FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE4440, 457 aa 1>>>pF1KE4440 457 - 457 aa - 457 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 10.7272+/-0.000382; mu= -6.6237+/- 0.024 mean_var=310.9435+/-61.020, 0's: 0 Z-trim(122.7): 12 B-trim: 0 in 0/57 Lambda= 0.072733 statistics sampled from 41353 (41374) to 41353 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.785), E-opt: 0.2 (0.485), width: 16 Scan time: 12.370 The best scores are: opt bits E(85289) NP_001266 (OMIM: 118910) chromogranin-A isoform 1 ( 457) 2994 327.5 4.6e-89 XP_011534672 (OMIM: 118910) PREDICTED: chromograni ( 457) 2994 327.5 4.6e-89 NP_001288619 (OMIM: 118910) chromogranin-A isoform ( 306) 1237 143.0 1.1e-33 NP_001030025 (OMIM: 300029,300455,300834,304020,31 (1152) 322 47.4 0.00024 >>NP_001266 (OMIM: 118910) chromogranin-A isoform 1 prep (457 aa) initn: 2994 init1: 2994 opt: 2994 Z-score: 1720.0 bits: 327.5 E(85289): 4.6e-89 Smith-Waterman score: 2994; 100.0% identity (100.0% similar) in 457 aa overlap (1-457:1-457) 10 20 30 40 50 60 pF1KE4 MRSAAVLALLLCAGQVTALPVNSPMNKGDTEVMKCIVEVISDTLSKPSPMPVSQECFETL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MRSAAVLALLLCAGQVTALPVNSPMNKGDTEVMKCIVEVISDTLSKPSPMPVSQECFETL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 RGDERILSILRHQNLLKELQDLALQGAKERAHQQKKHSGFEDELSEVLENQSSQAELKEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RGDERILSILRHQNLLKELQDLALQGAKERAHQQKKHSGFEDELSEVLENQSSQAELKEA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 VEEPSSKDVMEKREDSKEAEKSGEATDGARPQALPEPMQESKAEGNNQAPGEEEEEEEEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VEEPSSKDVMEKREDSKEAEKSGEATDGARPQALPEPMQESKAEGNNQAPGEEEEEEEEA 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 TNTHPPASLPSQKYPGPQAEGDSEGLSQGLVDREKGLSAEPGWQAKREEEEEEEEEAEAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TNTHPPASLPSQKYPGPQAEGDSEGLSQGLVDREKGLSAEPGWQAKREEEEEEEEEAEAG 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 EEAVPEEEGPTVVLNPHPSLGYKEIRKGESRSEALAVDGAGKPGAEEAQDPEGKGEQEHS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EEAVPEEEGPTVVLNPHPSLGYKEIRKGESRSEALAVDGAGKPGAEEAQDPEGKGEQEHS 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 QQKEEEEEMAVVPQGLFRGGKSGELEQEEERLSKEWEDSKRWSKMDQLAKELTAEKRLEG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QQKEEEEEMAVVPQGLFRGGKSGELEQEEERLSKEWEDSKRWSKMDQLAKELTAEKRLEG 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE4 QEEEEDNRDSSMKLSFRARAYGFRGPGPQLRRGWRPSSREDSLEAGLPLQVRGYPEEKKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QEEEEDNRDSSMKLSFRARAYGFRGPGPQLRRGWRPSSREDSLEAGLPLQVRGYPEEKKE 370 380 390 400 410 420 430 440 450 pF1KE4 EEGSANRRPEDQELESLSAIEAELEKVAHQLQALRRG ::::::::::::::::::::::::::::::::::::: NP_001 EEGSANRRPEDQELESLSAIEAELEKVAHQLQALRRG 430 440 450 >>XP_011534672 (OMIM: 118910) PREDICTED: chromogranin-A (457 aa) initn: 2994 init1: 2994 opt: 2994 Z-score: 1720.0 bits: 327.5 E(85289): 4.6e-89 Smith-Waterman score: 2994; 100.0% identity (100.0% similar) in 457 aa overlap (1-457:1-457) 10 20 30 40 50 60 pF1KE4 MRSAAVLALLLCAGQVTALPVNSPMNKGDTEVMKCIVEVISDTLSKPSPMPVSQECFETL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MRSAAVLALLLCAGQVTALPVNSPMNKGDTEVMKCIVEVISDTLSKPSPMPVSQECFETL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 RGDERILSILRHQNLLKELQDLALQGAKERAHQQKKHSGFEDELSEVLENQSSQAELKEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RGDERILSILRHQNLLKELQDLALQGAKERAHQQKKHSGFEDELSEVLENQSSQAELKEA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 VEEPSSKDVMEKREDSKEAEKSGEATDGARPQALPEPMQESKAEGNNQAPGEEEEEEEEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VEEPSSKDVMEKREDSKEAEKSGEATDGARPQALPEPMQESKAEGNNQAPGEEEEEEEEA 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 TNTHPPASLPSQKYPGPQAEGDSEGLSQGLVDREKGLSAEPGWQAKREEEEEEEEEAEAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TNTHPPASLPSQKYPGPQAEGDSEGLSQGLVDREKGLSAEPGWQAKREEEEEEEEEAEAG 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 EEAVPEEEGPTVVLNPHPSLGYKEIRKGESRSEALAVDGAGKPGAEEAQDPEGKGEQEHS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EEAVPEEEGPTVVLNPHPSLGYKEIRKGESRSEALAVDGAGKPGAEEAQDPEGKGEQEHS 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 QQKEEEEEMAVVPQGLFRGGKSGELEQEEERLSKEWEDSKRWSKMDQLAKELTAEKRLEG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QQKEEEEEMAVVPQGLFRGGKSGELEQEEERLSKEWEDSKRWSKMDQLAKELTAEKRLEG 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE4 QEEEEDNRDSSMKLSFRARAYGFRGPGPQLRRGWRPSSREDSLEAGLPLQVRGYPEEKKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QEEEEDNRDSSMKLSFRARAYGFRGPGPQLRRGWRPSSREDSLEAGLPLQVRGYPEEKKE 370 380 390 400 410 420 430 440 450 pF1KE4 EEGSANRRPEDQELESLSAIEAELEKVAHQLQALRRG ::::::::::::::::::::::::::::::::::::: XP_011 EEGSANRRPEDQELESLSAIEAELEKVAHQLQALRRG 430 440 450 >>NP_001288619 (OMIM: 118910) chromogranin-A isoform 2 p (306 aa) initn: 1237 init1: 1237 opt: 1237 Z-score: 726.1 bits: 143.0 E(85289): 1.1e-33 Smith-Waterman score: 1678; 66.7% identity (67.0% similar) in 457 aa overlap (1-457:1-306) 10 20 30 40 50 60 pF1KE4 MRSAAVLALLLCAGQVTALPVNSPMNKGDTEVMKCIVEVISDTLSKPSPMPVSQECFETL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MRSAAVLALLLCAGQVTALPVNSPMNKGDTEVMKCIVEVISDTLSKPSPMPVSQECFETL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 RGDERILSILRHQNLLKELQDLALQGAKERAHQQKKHSGFEDELSEVLENQSSQAELKEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RGDERILSILRHQNLLKELQDLALQGAKERAHQQKKHSGFEDELSEVLENQSSQAELK-- 70 80 90 100 110 130 140 150 160 170 180 pF1KE4 VEEPSSKDVMEKREDSKEAEKSGEATDGARPQALPEPMQESKAEGNNQAPGEEEEEEEEA NP_001 ------------------------------------------------------------ 190 200 210 220 230 240 pF1KE4 TNTHPPASLPSQKYPGPQAEGDSEGLSQGLVDREKGLSAEPGWQAKREEEEEEEEEAEAG NP_001 ------------------------------------------------------------ 250 260 270 280 290 300 pF1KE4 EEAVPEEEGPTVVLNPHPSLGYKEIRKGESRSEALAVDGAGKPGAEEAQDPEGKGEQEHS .:::::::::::::::::::::::::::::: NP_001 -----------------------------GRSEALAVDGAGKPGAEEAQDPEGKGEQEHS 120 130 140 310 320 330 340 350 360 pF1KE4 QQKEEEEEMAVVPQGLFRGGKSGELEQEEERLSKEWEDSKRWSKMDQLAKELTAEKRLEG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QQKEEEEEMAVVPQGLFRGGKSGELEQEEERLSKEWEDSKRWSKMDQLAKELTAEKRLEG 150 160 170 180 190 200 370 380 390 400 410 420 pF1KE4 QEEEEDNRDSSMKLSFRARAYGFRGPGPQLRRGWRPSSREDSLEAGLPLQVRGYPEEKKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QEEEEDNRDSSMKLSFRARAYGFRGPGPQLRRGWRPSSREDSLEAGLPLQVRGYPEEKKE 210 220 230 240 250 260 430 440 450 pF1KE4 EEGSANRRPEDQELESLSAIEAELEKVAHQLQALRRG ::::::::::::::::::::::::::::::::::::: NP_001 EEGSANRRPEDQELESLSAIEAELEKVAHQLQALRRG 270 280 290 300 >>NP_001030025 (OMIM: 300029,300455,300834,304020,312610 (1152 aa) initn: 296 init1: 175 opt: 322 Z-score: 199.1 bits: 47.4 E(85289): 0.00024 Smith-Waterman score: 322; 27.4% identity (55.1% similar) in 405 aa overlap (71-450:715-1101) 50 60 70 80 90 pF1KE4 SDTLSKPSPMPVSQECFETLRGDERILSILRHQNLLKEL-QDLALQGAKERAHQQKKHSG :.:. :: :.. : .:... ..... NP_001 EMERPGEGEKELAEKEEWKKRDGEEQEQKEREQGHQKERNQEMEEGGEEEHGEGEEEEGD 690 700 710 720 730 740 100 110 120 130 140 150 pF1KE4 FEDELSEVLENQSSQAELKEAVEEPSSKDVME-KREDSKEAEKSGE--ATDGARPQALPE :.: : :..... : :: :. : :.:. :..:: . .: . : NP_001 REEE--EEKEGEGKEEGEGEEVEGEREKEEGERKKEERAGKEEKGEEEGDQGEGEEEETE 750 760 770 780 790 800 160 170 180 190 200 pF1KE4 PMQESKAEGNN-------QAPGEEEEEEEEATNTHPPASLPSQKYPGPQAEGDSEGLSQG : : ::.. .. ::.::::::. . . . .. : . ::...: .: NP_001 GRGEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEEEG 810 820 830 840 850 860 210 220 230 240 250 260 pF1KE4 LVDREKGLSAEPGWQAKREEEEEEEEEA--EAGEEAVPEEEGPTVVLNPHPSLGYKEIRK :.: . : : ... : :::: : : :: :::: . . . : : .. NP_001 ----EEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGE--GEEEGEGEGEEEE 870 880 890 900 910 270 280 290 300 310 320 pF1KE4 GESRSEALAVDGAGK----PGAEEAQDPEGKGEQEHSQQKEEEEEMAVVPQGLFRGGKSG ::...: . .: :. : :..: ::.::.:... . :::: : .: . : NP_001 GEGKGEEEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEE------GEGEGEEEG 920 930 940 950 960 970 330 340 350 360 370 380 pF1KE4 ELEQEEERLSKEWEDSKRWSKMDQLAKELTAEKRLEGQEEEEDNRDSSMKLSFRARAYGF : : :: . : :... .. .. .: .:.. ::.:: : . . . .... : NP_001 EGEGEEGEGEGEEEEGEGEGEEEEGEEE--GEEEGEGEEEGEGEGEEEEEGEVEGEVEGE 980 990 1000 1010 1020 390 400 410 420 430 pF1KE4 RGPGP-QLRRGWRPSSREDSLEAGLPLQVRGYPEEKKEEEGS-------ANRRPEDQELE .: : . ..: . . :. . : . : ::..::::. :.: . .: . NP_001 EGEGEGEEEEGEEEG--EEREKEGEGEENRRNREEEEEEEGKYQETGEEENERQDGEEYK 1030 1040 1050 1060 1070 1080 440 450 pF1KE4 SLSAIEAELEKVAHQLQALRRG ..: :.. .. :. NP_001 KVSKIKGSVKYGKHKTYQKKSVTNTQGNGKEQRSKMPVQSKRLLKNGPSGSKKFWNNVLP 1090 1100 1110 1120 1130 1140 457 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 00:37:53 2016 done: Sun Nov 6 00:37:55 2016 Total Scan time: 12.370 Total Display time: 0.000 Function used was FASTA [36.3.4 Apr, 2011]