Result of FASTA (omim) for
pFN21AB6168
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB6168, 603 aa
1>>>pF1KB6168 603 - 603 aa - 603 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 9.3869+/-0.000531; mu= 1.1078+/- 0.032
mean_var=557.1001+/-126.461, 0's: 0 Z-trim(117.6): 1873 B-trim: 0 in 0/57
Lambda= 0.054338
statistics sampled from 27103 (29708) to 27103 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.69), E-opt: 0.2 (0.348), width: 16
Scan time: 7.720
The best scores are: opt bits E(85289)
NP_005021 (OMIM: 602098) serine/threonine-protein ( 603) 4020 331.2 6.3e-90
NP_004064 (OMIM: 602913) serine/threonine-protein ( 646) 1146 105.9 4.3e-22
NP_001239155 (OMIM: 607023) serine/threonine-prote ( 671) 1131 104.8 1e-21
NP_006613 (OMIM: 607023) serine/threonine-protein ( 685) 1125 104.3 1.4e-21
XP_005262758 (OMIM: 605031,616171) PREDICTED: seri ( 936) 687 70.2 3.6e-11
XP_016863152 (OMIM: 605031,616171) PREDICTED: seri ( 937) 687 70.2 3.6e-11
NP_055079 (OMIM: 605031,616171) serine/threonine-p ( 970) 687 70.2 3.6e-11
XP_016863151 (OMIM: 605031,616171) PREDICTED: seri ( 971) 687 70.2 3.6e-11
NP_001177730 (OMIM: 605031,616171) serine/threonin ( 929) 639 66.4 4.8e-10
NP_001177728 (OMIM: 605031,616171) serine/threonin ( 938) 594 62.9 5.6e-09
NP_940839 (OMIM: 603072) aurora kinase A [Homo sap ( 403) 558 59.5 2.6e-08
NP_001310233 (OMIM: 603072) aurora kinase A [Homo ( 403) 558 59.5 2.6e-08
NP_940836 (OMIM: 603072) aurora kinase A [Homo sap ( 403) 558 59.5 2.6e-08
NP_940835 (OMIM: 603072) aurora kinase A [Homo sap ( 403) 558 59.5 2.6e-08
NP_940838 (OMIM: 603072) aurora kinase A [Homo sap ( 403) 558 59.5 2.6e-08
NP_003591 (OMIM: 603072) aurora kinase A [Homo sap ( 403) 558 59.5 2.6e-08
NP_001310234 (OMIM: 603072) aurora kinase A [Homo ( 403) 558 59.5 2.6e-08
NP_001310232 (OMIM: 603072) aurora kinase A [Homo ( 403) 558 59.5 2.6e-08
XP_016883524 (OMIM: 603072) PREDICTED: aurora kina ( 403) 558 59.5 2.6e-08
NP_940837 (OMIM: 603072) aurora kinase A [Homo sap ( 403) 558 59.5 2.6e-08
XP_016883523 (OMIM: 603072) PREDICTED: aurora kina ( 437) 558 59.5 2.7e-08
XP_011527839 (OMIM: 606532) PREDICTED: hormonally ( 698) 543 58.7 7.7e-08
NP_055401 (OMIM: 606532) hormonally up-regulated n ( 714) 543 58.7 7.8e-08
NP_055655 (OMIM: 608130) NUAK family SNF1-like kin ( 661) 534 58.0 1.2e-07
XP_005267700 (OMIM: 602678) PREDICTED: MAP/microtu ( 643) 519 56.8 2.7e-07
XP_016876782 (OMIM: 602678) PREDICTED: MAP/microtu ( 708) 519 56.8 2.8e-07
NP_001122392 (OMIM: 602678) MAP/microtubule affini ( 713) 519 56.8 2.9e-07
XP_016876781 (OMIM: 602678) PREDICTED: MAP/microtu ( 722) 519 56.8 2.9e-07
XP_016876780 (OMIM: 602678) PREDICTED: MAP/microtu ( 728) 519 56.8 2.9e-07
NP_002367 (OMIM: 602678) MAP/microtubule affinity- ( 729) 519 56.8 2.9e-07
XP_005267699 (OMIM: 602678) PREDICTED: MAP/microtu ( 737) 519 56.9 2.9e-07
XP_005267698 (OMIM: 602678) PREDICTED: MAP/microtu ( 738) 519 56.9 2.9e-07
XP_006720209 (OMIM: 602678) PREDICTED: MAP/microtu ( 739) 519 56.9 2.9e-07
NP_001122391 (OMIM: 602678) MAP/microtubule affini ( 744) 519 56.9 2.9e-07
NP_001122390 (OMIM: 602678) MAP/microtubule affini ( 753) 519 56.9 2.9e-07
XP_011541028 (OMIM: 614776) PREDICTED: serine/thre ( 660) 517 56.6 3.1e-07
NP_001273055 (OMIM: 606511) serine/threonine-prote ( 780) 513 56.4 4.1e-07
XP_005273191 (OMIM: 606511) PREDICTED: serine/thre ( 781) 513 56.4 4.1e-07
XP_011507863 (OMIM: 606511) PREDICTED: serine/thre ( 788) 513 56.4 4.2e-07
XP_016872913 (OMIM: 614776) PREDICTED: serine/thre (1213) 517 57.1 4.2e-07
NP_061120 (OMIM: 606511) serine/threonine-protein ( 795) 513 56.4 4.2e-07
NP_001273053 (OMIM: 606511) serine/threonine-prote ( 796) 513 56.4 4.2e-07
XP_005271541 (OMIM: 614776) PREDICTED: serine/thre (1261) 517 57.1 4.3e-07
NP_001268678 (OMIM: 614776) serine/threonine-prote (1261) 517 57.1 4.3e-07
XP_011541024 (OMIM: 614776) PREDICTED: serine/thre (1309) 517 57.1 4.3e-07
XP_005271539 (OMIM: 614776) PREDICTED: serine/thre (1321) 517 57.1 4.4e-07
NP_079440 (OMIM: 614776) serine/threonine-protein (1321) 517 57.1 4.4e-07
NP_001156769 (OMIM: 600526) serine/threonine-prote ( 709) 511 56.2 4.4e-07
NP_001156768 (OMIM: 600526) serine/threonine-prote ( 719) 511 56.2 4.4e-07
XP_005271538 (OMIM: 614776) PREDICTED: serine/thre (1369) 517 57.1 4.4e-07
>>NP_005021 (OMIM: 602098) serine/threonine-protein kina (603 aa)
initn: 4020 init1: 4020 opt: 4020 Z-score: 1735.5 bits: 331.2 E(85289): 6.3e-90
Smith-Waterman score: 4020; 100.0% identity (100.0% similar) in 603 aa overlap (1-603:1-603)
10 20 30 40 50 60
pF1KB6 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB6 KGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 KGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFF
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB6 EDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 EDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLG
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB6 NLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 NLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCI
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB6 MYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 MYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELL
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB6 NDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 NDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEE
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB6 PVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 PVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDK
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB6 YGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 YGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLK
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB6 YFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 YFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTK
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB6 LILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 LILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRL
550 560 570 580 590 600
pF1KB6 KAS
:::
NP_005 KAS
>>NP_004064 (OMIM: 602913) serine/threonine-protein kina (646 aa)
initn: 1380 init1: 1100 opt: 1146 Z-score: 517.6 bits: 105.9 E(85289): 4.3e-22
Smith-Waterman score: 1526; 40.7% identity (65.7% similar) in 632 aa overlap (9-589:15-643)
10 20 30 40 50
pF1KB6 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPA---AAPPAKEIPEVLVDPRSRR
. : ::: :. : : : : :. :... ....:::: :
NP_004 MEPAAGFLSPRPFQRAAAAPAPPAGPGPPPSALRGPELEMLAGLPTSDPGRLITDPRSGR
10 20 30 40 50 60
60 70 80 90 100 110
pF1KB6 RYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQ
:..::.:::::::.:.: .:..: ..: :..:.: . :::::::. :: .::.: :.
NP_004 TYLKGRLLGKGGFARCYEATDTETGSAYAVKVIPQSRVAKPHQREKILNEIELHRDLQHR
70 80 90 100 110 120
120 130 140 150 160 170
pF1KB6 HVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNR
:.: : ::: : ... :::: :.:: .. : :..: :::.:::::::. : .:::.
NP_004 HIVRFSHHFEDADNIYIFLELCSRKSLAHIWKARHTLLEPEVRYYLRQILSGLKYLHQRG
130 140 150 160 170 180
180 190 200 210 220 230
pF1KB6 VIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFE
..::::::::.:..:..:.:.::::::...: .::::.::::::.::::: ..::. :
NP_004 ILHRDLKLGNFFITENMELKVGDFGLAARLEPPEQRKKTICGTPNYVAPEVLLRQGHGPE
190 200 210 220 230 240
240 250 260 270 280 290
pF1KB6 VDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPT
.::::.::.::::: :.:::::. ::::: ::. .:..: .. : .:. .:...:
NP_004 ADVWSLGCVMYTLLCGSPPFETADLKETYRCIKQVHYTLPASLSLPARQLLAAILRASPR
250 260 270 280 290 300
300 310 320 330 340
pF1KB6 ARPTINELLNDEFFTSGYIPARLPIT-CLTIPPRFSIAPS-SLDPSNRKPLTVLNKGLEN
::.:...: .:::.:: : ::::. :.:.: :. :: . : : .: .:
NP_004 DRPSIDQILRHDFFTKGYTPDRLPISSCVTVPDLTPPNPARSLFAKVTKSLFGRKKKSKN
310 320 330 340 350 360
350 360 370 380
pF1KB6 PLPERPR------------------EKEEPVVRETGEV--VDCHLSDMLQQLHSVNASKP
:: . . : :.. . : :. : . ....
NP_004 HAQERDEVSGLVSGLMRTSVGHQDARPEAPAASGPAPVSLVETAPEDSSPRGTLASSGDG
370 380 390 400 410 420
390 400 410 420
pF1KB6 SERGLVRQEEAEDPACI----------------------PIFWVSKWVDYSDKYGLGYQL
:.::. .:. : :. :::::::::.:.:.::::
NP_004 FEEGLTVATVVESALCALRNCIAFMPPAEQNPAPLAQPEPLVWVSKWVDYSNKFGFGYQL
430 440 450 460 470 480
430 440 450 460 470 480
pF1KB6 CDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMS
. :.:::::.:.. : . ...: . . ..:.. : .:. .. .:.:: .::
NP_004 SSRRVAVLFNDGTHMALSANRKTVHYNPTSTKHFSFSVGAVPRALQPQLGILRYFASYME
490 500 510 520 530 540
490 500 510 520 530 540
pF1KB6 EHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILC---
.::.:.: .. : :. : : : .: .:... .:.:.::.::. :::::::
NP_004 QHLMKGG-DLPSVEEVEVPAPPLLLQWVKTDQALLMLFSDGTVQVNFYGDHTKLILSGWE
550 560 570 580 590
550 560 570 580 590 600
pF1KB6 PLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYA-RTMVDKLLSSRSASNRLKAS
::. ::.. ..:. :: : :.. :: .: .::::: : . :.
NP_004 PLL--VTFVARNRSACTYLASHLRQLGCSPDLRQRLRYALRLLRDRSPA
600 610 620 630 640
>>NP_001239155 (OMIM: 607023) serine/threonine-protein k (671 aa)
initn: 1493 init1: 1081 opt: 1131 Z-score: 511.0 bits: 104.8 E(85289): 1e-21
Smith-Waterman score: 1469; 38.9% identity (65.9% similar) in 628 aa overlap (12-571:33-650)
10 20 30 40
pF1KB6 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIP
. : .: . . : : . : .::: :
NP_001 LLRTITYQPAASTKMCEQALGKGCGADSKKKRPPQPPEESQP----PQSQAQVPPA--IS
10 20 30 40 50
50 60 70 80 90 100
pF1KB6 EVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSME
...::: . .:: ::. :::::::::.:..: ...:.:.::.:.: . :::::::.. :
NP_001 RIIVDPTTGKRYCRGKVLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVAKPHQREKIDKE
60 70 80 90 100 110
110 120 130 140 150 160
pF1KB6 ISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIV
: .:: : :.::: :. .:::.. ....:: : :::. .. : ::.:::::.::::::::
NP_001 IELHRILHHKHVVQFYHYFEDKENIYILLEYCSRRSMAHILKARKVLTEPEVRYYLRQIV
120 130 140 150 160 170
170 180 190 200 210 220
pF1KB6 LGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPE
: .:::.....::::::::.:.:: .:.:.::::::...: .:..:.::::::..::
NP_001 SGLKYLHEQEILHRDLKLGNFFINEAMELKVGDFGLAARLEPLEHRRRTICGTPNYLSPE
180 190 200 210 220 230
230 240 250 260 270 280
pF1KB6 VLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASL
::.:.::. : :.:..::.:::.:.:.:::::. ::::: :.. .:..:. . : :
NP_001 VLNKQGHGCESDIWALGCVMYTMLLGRPPFETTNLKETYRCIREARYTMPSSLLAPAKHL
240 250 260 270 280 290
290 300 310 320 330
pF1KB6 IQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIA-PSS---------
: .::. .: ::...... .:: .:. : :: .: : : .. :..
NP_001 IASMLSKNPEDRPSLDDIIRHDFFLQGFTPDRLSSSCCHTVPDFHLSSPAKNFFKKAAAA
300 310 320 330 340 350
340 350 360
pF1KB6 -----------LDPSNR-----KPLTVLNKGL------ENPLPERPREKEEP----VVRE
.: :: . . : . : ..: .: :. .: :.:
NP_001 LFGGKKDKARYIDTHNRVSKEDEDIYKLRHDLKKTSITQQPSKHRTDEELQPPTTTVARS
360 370 380 390 400 410
370 380 390 400
pF1KB6 TGEVVDC--HLSDMLQQ-----LHSVNAS----KPSERGLVRQ----------EEAEDPA
.:. ...: ... : : ..: . : : : . :. .
NP_001 GTPAVENKQQIGDAIRMIVRGTLGSCSSSSECLEDSTMGSVADTVARVLRGCLENMPEAD
420 430 440 450 460 470
410 420 430 440 450
pF1KB6 CIP-------IFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERD
::: . ::.::::::.:::.:::: :..::::::..... : : ...: .
NP_001 CIPKEQLSTSFQWVTKWVDYSNKYGFGYQLSDHTVGVLFNNGAHMSLLPDKKTVHYYAEL
480 490 500 510 520 530
460 470 480 490 500 510
pF1KB6 GTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLP--YLRTWF
: : . ... :.......:.:::: .:: :.:. .: : : : : :: :.
NP_001 GQCSVFPATDAPEQFISQVTVLKYFSHYMEENLMDGGD--LPSVTD--IRRPRLYLLQWL
540 550 560 570 580 590
520 530 540 550 560 570
pF1KB6 RTRSAIILHLSNGSVQINFFQDHTKLILCPLMAA--VTYIDEKRDFRTYRLSLLEEYGCC
.. .:... ...:. :.::..::::.:.: .:::.: : :.::. : :
NP_001 KSDKALMMLFNDGTFQVNFYHDHTKIIICSQNEEYLLTYINEDRISTTFRLTTLLMSGCS
600 610 620 630 640 650
580 590 600
pF1KB6 KELASRLRYARTMVDKLLSSRSASNRLKAS
NP_001 SELKNRMEYALNMLLQRCN
660 670
>>NP_006613 (OMIM: 607023) serine/threonine-protein kina (685 aa)
initn: 1511 init1: 1099 opt: 1125 Z-score: 508.4 bits: 104.3 E(85289): 1.4e-21
Smith-Waterman score: 1463; 38.4% identity (65.3% similar) in 636 aa overlap (12-571:33-664)
10 20 30
pF1KB6 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAP------
. : .: . . : . .: :::
NP_006 LLRTITYQPAASTKMCEQALGKGCGADSKKKRPPQPPEESQPPQSQAQVPPAAPHHHHHH
10 20 30 40 50 60
40 50 60 70 80 90
pF1KB6 --PAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPH
. :: ...::: . .:: ::. :::::::::.:..: ...:.:.::.:.: . :::
NP_006 SHSGPEISRIIVDPTTGKRYCRGKVLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVAKPH
70 80 90 100 110 120
100 110 120 130 140 150
pF1KB6 QREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEA
::::.. :: .:: : :.::: :. .:::.. ....:: : :::. .. : ::.:::::.
NP_006 QREKIDKEIELHRILHHKHVVQFYHYFEDKENIYILLEYCSRRSMAHILKARKVLTEPEV
130 140 150 160 170 180
160 170 180 190 200 210
pF1KB6 RYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCG
:::::::: : .:::.....::::::::.:.:: .:.:.::::::...: .:..:.::
NP_006 RYYLRQIVSGLKYLHEQEILHRDLKLGNFFINEAMELKVGDFGLAARLEPLEHRRRTICG
190 200 210 220 230 240
220 230 240 250 260 270
pF1KB6 TPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKH
::::..::::.:.::. : :.:..::.:::.:.:.:::::. ::::: :.. .:..:.
NP_006 TPNYLSPEVLNKQGHGCESDIWALGCVMYTMLLGRPPFETTNLKETYRCIREARYTMPSS
250 260 270 280 290 300
280 290 300 310 320 330
pF1KB6 INPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIA-PSS-
. : :: .::. .: ::...... .:: .:. : :: .: : : .. :..
NP_006 LLAPAKHLIASMLSKNPEDRPSLDDIIRHDFFLQGFTPDRLSSSCCHTVPDFHLSSPAKN
310 320 330 340 350 360
340 350 360
pF1KB6 -------------------LDPSNR-----KPLTVLNKGL------ENPLPERPREKEEP
.: :: . . : . : ..: .: :. .:
NP_006 FFKKAAAALFGGKKDKARYIDTHNRVSKEDEDIYKLRHDLKKTSITQQPSKHRTDEELQP
370 380 390 400 410 420
370 380 390
pF1KB6 ----VVRETGEVVDC--HLSDMLQQ-----LHSVNAS----KPSERGLVRQ---------
:.: .:. ...: ... : : ..: . : : : .
NP_006 PTTTVARSGTPAVENKQQIGDAIRMIVRGTLGSCSSSSECLEDSTMGSVADTVARVLRGC
430 440 450 460 470 480
400 410 420 430 440
pF1KB6 -EEAEDPACIP-------IFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGD
:. . ::: . ::.::::::.:::.:::: :..::::::..... : :
NP_006 LENMPEADCIPKEQLSTSFQWVTKWVDYSNKYGFGYQLSDHTVGVLFNNGAHMSLLPDKK
490 500 510 520 530 540
450 460 470 480 490 500
pF1KB6 SLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLP
...: . : : . ... :.......:.:::: .:: :.:. .: : : : :
NP_006 TVHYYAELGQCSVFPATDAPEQFISQVTVLKYFSHYMEENLMDGGD--LPSVTD--IRRP
550 560 570 580 590
510 520 530 540 550 560
pF1KB6 --YLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAA--VTYIDEKRDFRTYRLS
:: :... .:... ...:. :.::..::::.:.: .:::.: : :.::.
NP_006 RLYLLQWLKSDKALMMLFNDGTFQVNFYHDHTKIIICSQNEEYLLTYINEDRISTTFRLT
600 610 620 630 640 650
570 580 590 600
pF1KB6 LLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS
: :
NP_006 TLLMSGCSSELKNRMEYALNMLLQRCN
660 670 680
>>XP_005262758 (OMIM: 605031,616171) PREDICTED: serine/t (936 aa)
initn: 722 init1: 529 opt: 687 Z-score: 321.6 bits: 70.2 E(85289): 3.6e-11
Smith-Waterman score: 687; 37.7% identity (76.2% similar) in 252 aa overlap (56-306:15-266)
30 40 50 60 70 80
pF1KB6 AAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVP
: .::::.:: .. . : : :..
XP_005 MATCIGEKIEDFKVGNLLGKGSFAGVYRAESIHTGLEVAIKMID
10 20 30 40
90 100 110 120 130 140
pF1KB6 KSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLE-LHKR
:. . : . .... :..:: .: : .. ....:::...:..:::.:. . . :..:
XP_005 KKAMYKAGMVQRVQNEVKIHCQLKHPSILELYNYFEDSNYVYLVLEMCHNGEMNRYLKNR
50 60 70 80 90 100
150 160 170 180 190 200
pF1KB6 RKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYD
: ..: :::....::. : ::: . ..:::: :.::.:......::.::::::....
XP_005 VKPFSENEARHFMHQIITGMLYLHSHGILHRDLTLSNLLLTRNMNIKIADFGLATQLKMP
110 120 130 140 150 160
210 220 230 240 250 260
pF1KB6 GERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIK
:.. :::::::::.::. ....:..: ::::.::..::::.:.:::.:. .:.: ..
XP_005 HEKHYTLCGTPNYISPEIATRSAHGLESDVWSLGCMFYTLLIGRPPFDTDTVKNTLNKVV
170 180 190 200 210 220
270 280 290 300 310 320
pF1KB6 KNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPR
.: .:. .. : .::...:. .:. : ... .:. :..
XP_005 LADYEMPSFLSIEAKDLIHQLLRRNPADRLSLSSVLDHPFMSRNSSTKSKDLGTVEDSID
230 240 250 260 270 280
330 340 350 360 370 380
pF1KB6 FSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSV
XP_005 SGHATISTAITASSSTSISGSLFDKRRLLIGQPLPNKMTVFPKNKSSTDFSSSGDGNSFY
290 300 310 320 330 340
>>XP_016863152 (OMIM: 605031,616171) PREDICTED: serine/t (937 aa)
initn: 722 init1: 529 opt: 687 Z-score: 321.6 bits: 70.2 E(85289): 3.6e-11
Smith-Waterman score: 687; 37.7% identity (76.2% similar) in 252 aa overlap (56-306:16-267)
30 40 50 60 70 80
pF1KB6 AAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVP
: .::::.:: .. . : : :..
XP_016 MPSTLDTCCIEDFKVGNLLGKGSFAGVYRAESIHTGLEVAIKMID
10 20 30 40
90 100 110 120 130 140
pF1KB6 KSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLE-LHKR
:. . : . .... :..:: .: : .. ....:::...:..:::.:. . . :..:
XP_016 KKAMYKAGMVQRVQNEVKIHCQLKHPSILELYNYFEDSNYVYLVLEMCHNGEMNRYLKNR
50 60 70 80 90 100
150 160 170 180 190 200
pF1KB6 RKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYD
: ..: :::....::. : ::: . ..:::: :.::.:......::.::::::....
XP_016 VKPFSENEARHFMHQIITGMLYLHSHGILHRDLTLSNLLLTRNMNIKIADFGLATQLKMP
110 120 130 140 150 160
210 220 230 240 250 260
pF1KB6 GERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIK
:.. :::::::::.::. ....:..: ::::.::..::::.:.:::.:. .:.: ..
XP_016 HEKHYTLCGTPNYISPEIATRSAHGLESDVWSLGCMFYTLLIGRPPFDTDTVKNTLNKVV
170 180 190 200 210 220
270 280 290 300 310 320
pF1KB6 KNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPR
.: .:. .. : .::...:. .:. : ... .:. :..
XP_016 LADYEMPSFLSIEAKDLIHQLLRRNPADRLSLSSVLDHPFMSRNSSTKSKDLGTVEDSID
230 240 250 260 270 280
330 340 350 360 370 380
pF1KB6 FSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSV
XP_016 SGHATISTAITASSSTSISGSLFDKRRLLIGQPLPNKMTVFPKNKSSTDFSSSGDGNSFY
290 300 310 320 330 340
>>NP_055079 (OMIM: 605031,616171) serine/threonine-prote (970 aa)
initn: 683 init1: 529 opt: 687 Z-score: 321.5 bits: 70.2 E(85289): 3.6e-11
Smith-Waterman score: 687; 37.7% identity (76.2% similar) in 252 aa overlap (56-306:15-266)
30 40 50 60 70 80
pF1KB6 AAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVP
: .::::.:: .. . : : :..
NP_055 MATCIGEKIEDFKVGNLLGKGSFAGVYRAESIHTGLEVAIKMID
10 20 30 40
90 100 110 120 130 140
pF1KB6 KSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLE-LHKR
:. . : . .... :..:: .: : .. ....:::...:..:::.:. . . :..:
NP_055 KKAMYKAGMVQRVQNEVKIHCQLKHPSILELYNYFEDSNYVYLVLEMCHNGEMNRYLKNR
50 60 70 80 90 100
150 160 170 180 190 200
pF1KB6 RKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYD
: ..: :::....::. : ::: . ..:::: :.::.:......::.::::::....
NP_055 VKPFSENEARHFMHQIITGMLYLHSHGILHRDLTLSNLLLTRNMNIKIADFGLATQLKMP
110 120 130 140 150 160
210 220 230 240 250 260
pF1KB6 GERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIK
:.. :::::::::.::. ....:..: ::::.::..::::.:.:::.:. .:.: ..
NP_055 HEKHYTLCGTPNYISPEIATRSAHGLESDVWSLGCMFYTLLIGRPPFDTDTVKNTLNKVV
170 180 190 200 210 220
270 280 290 300 310 320
pF1KB6 KNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPR
.: .:. .. : .::...:. .:. : ... .:. :..
NP_055 LADYEMPSFLSIEAKDLIHQLLRRNPADRLSLSSVLDHPFMSRNSSTKSKDLGTVEDSID
230 240 250 260 270 280
330 340 350 360 370 380
pF1KB6 FSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSV
NP_055 SGHATISTAITASSSTSISGSLFDKRRLLIGQPLPNKMTVFPKNKSSTDFSSSGDGNSFY
290 300 310 320 330 340
>>XP_016863151 (OMIM: 605031,616171) PREDICTED: serine/t (971 aa)
initn: 683 init1: 529 opt: 687 Z-score: 321.5 bits: 70.2 E(85289): 3.6e-11
Smith-Waterman score: 687; 37.7% identity (76.2% similar) in 252 aa overlap (56-306:16-267)
30 40 50 60 70 80
pF1KB6 AAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVP
: .::::.:: .. . : : :..
XP_016 MPSTLDTCCIEDFKVGNLLGKGSFAGVYRAESIHTGLEVAIKMID
10 20 30 40
90 100 110 120 130 140
pF1KB6 KSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLE-LHKR
:. . : . .... :..:: .: : .. ....:::...:..:::.:. . . :..:
XP_016 KKAMYKAGMVQRVQNEVKIHCQLKHPSILELYNYFEDSNYVYLVLEMCHNGEMNRYLKNR
50 60 70 80 90 100
150 160 170 180 190 200
pF1KB6 RKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYD
: ..: :::....::. : ::: . ..:::: :.::.:......::.::::::....
XP_016 VKPFSENEARHFMHQIITGMLYLHSHGILHRDLTLSNLLLTRNMNIKIADFGLATQLKMP
110 120 130 140 150 160
210 220 230 240 250 260
pF1KB6 GERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIK
:.. :::::::::.::. ....:..: ::::.::..::::.:.:::.:. .:.: ..
XP_016 HEKHYTLCGTPNYISPEIATRSAHGLESDVWSLGCMFYTLLIGRPPFDTDTVKNTLNKVV
170 180 190 200 210 220
270 280 290 300 310 320
pF1KB6 KNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPR
.: .:. .. : .::...:. .:. : ... .:. :..
XP_016 LADYEMPSFLSIEAKDLIHQLLRRNPADRLSLSSVLDHPFMSRNSSTKSKDLGTVEDSID
230 240 250 260 270 280
330 340 350 360 370 380
pF1KB6 FSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSV
XP_016 SGHATISTAITASSSTSISGSLFDKRRLLIGQPLPNKMTVFPKNKSSTDFSSSGDGNSFY
290 300 310 320 330 340
>>NP_001177730 (OMIM: 605031,616171) serine/threonine-pr (929 aa)
initn: 618 init1: 529 opt: 639 Z-score: 301.3 bits: 66.4 E(85289): 4.8e-10
Smith-Waterman score: 639; 37.8% identity (78.7% similar) in 225 aa overlap (83-306:1-225)
60 70 80 90 100 110
pF1KB6 YVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQH
.. :. . : . .... :..:: .: :
NP_001 MIDKKAMYKAGMVQRVQNEVKIHCQLKHPS
10 20 30
120 130 140 150 160 170
pF1KB6 VVGFHGFFEDNDFVFVVLELCRRRSLLE-LHKRRKALTEPEARYYLRQIVLGCQYLHRNR
.. ....:::...:..:::.:. . . :..: : ..: :::....::. : ::: .
NP_001 ILELYNYFEDSNYVYLVLEMCHNGEMNRYLKNRVKPFSENEARHFMHQIITGMLYLHSHG
40 50 60 70 80 90
180 190 200 210 220 230
pF1KB6 VIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFE
..:::: :.::.:......::.::::::.... :.. :::::::::.::. ....:..:
NP_001 ILHRDLTLSNLLLTRNMNIKIADFGLATQLKMPHEKHYTLCGTPNYISPEIATRSAHGLE
100 110 120 130 140 150
240 250 260 270 280 290
pF1KB6 VDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPT
::::.::..::::.:.:::.:. .:.: .. .: .:. .. : .::...:. .:.
NP_001 SDVWSLGCMFYTLLIGRPPFDTDTVKNTLNKVVLADYEMPSFLSIEAKDLIHQLLRRNPA
160 170 180 190 200 210
300 310 320 330 340 350
pF1KB6 ARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPL
: ... .:. :..
NP_001 DRLSLSSVLDHPFMSRNSSTKSKDLGTVEDSIDSGHATISTAITASSSTSISGSLFDKRR
220 230 240 250 260 270
>>NP_001177728 (OMIM: 605031,616171) serine/threonine-pr (938 aa)
initn: 530 init1: 530 opt: 594 Z-score: 282.2 bits: 62.9 E(85289): 5.6e-09
Smith-Waterman score: 594; 40.0% identity (79.5% similar) in 205 aa overlap (103-306:31-234)
80 90 100 110 120 130
pF1KB6 ADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLEL
::: .: . . ....:::...:..:::.
NP_001 MATCIGEKIEDFKVGNLLGKGSFAGVYRAESIHTGL-EVAIKMLYNYFEDSNYVYLVLEM
10 20 30 40 50
140 150 160 170 180 190
pF1KB6 CRRRSLLE-LHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVK
:. . . :..: : ..: :::....::. : ::: . ..:::: :.::.:......:
NP_001 CHNGEMNRYLKNRVKPFSENEARHFMHQIITGMLYLHSHGILHRDLTLSNLLLTRNMNIK
60 70 80 90 100 110
200 210 220 230 240 250
pF1KB6 IGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPF
:.::::::.... :.. :::::::::.::. ....:..: ::::.::..::::.:.:::
NP_001 IADFGLATQLKMPHEKHYTLCGTPNYISPEIATRSAHGLESDVWSLGCMFYTLLIGRPPF
120 130 140 150 160 170
260 270 280 290 300 310
pF1KB6 ETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIP
.:. .:.: .. .: .:. .. : .::...:. .:. : ... .:. :..
NP_001 DTDTVKNTLNKVVLADYEMPSFLSIEAKDLIHQLLRRNPADRLSLSSVLDHPFMSRNSST
180 190 200 210 220 230
320 330 340 350 360 370
pF1KB6 ARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVD
NP_001 KSKDLGTVEDSIDSGHATISTAITASSSTSISGSLFDKRRLLIGQPLPNKMTVFPKNKSS
240 250 260 270 280 290
603 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sat Nov 5 13:39:39 2016 done: Sat Nov 5 13:39:40 2016
Total Scan time: 7.720 Total Display time: 0.080
Function used was FASTA [36.3.4 Apr, 2011]