Result of FASTA (omim) for
pFN21AB6928
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB6928, 227 aa
1>>>pF1KB6928 227 - 227 aa - 227 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.1417+/-0.000338; mu= 15.3312+/- 0.021
mean_var=71.9659+/-14.311, 0's: 0 Z-trim(115.0): 35 B-trim: 9 in 1/50
Lambda= 0.151186
statistics sampled from 25074 (25109) to 25074 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.692), E-opt: 0.2 (0.294), width: 16
Scan time: 6.630
The best scores are: opt bits E(85289)
NP_001157030 (OMIM: 176760) prolactin precursor [H ( 227) 1513 338.8 4.4e-93
NP_000939 (OMIM: 176760) prolactin precursor [Homo ( 227) 1513 338.8 4.4e-93
XP_011513056 (OMIM: 176760) PREDICTED: prolactin i ( 228) 1501 336.2 2.7e-92
XP_011513055 (OMIM: 176760) PREDICTED: prolactin i ( 228) 1501 336.2 2.7e-92
NP_000506 (OMIM: 139250,173100,262400,262650,61278 ( 217) 270 67.7 1.8e-11
NP_001308 (OMIM: 150200) chorionic somatomammotrop ( 217) 249 63.1 4.2e-10
NP_066271 (OMIM: 118820) chorionic somatomammotrop ( 217) 249 63.1 4.2e-10
NP_002050 (OMIM: 139240) growth hormone variant is ( 217) 227 58.3 1.2e-08
NP_072101 (OMIM: 603515) chorionic somatomammotrop ( 222) 190 50.3 3.2e-06
NP_072170 (OMIM: 118820) chorionic somatomammotrop ( 167) 177 47.3 1.8e-05
NP_072050 (OMIM: 139240) growth hormone variant is ( 202) 169 45.6 7.1e-05
NP_072052 (OMIM: 139240) growth hormone variant is ( 245) 154 42.4 0.0008
NP_072051 (OMIM: 139240) growth hormone variant is ( 256) 150 41.6 0.0015
NP_001307996 (OMIM: 603515) chorionic somatomammot ( 162) 142 39.7 0.0035
NP_001307998 (OMIM: 603515) chorionic somatomammot ( 183) 139 39.1 0.0061
>>NP_001157030 (OMIM: 176760) prolactin precursor [Homo (227 aa)
initn: 1513 init1: 1513 opt: 1513 Z-score: 1792.1 bits: 338.8 E(85289): 4.4e-93
Smith-Waterman score: 1513; 100.0% identity (100.0% similar) in 227 aa overlap (1-227:1-227)
10 20 30 40 50 60
pF1KB6 MNIKGSPWKGSLLLLLVSNLLLCQSVAPLPICPGGAARCQVTLRDLFDRAVVLSHYIHNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MNIKGSPWKGSLLLLLVSNLLLCQSVAPLPICPGGAARCQVTLRDLFDRAVVLSHYIHNL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB6 SSEMFSEFDKRYTHGRGFITKAINSCHTSSLATPEDKEQAQQMNQKDFLSLIVSILRSWN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SSEMFSEFDKRYTHGRGFITKAINSCHTSSLATPEDKEQAQQMNQKDFLSLIVSILRSWN
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB6 EPLYHLVTEVRGMQEAPEAILSKAVEIEEQTKRLLEGMELIVSQVHPETKENEIYPVWSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EPLYHLVTEVRGMQEAPEAILSKAVEIEEQTKRLLEGMELIVSQVHPETKENEIYPVWSG
130 140 150 160 170 180
190 200 210 220
pF1KB6 LPSLQMADEESRLSAYYNLLHCLRRDSHKIDNYLKLLKCRIIHNNNC
:::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LPSLQMADEESRLSAYYNLLHCLRRDSHKIDNYLKLLKCRIIHNNNC
190 200 210 220
>>NP_000939 (OMIM: 176760) prolactin precursor [Homo sap (227 aa)
initn: 1513 init1: 1513 opt: 1513 Z-score: 1792.1 bits: 338.8 E(85289): 4.4e-93
Smith-Waterman score: 1513; 100.0% identity (100.0% similar) in 227 aa overlap (1-227:1-227)
10 20 30 40 50 60
pF1KB6 MNIKGSPWKGSLLLLLVSNLLLCQSVAPLPICPGGAARCQVTLRDLFDRAVVLSHYIHNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 MNIKGSPWKGSLLLLLVSNLLLCQSVAPLPICPGGAARCQVTLRDLFDRAVVLSHYIHNL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB6 SSEMFSEFDKRYTHGRGFITKAINSCHTSSLATPEDKEQAQQMNQKDFLSLIVSILRSWN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 SSEMFSEFDKRYTHGRGFITKAINSCHTSSLATPEDKEQAQQMNQKDFLSLIVSILRSWN
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB6 EPLYHLVTEVRGMQEAPEAILSKAVEIEEQTKRLLEGMELIVSQVHPETKENEIYPVWSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 EPLYHLVTEVRGMQEAPEAILSKAVEIEEQTKRLLEGMELIVSQVHPETKENEIYPVWSG
130 140 150 160 170 180
190 200 210 220
pF1KB6 LPSLQMADEESRLSAYYNLLHCLRRDSHKIDNYLKLLKCRIIHNNNC
:::::::::::::::::::::::::::::::::::::::::::::::
NP_000 LPSLQMADEESRLSAYYNLLHCLRRDSHKIDNYLKLLKCRIIHNNNC
190 200 210 220
>>XP_011513056 (OMIM: 176760) PREDICTED: prolactin isofo (228 aa)
initn: 1444 init1: 1444 opt: 1501 Z-score: 1777.9 bits: 336.2 E(85289): 2.7e-92
Smith-Waterman score: 1501; 99.6% identity (99.6% similar) in 228 aa overlap (1-227:1-228)
10 20 30 40 50
pF1KB6 MNIKGSPWK-GSLLLLLVSNLLLCQSVAPLPICPGGAARCQVTLRDLFDRAVVLSHYIHN
::::::::: ::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MNIKGSPWKAGSLLLLLVSNLLLCQSVAPLPICPGGAARCQVTLRDLFDRAVVLSHYIHN
10 20 30 40 50 60
60 70 80 90 100 110
pF1KB6 LSSEMFSEFDKRYTHGRGFITKAINSCHTSSLATPEDKEQAQQMNQKDFLSLIVSILRSW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LSSEMFSEFDKRYTHGRGFITKAINSCHTSSLATPEDKEQAQQMNQKDFLSLIVSILRSW
70 80 90 100 110 120
120 130 140 150 160 170
pF1KB6 NEPLYHLVTEVRGMQEAPEAILSKAVEIEEQTKRLLEGMELIVSQVHPETKENEIYPVWS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NEPLYHLVTEVRGMQEAPEAILSKAVEIEEQTKRLLEGMELIVSQVHPETKENEIYPVWS
130 140 150 160 170 180
180 190 200 210 220
pF1KB6 GLPSLQMADEESRLSAYYNLLHCLRRDSHKIDNYLKLLKCRIIHNNNC
::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GLPSLQMADEESRLSAYYNLLHCLRRDSHKIDNYLKLLKCRIIHNNNC
190 200 210 220
>>XP_011513055 (OMIM: 176760) PREDICTED: prolactin isofo (228 aa)
initn: 1444 init1: 1444 opt: 1501 Z-score: 1777.9 bits: 336.2 E(85289): 2.7e-92
Smith-Waterman score: 1501; 99.6% identity (99.6% similar) in 228 aa overlap (1-227:1-228)
10 20 30 40 50
pF1KB6 MNIKGSPWK-GSLLLLLVSNLLLCQSVAPLPICPGGAARCQVTLRDLFDRAVVLSHYIHN
::::::::: ::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MNIKGSPWKAGSLLLLLVSNLLLCQSVAPLPICPGGAARCQVTLRDLFDRAVVLSHYIHN
10 20 30 40 50 60
60 70 80 90 100 110
pF1KB6 LSSEMFSEFDKRYTHGRGFITKAINSCHTSSLATPEDKEQAQQMNQKDFLSLIVSILRSW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LSSEMFSEFDKRYTHGRGFITKAINSCHTSSLATPEDKEQAQQMNQKDFLSLIVSILRSW
70 80 90 100 110 120
120 130 140 150 160 170
pF1KB6 NEPLYHLVTEVRGMQEAPEAILSKAVEIEEQTKRLLEGMELIVSQVHPETKENEIYPVWS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NEPLYHLVTEVRGMQEAPEAILSKAVEIEEQTKRLLEGMELIVSQVHPETKENEIYPVWS
130 140 150 160 170 180
180 190 200 210 220
pF1KB6 GLPSLQMADEESRLSAYYNLLHCLRRDSHKIDNYLKLLKCRIIHNNNC
::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GLPSLQMADEESRLSAYYNLLHCLRRDSHKIDNYLKLLKCRIIHNNNC
190 200 210 220
>>NP_000506 (OMIM: 139250,173100,262400,262650,612781) s (217 aa)
initn: 186 init1: 102 opt: 270 Z-score: 327.1 bits: 67.7 E(85289): 1.8e-11
Smith-Waterman score: 270; 25.4% identity (60.7% similar) in 224 aa overlap (10-227:4-215)
10 20 30 40 50 60
pF1KB6 MNIKGSPWKGSLLLLLVSNLLLCQSVAPLPICPGGAARCQVTLRDLFDRAVVLSHYIHNL
:: ::.. ::: :: :.: . : ::: :.. .: .:.:
NP_000 MATGSRTSLLLAFGLLC-----LPWLQEGSAFPTIPLSRLFDNAMLRAHRLHQL
10 20 30 40
70 80 90 100 110
pF1KB6 SSEMFSEFDKRYT---HGRGFITKAINS-CHTSSLATPEDKEQAQQMNQKDFLSLIVSIL
. . ..::.. : . .:. . .: : . :. :: ..:..:: .. ..: . . ..
NP_000 AFDTYQEFEEAYIPKEQKYSFLQNPQTSLCFSESIPTPSNREETQQKSNLELLRISLLLI
50 60 70 80 90 100
120 130 140 150 160 170
pF1KB6 RSWNEPLYHLVTEVRGMQEAPEAILSKAVEIEEQTKRLLEGMELIVSQVHPET-KENEIY
.:: ::. : :.. . .. .. . : : ::.. ...... . . ..:.
NP_000 QSWLEPVQFL----RSVFANSLVYGASDSNVYDLLKDLEEGIQTLMGRLEDGSPRTGQIF
110 120 130 140 150 160
180 190 200 210 220
pF1KB6 P-VWSGLPSLQMADEESRLSAYYNLLHCLRRDSHKIDNYLKLLKCRIIHNNNC
..: . . . :. : :.::.:.:.: :....:....:: .... :
NP_000 KQTYSKFDTNSHNDDA--LLKNYGLLYCFRKDMDKVETFLRIVQCRSVEGS-CGF
170 180 190 200 210
>>NP_001308 (OMIM: 150200) chorionic somatomammotropin h (217 aa)
initn: 174 init1: 96 opt: 249 Z-score: 302.4 bits: 63.1 E(85289): 4.2e-10
Smith-Waterman score: 249; 25.0% identity (60.3% similar) in 224 aa overlap (10-227:4-215)
10 20 30 40 50 60
pF1KB6 MNIKGSPWKGSLLLLLVSNLLLCQSVAPLPICPGGAARCQVTLRDLFDRAVVLSHYIHNL
:: ::.. ::: :: ..: : : :::.:.. .: :.:
NP_001 MAPGSRTSLLLAFALLC-----LPWLQEAGAVQTVPLSRLFDHAMLQAHRAHQL
10 20 30 40
70 80 90 100 110
pF1KB6 SSEMFSEFDKRYT---HGRGFITKAINS-CHTSSLATPEDKEQAQQMNQKDFLSLIVSIL
. . ..::.. : . .:. . .: : ..:. :: . :..:: .. ..: . . ..
NP_001 AIDTYQEFEETYIPKDQKYSFLHDSQTSFCFSDSIPTPSNMEETQQKSNLELLRISLLLI
50 60 70 80 90 100
120 130 140 150 160 170
pF1KB6 RSWNEPLYHLVTEVRGMQEAPEAILSKAVEIEEQTKRLLEGMELIVSQVHPETKENE--I
.:: ::. : :.: . .. . . : : ::.. ...... .... .
NP_001 ESWLEPVRFL----RSMFANNLVYDTSDSDDYHLLKDLEEGIQTLMGRLEDGSRRTGQIL
110 120 130 140 150 160
180 190 200 210 220
pF1KB6 YPVWSGLPSLQMADEESRLSAYYNLLHCLRRDSHKIDNYLKLLKCRIIHNNNC
..: . . . ... : :.::.:.:.: :....:....:: .... :
NP_001 KQTYSKFDT--NSHNHDALLKNYGLLYCFRKDMDKVETFLRMVQCRSVEGS-CGF
170 180 190 200 210
>>NP_066271 (OMIM: 118820) chorionic somatomammotropin h (217 aa)
initn: 174 init1: 96 opt: 249 Z-score: 302.4 bits: 63.1 E(85289): 4.2e-10
Smith-Waterman score: 249; 25.0% identity (60.3% similar) in 224 aa overlap (10-227:4-215)
10 20 30 40 50 60
pF1KB6 MNIKGSPWKGSLLLLLVSNLLLCQSVAPLPICPGGAARCQVTLRDLFDRAVVLSHYIHNL
:: ::.. ::: :: ..: : : :::.:.. .: :.:
NP_066 MAAGSRTSLLLAFALLC-----LPWLQEAGAVQTVPLSRLFDHAMLQAHRAHQL
10 20 30 40
70 80 90 100 110
pF1KB6 SSEMFSEFDKRYT---HGRGFITKAINS-CHTSSLATPEDKEQAQQMNQKDFLSLIVSIL
. . ..::.. : . .:. . .: : ..:. :: . :..:: .. ..: . . ..
NP_066 AIDTYQEFEETYIPKDQKYSFLHDSQTSFCFSDSIPTPSNMEETQQKSNLELLRISLLLI
50 60 70 80 90 100
120 130 140 150 160 170
pF1KB6 RSWNEPLYHLVTEVRGMQEAPEAILSKAVEIEEQTKRLLEGMELIVSQVHPETKENE--I
.:: ::. : :.: . .. . . : : ::.. ...... .... .
NP_066 ESWLEPVRFL----RSMFANNLVYDTSDSDDYHLLKDLEEGIQTLMGRLEDGSRRTGQIL
110 120 130 140 150 160
180 190 200 210 220
pF1KB6 YPVWSGLPSLQMADEESRLSAYYNLLHCLRRDSHKIDNYLKLLKCRIIHNNNC
..: . . . ... : :.::.:.:.: :....:....:: .... :
NP_066 KQTYSKFDT--NSHNHDALLKNYGLLYCFRKDMDKVETFLRMVQCRSVEGS-CGF
170 180 190 200 210
>>NP_002050 (OMIM: 139240) growth hormone variant isofor (217 aa)
initn: 150 init1: 71 opt: 227 Z-score: 276.4 bits: 58.3 E(85289): 1.2e-08
Smith-Waterman score: 227; 23.7% identity (59.4% similar) in 224 aa overlap (10-227:4-215)
10 20 30 40 50 60
pF1KB6 MNIKGSPWKGSLLLLLVSNLLLCQSVAPLPICPGGAARCQVTLRDLFDRAVVLSHYIHNL
:: ::.. ::: : :.: . : ::: :.. .. ...:
NP_002 MAAGSRTSLLLAFGLLC-----LSWLQEGSAFPTIPLSRLFDNAMLRARRLYQL
10 20 30 40
70 80 90 100 110
pF1KB6 SSEMFSEFDKRYT---HGRGFITKAINS-CHTSSLATPEDKEQAQQMNQKDFLSLIVSIL
. . ..::.. : . .:. . .: : . :. :: .. ..:: .. ..: . . ..
NP_002 AYDTYQEFEEAYILKEQKYSFLQNPQTSLCFSESIPTPSNRVKTQQKSNLELLRISLLLI
50 60 70 80 90 100
120 130 140 150 160 170
pF1KB6 RSWNEPLYHLVTEVRGMQEAPEAILSKAVEIEEQTKRLLEGMELIVSQVHPET-KENEIY
.:: ::. : :.. . .. .. .. : : ::.. .. ... . . ..:.
NP_002 QSWLEPVQLL----RSVFANSLVYGASDSNVYRHLKDLEEGIQTLMWRLEDGSPRTGQIF
110 120 130 140 150 160
180 190 200 210 220
pF1KB6 -PVWSGLPSLQMADEESRLSAYYNLLHCLRRDSHKIDNYLKLLKCRIIHNNNC
.: . . . :. : :.::.:.:.: :....:....:: .... :
NP_002 NQSYSKFDTKSHNDDA--LLKNYGLLYCFRKDMDKVETFLRIVQCRSVEGS-CGF
170 180 190 200 210
>>NP_072101 (OMIM: 603515) chorionic somatomammotropin h (222 aa)
initn: 197 init1: 101 opt: 190 Z-score: 232.7 bits: 50.3 E(85289): 3.2e-06
Smith-Waterman score: 190; 23.0% identity (56.5% similar) in 230 aa overlap (10-227:4-220)
10 20 30 40 50 60
pF1KB6 MNIKGSPWKGSLLLLLVSNLLLCQSVAPLPICPGGAARCQVTLRDLFDRAVVLSHYIHNL
:: ::.. ::: :: ..: : : :: .:.. .: :.:
NP_072 MAAGSRTSLLLAFALLC-----LPWLQEAGAVQTVPLSRLFKEAMLQAHRAHQL
10 20 30 40
70 80 90 100 110
pF1KB6 SSEMFSEFDKRYTHGRGFITKA----------INSCHTSSLATPEDKEQAQQMNQKDFLS
. . ..:: . . ...::: . : ..:. : . :..:: .. ..:
NP_072 AIDTYQEFISSWGM-EAYITKEQKYSFLHDSQTSFCFSDSIPTSSNMEETQQKSNLELLH
50 60 70 80 90 100
120 130 140 150 160 170
pF1KB6 LIVSILRSWNEPLYHLVTEVRGMQEAPEAILSKAVEIEEQTKRLLEGMELIVSQVHPETK
. . ...: ::. : :. . .. . . : : ::......... ..
NP_072 ISLLLIESRLEPVRFL----RSTFTNNLVYDTSDSDDYHLLKDLEEGIQMLMGRLEDGSH
110 120 130 140 150 160
180 190 200 210 220
pF1KB6 EN--EIYPVWSGLPSLQMADEESRLSAYYNLLHCLRRDSHKIDNYLKLLKCRIIHNNNC
. . ..: . . . ... : :.::::.:.: :....:....:: .... :
NP_072 LTGQTLKQTYSKFDT--NSHNHDALLKNYGLLHCFRKDMDKVETFLRMVQCRSVEGS-CG
170 180 190 200 210 220
NP_072 F
>>NP_072170 (OMIM: 118820) chorionic somatomammotropin h (167 aa)
initn: 176 init1: 93 opt: 177 Z-score: 219.1 bits: 47.3 E(85289): 1.8e-05
Smith-Waterman score: 177; 30.6% identity (60.3% similar) in 121 aa overlap (10-126:4-119)
10 20 30 40 50 60
pF1KB6 MNIKGSPWKGSLLLLLVSNLLLCQSVAPLPICPGGAARCQVTLRDLFDRAVVLSHYIHNL
:: ::.. ::: :: ..: : : :::.:.. .: :.:
NP_072 MAAGSRTSLLLAFALLC-----LPWLQEAGAVQTVPLSRLFDHAMLQAHRAHQL
10 20 30 40
70 80 90 100 110
pF1KB6 SSEMFSEFDKRYT---HGRGFITKAINS-CHTSSLATPEDKEQAQQMNQKDFLSLIVSIL
. . ..::.. : . .:. . .: : ..:. :: . :..:: .. ..: . . ..
NP_072 AIDTYQEFEETYIPKDQKYSFLHDSQTSFCFSDSIPTPSNMEETQQKSNLELLRISLLLI
50 60 70 80 90 100
120 130 140 150 160 170
pF1KB6 RSWNEPLYHLVTEVRGMQEAPEAILSKAVEIEEQTKRLLEGMELIVSQVHPETKENEIYP
.:: ::. :
NP_072 ESWLEPVRFLRSMFANNLVYDTSDSDDYHLLKDLEEGIQTLMGVRVAPGVANPGTPLA
110 120 130 140 150 160
227 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sat Nov 5 02:44:55 2016 done: Sat Nov 5 02:44:56 2016
Total Scan time: 6.630 Total Display time: 0.000
Function used was FASTA [36.3.4 Apr, 2011]