Result of FASTA (omim) for
pFN21AE1303
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE1303, 416 aa
1>>>pF1KE1303 416 - 416 aa - 416 aa
Library: /omim/omim.rfq.tfa
61989856 residues in 87180 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.8083+/-0.000309; mu= 15.1621+/- 0.019
mean_var=80.9249+/-16.566, 0's: 0 Z-trim(117.0): 73 B-trim: 1503 in 1/49
Lambda= 0.142572
statistics sampled from 28889 (28983) to 28889 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.706), E-opt: 0.2 (0.332), width: 16
Scan time: 9.360
The best scores are: opt bits E(87180)
NP_001220 (OMIM: 602234) caspase-9 isoform alpha p ( 416) 2819 589.3 5.9e-168
XP_011540575 (OMIM: 602234) PREDICTED: caspase-9 i ( 421) 2641 552.7 6.3e-157
XP_005246071 (OMIM: 602234) PREDICTED: caspase-9 i ( 333) 2267 475.7 7.4e-134
NP_127463 (OMIM: 602234) caspase-9 isoform 3 [Homo ( 333) 2267 475.7 7.4e-134
NP_001264983 (OMIM: 602234) caspase-9 isoform beta ( 266) 918 198.2 2.1e-50
NP_116764 (OMIM: 600639) caspase-2 isoform 1 prepr ( 452) 437 99.4 2e-20
NP_001215 (OMIM: 600639) caspase-2 isoform 2 [Homo ( 312) 402 92.1 2.1e-18
NP_116786 (OMIM: 600636) caspase-3 preproprotein [ ( 277) 392 90.0 8e-18
NP_004337 (OMIM: 600636) caspase-3 preproprotein [ ( 277) 392 90.0 8e-18
XP_011530603 (OMIM: 600636) PREDICTED: caspase-3 i ( 277) 392 90.0 8e-18
XP_005246951 (OMIM: 114480,114550,211980,601763,60 ( 280) 392 90.0 8e-18
XP_011510271 (OMIM: 114480,114550,211980,601763,60 ( 334) 391 89.9 1.1e-17
NP_203520 (OMIM: 114480,114550,211980,601763,60727 ( 464) 391 89.9 1.4e-17
NP_001073593 (OMIM: 114480,114550,211980,601763,60 ( 464) 391 89.9 1.4e-17
XP_005246949 (OMIM: 114480,114550,211980,601763,60 ( 464) 391 89.9 1.4e-17
XP_005246944 (OMIM: 114480,114550,211980,601763,60 ( 479) 391 90.0 1.4e-17
XP_006712853 (OMIM: 114480,114550,211980,601763,60 ( 479) 391 90.0 1.4e-17
XP_005246946 (OMIM: 114480,114550,211980,601763,60 ( 479) 391 90.0 1.4e-17
NP_203519 (OMIM: 114480,114550,211980,601763,60727 ( 479) 391 90.0 1.4e-17
XP_005246947 (OMIM: 114480,114550,211980,601763,60 ( 479) 391 90.0 1.4e-17
XP_005246945 (OMIM: 114480,114550,211980,601763,60 ( 479) 391 90.0 1.4e-17
XP_005246948 (OMIM: 114480,114550,211980,601763,60 ( 479) 391 90.0 1.4e-17
XP_005246943 (OMIM: 114480,114550,211980,601763,60 ( 479) 391 90.0 1.4e-17
XP_006712852 (OMIM: 114480,114550,211980,601763,60 ( 479) 391 90.0 1.4e-17
NP_001219 (OMIM: 114480,114550,211980,601763,60727 ( 496) 391 90.0 1.5e-17
XP_005246942 (OMIM: 114480,114550,211980,601763,60 ( 523) 391 90.0 1.6e-17
NP_001073594 (OMIM: 114480,114550,211980,601763,60 ( 538) 391 90.0 1.6e-17
XP_016872253 (OMIM: 601761) PREDICTED: caspase-7 i ( 311) 321 75.5 2.2e-13
NP_001307840 (OMIM: 601761) caspase-7 isoform g [H ( 311) 321 75.5 2.2e-13
XP_006718080 (OMIM: 601761) PREDICTED: caspase-7 i ( 317) 321 75.5 2.2e-13
XP_011538562 (OMIM: 601761) PREDICTED: caspase-7 i ( 270) 320 75.2 2.2e-13
NP_001253987 (OMIM: 601761) caspase-7 isoform f [H ( 278) 320 75.2 2.3e-13
NP_001218 (OMIM: 601761) caspase-7 isoform alpha p ( 303) 320 75.2 2.5e-13
NP_203125 (OMIM: 601761) caspase-7 isoform alpha p ( 303) 320 75.2 2.5e-13
NP_001253985 (OMIM: 601761) caspase-7 isoform alph ( 303) 320 75.2 2.5e-13
XP_016872252 (OMIM: 601761) PREDICTED: caspase-7 i ( 322) 320 75.3 2.6e-13
NP_001253986 (OMIM: 601761) caspase-7 isoform e [H ( 388) 321 75.5 2.6e-13
NP_203124 (OMIM: 601761) caspase-7 isoform delta [ ( 336) 320 75.3 2.7e-13
NP_001217 (OMIM: 601532) caspase-6 isoform alpha p ( 293) 286 68.2 3.1e-11
NP_001193471 (OMIM: 601762,603909,605027,613659) c ( 478) 270 65.1 4.5e-10
NP_001221 (OMIM: 601762,603909,605027,613659) casp ( 479) 270 65.1 4.5e-10
XP_006712859 (OMIM: 601762,603909,605027,613659) P ( 272) 263 63.5 7.6e-10
XP_005246964 (OMIM: 601762,603909,605027,613659) P ( 521) 263 63.7 1.3e-09
NP_116756 (OMIM: 601762,603909,605027,613659) casp ( 521) 263 63.7 1.3e-09
NP_116759 (OMIM: 601762,603909,605027,613659) casp ( 522) 263 63.7 1.3e-09
NP_001193453 (OMIM: 601762,603909,605027,613659) c ( 455) 232 57.2 9.7e-08
XP_011526163 (OMIM: 605848,617320) PREDICTED: casp ( 230) 224 55.4 1.7e-07
NP_036246 (OMIM: 605848,617320) caspase-14 precurs ( 242) 216 53.8 5.6e-07
NP_150636 (OMIM: 147678) caspase-1 isoform delta [ ( 263) 212 53.0 1.1e-06
NP_001129581 (OMIM: 602665) caspase-5 isoform b pr ( 376) 203 51.2 5.2e-06
>>NP_001220 (OMIM: 602234) caspase-9 isoform alpha precu (416 aa)
initn: 2819 init1: 2819 opt: 2819 Z-score: 3136.5 bits: 589.3 E(87180): 5.9e-168
Smith-Waterman score: 2819; 100.0% identity (100.0% similar) in 416 aa overlap (1-416:1-416)
10 20 30 40 50 60
pF1KE1 MDEADRRLLRRCRLRLVEELQVDQLWDALLSRELFRPHMIEDIQRAGSGSRRDQARQLII
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MDEADRRLLRRCRLRLVEELQVDQLWDALLSRELFRPHMIEDIQRAGSGSRRDQARQLII
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 DLETRGSQALPLFISCLEDTGQDMLASFLRTNRQAAKLSKPTLENLTPVVLRPEIRKPEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DLETRGSQALPLFISCLEDTGQDMLASFLRTNRQAAKLSKPTLENLTPVVLRPEIRKPEV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 LRPETPRPVDIGSGGFGDVGALESLRGNADLAYILSMEPCGHCLIINNVNFCRESGLRTR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LRPETPRPVDIGSGGFGDVGALESLRGNADLAYILSMEPCGHCLIINNVNFCRESGLRTR
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE1 TGSNIDCEKLRRRFSSLHFMVEVKGDLTAKKMVLALLELAQQDHGALDCCVVVILSHGCQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TGSNIDCEKLRRRFSSLHFMVEVKGDLTAKKMVLALLELAQQDHGALDCCVVVILSHGCQ
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE1 ASHLQFPGAVYGTDGCPVSVEKIVNIFNGTSCPSLGGKPKLFFIQACGGEQKDHGFEVAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ASHLQFPGAVYGTDGCPVSVEKIVNIFNGTSCPSLGGKPKLFFIQACGGEQKDHGFEVAS
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE1 TSPEDESPGSNPEPDATPFQEGLRTFDQLDAISSLPTPSDIFVSYSTFPGFVSWRDPKSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TSPEDESPGSNPEPDATPFQEGLRTFDQLDAISSLPTPSDIFVSYSTFPGFVSWRDPKSG
310 320 330 340 350 360
370 380 390 400 410
pF1KE1 SWYVETLDDIFEQWAHSEDLQSLLLRVANAVSVKGIYKQMPGCFNFLRKKLFFKTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SWYVETLDDIFEQWAHSEDLQSLLLRVANAVSVKGIYKQMPGCFNFLRKKLFFKTS
370 380 390 400 410
>>XP_011540575 (OMIM: 602234) PREDICTED: caspase-9 isofo (421 aa)
initn: 2639 init1: 2639 opt: 2641 Z-score: 2938.5 bits: 552.7 E(87180): 6.3e-157
Smith-Waterman score: 2641; 97.3% identity (98.0% similar) in 402 aa overlap (1-402:1-402)
10 20 30 40 50 60
pF1KE1 MDEADRRLLRRCRLRLVEELQVDQLWDALLSRELFRPHMIEDIQRAGSGSRRDQARQLII
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MDEADRRLLRRCRLRLVEELQVDQLWDALLSRELFRPHMIEDIQRAGSGSRRDQARQLII
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 DLETRGSQALPLFISCLEDTGQDMLASFLRTNRQAAKLSKPTLENLTPVVLRPEIRKPEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DLETRGSQALPLFISCLEDTGQDMLASFLRTNRQAAKLSKPTLENLTPVVLRPEIRKPEV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 LRPETPRPVDIGSGGFGDVGALESLRGNADLAYILSMEPCGHCLIINNVNFCRESGLRTR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LRPETPRPVDIGSGGFGDVGALESLRGNADLAYILSMEPCGHCLIINNVNFCRESGLRTR
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE1 TGSNIDCEKLRRRFSSLHFMVEVKGDLTAKKMVLALLELAQQDHGALDCCVVVILSHGCQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TGSNIDCEKLRRRFSSLHFMVEVKGDLTAKKMVLALLELAQQDHGALDCCVVVILSHGCQ
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE1 ASHLQFPGAVYGTDGCPVSVEKIVNIFNGTSCPSLGGKPKLFFIQACGGEQKDHGFEVAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ASHLQFPGAVYGTDGCPVSVEKIVNIFNGTSCPSLGGKPKLFFIQACGGEQKDHGFEVAS
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE1 TSPEDESPGSNPEPDATPFQEGLRTFDQLDAISSLPTPSDIFVSYSTFPGFVSWRDPKSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TSPEDESPGSNPEPDATPFQEGLRTFDQLDAISSLPTPSDIFVSYSTFPGFVSWRDPKSG
310 320 330 340 350 360
370 380 390 400 410
pF1KE1 SWYVETLDDIFEQWAHSEDLQSLLLRVANAVSVKGIYKQMPGCFNFLRKKLFFKTS
:::::::::::::::::::::::::::. : :: . . :
XP_011 SWYVETLDDIFEQWAHSEDLQSLLLRVSAAFLCKGEGRLLRGSVSSWGWGFGVSRAGPNQ
370 380 390 400 410 420
XP_011 G
>>XP_005246071 (OMIM: 602234) PREDICTED: caspase-9 isofo (333 aa)
initn: 2267 init1: 2267 opt: 2267 Z-score: 2524.3 bits: 475.7 E(87180): 7.4e-134
Smith-Waterman score: 2267; 100.0% identity (100.0% similar) in 333 aa overlap (84-416:1-333)
60 70 80 90 100 110
pF1KE1 QARQLIIDLETRGSQALPLFISCLEDTGQDMLASFLRTNRQAAKLSKPTLENLTPVVLRP
::::::::::::::::::::::::::::::
XP_005 MLASFLRTNRQAAKLSKPTLENLTPVVLRP
10 20 30
120 130 140 150 160 170
pF1KE1 EIRKPEVLRPETPRPVDIGSGGFGDVGALESLRGNADLAYILSMEPCGHCLIINNVNFCR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EIRKPEVLRPETPRPVDIGSGGFGDVGALESLRGNADLAYILSMEPCGHCLIINNVNFCR
40 50 60 70 80 90
180 190 200 210 220 230
pF1KE1 ESGLRTRTGSNIDCEKLRRRFSSLHFMVEVKGDLTAKKMVLALLELAQQDHGALDCCVVV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ESGLRTRTGSNIDCEKLRRRFSSLHFMVEVKGDLTAKKMVLALLELAQQDHGALDCCVVV
100 110 120 130 140 150
240 250 260 270 280 290
pF1KE1 ILSHGCQASHLQFPGAVYGTDGCPVSVEKIVNIFNGTSCPSLGGKPKLFFIQACGGEQKD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ILSHGCQASHLQFPGAVYGTDGCPVSVEKIVNIFNGTSCPSLGGKPKLFFIQACGGEQKD
160 170 180 190 200 210
300 310 320 330 340 350
pF1KE1 HGFEVASTSPEDESPGSNPEPDATPFQEGLRTFDQLDAISSLPTPSDIFVSYSTFPGFVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 HGFEVASTSPEDESPGSNPEPDATPFQEGLRTFDQLDAISSLPTPSDIFVSYSTFPGFVS
220 230 240 250 260 270
360 370 380 390 400 410
pF1KE1 WRDPKSGSWYVETLDDIFEQWAHSEDLQSLLLRVANAVSVKGIYKQMPGCFNFLRKKLFF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 WRDPKSGSWYVETLDDIFEQWAHSEDLQSLLLRVANAVSVKGIYKQMPGCFNFLRKKLFF
280 290 300 310 320 330
pF1KE1 KTS
:::
XP_005 KTS
>>NP_127463 (OMIM: 602234) caspase-9 isoform 3 [Homo sap (333 aa)
initn: 2267 init1: 2267 opt: 2267 Z-score: 2524.3 bits: 475.7 E(87180): 7.4e-134
Smith-Waterman score: 2267; 100.0% identity (100.0% similar) in 333 aa overlap (84-416:1-333)
60 70 80 90 100 110
pF1KE1 QARQLIIDLETRGSQALPLFISCLEDTGQDMLASFLRTNRQAAKLSKPTLENLTPVVLRP
::::::::::::::::::::::::::::::
NP_127 MLASFLRTNRQAAKLSKPTLENLTPVVLRP
10 20 30
120 130 140 150 160 170
pF1KE1 EIRKPEVLRPETPRPVDIGSGGFGDVGALESLRGNADLAYILSMEPCGHCLIINNVNFCR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_127 EIRKPEVLRPETPRPVDIGSGGFGDVGALESLRGNADLAYILSMEPCGHCLIINNVNFCR
40 50 60 70 80 90
180 190 200 210 220 230
pF1KE1 ESGLRTRTGSNIDCEKLRRRFSSLHFMVEVKGDLTAKKMVLALLELAQQDHGALDCCVVV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_127 ESGLRTRTGSNIDCEKLRRRFSSLHFMVEVKGDLTAKKMVLALLELAQQDHGALDCCVVV
100 110 120 130 140 150
240 250 260 270 280 290
pF1KE1 ILSHGCQASHLQFPGAVYGTDGCPVSVEKIVNIFNGTSCPSLGGKPKLFFIQACGGEQKD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_127 ILSHGCQASHLQFPGAVYGTDGCPVSVEKIVNIFNGTSCPSLGGKPKLFFIQACGGEQKD
160 170 180 190 200 210
300 310 320 330 340 350
pF1KE1 HGFEVASTSPEDESPGSNPEPDATPFQEGLRTFDQLDAISSLPTPSDIFVSYSTFPGFVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_127 HGFEVASTSPEDESPGSNPEPDATPFQEGLRTFDQLDAISSLPTPSDIFVSYSTFPGFVS
220 230 240 250 260 270
360 370 380 390 400 410
pF1KE1 WRDPKSGSWYVETLDDIFEQWAHSEDLQSLLLRVANAVSVKGIYKQMPGCFNFLRKKLFF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_127 WRDPKSGSWYVETLDDIFEQWAHSEDLQSLLLRVANAVSVKGIYKQMPGCFNFLRKKLFF
280 290 300 310 320 330
pF1KE1 KTS
:::
NP_127 KTS
>>NP_001264983 (OMIM: 602234) caspase-9 isoform beta [Ho (266 aa)
initn: 1774 init1: 918 opt: 918 Z-score: 1026.2 bits: 198.2 E(87180): 2.1e-50
Smith-Waterman score: 1478; 63.9% identity (63.9% similar) in 416 aa overlap (1-416:1-266)
10 20 30 40 50 60
pF1KE1 MDEADRRLLRRCRLRLVEELQVDQLWDALLSRELFRPHMIEDIQRAGSGSRRDQARQLII
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MDEADRRLLRRCRLRLVEELQVDQLWDALLSRELFRPHMIEDIQRAGSGSRRDQARQLII
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 DLETRGSQALPLFISCLEDTGQDMLASFLRTNRQAAKLSKPTLENLTPVVLRPEIRKPEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DLETRGSQALPLFISCLEDTGQDMLASFLRTNRQAAKLSKPTLENLTPVVLRPEIRKPEV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 LRPETPRPVDIGSGGFGDVGALESLRGNADLAYILSMEPCGHCLIINNVNFCRESGLRTR
:::::::::::::::::::
NP_001 LRPETPRPVDIGSGGFGDV-----------------------------------------
130
190 200 210 220 230 240
pF1KE1 TGSNIDCEKLRRRFSSLHFMVEVKGDLTAKKMVLALLELAQQDHGALDCCVVVILSHGCQ
NP_001 ------------------------------------------------------------
250 260 270 280 290 300
pF1KE1 ASHLQFPGAVYGTDGCPVSVEKIVNIFNGTSCPSLGGKPKLFFIQACGGEQKDHGFEVAS
:::::::::::
NP_001 -------------------------------------------------EQKDHGFEVAS
140 150
310 320 330 340 350 360
pF1KE1 TSPEDESPGSNPEPDATPFQEGLRTFDQLDAISSLPTPSDIFVSYSTFPGFVSWRDPKSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TSPEDESPGSNPEPDATPFQEGLRTFDQLDAISSLPTPSDIFVSYSTFPGFVSWRDPKSG
160 170 180 190 200 210
370 380 390 400 410
pF1KE1 SWYVETLDDIFEQWAHSEDLQSLLLRVANAVSVKGIYKQMPGCFNFLRKKLFFKTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SWYVETLDDIFEQWAHSEDLQSLLLRVANAVSVKGIYKQMPGCFNFLRKKLFFKTS
220 230 240 250 260
>>NP_116764 (OMIM: 600639) caspase-2 isoform 1 prepropro (452 aa)
initn: 308 init1: 200 opt: 437 Z-score: 488.0 bits: 99.4 E(87180): 2e-20
Smith-Waterman score: 548; 31.3% identity (59.0% similar) in 422 aa overlap (1-410:32-430)
10 20 30
pF1KE1 MDEADRRLLRRCRLRLVEELQVDQLWDALL
: .. :.. :. :...: ...: . ::
NP_116 AAPSAGSWSTFQHKELMAADRGRRILGVCGMHPHHQETLKKNRVVLAKQLLLSELLEHLL
10 20 30 40 50 60
40 50 60 70 80
pF1KE1 SRELFRPHMIEDIQ-RAGSGSRRDQARQLIIDLETRGSQALPLFISCLEDTGQDMLASFL
.... .: : :: ..:: : : .:. : :: ::. : :..: : : ..:
NP_116 EKDIITLEMRELIQAKVGSFS---QNVELLNLLPKRGPQAFDAFCEALRETKQGHLEDML
70 80 90 100 110
90 100 110 120 130 140
pF1KE1 RTNRQAAKLSKPTLE---NLT---PVVLR-PEIRKPEVLRPETPRPVDIGSGGFG-DVGA
:. .. . : : .:. :: : .: .. . . .: .: .:
NP_116 LTTLSGLQHVLPPLSCDYDLSLPFPVCESCPLYKKLRLSTDTVEHSLDNKDGPVCLQVKP
120 130 140 150 160 170
150 160 170 180 190
pF1KE1 L--ESLRGNADLAYILSMEPCGHCLIINNVNFCRESGLRTRTGSNIDCEKLRRRFSSLHF
: . . .::: :. .: : :...::.: :. :. :.:...: : :. : .
NP_116 CTPEFYQTHFQLAYRLQSRPRGLALVLSNVHFTGEKELEFRSGGDVDHSTLVTLFKLLGY
180 190 200 210 220 230
200 210 220 230 240 250
pF1KE1 MVEVKGDLTAKKMVLALLELAQQD-HGALDCCVVVILSHGCQASHLQFPGAVYGTDGCPV
:.: : ::..: : ..:: : . : :.:..:::: . ::.::.:: .
NP_116 DVHVLCDQTAQEMQEKLQNFAQLPAHRVTDSCIVALLSHGVE-------GAIYGVDGKLL
240 250 260 270 280 290
260 270 280 290 300 310
pF1KE1 SVEKIVNIFNGTSCPSLGGKPKLFFIQACGGEQKDHGFEVASTSPEDESPGSNPEPDATP
..... ..:....:::: .:::.:::::: :.. :.: . . . . ::: . : ::
NP_116 QLQEVFQLFDNANCPSLQNKPKMFFIQACRGDETDRGVDQQDGKNHAGSPGCE-ESDA--
300 310 320 330 340
320 330 340 350 360 370
pF1KE1 FQEGLRTFDQLDAISSLPTPSDIFVSYSTFPGFVSWRDPKSGSWYVETLDDIFEQWAHSE
: . . .. ::: ::.. .:. . : .. :. : ::::.:.: ..: . : .
NP_116 ---GKEKLPKM----RLPTRSDMICGYACLKGTAAMRNTKRGSWYIEALAQVFSERACDM
350 360 370 380 390 400
380 390 400 410
pF1KE1 DLQSLLLRVANAVSVKGIYKQMPGCFNFLRKKLFFKTS
. ..:..: ::. .: :: .: : :
NP_116 HVADMLVKV-NAL-IKDREGYAPGT-EFHRCKEMSEYCSTLCRHLYLFPGHPPT
410 420 430 440 450
>>NP_001215 (OMIM: 600639) caspase-2 isoform 2 [Homo sap (312 aa)
initn: 170 init1: 170 opt: 402 Z-score: 451.5 bits: 92.1 E(87180): 2.1e-18
Smith-Waterman score: 402; 31.9% identity (59.5% similar) in 301 aa overlap (1-289:1-291)
10 20 30 40 50
pF1KE1 MDEADRRLLRRCRLRLVEELQVDQLWDALLSRELFRPHMIEDIQ-RAGSGSRRDQARQLI
: .. :.. :. :...: ...: . :: .... .: : :: ..:: : : .:.
NP_001 MHPHHQETLKKNRVVLAKQLLLSELLEHLLEKDIITLEMRELIQAKVGSFS---QNVELL
10 20 30 40 50
60 70 80 90 100 110
pF1KE1 IDLETRGSQALPLFISCLEDTGQDMLASFLRTNRQAAKLSKPTLE---NLT---PVVLR-
: :: ::. : :..: : : ..: :. .. . : : .:. ::
NP_001 NLLPKRGPQAFDAFCEALRETKQGHLEDMLLTTLSGLQHVLPPLSCDYDLSLPFPVCESC
60 70 80 90 100 110
120 130 140 150 160
pF1KE1 PEIRKPEVLRPETPRPVDIGSGGFG-DVGAL--ESLRGNADLAYILSMEPCGHCLIINNV
: .: .. . . .: .: .: : . . .::: :. .: : :...::
NP_001 PLYKKLRLSTDTVEHSLDNKDGPVCLQVKPCTPEFYQTHFQLAYRLQSRPRGLALVLSNV
120 130 140 150 160 170
170 180 190 200 210 220
pF1KE1 NFCRESGLRTRTGSNIDCEKLRRRFSSLHFMVEVKGDLTAKKMVLALLELAQQD-HGALD
.: :. :. :.:...: : :. : . :.: : ::..: : ..:: : . :
NP_001 HFTGEKELEFRSGGDVDHSTLVTLFKLLGYDVHVLCDQTAQEMQEKLQNFAQLPAHRVTD
180 190 200 210 220 230
230 240 250 260 270 280
pF1KE1 CCVVVILSHGCQASHLQFPGAVYGTDGCPVSVEKIVNIFNGTSCPSLGGKPKLFFIQACG
:.:..:::: . ::.::.:: ...... ..:....:::: .:::.::::::
NP_001 SCIVALLSHGVE-------GAIYGVDGKLLQLQEVFQLFDNANCPSLQNKPKMFFIQACR
240 250 260 270 280 290
290 300 310 320 330 340
pF1KE1 GEQKDHGFEVASTSPEDESPGSNPEPDATPFQEGLRTFDQLDAISSLPTPSDIFVSYSTF
:
NP_001 GGAIGSLGHLLLFTAATASLAL
300 310
>>NP_116786 (OMIM: 600636) caspase-3 preproprotein [Homo (277 aa)
initn: 509 init1: 221 opt: 392 Z-score: 441.2 bits: 90.0 E(87180): 8e-18
Smith-Waterman score: 514; 33.2% identity (61.3% similar) in 274 aa overlap (150-413:34-275)
120 130 140 150 160 170
pF1KE1 VLRPETPRPVDIGSGGFGDVGALESLRGNADLAYILSMEPCGHCLIINNVNFCRESGLRT
: .: ... : :.:::: :: . .:. .
NP_116 TENSVDSKSIKNLEPKIIHGSESMDSGISLDNSYKMDYPEMGLCIIINNKNFHKSTGMTS
10 20 30 40 50 60
180 190 200 210 220 230
pF1KE1 RTGSNIDCEKLRRRFSSLHFMVEVKGDLTAKKMVLALLELAQQDHGALDCCVVVILSHGC
:.:...: .::. : .:.. :. :.::: ...: . .....::. . : :.::::
NP_116 RSGTDVDAANLRETFRNLKYEVRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLSHGE
70 80 90 100 110 120
240 250 260 270 280 290
pF1KE1 QASHLQFPGAVYGTDGCPVSVEKIVNIFNGTSCPSLGGKPKLFFIQACGGEQKDHGFEVA
. : ..::.: ::...::.:.: : : :: ::::::.:::: : . : :.:.
NP_116 E-------GIIFGTNG-PVDLKKITNFFRGDRCRSLTGKPKLFIIQACRGTELDCGIETD
130 140 150 160 170
300 310 320 330 340 350
pF1KE1 STSPEDESPGSNPEPDATPFQEGLRTFDQLDAISSLPTPSDIFVSYSTFPGFVSWRDPKS
: .: : ..:. .:.. .::: ::. :::. :.
NP_116 SGVDDDM------------------------ACHKIPVEADFLYAYSTAPGYYSWRNSKD
180 190 200 210
360 370 380 390 400
pF1KE1 GSWYVETLDDIFEQWAHSEDLQSLLLRVANAVSVK----------GIYKQMPGCFNFLRK
:::....: ...:.: . ... .: :: :... ::.: ..: :
NP_116 GSWFIQSLCAMLKQYADKLEFMHILTRVNRKVATEFESFSFDATFHAKKQIPCIVSMLTK
220 230 240 250 260 270
410
pF1KE1 KLFFKTS
.:.:
NP_116 ELYFYH
>>NP_004337 (OMIM: 600636) caspase-3 preproprotein [Homo (277 aa)
initn: 509 init1: 221 opt: 392 Z-score: 441.2 bits: 90.0 E(87180): 8e-18
Smith-Waterman score: 514; 33.2% identity (61.3% similar) in 274 aa overlap (150-413:34-275)
120 130 140 150 160 170
pF1KE1 VLRPETPRPVDIGSGGFGDVGALESLRGNADLAYILSMEPCGHCLIINNVNFCRESGLRT
: .: ... : :.:::: :: . .:. .
NP_004 TENSVDSKSIKNLEPKIIHGSESMDSGISLDNSYKMDYPEMGLCIIINNKNFHKSTGMTS
10 20 30 40 50 60
180 190 200 210 220 230
pF1KE1 RTGSNIDCEKLRRRFSSLHFMVEVKGDLTAKKMVLALLELAQQDHGALDCCVVVILSHGC
:.:...: .::. : .:.. :. :.::: ...: . .....::. . : :.::::
NP_004 RSGTDVDAANLRETFRNLKYEVRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLSHGE
70 80 90 100 110 120
240 250 260 270 280 290
pF1KE1 QASHLQFPGAVYGTDGCPVSVEKIVNIFNGTSCPSLGGKPKLFFIQACGGEQKDHGFEVA
. : ..::.: ::...::.:.: : : :: ::::::.:::: : . : :.:.
NP_004 E-------GIIFGTNG-PVDLKKITNFFRGDRCRSLTGKPKLFIIQACRGTELDCGIETD
130 140 150 160 170
300 310 320 330 340 350
pF1KE1 STSPEDESPGSNPEPDATPFQEGLRTFDQLDAISSLPTPSDIFVSYSTFPGFVSWRDPKS
: .: : ..:. .:.. .::: ::. :::. :.
NP_004 SGVDDDM------------------------ACHKIPVEADFLYAYSTAPGYYSWRNSKD
180 190 200 210
360 370 380 390 400
pF1KE1 GSWYVETLDDIFEQWAHSEDLQSLLLRVANAVSVK----------GIYKQMPGCFNFLRK
:::....: ...:.: . ... .: :: :... ::.: ..: :
NP_004 GSWFIQSLCAMLKQYADKLEFMHILTRVNRKVATEFESFSFDATFHAKKQIPCIVSMLTK
220 230 240 250 260 270
410
pF1KE1 KLFFKTS
.:.:
NP_004 ELYFYH
>>XP_011530603 (OMIM: 600636) PREDICTED: caspase-3 isofo (277 aa)
initn: 509 init1: 221 opt: 392 Z-score: 441.2 bits: 90.0 E(87180): 8e-18
Smith-Waterman score: 514; 33.2% identity (61.3% similar) in 274 aa overlap (150-413:34-275)
120 130 140 150 160 170
pF1KE1 VLRPETPRPVDIGSGGFGDVGALESLRGNADLAYILSMEPCGHCLIINNVNFCRESGLRT
: .: ... : :.:::: :: . .:. .
XP_011 TENSVDSKSIKNLEPKIIHGSESMDSGISLDNSYKMDYPEMGLCIIINNKNFHKSTGMTS
10 20 30 40 50 60
180 190 200 210 220 230
pF1KE1 RTGSNIDCEKLRRRFSSLHFMVEVKGDLTAKKMVLALLELAQQDHGALDCCVVVILSHGC
:.:...: .::. : .:.. :. :.::: ...: . .....::. . : :.::::
XP_011 RSGTDVDAANLRETFRNLKYEVRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLSHGE
70 80 90 100 110 120
240 250 260 270 280 290
pF1KE1 QASHLQFPGAVYGTDGCPVSVEKIVNIFNGTSCPSLGGKPKLFFIQACGGEQKDHGFEVA
. : ..::.: ::...::.:.: : : :: ::::::.:::: : . : :.:.
XP_011 E-------GIIFGTNG-PVDLKKITNFFRGDRCRSLTGKPKLFIIQACRGTELDCGIETD
130 140 150 160 170
300 310 320 330 340 350
pF1KE1 STSPEDESPGSNPEPDATPFQEGLRTFDQLDAISSLPTPSDIFVSYSTFPGFVSWRDPKS
: .: : ..:. .:.. .::: ::. :::. :.
XP_011 SGVDDDM------------------------ACHKIPVEADFLYAYSTAPGYYSWRNSKD
180 190 200 210
360 370 380 390 400
pF1KE1 GSWYVETLDDIFEQWAHSEDLQSLLLRVANAVSVK----------GIYKQMPGCFNFLRK
:::....: ...:.: . ... .: :: :... ::.: ..: :
XP_011 GSWFIQSLCAMLKQYADKLEFMHILTRVNRKVATEFESFSFDATFHAKKQIPCIVSMLTK
220 230 240 250 260 270
410
pF1KE1 KLFFKTS
.:.:
XP_011 ELYFYH
416 residues in 1 query sequences
61989856 residues in 87180 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Mon May 22 10:33:29 2017 done: Mon May 22 10:33:30 2017
Total Scan time: 9.360 Total Display time: 0.050
Function used was FASTA [36.3.4 Apr, 2011]