FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE4316, 323 aa 1>>>pF1KE4316 323 - 323 aa - 323 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.9477+/-0.000372; mu= 17.8100+/- 0.023 mean_var=63.5204+/-13.084, 0's: 0 Z-trim(112.8): 59 B-trim: 0 in 0/52 Lambda= 0.160923 statistics sampled from 21751 (21810) to 21751 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.633), E-opt: 0.2 (0.256), width: 16 Scan time: 7.350 The best scores are: opt bits E(85289) NP_001344 (OMIM: 600449) aldo-keto reductase famil ( 323) 2173 513.2 2.9e-145 NP_001345 (OMIM: 600450,614279) aldo-keto reductas ( 323) 2123 501.6 9.1e-142 NP_995317 (OMIM: 600450,614279) aldo-keto reductas ( 323) 2123 501.6 9.1e-142 NP_003730 (OMIM: 603966) aldo-keto reductase famil ( 323) 1927 456.1 4.5e-128 NP_001240837 (OMIM: 603966) aldo-keto reductase fa ( 323) 1923 455.1 8.6e-128 NP_001809 (OMIM: 600451,614279) aldo-keto reductas ( 323) 1845 437.0 2.4e-122 NP_005980 (OMIM: 235555,604741) 3-oxo-5-beta-stero ( 326) 1321 315.4 1e-85 XP_016871280 (OMIM: 600449) PREDICTED: aldo-keto r ( 297) 1185 283.8 3.1e-76 NP_001177836 (OMIM: 235555,604741) 3-oxo-5-beta-st ( 290) 1171 280.5 2.8e-75 NP_001307956 (OMIM: 600450,614279) aldo-keto reduc ( 297) 1165 279.1 7.6e-75 NP_001619 (OMIM: 103880) aldose reductase isoform ( 316) 1069 256.9 4.1e-68 NP_064695 (OMIM: 604707) aldo-keto reductase famil ( 316) 1008 242.7 7.5e-64 XP_011514543 (OMIM: 616336) PREDICTED: aldo-keto r ( 316) 971 234.1 2.9e-61 XP_016867713 (OMIM: 616336) PREDICTED: aldo-keto r ( 344) 946 228.3 1.7e-59 NP_001074007 (OMIM: 616336) aldo-keto reductase fa ( 344) 946 228.3 1.7e-59 NP_001189343 (OMIM: 103830) alcohol dehydrogenase ( 325) 922 222.8 7.9e-58 NP_697021 (OMIM: 103830) alcohol dehydrogenase [NA ( 325) 922 222.8 7.9e-58 NP_006057 (OMIM: 103830) alcohol dehydrogenase [NA ( 325) 922 222.8 7.9e-58 NP_001189342 (OMIM: 103830) alcohol dehydrogenase ( 325) 922 222.8 7.9e-58 NP_001128713 (OMIM: 600450,614279) aldo-keto reduc ( 139) 788 191.4 9.3e-49 NP_001240838 (OMIM: 603966) aldo-keto reductase fa ( 138) 728 177.5 1.4e-44 XP_011514718 (OMIM: 604707) PREDICTED: aldo-keto r ( 277) 665 163.0 6.3e-40 NP_001333071 (OMIM: 103880) aldose reductase isofo ( 172) 597 147.1 2.5e-35 XP_005250291 (OMIM: 103880) PREDICTED: aldose redu ( 172) 597 147.1 2.5e-35 NP_001177835 (OMIM: 235555,604741) 3-oxo-5-beta-st ( 285) 585 144.5 2.5e-34 XP_011538794 (OMIM: 103830) PREDICTED: alcohol deh ( 214) 562 139.1 8.2e-33 XP_011538793 (OMIM: 103830) PREDICTED: alcohol deh ( 214) 562 139.1 8.2e-33 XP_011514719 (OMIM: 604707) PREDICTED: aldo-keto r ( 175) 420 106.0 5.8e-23 NP_036199 (OMIM: 608477) aflatoxin B1 aldehyde red ( 331) 176 49.6 1.1e-05 XP_011539348 (OMIM: 608477) PREDICTED: aflatoxin B ( 375) 176 49.6 1.2e-05 NP_003680 (OMIM: 603418) aflatoxin B1 aldehyde red ( 359) 163 46.6 9.4e-05 XP_016856203 (OMIM: 608477) PREDICTED: aflatoxin B ( 304) 139 41.0 0.0039 NP_001307908 (OMIM: 603418) aflatoxin B1 aldehyde ( 324) 136 40.3 0.0067 >>NP_001344 (OMIM: 600449) aldo-keto reductase family 1 (323 aa) initn: 2173 init1: 2173 opt: 2173 Z-score: 2728.9 bits: 513.2 E(85289): 2.9e-145 Smith-Waterman score: 2173; 100.0% identity (100.0% similar) in 323 aa overlap (1-323:1-323) 10 20 30 40 50 60 pF1KE4 MDSKYQCVKLNDGHFMPVLGFGTYAPAEVPKSKALEATKLAIEAGFRHIDSAHLYNNEEQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MDSKYQCVKLNDGHFMPVLGFGTYAPAEVPKSKALEATKLAIEAGFRHIDSAHLYNNEEQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 VGLAIRSKIADGSVKREDIFYTSKLWCNSHRPELVRPALERSLKNLQLDYVDLYLIHFPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VGLAIRSKIADGSVKREDIFYTSKLWCNSHRPELVRPALERSLKNLQLDYVDLYLIHFPV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 SVKPGEEVIPKDENGKILFDTVDLCATWEAVEKCKDAGLAKSIGVSNFNRRQLEMILNKP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SVKPGEEVIPKDENGKILFDTVDLCATWEAVEKCKDAGLAKSIGVSNFNRRQLEMILNKP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 GLKYKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHREEPWVDPNSPVLLEDPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GLKYKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHREEPWVDPNSPVLLEDPV 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 LCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLN 250 260 270 280 290 300 310 320 pF1KE4 RNVRYLTLDIFAGPPNYPFSDEY ::::::::::::::::::::::: NP_001 RNVRYLTLDIFAGPPNYPFSDEY 310 320 >>NP_001345 (OMIM: 600450,614279) aldo-keto reductase fa (323 aa) initn: 2123 init1: 2123 opt: 2123 Z-score: 2666.2 bits: 501.6 E(85289): 9.1e-142 Smith-Waterman score: 2123; 97.8% identity (99.4% similar) in 323 aa overlap (1-323:1-323) 10 20 30 40 50 60 pF1KE4 MDSKYQCVKLNDGHFMPVLGFGTYAPAEVPKSKALEATKLAIEAGFRHIDSAHLYNNEEQ :::::::::::::::::::::::::::::::::::::.::::::::.::::::.:::::: NP_001 MDSKYQCVKLNDGHFMPVLGFGTYAPAEVPKSKALEAVKLAIEAGFHHIDSAHVYNNEEQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 VGLAIRSKIADGSVKREDIFYTSKLWCNSHRPELVRPALERSLKNLQLDYVDLYLIHFPV :::::::::::::::::::::::::: ::::::::::::::::::::::::::::::::: NP_001 VGLAIRSKIADGSVKREDIFYTSKLWSNSHRPELVRPALERSLKNLQLDYVDLYLIHFPV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 SVKPGEEVIPKDENGKILFDTVDLCATWEAVEKCKDAGLAKSIGVSNFNRRQLEMILNKP ::::::::::::::::::::::::::::::.::::::::::::::::::.: :::::::: NP_001 SVKPGEEVIPKDENGKILFDTVDLCATWEAMEKCKDAGLAKSIGVSNFNHRLLEMILNKP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 GLKYKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHREEPWVDPNSPVLLEDPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GLKYKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHREEPWVDPNSPVLLEDPV 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 LCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLN 250 260 270 280 290 300 310 320 pF1KE4 RNVRYLTLDIFAGPPNYPFSDEY ::::::::::::::::::::::: NP_001 RNVRYLTLDIFAGPPNYPFSDEY 310 320 >>NP_995317 (OMIM: 600450,614279) aldo-keto reductase fa (323 aa) initn: 2123 init1: 2123 opt: 2123 Z-score: 2666.2 bits: 501.6 E(85289): 9.1e-142 Smith-Waterman score: 2123; 97.8% identity (99.4% similar) in 323 aa overlap (1-323:1-323) 10 20 30 40 50 60 pF1KE4 MDSKYQCVKLNDGHFMPVLGFGTYAPAEVPKSKALEATKLAIEAGFRHIDSAHLYNNEEQ :::::::::::::::::::::::::::::::::::::.::::::::.::::::.:::::: NP_995 MDSKYQCVKLNDGHFMPVLGFGTYAPAEVPKSKALEAVKLAIEAGFHHIDSAHVYNNEEQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 VGLAIRSKIADGSVKREDIFYTSKLWCNSHRPELVRPALERSLKNLQLDYVDLYLIHFPV :::::::::::::::::::::::::: ::::::::::::::::::::::::::::::::: NP_995 VGLAIRSKIADGSVKREDIFYTSKLWSNSHRPELVRPALERSLKNLQLDYVDLYLIHFPV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 SVKPGEEVIPKDENGKILFDTVDLCATWEAVEKCKDAGLAKSIGVSNFNRRQLEMILNKP ::::::::::::::::::::::::::::::.::::::::::::::::::.: :::::::: NP_995 SVKPGEEVIPKDENGKILFDTVDLCATWEAMEKCKDAGLAKSIGVSNFNHRLLEMILNKP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 GLKYKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHREEPWVDPNSPVLLEDPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_995 GLKYKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHREEPWVDPNSPVLLEDPV 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 LCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_995 LCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLN 250 260 270 280 290 300 310 320 pF1KE4 RNVRYLTLDIFAGPPNYPFSDEY ::::::::::::::::::::::: NP_995 RNVRYLTLDIFAGPPNYPFSDEY 310 320 >>NP_003730 (OMIM: 603966) aldo-keto reductase family 1 (323 aa) initn: 1927 init1: 1927 opt: 1927 Z-score: 2420.2 bits: 456.1 E(85289): 4.5e-128 Smith-Waterman score: 1927; 87.9% identity (95.7% similar) in 323 aa overlap (1-323:1-323) 10 20 30 40 50 60 pF1KE4 MDSKYQCVKLNDGHFMPVLGFGTYAPAEVPKSKALEATKLAIEAGFRHIDSAHLYNNEEQ ::::.::::::::::::::::::::: :::.:::::.::::::::::::::::::::::: NP_003 MDSKHQCVKLNDGHFMPVLGFGTYAPPEVPRSKALEVTKLAIEAGFRHIDSAHLYNNEEQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 VGLAIRSKIADGSVKREDIFYTSKLWCNSHRPELVRPALERSLKNLQLDYVDLYLIHFPV :::::::::::::::::::::::::: . ::::::::::: :::. ::::::::::: :. NP_003 VGLAIRSKIADGSVKREDIFYTSKLWSTFHRPELVRPALENSLKKAQLDYVDLYLIHSPM 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 SVKPGEEVIPKDENGKILFDTVDLCATWEAVEKCKDAGLAKSIGVSNFNRRQLEMILNKP :.:::::. : :::::..:: ::::.::::.::::::::::::::::::::::::::::: NP_003 SLKPGEELSPTDENGKVIFDIVDLCTTWEAMEKCKDAGLAKSIGVSNFNRRQLEMILNKP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 GLKYKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHREEPWVDPNSPVLLEDPV ::::::::::::::::::. :::::::::::::::::::::.:.. :::::::::::::: NP_003 GLKYKPVCNQVECHPYFNRSKLLDFCKSKDIVLVAYSALGSQRDKRWVDPNSPVLLEDPV 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 LCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLN :::::::::::::::::::::::::::::::::::::::::::::::::.:.:::::::. NP_003 LCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTAEDMKAIDGLD 250 260 270 280 290 300 310 320 pF1KE4 RNVRYLTLDIFAGPPNYPFSDEY ::..:.. : ::. ::::.:::: NP_003 RNLHYFNSDSFASHPNYPYSDEY 310 320 >>NP_001240837 (OMIM: 603966) aldo-keto reductase family (323 aa) initn: 1923 init1: 1923 opt: 1923 Z-score: 2415.2 bits: 455.1 E(85289): 8.6e-128 Smith-Waterman score: 1923; 87.6% identity (95.7% similar) in 323 aa overlap (1-323:1-323) 10 20 30 40 50 60 pF1KE4 MDSKYQCVKLNDGHFMPVLGFGTYAPAEVPKSKALEATKLAIEAGFRHIDSAHLYNNEEQ ::::.::.:::::::::::::::::: :::.:::::.::::::::::::::::::::::: NP_001 MDSKHQCLKLNDGHFMPVLGFGTYAPPEVPRSKALEVTKLAIEAGFRHIDSAHLYNNEEQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 VGLAIRSKIADGSVKREDIFYTSKLWCNSHRPELVRPALERSLKNLQLDYVDLYLIHFPV :::::::::::::::::::::::::: . ::::::::::: :::. ::::::::::: :. NP_001 VGLAIRSKIADGSVKREDIFYTSKLWSTFHRPELVRPALENSLKKAQLDYVDLYLIHSPM 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 SVKPGEEVIPKDENGKILFDTVDLCATWEAVEKCKDAGLAKSIGVSNFNRRQLEMILNKP :.:::::. : :::::..:: ::::.::::.::::::::::::::::::::::::::::: NP_001 SLKPGEELSPTDENGKVIFDIVDLCTTWEAMEKCKDAGLAKSIGVSNFNRRQLEMILNKP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 GLKYKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHREEPWVDPNSPVLLEDPV ::::::::::::::::::. :::::::::::::::::::::.:.. :::::::::::::: NP_001 GLKYKPVCNQVECHPYFNRSKLLDFCKSKDIVLVAYSALGSQRDKRWVDPNSPVLLEDPV 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 LCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLN :::::::::::::::::::::::::::::::::::::::::::::::::.:.:::::::. NP_001 LCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTAEDMKAIDGLD 250 260 270 280 290 300 310 320 pF1KE4 RNVRYLTLDIFAGPPNYPFSDEY ::..:.. : ::. ::::.:::: NP_001 RNLHYFNSDSFASHPNYPYSDEY 310 320 >>NP_001809 (OMIM: 600451,614279) aldo-keto reductase fa (323 aa) initn: 1845 init1: 1845 opt: 1845 Z-score: 2317.4 bits: 437.0 E(85289): 2.4e-122 Smith-Waterman score: 1845; 83.0% identity (95.0% similar) in 323 aa overlap (1-323:1-323) 10 20 30 40 50 60 pF1KE4 MDSKYQCVKLNDGHFMPVLGFGTYAPAEVPKSKALEATKLAIEAGFRHIDSAHLYNNEEQ :: ::: :.::::::::::::::::: :::...:.:.:::::::::::::::.::::::: NP_001 MDPKYQRVELNDGHFMPVLGFGTYAPPEVPRNRAVEVTKLAIEAGFRHIDSAYLYNNEEQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 VGLAIRSKIADGSVKREDIFYTSKLWCNSHRPELVRPALERSLKNLQLDYVDLYLIHFPV :::::::::::::::::::::::::::. .:..:.:::: :::.::::::::::.:::. NP_001 VGLAIRSKIADGSVKREDIFYTSKLWCTFFQPQMVQPALESSLKKLQLDYVDLYLLHFPM 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 SVKPGEEVIPKDENGKILFDTVDLCATWEAVEKCKDAGLAKSIGVSNFNRRQLEMILNKP ..:::: .:::::::..:::::: ::::..:::::::::::::::::: :::::::::: NP_001 ALKPGETPLPKDENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFNCRQLEMILNKP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 GLKYKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHREEPWVDPNSPVLLEDPV ::::::::::::::::.:: :::::::::::::::.::::..:.. :::::::::::::: NP_001 GLKYKPVCNQVECHPYLNQSKLLDFCKSKDIVLVAHSALGTQRHKLWVDPNSPVLLEDPV 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 LCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLN ::::::::::::::::::::::::::::::::::::::.:.::::::::::.::..:::: NP_001 LCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRENIQVFEFQLTSEDMKVLDGLN 250 260 270 280 290 300 310 320 pF1KE4 RNVRYLTLDIFAGPPNYPFSDEY :: ::...:.. :.::::::: NP_001 RNYRYVVMDFLMDHPDYPFSDEY 310 320 >>NP_005980 (OMIM: 235555,604741) 3-oxo-5-beta-steroid 4 (326 aa) initn: 1310 init1: 1261 opt: 1321 Z-score: 1659.8 bits: 315.4 E(85289): 1e-85 Smith-Waterman score: 1321; 58.7% identity (85.2% similar) in 317 aa overlap (8-323:10-326) 10 20 30 40 50 pF1KE4 MDSKYQCVKLNDGHFMPVLGFGTYA-PAEVPKSKALEATKLAIEAGFRHIDSAHLYNN . :.::. .:..:.:::. : .::. ..:.::..:.::::.:..:.: NP_005 MDLSAASHRIPLSDGNSIPIIGLGTYSEPKSTPKGACATSVKVAIDTGYRHIDGAYIYQN 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE4 EEQVGLAIRSKIADGSVKREDIFYTSKLWCNSHRPELVRPALERSLKNLQLDYVDLYLIH :..:: ::: :::.:.:.:::::: .::: ..: ::.:::.:::.:. :::::::::.:. NP_005 EHEVGEAIREKIAEGKVRREDIFYCGKLWATNHVPEMVRPTLERTLRVLQLDYVDLYIIE 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE4 FPVSVKPGEEVIPKDENGKILFDTVDLCATWEAVEKCKDAGLAKSIGVSNFNRRQLEMIL :.. :::.:. :.::::: :. .:::::::.: ::::::.::.:::::::::::.:: NP_005 VPMAFKPGDEIYPRDENGKWLYHKSNLCATWEAMEACKDAGLVKSLGVSNFNRRQLELIL 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE4 NKPGLKYKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHREEPWVDPNSPVLLE ::::::.::: :::::::::.: ::: ::...:::..::: ::. :. ::. .:: ::. NP_005 NKPGLKHKPVSNQVECHPYFTQPKLLKFCQQHDIVITAYSPLGTSRNPIWVNVSSPPLLK 190 200 210 220 230 240 240 250 260 270 280 290 pF1KE4 DPVLCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAID : .: .:.:....: : :.::...::::::. ::.: .::..: :.:.:.:: :::: :. NP_005 DALLNSLGKRYNKTAAQIVLRFNIQRGVVVIPKSFNLERIKENFQIFDFSLTEEEMKDIE 250 260 270 280 290 300 300 310 320 pF1KE4 GLNRNVRYLTLDIFAGPPNYPFSDEY .::.:::.. : .. :.::: ::: NP_005 ALNKNVRFVELLMWRDHPEYPFHDEY 310 320 >>XP_016871280 (OMIM: 600449) PREDICTED: aldo-keto reduc (297 aa) initn: 1172 init1: 1172 opt: 1185 Z-score: 1489.8 bits: 283.8 E(85289): 3.1e-76 Smith-Waterman score: 1927; 92.0% identity (92.0% similar) in 323 aa overlap (1-323:1-297) 10 20 30 40 50 60 pF1KE4 MDSKYQCVKLNDGHFMPVLGFGTYAPAEVPKSKALEATKLAIEAGFRHIDSAHLYNNEEQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MDSKYQCVKLNDGHFMPVLGFGTYAPAEVPKSKALEATKLAIEAGFRHIDSAHLYNNEEQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 VGLAIRSKIADGSVKREDIFYTSKLWCNSHRPELVRPALERSLKNLQLDYVDLYLIHFPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VGLAIRSKIADGSVKREDIFYTSKLWCNSHRPELVRPALERSLKNLQLDYVDLYLIHFPV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 SVKPGEEVIPKDENGKILFDTVDLCATWEAVEKCKDAGLAKSIGVSNFNRRQLEMILNKP ::: ::::::::::::::::::::::::::::::: XP_016 SVK--------------------------AVEKCKDAGLAKSIGVSNFNRRQLEMILNKP 130 140 150 190 200 210 220 230 240 pF1KE4 GLKYKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHREEPWVDPNSPVLLEDPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GLKYKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHREEPWVDPNSPVLLEDPV 160 170 180 190 200 210 250 260 270 280 290 300 pF1KE4 LCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLN 220 230 240 250 260 270 310 320 pF1KE4 RNVRYLTLDIFAGPPNYPFSDEY ::::::::::::::::::::::: XP_016 RNVRYLTLDIFAGPPNYPFSDEY 280 290 >>NP_001177836 (OMIM: 235555,604741) 3-oxo-5-beta-steroi (290 aa) initn: 1160 init1: 1111 opt: 1171 Z-score: 1472.4 bits: 280.5 E(85289): 2.8e-75 Smith-Waterman score: 1171; 59.6% identity (85.9% similar) in 277 aa overlap (8-283:10-286) 10 20 30 40 50 pF1KE4 MDSKYQCVKLNDGHFMPVLGFGTYA-PAEVPKSKALEATKLAIEAGFRHIDSAHLYNN . :.::. .:..:.:::. : .::. ..:.::..:.::::.:..:.: NP_001 MDLSAASHRIPLSDGNSIPIIGLGTYSEPKSTPKGACATSVKVAIDTGYRHIDGAYIYQN 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE4 EEQVGLAIRSKIADGSVKREDIFYTSKLWCNSHRPELVRPALERSLKNLQLDYVDLYLIH :..:: ::: :::.:.:.:::::: .::: ..: ::.:::.:::.:. :::::::::.:. NP_001 EHEVGEAIREKIAEGKVRREDIFYCGKLWATNHVPEMVRPTLERTLRVLQLDYVDLYIIE 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE4 FPVSVKPGEEVIPKDENGKILFDTVDLCATWEAVEKCKDAGLAKSIGVSNFNRRQLEMIL :.. :::.:. :.::::: :. .:::::::.: ::::::.::.:::::::::::.:: NP_001 VPMAFKPGDEIYPRDENGKWLYHKSNLCATWEAMEACKDAGLVKSLGVSNFNRRQLELIL 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE4 NKPGLKYKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHREEPWVDPNSPVLLE ::::::.::: :::::::::.: ::: ::...:::..::: ::. :. ::. .:: ::. NP_001 NKPGLKHKPVSNQVECHPYFTQPKLLKFCQQHDIVITAYSPLGTSRNPIWVNVSSPPLLK 190 200 210 220 230 240 240 250 260 270 280 290 pF1KE4 DPVLCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAID : .: .:.:....: : :.::...::::::. ::.: .::..: :: NP_001 DALLNSLGKRYNKTAAQIVLRFNIQRGVVVIPKSFNLERIKENFQVARSS 250 260 270 280 290 300 310 320 pF1KE4 GLNRNVRYLTLDIFAGPPNYPFSDEY >>NP_001307956 (OMIM: 600450,614279) aldo-keto reductase (297 aa) initn: 1152 init1: 1152 opt: 1165 Z-score: 1464.7 bits: 279.1 E(85289): 7.6e-75 Smith-Waterman score: 1877; 89.8% identity (91.3% similar) in 323 aa overlap (1-323:1-297) 10 20 30 40 50 60 pF1KE4 MDSKYQCVKLNDGHFMPVLGFGTYAPAEVPKSKALEATKLAIEAGFRHIDSAHLYNNEEQ :::::::::::::::::::::::::::::::::::::.::::::::.::::::.:::::: NP_001 MDSKYQCVKLNDGHFMPVLGFGTYAPAEVPKSKALEAVKLAIEAGFHHIDSAHVYNNEEQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 VGLAIRSKIADGSVKREDIFYTSKLWCNSHRPELVRPALERSLKNLQLDYVDLYLIHFPV :::::::::::::::::::::::::: ::::::::::::::::::::::::::::::::: NP_001 VGLAIRSKIADGSVKREDIFYTSKLWSNSHRPELVRPALERSLKNLQLDYVDLYLIHFPV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 SVKPGEEVIPKDENGKILFDTVDLCATWEAVEKCKDAGLAKSIGVSNFNRRQLEMILNKP ::: :.::::::::::::::::::.: :::::::: NP_001 SVK--------------------------AMEKCKDAGLAKSIGVSNFNHRLLEMILNKP 130 140 150 190 200 210 220 230 240 pF1KE4 GLKYKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHREEPWVDPNSPVLLEDPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GLKYKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHREEPWVDPNSPVLLEDPV 160 170 180 190 200 210 250 260 270 280 290 300 pF1KE4 LCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLN 220 230 240 250 260 270 310 320 pF1KE4 RNVRYLTLDIFAGPPNYPFSDEY ::::::::::::::::::::::: NP_001 RNVRYLTLDIFAGPPNYPFSDEY 280 290 323 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 23:13:36 2016 done: Sat Nov 5 23:13:37 2016 Total Scan time: 7.350 Total Display time: 0.040 Function used was FASTA [36.3.4 Apr, 2011]