits: 192.5 E(85289): 3.4e-48
Smith-Waterman score: 3885; 96.6% identity (96.6% similar) in 597 aa overlap (1-577:1-597)
10 20 30 40 50 60
pF1KB5 MAGLTVRDPAVDRSLRSVFVGNIPYEATEEQLKDIFSEVGPVVSFRLVYDRETGKPKGYG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MAGLTVRDPAVDRSLRSVFVGNIPYEATEEQLKDIFSEVGPVVSFRLVYDRETGKPKGYG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB5 FCEYQDQETALSAMRNLNGREFSGRALRVDNAASEKNKEELKSLGTGAPVIESPYGETIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FCEYQDQETALSAMRNLNGREFSGRALRVDNAASEKNKEELKSLGTGAPVIESPYGETIS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB5 PEDAPESISKAVASLPPEQMFELMKQMKLCVQNSPQEARNMLLQNPQLAYALLQAQVVMR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PEDAPESISKAVASLPPEQMFELMKQMKLCVQNSPQEARNMLLQNPQLAYALLQAQVVMR
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB5 IVDPEIALKILHRQTNIPTLIAGNPQPVHGAGPGSGSNVSMNQQNPQAPQAQSLGGMHVN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IVDPEIALKILHRQTNIPTLIAGNPQPVHGAGPGSGSNVSMNQQNPQAPQAQSLGGMHVN
190 200 210 220 230 240
250 260 270 280 290
pF1KB5 GAPPLMQASMQGGVPAPGQMPAAVTGPGPGSLAPGGGMQAQVGMPGSGPVSMERGQ----
::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GAPPLMQASMQGGVPAPGQMPAAVTGPGPGSLAPGGGMQAQVGMPGSGPVSMERGQGTLQ
250 260 270 280 290 300
300 310 320 330 340
pF1KB5 ----------------VPMQDPRAAMQRGSLPANVPTPRGLLGDAPNDPRGGTLLSVTGE
::::::::::::::::::::::::::::::::::::::::::::
NP_001 HSPVGPAGPASIERVQVPMQDPRAAMQRGSLPANVPTPRGLLGDAPNDPRGGTLLSVTGE
310 320 330 340 350 360
350 360 370 380 390 400
pF1KB5 VEPRGYLGPPHQGPPMHHVPGHESRGPPPHELRGGPLPEPRPLMAEPRGPMLDQRGPPLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VEPRGYLGPPHQGPPMHHVPGHESRGPPPHELRGGPLPEPRPLMAEPRGPMLDQRGPPLD
370 380 390 400 410 420
410 420 430 440 450 460
pF1KB5 GRGGRDPRGIDARGMEARAMEARGLDARGLEARAMEARAMEARAMEARAMEARAMEVRGM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GRGGRDPRGIDARGMEARAMEARGLDARGLEARAMEARAMEARAMEARAMEARAMEVRGM
430 440 450 460 470 480
470 480 490 500 510 520
pF1KB5 EARGMDTRGPVPGPRGPIPSGMQGPSPINMGAVVPQGSRQVPVMQGTGMQGASIQGGSQP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EARGMDTRGPVPGPRGPIPSGMQGPSPINMGAVVPQGSRQVPVMQGTGMQGASIQGGSQP
490 500 510 520 530 540
530 540 550 560 570
pF1KB5 GGFSPGQNQVTPQDHEKAALIMQVLQLTADQIAMLPPEQRQSILILKEQIQKSTGAP
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GGFSPGQNQVTPQDHEKAALIMQVLQLTADQIAMLPPEQRQSILILKEQIQKSTGAP
550 560 570 580 590
>>NP_005841 (OMIM: 154400,605593) splicing factor 3B sub (424 aa)
initn: 284 init1: 182 opt: 360 Z-score: 179.2 bits: 42.6 E(85289): 0.003
Smith-Waterman score: 402; 27.4% identity (48.3% similar) in 435 aa overlap (9-397:5-421)
10 20 30 40 50
pF1KB5 MAGLTVRDPAVDRSLR-SVFVGNIPYEATEEQLKDIFSEVGPVVSFRLVYDRETGKPKGY
: .:. .:.::.. ...: : ..: ..::::. .. :: ::. .::
NP_005 MAAGPISERNQDATVYVGGLDEKVSEPLLWELFLQAGPVVNTHMPKDRVTGQHQGY
10 20 30 40 50
60 70 80 90 100 110
pF1KB5 GFCEYQDQETALSAMRNLNGREFSGRALRVDNAASEKNKEELKS---LGTGAPVIE----
:: :. ..: : :.. .: .. :. .::..:...... .. . .:. : :.
NP_005 GFVEFLSEEDADYAIKIMNMIKLYGKPIRVNKASAHNKNLDVGANIFIGNLDPEIDEKLL
60 70 80 90 100 110
120 130 140 150
pF1KB5 ----SPYGETI-SPE---DAPESISKAVASL------PPEQMFELMKQMKLCVQNSPQEA
: .: . .:. : . ::. : . . .: :. . :: : : .
NP_005 YDTFSAFGVILQTPKIMRDPDTGNSKGYAFINFASFDASDAAIEAMNGQYLC--NRPITV
120 130 140 150 160 170
160 170 180 190 200 210
pF1KB5 RNMLLQNPQLAYALLQAQVVMRIVDPEIALKILHRQTNIPTLIAGNPQPV---HGAG-PG
. .. . :. .. .: :. . :.:: :.: :
NP_005 SYAFKKDSKGERHGSAAERLLAAQNPLSQADRPHQLFADAPPPPSAPNPVVSSLGSGLPP
180 190 200 210 220 230
220 230 240 250 260 270
pF1KB5 SGSNVSMNQQNPQAPQAQSLGGMHVNGAPPLMQASMQG-GVPAPGQMPAAVTGPG---PG
: . : : . :. :: : . : : :. : :. : : :
NP_005 PGMPPPGSFPPPVPPPGALPPGIPPAMPPPPMPPGAAGHGPPSAGTPGAGHPGHGHSHPH
240 250 260 270 280 290
280 290 300 310
pF1KB5 SLAPGG----GM-QAQV--------GMPGSGPVSMERGQVPMQDPRAAMQRGSLPANVPT
. ::: :: : :. : : .:: . :: : . : . . : : ..:
NP_005 PFPPGGMPHPGMSQMQLAHHGPHGLGHPHAGPPG-SGGQPPPRPPPGMPHPGPPPMGMP-
300 310 320 330 340 350
320 330 340 350 360 370
pF1KB5 PRGLLGDAPNDPRGGTLLSVTGEVEPRGYLGPPHQGPPMHHVPGHESRGPPPHELRGGPL
::: : :. .. : . :.:. ::: :: : : :::. . :::
NP_005 PRG--------PPFGSPMGHPGPMPPHGMRGPPPLMPP-HGYTGPPR--PPPYGYQRGPL
360 370 380 390 400
380 390 400 410 420 430
pF1KB5 PEPRPLM---AEPRGPMLDQRGPPLDGRGGRDPRGIDARGMEARAMEARGLDARGLEARA
: ::: . ::::. :::
NP_005 PPPRPTPRPPVPPRGPL---RGPLPQ
410 420
577 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sat Nov 5 10:52:53 2016 done: Sat Nov 5 10:52:54 2016
Total Scan time: 12.940 Total Display time: 0.060
Function used was FASTA [36.3.4 Apr, 2011]