FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE1484, 655 aa 1>>>pF1KE1484 655 - 655 aa - 655 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 10.6062+/-0.000468; mu= -3.8205+/- 0.029 mean_var=390.4091+/-79.226, 0's: 0 Z-trim(120.7): 344 B-trim: 85 in 1/56 Lambda= 0.064910 statistics sampled from 35999 (36360) to 35999 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.73), E-opt: 0.2 (0.426), width: 16 Scan time: 13.670 The best scores are: opt bits E(85289) NP_006779 (OMIM: 605801) ralA-binding protein 1 [H ( 655) 4275 415.0 4.2e-115 NP_001243776 (OMIM: 600365) active breakpoint clus ( 310) 341 46.3 0.0002 NP_067585 (OMIM: 151410,608232,613065) breakpoint (1227) 351 47.8 0.00027 NP_004318 (OMIM: 151410,608232,613065) breakpoint (1271) 351 47.9 0.00028 NP_001269078 (OMIM: 600365) active breakpoint clus ( 641) 341 46.6 0.00033 NP_001309769 (OMIM: 600365) active breakpoint clus ( 813) 341 46.7 0.00039 NP_001153218 (OMIM: 600365) active breakpoint clus ( 813) 341 46.7 0.00039 NP_001083 (OMIM: 600365) active breakpoint cluster ( 822) 341 46.7 0.00039 NP_068781 (OMIM: 600365) active breakpoint cluster ( 859) 341 46.7 0.00041 XP_011509785 (OMIM: 610578) PREDICTED: rho GTPase- ( 397) 332 45.6 0.00043 XP_016859989 (OMIM: 610578) PREDICTED: rho GTPase- ( 432) 332 45.6 0.00045 XP_011509781 (OMIM: 610578) PREDICTED: rho GTPase- ( 475) 332 45.6 0.00049 XP_016859988 (OMIM: 610578) PREDICTED: rho GTPase- ( 475) 332 45.6 0.00049 NP_060930 (OMIM: 610578) rho GTPase-activating pro ( 475) 332 45.6 0.00049 NP_001309770 (OMIM: 600365) active breakpoint clus (1118) 341 46.9 0.00049 NP_112595 (OMIM: 610586) rho GTPase-activating pro ( 655) 325 45.1 0.00095 NP_859071 (OMIM: 614264) rho GTPase-activating pro ( 890) 327 45.5 0.001 XP_016872443 (OMIM: 610577) PREDICTED: rho GTPase- ( 742) 325 45.2 0.001 NP_001257627 (OMIM: 610577) rho GTPase-activating ( 769) 325 45.2 0.0011 XP_011518063 (OMIM: 610577) PREDICTED: rho GTPase- ( 772) 325 45.2 0.0011 NP_001257628 (OMIM: 610577) rho GTPase-activating ( 794) 325 45.2 0.0011 XP_005252701 (OMIM: 610577) PREDICTED: rho GTPase- ( 794) 325 45.2 0.0011 NP_001257626 (OMIM: 610577) rho GTPase-activating ( 799) 325 45.2 0.0011 XP_016856449 (OMIM: 614264) PREDICTED: rho GTPase- ( 967) 327 45.5 0.0011 NP_001257625 (OMIM: 610577) rho GTPase-activating ( 816) 325 45.2 0.0011 NP_001257624 (OMIM: 610577) rho GTPase-activating ( 841) 325 45.2 0.0011 NP_060757 (OMIM: 610577) rho GTPase-activating pro ( 846) 325 45.2 0.0011 XP_005245127 (OMIM: 614264) PREDICTED: rho GTPase- (1044) 327 45.5 0.0012 NP_001020769 (OMIM: 614264) rho GTPase-activating (1101) 327 45.5 0.0012 XP_011530602 (OMIM: 610586) PREDICTED: rho GTPase- ( 653) 321 44.7 0.0012 NP_001036134 (OMIM: 610586) rho GTPase-activating ( 653) 321 44.7 0.0012 NP_001274734 (OMIM: 610586) rho GTPase-activating ( 663) 321 44.8 0.0012 NP_001020787 (OMIM: 610586) rho GTPase-activating ( 748) 321 44.8 0.0014 XP_016882203 (OMIM: 605277) PREDICTED: rho GTPase- (1499) 325 45.5 0.0017 NP_004482 (OMIM: 605277) rho GTPase-activating pro (1499) 325 45.5 0.0017 XP_011519925 (OMIM: 604875) PREDICTED: unconventio (1737) 325 45.6 0.0019 XP_016877719 (OMIM: 604875) PREDICTED: unconventio (2547) 325 45.7 0.0024 XP_011519924 (OMIM: 604875) PREDICTED: unconventio (2566) 325 45.7 0.0024 XP_016877718 (OMIM: 604875) PREDICTED: unconventio (2566) 325 45.7 0.0024 XP_011519923 (OMIM: 604875) PREDICTED: unconventio (2598) 325 45.7 0.0025 XP_011519922 (OMIM: 604875) PREDICTED: unconventio (2618) 325 45.7 0.0025 XP_011519921 (OMIM: 604875) PREDICTED: unconventio (2619) 325 45.7 0.0025 XP_016877717 (OMIM: 604875) PREDICTED: unconventio (2619) 325 45.7 0.0025 XP_011519919 (OMIM: 604875) PREDICTED: unconventio (2637) 325 45.8 0.0025 XP_011519917 (OMIM: 604875) PREDICTED: unconventio (2638) 325 45.8 0.0025 XP_011519918 (OMIM: 604875) PREDICTED: unconventio (2638) 325 45.8 0.0025 XP_011519916 (OMIM: 604875) PREDICTED: unconventio (2638) 325 45.8 0.0025 XP_011519915 (OMIM: 604875) PREDICTED: unconventio (2638) 325 45.8 0.0025 NP_001280010 (OMIM: 602857) beta-chimaerin isoform ( 261) 300 42.4 0.0026 NP_001280002 (OMIM: 602857) beta-chimaerin isoform ( 287) 300 42.4 0.0027 >>NP_006779 (OMIM: 605801) ralA-binding protein 1 [Homo (655 aa) initn: 4275 init1: 4275 opt: 4275 Z-score: 2187.4 bits: 415.0 E(85289): 4.2e-115 Smith-Waterman score: 4275; 100.0% identity (100.0% similar) in 655 aa overlap (1-655:1-655) 10 20 30 40 50 60 pF1KE1 MTECFLPPTSSPSEHRRVEHGSGLTRTPSSEEISPTKFPGLYRTGEPSPPHDILHEPPDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 MTECFLPPTSSPSEHRRVEHGSGLTRTPSSEEISPTKFPGLYRTGEPSPPHDILHEPPDV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 VSDDEKDHGKKKGKFKKKEKRTEGYAAFQEDSSGDEAESPSKMKRSKGIHVFKKPSFSKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 VSDDEKDHGKKKGKFKKKEKRTEGYAAFQEDSSGDEAESPSKMKRSKGIHVFKKPSFSKK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 KEKDFKIKEKPKEEKHKEEKHKEEKHKEKKSKDLTAADVVKQWKEKKKKKKPIQEPEVPQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 KEKDFKIKEKPKEEKHKEEKHKEEKHKEKKSKDLTAADVVKQWKEKKKKKKPIQEPEVPQ 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 IDVPNLKPIFGIPLADAVERTMMYDGIRLPAVFRECIDYVEKYGMKCEGIYRVSGIKSKV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 IDVPNLKPIFGIPLADAVERTMMYDGIRLPAVFRECIDYVEKYGMKCEGIYRVSGIKSKV 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE1 DELKAAYDREESTNLEDYEPNTVASLLKQYLRDLPENLLTKELMPRFEEACGRTTETEKV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 DELKAAYDREESTNLEDYEPNTVASLLKQYLRDLPENLLTKELMPRFEEACGRTTETEKV 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE1 QEFQRLLKELPECNYLLISWLIVHMDHVIAKELETKMNIQNISIVLSPTVQISNRVLYVF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 QEFQRLLKELPECNYLLISWLIVHMDHVIAKELETKMNIQNISIVLSPTVQISNRVLYVF 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE1 FTHVQELFGNVVLKQVMKPLRWSNMATMPTLPETQAGIKEEIRRQEFLLNCLHRDLQGGI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 FTHVQELFGNVVLKQVMKPLRWSNMATMPTLPETQAGIKEEIRRQEFLLNCLHRDLQGGI 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE1 KDLSKEERLWEVQRILTALKRKLREAKRQECETKIAQEIASLSKEDVSKEEMNENEEVIN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 KDLSKEERLWEVQRILTALKRKLREAKRQECETKIAQEIASLSKEDVSKEEMNENEEVIN 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE1 ILLAQENEILTEQEELLAMEQFLRRQIASEKEEIERLRAEIAEIQSRQQHGRSETEEYSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 ILLAQENEILTEQEELLAMEQFLRRQIASEKEEIERLRAEIAEIQSRQQHGRSETEEYSS 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE1 ESESESEDEEELQIILEDLQRQNEELEIKNNHLNQAIHEEREAIIELRVQLRLLQMQRAK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 ESESESEDEEELQIILEDLQRQNEELEIKNNHLNQAIHEEREAIIELRVQLRLLQMQRAK 550 560 570 580 590 600 610 620 630 640 650 pF1KE1 AEQQAQEDEEPEWRGGAVQPPRDGVLEPKAAKEQPKAGKEPAKPSPSRDRKETSI ::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 AEQQAQEDEEPEWRGGAVQPPRDGVLEPKAAKEQPKAGKEPAKPSPSRDRKETSI 610 620 630 640 650 >>NP_001243776 (OMIM: 600365) active breakpoint cluster (310 aa) initn: 267 init1: 180 opt: 341 Z-score: 200.4 bits: 46.3 E(85289): 0.0002 Smith-Waterman score: 341; 31.2% identity (68.2% similar) in 192 aa overlap (189-376:95-282) 160 170 180 190 200 210 pF1KE1 VVKQWKEKKKKKKPIQEPEVPQIDVPNLKPIFGIPLADAVERTMMYDGIRLPAVFRECID .::. .. ...: . ..: . :.:.. NP_001 EMNGIKVEFSMKFTSRDMSLKRTPSKKQTGVFGVKISVVTKR----ERSKVPYIVRQCVE 70 80 90 100 110 120 220 230 240 250 260 270 pF1KE1 YVEKYGMKCEGIYRVSGIKSKVDELKAAYDREEST---NLEDYEPNTVASLLKQYLRDLP ::: :.. ::::.::. . .. :::..: ... : :.. :..:. :: :.:.:: NP_001 EVEKRGIEEVGIYRISGVATDIQALKAVFDANNKDILLMLSDMDINAIAGTLKLYFRELP 130 140 150 160 170 180 280 290 300 310 320 330 pF1KE1 ENLLTKELMPRFEEACGRTTETEKVQEFQRLLKELPECNYLLISWLIVHMDHVIAKELET : ::: .:.: : :. . . . : . ...::. ::. : . . .:. :. .: :: . NP_001 EPLLTDRLYPAFMEGIALSDPAAKENCMMHLLRSLPDPNLITFLFLLEHLKRVAEKEPIN 190 200 210 220 230 240 340 350 360 370 380 390 pF1KE1 KMNIQNISIVLSPTVQISNRVLY-VFFTHVQELFGNVVLKQVMKPLRWSNMATMPTLPET ::...:.. :..::. ..: . .: . ..... :. :: NP_001 KMSLHNLATVFGPTLLRPSEVESKAHLTSAADIWSHDVMAQVQVLLYYLQHPPISFAELK 250 260 270 280 290 300 400 410 420 430 440 450 pF1KE1 QAGIKEEIRRQEFLLNCLHRDLQGGIKDLSKEERLWEVQRILTALKRKLREAKRQECETK NP_001 RNTLYFSTDV 310 >>NP_067585 (OMIM: 151410,608232,613065) breakpoint clus (1227 aa) initn: 318 init1: 183 opt: 351 Z-score: 198.0 bits: 47.8 E(85289): 0.00027 Smith-Waterman score: 351; 34.5% identity (68.5% similar) in 165 aa overlap (189-350:1007-1167) 160 170 180 190 200 210 pF1KE1 VVKQWKEKKKKKKPIQEPEVPQIDVPNLKPIFGIPLADAVERTMMYDGIRLPAVFRECID .::. .: ...: . ..: . :.:.. NP_067 AMNGIEVKLSVKFNSREFSLKRMPSRKQTGVFGVKIAVVTKR----ERSKVPYIVRQCVE 980 990 1000 1010 1020 1030 220 230 240 250 260 270 pF1KE1 YVEKYGMKCEGIYRVSGIKSKVDELKAAYD---REESTNLEDYEPNTVASLLKQYLRDLP .:. ::. :::::::. . .. ::::.: .. :. . ... :..:. :: :.:.:: NP_067 EIERRGMEEVGIYRVSGVATDIQALKAAFDVNNKDVSVMMSEMDVNAIAGTLKLYFRELP 1040 1050 1060 1070 1080 1090 280 290 300 310 320 330 pF1KE1 ENLLTKELMPRFEEACGRTTETEKVQEFQRLLKELPECNYLLISWLIVHMDHVIAKELET : :.: :..: : :. . . . : . . :: ::: : : . .:. :. .: :: . NP_067 EPLFTDEFYPNFAEGIALSDPVAKESCMLNLLLSLPEANLLTFLFLLDHLKRVAEKEAVN 1100 1110 1120 1130 1140 1150 340 350 360 370 380 390 pF1KE1 KMNIQNISIVLSPTVQISNRVLYVFFTHVQELFGNVVLKQVMKPLRWSNMATMPTLPETQ ::...:.. :..::. NP_067 KMSLHNLATVFGPTLLRPSEKESKLPANPSQPITMTDSWSLEVMSQVQVLLYFLQLEAIP 1160 1170 1180 1190 1200 1210 >>NP_004318 (OMIM: 151410,608232,613065) breakpoint clus (1271 aa) initn: 318 init1: 183 opt: 351 Z-score: 197.9 bits: 47.9 E(85289): 0.00028 Smith-Waterman score: 351; 34.5% identity (68.5% similar) in 165 aa overlap (189-350:1051-1211) 160 170 180 190 200 210 pF1KE1 VVKQWKEKKKKKKPIQEPEVPQIDVPNLKPIFGIPLADAVERTMMYDGIRLPAVFRECID .::. .: ...: . ..: . :.:.. NP_004 AMNGIEVKLSVKFNSREFSLKRMPSRKQTGVFGVKIAVVTKR----ERSKVPYIVRQCVE 1030 1040 1050 1060 1070 220 230 240 250 260 270 pF1KE1 YVEKYGMKCEGIYRVSGIKSKVDELKAAYD---REESTNLEDYEPNTVASLLKQYLRDLP .:. ::. :::::::. . .. ::::.: .. :. . ... :..:. :: :.:.:: NP_004 EIERRGMEEVGIYRVSGVATDIQALKAAFDVNNKDVSVMMSEMDVNAIAGTLKLYFRELP 1080 1090 1100 1110 1120 1130 280 290 300 310 320 330 pF1KE1 ENLLTKELMPRFEEACGRTTETEKVQEFQRLLKELPECNYLLISWLIVHMDHVIAKELET : :.: :..: : :. . . . : . . :: ::: : : . .:. :. .: :: . NP_004 EPLFTDEFYPNFAEGIALSDPVAKESCMLNLLLSLPEANLLTFLFLLDHLKRVAEKEAVN 1140 1150 1160 1170 1180 1190 340 350 360 370 380 390 pF1KE1 KMNIQNISIVLSPTVQISNRVLYVFFTHVQELFGNVVLKQVMKPLRWSNMATMPTLPETQ ::...:.. :..::. NP_004 KMSLHNLATVFGPTLLRPSEKESKLPANPSQPITMTDSWSLEVMSQVQVLLYFLQLEAIP 1200 1210 1220 1230 1240 1250 >>NP_001269078 (OMIM: 600365) active breakpoint cluster (641 aa) initn: 267 init1: 180 opt: 341 Z-score: 196.5 bits: 46.6 E(85289): 0.00033 Smith-Waterman score: 341; 31.2% identity (68.2% similar) in 192 aa overlap (189-376:426-613) 160 170 180 190 200 210 pF1KE1 VVKQWKEKKKKKKPIQEPEVPQIDVPNLKPIFGIPLADAVERTMMYDGIRLPAVFRECID .::. .. ...: . ..: . :.:.. NP_001 EMNGIKVEFSMKFTSRDMSLKRTPSKKQTGVFGVKISVVTKR----ERSKVPYIVRQCVE 400 410 420 430 440 450 220 230 240 250 260 270 pF1KE1 YVEKYGMKCEGIYRVSGIKSKVDELKAAYDREEST---NLEDYEPNTVASLLKQYLRDLP ::: :.. ::::.::. . .. :::..: ... : :.. :..:. :: :.:.:: NP_001 EVEKRGIEEVGIYRISGVATDIQALKAVFDANNKDILLMLSDMDINAIAGTLKLYFRELP 460 470 480 490 500 510 280 290 300 310 320 330 pF1KE1 ENLLTKELMPRFEEACGRTTETEKVQEFQRLLKELPECNYLLISWLIVHMDHVIAKELET : ::: .:.: : :. . . . : . ...::. ::. : . . .:. :. .: :: . NP_001 EPLLTDRLYPAFMEGIALSDPAAKENCMMHLLRSLPDPNLITFLFLLEHLKRVAEKEPIN 520 530 540 550 560 570 340 350 360 370 380 390 pF1KE1 KMNIQNISIVLSPTVQISNRVLY-VFFTHVQELFGNVVLKQVMKPLRWSNMATMPTLPET ::...:.. :..::. ..: . .: . ..... :. :: NP_001 KMSLHNLATVFGPTLLRPSEVESKAHLTSAADIWSHDVMAQVQVLLYYLQHPPISFAELK 580 590 600 610 620 630 400 410 420 430 440 450 pF1KE1 QAGIKEEIRRQEFLLNCLHRDLQGGIKDLSKEERLWEVQRILTALKRKLREAKRQECETK NP_001 RNTLYFSTDV 640 >>NP_001309769 (OMIM: 600365) active breakpoint cluster (813 aa) initn: 267 init1: 180 opt: 341 Z-score: 195.2 bits: 46.7 E(85289): 0.00039 Smith-Waterman score: 341; 31.2% identity (68.2% similar) in 192 aa overlap (189-376:598-785) 160 170 180 190 200 210 pF1KE1 VVKQWKEKKKKKKPIQEPEVPQIDVPNLKPIFGIPLADAVERTMMYDGIRLPAVFRECID .::. .. ...: . ..: . :.:.. NP_001 EMNGIKVEFSMKFTSRDMSLKRTPSKKQTGVFGVKISVVTKR----ERSKVPYIVRQCVE 570 580 590 600 610 620 220 230 240 250 260 270 pF1KE1 YVEKYGMKCEGIYRVSGIKSKVDELKAAYDREEST---NLEDYEPNTVASLLKQYLRDLP ::: :.. ::::.::. . .. :::..: ... : :.. :..:. :: :.:.:: NP_001 EVEKRGIEEVGIYRISGVATDIQALKAVFDANNKDILLMLSDMDINAIAGTLKLYFRELP 630 640 650 660 670 680 280 290 300 310 320 330 pF1KE1 ENLLTKELMPRFEEACGRTTETEKVQEFQRLLKELPECNYLLISWLIVHMDHVIAKELET : ::: .:.: : :. . . . : . ...::. ::. : . . .:. :. .: :: . NP_001 EPLLTDRLYPAFMEGIALSDPAAKENCMMHLLRSLPDPNLITFLFLLEHLKRVAEKEPIN 690 700 710 720 730 740 340 350 360 370 380 390 pF1KE1 KMNIQNISIVLSPTVQISNRVLY-VFFTHVQELFGNVVLKQVMKPLRWSNMATMPTLPET ::...:.. :..::. ..: . .: . ..... :. :: NP_001 KMSLHNLATVFGPTLLRPSEVESKAHLTSAADIWSHDVMAQVQVLLYYLQHPPISFAELK 750 760 770 780 790 800 400 410 420 430 440 450 pF1KE1 QAGIKEEIRRQEFLLNCLHRDLQGGIKDLSKEERLWEVQRILTALKRKLREAKRQECETK NP_001 RNTLYFSTDV 810 >>NP_001153218 (OMIM: 600365) active breakpoint cluster (813 aa) initn: 267 init1: 180 opt: 341 Z-score: 195.2 bits: 46.7 E(85289): 0.00039 Smith-Waterman score: 341; 31.2% identity (68.2% similar) in 192 aa overlap (189-376:598-785) 160 170 180 190 200 210 pF1KE1 VVKQWKEKKKKKKPIQEPEVPQIDVPNLKPIFGIPLADAVERTMMYDGIRLPAVFRECID .::. .. ...: . ..: . :.:.. NP_001 EMNGIKVEFSMKFTSRDMSLKRTPSKKQTGVFGVKISVVTKR----ERSKVPYIVRQCVE 570 580 590 600 610 620 220 230 240 250 260 270 pF1KE1 YVEKYGMKCEGIYRVSGIKSKVDELKAAYDREEST---NLEDYEPNTVASLLKQYLRDLP ::: :.. ::::.::. . .. :::..: ... : :.. :..:. :: :.:.:: NP_001 EVEKRGIEEVGIYRISGVATDIQALKAVFDANNKDILLMLSDMDINAIAGTLKLYFRELP 630 640 650 660 670 680 280 290 300 310 320 330 pF1KE1 ENLLTKELMPRFEEACGRTTETEKVQEFQRLLKELPECNYLLISWLIVHMDHVIAKELET : ::: .:.: : :. . . . : . ...::. ::. : . . .:. :. .: :: . NP_001 EPLLTDRLYPAFMEGIALSDPAAKENCMMHLLRSLPDPNLITFLFLLEHLKRVAEKEPIN 690 700 710 720 730 740 340 350 360 370 380 390 pF1KE1 KMNIQNISIVLSPTVQISNRVLY-VFFTHVQELFGNVVLKQVMKPLRWSNMATMPTLPET ::...:.. :..::. ..: . .: . ..... :. :: NP_001 KMSLHNLATVFGPTLLRPSEVESKAHLTSAADIWSHDVMAQVQVLLYYLQHPPISFAELK 750 760 770 780 790 800 400 410 420 430 440 450 pF1KE1 QAGIKEEIRRQEFLLNCLHRDLQGGIKDLSKEERLWEVQRILTALKRKLREAKRQECETK NP_001 RNTLYFSTDV 810 >>NP_001083 (OMIM: 600365) active breakpoint cluster reg (822 aa) initn: 267 init1: 180 opt: 341 Z-score: 195.1 bits: 46.7 E(85289): 0.00039 Smith-Waterman score: 341; 31.2% identity (68.2% similar) in 192 aa overlap (189-376:607-794) 160 170 180 190 200 210 pF1KE1 VVKQWKEKKKKKKPIQEPEVPQIDVPNLKPIFGIPLADAVERTMMYDGIRLPAVFRECID .::. .. ...: . ..: . :.:.. NP_001 EMNGIKVEFSMKFTSRDMSLKRTPSKKQTGVFGVKISVVTKR----ERSKVPYIVRQCVE 580 590 600 610 620 630 220 230 240 250 260 270 pF1KE1 YVEKYGMKCEGIYRVSGIKSKVDELKAAYDREEST---NLEDYEPNTVASLLKQYLRDLP ::: :.. ::::.::. . .. :::..: ... : :.. :..:. :: :.:.:: NP_001 EVEKRGIEEVGIYRISGVATDIQALKAVFDANNKDILLMLSDMDINAIAGTLKLYFRELP 640 650 660 670 680 690 280 290 300 310 320 330 pF1KE1 ENLLTKELMPRFEEACGRTTETEKVQEFQRLLKELPECNYLLISWLIVHMDHVIAKELET : ::: .:.: : :. . . . : . ...::. ::. : . . .:. :. .: :: . NP_001 EPLLTDRLYPAFMEGIALSDPAAKENCMMHLLRSLPDPNLITFLFLLEHLKRVAEKEPIN 700 710 720 730 740 750 340 350 360 370 380 390 pF1KE1 KMNIQNISIVLSPTVQISNRVLY-VFFTHVQELFGNVVLKQVMKPLRWSNMATMPTLPET ::...:.. :..::. ..: . .: . ..... :. :: NP_001 KMSLHNLATVFGPTLLRPSEVESKAHLTSAADIWSHDVMAQVQVLLYYLQHPPISFAELK 760 770 780 790 800 810 400 410 420 430 440 450 pF1KE1 QAGIKEEIRRQEFLLNCLHRDLQGGIKDLSKEERLWEVQRILTALKRKLREAKRQECETK NP_001 RNTLYFSTDV 820 >>NP_068781 (OMIM: 600365) active breakpoint cluster reg (859 aa) initn: 267 init1: 180 opt: 341 Z-score: 194.9 bits: 46.7 E(85289): 0.00041 Smith-Waterman score: 341; 31.2% identity (68.2% similar) in 192 aa overlap (189-376:644-831) 160 170 180 190 200 210 pF1KE1 VVKQWKEKKKKKKPIQEPEVPQIDVPNLKPIFGIPLADAVERTMMYDGIRLPAVFRECID .::. .. ...: . ..: . :.:.. NP_068 EMNGIKVEFSMKFTSRDMSLKRTPSKKQTGVFGVKISVVTKR----ERSKVPYIVRQCVE 620 630 640 650 660 220 230 240 250 260 270 pF1KE1 YVEKYGMKCEGIYRVSGIKSKVDELKAAYDREEST---NLEDYEPNTVASLLKQYLRDLP ::: :.. ::::.::. . .. :::..: ... : :.. :..:. :: :.:.:: NP_068 EVEKRGIEEVGIYRISGVATDIQALKAVFDANNKDILLMLSDMDINAIAGTLKLYFRELP 670 680 690 700 710 720 280 290 300 310 320 330 pF1KE1 ENLLTKELMPRFEEACGRTTETEKVQEFQRLLKELPECNYLLISWLIVHMDHVIAKELET : ::: .:.: : :. . . . : . ...::. ::. : . . .:. :. .: :: . NP_068 EPLLTDRLYPAFMEGIALSDPAAKENCMMHLLRSLPDPNLITFLFLLEHLKRVAEKEPIN 730 740 750 760 770 780 340 350 360 370 380 390 pF1KE1 KMNIQNISIVLSPTVQISNRVLY-VFFTHVQELFGNVVLKQVMKPLRWSNMATMPTLPET ::...:.. :..::. ..: . .: . ..... :. :: NP_068 KMSLHNLATVFGPTLLRPSEVESKAHLTSAADIWSHDVMAQVQVLLYYLQHPPISFAELK 790 800 810 820 830 840 400 410 420 430 440 450 pF1KE1 QAGIKEEIRRQEFLLNCLHRDLQGGIKDLSKEERLWEVQRILTALKRKLREAKRQECETK NP_068 RNTLYFSTDV 850 >>XP_011509785 (OMIM: 610578) PREDICTED: rho GTPase-acti (397 aa) initn: 276 init1: 156 opt: 332 Z-score: 194.5 bits: 45.6 E(85289): 0.00043 Smith-Waterman score: 332; 28.8% identity (62.8% similar) in 250 aa overlap (113-350:115-360) 90 100 110 120 130 140 pF1KE1 EGYAAFQEDSSGDEAESPSKMKRSKGIHVFKKPSFSKKKEKDFKIKEKPKEE--KHKEEK : : ... . :::... . : .: . XP_011 SGNEFLLQSDIDFIILDWFHAIKNAIDRLPKDSSCPSRNLELFKIQRSSSTELLSHYDSD 90 100 110 120 130 140 150 160 170 180 190 pF1KE1 HKEEKHKEKKSKDL----TAADVVKQWKEKKKKKKPI-QEPEVPQIDVPNL--KPIFGIP ::.: ...:: . .:.:. . . :.. :: : ..: . .. .: ::: XP_011 IKEQKPEHRKSLMFRLHHSASDTSDKNRVKSRLKKFITRRPSLKTLQEKGLIKDQIFGSH 150 160 170 180 190 200 200 210 220 230 240 250 pF1KE1 LADAVERTMMYDGIRLPAVFRECIDYVEKYGMKCEGIYRVSGIKSKVDELKAAYDREEST : . :: .. .: ..::. ::: :. .::::::: . ...:. ..::. XP_011 LHKVCER----ENSTVPWFVKQCIEAVEKRGLDVDGIYRVSGNLATIQKLRFIVNQEEKL 210 220 230 240 250 260 260 270 280 290 300 310 pF1KE1 NLED--YEP-NTVASLLKQYLRDLPENLLTKELMPRFEEACGRTTETEKVQEFQRLLKEL ::.: .: ..:.. ::...:.::: :. .. .: :: . .. ... . :...: XP_011 NLDDSQWEDIHVVTGALKMFFRELPEPLFPYSFFEQFVEAIKKQDNNTRIEAVKSLVQKL 270 280 290 300 310 320 320 330 340 350 360 370 pF1KE1 PECNYLLISWLIVHMDHVIAKELETKMNIQNISIVLSPTVQISNRVLYVFFTHVQELFGN : : .. :. :. ...:: .. :. :...::..::. XP_011 PPPNRDTMKVLFGHLTKIVAKASKNLMSTQSLGIVFGPTLLRAENETGNMAIHMVYQNQI 330 340 350 360 370 380 380 390 400 410 420 430 pF1KE1 VVLKQVMKPLRWSNMATMPTLPETQAGIKEEIRRQEFLLNCLHRDLQGGIKDLSKEERLW XP_011 AELMLSEYSKIFGSEED 390 655 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Mon Nov 7 01:36:01 2016 done: Mon Nov 7 01:36:03 2016 Total Scan time: 13.670 Total Display time: 0.050 Function used was FASTA [36.3.4 Apr, 2011]