FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE4431, 450 aa 1>>>pF1KE4431 450 - 450 aa - 450 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 8.9637+/-0.00049; mu= 1.7546+/- 0.030 mean_var=265.7926+/-53.863, 0's: 0 Z-trim(116.3): 25 B-trim: 279 in 1/54 Lambda= 0.078669 statistics sampled from 27428 (27444) to 27428 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.678), E-opt: 0.2 (0.322), width: 16 Scan time: 9.370 The best scores are: opt bits E(85289) NP_001300927 (OMIM: 604378) beclin-1 isoform a [Ho ( 450) 2989 352.9 1e-96 NP_003757 (OMIM: 604378) beclin-1 isoform a [Homo ( 450) 2989 352.9 1e-96 NP_001300928 (OMIM: 604378) beclin-1 isoform b [Ho ( 355) 2267 270.9 3.9e-72 XP_016880753 (OMIM: 604378) PREDICTED: beclin-1 is ( 355) 2267 270.9 3.9e-72 XP_005257817 (OMIM: 604378) PREDICTED: beclin-1 is ( 355) 2267 270.9 3.9e-72 XP_011523723 (OMIM: 604378) PREDICTED: beclin-1 is ( 388) 2265 270.7 4.9e-72 XP_016880751 (OMIM: 604378) PREDICTED: beclin-1 is ( 388) 2265 270.7 4.9e-72 XP_016880752 (OMIM: 604378) PREDICTED: beclin-1 is ( 382) 2133 255.7 1.6e-67 XP_005257816 (OMIM: 604378) PREDICTED: beclin-1 is ( 382) 2133 255.7 1.6e-67 NP_001277622 (OMIM: 615687) beclin-2 [Homo sapiens ( 431) 1559 190.6 6.9e-48 NP_001300929 (OMIM: 604378) beclin-1 isoform c [Ho ( 279) 1201 149.8 8.7e-36 >>NP_001300927 (OMIM: 604378) beclin-1 isoform a [Homo s (450 aa) initn: 2989 init1: 2989 opt: 2989 Z-score: 1857.6 bits: 352.9 E(85289): 1e-96 Smith-Waterman score: 2989; 100.0% identity (100.0% similar) in 450 aa overlap (1-450:1-450) 10 20 30 40 50 60 pF1KE4 MEGSKTSNNSTMQVSFVCQRCSQPLKLDTSFKILDRVTIQELTAPLLTTAQAKPGETQEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MEGSKTSNNSTMQVSFVCQRCSQPLKLDTSFKILDRVTIQELTAPLLTTAQAKPGETQEE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 ETNSGEEPFIETPRQDGVSRRFIPPARMMSTESANSFTLIGEASDGGTMENLSRRLKVTG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ETNSGEEPFIETPRQDGVSRRFIPPARMMSTESANSFTLIGEASDGGTMENLSRRLKVTG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 DLFDIMSGQTDVDHPLCEECTDTLLDQLDTQLNVTENECQNYKRCLEILEQMNEDDSEQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DLFDIMSGQTDVDHPLCEECTDTLLDQLDTQLNVTENECQNYKRCLEILEQMNEDDSEQL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 QMELKELALEEERLIQELEDVEKNRKIVAENLEKVQAEAERLDQEEAQYQREYSEFKRQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QMELKELALEEERLIQELEDVEKNRKIVAENLEKVQAEAERLDQEEAQYQREYSEFKRQQ 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 LELDDELKSVENQMRYAQTQLDKLKKTNVFNATFHIWHSGQFGTINNFRLGRLPSVPVEW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LELDDELKSVENQMRYAQTQLDKLKKTNVFNATFHIWHSGQFGTINNFRLGRLPSVPVEW 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 NEINAAWGQTVLLLHALANKMGLKFQRYRLVPYGNHSYLESLTDKSKELPLYCSGGLRFF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NEINAAWGQTVLLLHALANKMGLKFQRYRLVPYGNHSYLESLTDKSKELPLYCSGGLRFF 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE4 WDNKFDHAMVAFLDCVQQFKEEVEKGETRFCLPYRMDVEKGKIEDTGGSGGSYSIKTQFN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 WDNKFDHAMVAFLDCVQQFKEEVEKGETRFCLPYRMDVEKGKIEDTGGSGGSYSIKTQFN 370 380 390 400 410 420 430 440 450 pF1KE4 SEEQWTKALKFMLTNLKWGLAWVSSQFYNK :::::::::::::::::::::::::::::: NP_001 SEEQWTKALKFMLTNLKWGLAWVSSQFYNK 430 440 450 >>NP_003757 (OMIM: 604378) beclin-1 isoform a [Homo sapi (450 aa) initn: 2989 init1: 2989 opt: 2989 Z-score: 1857.6 bits: 352.9 E(85289): 1e-96 Smith-Waterman score: 2989; 100.0% identity (100.0% similar) in 450 aa overlap (1-450:1-450) 10 20 30 40 50 60 pF1KE4 MEGSKTSNNSTMQVSFVCQRCSQPLKLDTSFKILDRVTIQELTAPLLTTAQAKPGETQEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 MEGSKTSNNSTMQVSFVCQRCSQPLKLDTSFKILDRVTIQELTAPLLTTAQAKPGETQEE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 ETNSGEEPFIETPRQDGVSRRFIPPARMMSTESANSFTLIGEASDGGTMENLSRRLKVTG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 ETNSGEEPFIETPRQDGVSRRFIPPARMMSTESANSFTLIGEASDGGTMENLSRRLKVTG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 DLFDIMSGQTDVDHPLCEECTDTLLDQLDTQLNVTENECQNYKRCLEILEQMNEDDSEQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 DLFDIMSGQTDVDHPLCEECTDTLLDQLDTQLNVTENECQNYKRCLEILEQMNEDDSEQL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 QMELKELALEEERLIQELEDVEKNRKIVAENLEKVQAEAERLDQEEAQYQREYSEFKRQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 QMELKELALEEERLIQELEDVEKNRKIVAENLEKVQAEAERLDQEEAQYQREYSEFKRQQ 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 LELDDELKSVENQMRYAQTQLDKLKKTNVFNATFHIWHSGQFGTINNFRLGRLPSVPVEW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 LELDDELKSVENQMRYAQTQLDKLKKTNVFNATFHIWHSGQFGTINNFRLGRLPSVPVEW 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 NEINAAWGQTVLLLHALANKMGLKFQRYRLVPYGNHSYLESLTDKSKELPLYCSGGLRFF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 NEINAAWGQTVLLLHALANKMGLKFQRYRLVPYGNHSYLESLTDKSKELPLYCSGGLRFF 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE4 WDNKFDHAMVAFLDCVQQFKEEVEKGETRFCLPYRMDVEKGKIEDTGGSGGSYSIKTQFN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 WDNKFDHAMVAFLDCVQQFKEEVEKGETRFCLPYRMDVEKGKIEDTGGSGGSYSIKTQFN 370 380 390 400 410 420 430 440 450 pF1KE4 SEEQWTKALKFMLTNLKWGLAWVSSQFYNK :::::::::::::::::::::::::::::: NP_003 SEEQWTKALKFMLTNLKWGLAWVSSQFYNK 430 440 450 >>NP_001300928 (OMIM: 604378) beclin-1 isoform b [Homo s (355 aa) initn: 2290 init1: 2267 opt: 2267 Z-score: 1416.0 bits: 270.9 E(85289): 3.9e-72 Smith-Waterman score: 2267; 99.7% identity (100.0% similar) in 348 aa overlap (1-348:1-348) 10 20 30 40 50 60 pF1KE4 MEGSKTSNNSTMQVSFVCQRCSQPLKLDTSFKILDRVTIQELTAPLLTTAQAKPGETQEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MEGSKTSNNSTMQVSFVCQRCSQPLKLDTSFKILDRVTIQELTAPLLTTAQAKPGETQEE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 ETNSGEEPFIETPRQDGVSRRFIPPARMMSTESANSFTLIGEASDGGTMENLSRRLKVTG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ETNSGEEPFIETPRQDGVSRRFIPPARMMSTESANSFTLIGEASDGGTMENLSRRLKVTG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 DLFDIMSGQTDVDHPLCEECTDTLLDQLDTQLNVTENECQNYKRCLEILEQMNEDDSEQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DLFDIMSGQTDVDHPLCEECTDTLLDQLDTQLNVTENECQNYKRCLEILEQMNEDDSEQL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 QMELKELALEEERLIQELEDVEKNRKIVAENLEKVQAEAERLDQEEAQYQREYSEFKRQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QMELKELALEEERLIQELEDVEKNRKIVAENLEKVQAEAERLDQEEAQYQREYSEFKRQQ 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 LELDDELKSVENQMRYAQTQLDKLKKTNVFNATFHIWHSGQFGTINNFRLGRLPSVPVEW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LELDDELKSVENQMRYAQTQLDKLKKTNVFNATFHIWHSGQFGTINNFRLGRLPSVPVEW 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 NEINAAWGQTVLLLHALANKMGLKFQRYRLVPYGNHSYLESLTDKSKELPLYCSGGLRFF :::::::::::::::::::::::::::::::::::::::::::::::. NP_001 NEINAAWGQTVLLLHALANKMGLKFQRYRLVPYGNHSYLESLTDKSKDGCGERQD 310 320 330 340 350 370 380 390 400 410 420 pF1KE4 WDNKFDHAMVAFLDCVQQFKEEVEKGETRFCLPYRMDVEKGKIEDTGGSGGSYSIKTQFN >>XP_016880753 (OMIM: 604378) PREDICTED: beclin-1 isofor (355 aa) initn: 2290 init1: 2267 opt: 2267 Z-score: 1416.0 bits: 270.9 E(85289): 3.9e-72 Smith-Waterman score: 2267; 99.7% identity (100.0% similar) in 348 aa overlap (1-348:1-348) 10 20 30 40 50 60 pF1KE4 MEGSKTSNNSTMQVSFVCQRCSQPLKLDTSFKILDRVTIQELTAPLLTTAQAKPGETQEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MEGSKTSNNSTMQVSFVCQRCSQPLKLDTSFKILDRVTIQELTAPLLTTAQAKPGETQEE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 ETNSGEEPFIETPRQDGVSRRFIPPARMMSTESANSFTLIGEASDGGTMENLSRRLKVTG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ETNSGEEPFIETPRQDGVSRRFIPPARMMSTESANSFTLIGEASDGGTMENLSRRLKVTG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 DLFDIMSGQTDVDHPLCEECTDTLLDQLDTQLNVTENECQNYKRCLEILEQMNEDDSEQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DLFDIMSGQTDVDHPLCEECTDTLLDQLDTQLNVTENECQNYKRCLEILEQMNEDDSEQL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 QMELKELALEEERLIQELEDVEKNRKIVAENLEKVQAEAERLDQEEAQYQREYSEFKRQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QMELKELALEEERLIQELEDVEKNRKIVAENLEKVQAEAERLDQEEAQYQREYSEFKRQQ 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 LELDDELKSVENQMRYAQTQLDKLKKTNVFNATFHIWHSGQFGTINNFRLGRLPSVPVEW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LELDDELKSVENQMRYAQTQLDKLKKTNVFNATFHIWHSGQFGTINNFRLGRLPSVPVEW 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 NEINAAWGQTVLLLHALANKMGLKFQRYRLVPYGNHSYLESLTDKSKELPLYCSGGLRFF :::::::::::::::::::::::::::::::::::::::::::::::. XP_016 NEINAAWGQTVLLLHALANKMGLKFQRYRLVPYGNHSYLESLTDKSKDGCGERQD 310 320 330 340 350 370 380 390 400 410 420 pF1KE4 WDNKFDHAMVAFLDCVQQFKEEVEKGETRFCLPYRMDVEKGKIEDTGGSGGSYSIKTQFN >>XP_005257817 (OMIM: 604378) PREDICTED: beclin-1 isofor (355 aa) initn: 2290 init1: 2267 opt: 2267 Z-score: 1416.0 bits: 270.9 E(85289): 3.9e-72 Smith-Waterman score: 2267; 99.7% identity (100.0% similar) in 348 aa overlap (1-348:1-348) 10 20 30 40 50 60 pF1KE4 MEGSKTSNNSTMQVSFVCQRCSQPLKLDTSFKILDRVTIQELTAPLLTTAQAKPGETQEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MEGSKTSNNSTMQVSFVCQRCSQPLKLDTSFKILDRVTIQELTAPLLTTAQAKPGETQEE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 ETNSGEEPFIETPRQDGVSRRFIPPARMMSTESANSFTLIGEASDGGTMENLSRRLKVTG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ETNSGEEPFIETPRQDGVSRRFIPPARMMSTESANSFTLIGEASDGGTMENLSRRLKVTG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 DLFDIMSGQTDVDHPLCEECTDTLLDQLDTQLNVTENECQNYKRCLEILEQMNEDDSEQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DLFDIMSGQTDVDHPLCEECTDTLLDQLDTQLNVTENECQNYKRCLEILEQMNEDDSEQL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 QMELKELALEEERLIQELEDVEKNRKIVAENLEKVQAEAERLDQEEAQYQREYSEFKRQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QMELKELALEEERLIQELEDVEKNRKIVAENLEKVQAEAERLDQEEAQYQREYSEFKRQQ 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 LELDDELKSVENQMRYAQTQLDKLKKTNVFNATFHIWHSGQFGTINNFRLGRLPSVPVEW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LELDDELKSVENQMRYAQTQLDKLKKTNVFNATFHIWHSGQFGTINNFRLGRLPSVPVEW 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 NEINAAWGQTVLLLHALANKMGLKFQRYRLVPYGNHSYLESLTDKSKELPLYCSGGLRFF :::::::::::::::::::::::::::::::::::::::::::::::. XP_005 NEINAAWGQTVLLLHALANKMGLKFQRYRLVPYGNHSYLESLTDKSKDGCGERQD 310 320 330 340 350 370 380 390 400 410 420 pF1KE4 WDNKFDHAMVAFLDCVQQFKEEVEKGETRFCLPYRMDVEKGKIEDTGGSGGSYSIKTQFN >>XP_011523723 (OMIM: 604378) PREDICTED: beclin-1 isofor (388 aa) initn: 2265 init1: 2265 opt: 2265 Z-score: 1414.3 bits: 270.7 E(85289): 4.9e-72 Smith-Waterman score: 2265; 100.0% identity (100.0% similar) in 347 aa overlap (1-347:1-347) 10 20 30 40 50 60 pF1KE4 MEGSKTSNNSTMQVSFVCQRCSQPLKLDTSFKILDRVTIQELTAPLLTTAQAKPGETQEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MEGSKTSNNSTMQVSFVCQRCSQPLKLDTSFKILDRVTIQELTAPLLTTAQAKPGETQEE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 ETNSGEEPFIETPRQDGVSRRFIPPARMMSTESANSFTLIGEASDGGTMENLSRRLKVTG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ETNSGEEPFIETPRQDGVSRRFIPPARMMSTESANSFTLIGEASDGGTMENLSRRLKVTG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 DLFDIMSGQTDVDHPLCEECTDTLLDQLDTQLNVTENECQNYKRCLEILEQMNEDDSEQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DLFDIMSGQTDVDHPLCEECTDTLLDQLDTQLNVTENECQNYKRCLEILEQMNEDDSEQL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 QMELKELALEEERLIQELEDVEKNRKIVAENLEKVQAEAERLDQEEAQYQREYSEFKRQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QMELKELALEEERLIQELEDVEKNRKIVAENLEKVQAEAERLDQEEAQYQREYSEFKRQQ 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 LELDDELKSVENQMRYAQTQLDKLKKTNVFNATFHIWHSGQFGTINNFRLGRLPSVPVEW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LELDDELKSVENQMRYAQTQLDKLKKTNVFNATFHIWHSGQFGTINNFRLGRLPSVPVEW 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 NEINAAWGQTVLLLHALANKMGLKFQRYRLVPYGNHSYLESLTDKSKELPLYCSGGLRFF ::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NEINAAWGQTVLLLHALANKMGLKFQRYRLVPYGNHSYLESLTDKSKAEVQWHDLGLLQP 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE4 WDNKFDHAMVAFLDCVQQFKEEVEKGETRFCLPYRMDVEKGKIEDTGGSGGSYSIKTQFN XP_011 PPPGFKQFPCLSLLSIWDYRHAPPRPAN 370 380 >>XP_016880751 (OMIM: 604378) PREDICTED: beclin-1 isofor (388 aa) initn: 2265 init1: 2265 opt: 2265 Z-score: 1414.3 bits: 270.7 E(85289): 4.9e-72 Smith-Waterman score: 2265; 100.0% identity (100.0% similar) in 347 aa overlap (1-347:1-347) 10 20 30 40 50 60 pF1KE4 MEGSKTSNNSTMQVSFVCQRCSQPLKLDTSFKILDRVTIQELTAPLLTTAQAKPGETQEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MEGSKTSNNSTMQVSFVCQRCSQPLKLDTSFKILDRVTIQELTAPLLTTAQAKPGETQEE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 ETNSGEEPFIETPRQDGVSRRFIPPARMMSTESANSFTLIGEASDGGTMENLSRRLKVTG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ETNSGEEPFIETPRQDGVSRRFIPPARMMSTESANSFTLIGEASDGGTMENLSRRLKVTG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 DLFDIMSGQTDVDHPLCEECTDTLLDQLDTQLNVTENECQNYKRCLEILEQMNEDDSEQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DLFDIMSGQTDVDHPLCEECTDTLLDQLDTQLNVTENECQNYKRCLEILEQMNEDDSEQL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 QMELKELALEEERLIQELEDVEKNRKIVAENLEKVQAEAERLDQEEAQYQREYSEFKRQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QMELKELALEEERLIQELEDVEKNRKIVAENLEKVQAEAERLDQEEAQYQREYSEFKRQQ 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 LELDDELKSVENQMRYAQTQLDKLKKTNVFNATFHIWHSGQFGTINNFRLGRLPSVPVEW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LELDDELKSVENQMRYAQTQLDKLKKTNVFNATFHIWHSGQFGTINNFRLGRLPSVPVEW 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 NEINAAWGQTVLLLHALANKMGLKFQRYRLVPYGNHSYLESLTDKSKELPLYCSGGLRFF ::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NEINAAWGQTVLLLHALANKMGLKFQRYRLVPYGNHSYLESLTDKSKAEVQWHDLGLLQP 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE4 WDNKFDHAMVAFLDCVQQFKEEVEKGETRFCLPYRMDVEKGKIEDTGGSGGSYSIKTQFN XP_016 PPPGFKQFPCLSLLSIWDYRHAPPRPAN 370 380 >>XP_016880752 (OMIM: 604378) PREDICTED: beclin-1 isofor (382 aa) initn: 2133 init1: 2133 opt: 2133 Z-score: 1333.4 bits: 255.7 E(85289): 1.6e-67 Smith-Waterman score: 2358; 84.9% identity (84.9% similar) in 450 aa overlap (1-450:1-382) 10 20 30 40 50 60 pF1KE4 MEGSKTSNNSTMQVSFVCQRCSQPLKLDTSFKILDRVTIQELTAPLLTTAQAKPGETQEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MEGSKTSNNSTMQVSFVCQRCSQPLKLDTSFKILDRVTIQELTAPLLTTAQAKPGETQEE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 ETNSGEEPFIETPRQDGVSRRFIPPARMMSTESANSFTLIGEASDGGTMENLSRRLKVTG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ETNSGEEPFIETPRQDGVSRRFIPPARMMSTESANSFTLIGEASDGGTMENLSRRLKVTG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 DLFDIMSGQTDVDHPLCEECTDTLLDQLDTQLNVTENECQNYKRCLEILEQMNEDDSEQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DLFDIMSGQTDVDHPLCEECTDTLLDQLDTQLNVTENECQNYKRCLEILEQMNEDDSEQL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 QMELKELALEEERLIQELEDVEKNRKIVAENLEKVQAEAERLDQEEAQYQREYSEFKRQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QMELKELALEEERLIQELEDVEKNRKIVAENLEKVQAEAERLDQEEAQYQREYSEFKRQQ 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 LELDDELKSVENQMRYAQTQLDKLKKTNVFNATFHIWHSGQFGTINNFRLGRLPSVPVEW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LELDDELKSVENQMRYAQTQLDKLKKTNVFNATFHIWHSGQFGTINNFRLGRLPSVPVEW 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 NEINAAWGQTVLLLHALANKMGLKFQRYRLVPYGNHSYLESLTDKSKELPLYCSGGLRFF ::::::::::::::::::::::::::: XP_016 NEINAAWGQTVLLLHALANKMGLKFQR--------------------------------- 310 320 370 380 390 400 410 420 pF1KE4 WDNKFDHAMVAFLDCVQQFKEEVEKGETRFCLPYRMDVEKGKIEDTGGSGGSYSIKTQFN ::::::::::::::::::::::::: XP_016 -----------------------------------MDVEKGKIEDTGGSGGSYSIKTQFN 330 340 350 430 440 450 pF1KE4 SEEQWTKALKFMLTNLKWGLAWVSSQFYNK :::::::::::::::::::::::::::::: XP_016 SEEQWTKALKFMLTNLKWGLAWVSSQFYNK 360 370 380 >>XP_005257816 (OMIM: 604378) PREDICTED: beclin-1 isofor (382 aa) initn: 2133 init1: 2133 opt: 2133 Z-score: 1333.4 bits: 255.7 E(85289): 1.6e-67 Smith-Waterman score: 2358; 84.9% identity (84.9% similar) in 450 aa overlap (1-450:1-382) 10 20 30 40 50 60 pF1KE4 MEGSKTSNNSTMQVSFVCQRCSQPLKLDTSFKILDRVTIQELTAPLLTTAQAKPGETQEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MEGSKTSNNSTMQVSFVCQRCSQPLKLDTSFKILDRVTIQELTAPLLTTAQAKPGETQEE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 ETNSGEEPFIETPRQDGVSRRFIPPARMMSTESANSFTLIGEASDGGTMENLSRRLKVTG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ETNSGEEPFIETPRQDGVSRRFIPPARMMSTESANSFTLIGEASDGGTMENLSRRLKVTG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 DLFDIMSGQTDVDHPLCEECTDTLLDQLDTQLNVTENECQNYKRCLEILEQMNEDDSEQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DLFDIMSGQTDVDHPLCEECTDTLLDQLDTQLNVTENECQNYKRCLEILEQMNEDDSEQL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 QMELKELALEEERLIQELEDVEKNRKIVAENLEKVQAEAERLDQEEAQYQREYSEFKRQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QMELKELALEEERLIQELEDVEKNRKIVAENLEKVQAEAERLDQEEAQYQREYSEFKRQQ 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 LELDDELKSVENQMRYAQTQLDKLKKTNVFNATFHIWHSGQFGTINNFRLGRLPSVPVEW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LELDDELKSVENQMRYAQTQLDKLKKTNVFNATFHIWHSGQFGTINNFRLGRLPSVPVEW 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 NEINAAWGQTVLLLHALANKMGLKFQRYRLVPYGNHSYLESLTDKSKELPLYCSGGLRFF ::::::::::::::::::::::::::: XP_005 NEINAAWGQTVLLLHALANKMGLKFQR--------------------------------- 310 320 370 380 390 400 410 420 pF1KE4 WDNKFDHAMVAFLDCVQQFKEEVEKGETRFCLPYRMDVEKGKIEDTGGSGGSYSIKTQFN ::::::::::::::::::::::::: XP_005 -----------------------------------MDVEKGKIEDTGGSGGSYSIKTQFN 330 340 350 430 440 450 pF1KE4 SEEQWTKALKFMLTNLKWGLAWVSSQFYNK :::::::::::::::::::::::::::::: XP_005 SEEQWTKALKFMLTNLKWGLAWVSSQFYNK 360 370 380 >>NP_001277622 (OMIM: 615687) beclin-2 [Homo sapiens] (431 aa) initn: 1539 init1: 1146 opt: 1559 Z-score: 980.7 bits: 190.6 E(85289): 6.9e-48 Smith-Waterman score: 1559; 56.1% identity (76.8% similar) in 435 aa overlap (14-447:4-429) 10 20 30 40 50 60 pF1KE4 MEGSKTSNNSTMQVSFVCQRCSQPLKLDTSFKILDRVTIQELTAPLLTTAQAKPGETQEE . :.:::: : :::. : . .. :: :..::.::.:.: NP_001 MSSIRFLCQRCHQALKLSGS---SESRSLPAAPAP--TSGQAEPGDTREP 10 20 30 40 70 80 90 100 110 120 pF1KE4 ETNSGEEPFIETPRQDGVSRRFIPPARMMSTESANSFTLIGEASDGGTMENLSRRLKVTG ... : : .:::.: : : .: :: :::.:: :.:. :: :..: NP_001 GVTTREVTDAEE-QQDGASSRSPPGDGSVSKGHANIFTLLGEL---GAMHMLSSIQKAAG 50 60 70 80 90 100 130 140 150 160 170 pF1KE4 DLFDIMSGQTDVDHPLCEECTDTLLDQLDTQLNVTENECQNYKRCLEILE-QMNEDDSEQ :.:::.:::. :::::::::::.::.::: :: .:: . :::.:::: : .::.. NP_001 DIFDIVSGQAVVDHPLCEECTDSLLEQLDIQLALTEADSQNYQRCLETGELATSEDEAAA 110 120 130 140 150 160 180 190 200 210 220 230 pF1KE4 LQMELKELALEEERLIQELEDVEKNRKIVAENLEKVQAEAERLDQEEAQYQREYSEFKRQ :. ::..: ::: ::.::::::..: .: .:. .:::: .:::.: :. :.:: .::: NP_001 LRAELRDLELEEARLVQELEDVDRNNARAAADLQAAQAEAAELDQQERQHYRDYSALKRQ 170 180 190 200 210 220 240 250 260 270 280 290 pF1KE4 QLELDDELKSVENQMRYAQTQLDKLKKTNVFNATFHIWHSGQFGTINNFRLGRLPSVPVE :::: :.: .::::..::..: :.::. : :.:::.:: : .:.::::::::::.: : NP_001 QLELLDQLGNVENQLQYARVQRDRLKEINCFTATFEIWVEGPLGVINNFRLGRLPTVRVG 230 240 250 260 270 280 300 310 320 330 340 350 pF1KE4 WNEINAAWGQTVLLLHALANKMGLKFQRYRLVPYGNHSYLESLTDKSKELPLYCSGGLRF :::::.::::..::: .::: .::.::::::.: ::::::.:::: ::::.: :: NP_001 WNEINTAWGQAALLLLTLANTIGLQFQRYRLIPCGNHSYLKSLTDDRTELPLFCYGGQDV 290 300 310 320 330 340 360 370 380 390 400 410 pF1KE4 FWDNKFDHAMVAFLDCVQQFKEEVEKGETRFCLPYRMDVEKGKIEDTGGSGGSYSIKTQF : .::.:.::::::::.::::::.:::: . ::: ..:: : .::.:: : :::.:.. NP_001 FLNNKYDRAMVAFLDCMQQFKEEAEKGELGLSLPYGIQVETGLMEDVGGRGECYSIRTHL 350 360 370 380 390 400 420 430 440 450 pF1KE4 NSEEQWTKALKFMLTNLKWGLAWVSSQFYNK :..: ::::::::: :.::.: ::.:.. NP_001 NTQELWTKALKFMLINFKWSLIWVASRYQK 410 420 430 450 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 00:39:46 2016 done: Sun Nov 6 00:39:47 2016 Total Scan time: 9.370 Total Display time: 0.060 Function used was FASTA [36.3.4 Apr, 2011]