FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE1466, 665 aa 1>>>pF1KE1466 665 - 665 aa - 665 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 12.6801+/-0.000419; mu= -13.4838+/- 0.026 mean_var=447.9194+/-94.098, 0's: 0 Z-trim(123.3): 136 B-trim: 320 in 1/60 Lambda= 0.060600 statistics sampled from 42792 (42943) to 42792 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.789), E-opt: 0.2 (0.503), width: 16 Scan time: 12.210 The best scores are: opt bits E(85289) NP_114098 (OMIM: 300374) SH3 domain-containing kin ( 665) 4393 398.6 3.8e-110 XP_016884952 (OMIM: 300374) PREDICTED: SH3 domain- ( 634) 4022 366.2 2.1e-100 XP_016884954 (OMIM: 300374) PREDICTED: SH3 domain- ( 624) 4019 365.9 2.5e-100 NP_001019837 (OMIM: 300374) SH3 domain-containing ( 628) 4019 365.9 2.5e-100 XP_016884955 (OMIM: 300374) PREDICTED: SH3 domain- ( 622) 3352 307.6 9e-83 XP_016884950 (OMIM: 300374) PREDICTED: SH3 domain- ( 649) 3235 297.4 1.1e-79 XP_016884949 (OMIM: 300374) PREDICTED: SH3 domain- ( 668) 3235 297.4 1.1e-79 XP_011543801 (OMIM: 300374) PREDICTED: SH3 domain- ( 672) 3235 297.4 1.1e-79 XP_016884948 (OMIM: 300374) PREDICTED: SH3 domain- ( 678) 3235 297.4 1.2e-79 XP_005274551 (OMIM: 300374) PREDICTED: SH3 domain- ( 690) 3235 297.4 1.2e-79 XP_011543800 (OMIM: 300374) PREDICTED: SH3 domain- ( 709) 3235 297.4 1.2e-79 XP_016884957 (OMIM: 300374) PREDICTED: SH3 domain- ( 581) 2978 274.9 6e-73 NP_001171889 (OMIM: 300374) SH3 domain-containing ( 427) 2803 259.5 1.9e-68 XP_011543804 (OMIM: 300374) PREDICTED: SH3 domain- ( 444) 2797 259.0 2.8e-68 XP_016884958 (OMIM: 300374) PREDICTED: SH3 domain- ( 404) 2681 248.8 3e-65 XP_016884956 (OMIM: 300374) PREDICTED: SH3 domain- ( 606) 2194 206.3 2.6e-52 XP_016884953 (OMIM: 300374) PREDICTED: SH3 domain- ( 625) 2194 206.3 2.7e-52 XP_016884951 (OMIM: 300374) PREDICTED: SH3 domain- ( 647) 2194 206.4 2.8e-52 XP_011543802 (OMIM: 300374) PREDICTED: SH3 domain- ( 666) 2194 206.4 2.8e-52 XP_016884959 (OMIM: 300374) PREDICTED: SH3 domain- ( 384) 1762 168.4 4.4e-41 XP_011543805 (OMIM: 300374) PREDICTED: SH3 domain- ( 426) 1385 135.5 4e-31 NP_036252 (OMIM: 604241,607832) CD2-associated pro ( 639) 1125 112.9 3.8e-24 XP_016866130 (OMIM: 604241,607832) PREDICTED: CD2- ( 476) 1085 109.3 3.4e-23 XP_011512751 (OMIM: 604241,607832) PREDICTED: CD2- ( 590) 878 91.3 1.1e-17 XP_005249033 (OMIM: 604241,607832) PREDICTED: CD2- ( 635) 449 53.8 2.3e-06 NP_006425 (OMIM: 605264) sorbin and SH3 domain-con ( 684) 314 42.0 0.0087 XP_006717656 (OMIM: 605264) PREDICTED: sorbin and ( 740) 314 42.0 0.0093 NP_001030129 (OMIM: 605264) sorbin and SH3 domain- ( 740) 314 42.0 0.0093 NP_001277224 (OMIM: 605264) sorbin and SH3 domain- ( 749) 314 42.0 0.0094 XP_016871029 (OMIM: 605264) PREDICTED: sorbin and ( 765) 314 42.0 0.0095 XP_016871028 (OMIM: 605264) PREDICTED: sorbin and ( 768) 314 42.1 0.0096 XP_016871027 (OMIM: 605264) PREDICTED: sorbin and ( 769) 314 42.1 0.0096 XP_016871026 (OMIM: 605264) PREDICTED: sorbin and ( 772) 314 42.1 0.0096 XP_016871025 (OMIM: 605264) PREDICTED: sorbin and ( 774) 314 42.1 0.0096 XP_016871024 (OMIM: 605264) PREDICTED: sorbin and ( 777) 314 42.1 0.0096 XP_016871023 (OMIM: 605264) PREDICTED: sorbin and ( 778) 314 42.1 0.0097 NP_079267 (OMIM: 605264) sorbin and SH3 domain-con ( 781) 314 42.1 0.0097 XP_016871022 (OMIM: 605264) PREDICTED: sorbin and ( 793) 314 42.1 0.0098 XP_016871021 (OMIM: 605264) PREDICTED: sorbin and ( 800) 314 42.1 0.0099 XP_016871020 (OMIM: 605264) PREDICTED: sorbin and ( 802) 314 42.1 0.0099 XP_016871019 (OMIM: 605264) PREDICTED: sorbin and ( 806) 314 42.1 0.0099 XP_016871018 (OMIM: 605264) PREDICTED: sorbin and ( 809) 314 42.1 0.01 NP_001277226 (OMIM: 605264) sorbin and SH3 domain- ( 811) 314 42.1 0.01 >>NP_114098 (OMIM: 300374) SH3 domain-containing kinase- (665 aa) initn: 4393 init1: 4393 opt: 4393 Z-score: 2098.5 bits: 398.6 E(85289): 3.8e-110 Smith-Waterman score: 4393; 99.8% identity (100.0% similar) in 665 aa overlap (1-665:1-665) 10 20 30 40 50 60 pF1KE1 MVEAIVEFDYQAQHDDELTISVGEIITNIRKEDGGWWEGQINGRRGLFPDNFVREIKKEM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_114 MVEAIVEFDYQAQHDDELTISVGEIITNIRKEDGGWWEGQINGRRGLFPDNFVREIKKEM 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 KKDPLTNKAPEKPLHEVPSGNSLLSSETILRTNKRGERRRRRCQVAFSYLPQNDDELELK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_114 KKDPLTNKAPEKPLHEVPSGNSLLSSETILRTNKRGERRRRRCQVAFSYLPQNDDELELK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 VGDIIEVVGEVEEGWWEGVLNGKTGMFPSNFIKELSGESDELGISQDEQLSKSSLRETTG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_114 VGDIIEVVGEVEEGWWEGVLNGKTGMFPSNFIKELSGESDELGISQDEQLSKSSLRETTG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 SESDGGDSSSTKSEGANGTVATAAIQPKKVKGVGFGDIFKDKPIKLRPRSIEVENDFLPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_114 SESDGGDSSSTKSEGANGTVATAAIQPKKVKGVGFGDIFKDKPIKLRPRSIEVENDFLPV 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE1 EKTIGKKLPATTATPDSSKTEMDSRTKSKDYCKVIFPYEAQNDDELTIKEGDIVTLINKD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_114 EKTIGKKLPATTATPDSSKTEMDSRTKSKDYCKVIFPYEAQNDDELTIKEGDIVTLINKD 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE1 CIDVGWWEGELNGRRGVFPDNFVKLLPPDFEKEGNRPKKPPPPSAPVIKQGAGTTERKHE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_114 CIDVGWWEGELNGRRGVFPDNFVKLLPPDFEKEGNRPKKPPPPSAPVIKQGAGTTERKHE 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE1 IKKIPPERPEMLPNRTEEKERPEREPKLDLQKPSVPAIPPKKPRPPKTNSLSRPGALPPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_114 IKKIPPERPEMLPNRTEEKERPEREPKLDLQKPSVPAIPPKKPRPPKTNSLSRPGALPPR 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE1 RPERPVGPLTHTRGDSPKIDLAGSSLSGILDKDLSDRSNDIDLEGFDSVVSSTEKLSHPT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_114 RPERPVGPLTHTRGDSPKIDLAGSSLSGILDKDLSDRSNDIDLEGFDSVVSSTEKLSHPT 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE1 TSRPKATGRRPPSQSLTSSSLSSPDIFDSPSPEEDKEEHISLAHRGVDASKKTSKTVTIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_114 TSRPKATGRRPPSQSLTSSSLSSPDIFDSPSPEEDKEEHISLAHRGVDASKKTSKTVTIS 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE1 QVSDNKASLPPKPGTMAAGGGGPAPLSSAVPSPLSSSLGTAGHRANSPSLFGTEGKPKME :::::::::::::::::::::::::::::.:::::::::::::::::::::::::::::: NP_114 QVSDNKASLPPKPGTMAAGGGGPAPLSSAAPSPLSSSLGTAGHRANSPSLFGTEGKPKME 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE1 PAASSQAAVEELRTQVRELRSIIETMKDQQKREIKQLLSELDEEKKIRLRLQMEVNDIKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_114 PAASSQAAVEELRTQVRELRSIIETMKDQQKREIKQLLSELDEEKKIRLRLQMEVNDIKK 610 620 630 640 650 660 pF1KE1 ALQSK ::::: NP_114 ALQSK >>XP_016884952 (OMIM: 300374) PREDICTED: SH3 domain-cont (634 aa) initn: 4019 init1: 4019 opt: 4022 Z-score: 1923.5 bits: 366.2 E(85289): 2.1e-100 Smith-Waterman score: 4022; 98.9% identity (99.4% similar) in 619 aa overlap (47-665:17-634) 20 30 40 50 60 70 pF1KE1 ELTISVGEIITNIRKEDGGWWEGQINGRRGLFPDNFVREIKKEMKKDPLTNKAPEKPLHE :. : . :::::::::::::::::::::: XP_016 MDSDKPRKSLLLWGEFLYTDLYF-EIKKEMKKDPLTNKAPEKPLHE 10 20 30 40 80 90 100 110 120 130 pF1KE1 VPSGNSLLSSETILRTNKRGERRRRRCQVAFSYLPQNDDELELKVGDIIEVVGEVEEGWW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VPSGNSLLSSETILRTNKRGERRRRRCQVAFSYLPQNDDELELKVGDIIEVVGEVEEGWW 50 60 70 80 90 100 140 150 160 170 180 190 pF1KE1 EGVLNGKTGMFPSNFIKELSGESDELGISQDEQLSKSSLRETTGSESDGGDSSSTKSEGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EGVLNGKTGMFPSNFIKELSGESDELGISQDEQLSKSSLRETTGSESDGGDSSSTKSEGA 110 120 130 140 150 160 200 210 220 230 240 250 pF1KE1 NGTVATAAIQPKKVKGVGFGDIFKDKPIKLRPRSIEVENDFLPVEKTIGKKLPATTATPD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NGTVATAAIQPKKVKGVGFGDIFKDKPIKLRPRSIEVENDFLPVEKTIGKKLPATTATPD 170 180 190 200 210 220 260 270 280 290 300 310 pF1KE1 SSKTEMDSRTKSKDYCKVIFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGRRG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SSKTEMDSRTKSKDYCKVIFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGRRG 230 240 250 260 270 280 320 330 340 350 360 370 pF1KE1 VFPDNFVKLLPPDFEKEGNRPKKPPPPSAPVIKQGAGTTERKHEIKKIPPERPEMLPNRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VFPDNFVKLLPPDFEKEGNRPKKPPPPSAPVIKQGAGTTERKHEIKKIPPERPEMLPNRT 290 300 310 320 330 340 380 390 400 410 420 430 pF1KE1 EEKERPEREPKLDLQKPSVPAIPPKKPRPPKTNSLSRPGALPPRRPERPVGPLTHTRGDS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EEKERPEREPKLDLQKPSVPAIPPKKPRPPKTNSLSRPGALPPRRPERPVGPLTHTRGDS 350 360 370 380 390 400 440 450 460 470 480 490 pF1KE1 PKIDLAGSSLSGILDKDLSDRSNDIDLEGFDSVVSSTEKLSHPTTSRPKATGRRPPSQSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PKIDLAGSSLSGILDKDLSDRSNDIDLEGFDSVVSSTEKLSHPTTSRPKATGRRPPSQSL 410 420 430 440 450 460 500 510 520 530 540 550 pF1KE1 TSSSLSSPDIFDSPSPEEDKEEHISLAHRGVDASKKTSKTVTISQVSDNKASLPPKPGTM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TSSSLSSPDIFDSPSPEEDKEEHISLAHRGVDASKKTSKTVTISQVSDNKASLPPKPGTM 470 480 490 500 510 520 560 570 580 590 600 610 pF1KE1 AAGGGGPAPLSSAVPSPLSSSLGTAGHRANSPSLFGTEGKPKMEPAASSQAAVEELRTQV :::::::::::::.:::::::::::::::::::::::::::::::::::::::::::::: XP_016 AAGGGGPAPLSSAAPSPLSSSLGTAGHRANSPSLFGTEGKPKMEPAASSQAAVEELRTQV 530 540 550 560 570 580 620 630 640 650 660 pF1KE1 RELRSIIETMKDQQKREIKQLLSELDEEKKIRLRLQMEVNDIKKALQSK ::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RELRSIIETMKDQQKREIKQLLSELDEEKKIRLRLQMEVNDIKKALQSK 590 600 610 620 630 >>XP_016884954 (OMIM: 300374) PREDICTED: SH3 domain-cont (624 aa) initn: 4019 init1: 4019 opt: 4019 Z-score: 1922.1 bits: 365.9 E(85289): 2.5e-100 Smith-Waterman score: 4019; 99.8% identity (100.0% similar) in 611 aa overlap (55-665:14-624) 30 40 50 60 70 80 pF1KE1 IITNIRKEDGGWWEGQINGRRGLFPDNFVREIKKEMKKDPLTNKAPEKPLHEVPSGNSLL :::::::::::::::::::::::::::::: XP_016 MEAGGRDRSTAGEEIKKEMKKDPLTNKAPEKPLHEVPSGNSLL 10 20 30 40 90 100 110 120 130 140 pF1KE1 SSETILRTNKRGERRRRRCQVAFSYLPQNDDELELKVGDIIEVVGEVEEGWWEGVLNGKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SSETILRTNKRGERRRRRCQVAFSYLPQNDDELELKVGDIIEVVGEVEEGWWEGVLNGKT 50 60 70 80 90 100 150 160 170 180 190 200 pF1KE1 GMFPSNFIKELSGESDELGISQDEQLSKSSLRETTGSESDGGDSSSTKSEGANGTVATAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GMFPSNFIKELSGESDELGISQDEQLSKSSLRETTGSESDGGDSSSTKSEGANGTVATAA 110 120 130 140 150 160 210 220 230 240 250 260 pF1KE1 IQPKKVKGVGFGDIFKDKPIKLRPRSIEVENDFLPVEKTIGKKLPATTATPDSSKTEMDS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IQPKKVKGVGFGDIFKDKPIKLRPRSIEVENDFLPVEKTIGKKLPATTATPDSSKTEMDS 170 180 190 200 210 220 270 280 290 300 310 320 pF1KE1 RTKSKDYCKVIFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGRRGVFPDNFVK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RTKSKDYCKVIFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGRRGVFPDNFVK 230 240 250 260 270 280 330 340 350 360 370 380 pF1KE1 LLPPDFEKEGNRPKKPPPPSAPVIKQGAGTTERKHEIKKIPPERPEMLPNRTEEKERPER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LLPPDFEKEGNRPKKPPPPSAPVIKQGAGTTERKHEIKKIPPERPEMLPNRTEEKERPER 290 300 310 320 330 340 390 400 410 420 430 440 pF1KE1 EPKLDLQKPSVPAIPPKKPRPPKTNSLSRPGALPPRRPERPVGPLTHTRGDSPKIDLAGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EPKLDLQKPSVPAIPPKKPRPPKTNSLSRPGALPPRRPERPVGPLTHTRGDSPKIDLAGS 350 360 370 380 390 400 450 460 470 480 490 500 pF1KE1 SLSGILDKDLSDRSNDIDLEGFDSVVSSTEKLSHPTTSRPKATGRRPPSQSLTSSSLSSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SLSGILDKDLSDRSNDIDLEGFDSVVSSTEKLSHPTTSRPKATGRRPPSQSLTSSSLSSP 410 420 430 440 450 460 510 520 530 540 550 560 pF1KE1 DIFDSPSPEEDKEEHISLAHRGVDASKKTSKTVTISQVSDNKASLPPKPGTMAAGGGGPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DIFDSPSPEEDKEEHISLAHRGVDASKKTSKTVTISQVSDNKASLPPKPGTMAAGGGGPA 470 480 490 500 510 520 570 580 590 600 610 620 pF1KE1 PLSSAVPSPLSSSLGTAGHRANSPSLFGTEGKPKMEPAASSQAAVEELRTQVRELRSIIE :::::.:::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PLSSAAPSPLSSSLGTAGHRANSPSLFGTEGKPKMEPAASSQAAVEELRTQVRELRSIIE 530 540 550 560 570 580 630 640 650 660 pF1KE1 TMKDQQKREIKQLLSELDEEKKIRLRLQMEVNDIKKALQSK ::::::::::::::::::::::::::::::::::::::::: XP_016 TMKDQQKREIKQLLSELDEEKKIRLRLQMEVNDIKKALQSK 590 600 610 620 >>NP_001019837 (OMIM: 300374) SH3 domain-containing kina (628 aa) initn: 4019 init1: 4019 opt: 4019 Z-score: 1922.1 bits: 365.9 E(85289): 2.5e-100 Smith-Waterman score: 4019; 99.8% identity (100.0% similar) in 611 aa overlap (55-665:18-628) 30 40 50 60 70 80 pF1KE1 IITNIRKEDGGWWEGQINGRRGLFPDNFVREIKKEMKKDPLTNKAPEKPLHEVPSGNSLL :::::::::::::::::::::::::::::: NP_001 MEVSAAKAPSAADLSEIEIKKEMKKDPLTNKAPEKPLHEVPSGNSLL 10 20 30 40 90 100 110 120 130 140 pF1KE1 SSETILRTNKRGERRRRRCQVAFSYLPQNDDELELKVGDIIEVVGEVEEGWWEGVLNGKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SSETILRTNKRGERRRRRCQVAFSYLPQNDDELELKVGDIIEVVGEVEEGWWEGVLNGKT 50 60 70 80 90 100 150 160 170 180 190 200 pF1KE1 GMFPSNFIKELSGESDELGISQDEQLSKSSLRETTGSESDGGDSSSTKSEGANGTVATAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GMFPSNFIKELSGESDELGISQDEQLSKSSLRETTGSESDGGDSSSTKSEGANGTVATAA 110 120 130 140 150 160 210 220 230 240 250 260 pF1KE1 IQPKKVKGVGFGDIFKDKPIKLRPRSIEVENDFLPVEKTIGKKLPATTATPDSSKTEMDS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IQPKKVKGVGFGDIFKDKPIKLRPRSIEVENDFLPVEKTIGKKLPATTATPDSSKTEMDS 170 180 190 200 210 220 270 280 290 300 310 320 pF1KE1 RTKSKDYCKVIFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGRRGVFPDNFVK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RTKSKDYCKVIFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGRRGVFPDNFVK 230 240 250 260 270 280 330 340 350 360 370 380 pF1KE1 LLPPDFEKEGNRPKKPPPPSAPVIKQGAGTTERKHEIKKIPPERPEMLPNRTEEKERPER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LLPPDFEKEGNRPKKPPPPSAPVIKQGAGTTERKHEIKKIPPERPEMLPNRTEEKERPER 290 300 310 320 330 340 390 400 410 420 430 440 pF1KE1 EPKLDLQKPSVPAIPPKKPRPPKTNSLSRPGALPPRRPERPVGPLTHTRGDSPKIDLAGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EPKLDLQKPSVPAIPPKKPRPPKTNSLSRPGALPPRRPERPVGPLTHTRGDSPKIDLAGS 350 360 370 380 390 400 450 460 470 480 490 500 pF1KE1 SLSGILDKDLSDRSNDIDLEGFDSVVSSTEKLSHPTTSRPKATGRRPPSQSLTSSSLSSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SLSGILDKDLSDRSNDIDLEGFDSVVSSTEKLSHPTTSRPKATGRRPPSQSLTSSSLSSP 410 420 430 440 450 460 510 520 530 540 550 560 pF1KE1 DIFDSPSPEEDKEEHISLAHRGVDASKKTSKTVTISQVSDNKASLPPKPGTMAAGGGGPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DIFDSPSPEEDKEEHISLAHRGVDASKKTSKTVTISQVSDNKASLPPKPGTMAAGGGGPA 470 480 490 500 510 520 570 580 590 600 610 620 pF1KE1 PLSSAVPSPLSSSLGTAGHRANSPSLFGTEGKPKMEPAASSQAAVEELRTQVRELRSIIE :::::.:::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PLSSAAPSPLSSSLGTAGHRANSPSLFGTEGKPKMEPAASSQAAVEELRTQVRELRSIIE 530 540 550 560 570 580 630 640 650 660 pF1KE1 TMKDQQKREIKQLLSELDEEKKIRLRLQMEVNDIKKALQSK ::::::::::::::::::::::::::::::::::::::::: NP_001 TMKDQQKREIKQLLSELDEEKKIRLRLQMEVNDIKKALQSK 590 600 610 620 >>XP_016884955 (OMIM: 300374) PREDICTED: SH3 domain-cont (622 aa) initn: 3714 init1: 3349 opt: 3352 Z-score: 1607.0 bits: 307.6 E(85289): 9e-83 Smith-Waterman score: 4027; 93.4% identity (93.5% similar) in 665 aa overlap (1-665:1-622) 10 20 30 40 50 60 pF1KE1 MVEAIVEFDYQAQHDDELTISVGEIITNIRKEDGGWWEGQINGRRGLFPDNFVREIKKEM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MVEAIVEFDYQAQHDDELTISVGEIITNIRKEDGGWWEGQINGRRGLFPDNFVREIKKEM 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 KKDPLTNKAPEKPLHEVPSGNSLLSSETILRTNKRGERRRRRCQVAFSYLPQNDDELELK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KKDPLTNKAPEKPLHEVPSGNSLLSSETILRTNKRGERRRRRCQVAFSYLPQNDDELELK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 VGDIIEVVGEVEEGWWEGVLNGKTGMFPSNFIKELSGESDELGISQDEQLSKSSLRETTG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VGDIIEVVGEVEEGWWEGVLNGKTGMFPSNFIKELSGESDELGISQDEQLSKSSLRETTG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 SESDGGDSSSTKSEGANGTVATAAIQPKKVKGVGFGDIFKDKPIKLRPRSIEVENDFLPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SESDGGDSSSTKSEGANGTVATAAIQPKKVKGVGFGDIFKDKPIKLRPRSIEVENDFLPV 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE1 EKTIGKKLPATTATPDSSKTEMDSRTKSKDYCKVIFPYEAQNDDELTIKEGDIVTLINKD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EKTIGKKLPATTATPDSSKTEMDSRTKSKDYCKVIFPYEAQNDDELTIKEGDIVTLINKD 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE1 CIDVGWWEGELNGRRGVFPDNFVKLLPPDFEKEGNRPKKPPPPSAPVIKQGAGTTERKHE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CIDVGWWEGELNGRRGVFPDNFVKLLPPDFEKEGNRPKKPPPPSAPVIKQGAGTTERKHE 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE1 IKKIPPERPEMLPNRTEEKERPEREPKLDLQKPSVPAIPPKKPRPPKTNSLSRPGALPPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IKKIPPERPEMLPNRTEEKERPEREPKLDLQKPSVPAIPPKKPRPPKTNSLSRPGALPPR 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE1 RPERPVGPLTHTRGDSPKIDLAGSSLSGILDKDLSDRSNDIDLEGFDSVVSSTEKLSHPT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RPERPVGPLTHTRGDSPKIDLAGSSLSGILDKDLSDRSNDIDLEGFDSVVSSTEKLSHPT 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE1 TSRPKATGRRPPSQSLTSSSLSSPDIFDSPSPEEDKEEHISLAHRGVDASKKTSKTVTIS :::::::::::::::::: XP_016 TSRPKATGRRPPSQSLTS------------------------------------------ 490 550 560 570 580 590 600 pF1KE1 QVSDNKASLPPKPGTMAAGGGGPAPLSSAVPSPLSSSLGTAGHRANSPSLFGTEGKPKME ::::::::::::::::::::::::::::.:::::::::::::::::::::::::::::: XP_016 -VSDNKASLPPKPGTMAAGGGGPAPLSSAAPSPLSSSLGTAGHRANSPSLFGTEGKPKME 500 510 520 530 540 550 610 620 630 640 650 660 pF1KE1 PAASSQAAVEELRTQVRELRSIIETMKDQQKREIKQLLSELDEEKKIRLRLQMEVNDIKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PAASSQAAVEELRTQVRELRSIIETMKDQQKREIKQLLSELDEEKKIRLRLQMEVNDIKK 560 570 580 590 600 610 pF1KE1 ALQSK ::::: XP_016 ALQSK 620 >>XP_016884950 (OMIM: 300374) PREDICTED: SH3 domain-cont (649 aa) initn: 3235 init1: 3235 opt: 3235 Z-score: 1551.5 bits: 297.4 E(85289): 1.1e-79 Smith-Waterman score: 3959; 95.9% identity (96.1% similar) in 636 aa overlap (55-665:14-649) 30 40 50 60 70 80 pF1KE1 IITNIRKEDGGWWEGQINGRRGLFPDNFVREIKKEMKKDPLTNKAPEKPLHEVPSGNSLL :::::::::::::::::::::::::::::: XP_016 MEAGGRDRSTAGEEIKKEMKKDPLTNKAPEKPLHEVPSGNSLL 10 20 30 40 90 100 110 120 130 140 pF1KE1 SSETILRTNKRGERRRRRCQVAFSYLPQNDDELELKVGDIIEVVGEVEEGWWEGVLNGKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SSETILRTNKRGERRRRRCQVAFSYLPQNDDELELKVGDIIEVVGEVEEGWWEGVLNGKT 50 60 70 80 90 100 150 160 170 pF1KE1 GMFPSNFIKELSGESDELGISQDEQLSKS-------------------------SLRETT ::::::::::::::::::::::::::::: :::::: XP_016 GMFPSNFIKELSGESDELGISQDEQLSKSRKTTFEGTILYRAAPGKTEGHRRYYSLRETT 110 120 130 140 150 160 180 190 200 210 220 230 pF1KE1 GSESDGGDSSSTKSEGANGTVATAAIQPKKVKGVGFGDIFKDKPIKLRPRSIEVENDFLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GSESDGGDSSSTKSEGANGTVATAAIQPKKVKGVGFGDIFKDKPIKLRPRSIEVENDFLP 170 180 190 200 210 220 240 250 260 270 280 290 pF1KE1 VEKTIGKKLPATTATPDSSKTEMDSRTKSKDYCKVIFPYEAQNDDELTIKEGDIVTLINK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VEKTIGKKLPATTATPDSSKTEMDSRTKSKDYCKVIFPYEAQNDDELTIKEGDIVTLINK 230 240 250 260 270 280 300 310 320 330 340 350 pF1KE1 DCIDVGWWEGELNGRRGVFPDNFVKLLPPDFEKEGNRPKKPPPPSAPVIKQGAGTTERKH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DCIDVGWWEGELNGRRGVFPDNFVKLLPPDFEKEGNRPKKPPPPSAPVIKQGAGTTERKH 290 300 310 320 330 340 360 370 380 390 400 410 pF1KE1 EIKKIPPERPEMLPNRTEEKERPEREPKLDLQKPSVPAIPPKKPRPPKTNSLSRPGALPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EIKKIPPERPEMLPNRTEEKERPEREPKLDLQKPSVPAIPPKKPRPPKTNSLSRPGALPP 350 360 370 380 390 400 420 430 440 450 460 470 pF1KE1 RRPERPVGPLTHTRGDSPKIDLAGSSLSGILDKDLSDRSNDIDLEGFDSVVSSTEKLSHP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RRPERPVGPLTHTRGDSPKIDLAGSSLSGILDKDLSDRSNDIDLEGFDSVVSSTEKLSHP 410 420 430 440 450 460 480 490 500 510 520 530 pF1KE1 TTSRPKATGRRPPSQSLTSSSLSSPDIFDSPSPEEDKEEHISLAHRGVDASKKTSKTVTI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TTSRPKATGRRPPSQSLTSSSLSSPDIFDSPSPEEDKEEHISLAHRGVDASKKTSKTVTI 470 480 490 500 510 520 540 550 560 570 580 590 pF1KE1 SQVSDNKASLPPKPGTMAAGGGGPAPLSSAVPSPLSSSLGTAGHRANSPSLFGTEGKPKM ::::::::::::::::::::::::::::::.::::::::::::::::::::::::::::: XP_016 SQVSDNKASLPPKPGTMAAGGGGPAPLSSAAPSPLSSSLGTAGHRANSPSLFGTEGKPKM 530 540 550 560 570 580 600 610 620 630 640 650 pF1KE1 EPAASSQAAVEELRTQVRELRSIIETMKDQQKREIKQLLSELDEEKKIRLRLQMEVNDIK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EPAASSQAAVEELRTQVRELRSIIETMKDQQKREIKQLLSELDEEKKIRLRLQMEVNDIK 590 600 610 620 630 640 660 pF1KE1 KALQSK :::::: XP_016 KALQSK >>XP_016884949 (OMIM: 300374) PREDICTED: SH3 domain-cont (668 aa) initn: 4005 init1: 3235 opt: 3235 Z-score: 1551.3 bits: 297.4 E(85289): 1.1e-79 Smith-Waterman score: 3921; 93.1% identity (93.3% similar) in 655 aa overlap (55-665:14-668) 30 40 50 60 70 80 pF1KE1 IITNIRKEDGGWWEGQINGRRGLFPDNFVREIKKEMKKDPLTNKAPEKPLHEVPSGNSLL :::::::::::::::::::::::::::::: XP_016 MEAGGRDRSTAGEEIKKEMKKDPLTNKAPEKPLHEVPSGNSLL 10 20 30 40 90 100 110 120 130 140 pF1KE1 SSETILRTNKRGERRRRRCQVAFSYLPQNDDELELKVGDIIEVVGEVEEGWWEGVLNGKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SSETILRTNKRGERRRRRCQVAFSYLPQNDDELELKVGDIIEVVGEVEEGWWEGVLNGKT 50 60 70 80 90 100 150 160 170 pF1KE1 GMFPSNFIKELSGESDELGISQDEQLSKS------------------------------- ::::::::::::::::::::::::::::: XP_016 GMFPSNFIKELSGESDELGISQDEQLSKSRPEGLPPASLLPFPAHGAKGKTTFEGTILYR 110 120 130 140 150 160 180 190 200 210 220 pF1KE1 -------------SLRETTGSESDGGDSSSTKSEGANGTVATAAIQPKKVKGVGFGDIFK ::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AAPGKTEGHRRYYSLRETTGSESDGGDSSSTKSEGANGTVATAAIQPKKVKGVGFGDIFK 170 180 190 200 210 220 230 240 250 260 270 280 pF1KE1 DKPIKLRPRSIEVENDFLPVEKTIGKKLPATTATPDSSKTEMDSRTKSKDYCKVIFPYEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DKPIKLRPRSIEVENDFLPVEKTIGKKLPATTATPDSSKTEMDSRTKSKDYCKVIFPYEA 230 240 250 260 270 280 290 300 310 320 330 340 pF1KE1 QNDDELTIKEGDIVTLINKDCIDVGWWEGELNGRRGVFPDNFVKLLPPDFEKEGNRPKKP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QNDDELTIKEGDIVTLINKDCIDVGWWEGELNGRRGVFPDNFVKLLPPDFEKEGNRPKKP 290 300 310 320 330 340 350 360 370 380 390 400 pF1KE1 PPPSAPVIKQGAGTTERKHEIKKIPPERPEMLPNRTEEKERPEREPKLDLQKPSVPAIPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PPPSAPVIKQGAGTTERKHEIKKIPPERPEMLPNRTEEKERPEREPKLDLQKPSVPAIPP 350 360 370 380 390 400 410 420 430 440 450 460 pF1KE1 KKPRPPKTNSLSRPGALPPRRPERPVGPLTHTRGDSPKIDLAGSSLSGILDKDLSDRSND :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KKPRPPKTNSLSRPGALPPRRPERPVGPLTHTRGDSPKIDLAGSSLSGILDKDLSDRSND 410 420 430 440 450 460 470 480 490 500 510 520 pF1KE1 IDLEGFDSVVSSTEKLSHPTTSRPKATGRRPPSQSLTSSSLSSPDIFDSPSPEEDKEEHI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IDLEGFDSVVSSTEKLSHPTTSRPKATGRRPPSQSLTSSSLSSPDIFDSPSPEEDKEEHI 470 480 490 500 510 520 530 540 550 560 570 580 pF1KE1 SLAHRGVDASKKTSKTVTISQVSDNKASLPPKPGTMAAGGGGPAPLSSAVPSPLSSSLGT :::::::::::::::::::::::::::::::::::::::::::::::::.:::::::::: XP_016 SLAHRGVDASKKTSKTVTISQVSDNKASLPPKPGTMAAGGGGPAPLSSAAPSPLSSSLGT 530 540 550 560 570 580 590 600 610 620 630 640 pF1KE1 AGHRANSPSLFGTEGKPKMEPAASSQAAVEELRTQVRELRSIIETMKDQQKREIKQLLSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AGHRANSPSLFGTEGKPKMEPAASSQAAVEELRTQVRELRSIIETMKDQQKREIKQLLSE 590 600 610 620 630 640 650 660 pF1KE1 LDEEKKIRLRLQMEVNDIKKALQSK ::::::::::::::::::::::::: XP_016 LDEEKKIRLRLQMEVNDIKKALQSK 650 660 >>XP_011543801 (OMIM: 300374) PREDICTED: SH3 domain-cont (672 aa) initn: 4005 init1: 3235 opt: 3235 Z-score: 1551.2 bits: 297.4 E(85289): 1.1e-79 Smith-Waterman score: 3921; 93.1% identity (93.3% similar) in 655 aa overlap (55-665:18-672) 30 40 50 60 70 80 pF1KE1 IITNIRKEDGGWWEGQINGRRGLFPDNFVREIKKEMKKDPLTNKAPEKPLHEVPSGNSLL :::::::::::::::::::::::::::::: XP_011 MEVSAAKAPSAADLSEIEIKKEMKKDPLTNKAPEKPLHEVPSGNSLL 10 20 30 40 90 100 110 120 130 140 pF1KE1 SSETILRTNKRGERRRRRCQVAFSYLPQNDDELELKVGDIIEVVGEVEEGWWEGVLNGKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SSETILRTNKRGERRRRRCQVAFSYLPQNDDELELKVGDIIEVVGEVEEGWWEGVLNGKT 50 60 70 80 90 100 150 160 170 pF1KE1 GMFPSNFIKELSGESDELGISQDEQLSKS------------------------------- ::::::::::::::::::::::::::::: XP_011 GMFPSNFIKELSGESDELGISQDEQLSKSRPEGLPPASLLPFPAHGAKGKTTFEGTILYR 110 120 130 140 150 160 180 190 200 210 220 pF1KE1 -------------SLRETTGSESDGGDSSSTKSEGANGTVATAAIQPKKVKGVGFGDIFK ::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AAPGKTEGHRRYYSLRETTGSESDGGDSSSTKSEGANGTVATAAIQPKKVKGVGFGDIFK 170 180 190 200 210 220 230 240 250 260 270 280 pF1KE1 DKPIKLRPRSIEVENDFLPVEKTIGKKLPATTATPDSSKTEMDSRTKSKDYCKVIFPYEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DKPIKLRPRSIEVENDFLPVEKTIGKKLPATTATPDSSKTEMDSRTKSKDYCKVIFPYEA 230 240 250 260 270 280 290 300 310 320 330 340 pF1KE1 QNDDELTIKEGDIVTLINKDCIDVGWWEGELNGRRGVFPDNFVKLLPPDFEKEGNRPKKP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QNDDELTIKEGDIVTLINKDCIDVGWWEGELNGRRGVFPDNFVKLLPPDFEKEGNRPKKP 290 300 310 320 330 340 350 360 370 380 390 400 pF1KE1 PPPSAPVIKQGAGTTERKHEIKKIPPERPEMLPNRTEEKERPEREPKLDLQKPSVPAIPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PPPSAPVIKQGAGTTERKHEIKKIPPERPEMLPNRTEEKERPEREPKLDLQKPSVPAIPP 350 360 370 380 390 400 410 420 430 440 450 460 pF1KE1 KKPRPPKTNSLSRPGALPPRRPERPVGPLTHTRGDSPKIDLAGSSLSGILDKDLSDRSND :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KKPRPPKTNSLSRPGALPPRRPERPVGPLTHTRGDSPKIDLAGSSLSGILDKDLSDRSND 410 420 430 440 450 460 470 480 490 500 510 520 pF1KE1 IDLEGFDSVVSSTEKLSHPTTSRPKATGRRPPSQSLTSSSLSSPDIFDSPSPEEDKEEHI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IDLEGFDSVVSSTEKLSHPTTSRPKATGRRPPSQSLTSSSLSSPDIFDSPSPEEDKEEHI 470 480 490 500 510 520 530 540 550 560 570 580 pF1KE1 SLAHRGVDASKKTSKTVTISQVSDNKASLPPKPGTMAAGGGGPAPLSSAVPSPLSSSLGT :::::::::::::::::::::::::::::::::::::::::::::::::.:::::::::: XP_011 SLAHRGVDASKKTSKTVTISQVSDNKASLPPKPGTMAAGGGGPAPLSSAAPSPLSSSLGT 530 540 550 560 570 580 590 600 610 620 630 640 pF1KE1 AGHRANSPSLFGTEGKPKMEPAASSQAAVEELRTQVRELRSIIETMKDQQKREIKQLLSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AGHRANSPSLFGTEGKPKMEPAASSQAAVEELRTQVRELRSIIETMKDQQKREIKQLLSE 590 600 610 620 630 640 650 660 pF1KE1 LDEEKKIRLRLQMEVNDIKKALQSK ::::::::::::::::::::::::: XP_011 LDEEKKIRLRLQMEVNDIKKALQSK 650 660 670 >>XP_016884948 (OMIM: 300374) PREDICTED: SH3 domain-cont (678 aa) initn: 4005 init1: 3235 opt: 3235 Z-score: 1551.2 bits: 297.4 E(85289): 1.2e-79 Smith-Waterman score: 3924; 92.3% identity (92.8% similar) in 663 aa overlap (47-665:17-678) 20 30 40 50 60 70 pF1KE1 ELTISVGEIITNIRKEDGGWWEGQINGRRGLFPDNFVREIKKEMKKDPLTNKAPEKPLHE :. : . :::::::::::::::::::::: XP_016 MDSDKPRKSLLLWGEFLYTDLYF-EIKKEMKKDPLTNKAPEKPLHE 10 20 30 40 80 90 100 110 120 130 pF1KE1 VPSGNSLLSSETILRTNKRGERRRRRCQVAFSYLPQNDDELELKVGDIIEVVGEVEEGWW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VPSGNSLLSSETILRTNKRGERRRRRCQVAFSYLPQNDDELELKVGDIIEVVGEVEEGWW 50 60 70 80 90 100 140 150 160 170 pF1KE1 EGVLNGKTGMFPSNFIKELSGESDELGISQDEQLSKS----------------------- ::::::::::::::::::::::::::::::::::::: XP_016 EGVLNGKTGMFPSNFIKELSGESDELGISQDEQLSKSRPEGLPPASLLPFPAHGAKGKTT 110 120 130 140 150 160 180 190 200 210 pF1KE1 ---------------------SLRETTGSESDGGDSSSTKSEGANGTVATAAIQPKKVKG ::::::::::::::::::::::::::::::::::::::: XP_016 FEGTILYRAAPGKTEGHRRYYSLRETTGSESDGGDSSSTKSEGANGTVATAAIQPKKVKG 170 180 190 200 210 220 220 230 240 250 260 270 pF1KE1 VGFGDIFKDKPIKLRPRSIEVENDFLPVEKTIGKKLPATTATPDSSKTEMDSRTKSKDYC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VGFGDIFKDKPIKLRPRSIEVENDFLPVEKTIGKKLPATTATPDSSKTEMDSRTKSKDYC 230 240 250 260 270 280 280 290 300 310 320 330 pF1KE1 KVIFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGRRGVFPDNFVKLLPPDFEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KVIFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGRRGVFPDNFVKLLPPDFEK 290 300 310 320 330 340 340 350 360 370 380 390 pF1KE1 EGNRPKKPPPPSAPVIKQGAGTTERKHEIKKIPPERPEMLPNRTEEKERPEREPKLDLQK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EGNRPKKPPPPSAPVIKQGAGTTERKHEIKKIPPERPEMLPNRTEEKERPEREPKLDLQK 350 360 370 380 390 400 400 410 420 430 440 450 pF1KE1 PSVPAIPPKKPRPPKTNSLSRPGALPPRRPERPVGPLTHTRGDSPKIDLAGSSLSGILDK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PSVPAIPPKKPRPPKTNSLSRPGALPPRRPERPVGPLTHTRGDSPKIDLAGSSLSGILDK 410 420 430 440 450 460 460 470 480 490 500 510 pF1KE1 DLSDRSNDIDLEGFDSVVSSTEKLSHPTTSRPKATGRRPPSQSLTSSSLSSPDIFDSPSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DLSDRSNDIDLEGFDSVVSSTEKLSHPTTSRPKATGRRPPSQSLTSSSLSSPDIFDSPSP 470 480 490 500 510 520 520 530 540 550 560 570 pF1KE1 EEDKEEHISLAHRGVDASKKTSKTVTISQVSDNKASLPPKPGTMAAGGGGPAPLSSAVPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::.:: XP_016 EEDKEEHISLAHRGVDASKKTSKTVTISQVSDNKASLPPKPGTMAAGGGGPAPLSSAAPS 530 540 550 560 570 580 580 590 600 610 620 630 pF1KE1 PLSSSLGTAGHRANSPSLFGTEGKPKMEPAASSQAAVEELRTQVRELRSIIETMKDQQKR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PLSSSLGTAGHRANSPSLFGTEGKPKMEPAASSQAAVEELRTQVRELRSIIETMKDQQKR 590 600 610 620 630 640 640 650 660 pF1KE1 EIKQLLSELDEEKKIRLRLQMEVNDIKKALQSK ::::::::::::::::::::::::::::::::: XP_016 EIKQLLSELDEEKKIRLRLQMEVNDIKKALQSK 650 660 670 >>XP_005274551 (OMIM: 300374) PREDICTED: SH3 domain-cont (690 aa) initn: 3235 init1: 3235 opt: 3235 Z-score: 1551.1 bits: 297.4 E(85289): 1.2e-79 Smith-Waterman score: 4333; 96.2% identity (96.4% similar) in 690 aa overlap (1-665:1-690) 10 20 30 40 50 60 pF1KE1 MVEAIVEFDYQAQHDDELTISVGEIITNIRKEDGGWWEGQINGRRGLFPDNFVREIKKEM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MVEAIVEFDYQAQHDDELTISVGEIITNIRKEDGGWWEGQINGRRGLFPDNFVREIKKEM 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 KKDPLTNKAPEKPLHEVPSGNSLLSSETILRTNKRGERRRRRCQVAFSYLPQNDDELELK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KKDPLTNKAPEKPLHEVPSGNSLLSSETILRTNKRGERRRRRCQVAFSYLPQNDDELELK 70 80 90 100 110 120 130 140 150 160 170 pF1KE1 VGDIIEVVGEVEEGWWEGVLNGKTGMFPSNFIKELSGESDELGISQDEQLSKS------- ::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VGDIIEVVGEVEEGWWEGVLNGKTGMFPSNFIKELSGESDELGISQDEQLSKSRKTTFEG 130 140 150 160 170 180 180 190 200 210 pF1KE1 ------------------SLRETTGSESDGGDSSSTKSEGANGTVATAAIQPKKVKGVGF :::::::::::::::::::::::::::::::::::::::::: XP_005 TILYRAAPGKTEGHRRYYSLRETTGSESDGGDSSSTKSEGANGTVATAAIQPKKVKGVGF 190 200 210 220 230 240 220 230 240 250 260 270 pF1KE1 GDIFKDKPIKLRPRSIEVENDFLPVEKTIGKKLPATTATPDSSKTEMDSRTKSKDYCKVI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GDIFKDKPIKLRPRSIEVENDFLPVEKTIGKKLPATTATPDSSKTEMDSRTKSKDYCKVI 250 260 270 280 290 300 280 290 300 310 320 330 pF1KE1 FPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGRRGVFPDNFVKLLPPDFEKEGN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 FPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGRRGVFPDNFVKLLPPDFEKEGN 310 320 330 340 350 360 340 350 360 370 380 390 pF1KE1 RPKKPPPPSAPVIKQGAGTTERKHEIKKIPPERPEMLPNRTEEKERPEREPKLDLQKPSV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 RPKKPPPPSAPVIKQGAGTTERKHEIKKIPPERPEMLPNRTEEKERPEREPKLDLQKPSV 370 380 390 400 410 420 400 410 420 430 440 450 pF1KE1 PAIPPKKPRPPKTNSLSRPGALPPRRPERPVGPLTHTRGDSPKIDLAGSSLSGILDKDLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PAIPPKKPRPPKTNSLSRPGALPPRRPERPVGPLTHTRGDSPKIDLAGSSLSGILDKDLS 430 440 450 460 470 480 460 470 480 490 500 510 pF1KE1 DRSNDIDLEGFDSVVSSTEKLSHPTTSRPKATGRRPPSQSLTSSSLSSPDIFDSPSPEED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DRSNDIDLEGFDSVVSSTEKLSHPTTSRPKATGRRPPSQSLTSSSLSSPDIFDSPSPEED 490 500 510 520 530 540 520 530 540 550 560 570 pF1KE1 KEEHISLAHRGVDASKKTSKTVTISQVSDNKASLPPKPGTMAAGGGGPAPLSSAVPSPLS ::::::::::::::::::::::::::::::::::::::::::::::::::::::.::::: XP_005 KEEHISLAHRGVDASKKTSKTVTISQVSDNKASLPPKPGTMAAGGGGPAPLSSAAPSPLS 550 560 570 580 590 600 580 590 600 610 620 630 pF1KE1 SSLGTAGHRANSPSLFGTEGKPKMEPAASSQAAVEELRTQVRELRSIIETMKDQQKREIK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SSLGTAGHRANSPSLFGTEGKPKMEPAASSQAAVEELRTQVRELRSIIETMKDQQKREIK 610 620 630 640 650 660 640 650 660 pF1KE1 QLLSELDEEKKIRLRLQMEVNDIKKALQSK :::::::::::::::::::::::::::::: XP_005 QLLSELDEEKKIRLRLQMEVNDIKKALQSK 670 680 690 665 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Mon Nov 7 01:16:04 2016 done: Mon Nov 7 01:16:05 2016 Total Scan time: 12.210 Total Display time: 0.130 Function used was FASTA [36.3.4 Apr, 2011]