Result of FASTA (ccds) for
pFN21AB6239
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB6239, 751 aa
1>>>pF1KB6239 751 - 751 aa - 751 aa
Library: human.CCDS.faa
18511270 residues in 32554 sequences
Statistics: Expectation_n fit: rho(ln(x))= 7.0797+/-0.00098; mu= 14.1331+/- 0.060
mean_var=167.8428+/-32.084, 0's: 0 Z-trim(111.4): 40 B-trim: 34 in 1/50
Lambda= 0.098997
statistics sampled from 12341 (12378) to 12341 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.723), E-opt: 0.2 (0.38), width: 16
Scan time: 3.930
The best scores are: opt bits E(32554)
CCDS5891.1 EZH2 gene_id:2146|Hs108|chr7 ( 751) 5251 762.6 0
CCDS56516.1 EZH2 gene_id:2146|Hs108|chr7 ( 746) 5184 753.0 3.8e-217
CCDS56518.1 EZH2 gene_id:2146|Hs108|chr7 ( 737) 4643 675.7 6.9e-194
CCDS5892.1 EZH2 gene_id:2146|Hs108|chr7 ( 707) 4397 640.6 2.5e-183
CCDS56517.1 EZH2 gene_id:2146|Hs108|chr7 ( 695) 2931 431.2 2.7e-120
CCDS32659.1 EZH1 gene_id:2145|Hs108|chr17 ( 747) 2624 387.4 4.4e-107
CCDS82130.1 EZH1 gene_id:2145|Hs108|chr17 ( 738) 2414 357.4 4.7e-98
CCDS82129.1 EZH1 gene_id:2145|Hs108|chr17 ( 707) 2253 334.4 3.8e-91
>>CCDS5891.1 EZH2 gene_id:2146|Hs108|chr7 (751 aa)
initn: 5251 init1: 5251 opt: 5251 Z-score: 4063.6 bits: 762.6 E(32554): 0
Smith-Waterman score: 5251; 100.0% identity (100.0% similar) in 751 aa overlap (1-751:1-751)
10 20 30 40 50 60
pF1KB6 MGQTGKKSEKGPVCWRKRVKSEYMRLRQLKRFRRADEVKSMFSSNRQKILERTEILNQEW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS58 MGQTGKKSEKGPVCWRKRVKSEYMRLRQLKRFRRADEVKSMFSSNRQKILERTEILNQEW
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB6 KQRRIQPVHILTSVSSLRGTRECSVTSDLDFPTQVIPLKTLNAVASVPIMYSWSPLQQNF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS58 KQRRIQPVHILTSVSSLRGTRECSVTSDLDFPTQVIPLKTLNAVASVPIMYSWSPLQQNF
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB6 MVEDETVLHNIPYMGDEVLDQDGTFIEELIKNYDGKVHGDRECGFINDEIFVELVNALGQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS58 MVEDETVLHNIPYMGDEVLDQDGTFIEELIKNYDGKVHGDRECGFINDEIFVELVNALGQ
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB6 YNDDDDDDDGDDPEEREEKQKDLEDHRDDKESRPPRKFPSDKIFEAISSMFPDKGTAEEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS58 YNDDDDDDDGDDPEEREEKQKDLEDHRDDKESRPPRKFPSDKIFEAISSMFPDKGTAEEL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB6 KEKYKELTEQQLPGALPPECTPNIDGPNAKSVQREQSLHSFHTLFCRRCFKYDCFLHRKC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS58 KEKYKELTEQQLPGALPPECTPNIDGPNAKSVQREQSLHSFHTLFCRRCFKYDCFLHRKC
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB6 NYSFHATPNTYKRKNTETALDNKPCGPQCYQHLEGAKEFAAALTAERIKTPPKRPGGRRR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS58 NYSFHATPNTYKRKNTETALDNKPCGPQCYQHLEGAKEFAAALTAERIKTPPKRPGGRRR
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB6 GRLPNNSSRPSTPTINVLESKDTDSDREAGTETGGENNDKEEEEKKDETSSSSEANSRCQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS58 GRLPNNSSRPSTPTINVLESKDTDSDREAGTETGGENNDKEEEEKKDETSSSSEANSRCQ
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB6 TPIKMKPNIEPPENVEWSGAEASMFRVLIGTYYDNFCAIARLIGTKTCRQVYEFRVKESS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS58 TPIKMKPNIEPPENVEWSGAEASMFRVLIGTYYDNFCAIARLIGTKTCRQVYEFRVKESS
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB6 IIAPAPAEDVDTPPRKKKRKHRLWAAHCRKIQLKKDGSSNHVYNYQPCDHPRQPCDSSCP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS58 IIAPAPAEDVDTPPRKKKRKHRLWAAHCRKIQLKKDGSSNHVYNYQPCDHPRQPCDSSCP
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB6 CVIAQNFCEKFCQCSSECQNRFPGCRCKAQCNTKQCPCYLAVRECDPDLCLTCGAADHWD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS58 CVIAQNFCEKFCQCSSECQNRFPGCRCKAQCNTKQCPCYLAVRECDPDLCLTCGAADHWD
550 560 570 580 590 600
610 620 630 640 650 660
pF1KB6 SKNVSCKNCSIQRGSKKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS58 SKNVSCKNCSIQRGSKKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRG
610 620 630 640 650 660
670 680 690 700 710 720
pF1KB6 KVYDKYMCSFLFNLNNDFVVDATRKGNKIRFANHSVNPNCYAKVMMVNGDHRIGIFAKRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS58 KVYDKYMCSFLFNLNNDFVVDATRKGNKIRFANHSVNPNCYAKVMMVNGDHRIGIFAKRA
670 680 690 700 710 720
730 740 750
pF1KB6 IQTGEELFFDYRYSQADALKYVGIEREMEIP
:::::::::::::::::::::::::::::::
CCDS58 IQTGEELFFDYRYSQADALKYVGIEREMEIP
730 740 750
>>CCDS56516.1 EZH2 gene_id:2146|Hs108|chr7 (746 aa)
initn: 3178 init1: 3178 opt: 5184 Z-score: 4011.9 bits: 753.0 E(32554): 3.8e-217
Smith-Waterman score: 5184; 99.2% identity (99.2% similar) in 751 aa overlap (1-751:1-746)
10 20 30 40 50 60
pF1KB6 MGQTGKKSEKGPVCWRKRVKSEYMRLRQLKRFRRADEVKSMFSSNRQKILERTEILNQEW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS56 MGQTGKKSEKGPVCWRKRVKSEYMRLRQLKRFRRADEVKSMFSSNRQKILERTEILNQEW
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB6 KQRRIQPVHILTSVSSLRGTRECSVTSDLDFPTQVIPLKTLNAVASVPIMYSWSPLQQNF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS56 KQRRIQPVHILTSVSSLRGTRECSVTSDLDFPTQVIPLKTLNAVASVPIMYSWSPLQQNF
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB6 MVEDETVLHNIPYMGDEVLDQDGTFIEELIKNYDGKVHGDRECGFINDEIFVELVNALGQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS56 MVEDETVLHNIPYMGDEVLDQDGTFIEELIKNYDGKVHGDRECGFINDEIFVELVNALGQ
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB6 YNDDDDDDDGDDPEEREEKQKDLEDHRDDKESRPPRKFPSDKIFEAISSMFPDKGTAEEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS56 YNDDDDDDDGDDPEEREEKQKDLEDHRDDKESRPPRKFPSDKIFEAISSMFPDKGTAEEL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB6 KEKYKELTEQQLPGALPPECTPNIDGPNAKSVQREQSLHSFHTLFCRRCFKYDCFLHRKC
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS56 KEKYKELTEQQLPGALPPECTPNIDGPNAKSVQREQSLHSFHTLFCRRCFKYDCFLH---
250 260 270 280 290
310 320 330 340 350 360
pF1KB6 NYSFHATPNTYKRKNTETALDNKPCGPQCYQHLEGAKEFAAALTAERIKTPPKRPGGRRR
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS56 --PFHATPNTYKRKNTETALDNKPCGPQCYQHLEGAKEFAAALTAERIKTPPKRPGGRRR
300 310 320 330 340 350
370 380 390 400 410 420
pF1KB6 GRLPNNSSRPSTPTINVLESKDTDSDREAGTETGGENNDKEEEEKKDETSSSSEANSRCQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS56 GRLPNNSSRPSTPTINVLESKDTDSDREAGTETGGENNDKEEEEKKDETSSSSEANSRCQ
360 370 380 390 400 410
430 440 450 460 470 480
pF1KB6 TPIKMKPNIEPPENVEWSGAEASMFRVLIGTYYDNFCAIARLIGTKTCRQVYEFRVKESS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS56 TPIKMKPNIEPPENVEWSGAEASMFRVLIGTYYDNFCAIARLIGTKTCRQVYEFRVKESS
420 430 440 450 460 470
490 500 510 520 530 540
pF1KB6 IIAPAPAEDVDTPPRKKKRKHRLWAAHCRKIQLKKDGSSNHVYNYQPCDHPRQPCDSSCP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS56 IIAPAPAEDVDTPPRKKKRKHRLWAAHCRKIQLKKDGSSNHVYNYQPCDHPRQPCDSSCP
480 490 500 510 520 530
550 560 570 580 590 600
pF1KB6 CVIAQNFCEKFCQCSSECQNRFPGCRCKAQCNTKQCPCYLAVRECDPDLCLTCGAADHWD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS56 CVIAQNFCEKFCQCSSECQNRFPGCRCKAQCNTKQCPCYLAVRECDPDLCLTCGAADHWD
540 550 560 570 580 590
610 620 630 640 650 660
pF1KB6 SKNVSCKNCSIQRGSKKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS56 SKNVSCKNCSIQRGSKKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRG
600 610 620 630 640 650
670 680 690 700 710 720
pF1KB6 KVYDKYMCSFLFNLNNDFVVDATRKGNKIRFANHSVNPNCYAKVMMVNGDHRIGIFAKRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS56 KVYDKYMCSFLFNLNNDFVVDATRKGNKIRFANHSVNPNCYAKVMMVNGDHRIGIFAKRA
660 670 680 690 700 710
730 740 750
pF1KB6 IQTGEELFFDYRYSQADALKYVGIEREMEIP
:::::::::::::::::::::::::::::::
CCDS56 IQTGEELFFDYRYSQADALKYVGIEREMEIP
720 730 740
>>CCDS56518.1 EZH2 gene_id:2146|Hs108|chr7 (737 aa)
initn: 3912 init1: 3178 opt: 4643 Z-score: 3594.4 bits: 675.7 E(32554): 6.9e-194
Smith-Waterman score: 5103; 98.0% identity (98.0% similar) in 751 aa overlap (1-751:1-737)
10 20 30 40 50 60
pF1KB6 MGQTGKKSEKGPVCWRKRVKSEYMRLRQLKRFRRADEVKSMFSSNRQKILERTEILNQEW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS56 MGQTGKKSEKGPVCWRKRVKSEYMRLRQLKRFRRADEVKSMFSSNRQKILERTEILNQEW
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB6 KQRRIQPVHILTSVSSLRGTRECSVTSDLDFPTQVIPLKTLNAVASVPIMYSWSPLQQNF
::::::::::::: ::::::::::::::::::::::::::::::::::::::
CCDS56 KQRRIQPVHILTS---------CSVTSDLDFPTQVIPLKTLNAVASVPIMYSWSPLQQNF
70 80 90 100 110
130 140 150 160 170 180
pF1KB6 MVEDETVLHNIPYMGDEVLDQDGTFIEELIKNYDGKVHGDRECGFINDEIFVELVNALGQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS56 MVEDETVLHNIPYMGDEVLDQDGTFIEELIKNYDGKVHGDRECGFINDEIFVELVNALGQ
120 130 140 150 160 170
190 200 210 220 230 240
pF1KB6 YNDDDDDDDGDDPEEREEKQKDLEDHRDDKESRPPRKFPSDKIFEAISSMFPDKGTAEEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS56 YNDDDDDDDGDDPEEREEKQKDLEDHRDDKESRPPRKFPSDKIFEAISSMFPDKGTAEEL
180 190 200 210 220 230
250 260 270 280 290 300
pF1KB6 KEKYKELTEQQLPGALPPECTPNIDGPNAKSVQREQSLHSFHTLFCRRCFKYDCFLHRKC
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS56 KEKYKELTEQQLPGALPPECTPNIDGPNAKSVQREQSLHSFHTLFCRRCFKYDCFLH---
240 250 260 270 280
310 320 330 340 350 360
pF1KB6 NYSFHATPNTYKRKNTETALDNKPCGPQCYQHLEGAKEFAAALTAERIKTPPKRPGGRRR
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS56 --PFHATPNTYKRKNTETALDNKPCGPQCYQHLEGAKEFAAALTAERIKTPPKRPGGRRR
290 300 310 320 330 340
370 380 390 400 410 420
pF1KB6 GRLPNNSSRPSTPTINVLESKDTDSDREAGTETGGENNDKEEEEKKDETSSSSEANSRCQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS56 GRLPNNSSRPSTPTINVLESKDTDSDREAGTETGGENNDKEEEEKKDETSSSSEANSRCQ
350 360 370 380 390 400
430 440 450 460 470 480
pF1KB6 TPIKMKPNIEPPENVEWSGAEASMFRVLIGTYYDNFCAIARLIGTKTCRQVYEFRVKESS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS56 TPIKMKPNIEPPENVEWSGAEASMFRVLIGTYYDNFCAIARLIGTKTCRQVYEFRVKESS
410 420 430 440 450 460
490 500 510 520 530 540
pF1KB6 IIAPAPAEDVDTPPRKKKRKHRLWAAHCRKIQLKKDGSSNHVYNYQPCDHPRQPCDSSCP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS56 IIAPAPAEDVDTPPRKKKRKHRLWAAHCRKIQLKKDGSSNHVYNYQPCDHPRQPCDSSCP
470 480 490 500 510 520
550 560 570 580 590 600
pF1KB6 CVIAQNFCEKFCQCSSECQNRFPGCRCKAQCNTKQCPCYLAVRECDPDLCLTCGAADHWD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS56 CVIAQNFCEKFCQCSSECQNRFPGCRCKAQCNTKQCPCYLAVRECDPDLCLTCGAADHWD
530 540 550 560 570 580
610 620 630 640 650 660
pF1KB6 SKNVSCKNCSIQRGSKKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS56 SKNVSCKNCSIQRGSKKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRG
590 600 610 620 630 640
670 680 690 700 710 720
pF1KB6 KVYDKYMCSFLFNLNNDFVVDATRKGNKIRFANHSVNPNCYAKVMMVNGDHRIGIFAKRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS56 KVYDKYMCSFLFNLNNDFVVDATRKGNKIRFANHSVNPNCYAKVMMVNGDHRIGIFAKRA
650 660 670 680 690 700
730 740 750
pF1KB6 IQTGEELFFDYRYSQADALKYVGIEREMEIP
:::::::::::::::::::::::::::::::
CCDS56 IQTGEELFFDYRYSQADALKYVGIEREMEIP
710 720 730
>>CCDS5892.1 EZH2 gene_id:2146|Hs108|chr7 (707 aa)
initn: 3961 init1: 3178 opt: 4397 Z-score: 3404.7 bits: 640.6 E(32554): 2.5e-183
Smith-Waterman score: 4833; 94.0% identity (94.0% similar) in 751 aa overlap (1-751:1-707)
10 20 30 40 50 60
pF1KB6 MGQTGKKSEKGPVCWRKRVKSEYMRLRQLKRFRRADEVKSMFSSNRQKILERTEILNQEW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS58 MGQTGKKSEKGPVCWRKRVKSEYMRLRQLKRFRRADEVKSMFSSNRQKILERTEILNQEW
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB6 KQRRIQPVHILTSVSSLRGTRECSVTSDLDFPTQVIPLKTLNAVASVPIMYSWSPLQQNF
::::::::::::::::::::::
CCDS58 KQRRIQPVHILTSVSSLRGTRE--------------------------------------
70 80
130 140 150 160 170 180
pF1KB6 MVEDETVLHNIPYMGDEVLDQDGTFIEELIKNYDGKVHGDRECGFINDEIFVELVNALGQ
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS58 -VEDETVLHNIPYMGDEVLDQDGTFIEELIKNYDGKVHGDRECGFINDEIFVELVNALGQ
90 100 110 120 130 140
190 200 210 220 230 240
pF1KB6 YNDDDDDDDGDDPEEREEKQKDLEDHRDDKESRPPRKFPSDKIFEAISSMFPDKGTAEEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS58 YNDDDDDDDGDDPEEREEKQKDLEDHRDDKESRPPRKFPSDKIFEAISSMFPDKGTAEEL
150 160 170 180 190 200
250 260 270 280 290 300
pF1KB6 KEKYKELTEQQLPGALPPECTPNIDGPNAKSVQREQSLHSFHTLFCRRCFKYDCFLHRKC
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS58 KEKYKELTEQQLPGALPPECTPNIDGPNAKSVQREQSLHSFHTLFCRRCFKYDCFLH---
210 220 230 240 250
310 320 330 340 350 360
pF1KB6 NYSFHATPNTYKRKNTETALDNKPCGPQCYQHLEGAKEFAAALTAERIKTPPKRPGGRRR
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS58 --PFHATPNTYKRKNTETALDNKPCGPQCYQHLEGAKEFAAALTAERIKTPPKRPGGRRR
260 270 280 290 300 310
370 380 390 400 410 420
pF1KB6 GRLPNNSSRPSTPTINVLESKDTDSDREAGTETGGENNDKEEEEKKDETSSSSEANSRCQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS58 GRLPNNSSRPSTPTINVLESKDTDSDREAGTETGGENNDKEEEEKKDETSSSSEANSRCQ
320 330 340 350 360 370
430 440 450 460 470 480
pF1KB6 TPIKMKPNIEPPENVEWSGAEASMFRVLIGTYYDNFCAIARLIGTKTCRQVYEFRVKESS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS58 TPIKMKPNIEPPENVEWSGAEASMFRVLIGTYYDNFCAIARLIGTKTCRQVYEFRVKESS
380 390 400 410 420 430
490 500 510 520 530 540
pF1KB6 IIAPAPAEDVDTPPRKKKRKHRLWAAHCRKIQLKKDGSSNHVYNYQPCDHPRQPCDSSCP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS58 IIAPAPAEDVDTPPRKKKRKHRLWAAHCRKIQLKKDGSSNHVYNYQPCDHPRQPCDSSCP
440 450 460 470 480 490
550 560 570 580 590 600
pF1KB6 CVIAQNFCEKFCQCSSECQNRFPGCRCKAQCNTKQCPCYLAVRECDPDLCLTCGAADHWD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS58 CVIAQNFCEKFCQCSSECQNRFPGCRCKAQCNTKQCPCYLAVRECDPDLCLTCGAADHWD
500 510 520 530 540 550
610 620 630 640 650 660
pF1KB6 SKNVSCKNCSIQRGSKKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS58 SKNVSCKNCSIQRGSKKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRG
560 570 580 590 600 610
670 680 690 700 710 720
pF1KB6 KVYDKYMCSFLFNLNNDFVVDATRKGNKIRFANHSVNPNCYAKVMMVNGDHRIGIFAKRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS58 KVYDKYMCSFLFNLNNDFVVDATRKGNKIRFANHSVNPNCYAKVMMVNGDHRIGIFAKRA
620 630 640 650 660 670
730 740 750
pF1KB6 IQTGEELFFDYRYSQADALKYVGIEREMEIP
:::::::::::::::::::::::::::::::
CCDS58 IQTGEELFFDYRYSQADALKYVGIEREMEIP
680 690 700
>>CCDS56517.1 EZH2 gene_id:2146|Hs108|chr7 (695 aa)
initn: 3546 init1: 1498 opt: 2931 Z-score: 2273.2 bits: 431.2 E(32554): 2.7e-120
Smith-Waterman score: 4656; 92.3% identity (92.3% similar) in 751 aa overlap (1-751:1-695)
10 20 30 40 50 60
pF1KB6 MGQTGKKSEKGPVCWRKRVKSEYMRLRQLKRFRRADEVKSMFSSNRQKILERTEILNQEW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS56 MGQTGKKSEKGPVCWRKRVKSEYMRLRQLKRFRRADEVKSMFSSNRQKILERTEILNQEW
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB6 KQRRIQPVHILTSVSSLRGTRECSVTSDLDFPTQVIPLKTLNAVASVPIMYSWSPLQQNF
::::::::::::: ::::::::::::::::::::::::::::::::::::::
CCDS56 KQRRIQPVHILTS---------CSVTSDLDFPTQVIPLKTLNAVASVPIMYSWSPLQQNF
70 80 90 100 110
130 140 150 160 170 180
pF1KB6 MVEDETVLHNIPYMGDEVLDQDGTFIEELIKNYDGKVHGDRECGFINDEIFVELVNALGQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS56 MVEDETVLHNIPYMGDEVLDQDGTFIEELIKNYDGKVHGDRECGFINDEIFVELVNALGQ
120 130 140 150 160 170
190 200 210 220 230 240
pF1KB6 YNDDDDDDDGDDPEEREEKQKDLEDHRDDKESRPPRKFPSDKIFEAISSMFPDKGTAEEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS56 YNDDDDDDDGDDPEEREEKQKDLEDHRDDKESRPPRKFPSDKIFEAISSMFPDKGTAEEL
180 190 200 210 220 230
250 260 270 280 290 300
pF1KB6 KEKYKELTEQQLPGALPPECTPNIDGPNAKSVQREQSLHSFHTLFCRRCFKYDCFLHRKC
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS56 KEKYKELTEQQLPGALPPECTPNIDGPNAKSVQREQSLHSFHTLFCRRCFKYDCFLH---
240 250 260 270 280
310 320 330 340 350 360
pF1KB6 NYSFHATPNTYKRKNTETALDNKPCGPQCYQHLEGAKEFAAALTAERIKTPPKRPGGRRR
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS56 --PFHATPNTYKRKNTETALDNKPCGPQCYQHLEGAKEFAAALTAERIKTPPKRPGGRRR
290 300 310 320 330 340
370 380 390 400 410 420
pF1KB6 GRLPNNSSRPSTPTINVLESKDTDSDREAGTETGGENNDKEEEEKKDETSSSSEANSRCQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS56 GRLPNNSSRPSTPTINVLESKDTDSDREAGTETGGENNDKEEEEKKDETSSSSEANSRCQ
350 360 370 380 390 400
430 440 450 460 470 480
pF1KB6 TPIKMKPNIEPPENVEWSGAEASMFRVLIGTYYDNFCAIARLIGTKTCRQVYEFRVKESS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS56 TPIKMKPNIEPPENVEWSGAEASMFRVLIGTYYDNFCAIARLIGTKTCRQVYEFRVKESS
410 420 430 440 450 460
490 500 510 520 530 540
pF1KB6 IIAPAPAEDVDTPPRKKKRKHRLWAAHCRKIQLKKDGSSNHVYNYQPCDHPRQPCDSSCP
:::::::::::::::::::::::::::::::::::
CCDS56 IIAPAPAEDVDTPPRKKKRKHRLWAAHCRKIQLKKG------------------------
470 480 490 500
550 560 570 580 590 600
pF1KB6 CVIAQNFCEKFCQCSSECQNRFPGCRCKAQCNTKQCPCYLAVRECDPDLCLTCGAADHWD
::::::::::::::::::::::::::::::::::::::::::
CCDS56 ------------------QNRFPGCRCKAQCNTKQCPCYLAVRECDPDLCLTCGAADHWD
510 520 530 540
610 620 630 640 650 660
pF1KB6 SKNVSCKNCSIQRGSKKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS56 SKNVSCKNCSIQRGSKKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRG
550 560 570 580 590 600
670 680 690 700 710 720
pF1KB6 KVYDKYMCSFLFNLNNDFVVDATRKGNKIRFANHSVNPNCYAKVMMVNGDHRIGIFAKRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS56 KVYDKYMCSFLFNLNNDFVVDATRKGNKIRFANHSVNPNCYAKVMMVNGDHRIGIFAKRA
610 620 630 640 650 660
730 740 750
pF1KB6 IQTGEELFFDYRYSQADALKYVGIEREMEIP
:::::::::::::::::::::::::::::::
CCDS56 IQTGEELFFDYRYSQADALKYVGIEREMEIP
670 680 690
>>CCDS32659.1 EZH1 gene_id:2145|Hs108|chr17 (747 aa)
initn: 3162 init1: 1692 opt: 2624 Z-score: 2035.9 bits: 387.4 E(32554): 4.4e-107
Smith-Waterman score: 3322; 64.5% identity (81.7% similar) in 763 aa overlap (15-750:15-746)
10 20 30 40 50 60
pF1KB6 MGQTGKKSEKGPVCWRKRVKSEYMRLRQLKRFRRADEVKSMFSSNRQKILERTEILNQEW
:...:::::::::::::.. .:... .: :. :.:.:::.::
CCDS32 MEIPNPPTSKCITYWKRKVKSEYMRLRQLKRLQANMGAKALYVANFAKVQEKTQILNEEW
10 20 30 40 50 60
70 80 90 100 110
pF1KB6 KQRRIQPVHILTSVSSLRGTRECSVTSDLD-FPTQVIPLKTLNAVASVPIMYSWSPLQQN
:. :.:::. . ::. ..:.. : . : .: . ...::.:: :::::::::::::
CCDS32 KKLRVQPVQSMKPVSGHPFLKKCTIESIFPGFASQHMLMRSLNTVALVPIMYSWSPLQQN
70 80 90 100 110 120
120 130 140 150 160 170
pF1KB6 FMVEDETVLHNIPYMGDEVLDQDGTFIEELIKNYDGKVHGDREC--G--FINDEIFVELV
::::::::: ::::::::: ..: :::::::.::::::::..: : .:.: .:.:::
CCDS32 FMVEDETVLCNIPYMGDEVKEEDETFIEELINNYDGKVHGEEEMIPGSVLISDAVFLELV
130 140 150 160 170 180
180 190 200 210 220
pF1KB6 NALGQYNDDD-----DDDDG--DDPEE-----REEKQKDLEDHRDDKESRPPRKFPSDKI
.::.::.:.. : .:: :: .: :..:.. .: .. : :. ..::.: :
CCDS32 DALNQYSDEEEEGHNDTSDGKQDDSKEDLPVTRKRKRHAIEGNK--KSSK--KQFPNDMI
190 200 210 220 230
230 240 250 260 270 280
pF1KB6 FEAISSMFPDKGTAEELKEKYKELTEQQLPGALPPECTPNIDGPNAKSVQREQSLHSFHT
: ::.::::..:. ...::.:.::::.. :.::::.::::::::::::::::::::::::
CCDS32 FSAIASMFPENGVPDDMKERYRELTEMSDPNALPPQCTPNIDGPNAKSVQREQSLHSFHT
240 250 260 270 280 290
290 300 310 320 330 340
pF1KB6 LFCRRCFKYDCFLHRKCNYSFHATPNTYKRKNTETALDNKPCGPQCYQHLEGAKEFAAAL
:::::::::::::: ::::::.::::: : .. .::: .:. ::::::.:
CCDS32 LFCRRCFKYDCFLH-----PFHATPNVYKRKNKEIKIEPEPCGTDCFLLLEGAKEYAM--
300 310 320 330 340
350 360 370 380 390 400
pF1KB6 TAERIKTPPKRPGGRRRGRLPNNSSRPSTPTIN-VLESKDTDSDREAGTETGGENNDKEE
...: .. .:::: : :. :. . . : :.:. ::::..:
CCDS32 ----LHNPRSKCSGRRRRRHHIVSASCSNASASAVAETKEGDSDRDTG------------
350 360 370 380 390
410 420 430 440 450
pF1KB6 EEKKDETSSSSEANSRCQTPIKMKPNIEPP---------ENVEWSGAEASMFRVLIGTYY
.: .::::::::::::: :.: . :: : :::.::: :.:::. :::.
CCDS32 ---NDWASSSSEANSRCQTPTKQKASPAPPQLCVVEAPSEPVEWTGAEESLFRVFHGTYF
400 410 420 430 440 450
460 470 480 490 500 510
pF1KB6 DNFCAIARLIGTKTCRQVYEFRVKESSIIAPAPAEDVDTPPRKKKRKHRLWAAHCRKIQL
.:::.::::.:::::.::..: :::: .: :.... .: .::::::::::::::::::
CCDS32 NNFCSIARLLGTKTCKQVFQFAVKES-LILKLPTDELMNPSQKKKRKHRLWAAHCRKIQL
460 470 480 490 500
520 530 540 550 560 570
pF1KB6 KKDGSSNHVYNYQPCDHPRQPCDSSCPCVIAQNFCEKFCQCSSECQNRFPGCRCKAQCNT
:::.::..:::::::::: .::::.:::...::::::::::. .:::::::::::.::::
CCDS32 KKDNSSTQVYNYQPCDHPDRPCDSTCPCIMTQNFCEKFCQCNPDCQNRFPGCRCKTQCNT
510 520 530 540 550 560
580 590 600 610 620 630
pF1KB6 KQCPCYLAVRECDPDLCLTCGAADHWDSKNVSCKNCSIQRGSKKHLLLAPSDVAGWGIFI
::::::::::::::::::::::..::: : ::::::::::: ::::::::::::::: ::
CCDS32 KQCPCYLAVRECDPDLCLTCGASEHWDCKVVSCKNCSIQRGLKKHLLLAPSDVAGWGTFI
570 580 590 600 610 620
640 650 660 670 680 690
pF1KB6 KDPVQKNEFISEYCGEIISQDEADRRGKVYDKYMCSFLFNLNNDFVVDATRKGNKIRFAN
:. :::::::::::::.::::::::::::::::: :::::::::::::::::::::::::
CCDS32 KESVQKNEFISEYCGELISQDEADRRGKVYDKYMSSFLFNLNNDFVVDATRKGNKIRFAN
630 640 650 660 670 680
700 710 720 730 740 750
pF1KB6 HSVNPNCYAKVMMVNGDHRIGIFAKRAIQTGEELFFDYRYSQADALKYVGIEREMEIP
:::::::::::.:::::::::::::::::.:::::::::::::::::::::::: ..
CCDS32 HSVNPNCYAKVVMVNGDHRIGIFAKRAIQAGEELFFDYRYSQADALKYVGIERETDVL
690 700 710 720 730 740
>>CCDS82130.1 EZH1 gene_id:2145|Hs108|chr17 (738 aa)
initn: 3138 init1: 1692 opt: 2414 Z-score: 1873.9 bits: 357.4 E(32554): 4.7e-98
Smith-Waterman score: 3295; 64.2% identity (81.1% similar) in 763 aa overlap (15-750:15-737)
10 20 30 40 50 60
pF1KB6 MGQTGKKSEKGPVCWRKRVKSEYMRLRQLKRFRRADEVKSMFSSNRQKILERTEILNQEW
:...:::::::::::::.. .:... .: :. :.:.:::.::
CCDS82 MEIPNPPTSKCITYWKRKVKSEYMRLRQLKRLQANMGAKALYVANFAKVQEKTQILNEEW
10 20 30 40 50 60
70 80 90 100 110
pF1KB6 KQRRIQPVHILTSVSSLRGTRECSVTSDLD-FPTQVIPLKTLNAVASVPIMYSWSPLQQN
:. :.:::. . . :.. : . : .: . ...::.:: :::::::::::::
CCDS82 KKLRVQPVQSM---------KPCTIESIFPGFASQHMLMRSLNTVALVPIMYSWSPLQQN
70 80 90 100 110
120 130 140 150 160 170
pF1KB6 FMVEDETVLHNIPYMGDEVLDQDGTFIEELIKNYDGKVHGDREC--G--FINDEIFVELV
::::::::: ::::::::: ..: :::::::.::::::::..: : .:.: .:.:::
CCDS82 FMVEDETVLCNIPYMGDEVKEEDETFIEELINNYDGKVHGEEEMIPGSVLISDAVFLELV
120 130 140 150 160 170
180 190 200 210 220
pF1KB6 NALGQYNDDD-----DDDDG--DDPEE-----REEKQKDLEDHRDDKESRPPRKFPSDKI
.::.::.:.. : .:: :: .: :..:.. .: .. : :. ..::.: :
CCDS82 DALNQYSDEEEEGHNDTSDGKQDDSKEDLPVTRKRKRHAIEGNK--KSSK--KQFPNDMI
180 190 200 210 220
230 240 250 260 270 280
pF1KB6 FEAISSMFPDKGTAEELKEKYKELTEQQLPGALPPECTPNIDGPNAKSVQREQSLHSFHT
: ::.::::..:. ...::.:.::::.. :.::::.::::::::::::::::::::::::
CCDS82 FSAIASMFPENGVPDDMKERYRELTEMSDPNALPPQCTPNIDGPNAKSVQREQSLHSFHT
230 240 250 260 270 280
290 300 310 320 330 340
pF1KB6 LFCRRCFKYDCFLHRKCNYSFHATPNTYKRKNTETALDNKPCGPQCYQHLEGAKEFAAAL
:::::::::::::: ::::::.::::: : .. .::: .:. ::::::.:
CCDS82 LFCRRCFKYDCFLH-----PFHATPNVYKRKNKEIKIEPEPCGTDCFLLLEGAKEYAM--
290 300 310 320 330 340
350 360 370 380 390 400
pF1KB6 TAERIKTPPKRPGGRRRGRLPNNSSRPSTPTIN-VLESKDTDSDREAGTETGGENNDKEE
...: .. .:::: : :. :. . . : :.:. ::::..:
CCDS82 ----LHNPRSKCSGRRRRRHHIVSASCSNASASAVAETKEGDSDRDTG------------
350 360 370 380
410 420 430 440 450
pF1KB6 EEKKDETSSSSEANSRCQTPIKMKPNIEPP---------ENVEWSGAEASMFRVLIGTYY
.: .::::::::::::: :.: . :: : :::.::: :.:::. :::.
CCDS82 ---NDWASSSSEANSRCQTPTKQKASPAPPQLCVVEAPSEPVEWTGAEESLFRVFHGTYF
390 400 410 420 430 440
460 470 480 490 500 510
pF1KB6 DNFCAIARLIGTKTCRQVYEFRVKESSIIAPAPAEDVDTPPRKKKRKHRLWAAHCRKIQL
.:::.::::.:::::.::..: :::: .: :.... .: .::::::::::::::::::
CCDS82 NNFCSIARLLGTKTCKQVFQFAVKES-LILKLPTDELMNPSQKKKRKHRLWAAHCRKIQL
450 460 470 480 490 500
520 530 540 550 560 570
pF1KB6 KKDGSSNHVYNYQPCDHPRQPCDSSCPCVIAQNFCEKFCQCSSECQNRFPGCRCKAQCNT
:::.::..:::::::::: .::::.:::...::::::::::. .:::::::::::.::::
CCDS82 KKDNSSTQVYNYQPCDHPDRPCDSTCPCIMTQNFCEKFCQCNPDCQNRFPGCRCKTQCNT
510 520 530 540 550 560
580 590 600 610 620 630
pF1KB6 KQCPCYLAVRECDPDLCLTCGAADHWDSKNVSCKNCSIQRGSKKHLLLAPSDVAGWGIFI
::::::::::::::::::::::..::: : ::::::::::: ::::::::::::::: ::
CCDS82 KQCPCYLAVRECDPDLCLTCGASEHWDCKVVSCKNCSIQRGLKKHLLLAPSDVAGWGTFI
570 580 590 600 610 620
640 650 660 670 680 690
pF1KB6 KDPVQKNEFISEYCGEIISQDEADRRGKVYDKYMCSFLFNLNNDFVVDATRKGNKIRFAN
:. :::::::::::::.::::::::::::::::: :::::::::::::::::::::::::
CCDS82 KESVQKNEFISEYCGELISQDEADRRGKVYDKYMSSFLFNLNNDFVVDATRKGNKIRFAN
630 640 650 660 670 680
700 710 720 730 740 750
pF1KB6 HSVNPNCYAKVMMVNGDHRIGIFAKRAIQTGEELFFDYRYSQADALKYVGIEREMEIP
:::::::::::.:::::::::::::::::.:::::::::::::::::::::::: ..
CCDS82 HSVNPNCYAKVVMVNGDHRIGIFAKRAIQAGEELFFDYRYSQADALKYVGIERETDVL
690 700 710 720 730
>>CCDS82129.1 EZH1 gene_id:2145|Hs108|chr17 (707 aa)
initn: 3008 init1: 1692 opt: 2253 Z-score: 1749.8 bits: 334.4 E(32554): 3.8e-91
Smith-Waterman score: 3086; 61.5% identity (78.1% similar) in 762 aa overlap (15-750:15-706)
10 20 30 40 50 60
pF1KB6 MGQTGKKSEKGPVCWRKRVKSEYMRLRQLKRFRRADEVKSMFSSNRQKILERTEILNQEW
:...:::::::::::::.. .:... .: :. :.:.:::.::
CCDS82 MEIPNPPTSKCITYWKRKVKSEYMRLRQLKRLQANMGAKALYVANFAKVQEKTQILNEEW
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB6 KQRRIQPVHILTSVSSLRGTRECSVTSDLDFPTQVIPLKTLNAVASVPIMYSWSPLQQNF
:. :.::: .... :.. :.. .
CCDS82 KKLRVQPV------------------------------QSMKPVSGHPFLKK--------
70 80
130 140 150 160 170
pF1KB6 MVEDETVLHNIPYMGDEVLDQDGTFIEELIKNYDGKVHGDREC--G--FINDEIFVELVN
::::::: ::::::::: ..: :::::::.::::::::..: : .:.: .:.:::.
CCDS82 -VEDETVLCNIPYMGDEVKEEDETFIEELINNYDGKVHGEEEMIPGSVLISDAVFLELVD
90 100 110 120 130 140
180 190 200 210 220
pF1KB6 ALGQYNDDD-----DDDDG--DDPEE-----REEKQKDLEDHRDDKESRPPRKFPSDKIF
::.::.:.. : .:: :: .: :..:.. .: .. : :. ..::.: ::
CCDS82 ALNQYSDEEEEGHNDTSDGKQDDSKEDLPVTRKRKRHAIEGNK--KSSK--KQFPNDMIF
150 160 170 180 190
230 240 250 260 270 280
pF1KB6 EAISSMFPDKGTAEELKEKYKELTEQQLPGALPPECTPNIDGPNAKSVQREQSLHSFHTL
::.::::..:. ...::.:.::::.. :.::::.:::::::::::::::::::::::::
CCDS82 SAIASMFPENGVPDDMKERYRELTEMSDPNALPPQCTPNIDGPNAKSVQREQSLHSFHTL
200 210 220 230 240 250
290 300 310 320 330 340
pF1KB6 FCRRCFKYDCFLHRKCNYSFHATPNTYKRKNTETALDNKPCGPQCYQHLEGAKEFAAALT
::::::::::::: ::::::.::::: : .. .::: .:. ::::::.:
CCDS82 FCRRCFKYDCFLH-----PFHATPNVYKRKNKEIKIEPEPCGTDCFLLLEGAKEYAM---
260 270 280 290 300
350 360 370 380 390 400
pF1KB6 AERIKTPPKRPGGRRRGRLPNNSSRPSTPTIN-VLESKDTDSDREAGTETGGENNDKEEE
...: .. .:::: : :. :. . . : :.:. ::::..:
CCDS82 ---LHNPRSKCSGRRRRRHHIVSASCSNASASAVAETKEGDSDRDTG-------------
310 320 330 340 350
410 420 430 440 450
pF1KB6 EKKDETSSSSEANSRCQTPIKMKPNIEPP---------ENVEWSGAEASMFRVLIGTYYD
.: .::::::::::::: :.: . :: : :::.::: :.:::. :::..
CCDS82 --NDWASSSSEANSRCQTPTKQKASPAPPQLCVVEAPSEPVEWTGAEESLFRVFHGTYFN
360 370 380 390 400 410
460 470 480 490 500 510
pF1KB6 NFCAIARLIGTKTCRQVYEFRVKESSIIAPAPAEDVDTPPRKKKRKHRLWAAHCRKIQLK
:::.::::.:::::.::..: :::: .: :.... .: .:::::::::::::::::::
CCDS82 NFCSIARLLGTKTCKQVFQFAVKES-LILKLPTDELMNPSQKKKRKHRLWAAHCRKIQLK
420 430 440 450 460 470
520 530 540 550 560 570
pF1KB6 KDGSSNHVYNYQPCDHPRQPCDSSCPCVIAQNFCEKFCQCSSECQNRFPGCRCKAQCNTK
::.::..:::::::::: .::::.:::...::::::::::. .:::::::::::.:::::
CCDS82 KDNSSTQVYNYQPCDHPDRPCDSTCPCIMTQNFCEKFCQCNPDCQNRFPGCRCKTQCNTK
480 490 500 510 520 530
580 590 600 610 620 630
pF1KB6 QCPCYLAVRECDPDLCLTCGAADHWDSKNVSCKNCSIQRGSKKHLLLAPSDVAGWGIFIK
:::::::::::::::::::::..::: : ::::::::::: ::::::::::::::: :::
CCDS82 QCPCYLAVRECDPDLCLTCGASEHWDCKVVSCKNCSIQRGLKKHLLLAPSDVAGWGTFIK
540 550 560 570 580 590
640 650 660 670 680 690
pF1KB6 DPVQKNEFISEYCGEIISQDEADRRGKVYDKYMCSFLFNLNNDFVVDATRKGNKIRFANH
. :::::::::::::.::::::::::::::::: ::::::::::::::::::::::::::
CCDS82 ESVQKNEFISEYCGELISQDEADRRGKVYDKYMSSFLFNLNNDFVVDATRKGNKIRFANH
600 610 620 630 640 650
700 710 720 730 740 750
pF1KB6 SVNPNCYAKVMMVNGDHRIGIFAKRAIQTGEELFFDYRYSQADALKYVGIEREMEIP
::::::::::.:::::::::::::::::.:::::::::::::::::::::::: ..
CCDS82 SVNPNCYAKVVMVNGDHRIGIFAKRAIQAGEELFFDYRYSQADALKYVGIERETDVL
660 670 680 690 700
751 residues in 1 query sequences
18511270 residues in 32554 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Mon Nov 7 01:53:56 2016 done: Mon Nov 7 01:53:57 2016
Total Scan time: 3.930 Total Display time: 0.190
Function used was FASTA [36.3.4 Apr, 2011]