FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE1346, 255 aa 1>>>pF1KE1346 255 - 255 aa - 255 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.9739+/-0.00032; mu= 16.5566+/- 0.020 mean_var=65.3071+/-13.306, 0's: 0 Z-trim(116.4): 298 B-trim: 0 in 0/55 Lambda= 0.158706 statistics sampled from 27196 (27512) to 27196 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.698), E-opt: 0.2 (0.323), width: 16 Scan time: 7.080 The best scores are: opt bits E(85289) NP_001902 (OMIM: 116830) cathepsin G preproprotein ( 255) 1737 406.1 3.2e-113 XP_011534801 (OMIM: 116830) PREDICTED: cathepsin G ( 269) 1626 380.7 1.5e-105 NP_004122 (OMIM: 123910) granzyme B isoform 1 prep ( 247) 999 237.1 2.3e-62 NP_219491 (OMIM: 116831) granzyme H isoform 1 prep ( 246) 982 233.2 3.4e-61 NP_001332940 (OMIM: 123910) granzyme B isoform 2 [ ( 235) 927 220.6 2e-57 NP_001827 (OMIM: 118938) chymase isoform 1 preprop ( 247) 855 204.1 1.9e-52 XP_011534985 (OMIM: 116831) PREDICTED: granzyme H ( 212) 817 195.4 7.2e-50 NP_001257709 (OMIM: 116831) granzyme H isoform 2 p ( 182) 555 135.3 7.3e-32 NP_002768 (OMIM: 177020) myeloblastin precursor [H ( 256) 550 134.3 2.1e-31 NP_001919 (OMIM: 134350,613912) complement factor ( 253) 518 127.0 3.3e-29 NP_002760 (OMIM: 167800,276000,614044) trypsin-1 p ( 247) 515 126.3 5.3e-29 NP_001304264 (OMIM: 134350,613912) complement fact ( 260) 513 125.8 7.5e-29 XP_011514713 (OMIM: 167800,276000,614044) PREDICTE ( 472) 515 126.5 8.8e-29 NP_071329 (OMIM: 606135) kallikrein-14 preproprote ( 267) 508 124.7 1.7e-28 NP_001298111 (OMIM: 606135) kallikrein-14 prepropr ( 267) 508 124.7 1.7e-28 NP_001257710 (OMIM: 116831) granzyme H isoform 3 p ( 160) 505 123.8 1.8e-28 NP_006135 (OMIM: 140050) granzyme A precursor [Hom ( 262) 499 122.6 7e-28 NP_056411 (OMIM: 605505) kallikrein-13 precursor [ ( 277) 497 122.2 1e-27 NP_005308 (OMIM: 600311) granzyme M isoform 1 prep ( 257) 496 121.9 1.1e-27 NP_002762 (OMIM: 613578) trypsin-3 isoform 2 prepr ( 247) 488 120.1 3.8e-27 NP_001184027 (OMIM: 613578) trypsin-3 isoform 4 pr ( 240) 479 118.0 1.6e-26 NP_001184026 (OMIM: 613578) trypsin-3 isoform 3 pr ( 261) 479 118.0 1.7e-26 XP_011526078 (OMIM: 130130,162800,202700) PREDICTE ( 267) 479 118.0 1.7e-26 XP_011526077 (OMIM: 130130,162800,202700) PREDICTE ( 267) 479 118.0 1.7e-26 NP_001963 (OMIM: 130130,162800,202700) neutrophil ( 267) 479 118.0 1.7e-26 NP_031369 (OMIM: 613578) trypsin-3 isoform 1 prepr ( 304) 479 118.1 1.9e-26 NP_009127 (OMIM: 605644) kallikrein-8 isoform 1 pr ( 260) 478 117.8 2e-26 NP_002761 (OMIM: 167800,601564) trypsin-2 isoform ( 247) 476 117.3 2.6e-26 NP_004908 (OMIM: 204700,603767) kallikrein-4 isofo ( 254) 475 117.1 3.1e-26 NP_653088 (OMIM: 605644) kallikrein-8 isoform 2 pr ( 305) 474 116.9 4.2e-26 XP_011516267 (OMIM: 613578) PREDICTED: trypsin-3 i ( 333) 474 117.0 4.5e-26 NP_001012982 (OMIM: 602652) kallikrein-6 isoform A ( 244) 472 116.4 4.8e-26 NP_002765 (OMIM: 602652) kallikrein-6 isoform A pr ( 244) 472 116.4 4.8e-26 NP_005037 (OMIM: 604438) kallikrein-7 isoform 1 pr ( 253) 467 115.3 1.1e-25 NP_644806 (OMIM: 604438) kallikrein-7 isoform 1 pr ( 253) 467 115.3 1.1e-25 NP_006844 (OMIM: 604434) kallikrein-11 isoform 1 p ( 250) 452 111.8 1.2e-24 NP_001129504 (OMIM: 604434) kallikrein-11 isoform ( 250) 452 111.8 1.2e-24 NP_659196 (OMIM: 604434) kallikrein-11 isoform 2 [ ( 282) 452 111.9 1.3e-24 NP_001691 (OMIM: 162815) azurocidin preproprotein ( 251) 441 109.3 6.7e-24 XP_011526438 (OMIM: 177020) PREDICTED: myeloblasti ( 206) 438 108.6 9.3e-24 NP_001295012 (OMIM: 118938) chymase isoform 2 [Hom ( 136) 430 106.6 2.4e-23 NP_002095 (OMIM: 600784) granzyme K precursor [Hom ( 264) 419 104.3 2.3e-22 NP_665901 (OMIM: 605539) kallikrein-12 isoform 2 p ( 248) 414 103.1 4.8e-22 NP_036447 (OMIM: 605504) kallikrein-9 precursor [H ( 250) 414 103.1 4.9e-22 NP_001898 (OMIM: 118888) chymotrypsin-like proteas ( 264) 413 102.9 6e-22 NP_001897 (OMIM: 118890) chymotrypsinogen B isofor ( 263) 410 102.2 9.6e-22 NP_001070959 (OMIM: 605643) kallikrein-5 prepropro ( 293) 405 101.1 2.3e-21 NP_036559 (OMIM: 605643) kallikrein-5 preproprotei ( 293) 405 101.1 2.3e-21 XP_011525005 (OMIM: 605643) PREDICTED: kallikrein- ( 293) 405 101.1 2.3e-21 XP_011525004 (OMIM: 605643) PREDICTED: kallikrein- ( 293) 405 101.1 2.3e-21 >>NP_001902 (OMIM: 116830) cathepsin G preproprotein [Ho (255 aa) initn: 1737 init1: 1737 opt: 1737 Z-score: 2153.6 bits: 406.1 E(85289): 3.2e-113 Smith-Waterman score: 1737; 100.0% identity (100.0% similar) in 255 aa overlap (1-255:1-255) 10 20 30 40 50 60 pF1KE1 MQPLLLLLAFLLPTGAEAGEIIGGRESRPHSRPYMAYLQIQSPAGQSRCGGFLVREDFVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MQPLLLLLAFLLPTGAEAGEIIGGRESRPHSRPYMAYLQIQSPAGQSRCGGFLVREDFVL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 TAAHCWGSNINVTLGAHNIQRRENTQQHITARRAIRHPQYNQRTIQNDIMLLQLSRRVRR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TAAHCWGSNINVTLGAHNIQRRENTQQHITARRAIRHPQYNQRTIQNDIMLLQLSRRVRR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 NRNVNPVALPRAQEGLRPGTLCTVAGWGRVSMRRGTDTLREVQLRVQRDRQCLRIFGSYD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NRNVNPVALPRAQEGLRPGTLCTVAGWGRVSMRRGTDTLREVQLRVQRDRQCLRIFGSYD 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 PRRQICVGDRRERKAAFKGDSGGPLLCNNVAHGIVSYGKSSGVPPEVFTRVSSFLPWIRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PRRQICVGDRRERKAAFKGDSGGPLLCNNVAHGIVSYGKSSGVPPEVFTRVSSFLPWIRT 190 200 210 220 230 240 250 pF1KE1 TMRSFKLLDQMETPL ::::::::::::::: NP_001 TMRSFKLLDQMETPL 250 >>XP_011534801 (OMIM: 116830) PREDICTED: cathepsin G iso (269 aa) initn: 1626 init1: 1626 opt: 1626 Z-score: 2016.0 bits: 380.7 E(85289): 1.5e-105 Smith-Waterman score: 1699; 94.8% identity (94.8% similar) in 269 aa overlap (1-255:1-269) 10 20 30 40 pF1KE1 MQPLLLLLAFLLPTGAEAG--------------EIIGGRESRPHSRPYMAYLQIQSPAGQ ::::::::::::::::::: ::::::::::::::::::::::::::: XP_011 MQPLLLLLAFLLPTGAEAGSASIELSAKCFLPGEIIGGRESRPHSRPYMAYLQIQSPAGQ 10 20 30 40 50 60 50 60 70 80 90 100 pF1KE1 SRCGGFLVREDFVLTAAHCWGSNINVTLGAHNIQRRENTQQHITARRAIRHPQYNQRTIQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SRCGGFLVREDFVLTAAHCWGSNINVTLGAHNIQRRENTQQHITARRAIRHPQYNQRTIQ 70 80 90 100 110 120 110 120 130 140 150 160 pF1KE1 NDIMLLQLSRRVRRNRNVNPVALPRAQEGLRPGTLCTVAGWGRVSMRRGTDTLREVQLRV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NDIMLLQLSRRVRRNRNVNPVALPRAQEGLRPGTLCTVAGWGRVSMRRGTDTLREVQLRV 130 140 150 160 170 180 170 180 190 200 210 220 pF1KE1 QRDRQCLRIFGSYDPRRQICVGDRRERKAAFKGDSGGPLLCNNVAHGIVSYGKSSGVPPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QRDRQCLRIFGSYDPRRQICVGDRRERKAAFKGDSGGPLLCNNVAHGIVSYGKSSGVPPE 190 200 210 220 230 240 230 240 250 pF1KE1 VFTRVSSFLPWIRTTMRSFKLLDQMETPL ::::::::::::::::::::::::::::: XP_011 VFTRVSSFLPWIRTTMRSFKLLDQMETPL 250 260 >>NP_004122 (OMIM: 123910) granzyme B isoform 1 prepropr (247 aa) initn: 1041 init1: 669 opt: 999 Z-score: 1240.6 bits: 237.1 E(85289): 2.3e-62 Smith-Waterman score: 999; 57.4% identity (82.7% similar) in 249 aa overlap (1-245:1-247) 10 20 30 40 50 60 pF1KE1 MQPLLLLLAFLLPTGAEAGEIIGGRESRPHSRPYMAYLQIQSPAGQSRCGGFLVREDFVL :::.:::::::: :.:::::::.:..::::::::::.: . . .::::::.:.:::: NP_004 MQPILLLLAFLLLPRADAGEIIGGHEAKPHSRPYMAYLMIWDQKSLKRCGGFLIRDDFVL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 TAAHCWGSNINVTLGAHNIQRRENTQQHITARRAIRHPQYNQRTIQNDIMLLQLSRRVRR ::::::::.::::::::::...: ::: : ..: : :: :: ....:::::::: :...: NP_004 TAAHCWGSSINVTLGAHNIKEQEPTQQFIPVKRPIPHPAYNPKNFSNDIMLLQLERKAKR 70 80 90 100 110 120 130 140 150 160 170 pF1KE1 NRNVNPVALPRAQEGLRPGTLCTVAGWGRVS-MRRGTDTLREVQLRVQRDRQC---LRIF .: :.:. :: . ..:: :.:::::... . . . ::.::.. ::.::.: :: . NP_004 TRAVQPLRLPSNKAQVKPGQTCSVAGWGQTAPLGKHSHTLQEVKMTVQEDRKCESDLRHY 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE1 GSYDPRRQICVGDRRERKAAFKGDSGGPLLCNNVAHGIVSYGKSSGVPPEVFTRVSSFLP :: ..:::: . .:..:::::::::.::.::.::::::...:.::.. :.::::. NP_004 --YDSTIELCVGDPEIKKTSFKGDSGGPLVCNKVAQGIVSYGRNNGMPPRACTKVSSFVH 190 200 210 220 230 240 250 pF1KE1 WIRTTMRSFKLLDQMETPL ::. ::. . NP_004 WIKKTMKRY 240 >>NP_219491 (OMIM: 116831) granzyme H isoform 1 prepropr (246 aa) initn: 967 init1: 707 opt: 982 Z-score: 1219.6 bits: 233.2 E(85289): 3.4e-61 Smith-Waterman score: 982; 57.8% identity (82.0% similar) in 244 aa overlap (1-243:1-244) 10 20 30 40 50 60 pF1KE1 MQPLLLLLAFLLPTGAEAGEIIGGRESRPHSRPYMAYLQIQSPAGQSRCGGFLVREDFVL :::.:::::::: :: . :::::.:..::::::::..:. . ...::::.:::.:::: NP_219 MQPFLLLLAFLLTPGAGTEEIIGGHEAKPHSRPYMAFVQFLQEKSRKRCGGILVRKDFVL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 TAAHCWGSNINVTLGAHNIQRRENTQQHITARRAIRHPQYNQRTIQNDIMLLQLSRRVRR ::::: ::.::::::::::...: ::: : ..: : :: :: ....:::::::: :... NP_219 TAAHCQGSSINVTLGAHNIKEQERTQQFIPVKRPIPHPAYNPKNFSNDIMLLQLERKAKW 70 80 90 100 110 120 130 140 150 160 170 pF1KE1 NRNVNPVALPRAQEGLRPGTLCTVAGWGRVSMRRGTDTLREVQLRVQRDRQCLRIF-GSY . : :. :: .. ..:: ::.::::: ::: . ::.:: : ::.: :: :.: :.: NP_219 TTAVRPLRLPSSKAQVKPGQLCSVAGWGYVSMSTLATTLQEVLLTVQKDCQCERLFHGNY 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE1 DPRRQICVGDRRERKAAFKGDSGGPLLCNNVAHGIVSYGKSSGVPPEVFTRVSSFLPWIR . .::::: .. ...:::::::::.:..::.::.:::...:.:: :. .:: :::::. NP_219 SRATEICVGDPKKTQTGFKGDSGGPLVCKDVAQGILSYGNKKGTPPGVYIKVSHFLPWIK 190 200 210 220 230 240 240 250 pF1KE1 TTMRSFKLLDQMETPL ::. NP_219 RTMKRL >>NP_001332940 (OMIM: 123910) granzyme B isoform 2 [Homo (235 aa) initn: 926 init1: 596 opt: 927 Z-score: 1151.8 bits: 220.6 E(85289): 2e-57 Smith-Waterman score: 927; 56.0% identity (82.8% similar) in 232 aa overlap (18-245:6-235) 10 20 30 40 50 60 pF1KE1 MQPLLLLLAFLLPTGAEAGEIIGGRESRPHSRPYMAYLQIQSPAGQSRCGGFLVREDFVL .::::::.:..::::::::::.: . . .::::::.:.:::: NP_001 MQTFPSGEIIGGHEAKPHSRPYMAYLMIWDQKSLKRCGGFLIRDDFVL 10 20 30 40 70 80 90 100 110 120 pF1KE1 TAAHCWGSNINVTLGAHNIQRRENTQQHITARRAIRHPQYNQRTIQNDIMLLQLSRRVRR ::::::::.::::::::::...: ::: : ..: : :: :: ....:::::::: :...: NP_001 TAAHCWGSSINVTLGAHNIKEQEPTQQFIPVKRPIPHPAYNPKNFSNDIMLLQLERKAKR 50 60 70 80 90 100 130 140 150 160 170 pF1KE1 NRNVNPVALPRAQEGLRPGTLCTVAGWGRVS-MRRGTDTLREVQLRVQRDRQC---LRIF .: :.:. :: . ..:: :.:::::... . . . ::.::.. ::.::.: :: . NP_001 TRAVQPLRLPSNKAQVKPGQTCSVAGWGQTAPLGKHSHTLQEVKMTVQEDRKCESDLRHY 110 120 130 140 150 160 180 190 200 210 220 230 pF1KE1 GSYDPRRQICVGDRRERKAAFKGDSGGPLLCNNVAHGIVSYGKSSGVPPEVFTRVSSFLP :: ..:::: . .:..:::::::::.::.::.::::::...:.::.. :.::::. NP_001 --YDSTIELCVGDPEIKKTSFKGDSGGPLVCNKVAQGIVSYGRNNGMPPRACTKVSSFVH 170 180 190 200 210 220 240 250 pF1KE1 WIRTTMRSFKLLDQMETPL ::. ::. . NP_001 WIKKTMKRY 230 >>NP_001827 (OMIM: 118938) chymase isoform 1 preproprote (247 aa) initn: 843 init1: 621 opt: 855 Z-score: 1062.4 bits: 204.1 E(85289): 1.9e-52 Smith-Waterman score: 855; 52.4% identity (77.6% similar) in 246 aa overlap (1-244:3-246) 10 20 30 40 50 pF1KE1 MQPLLLLLAFLLPTGAEAGEIIGGRESRPHSRPYMAYLQIQSPAGQSR-CGGFLVRED . :: ::: ::: . ::::::::: : .::::::::::.: . : :. :::::.:.. NP_001 MLLLPLPLLL-FLLCSRAEAGEIIGGTECKPHSRPYMAYLEIVTSNGPSKFCGGFLIRRN 10 20 30 40 50 60 70 80 90 100 110 pF1KE1 FVLTAAHCWGSNINVTLGAHNIQRRENTQQHITARRAIRHPQYNQRTIQNDIMLLQLSRR :::::::: : .:.:::::::: ..:.: :.. . . .:::.:: :...:::::.:... NP_001 FVLTAAHCAGRSITVTLGAHNITEEEDTWQKLEVIKQFRHPKYNTSTLHHDIMLLKLKEK 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE1 VRRNRNVNPVALPRAQEGLRPGTLCTVAGWGRVS-MRRGTDTLREVQLRVQRDRQCLRIF . . :. . .: . . :: .: ::::::.. .. :.:::.::.::.. . : . : NP_001 ASLTLAVGTLPFPSQFNFVPPGRMCRVAGWGRTGVLKPGSDTLQEVKLRLMDPQACSH-F 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE1 GSYDPRRQICVGDRRERKAAFKGDSGGPLLCNNVAHGIVSYGKSSGVPPEVFTRVSSFLP ..: :.:::. :. :.:::::::::::: .::.::::::.:.. :: ::::.: . : NP_001 RDFDHNLQLCVGNPRKTKSAFKGDSGGPLLCAGVAQGIVSYGRSDAKPPAVFTRISHYRP 180 190 200 210 220 230 240 250 pF1KE1 WIRTTMRSFKLLDQMETPL :: ... NP_001 WINQILQAN 240 >>XP_011534985 (OMIM: 116831) PREDICTED: granzyme H isof (212 aa) initn: 802 init1: 542 opt: 817 Z-score: 1016.3 bits: 195.4 E(85289): 7.2e-50 Smith-Waterman score: 817; 55.2% identity (81.0% similar) in 210 aa overlap (35-243:1-210) 10 20 30 40 50 60 pF1KE1 LLLLAFLLPTGAEAGEIIGGRESRPHSRPYMAYLQIQSPAGQSRCGGFLVREDFVLTAAH ::..:. . ...::::.:::.:::::::: XP_011 MAFVQFLQEKSRKRCGGILVRKDFVLTAAH 10 20 30 70 80 90 100 110 120 pF1KE1 CWGSNINVTLGAHNIQRRENTQQHITARRAIRHPQYNQRTIQNDIMLLQLSRRVRRNRNV : ::.::::::::::...: ::: : ..: : :: :: ....:::::::: :... . : XP_011 CQGSSINVTLGAHNIKEQERTQQFIPVKRPIPHPAYNPKNFSNDIMLLQLERKAKWTTAV 40 50 60 70 80 90 130 140 150 160 170 180 pF1KE1 NPVALPRAQEGLRPGTLCTVAGWGRVSMRRGTDTLREVQLRVQRDRQCLRIF-GSYDPRR :. :: .. ..:: ::.::::: ::: . ::.:: : ::.: :: :.: :.:. XP_011 RPLRLPSSKAQVKPGQLCSVAGWGYVSMSTLATTLQEVLLTVQKDCQCERLFHGNYSRAT 100 110 120 130 140 150 190 200 210 220 230 240 pF1KE1 QICVGDRRERKAAFKGDSGGPLLCNNVAHGIVSYGKSSGVPPEVFTRVSSFLPWIRTTMR .::::: .. ...:::::::::.:..::.::.:::...:.:: :. .:: :::::. ::. XP_011 EICVGDPKKTQTGFKGDSGGPLVCKDVAQGILSYGNKKGTPPGVYIKVSHFLPWIKRTMK 160 170 180 190 200 210 250 pF1KE1 SFKLLDQMETPL XP_011 RL >>NP_001257709 (OMIM: 116831) granzyme H isoform 2 precu (182 aa) initn: 747 init1: 542 opt: 555 Z-score: 693.1 bits: 135.3 E(85289): 7.3e-32 Smith-Waterman score: 626; 44.4% identity (63.0% similar) in 243 aa overlap (1-243:1-180) 10 20 30 40 50 60 pF1KE1 MQPLLLLLAFLLPTGAEAGEIIGGRESRPHSRPYMAYLQIQSPAGQSRCGGFLVREDFVL :::.:::::::: :: . :::::.:..::::::::..:. . ...::::.:::.:::: NP_001 MQPFLLLLAFLLTPGAGTEEIIGGHEAKPHSRPYMAFVQFLQEKSRKRCGGILVRKDFVL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 TAAHCWGSNINVTLGAHNIQRRENTQQHITARRAIRHPQYNQRTIQNDIMLLQLSRRVRR ::::: ::.::::::::::...: ::: : ..: : :: :: ....:::::::: :... NP_001 TAAHCQGSSINVTLGAHNIKEQERTQQFIPVKRPIPHPAYNPKNFSNDIMLLQLERKAKW 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 NRNVNPVALPRAQEGLRPGTLCTVAGWGRVSMRRGTDTLREVQLRVQRDRQCLRIFGSYD . : :. :: .. NP_001 TTAVRPLRLPSSKA---------------------------------------------- 130 190 200 210 220 230 240 pF1KE1 PRRQICVGDRRERKAAFKGDSGGPLLCNNVAHGIVSYGKSSGVPPEVFTRVSSFLPWIRT .:::::::.:..::.::.:::...:.:: :. .:: :::::. NP_001 -----------------QGDSGGPLVCKDVAQGILSYGNKKGTPPGVYIKVSHFLPWIKR 140 150 160 170 250 pF1KE1 TMRSFKLLDQMETPL ::. NP_001 TMKRL 180 >>NP_002768 (OMIM: 177020) myeloblastin precursor [Homo (256 aa) initn: 586 init1: 240 opt: 550 Z-score: 684.8 bits: 134.3 E(85289): 2.1e-31 Smith-Waterman score: 550; 39.0% identity (69.9% similar) in 246 aa overlap (6-243:13-248) 10 20 30 40 50 pF1KE1 MQPLLLLLAFLLPTGAEAGEIIGGRESRPHSRPYMAYLQIQSPAGQSRCGGFL .:::.:: .:.:.::.::.:..:::::::: ::... :. ::: : NP_002 MAHRPPSPALASVLLALLLSGAARAAEIVGGHEAQPHSRPYMASLQMRGNPGSHFCGGTL 10 20 30 40 50 60 60 70 80 90 100 pF1KE1 VREDFVLTAAHCWGSN----INVTLGAHNIQRRENTQQHITARRAIRHPQYNQRTIQNDI .. .:::::::: . .::.:::::.. .: ::::... ... . .:. .. ::. NP_002 IHPSFVLTAAHCLRDIPQRLVNVVLGAHNVRTQEPTQQHFSVAQVFLN-NYDAENKLNDV 70 80 90 100 110 110 120 130 140 150 160 pF1KE1 MLLQLSRRVRRNRNVNPVALPRAQEGLRPGTLCTVAGWGRVSMRRG-TDTLREVQLRVQR .:.::: . . .: : ::. .. . :: : . :::::. . ...:.:... : NP_002 LLIQLSSPANLSASVATVQLPQQDQPVPHGTQCLAMGWGRVGAHDPPAQVLQELNVTV-- 120 130 140 150 160 170 170 180 190 200 210 220 pF1KE1 DRQCLRIFGSYDPRRQICVGDRRERKAAFKGDSGGPLLCNNVAHGIVSY---GKSSGVPP . .: :. .::. :.. . :::::::.:... .:: :. : .. . : NP_002 ----VTFFCR--PH-NICTFVPRRKAGICFGDSGGPLICDGIIQGIDSFVIWGCATRLFP 180 190 200 210 220 230 230 240 250 pF1KE1 EVFTRVSSFLPWIRTTMRSFKLLDQMETPL . ::::. .. :::.:.: NP_002 DFFTRVALYVDWIRSTLRRVEAKGRP 240 250 >>NP_001919 (OMIM: 134350,613912) complement factor D is (253 aa) initn: 513 init1: 211 opt: 518 Z-score: 645.3 bits: 127.0 E(85289): 3.3e-29 Smith-Waterman score: 518; 38.1% identity (65.1% similar) in 252 aa overlap (8-242:7-252) 10 20 30 40 50 pF1KE1 MQPLLLLLAFLLPTGAEA------GEIIGGRESRPHSRPYMAYLQIQSPAGQSRCGGFLV :: :. :: : :.:.::::.. :.::::: .:.. : ::: :: NP_001 MHSWERLAVLVLLGAAACAAPPRGRILGGREAEAHARPYMASVQLN---GAHLCGGVLV 10 20 30 40 50 60 70 80 90 100 110 pF1KE1 REDFVLTAAHCW----GSNINVTLGAHNIQRRENTQQHITARRAIRHPQYNQRTIQNDIM :..::.:::: ....: ::::.... : ... . ::. ::. . ::..:.. NP_001 AEQWVLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLL 60 70 80 90 100 110 120 130 140 150 160 pF1KE1 LLQLSRRVRRNRNVNPVALPRAQEGLRPGTLCTVAGWGRVSMR-RGTDTLREVQLRVQRD :::::... . : :. :... . ::::: ::::: :. : :.:..: : : NP_001 LLQLSEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDR 120 130 140 150 160 170 170 180 190 200 210 220 pF1KE1 RQCLRIFGSYD---PRRQICVGDRRERKAAFKGDSGGPLLCNNVAHGIVSYGK---SSGV : : .: .: .:. . .:. . ::::::::.:..: .:.:. :. .. NP_001 ATCNR-RTHHDGAITERLMCA--ESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRK 180 190 200 210 220 230 230 240 250 pF1KE1 PPEVFTRVSSFLPWIRTTMRSFKLLDQMETPL : ..:::.:. :: ... NP_001 KPGIYTRVASYAAWIDSVLA 240 250 255 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Mon Nov 7 01:24:24 2016 done: Mon Nov 7 01:24:25 2016 Total Scan time: 7.080 Total Display time: 0.000 Function used was FASTA [36.3.4 Apr, 2011]