FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE2233, 662 aa 1>>>pF1KE2233 662 - 662 aa - 662 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.9955+/-0.000357; mu= 17.0200+/- 0.023 mean_var=86.4676+/-17.395, 0's: 0 Z-trim(115.2): 32 B-trim: 230 in 1/56 Lambda= 0.137926 statistics sampled from 25467 (25490) to 25467 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.656), E-opt: 0.2 (0.299), width: 16 Scan time: 8.220 The best scores are: opt bits E(85289) NP_009133 (OMIM: 115080,604694) A-kinase anchor pr ( 662) 4333 872.4 0 XP_016879560 (OMIM: 115080,604694) PREDICTED: A-ki ( 644) 3998 805.7 0 NP_001317081 (OMIM: 115080,604694) A-kinase anchor ( 604) 3207 648.3 2.4e-185 >>NP_009133 (OMIM: 115080,604694) A-kinase anchor protei (662 aa) initn: 4333 init1: 4333 opt: 4333 Z-score: 4659.0 bits: 872.4 E(85289): 0 Smith-Waterman score: 4333; 100.0% identity (100.0% similar) in 662 aa overlap (1-662:1-662) 10 20 30 40 50 60 pF1KE2 MRGAGPSPRQSPRTLRPDPGPAMSFFRRKVKGKEQEKTSDVKSIKASISVHSPQKSTKNH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_009 MRGAGPSPRQSPRTLRPDPGPAMSFFRRKVKGKEQEKTSDVKSIKASISVHSPQKSTKNH 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 ALLEAAGPSHVAINAISANMDSFSSSRTATLKKQPSHMEAAHFGDLGRSCLDYQTQETKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_009 ALLEAAGPSHVAINAISANMDSFSSSRTATLKKQPSHMEAAHFGDLGRSCLDYQTQETKS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 SLSKTLEQVLHDTIVLPYFIQFMELRRMEHLVKFWLEAESFHSTTWSRIRAHSLNTVKQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_009 SLSKTLEQVLHDTIVLPYFIQFMELRRMEHLVKFWLEAESFHSTTWSRIRAHSLNTVKQS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 SLAEPVSPSKKHETTASFLTDSLDKRLEDSGSAQLFMTHSEGIDLNNRTNSTQNHLLLSQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_009 SLAEPVSPSKKHETTASFLTDSLDKRLEDSGSAQLFMTHSEGIDLNNRTNSTQNHLLLSQ 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 ECDSAHSLRLEMARAGTHQVSMETQESSSTLTVASRNSPASPLKELSGKLMKSIEQDAVN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_009 ECDSAHSLRLEMARAGTHQVSMETQESSSTLTVASRNSPASPLKELSGKLMKSIEQDAVN 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 TFTKYISPDAAKPIPITEAMRNDIIARICGEDGQVDPNCFVLAQSIVFSAMEQEHFSEFL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_009 TFTKYISPDAAKPIPITEAMRNDIIARICGEDGQVDPNCFVLAQSIVFSAMEQEHFSEFL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 RSHHFCKYQIEVLTSGTVYLADILFCESALFYFSEYMEKEDAVNILQFWLAADNFQSQLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_009 RSHHFCKYQIEVLTSGTVYLADILFCESALFYFSEYMEKEDAVNILQFWLAADNFQSQLA 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE2 AKKGQYDGQEAQNDAMILYDKYFSLQATHPLGFDDVVRLEIESNICREGGPLPNCFTTPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_009 AKKGQYDGQEAQNDAMILYDKYFSLQATHPLGFDDVVRLEIESNICREGGPLPNCFTTPL 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE2 RQAWTTMEKVFLPGFLSSNLYYKYLNDLIHSVRGDEFLGGNVSLTAPGSVGPPDESHPGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_009 RQAWTTMEKVFLPGFLSSNLYYKYLNDLIHSVRGDEFLGGNVSLTAPGSVGPPDESHPGS 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE2 SDSSASQSSVKKASIKILKNFDEAIIVDAASLDPESLYQRTYAGKMTFGRVSDLGQFIRE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_009 SDSSASQSSVKKASIKILKNFDEAIIVDAASLDPESLYQRTYAGKMTFGRVSDLGQFIRE 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE2 SEPEPDVRKSKGSMFSQAMKKWVQGNTDEAQEELAWKIAKMIVSDIMQQAQYDQPLEKST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_009 SEPEPDVRKSKGSMFSQAMKKWVQGNTDEAQEELAWKIAKMIVSDIMQQAQYDQPLEKST 610 620 630 640 650 660 pF1KE2 KL :: NP_009 KL >>XP_016879560 (OMIM: 115080,604694) PREDICTED: A-kinase (644 aa) initn: 3998 init1: 3998 opt: 3998 Z-score: 4298.9 bits: 805.7 E(85289): 0 Smith-Waterman score: 3998; 100.0% identity (100.0% similar) in 611 aa overlap (1-611:1-611) 10 20 30 40 50 60 pF1KE2 MRGAGPSPRQSPRTLRPDPGPAMSFFRRKVKGKEQEKTSDVKSIKASISVHSPQKSTKNH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MRGAGPSPRQSPRTLRPDPGPAMSFFRRKVKGKEQEKTSDVKSIKASISVHSPQKSTKNH 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 ALLEAAGPSHVAINAISANMDSFSSSRTATLKKQPSHMEAAHFGDLGRSCLDYQTQETKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ALLEAAGPSHVAINAISANMDSFSSSRTATLKKQPSHMEAAHFGDLGRSCLDYQTQETKS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 SLSKTLEQVLHDTIVLPYFIQFMELRRMEHLVKFWLEAESFHSTTWSRIRAHSLNTVKQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SLSKTLEQVLHDTIVLPYFIQFMELRRMEHLVKFWLEAESFHSTTWSRIRAHSLNTVKQS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 SLAEPVSPSKKHETTASFLTDSLDKRLEDSGSAQLFMTHSEGIDLNNRTNSTQNHLLLSQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SLAEPVSPSKKHETTASFLTDSLDKRLEDSGSAQLFMTHSEGIDLNNRTNSTQNHLLLSQ 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 ECDSAHSLRLEMARAGTHQVSMETQESSSTLTVASRNSPASPLKELSGKLMKSIEQDAVN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ECDSAHSLRLEMARAGTHQVSMETQESSSTLTVASRNSPASPLKELSGKLMKSIEQDAVN 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 TFTKYISPDAAKPIPITEAMRNDIIARICGEDGQVDPNCFVLAQSIVFSAMEQEHFSEFL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TFTKYISPDAAKPIPITEAMRNDIIARICGEDGQVDPNCFVLAQSIVFSAMEQEHFSEFL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 RSHHFCKYQIEVLTSGTVYLADILFCESALFYFSEYMEKEDAVNILQFWLAADNFQSQLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RSHHFCKYQIEVLTSGTVYLADILFCESALFYFSEYMEKEDAVNILQFWLAADNFQSQLA 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE2 AKKGQYDGQEAQNDAMILYDKYFSLQATHPLGFDDVVRLEIESNICREGGPLPNCFTTPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AKKGQYDGQEAQNDAMILYDKYFSLQATHPLGFDDVVRLEIESNICREGGPLPNCFTTPL 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE2 RQAWTTMEKVFLPGFLSSNLYYKYLNDLIHSVRGDEFLGGNVSLTAPGSVGPPDESHPGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RQAWTTMEKVFLPGFLSSNLYYKYLNDLIHSVRGDEFLGGNVSLTAPGSVGPPDESHPGS 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE2 SDSSASQSSVKKASIKILKNFDEAIIVDAASLDPESLYQRTYAGKMTFGRVSDLGQFIRE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SDSSASQSSVKKASIKILKNFDEAIIVDAASLDPESLYQRTYAGKMTFGRVSDLGQFIRE 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE2 SEPEPDVRKSKGSMFSQAMKKWVQGNTDEAQEELAWKIAKMIVSDIMQQAQYDQPLEKST ::::::::::: XP_016 SEPEPDVRKSKVLALSPRPECSGLTAPHCNLCFLGSSDFPASSS 610 620 630 640 >>NP_001317081 (OMIM: 115080,604694) A-kinase anchor pro (604 aa) initn: 3207 init1: 3207 opt: 3207 Z-score: 3448.7 bits: 648.3 E(85289): 2.4e-185 Smith-Waterman score: 3818; 91.2% identity (91.2% similar) in 662 aa overlap (1-662:1-604) 10 20 30 40 50 60 pF1KE2 MRGAGPSPRQSPRTLRPDPGPAMSFFRRKVKGKEQEKTSDVKSIKASISVHSPQKSTKNH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MRGAGPSPRQSPRTLRPDPGPAMSFFRRKVKGKEQEKTSDVKSIKASISVHSPQKSTKNH 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 ALLEAAGPSHVAINAISANMDSFSSSRTATLKKQPSHMEAAHFGDLGRSCLDYQTQETKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ALLEAAGPSHVAINAISANMDSFSSSRTATLKKQPSHMEAAHFGDLGRSCLDYQTQETKS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 SLSKTLEQVLHDTIVLPYFIQFMELRRMEHLVKFWLEAESFHSTTWSRIRAHSLNTVKQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SLSKTLEQVLHDTIVLPYFIQFMELRRMEHLVKFWLEAESFHSTTWSRIRAHSLNTVKQS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 SLAEPVSPSKKHETTASFLTDSLDKRLEDSGSAQLFMTHSEGIDLNNRTNSTQNHLLLSQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SLAEPVSPSKKHETTASFLTDSLDKRLEDSGSAQLFMTHSEGIDLNNRTNSTQNHLLLSQ 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 ECDSAHSLRLEMARAGTHQVSMETQESSSTLTVASRNSPASPLKELSGKLMKSIEQDAVN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ECDSAHSLRLEMARAGTHQVSMETQESSSTLTVASRNSPASPLKELSGKLMKSIEQDAVN 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 TFTKYISPDAAKPIPITEAMRNDIIARICGEDGQVDPNCFVLAQSIVFSAMEQEHFSEFL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TFTKYISPDAAKPIPITEAMRNDIIARICGEDGQVDPNCFVLAQSIVFSAMEQEHFSEFL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 RSHHFCKYQIEVLTSGTVYLADILFCESALFYFSEYMEKEDAVNILQFWLAADNFQSQLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RSHHFCKYQIEVLTSGTVYLADILFCESALFYFSEYMEKEDAVNILQFWLAADNFQSQLA 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE2 AKKGQYDGQEAQNDAMILYDKYFSLQATHPLGFDDVVRLEIESNICREGGPLPNCFTTPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AKKGQYDGQEAQNDAMILYDKYFSLQATHPLGFDDVVRLEIESNICREGGPLPNCFTTPL 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE2 RQAWTTMEKVFLPGFLSSNLYYKYLNDLIHSVRGDEFLGGNVSLTAPGSVGPPDESHPGS ::::::::: NP_001 RQAWTTMEK--------------------------------------------------- 550 560 570 580 590 600 pF1KE2 SDSSASQSSVKKASIKILKNFDEAIIVDAASLDPESLYQRTYAGKMTFGRVSDLGQFIRE ::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 -------SSVKKASIKILKNFDEAIIVDAASLDPESLYQRTYAGKMTFGRVSDLGQFIRE 490 500 510 520 530 540 610 620 630 640 650 660 pF1KE2 SEPEPDVRKSKGSMFSQAMKKWVQGNTDEAQEELAWKIAKMIVSDIMQQAQYDQPLEKST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SEPEPDVRKSKGSMFSQAMKKWVQGNTDEAQEELAWKIAKMIVSDIMQQAQYDQPLEKST 550 560 570 580 590 600 pF1KE2 KL :: NP_001 KL 662 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Mon Nov 7 01:06:20 2016 done: Mon Nov 7 01:06:21 2016 Total Scan time: 8.220 Total Display time: 0.040 Function used was FASTA [36.3.4 Apr, 2011]